#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 19, 2025; 0:31 GMT TreeBASE (cc) 1994-2008 Study reference: Anderson F., Cordoba A., & Thollesson M. 2004. Bilaterian phylogeny based on analyses of a region of the sodium-potassium ATPase alpha subunit gene. Journal of Molecular Evolution, 58(3): 252-268. TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S1013] BEGIN TAXA; TITLE Amino_Acid_ML_Quartet_Puzzling; DIMENSIONS NTAX=52; TAXLABELS Acrosternum_hilare Anguilla_anguilla Artemia_franciscana Asterina_miniata Bufo_marinus Caenorhabditis_elegans Callinectes_sapidus Canis_familiaris Caprella_sp. Carcinus_maenas Catostomus_commersoni Conopeum_sp. Ctenocephalides_felis Danio_rerio Doru_lineare Drosophila_melanogaster Dugesia_japonica Gallus_gallus Garypus_californica Harmonia_axyridis Homo_sapiens Hubrechtella_dubia Hydra_vulgaris Lampsilis_cardium Lepidochitona_hartwegi Lineus_ruber Lottia_austrodigitalis Loxoceles_reclusa Macoma_nasuta Octopus_rubescens Onchidella_borealis Oreochromis_mossambicus Ovis_aries Pantinonemertes_sp._nov. Phoronopsis_viridis Rattus_norvegicus Schistosoma_mansoni Scolopocryptops_sexspinosa Strongylocentrotus_purpuratus Sus_scrofa Tegula_brunnea Tenebrio_molitor Terebratalia_transversa Torpedo_californica Watersipora_subtorquata Xenopus_laevis brachyceran_dipteran diplopodan_1 diplopodan_2 nematoceran_dipteran oniscidean_isopod opilionid ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M587] TITLE ATPaseReducedAminoAcid; LINK TAXA = Amino_Acid_ML_Quartet_Puzzling; DIMENSIONS NCHAR=981; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y *" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 ] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] Acrosternum_hilare ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDNQIIEADTTEDQSSPGFKALARIATLCNRAEFKGGQEGVPILKKEVNGDASEAALLKCMELALGDVMSIRRRNRKVCEIPFNSTNKYQVSIHMVMKGAPERILDRCSTIFIGGKEKLLDEEMKEAFNNAYLELGGLGERVLGFCDLMLPSDKFPLGFKFDCDEP-NFPLNGMRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGEHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSE---VNPREAKAAVVHGTELRDTGPDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILLDIPLPLGTVTILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Anguilla_anguilla DMDDLKKEVDLDDHKLTLDELHRKYGTDLTRGLTSSRAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQAASE-DEPANDNLYLGVVLSAVVIITGCFSYYQEAKSSRIMDSFKNLVPQQALVIRDGEKKCINAEEVVAGDLVEVKGGDRIPADLRVASAQGCKVDNSSLTGESEPQTRSPDFSNENPLETRNIAFFSTNCVEGTARGVVINTGDRTVMGRIATLASSLEVGRTPISIEIEHFIHIITGVAVFLGVSFFILSLILGYAWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSSATWAALARIAGLCNRAVFLAEQSNVPILKRDVAGDASESALLKCIELCCGSVNDMRDKHVKIAEIPFNSTNKYQLSIHLVMKGAPERILDRCSTIMIHGKEQPLDDEMKDAFQNAYVELGGLGERVLGFCHYFLPDDQFAEGFQFDTEEV-NFPTENLCFIGLMSMIDPPRAAVLDAVGKCRSPGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPINE---VNPRDAKACVVHGGELKDLTPEQLDDILKHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISIAYGQIGMMQATAGFFTYFVILAENGFLPSTLLGIRVKWDDKYVNDLEDSYGQQWTYEQRKIVEYTCHTSFFASIVIVQWADLIICKTRRNSIIQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSLLIFLYDEARRFILRRNPDG-WVERETYY Artemia_franciscana DLNELKKELDIDFHKIPIEECYQRLGSNPETGLTNAQARSNIERDGPNCLTPPKTTPEWIKFCKNLFGGFALLLWTGAILCFLAYGIEASSGNEDMLKDNLYLGIVLATVVIVTGIFSYYQENKSSRIMDSFKNLVPQYALALREGQRVTLKAEELTMGDIVEVKFGDRVPADLRVLEARSFKVDNSSLTGESEPQARSPEFTNDNPLETKNLAFFSTNAVEGTMRGIVIGIGDNTVMGRIAGLASGLDTGETPIAKEIAHFIHIITGVAVFLGVTFFIIAFVLGYHWLDAVVFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDGTITEADTTEDQSSAGWKALVKIAALCSRAEFKPNQSTTPILKREVTGDASEAAILKCVELTTGETEAIRKRNKKICEIPFNSANKFQVSIHLVMKGAPERILERCSTIFMNGKEIDMTEELKEAFNNAYMELGGLGERVLGFCDYLLPLDKYPHGFAFNADDA-NFPLTGLRFAGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAARLNIPVSE---VNPRDAKAAVVHGGELRDITPDALDEILRHHPEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIVYTLTSNIPEISPFLLFILFDIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRRPRNPVTDKLVNERLISLAYGQIGMIQASAGFFVYFVIMAECGFLPWDLFGLRKHWDSRAVNDLTDSYGQEWTYDARKQLESSCHTAYFVSIVIVQWADLIISKTRRNSVFQQGMRNNILNFALVFETCLAAFLSYTPGMDKGLRMYPLKINWWFPALPFSFLIFVYDEARKFILRRNPGG-WVEQETYY Asterina_miniata ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDNTIVEADTTEDQSTPSWKALARIACLCNRSEFKAGQESVPILNRETTGDASESALVKCVELAMGSVLDFRSKNKKLAEIPFNSTNKYQVSVHLVMKGAPERILDRCSTILMKG{LQ}EEPMGDDMKVAFNNAYLELGGLGERVLGFCQYFLPEKEFPQGFEFDAEDV-NFPLEGLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAERLGIDASE---VNKADAKAVVVHGSELRDITNEELDDILVNHTEIVFARTSPQQKLIIVEGCQRGGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLFFILAQVPLPLGTVTILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Bufo_marinus