#NEXUS
[!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file.


Generated on September 20, 2025; 2:26 GMT

TreeBASE (cc) 1994-2008

Study reference:
Weichselbaumer M., Willmann M., Reifinger M., Singer J., Bajna E., Sobanov Y., Mechtcherikova
D., Selzer E., Thalhammer J.G., Kammerer R., & Jensen-jarolim E. 2011.
Phylogenetic discordance of human and canine carcinoembryonic antigen (CEA,
CEACAM) families, but striking identity of the CEA receptors will impact comparative
oncology studies. PLoS Currents: Tree of Life., 16(3): RRN1223.

TreeBASE Study URI:  http://purl.org/phylo/treebase/phylows/study/TB2:S12028]

BEGIN TAXA;
        TITLE  Taxa;
        DIMENSIONS NTAX=9;
        TAXLABELS
            Bos_taurus
            Canis_familiaris
            Danio_rerio
            Gallus_gallus
            Homo_sapiens
            Mus_musculus
            Rattus_norvegicus
            Salmo_salar
            Xenopus_tropicalis
            ;
END;

BEGIN CHARACTERS;
[! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M10610]

	TITLE CEA_receptor_in_human_and_dog;
	LINK TAXA = Taxa;
	DIMENSIONS NCHAR=816;
	FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -;

