#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 18, 2025; 21:23 GMT TreeBASE (cc) 1994-2008 Study reference: Passamaneck Y., & Martindale M. 2013. Evidence for a phototransduction cascade in an early brachiopod embryo. Integrative and Comparative Biology, . TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S14096] BEGIN TAXA; TITLE Taxa; DIMENSIONS NTAX=32; TAXLABELS Drosophila_melanogaster_TRP_NP_ Drosophila_melanogaster_TRP_like Homo_sapiens_TRPA1_C Homo_sapiens_TRPC1_A Homo_sapiens_TRPC3_A Homo_sapiens_TRPC4_A Homo_sapiens_TRPC5_A Homo_sapiens_TRPC6_A Homo_sapiens_TRPC7_C Homo_sapiens_TRPM1_A Homo_sapiens_TRPM2_B Homo_sapiens_TRPM3_C Homo_sapiens_TRPM4_A Homo_sapiens_TRPM5_A Homo_sapiens_TRPM6_A Homo_sapiens_TRPM7_A Homo_sapiens_TRPM8_A Homo_sapiens_TRPML1_ Homo_sapiens_TRPML2_ Homo_sapiens_TRPML3_ Homo_sapiens_TRPP1_A Homo_sapiens_TRPP2_A Homo_sapiens_TRPP3_A Homo_sapiens_TRPP4_A Homo_sapiens_TRPP5_A Homo_sapiens_TRPV1_A Homo_sapiens_TRPV2_C Homo_sapiens_TRPV3_A Homo_sapiens_TRPV4_C Homo_sapiens_TRPV5_C Homo_sapiens_TRPV6_A Terebratalia_transversa_TRPC ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M16618] TITLE TRP; LINK TAXA = Taxa; DIMENSIONS NCHAR=601; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 ] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] Drosophila_melanogaster_TRP_NP_ -TDPMNRSALISAIEN--EN-FDLMVILLE-HN--IE---------------V-GDALLHAISEEYV---------------------EAVEELLQWEETNHK--------EG--QPYSTFTV--------DITPLILAAHRNNYEILKILLDR------G---AT---LPMPHDV--KCGCDECVTSQMTDSLRHSQSR-RKPFVKFITHSCSYMFFLMLLGAALP-GPIELAIITYIMALI---FEELKSLYSD-------------------GLFEYIMD-----LWNIVDYISNMFY---VTWILCRATAWVIVHRDL-WF-R---------------GIDP---YFPREHWHPFDPMLL--SE-GAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMI-IDIIKFFFIYTLVLFAFGCGLNQLLWYYAELEK-----N-KCYHLHPDVADFDDQEKAC-TIWRRFSNLFE---TSQSLFWASFGLVDLVSF--DL--AGIK------------------------------------SF-TRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTE--WKFARSQLWMS Drosophila_melanogaster_TRP_like -MDPLGRRALTLAIDN--EN-LEMVELLVV-MG--VE---------------T-KDALLHAINAEFV---------------------EAVELLLEHEELIYK--------EG--EPYAMFAP--------DITPLMLAAHKNNFEILRILLDR------G---AA---VPVPHDI--RCGCEECVRLTAEDSLRHSLSR-RKPFMKFLIHASSYLFFLFILILVTP-SKLELIVVMYVIGFV---WEEVQEIFAV-------------------GMKSYLRN-----MWNFIDFLRNSLY---VSVMCLRAFAYIQQATEI-AR-D---------------PQMA---YIPREKWHDFDPQLI--AE-GLFAAANVFSALKLVHLFSINPHLGPLQISLGRMV-IDIVKFFFIYTLVLFAFACGLNQLLWYFAALEK-----S-KCYVLPGGEADWGSHGDSC-MKWRRFGNLFE---SSQSLFWASFGMVGLDDF--EL--SGIK------------------------------------SY-TRFWGLLMFGSYSVINVIVLLNLLIAMMSNSYAMIDEHSDTE--WKFARTKLWMS Homo_sapiens_TRPA1_C -EGENGNTAVIIACTT--NN-SEALQILLN-KGAKPCRQLHINFMNNG-K----ATPLHLAVQNGDL---------------------EMIKMCLDNGAQIDP--------VE--KGRKIDSE--------GRSPLILATASASWNIVNLLLSK------G---AQ---VDIK----------------------------ET----------------------YLIKTCMIL---VFLSSIFGYCKEAGQIFQ--------------------QKRNYFMD-----ISNVLEWIIYTTGIIFVLPLFVEIPAH------------------------------------------------L--QW-QCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVIL-KTLLRSTVVFIFLLLAFGLSFYILLN-L----------------------------------QDPFSSPLL---SIIQTFSMMLGDINYRESFLEPYLRNEL------------------------------------AH--PVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLK--RIAMQVELHTS