#NEXUS
[!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file.


Generated on September 18, 2025; 21:25 GMT

TreeBASE (cc) 1994-2008

Study reference:
D'angelo M.E., Dunstone M.A., Whisstock J.C., Trapani J.A., & Bird P.I. 2012. Perforin
evolved from a gene duplication of MPEG1, followed by a complex pattern of
gene gain and loss within Euteleostomi. BMC Evolutionary Biology, 12(1).

TreeBASE Study URI:  http://purl.org/phylo/treebase/phylows/study/TB2:S12411]

BEGIN TAXA;
        TITLE  Taxa;
        DIMENSIONS NTAX=12;
        TAXLABELS
            Anolis_carolinensis_C6
            Anolis_carolinensis_MPEG1
            Anolis_carolinensis_PRF1
            Homo_sapiens_C6
            Homo_sapiens_MPEG1
            Homo_sapiens_PRF1
            Mus_musculus_C6
            Mus_musculus_MPEG1
            Mus_musculus_PRF1
            Takifugu_rubripes_C6
            Takifugu_rubripes_MPEG1
            Takifugu_rubripes_PRF1.2
            ;
END;

BEGIN CHARACTERS;
[! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M11730]

	TITLE 'MPEG1-perforin-C6';
	LINK TAXA = Taxa;
	DIMENSIONS NCHAR=269;
	FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -;