DMEELKKEVTMEDHKMTLEELHRKYGTDLTRGLTTARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIRKASD-LEPDNDNLYLGVVLSAVVIITGCFSYYQEAKSSRIMESFKNMVPQQALVIRNGEKLSINAENVVQGDLVEVKGGDRIPADLRIISAHGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEGGQTPIAVEIGHFIHIITGVAVFLGVSFFILSLILHYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSSPTWTALARIAGLCNRAVFPAGQENTPILKRDVVGDASESALLKCIELCCGSVKDMREKNQKVAEIPFNSTNKYQLSVHLVMKGAPERILDRCSSILLQGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLLLDDEQFPDGFSFDTEDV-NFPTEGLCFVGLISMIDPPRAAVPDRVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVNQ---VNPRDAKACVIHGTDLKDMNADQIDDILRHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGIAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIADIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRHARNPKKDKLVNERLISMAYGQIGMIQALGGFFAYFVILAENGFLPSTLLGIRVAWEDRYVNDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPTWWFCAFPYSLLIFIYDEVRKLILRRSPGG-WVEKETYY Caenorhabditis_elegans ELHDLKQEVKMDEHIVPIEELVARLGTNLETGLTRQKAQEVLAKNGPNALSPPETTPEWIKFCKNLFGGFAMLLWVGAILCYIAYSVDYFTM-EYPSKDNLYLGIVLMTVVVITGVFQYYQESKSSKIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNSSLTGESEPQSRSPDCTNENPLETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIAREIEHFIHLITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWYDETIHECDTTETQTGASFEALVRIASLCNRAEFKAGQQDTPILRRDCTGDASEIALLKFTELTQGNVIAVREKNKKIAEIPFNSTNKYQVSIHLVMKGAPERILDVCSTIFLNGKESELTDKLREDFNTAYLELGGMGERVLGFCDFVLPADKFPKGFKFDVEEV-NFPLKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVVMVTGDHPITAKAIAKSVGIISDGTETVEDIAIRRGIPVEE---VNPREAKAAVIHGSDLREMSEDQLAEIIKYHSEIVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLTYILFGIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPRDPIRDKLVNERLISLAYGQIGMIQASAGFFTYFWIMADNGFMPWDLYQLRAQWDSRAYNNVLDSYGQEWTYANRKILEYTCQTAYFVSIVVVQWADLIISKTRRNSLVQQGMSNWTLNFGLVFETALAWFMCYCPGLDNGLRMYGLRFSWWFCALPFSILIFVYDEIRRFLIRRYPGG-WVERETYY Callinectes_sapidus DMDNLKQELELDEHKVPIEELFQRLSVNPDTGLTQAEARRRLERDGPNALTPPKQTPEWVKFCKNLFGGFSLLLWIGAILCFIAYSIEAASE-EEPNNDNLYLGIVLTAVVIITGIFSYYQESKSSRIMESFKNLVPQYAIVIREGEKLNVQAEELCIGDIIDVKFGDRIPADMRVIEARGFKVDNSSLTGESEPQSRSPEFTSENPLETKNLAFFSTNAVEGTCKGIVINIGDNTVMGRIAGLASGLETGETPIAKEISHFIHIITGVAVFLGVTFFVIAFIMGYHWLDAVVFLIGIIVANVPEGLLATVTVCLTLTAKRMAAKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNTIIEADTSEDQSSDGWKALSRIAALCNRAEFKTGQEDVPILKREVNGDASEAALLKCVELAIGDVRGWRSRNKKVCEIPFNSTNKYQVSIHLVMKGAPERILERCSTIFMNGEEKPLDEEMKESFNNAYLELGGLGERVLGFCDYVLPSDKYPLGYPFDADAV-NFPVHGLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPIKE---VDPREAKAAVVHGSELRDMTSEQLDDVLIHHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLFFMIASVPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPRNPFTDKLVNERLISMAYGQIGMIQALAGFYVYFVIMAENGFLPPVLFGIREQWDSKAINDLEDYYGQEWTYHDRKILEYTCHTAFFVAIVVVQWADLIICKTRRNSILHQGMKNMVLNFGLCFETTLAAFLSYTPGMDKGLRMYPLKFYWWLPPLPFSLLIFVYDECRRFVLRRNPGG-WVEMETYY Canis_familiaris DMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTTARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQAATE-EEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVIGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVKGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRDRYAKIVEIPFNSTNKYQLSIHLVMKGAPERILDRCSSILLHGKEQPLDEELKDALQNAYLELGGLGERVLGFRHLFLPDEQFPEGFQFDTDDV-NFPVENLCFVGFISMIGPPRAAVPDAVGKCRGAGIKVIMVTGDHPITAKAIAKGAGIISEGNETVEDIAARLNIPVRQ---VNPRDAKACVVHGSDLKDMTSEQLDGILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIVGSDASKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPTHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGG-WVEKETYY Caprella_sp. -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------?IEADTSEDQSSDGWKALSTIAALCNRAEFRSGQDGVSILKREVNGDASEAALLKCCELACGDVMGWRKKNKKICEIPFNSTNKYQVSIHLVMKGAPERILERCSTIFINGEDKPLDEELKESFNNAYLELGGLGERVLGFCDYRLPADKYPVGFPFDSDNC-NFPVHSLRFVGLISLIDPPRAAVPDAVNKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVDDIANRLNIPIKE---VDPRQAKAAVVHGIELRDMTSDQLDDILRHHTEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLFFMVGSVPLPLGTVTILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Carcinus_maenas ----------------------------------------------------------------------SLLLWIGAILCFIAYSIEAASE-EEPNNDNLYLGIVLTAVVIITGIFSYYQESKSSRIMESFKNLVPQYAIVIREGEKLNVQAEELCIGDILDVKFGDRIPADMRVIEARGFKVDNSSLTGESEPQSRSSEFTSENPLETKNLAFFSTNAVEGTCKGIVINIGDQTVMGRIAGLASGLETGETPIAKEISHFIHIITGVAVFLGVTFFVIAFIMGYHWLDAVVFLIGIIVANVPEGLLATVTVCLTLTAKRMAAKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNTIIEADTSEDQSSEGWKALSRIAALCNRAEFKTAQDDVPILKREVNGDASEAALLKCVELAIGDVRGWRTKNKKVCEIPFNSTNKYQVSIHLVMKGAPERILERCSTIFMNGEEKPLDEEMKESFNNAYLELGGLGERVLGFCDYTLPTDKYPLGYPFDADSV-NFPVHGLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPIKE---VDPREAKAAVVHGSELRDMTSEQLDDVLIHHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLFFMIASVPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRQPRNPFTDKLVNERLISMAYGQIGMIQALAGFYVYFVIMAENGFLPPTLFGIREQWDSKAINDLTDYYGQEWTYHDRKVLEYTCHTSFFVAIVVVQW--------------------------------------------------------------------------------------------- Catostomus_commersoni DMDELKKEVDLDDHKLSLEELHHKYGTDLSKGLSNSRAEEILARDGPNALTPPPTTPEWVKFCKQMFGGFSMLLWTGAVLCFLAYGILAAME-DEPANDNLYLGVVLSAVVIITGCFSYYQDAKSSKIMDSFKNLVPQQALVVRDGEKKQINAEEVVIGDLVEVKGGDRIPADLRIISSHGCKVDNSSLTGESEPQTRSPDFSNDNPLETKNIAFFSTNCVEGTARGIVISTGDRTVMGRIATLASGLEVGRTPISIEIEHFIHIITGVAVFLGVSFLLLSLVLGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSSDTWASLARIAGLCNRAVFLAEQIDVPILKRDVAGDASESALLKCIELCCGSVKEMREKFTKVAEIPFNSTNKYQLSVHLVMKGAPERILDRCATIMIQGKEQLLDDEIKESFQNAYLELGGLGERVLGFCHFYLPDEQFPEGFQFDADDV-NFPTENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVNE---VNPRDAKACVVHGGDLKDLSCEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRTGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLFFIIANIPLPLGTVTILCIDLGTDMLPAISLAYEAAESDIMKRQPRNPKTDKLVNERLISIAYGQIGMIQALAGFFTYFVILAENGFLPPRLLGIRMNWDDKYINDLEDSYGQQWTYEQRKIVEFTCHTAFFTSIVIVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPNWWFCAFPYSLLIFIYDEIRKLILRRNPGG-WMERETYY Conopeum_sp. ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDNVIYEADTSDDQTNPSWLNLARCAMLCNRAEFKVGQEEVPVLKRECNGDASESALLKCVELSMGNVTQYRNRNKKIAEIPFNSTNKYQVSIHLVMKGAPERILDRCSTIFMKGEELPMDENWKESFEKAYLELGGLGERVLGFCDYVLPGDQFPPGFPFDADEE-NFPLTGLRFLGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKGVGIISPKNRTVEDLAEERGVPVSE---VPPRDAKAAVVHGGDLRDMTAEDIDNILRYHTEIVFARTSPQQKLIIVEGCQRAGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVE{E*}GRLIFDNLKKSIAYTLTSNIPEISPFLFFILFDVPLPLGTITILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ctenocephalides_felis ELDDLKQELDIDFHKVSPEELYQRFNTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFALLLWIGAILCFVAYSIQASTV-EEPADDNLYLGIVLAAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVLREGEKLTLRAEDLVLGDVVEVKFGSRIPADIRIIESRGFKVDKSSLTGESEPQSRGPEFTNEKPLETKNLAFFSINAVEGTAKGVVISCGDNTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAIILNYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSSPGFKALARIATLCNRAEFKGGQEGVPILKKEVSGDASEAALLKCMELALGDVMSIRKRNKKVCEIPFNSTNKYQVSIHMVMKGAPERILEKCSTIFIGGKEKLLDEEMKEAFNNAYLELGGLGERVLGFCDLMLPTDKFPLGFKFDSDDP-NFPIENLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSE---VNPREAKAAVVHGTELRELNSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDPVNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPMKLFGIRKQWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFVSIVVVQWADLIVCKTRRNSLLHQGMRNWALNFGLVFETALAAFLSYTPGMDKGLRMFPLKFVWWLPALPFMISIFIYDETRRFYLRRNPGG-WLEQETYY Danio_rerio DMDELKKEVDLDDHKLSLDELTRKYNTDLTRGLSGTRAKEILARDGPNALTPPPTTPEWVKFCKQLFGGFSTLLWIGAILCFLAYGILAASE-EEPANDNLYLGIVLSAVVMITGCFSYYQEAKSSKIMDSFKNLVPQQALVIRDGEKKNINAEEVAVGDLVEVKGGDRIPADLRIISAHGCKVDNSSLTGESEPQTRTPDFSNDNPLETRNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEVGRTPISIEIEHFIHIITGVAVFLGVSFFILSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSSATWAALARVAGLCNRAVFLAEQENIPILKRDVAGDASESALLKCIELCCGSVKEMREKYNKISEIPFNSTNKYQLSIHLVMKGAPERILDRCSSILIQGKEQPLDDEMKDAFQNAYLELGGLGERVLGFCHFNLPDEQFPEDFQFDTEEV-NFPTENLCFIGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPINE---VNPRDAKACVIHGGDLKDLSPEQLDDVLKHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPKTDKLVNERLISIAYGQIGMIQALAGFFTYFVILAENGFLPSSLLGIRVFWDDKYVNDLEDSYGQQWTYEQRKIVEFTCHTAFFTSIVIVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPNWWFCAFPYSLLIFIYDEIRKLIIRRSPGG-WVERETYY Doru_lineare ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDNQIIEADTTEDQSSPGFKALATIATLCNRAEFKSGQENVPILKKEVNGDASEAALLKCMELALGDVMSIRKRNKKVCEIPFNSTNKFQVSIHLVMKGAPERILDKCSTIFIGGKEKVLDEEMKEAFNNAYLELGGLGERVLGFCDFMLPSDKFPLGFKFDCDDP-NFPIIGLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSE---VNPREAKAAVVHGTELRDLGSEQIDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCI?--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Drosophila_melanogaster NLDDLKQELDIDFHKISPEEMYQRFQTHPENGLSHARAKENLERDGPN-LTPPKQTPEWVKFCEDLFGV-AMLLWIGAILCFVAYSIQASTS-EEPADDNLYLGIVLSAVVIVTGVFSYYQESKSSKIMESFKNMVPQFATVIREGEKPSLRAEDLVLGVLVELEFGDLIPLVYRIIEARDFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEALPKGVVISCGDHTVMGRIAALASGLDTG-TPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSGDASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHLVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDI-NFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSE---VNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLASILCDIPLPLGTVTILCIDLGTDMVPAISLAYDHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQEWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLSYCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGG-WLEQETYY Dugesia_japonica DLDNLKKELDIDSHRIPIKDLYIRLQSDPDKGISYEDAKMRLARDGPNALTPPKTTPEWVKFCKQLFGGFSLLLWIGAVLCFLAYAIQSGAY-EDPPKDNLYLGVVLTAVVVITGCFSYYQDAKSSKIMESFGKMVPQKANVIREGKISEISAENLVVGDVIEVKFGDRVPADIRVIQASSFKVDNSALTGESEAQVRTPEFTNDNPLETKNIAFFSTNAVEGTCRGIVISVGDNTVMGRIANLASGLEMGMTPIAKEINHFIHIITGVAVFLGVSFFVIAFILGYFWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNKIQESDTSENQISDTWKMLARISMLCNRAQFKAGEEDKPVLKRDCTGDASESALLKCVELSIGGVTKYREENKKIVEIPFNSTNKYQVSIHIAMKGAPERILERCSTILIDGKEVHMDDHWKQEFNNAYLELGGMGERVLGFCDFRLDENEFPKGFKFNPDEV-NFPLDGLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNRTVDDIAAERGISPSE---VNPRDARACVIHGSDLRDMTSEQLDEVLKHHDEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRIIFDNLKKSIAYTLTSNIPEITPFLVFILADVPLPLGTITILCIDLGTDMVPAISLAYEEAESDIMKRKPRDPKHDKLVNERLISMAYGQIGMIQASGGFFVYFVIMAEQGFWPSRLLGLRKEWDSAAVNDLADSYGQEWTFEQRKKLEYTCHTAFFVSIVIVQWTDLMICKTRRNSIFQQGMWNHQMTFGLFFETTLAAFLTYCPGLDVALKMQPLRFTWWLPAIPFSASIFIYDEVRKYLLRKWKNGSWLENETYY Gallus_gallus DMDELKKEISMDDHKLSLDELHRKYGTDLSRGLTTARAAEILARDGPNTLTPPPTTPEWVKFCRQLFGGFSLLLWIGSLLCFLAYGITSVME-GEPNSDNLYLGVVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVVRNGEKMSINAEGVVVGDLVEVKGGDRIPADLRIISAHGCKVDNSSLTGESEPQTRSPDFSNENPLETRNIAFFSTNCVEGTAVGIVISTGDRTVMGRIASLASGLEGGKTPIAMEIEHFIHLITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVGTLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSSATWLALSRIAGLCNRAVFQANQENVPILKRAVAGDASESALLKCIELCCGSVKEMRERYPKVVEIPFNSTNKYQLSIHLVMKGAPERILDRCDSILIHGKVQPLDEEIKDAFQNAYLELGGLGERVLGFCHLALPDDQFPEGFQFDTDEV-NFPVEKLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISDGNETVEDIAARLNIPVSQ---VNPRDAKACVVHGSDLKDMTSEQLDDILLHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTCTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVIMAENGFLPSGLVGIRLQWDDRWINDVEDSYGQQWTFEQRKIVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPTWWFCAFPYSLLIFLYDEIRKLIIRRNPGG-WVERETYY Garypus_californica -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IIEADTTEDQSSTGWKALSRSCCLCSRADFKAGQENVPILKRECAGDASESAILKCMELAVGNVTQFRRNNPKVCEIPFNSTNKYHVTIHLCMKGAPERILDRCSTIYIGGEEKELDEEMKESFNNAYLELGGLGERVIGFCDKKLPLDKYPNGYPFDADEQ-NFPISNLRFIGLVSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKAVGIISEGNETVEDIAQRLNIPVEE---VNPRDAKAAVVHGSELRDFSSYQLDDILKNHTEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGV{E*}EGRLIFDNLKKSIAYTLTSNIPEI{INST}PFLIFI?------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Harmonia_axyridis ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDNQIIEADTTEDQSSPGFKALSRIATLCNRAEFKPGQDNVPILKREVNGDASEAALLKCMELALGDVMSIRRKNKKVCEVPFNSTNKYQVSVHMVMKGAPERILERCSTIFICGKEKVLDEEMKEAFNNAYLELGGLGERVLGFCDYLLPSDKFPLGFKFNSDDP-NFPIDGLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSE---VNPREAKAAVIHGSDLKDLSSEQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Homo_sapiens DMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATE-EEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDV-NFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQ---VNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGG-WVEKETYY Hubrechtella_dubia ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------?DNRVVEADTSDDQSCDTWMNLARIAMLCNRAEFKVGQDEVPVLKRECNGDASESALLKCVELSIGHVSEFRARNPKVTEIPFNSTNKYQVSIHLVMKGAPERILDRCSTILINGHELELDEKWKDAFNSAYLELGGLGERVLGFCDYHLPTEQFPPGYPFDPDEE-NFPLSGLRFVGLMAMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIATRLNIPVSE---VNPRDAKACVVHGSDLRDMTPAQIDELLDEHSEIVFARTSPQQKLIIVEGCQRQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLLFILVDVPLPL{AG}T{FI}TILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Hydra_vulgaris