Homo_sapiens_TRPC1_A -VDVLGRNAVTITIEN--EN-LDILQLLLD-YG--CQ---------------S-ADALLVAIDSEVV---------------------GAVDILLNHRPKRSS--------RP--TIVYSTTM--------DVAPVILAAHRNNYEILTMLLKQ------D---VS---LPKPHAV--GCECTLCSAKNKKDSLRHSRFR-HTPFMKFIIHGASYFTFLLLLNLYAL-ERIDYLLILWIIGMI---WSDIKRLWYE-------------------GLEDFLEE-----SRNQLSFVMNSLY---LATFALKVVAHNKFHD-----------------------------FADRKDWDAFHPTLV--AE-GLFAFANVLSYLRLFFMYTTSSILGPLQISMGQML-QDFGKFLGMFLLVLFSFTIGLTQLYDKGYTS----KEQK-DCVGI---F-----C--EQ-QSNDTFHSFIG---TCFALFWYIFSLAHVAIFVTRF--SYGE------------------------------------EL-QSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKE--WKFARAKLWLS Homo_sapiens_TRPC3_A -VDYMGQNALQLAVGN--EH-LEVTELLLK-KENLAR---------------I-GDALLLAISKGYV---------------------RIVEAILNHPGFAAS--------KR--LTLTRFSP--------DITPIILAAHCQKYEVVHMLLMK------G---AR---IERPHDY--FCKCGDCMEKQRHDSFSHSRSR-RSPFMKFVAHAASFIIFLGLLVFNQF-TWTEMLIMVWVLGMM---WSECKELWLE-------------------GPREYILQ-----LWNVLDFGMLSIF---IAAFTARFLAFLQATKAQ-QY-VDSYVQESDLSEVTLPPEIQYF-TYARDKWLPSDPQII--SE-GLYAIAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVLFIMVFFAFMIGMFILYSYYLGAK-----------------------------VNAAFTTVEE---SFKTLFWSIFGLSEVTSV--VL--KYDH------------------------------------KF-IENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVE--WKFARSKLWLS Homo_sapiens_TRPC4_A -IDPLGRTALLIAIEN--EN-LELIELLLS-FN--VY---------------V-GDALLHAIRKEVV---------------------GAVELLLNHKKPSGE--------KQ--VPPSEFTP--------DITPIILAAHTNNYEIIKLLVQK------G---VS---VPRPHEV--RCNCVECVSSSDVDSLRHSRSR-RKPFIKFICHTASYLTFLFLLLLAPP-TIVEWMILPWVLGFI---WGEIKQMWDG-------------------GLQDYIHD-----WWNLMDFVMNSLY---LATISLKIVAFVKYSA-----------------------------LNPRESWDMWHPTLV--AE-ALFAIANIFSSLRLISLFTANSHLGPLQISLGRML-LDILKFLFIYCLVLLAFANGLNQLYFYYEETKG-----L-TCKGI---R-----C---E-KQNNAFSTLFE---TLQSLFWSIFGLINLYVT--NV--KAQH------------------------------------EF-TEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIE--WKFARTKLWMS Homo_sapiens_TRPC5_A -MDPLGRSALLIAIEN--EN-LEIMELLLN-HS--VY---------------V-GDALLYAIRKEVV---------------------GAVELLLSYRRPSGE--------KQ--VPTSEFTP--------DITPIMLAAHTNNYEIIKLLVQK------R---VT---IPRPHQI--RCNCVECVSSSEVDSLRHSRSR-KKPFIKFICHTASYLTFLFMLLLAPP-TVVEWMILPWVLGFI---WGEIKEMWDG-------------------GFTEYIHD-----WWNLMDFAMNSLY---LATISLKIVAYVKYNG-----------------------------SRPREEWEMWHPTLI--AE-ALFAISNILSSLRLISLFTANSHLGPLQISLGRML-LDILKFLFIYCLVLLAFANGLNQLYFYYETRAI--DEPN-NCKGI---R-----C---E-KQNNAFSTLFE---TLQSLFWSVFGLLNLYVT--NV--KARH------------------------------------EF-TEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIE--WKFARTKLWMS Homo_sapiens_TRPC6_A -VDYMGQNALQLAVAN--EH-LEITELLLK-KENLSR---------------V-GDALLLAISKGYV---------------------RIVEAILSHPAFAEG--------KR--LATTRFSH--------DVTPIILAAHCQEYEIVHTLLRK------G---AR---IERPHDY--FCKCNDCNQKQKHDSFSHSRSR-RGPFMKFVAHAASFTIFLGLLVMNCF-SWMEMLIISWVIGMI---WAECKEIWTQ-------------------GPKEYLFE-----LWNMLDFGMLAIF---AASFIARFMAFWHASKAQ-SI-IDANDTLKDLTKVTLGDNVKYY-NLARIKWDPSDPQII--SE-GLYAIAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAK-----------------------------QNEAFTTVEE---SFKTLFWAIFGLSEVKSV--VI--NYNH------------------------------------KF-IENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVE--WKFARAKLWFS