#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on July 09, 2025; 14:05 GMT TreeBASE (cc) 1994-2008 Study reference: Scheel B.M., & Hausdorf B. 2014. Dynamic evolution of mitochondrial ribosomal proteins in Holozoa. Molecular Phylogenetics and Evolution, 76: 67-74. TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S14909] BEGIN TAXA; TITLE Taxa; DIMENSIONS NTAX=25; TAXLABELS Acropora_digitifera Acyrthosiphon_pisum Amphimedon_queenslandica Anopheles_gambiae Caenorhabditis_elegans Capitella_teleta Capsaspora_owczarzaki Daphnia_pulex Drosophila_melanogaster Helobdella_robusta Homo_sapiens Hydra_magnipapillata Lottia_gigantea Mnemiopsis_leidyi Monosiga_brevicollis Mus_musculus Nematostella_vectensis Neurospora_crassa Saccharomyces_cerevisiae Salpingoeca_rosetta Schistosoma_mansoni Sphaeroforma_arctica Strongylocentrotus_purpuratus Tetraodon_nigroviridis Trichoplax_adhaerens ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M21616] TITLE S_Blocks; LINK TAXA = Taxa; DIMENSIONS NCHAR=17924; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y *" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 1810 1820 1830 1840 1850 1860 1870 1880 1890 1900 1910 1920 1930 1940 1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 2050 2060 2070 2080 2090 2100 2110 2120 2130 2140 2150 2160 2170 2180 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. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] Acropora_digitifera -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAAGSVRDLRLISGFRGNSIISSLIRPMKTMKPSCSKSTTKLTVPNHDQ-SADFPVHKEAIDQTDNDGVDIYTSDNI----------------------------------------------LRHPDFF--EVHKL-----------------------------------------------------------------------------------FTLKDLFNAKVHLGHHEGCWNPLMKPYLFGTREHQHIIDLNQTVKHLRLALNVLSHITYRAGIILFVSTHPQFEELTQYTARECGEYFVTRRWRGGTLTNPL------------MLTGM------------------------TRVPDLILFLH-LPSLGRN----TLAVKEAAQANVPSIGIVDSDCNPNLIMYPIPGNDDSPSAVELYCNLFKKAILNAK----------------EVRQ---------------------------------------LRRSADIPEEKIVNDDLENANLDELL---------------------------------------------------------------------------------------------MRVVPPALV---ILGVRHAYQPKSKQ-----------------------QKKDNIVPS--HRIG----------VTQSWDSQHTGSLKGSYWASE-RLLDDVMIRKFVQGV---MH-GFVQS--EVVIKRKANRIS-----LVF-------------------------LV--TKE------VDIVKFY------------------------------------------------------------------------------------------------------------------------------------------------FLQGFTEKLLT------------------------ELLGCVVKIEP----------------QTVY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAALRKF------------------------------WFNAVSCSLLTGQNCHLAHI-SFLKKDSWAATGIV---------------------------------------------------------STQIFQQRSYVPSDQDK-------------EYENLWAAVTGGR------GTGRGTKKKVVKG----VD---PKLLK---YVVLKN-----FHSVVIELRRVSNMTPG-GRKKTLRSMVVVGNKNGVAG--------------------------------------------------------------------------------------------------------------------------------YGLRCHRAIKEIAVLLGITDMRCK---VRGPT-TPLSLVRAAFQG-L--------------------------------LSQETHQELADR-----------------SGLNVVEFREECGM-RPVIVASP-----------------------------------------------------------------------------------------SVESQRKVSKKREKKEYDLNEVFDPYRG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LHRPKKRQELY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVLRRTALSIMDKGGVVRKM-E---NLGE-QELPH----RMRAHTEWH-THG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLQG--------TVIKKKIELHKRA-------------------------------------------------------------------------------------------------------------