KLEDLKKELEMTEHSMKLESLLSMYETSLEKGLSENIVARNLERDGLNALTPPKQTPEWVKFCKQMFGGFSMLLWIGAILCFFAFGIRAVRD-TNPNMDELYLGIVLSVVVIITGCFSYYQESKSSKIMESFKKMIPQEALVLRDGKKITINAEQCVVGDVVFVKFGDRIPADIRIVECKGLKVDNSSLTGESEPQSRAVDFTHENPIETKNLAFFSTNAVEGTATGIVVRIGDNTVMGRIANLASGLGSGKTPIALEIEHFIHIVTGVAVFLGVSFLIISLAMGYHWLEAIIFLIGIIVANVPEGLLATVTVCLTLTAKKMAKKNCLVKHLEAVETLGSTSVICSDKTGTLTQNRMTVAHMWFDKMIVEADTTEDQSSLTWKSLAKVAALCSRAEFKPNQNDVAVLRKECTGDASETAILKFVELSVGNVMDIRAKNKKVTEIPFNSTNKYQVSVHLVMKGAPEKVLERCSTILINGEEQPLKDDVIEIYNKAYDELGGLGERVLGFCHYYLPVDQYPKGFLFKTEEEQNFPLEGLCFLGLLSMIDPPRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNECEEDIALRLNIPLEDLSEDQKKSAKACVIHGAKLKDIKNEELDKILCDHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIVYTLTSNIPEISPFLMFILFGIPLPLGTITILCIDLGTDMVPAISLAYEKAESDIMKRHPRNPIRDKLVNERLISLAYGQIGMMQATAGFFTYFIILAENGFLPSYLFGLRSQWDDMSNNNLLDSFGSEWTYFQRKEIELTCQTAFFTTIVVVQWADLIISKTRRLSLFQQGMTNWFLNFGLFFETALAAFLQYTPGVNTGLRLRPMNFTWWLPGLPFSLLIFVYDEIRRYLLRKNPGG-WVEKETYY Lampsilis_cardium ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------?DGRIVEADTSDDQSDPTWIALARISMLCNRAEFKTGQEDVPVLKRECNGDASESALLKCVELSIGNVTSFRQRNKKISEIPFNSSNKYQVSIHLVMKGAPERILDRCSSY{IM}RDGKEYAVDEPFRMAFNSAYLELGGLGERVLGFCDYFLPTDQFPPGYEFDPDEE-NFPLTGLRFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGSMTVEDIAAERGIPPEE---VDPREAKAAVLHGSDLRDMTPAQIDEFLRNHSEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILFDMPLPLGTITILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Lepidochitona_hartwegi ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDGKIVEADTSDDQSNANWIALSRVSMLCNRAEFKVGQEDVPVLKRDCNGDASESALLKCVELSLGNVSEFRRRNRKVVEIPFNSTNKYQVSVHLVMKGAPERILDRCGTILMGGKEYPMDDNFKESFNSAYLELGGLGERVLGFCDYFLPSENFPPGFPFDADEE-NFPLENLRFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGSKTVEDIAEDRGVPVGE---VDPRDAKAAVIHGSDLRDMTPATIDEVLRDHAEIVFARTSPQQKLIIVEGCQRQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLLFIVLDIPLPLGTITILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Lineus_ruber ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------?DNRIV{EKQ*}ADTSDDQSDSTWLALA{HR}VGMLCNRAEFKTGQEDVPVLKRECNGDASESALLKCVELSMGKVIEYRIKNKKVCEIPFNSTNKYQVSIHLVMKGAPERILDRCSVIMNNGREEPMDEKWRASFESAYLELGGLGERVLGFCDFPLDPNQFPIDYPFDSEDP-NFPLTGLRFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNDTVEDIASRLNIPVTE---VNPRDALACVVHGSDLRDMTPAQIDEILKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLLFIIANIPLPLGTITILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Lottia_austrodigitalis ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDGHILEADTTDDQSDPTWNALARIAMLCNRAEFKTAQENVPILKKECNGDASESALLKCVELSIGNVTEYRRKNNKICEIPFNSTNKYQLSIHLVMKGAPERIMDRCSTVLLNGKETPLDDNFREAFNAAYLELGGLGERVLGFCDYMLPNEQYPPGYEFDPEGP-NFPVTGLRFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGSKTVEDVASERGIPVEE---VDPRDAKAAVVHGQDLRDMTPAQIDEILRNHNEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIP?---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Loxoceles_reclusa --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------?EADTTEDQ{ST}S{PS}GW{KQ}ALS{RW}VA{LMRW}LCSRAEFKPGQ{DE}{FIKLMNY*}{CFIS}{HP}ILKR{DE}CTGDASESAILKCMELAVG{DN}VA{APST}FR{AGPR}NN{AGPR}KVCEIPFNSTNKYHVTIHLCMKGAPER{IV}L{DE}RCSTIFINGK{DE}K{IMV}{FL}DEEMK{DE}AFNNAYLE{FL}GG{FL}GERVIGFCD{FHLQY*}{HIKLMNPQRST}{LMV}PP{DE}KYPHGYPFD{PS}DEQ-NFPL{DE}{ACDFGHILNPRSTVY}LRF{FLV}G{FILMV}{IV}{APST}MIDPP{GR*}AA{DEV}PDAVAKCRSAGIK{ADEGV}?MV{ST}GDHPITAAAIAKSVGIISEGNETVEDIALRLDIPIEE---VNPNDAKAAVIHGGQLREMTSEELDDVLKHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLVFILADIPLPLGTVTILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Macoma_nasuta ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDGKIVEADTSDDQSDASWLALSRCSMLCNRAEFKVDQEDVPVLKRECNGDASESALLKCVELSIGHVIEFRKRNNKICEIPFNSSNKYQVSIHLVMKGAPERILDRCSIYLKDGKEHPLDDPFRVAFNTAYMELGGLGERVLGFCDYILPIDQYPPGYQYDADDA-NFPLTGLRFIGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGSRTVEDIAMERGIPPEE---VDATEAKAAVVHGGDLRDMTPFQIDEILMNHSEIVFARTSPQQKLIIVEGCQRQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLFFIVLDIPLPLGTITILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Octopus_rubescens ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGKIVEADTSEDQSNDDWKALSRIAMLCNRAEFKAGQDGVPVLKKECNGDASESALLKCVELSIGGVAEYRRRNKKVVEIPFNSTNKYQVSIHLVMKGAPERIMERCTIALVNGKEMTIDESFKNDFNTAYMELGGLGERVLGFCDYTLPTESFPPGFQFDGDEV-NFPLNGLRFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGSKTVEDLAAEQGVTVDQ---VNPRDAKAAVIHGSDLRDMTPAQIDEILRNHSEIVFARTSPQQKLIIVEGCQRQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLFFILLDIPLPLGTITILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Onchidella_borealis --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERIMDRCSTILMHGKDQPLDDNFREAFNSAYLELGGLGERVLGFCDYYLPSDEFPPGFDFDPDGP-NFPLTGLRFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIICEGSKTVEDISAERSIPVEE---VDPREAKAAVIHGGDLRDMTPAQIDEILVNHAEIVFARTSPQQKLIIVEGCQRQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLIFIIADIPLPLGTIT?------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Oreochromis_mossambicus DMDDLKKEVDLDDHKLTLDELHRKYGTDLTRGLSSSRAKEILARDGPNALTPPPTTPEWVKFCKQLFGGFSMLLWIGAILCFLAYGIQAASE-DEPANDNLYLGIVLSAVVIITGCFSYYQEAKSSKIMESFKNLVPRQALGIRDGEKKNINAEEVVLGDLVEVKGGDRIPADLRIISAHGCKVDNSSLTGESEPQTRSPDFSNENPLETRNISFFSTNCIEGTARGIVINTEDRTVMGRIATLASSLEGGKTPIAIEIEHFIHIITGVAVFLGVSFFILSLILGYNWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSSATWANLSRIAGLCNRAVFLADQSNIPILKRDVAGDASEAALLKCIELCCGSVNEMREKYPKIAEIPFNSTNKYQLSIHLVMKGAPERILDRCNSIVLQGKVQALDDEMKDAFQNAYVELGGLGERVLGFCHYHLPDDEFPEGFAFDTDEV-NFPTENLCFVGLMAMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNVPVSE---VNPRDAKACVVHGSELKDMTSEELDDLLKHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPKTDKLVNERLISIAYGQIGMMQATAGFFTYFVILAENGFLPMDLIGVRVLWDDKYVNDLEDSYGQQWTYERRKIVEYSCHTAFFASIVIVQWADLIICKTRRNSIVQQGMTNRILIFGLFEETALAAFLSYCPGMDVALRMYPMKPLWWFCAFPYSLLIFLYDEARRYILRRNPGG-WVEKETYY Ovis_aries DMDELKKEVSMDDHKLSLDELHRKYGTDLNRGLTTARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAVLCFLAYGIQAATE-EEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSSATWLALSRIAGLCNRAVFQANQDNLPILKRAVAGDASESALLKCIEVCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHLVMKGAPERILDRCSSILIHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLMLPDEQFPEGFQFDTDDV-NFPVDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQ---VNPRDARACVVHGSDLKDMTPEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPQTDKLVNERLISMAYGQIGMIQALGGFFTYFVIMAENGFLPNHLLGIRVTWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGG-WVEKETYY Pantinonemertes_sp._nov. ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------?DNKIVEAETSDDQSSSSWIALADVAMLCNRAEFKVGQEEVPVLKRECNGDASESALLKCVELSFGNVTAYRASRKKVCEIPFNSTNKYQVSIH{LM}VMKGAPERILDRCGKILINGQELTLDEKWKAAFNSAYLELGGLGERVLGFCDLILPPENFPPGYPFDG{DE}GP-NFPLENLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAATRGIPVSE---VNPRDAKACVVHGSDLRDMTPAQIDEVLRNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFD{KN}LKKSIAYTLTSNIPEISPFLFFILLDIPLPLGTITILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Phoronopsis_viridis ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NETWLSLARISMLCNRAEFKIGQEEVPVLKRECNGDASESALLKCVELSIGNVTAFREANKKLVEIPFNSSNKYQVSVHLVMKGAPERILDRCSTILMAGQERKLDDEMKRAFNDAYMELGGLGERVLGFCDYFLPTEQFPPNFQFDADDV-NFPLEGLRFVGLMAMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNECVEDIAARLGIPVED---VNPRDAHACVVHGSDLRDMTPAQIDDILQNHTEIVFARTSPQQKLIIVEGCQRQGSIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLVFILADVPLPLGVITILCID?-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Rattus_norvegicus DMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTPARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIRSATE-EEPPNDDLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEDVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAEEIEHFIHLITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSSATWFALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIEVCCGSVMEMREKYTKIVEIPFNSTNKYQLSIHLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLLLPDEQFPEGFQFDTDEV-NFPVDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVNQ---VNPRDAKACVVHGSDLKDMTSEELDDILRYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIVGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPFHLLGIRETWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGAALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGG-WVEKETYY Schistosoma_mansoni