Homo_sapiens_TRPC7_C -VDYMGQNALQLAVGN--EH-LEVTELLLK-KENLAR---------------V-GDALLLAISKGYV---------------------RIVEAILNHPAFAQG--------QR--LTLTRFSH--------DITPIILAAHCQEYEIVHILLLK------G---AR---IERPHDY--FCKCNECTEKQRKDSFSHSRSR-RSPFMKFVAHAVSFTIFLGLLVVNQF-SWTEMLIMKWVLGMI---WSECKEIWEE-------------------GPREYVLH-----LWNLLDFGMLSIF---VASFTARFMAFLKATEAQ-LY-VDQHVQDDTLHNVSLPPEVAYF-TYARDKWWPSDPQII--SE-GLYAIAVVLSFSRIAYILPANESFGPLQISLGRTV-KDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAK-----------------------------YNPAFTTVEE---SFKTLFWSIFGLSEVISV--VL--KYDH------------------------------------KF-IENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVE--WKFARAKLWLS Homo_sapiens_TRPM1_A ICDGSGRASDILSFAH--KY-CEEGGIINESLR----EQLLVTIQKTFN-YNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAILTALLKGT-NVSA-------PDQLSLALQIFVFGPHWTPNALEQAMLDALVLDRVDFVKLLIEN------G---VN---MQHFLTIPRLE---ELYN--TRLGPPNT-LHLNAPIVKFWFYTISYLGYLLLFNYVWP-SLQEWIVISYIVSLA---LEKIREILMSEPG------------KLSQKIKVWLQE-----YWNITDLVAISTF---MIGAILRLQN----------------------------------------------QPYMGYGR-VIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMM-IDMLYFVVIMLVVLMSFGVARQAILHPEEK---------------------------------PSWKLARN---IFYMPYWMIYGEVFADQI--DLYAM-EIN-------PPCGENLYDEEGKRLP----------PCIP-GAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQV--WKFQRYQLIMT Homo_sapiens_TRPM2_B VVEGSGRVADVIAQVA--NL-PVSDIT-ISLIQ----QKLSVFFQEMFETFTESRIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKAS-RSQDHFGHENWDHQLKLAVEIFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLEN------G---VQ---LKEFVTWDTLL---YLYE--NL--DPSCLFHSTAPVVVFHLNILSYFAFLCLFAYVVP-SWCECAIYLWLFSLV---CEEMRQLFYDPDEC-----------GLMKKAALYFSD-----FWNKLDVGAILLF---VAGLTCRLIPA-----------------------------------------------TLYPGR-VILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMM-KDVFFFLFLLAVWVVSFGVAKQAILIHNER---------------------------------RVDWLFRG---AVYHSYLTIFGQIPGY-I--DGVNFNPEHCSPNGTDP------------YKPKCPESDATQQRPAF-PEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQI--WKFQRHDLIEE Homo_sapiens_TRPM3_C VCDGSGRASDILAFGH--KY-SEEGGLINESLR----DQLLVTIQKTFT-YTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGA-NASA-------PDQLSLALQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIEN------G---VS---MHRFLTISRLE---ELYN--TRHGPSNT-LYHNAPIVKFWFYTLAYIGYLMLFNYIWP-STQEWIVISYIFTLG---IEKMREILMSEPG------------KLLQKVKVWLQE-----YWNVTDLIAILLF---SVGMILRLQD----------------------------------------------QPFRSDGR-VIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMM-IDMMYFVIIMLVVLMSFGVARQAILFPNEE---------------------------------PSWKLAKN---IFYMPYWMIYGEVFADQI--DPPCGQNET-------REDGKI------IQLP----------PCKT-GAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQV--WKFQRYQLIMT Homo_sapiens_TRPM4_A