MATRIX
[                              10        20        30        40        50        60        70        80        90        100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420       430       440       450       460       470       480       490       500       510       520       530       540       550       560       570       580       590       600       610       620       630       640       650       660       670       680       690       700       710       720       730       740       750       760       770       780       790       800       810      ]
[                               .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .      ]
Bos_taurus             --------------------------------------------------------EKRKEKNIKRGGN-RFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTG-GMG----------------------------MGPGGPGMI------------------NIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNLGPAGMGMEGIGFG--INKMGGMEGPFGGGMENMG---RFGSGMNMGRINEI-------LSNALKRGEI--------IAKQGGGGGGGSVPGIER-MGPGIDRIGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGS-VERMGSGIER--MGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMG-LGMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMG--LERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAP-GVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA
Canis_familiaris       --------------------------------------------------------EKRKEKNIKRGGN-RFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTG-GMG----------------------------MGPGGPGMI------------------NIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGMGMEGIGFG--INKMGGMEGPFGGGMENMG---RFGSGMNMGRINEI-------LSNALKRGEI--------IAKQGGGGGGGSVPGIER-MGPGIDRIGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGS-VERMGSGIER--MGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMG-LSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMG--LERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAP-GVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA
Danio_rerio            ALPRGLSGVGLGLGPGGQPIDATQLNRGGMGNMGPGGMDGMGYGGMGRMGGMDNFGESRKERPPKRGGGGRFEPYSNPNKRYSVFVSNIPYDVKWQTLKDLMKEKVGEVTYVEHLMDGEGKSRGCAVVEFRTEELMKKAVEKVNKHVMNGRPLKVKEDPDGVISQREANRGHGGGGGGGGPPGMGGGMGGGMGGGMGGMG------MGPGPGSSSMV------------------NIPPSLMNNPNIPNEVIHGLQAGKIGSTIFVANLDYKVGWKKLKEVFGMAGMVVRADILEDKDGKSRGMGTVTFDMPIEAVQAVSMFNGQLLFNRVMHVKLDEKSLPKGDFAPPER---------------APGG----------GGGG------------------------------GGMNNMD---RFGP-SGMGRMNDMDRG----MGGGFDRDFS----------------------GRND-MGMSRSNFG----DSFDRGMGNSMG-----MDRMNSGMDRLSGGIDRMGGGGGGGGMDRMGGGGGGGGMDRMSD--------LDRMG----SSFDRMGSGLDRLGPSMDRMGSGLDRMSTSVDRMGPGGFDRLGSS-----------SMDRMSGGMDFASPMGM-----DRMNTG-LDRMGSNFDRMGSGGMDRFSS-GLDRMGSSMDRMGSGGIG---GQFDRPGDMDRGNFGSPFGGSGQGGGPGSGGANARKGCQIFVRNLPFDFTWKMLKDTFNSCGMVQYADIKMENGKSKGCGVVRFDNPETAERACRTMNGYRLNGREIDVRIDRNA
Gallus_gallus          --------------------------------------------------------EKRKEKSVKRGGN-RFEPYANPAKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLGGRPLKVKEDPDGEHARRAMQKVMAAGGMGIG----------------------------PGPGGPGMI------------------NIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGAVVRADILEDKDGKSRGIGTVTFEQAIEAVQAISMFNGQLLFDRPMHVKMDERAFPKGDFFPPERPQQLPR----------------------------------MGMEGMGFG--MNKMGGMEGPFGG-MENIG---RFPAGMNMGRMSEMDRAMGGGFEREFGRNEMGMSRSFGETLERGIGGGNASIPGIER-MAPGIDRMG-SGIERIPSGMGHGMERVGSEIDRMGLVLDRMSSNVDRIGSGIDR--MAPLGIDHIAPNIERMGPAIERMGSGIERMGSGIGFGIERMGAAIDRVGTTMDRMGSGVERMGSGMDRMG-IGMERMVPAGMGTG---MGQVIERMPAGLDRIGATPMERIGIDRMGAASMERMG--LERIGATNMERMGPAMGQGMGAGIDRMGLAMG----SNFERTMEMERGNFAGNFAGSLGGTGGPAA-GVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVRFESPEVAERACRMMNGIQLRGREIDVRIDRNA
Homo_sapiens           --------------------------------------------------------EKRKEKNIKRGGN-RFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTG-GMG----------------------------MGPGGPGMI------------------TIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGMGMEGIGFG--INKMGGMEGPFGGGMENMG---RFGSGMNMGRINEI-------LSNALKRGEI--------IAKQGGGGGGGSVPGIER-MGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGS-VERMGSGIER--MGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMG-LSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMG--LERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAP-GVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA
Mus_musculus           --------------------------------------------------------EKRKEKNIKRGGN-RFEPYSNPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTG-GMG----------------------------MGPGGPGMI------------------NIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGIVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLSKGIGMGNLGPAGMGMEGIGFG--INKIGGMEGPFGGGMENMG---RFGSGMNMGRINEI-------LSNALKRGEI--------IAKQGGGGAGGSVPGIER-MGPGIDRISGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGS-VERMGSSIER--MGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMG-LSMDRMVPTGMGASLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMG--LERMGANSLERMGPAMGPALGAGIERMGLAMGGAGGASFDRAIEMERGNFGGSFAGSFGGAGGHAP-GVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA
Rattus_norvegicus      --------------------------------------------------------EKRKEKNIKRGGN-RFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTG-GMG----------------------------MGPGGPGMI------------------NIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHVKMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNLGPAGMGMEGIGFG--INKIGGMEGPFGGGMENMG---RFGSGMNMGRINEI-------LSNALKRGEI--------IAKQGGGGAGGSVPGIER-MGPGIDRISGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGS-VERMGSGIER--MGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMG-LSMDRMVPTGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMG--LERMGANSLERMGPAMGPALGAGIERMGLAMGGAGGASFDRAIEMERGNFGGSFAGSFGGAGGHAP-GVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA
Salmo_salar            --------------------------------------------------------NTRKERPQKRGGG-RFEPYGNPSKRYRVFVSNIPYDVKWQALKDLMKEKVGEVTYVEHLMDGEGKSRGCAIVEFRTEELMKKAVEKVNKHNLNGRPLKVKEDPDGVIAQRDLHRAQGGGGGG--PPGGHGGMNMGMGMDRMNMERMNMDCMGPGPGGPPMV------------------NIPPSLMNNSNIPNEIIHGLQAGKIGSTVFVANLDYKVGWKKLKEVFGMAGVVVRTDILEDKDGNSRGMGTVTFDMPIEAVQAVSMFNGQLLFNRVMHVKLDEKSLPKGDFAPPERPPALPRGLSGIGQGLGPGGQPIDATALNRGGGGGMGNMGPGGMDGMGFGGGMGRMGGMDN-FGGGMNNME---RFGP-SGMGRMNDMDHG----IGGAFDREC-----------------------GRNE-MGMSRNNFG----ESFDRGMGSSLG-----MDRMSSGMDRLGGGMDRLGG------MERM---------DRVSD--------LDRLGG---SGFDRMGSGLDRLGPSMDRLGSGLDRMSSSMDRLGPAGFDCLGPS-----------SLDRMSTGLDFASPMGMA----DRMNTG-MERMGTNFDRMGSAGMDRFPTTGLDRMGSAMDHMGAAGVG---GQYDRPAEMERGGFG--------GNGFGGAGANARKGCQIFVRNLPYDFTWKVLKDTFNTCGMVQYADIKTENGKSKGCGVVRFDNPETAERACRTMNGYRLNGREIDVRIDRNA
Xenopus_tropicalis     --------------------------------------------------------DKRKEKGMKKSSN-RFEPYN-PQRRFRAFISNIPFDVKWQALKDLVKEKVGEVTYVELLMDDEGKSRGCAAVEFKLEESMKKAVQVLNKHVFNGRPLKVREDPDGDRSRRAAHSVFGLGPMGMGGPGPMGLGGPGP----------MGMPGPMGMGGPGPIGLGGPGPLGMGGPGPVGGNIPPSLLNNPNIPREVIHALQAGRLGSTVFVANLDYSVGWKKLKEVFGIAGTVLRADVLEDKDGKSRGIGTVTYEQPIEAVQAISMFNGQPLFDRPMMVKMDDKSMPKGDLFPADRPPQLPRGLGGIGMGLGPGGQPIDANHLR---GSSMGGPGGISMDSMGFG--MNKMG-IDGPPVGGNSSLGSINRFPSGLGLGRMSGDLDR---AMSVGFDRSELN-------TLSRGYG------DSLDRGIGSGAGNLV-AGIDRLSSGLGRGVDRVPSDIDRMGLVMDRLGPSADRMGSGIGSG-MGSLGMDHISSSIDRI------VASSLDRMSTNIGYGVDRMGSSIDRVGSTIDRMGSSIDRIGSGMDRVG-VGMDRLGSS-----------SMDRMASGLDRMGPMMDRLPSVDRLTAGSMNRVG--LDHIASSPLDRMGPGIG--MGS---SMGLGMG----SSFDRPMDIDHTKFGNNFGGSFGGTAGIRPVAVPRKGCQIFVRNLSFDCTWKMLKDQFGECGHVVYADIKTENGKSKGCGVVRFESPEVAERACRMMNGAKLGGREIDVRMDRNA
;
END;