DLNELKQELDMDEHRISLDELYSRLSTDPQSGLTAEQAKTRLERDGPNALTPPKTTPEWVKFCKTLFGGFSLLLWIGAVLCFIAFSIESGTH-EDPPKDNLYLGIVLSVVVVVTGCFSYYQESKSSRIMESFKKMIPQTALVIRGGVKIEAPAEALVVGDLIDVKCGDRVPADIRIISASSFKVDNSALTGESEPQSRTSEYTNENPLETKNLAFFSTNAVDGTCRGIVVSTGDRTVMGRIANLASGLQIGQTPINKEINHFIHLITSVAVFLGVSFFVIAFILGYHWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTIAHMWFDNKIFDADTTDDQSSPTWIALARIGMLCNRAEFKVGEENKPVLKRECNGDASESALLKCVELSFGGVTEYRRKNPKVAEIPFNSTNKYQLSIHLVMKGAPERILDRCGTILINGKEEVMDESMRENFNSAYLELGGMGERVLGFCDYRLPLDTYKKGYPFNVDEP-NFPLTNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKGVGIISESSKTVEDIAAERGIPVSQ---VNPRDAQACVIHGSDLREMTPAQIDDILLNHSEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKQADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRIIFDNLKKSIAYTLTSNIPEITPFLVYILADIPLPLGTITILCIDLGTDMIPAISLAYEEAEADIMKRMPRDPLHDKLVNERLISMAYGQIGMIQASGGFFVYFVIMAENGFWPSRLLGIRREWDSKAINDLADSYGQEWTYNQRKRLEYTCHTAFFASIVIVQWTDLMICKTRRNSIFQQGMWNHHLTFGLFFETTLAIFLSYCPGLDKGLRMMPMRFTWWLPGLPFSFLIFVYDEVRKFLLRRLPPGSWLEKETYY Scolopocryptops_sexspinosa ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDNQIIEADTTEDQSSPGFQALSRIAILCNRAEFKGNQDNVPILKRETTGDASESALLKCMELAIGNILTFRNANKKICEIPFNSTNKYQVSVHLMMKGAPERILERSSTITINGKDSPLDEEMKEAFNNAYLELGGLGERVLGFCDLKLPADKFPPGYPFDADEE-NFPLNGMRFVGLMSMIDPPRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAARLNIPVEE---VDPREAKAAVIHGSELREMTGDQLDDILRHHTEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLIFILGDVPLPLGTVTILCI?--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Strongylocentrotus_purpuratus ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDNTIVEADTTEDQSSPTWMALARIACLCNRSEFKAGQENVPILKRDTTGDASESALVKCVELCMFNVTEYRKKNKKVCEIPFNSTNKYQVSIHLVMKGAPERILDRCTTILIKGKEIDMNEEMQTAFNNAYLELGGLGERVLGFCQCYLPADQFPLGF{AG}FDADDV-NFPLEKLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETRDDIAQRLGIPIEQ---VNPKDAKAIVVHGTELKDISREDLDAILADHPEIVFARTSPQQKLIIVEGCQRAGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASI{ADGV}TGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLIFILASIPLPLGVVTILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Sus_scrofa DMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTPARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQAATE-EEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWSDNQIHEADTTENQSSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYTKIVEIPFNSTNKYQLSIHLVMKGAPERILDRCSSILIHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDV-NFPLDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQ---VNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPASKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNEQLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVNWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTPFFVTIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGG-WVEKETYY Tegula_brunnea --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERIMDRCSTVLLNGKEQAIDDSFREAFNAAYLELGGLGERVLGFCDYFLPIDQFAPGYSFDPDGP-NFPITGLRFVGLMAMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGSKTVEDIAAERGIPVEE---VDPREAKAAVVHGADLRDMTPAQIDEILRNHGEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Tenebrio_molitor ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDNQIIEADTTEDQSSPGFKALSRIATLCNRAEFKGGQDNVPILKREVNGDASEAALLKCMELALGDVMSIRRKNKKACEIPFNSTNKYQVSIHLVMKGAPERILERCNTIFICGKEKVLDEEMKEAFNNAYLELGGLGERVLGFCDFMLPTDKYP{IV}GYKFNCDDP-NFPLDGLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSE---VNPREAKAAVIHGSDLRDLSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDVPLPLGTVTILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Terebratalia_transversa ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDNRIVETDTSDDQSTPTWLNLARISMLCNRATFKVDQEDVPVLKRECNGDASESALLKCVELSIGGVTEFRDRNKKVCEIPFNSSNKYQVSVHLVMKGAPERILDRCTTILIDGEERIMDEDTKESFNSAYLELGGLGERVLGFCDYFLPSEQFPVGYEFDADDV-NFPLTKLRFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLGVPVSE---VNPRDAKACCVHGSDLRDMTPAQIDDILKHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLLFILADIPLPLGTITILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Torpedo_californica DLDELKKEVSLDDHKLNLDELHQKYGTDLTQGLTPARAKEILARDGPNALTPPPTTPEWIKFCRQLFGGFSILLWTGAILCFLAYGIQVATV-DNPANDNLYLGVVLSTVVIITGCFSYYQEAKSSKIMDSFKNMVPQQALVIRDGEKSSINAEQVVVGDLVEVKGGDRIPADLRIISACSCKVDNSSLTGESEPQSRSPEYSSENPLETKNIAFFSTNCVEGTARGIVINIGDHTVMGRIATLASGLEVGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSSLSWNALSRIAALCNRAVFQAGQDSVPILKRSVAGDASESALLKCIELCCGSVSQMRDRNPKIVEIPFNSTNKYQLSIHLVMKGAPERILDRCSTILLNGEDKPLNEEMKEAFQNAYLELGGLGERVLGFCHLKLSTSKFPEGYPFDVEEP-NFPITDLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVNQ---VNPRDAKACVVHGTDLKDLSHENLDDILHYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLVFIIANVPLPLGTVTILCIDLGTDMVPAISLAYERAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPIDLIGIREKWDELWTQDLEDSYGQQWTYEQRKIVEYTCHTSFFVSIVIVQWADLIICKTRRNSIFQQGMKNKILIFGLFEETALAAFLSYTPGTDIALRMYPLKPSWWFCAFPYSLIIFLYDEARRFILRRNPGG-WVEQETYY