LVAGSGGAADCLAETL--ED-TLAPGS-GGARQ----GEARDRIRR---FFPKGDLEVLQAQVERIMTRKELLTVYSS-EDGSEEFETIVLKALVKAC-GSSEA---SAYLDELRLAVELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISH------G---LS---LGHFLTPMRLA---QLYS--AA--PSNSLIRNGAPVTIFMGNVVSYLLFLLLFSRVPP-GSLELLLYFWAFTLL---CEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLAD-----SWNQCDLVALTCF---LLGVGCRLTPG-----------------------------------------------LYHLGR-TVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMM-KDVFFFLFFLGVWLVAYGVATEGLLRPRDS---------------------------------DFPSILRR---VFYRPYLQIFGQIPQEDM--DVALMEHSNCSSEPGFW------------AHPPG--AQAGTCVSQY-ANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLY--WKAQRYRLIRE Homo_sapiens_TRPM5_A ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAPVTVFLGNVVMYFAFLFLFTYVGP-SGPEVTLYFWVFTLV---LEEIRQGFFTDEDT-----------HLVKKFTLYVGD-----NWNKCDMVAIFLF---IVGVTCRMLPS-----------------------------------------------AFEAGR-TVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMM-KDVFFFLFFLSVWLVAYGVTTQALLHPHDG---------------------------------RLEWIFRR---VLYRPYLQIFGQIPLDEI--DEARVN---CSTHPLLL-------------------EDSPSCPSLY-ANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMF--WKFQRYNLIVE Homo_sapiens_TRPM6_A VCEGTGRAADLLAFTH--KH-LADEGMLRPQVK----EEIICMIQNTFN-FSLKQSKHLFQILMECMVHRDCITIFDADSEEQQDLDLAILTALLKGT-NLSA-------SEQLNLAMHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEY------G---VN---LHRFLTIPRLE---ELYN--TKQGPTNTLLHHSAPIVKFWFYTMAYLAFLMLFTYTQP-SVQEWLVSIYIFTNA---IEVVREICISEPG------------KFTQKVKVWISE-----YWNLTETVAIGLF---SAGFVLRWG----------------------------------------------DPPFHTAGR-LIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMT-ANMFYIVIIMAIVLLSFGVARKAILSPKEP---------------------------------PSWSLARD---IVFEPYWMIYGEVYAGEI--DVCSSQPSC-----------------------------------PP-GSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNL--WKYNRYRYIMT Homo_sapiens_TRPM7_A VCEGTGRAADLLAYIH--KQ-TEEGGNLPDAAE----PDIISTIKKTFN-FGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGT-NASA-------FDQLILTLHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIEN------G---VS---MHKFLTIPRLE---ELYN--TKQGPTNPMLFHHAPIVKFWFNTLAYLGFLMLYTFVLP-SVQEWIVIAYIFTYA---IEKVREIFMSEAG------------KVNQKIKVWFSD-----YFNISDTIAIISF---FIGFGLRFGAKWNFAN-------------------------------------AYDNHVFVAGR-LIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMV-ANMFYIVVIMALVLLSFGVPRKAILYPHEA---------------------------------PSWTLAKD---IVFHPYWMIFGEVYAYEI--DVCANDSVI-------PQ------------------------ICGP-GTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIV--WKYQRYHFIMA Homo_sapiens_TRPM8_A VVEGSGQIADVIASLV--E---VEDALTSSAVK----EKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIKMEEAGDEIVSNAISYALYKAF-STSEQ-DKDNWNGQLKLLLEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN------G---LN---LRKFLTHDVLT---ELFS--NH--F-STLVYRTSPFVVFSWNVVFYIAFLLLFAYVVP-HPPELVLYSLVFVLF---CDEVRQWYVN--------------------GVNYFTD-----LWNVMDTLGLFYF---IAGIVFRLHSSN--------------------------------------------KSSLYSGR-VIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRML-IDVFFFLFLFAVWMVAFGVARQGILRQNEQ---------------------------------RWRWIFRS---VIYEPYLAMFGQVPSD-V--DGTTYDFAHCTFTG-NE------------SKPLCVEL-DEHNLPRF-PEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQV--WKFQRYFLVQE