MATRIX
[                                     10        20        30        40        50        60        70        80        90        100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260         ]
[                                      .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         ]
Anolis_carolinensis_C6        INRVCKRFIPSAQLMGLGYHILADESRGEVLDYSFHGCVRVKSETYRVPANLENFQNQEDDVKAHYYTDLTPIMQTGNSMVSSSSHKMSSNFIRVHKVIAVSNFTVKQSDQVSRVFLNALNSLPLEYNYALYSRIFDDFGTHYYTSGSLGYQFNEEETKNSGLTQEEITNCVETTFYIIPIRHEECTRSKMTERYEGSVLKSSERSISLVKGGQYAAALAFEKKNIFNNWLESTKENPGVIEFEVASILDLVKCAVTKRYNLRKAFFEY
Anolis_carolinensis_MPEG1     GFQECRQLGRPALEVLPGGGWDNLQNRARVIHLNYSLCRTTEDGAYLIPNDVFPLKETYLELNSEIIESWMDYQSASTSFINGKTHQVKDQTVTTRVQVRNRMYTVKFDPRFDEGFQQQLVAIASHLENYLAEILVLNYGTHVITGVDAGASLIQEDQVRSTFVKDSKFMRSTAAAGVHKVVNFQSSLSVGIDDSFIQYEANRTNSRVESIGGPFYPGITLKTWESIPNRLVAIDRFGLPLEFFITPEKLPGLIVKRLSKTVASAITRY
Anolis_carolinensis_PRF1      TEDECQDQHPGHGLAGVGFDITKLERKAVLDMSQWQKCTLCQNPLQRLPLAIAEAKACQKNLRSSIQVSGISAVQAQALAGSHKSSQDQYTFVSHEVSCSYYSLRIGHRRKLAEHFRHALKTLPLKYNRLEYHQLIGTYGTHWITHLRLGTATRVCETVLDGVTADEVKDCLEASASIRNSSSYKMCQELKKKQNFKSFHNTYNERHTEVVGGASHVDLLFSNDESFKEWLEGLKSLPDLLSYSLEPIHTLVRKGHPKRESLRQAVSEY
Homo_sapiens_C6               TKAVCTRYNPSVQLMGNGFHFLAGEPRGEVLDNSFTGCKTVKSSPYRVPANLEGFETAEDDLKTDFYKDLTSLGHNKSENINHASHKKDSSFIRIHKVMKVLNFTTKAKDHLSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGYQFSSEELKNSGLTEEEAKHCVETKKRVAKKVEHRCTTNKLSEKHEGSFIQGAEKSISLIRGGEYGAALAWEKGKTFSEWLESVKENPAVIDFELAPIVDLVRCAVTKRNNLRKALQEY
Homo_sapiens_MPEG1            GVQKCKNLKLPVLEVLPGGGWDNLRNVDRVMELTYSNCRTTEDGQYIIPDEIFPQKQSNLEMNSEILESWANYQSSSFSKVNGKTLQVKDQAITTRVQVRNLVYTVKINPELSSGFRKELLDISDRLENYLAELLVLNYGTHVTTSVDAGAALIQEDHLRASFLQDSQSSRSTASAGLQNTVNFKFEENYTSQNVLTSYLSNRTNSRVQSIGGPFYPGITLQAWQGITNHLVAIDRSGLPLHFFINPNMLPDLLVKKVSKTVETAVKRY
Homo_sapiens_PRF1             ARSECKRHKPGAWLAGEGVDVTSLRRSGPVDTQRFLRCTLCENALQRLPLALTRAQGCQRHVTRAKVSSTEAVARDHSVAGSHKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNAPAYLRLISNYGTHFIRAVELGTALRTCELALEGLTDNEVEDCLEAQVNIHGSAEAKACEEKKKKHKMTSFHQTYRERHSEVVGGTSINDLLFGIQEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREALRRALSQY
Mus_musculus_C6               TKPVCTRYTPSVQLMGTGFHFLAGEPRGEVLDNSFTGCKLVKTSPYRVSANLENFETIEDDLKTEFYKNLISFEKNENEHSHYASHKKDSSFIRIHKLIKVLNFTMKATDQLSDVFLKALVHLPLEYNSAVYSRIFDDFGTHYFTSGSLGYQFSRQELQNSGLTEEEAQNCVETKKLKYMEKEDTCTKNKLSEKYGGSFLQGSEKSISLVQGGQQAAALAWEKGNVYSEWLESVKENPAVVDYKLAPITDLVRCAVTKRNNLRRALQEY
Mus_musculus_MPEG1            GFQICKNLKLPVLEVLPGGGWDNLRNVDRVMDLTYTNCKTTEDGQYIIPDEVYPQKESNLEMNSEVLESWMNYQSTAFSRVNGKTLQVKDQAVTTRVQVRNRIYTVKTTPELSLGFTKALMDICDQLEKYLAELLILNYGTHVITSVDAGAALVQEDHVRSSFLLDNQNSQNTASAGILNIVNFKVETDYISQTSLTDYLSNRTNSRVQSFGGPFYPGITLETWKGITNHLVAIDRAGLPLHFFIKPDKLPGLLVKKLSKTVETAVRHY
Mus_musculus_PRF1             TRSECKQHKPGVWMAGEGMDVTTLRRSGPVNTQRFLRCTLCKNSTQRLPVAITRPHHCQRNVAAAKVHSTEGVARERSVAGSHKTYQDQYNFNSDTVECRMYSFRLVQKPPLHLDFKKALRALPRNFNSHAYHRLISSYGTHFITAVDLGTALRTCQLTLNGLTADEVGDCLEAQVSIQASSEYKACEEKKKQHKMASFHQTYRERHVEVLGGDSTHDLLFGNQEQFSTWTASLPSNPGLVDYSLEPLHTLLEEQNPKREALRQAISHY
Takifugu_rubripes_C6          FKTVCPAKRPGADLVGNGFDAMAEEPRGAVLDNMFMGCNIKRPQYHRIPHNFANFDDHYERLEVTFLPSLAGSEPESSPYAENLFRDKDSKFLRVHQVLPVSTFKMMDSEVLSQPFLQFLHALPLEYNYALYREIFQRFGTHYYHSGVLGYQYSREELKSSGTTEEHIRGCSSTAQIPQEGPLLEVVSNQIQIQFNTSYIQAAEKSYSMVRGGREAAALAWERQVSFKNWAKSVLDNPAVVESTVNPIIDLVRCAVTKRRHLRKALLQY
Takifugu_rubripes_MPEG1       WLRQCRETNITALEVLPGGGWDNLRNMDRVMNISYFQCQTTEDGLYLIPDEVFPHKETGVETNSEIISSWLEQKSCSFSVLNGKTHQVKDSSITTRVQIRNFIYKVKAFPALDVRFAQQAKEIADAIENYLSEKMVLEFGTHVITSVDAGATLVEEDYLTAKYVSDATSKSSTAQAGLFDKLKFDISSQTSTQSSILGYQSNITYSIIQSHGGPFYPGMTLQKWESTRNNLVAIDRSGMPLQYFINPNTFPDLTVRKVSRSVRQAIDRY
Takifugu_rubripes_PRF1.2      SFTECQNAPPGHNLVGEGFDVVTMKTSGVVDVKTFMVCTMCHNSAQKLPVSVLRVKNCQRSLSSKIFESSQAVMKEGSVGGSHHSRQDKFSFTSYEMKCRYYTFRLHARPPLSKEFEVSLKNLPPTYDHSAFRQFISVYGTHFIRRVHLGTAIRTCQASISQMSVHTVSNCLEAEATIKGVAASRFCQSKSKSLKTGTFSQAFSDRTTDVLGGESVGDILFQPNAAFKKWLISLKKVPGLVSYQLSPLHLLVPDNPVLQESLRSAISDY
;
END;