Watersipora_subtorquata ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDDTIYEADTSDEQTNPAWLNLARCAMLCNRAEFKVGQEGVPVLKRECNGDASESALLKCVELSMGHVTEYRARNKKISEIPFNSTNKYQVSIHLVMKGAPERILDRCSTLYMNGKEIAMDDHWRDEFNKAYLQLGGLGERVLGFCDYMLPSQEFPPGYPFDADEE-NFPLTNLRFLGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKGVGIISRDNETVDDIAERLGVPTAE---VNPRDAHAAVVHGGDLRDMNADDIDSILRYHSEIVFARTSPQQKLIIVEGCQRAGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLFFILFDVPLPLGTITILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Xenopus_laevis DMDELKKEVTMEDHKLSLDELHRKFGTDMQRGLTTARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQAAME-EEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRSGEKLSINAEEVVLGDLVEVKGGDRIPADLRVISSHGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVNTGDRTVMGRIATLASGLDGGRTPIAIEIEHFIHIITGVAVFLGVSFFILSLILQYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSSPTWTALSRVAGLCNRAVFQAGQENTPILKRDVAGDASESALLKCIELCCGSVRDMREKNHKVAEIPFNSTNKYQLSVHLVMKGAPERILDRCTSIILQGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLALPDDQFPDGFQFDTEEV-NFPTENLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVNQ---VNPRDAKACVIHGTDLKDMTEEQIDDILRHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGIAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPWTLLGIRVNWDDRWTNDVEDSYGQQWTYEQRKIVEFTCHTSFFISIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPTWWFCAFPYSLIIFIYDEVRKLIIRRSPGG-WVEKESYY brachyceran_dipteran ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDNQIIEADTTEDQSSPGFKALSRIATLCNRAEFKGGQEGVPILKKEVSGDASEAALLKCMELALGDVMNIRKRNKKLAEIPFNSTNKYQVSIHLVMKGAPERILERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDYMLPSDKYPTGFKFNVDDV-NFPIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPVSE---VNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- diplopodan_1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------?QVIEVDTTENQSSPSFKALSRIAALCNRAEFKVNQEDVPVMKRETNGDASESALLKCIEIAVGNVMAMRAKNKKVCEVPFNSTNKYQVSIHLVMKGAPERILGKSSTILLNGKEVPLDEELKDAFNNAYLELGGLGERVLGFCDFKLPKDKYPPGFPFDSDEP-NFQIDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIARSVGIISEGNETVEDIAARLNIPVDR---VNPRDAKACVIHGQDLRDYSAEELNDLLRHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLLFIVADIPLPLGTRNY?------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ diplopodan_2 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNQVIEVDTTENQSSVSFQALARIACLCNRAEFKPGQDEVPVTKRETNGDASESALLKCIEIAVGSVMGIRAKNKKVCEIPFNSTNKYQVSIHMVMKGAPERILERSSTILLQGKEVPLDEELKEAFNNAYLELGGLGERVLGFCDYRLPADKFPRGYPFDADDP-NYPLEGLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIARSVGIISEGNETVEDIASRLNIPLDQ---VDPRDAKAAVIHGQDLRDYSSDELDDILRHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEG{R*}LIFDNLKK{FS}IAYTLTSNIPEISPFLLFIVADIPLPLGTVTILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- nematoceran_dipteran ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDNQIIEADTTEDQSSPGFKALSRIASLCNRAEFKGGQDGVSILKKEVAGDASEAALLKCMELALGDIMGIRKRNKKAAEIPFNSTNKYQVSVHLVMKGAPERVLERCSTIFINGKEKVLDEEMKEAFNNAYLELGGLGERVLGFCDFLLPSDKFPIGFKFNTDDP-NFPLENLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAARLNIPVSE---VNPREAKAAVVHGAELREVSSEQLDEILRYHTEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- oniscidean_isopod -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGWKALSRIAALCNRAEFKTGQENVPIMKKEVNGDASEAALLKCVELAVGDVRKWRTKNKKVCELPFNSTNKYQVSIHLVMKGAPERILERCSTIFIHGEEKPLDDELREAFNNAYLELGGLGERVLGFCDYMLPSDKFPVGYPFDADSV-NFPVHGLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAQRLNIPIKE---VDPREAKAAVVHGSELRDMTGEQLDDILMHHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAAEMILL{DE}DNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLFFMCASVPLPLGTVTILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- opilionid ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDNQIIEADTTEDQSSYGWKALSRVCCLCSRADFKGGQENVPILKRDCTGDASESAILKCMELAIGNVTQYRAKNPKVCEVPFNSTNKYHVTIHLCMKGAPERILERCSTIYISGKEKVLDEEMKEAFNSAYLELGGLGERVIGFCDYILPTDKYPSGYPFDADEG-NFPLSGLRFLGLISMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKAVGIISEGNETVEDIAQRLNIPVEE---VDPRQAKAAVVHGSELRDMQTDLLDDILKYHTEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLFFILADVPLPLGTVTILCIDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ; END;