Homo_sapiens_TRPML1_ ------SNQLAVTFRE--EN-TIAFRHLFL-LGYSDG------AAYTREQ--L-YQAIFHAV-DQYL---------------------ALPDVSLGRYAYVRG--------GG--DP--NDTF--------DIDPMVVTDCIQVD-PPE----R-PPPPPS---DDLTLLESS----------------------------QN----------------------------------EFVGFMWRQ--RGRVISL--------------------WERLEFVN-----GWYILLVTSD---VLTISGTIMKIGIEAKNL----------------------------------ASYD------V--CS-ILLGTSTLLVWVGVIRYLTFFHNYNILIATLRVAL-PSVMRFCCCVAVIYLGYCFCGWIVLGPY----------------------------------HVKFRSLSM---VSECLFSLINGDDMFV-TFAAMQAQQGR------------------------------------SSLVWLFSQLYLYSFISLFIYMVLSLFIALITGAYDTIKHPGGAG--AEESELQAYIA Homo_sapiens_TRPML2_ ------SNQLVVAFKE--DN-TVAFKHLFL-KGYSGT------SVYTQED--A-YESIFFAI-NQYH---------------------QLKDITLGTLGYGEN--------E-------NETL--------NIDNDVELDCVQLD-LQD----L-SKKPP----------DW-----------------------------RK----------------------------------RFLNFFLEK--YKRPVCD--------------------TDQWEFIN-----GWYVLVIISD---LMTIIGSILKMEIKAKNL----------------------------------TNYD------L--CS-IFLGTSTLLVWVGVIRYLGYFQAYNVLILTMQASL-PKVLRFCACAGMIYLGYTFCGWIVLGPY----------------------------------HDKFENLNT---VAECLFSLVNGDDMFA-TFAQI---QQK------------------------------------SILVWLFSRLYLYSFISLFIYMILSLFIALITDSYDTIKKFQQNG--FPETDLQEFLK Homo_sapiens_TRPML3_ ------SNQMVVAFKE--EN-TIAFKHLFL-KGYMDR------AVYTQSD--V-YDQLIFAV-NQYL---------------------QLYNVSVGNHAYENK--------G-------NDTF--------DIDPEIETECFFVE-PDE----PFHIGTP-----------A-----------------------------QQ----------------------------------EFVNFFLLH--YKKEVSV--------------------SDQMEFVN-----GWYIMIIISD---ILTIIGSILKMEIQAKSL----------------------------------TSYD------V--CS-ILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAAL-PNVIRFCCCAAMIYLGYCFCGWIVLGPY----------------------------------HDKFRSLNM---VSECLFSLINGDDMFA-TFAKM---QQK------------------------------------SYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDG--FPETELRTFIS Homo_sapiens_TRPP1_A ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPL-LTSVCLLLFAVHFA---VAEARTWHRE-------------------G-RWRVLR-----LGAWARWLLVALT---AATALVRLAQ-LGAADR--QW-TRFVRG----------RPRRFTSFDQVAHVS-----SA--AR-GLAASLLFLLLVKAAQHVRFVRQWSVFGKTLCRA-LPELLGVTLGLVVLGVAYAQLAILLVSSC----------------------------------VDSLW---S---VAQALLVLCPGTG-LST-LC--------------------------------------------PAESWHLSPLLCVGLWALRLWGALRLGA------------------------------ Homo_sapiens_TRPP2_A LRGLWGTRLMEESSTN--RE-KYLKSVLRE-LV----TYLLF-LIVLCI-LTYGMMSSNVYYYT------------------------RMMSQLFLDTPVSK--------TEK-----------------------------T----------------------------------------------------------RATFIDFSVYNANINLFCVVRLLVF-LAACEIIFCFFIFYYV---VEEILEIRIH--------------------KLHYFRS-----FWNCLDVVIVVLS---VVAIGINIYRTSNVEVLL-QFLE---------------DQNTFPNFEHLAYWQI-----Q--FN-NIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCA-KDLFGFAIMFFIIFLAYAQLAYLVFGT-Q---------------------------------VDDFSTFQE---CIFTQFRIILGDINF-------A--EIE------------------------------------EA-NRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQK-AEMELSDLIRK Homo_sapiens_TRPP3_A IRGLWGTTLTENTAEN--RE-LYIKTTLRE-LL----VYIVF-LVDICL-LTYGMTSSSAYYYT------------------------KVMSELFLHTPS----------DTG-----------------------------V----------------------------------------------------------RVVFIDFSVYNANINLFCVLRLVVF-IVGCEVIFCVFIFYYV---VEEILELHIH--------------------RLRYLSS-----IWNILDLVIILLS---IVAVGFHIFRTLEVNRLMGKLLQ---------------QPNTYADFEFLAFWQT-----Q--YN-NMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCA-KDILGFAVMFFIVFFAYAQLGYLLFGT-Q---------------------------------VENFSTFIK---CIFTQFRIILGDFDY-------N--AID------------------------------------NA-NRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQK-DELQLSDLLKQ Homo_sapiens_TRPP4_A ------------------------FSFIIN---HGPQQCSNFRDKHVPLTYKIIVSDLHSVGEISSVKENT--------------------------------------------LGTSTVPP--------SFLPVGMLASQYGLSLLSTLIQK------K---DF---LPAGYLL--YIVASVLNNMK--TELPLRDDR-KRRALLFLSYILTHFIFLALLLILAEI-YLYVAILIFFLAYV---VDEGCIIMQE-------------------R-ASYVRS-----VYNLLNFALKCIF---TVLIVLFLRK-HFLA-T--GI-IRFYLS----------NPEDFIPFHAVSQVD-----HI--MR-IILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAA-LPGICHMAFVVSVYFFVYMAFGYLVFGQH----------------------------------EWNYSNLIH---STQTVFSYCVSAFQNTE-FS--------------------------------------------N--NRILGVLFLSSFMLVMICVLINLFQAVILSAYEEMKQPVYEE--PSD-EVEA--- Homo_sapiens_TRPP5_A --------------YR--KE-VEITTTLQE-LL----LYFIF-LINLCI-LTFGMVNPHMYYLN------------------------KVMSSLFLDTSVPG--------EER-----------------------------T----------------------------------------------------------RVIFIDFSLYNANVNLFCIIRLVAF-IASCEITFCIFLFVFT---TQEVKKIKEF--------------------KSAYFKS-----IWNWLELLLLLLC---FVAVSFNTYYNVQIFLLLGQLLK---------------STEKYSDFYFLACWHI-----Y--YN-NIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCV-KDIVGFAIMFFIIFFAYAQLGFLVFGS-Q---------------------------------VDDFSTFQN---SIFAQFRIVLGDFNF-------A--GIQ------------------------------------QA-NPILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKADYSIGRRPDFELGKMIKQ Homo_sapiens_TRPV1_A -DPETGKTCLLKAMLNLHDGQNTTIPLLLE-IA----KELVN-ASYTDS-YYKGQTALHIAIERRNM---------------------ALVTLLVENGADVQA--------AA--HGDPGFYF--------GELPLSLAACTNQLGIVKFLLQN------SWQTAD---ISARDSV------------------GNTVLHA---KRIFYFNFLVYCLYMIIFTMAFR-VTGEILSVLGGVYFF---FRGIQYFL-QRRP------------S----MKT----LFVDSYSEMLFFLQSLFM---LATVVLYFSHL--------------------------------------------------KEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGP---A-----C----RPPDSSYNSLYS---TCLELFKFTIGMG---DL--EFT--ENY-------------------------------------D-FKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNI--WKLQRAITILD Homo_sapiens_TRPV2_C -EGSTGKTCLMKAVLNLKDGVNACILPLLQ-ID----QPLVN-AQCTDD-YYRGHSALHIAIEKRSL---------------------QCVKLLVENGANVHA--------RA--CGRTCFYF--------GELPLSLAACTKQWDVVSYLLEN------PHQPAS---LQATDSQ------------------GNTVLHA---P-KFFLNFLCNLIYMFIFTAVML-LTGHILILLGGIYLL---VGQLWYFW-RRHV------------F----IWI----SFIDSYFEILFLFQALLT---VVSQVLCFLAI--------------------------------------------------EWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQP---M-----EGQEDEGNGAQYRGILE---ASLELFKFTIGMG---EL--AFQ--EQL-------------------------------------H-FRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSI--WKLQKAISVLE Homo_sapiens_TRPV3_A -ASDTGKTCLMKALLNINPNTKEIVRILLA-FA----GRFIN-AEYTEE-AYEGQTALNIAIERRQG---------------------DIAALLIAAGADVNA--------HA--KGAEGFYF--------GETPLALAACTNQPEIVQLLMGH------E--QTD---ITSRDSR------------------GNNILHA---KHMFFLSFCFYFFYNITLTLVLQ-LLGRMFVLIWAMCIS---VKEGIAIFLLRPS------------D----LQS----ILSDAWFHFVFFIQAVLV---ILSVFLYLFAY--------------------------------------------------KEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDN----------------------------KDCSSYGSFSD---AVLELFKLTIGLG---DL--NIQ--QNS-------------------------------------K-YPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERI--WRLQRARTILE Homo_sapiens_TRPV4_C -EPSTGKTCLPKALLNLSNGRNDTIPVLLD-IA----REFIN-SPFRDI-YYRGQTALHIAIERRCK---------------------HYVELLVAQGADVHA--------QA--RGRGYFYF--------GELPLSLAACTNQPHIVNYLTEN------PHKKAD---MRRQDSR------------------GNTVLHA---AVSFYINVVSYLCAMVIFTLTLR-LAGEVITLFTGVLFF---FTNIKDLFMKKCP------------G----VNS----LFIDGSFQLLYFIYSVLV---IVSAALYLAGI--------------------------------------------------EAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQT-NCTVP---T-----Y-PSC-RDSETFSTF------LLDLFKLTIGMG---DL--EML--SST-------------------------------------K-YPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHI--WKLQWATTILD Homo_sapiens_TRPV5_C -RGALGETALHIAALY--DN-LEAALVLME-AA----PELVF-EPTTCE-AFAGQTALHIAVVNQNV---------------------NLVRALLTRRASVSA--------RA--TGTNLIYF--------GEHPLSFAACVNSEEIVRLLIEH------G---AD---IRAQDSL------------------GNTVLHI------FCILAALYLLYMICFTTCIR-LVGELVSIVGAVIIL---LLEIPDIFRV-------------------GASRYFGKTILGGPFHVIIITYASLV---LVTMVMRLTNT--------------------------------------------------NGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDP---------------------------------TSLGQFYDYPMALFTTFEL-----FLTVI--DAPANYDV-------------------------------------D-LPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDEL--WRAQVVATTVM Homo_sapiens_TRPV6_A -RGAMGETALHIAALY--DN-LEAAMVLME-AA----PELVF-EPMTSE-LYEGQTALHIAVVNQNM---------------------NLVRALLARRASVSA--------RA--TGTNLIYF--------GEHPLSFAACVNSEEIVRLLIEH------G---AD---IRAQDSL------------------GNTVLHI------FCMLGAIYLLYIICFTMCIR-LVGELVTVIGAIIIL---LVEVPDIFRM-------------------GVTRFFGQTILGGPFHVLIITYAFMV---LVTMVMRLISA--------------------------------------------------SGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDP---------------------------------EELGHFYDYPMALFSTFEL-----FLTII--DGPANYNV-------------------------------------D-LPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDEL--WRAQIVATTVM Terebratalia_transversa_TRPC -VDPLGRSGLLISIES--EN-VEMIDLLLS-YG--VE---------------I-GDALLHAINEENV---------------------EAVELLMQYQVSK-K--------KN--LAGDSFTP--------DITPIILAAHRDNYEILKILLDR------G---DH---IPKPHDV--RCSCRECIADTNEDVLRHSRSR-RKPFIKFIIHSSSYFTFLLLLILAPP-TYIECLIMCWVAGLI---WSEVKQLWDV-------------------GAKEYIQD-----MWNLLDFATNMLY---ITTITLRVIAYIKVEEEK-RV-N---------------DPRA---YLRRSDWDAFDPNLI--AE-GLFSAANIFSSLKLIYIFTVNPHLGPLQISLGRMV-VDIVKFFFVFTLVLFSFACGLNQLYWYYAAERQ-----Q-ECQSRPSGD-----C--DN-KRYKALLNLWE---IAQTLYWGIYNMIDLEHF--TL--KEDH------------------------------------YV-TQLLGKFMYGTYSLIAVVVLLNMLIAMMSNSYEMIYNQADTE--WKFARSKLWMS ; END;