------------------------------------------------EDNRAFAHYRW--------------------------------QG-----------------------------TVIKKKI------------------------------ELHK---RAEDNRAFAHYRW----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGSDGASRTGSVSSESSQGQDEDDPV----MQDLIVKYE----RYR-----LWLAKI--------MGKDPENF------------------------------------------ADKEIKETIEYLMPSGLYAKDARPLFEDP------K---------------------------------RLY-KKKAEL------------------------------------------------------------VDK----------------------------NSRPLHAAF------------------------------------------------------------------------------------FTGQIGFHDLLFEIYEQNAILDNDENPETSKESEARKYGGYTPDESQGSNLASSKQWAIGIERDVYASSESESSSDAESSSDSDQESTNDSMPD---LGWEENSGKIPATDSLVTQDTKETESGKS-ATQPKMRWIGKLEMEK-KIGERLTDKEYDV---ITHRLKKLASHPNASRV-TPFLLQFLHV----IAIQGMRAVERKLND-----KGEAVAV---GHRKRAI---AEVV-MKKGSG---SVTVNNTPMAKYFGRVEDRKQIMYPFLTVGAVGEYDVDCG-----------------VIGGGTS---GQAGAIRLALSRALLNFEDS-YLEPL------------QEA-GLLIRDPRIKERKKPGQKRARKKFAWVRR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRPRFNLTT-EKFSQTLAFPPESYKKQSITYHLKKHGRMIEIGEVPVEKSDIYIQYLQENTPVGVSVKMELALYN---------------------------------------------------------------------------LKALAFCHVSC-------------------------------------------------------------------------------------------------------------------MATLRATMC---------------------------------------------------------------HFRLLSQDLLC------HRSLTWCVL---------------------------------------------QGLSRRCKKAL--------------------------------------------------------------HPIPTKRFVGSYLQIKEH----------YKRSAAQAAKYKNLP------------------IIQIN--ASFNNTVITLSDPKG-KTLGWVSAGTEGFKNARRGSSTAGRQAGIAAAYK-ALSLGVE----SARI--KVCGIGTGRQGAINGIEAAG-----VRVVSVTDVTPVPHN-GCRPRKARRL-----------------------------------------------------------------------GARFL------------PTLNQYRRGK-AKTKAEI------------------------------------PEKYIPKNKRILLG---PQRKGVCVKVFTRKPKKPNSGNRKCALLKLS---NGKTITAYIPGEKAVLQEHGVVLFEGGRVQDCPGIKYKIIRGKYDM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQGILGQKVSTKSY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATISYAPEEVKRVFSL-QNANQVEHRKIAIEKVREKFTDR--------------------------------AERQIAELSVKIEA--VKKNNCTGT--NEKKDMHNKVFLNWLISQRKKKLGHLKNARFER--YLTLSKDLGIPLLESPH--------AKWNKYKFRKFKIGVEVKEKKRFRR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKKSLVTLRFALYGCK--NRPFFYIVAT----NRY---KPRN-RGYLEQVGTFDPMPN-------TRNE---KLVSLNMDRIR--------YWLS-VGARPSRPVAILLGLAGVLPPHP----------------------------------RSLVIATKNRATLAASAA------------------------------------------AQTSLTEESWKEELEQNPEGNESNEDQKDE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDKT----AKVLVTRMVLYRKLR-KYFNERKVYFAHDETNECTRGDLVIIKECR-KLS--KN-KAFTVSEIVERAPKVI-----------------------------------------------DPETG----LVHIQDN---------------RE----------------------------------------------------------------------------QNVRLLS--------------------------------QFISPHTGRIYGRTLTGQCCCTGHVS*NNVMTH*NN--------------------------------------------------------------------------------------PLSHFVGL--------------------------------------CNKKQTE----------ISGAI-------RRARAMG---IRK--------YSTLSSTSLLYFTLTIW-----------ACLCLFL-----------------VGFMPVTMKYLAFHDD-------PKLF--------------------------------------------------------------------------------------------------------------------------------------------------QISNMAHNRFLARTVFVGEG-------------------------S--------VNQALRALQRVLTDDK-----------------------------IIKDVQL--------------------------------------------------------KRNYEK-------------PTV--------------------------KRRRLKYE--------------------------SSLKLYNSEMKKKVE--FLMSKQRKVNP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WT------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPPVMEE---R-QEIDEVLEQNDELACY--S--ESRY--VFTDISTSVCDRSRSVTIREPD-GKLRKATWEERDRMNLIYFPKTGRRHEMPELLK-DENLKI----------------------------------------------------------IKKFDLLRSTRHFGGLVYYLAKAQRIME-LLEDMMA-KELLDDCLEVVKLHHLVN----------------------------------------------PHSSIADQSARNNLKGFSLLRSKVSIF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MP--SGRF-PFRRTYE-FLS----AGNL--VL-----KSSVKTVLL--NY-----THRKNSLGLRNFIF---------------------------------KDVPQIQFKNRTVQ--IMTLRNQSDIPLINVFLGDGRKITIDVESKTGPEI--LGLFGKVAGATDLERKDRAMPKYPGRFNP-ANFG--KYGHCYCICEKPGQFP--------------------CP-----------SRVP---HPEAKKPKF-------WQQKSEATG----------MDELSTRNQI-------------------------------------------------------------IVMLKKKSLV---YCREVKKEVKSLLHSERETKRELANQ-------------------MLWARQHQERVQHVK-----------------------------------------------------------------------------------NAIEESKNWVTKENLEEKIAYCLEHETNYNFALTSTGEKV----------FSDST---------PGSVDTEENGPGPSAYVSRVSRTQSQYNFR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFRKSDFVKL--GRPLGKLVAGKITHIVEQEDAIDLYVDFGWKFHAVVTEAKD----RKSM-YKVDDLVKIKLRTLEDTGHFLGQNKRVTLCEADAQLEGILYPDTTHSIFLKEQSLGAMANSEVNRFSPK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAMGIIKKHILPSNVRFFRFNALTRRHLCLLAVKEE---------------NEPHQ--TGV---------------------------------------PLIIAPHVIKR-------------------------------AFIVHPSTKVIDSSAKYQWFTKTKL--YEGLPASFPDLSSFFSDE----------EYEVVREQFA-----TSVLQNYAFRKETFNV------RKNERRGEQLRMGV--LQDLMRCLWPFS--DRYPHLNDCFVDLQPNIKIHWVR--QHNF----------------------------------YQLEYKPAYIIRSKEQAQLF------ELDVERTSSES---------LPGP----------FDNYSLGV------------YRHPI---VHLRNNPGFQ---N---SGLNKYPHNHMIFLTN--------------TYNLTYEQQ--------TAFGIMSMFSTLLALAMDRGFKLGEHLKEPLVTKCLVTDGIQFTSMCYQLNTL-SFQEDIGI-------KNCAWVSPNMNLFSKQEKTSARAWSILYESL-EKGEQ---V-SGFNDMCFKTILALFCHH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKDL-VLDDHARKKMISLVG--------------------PR--------YNADTDELTIVADRCPTRKQNKDYAMYLLTVLYHEAWVS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Acyrthosiphon_pisum ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATHYCRKIFGKNLTHNLKTRICPSYLSTLPKSQLDVAQDEQFLPDESKFK--------------------------------------------------------------LSNPDAF--DVKSM-----------------------------------------------------------------------------------VRIKSLFEAGVHFGHTEGTLDNRMKQYLYGNRLGHLIIDLNHTKRLLQQALNVTAHISYRGGVILFLCQSPLNCLTVENCAKECGEFAHTRYWRDGMFTNSS------------RIFKSE-----------------------TRLPDLCIVLNTLSSTSKNNSGQHSVLSDAAKMLIPTIAIVDTDANPNIVTYPIPGNDDTPSAINLYCDLFKNVILRAK----------------KVRK-------------------------------------------------------EILDKNKISV-------------------------------------------------------------------------------------------MMFLDTLPRFL---PARSNYLILSRCKHVQAARYKRSIK--------GNKPLTYEMAGPP--HTIA----------HIKGWNSWNTCNMLDGLRPAE-TAIDDEFIRRFMTGT---WH-DLIAS--EIIIKRQHNIIR-----IAA-------------------------IT--VQK------ISVTKVY------------------------------------------------------------------------------------------------------------------------------------------------FLIGYTEELLS------------------------YWLQCPIKLEL----------------QTVED-RTAVVFKYI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMSMLKRLLSPKSINIAQSVVSIKRPDILKDCTRCYRSLIAPQTRVVQFQSVCVQQVRNESFFKKHTAEHI------------------------------WKSVTSVSNAGKKRGRGKGA-GKKRAKNLNRGQVI-----------------------------GVGVDNMIWPGLNAPII-----------KGRDLIKRTKLPPDPER--------QARLVKLRDSMGTFKMLR----LLPTERGWSGSKMPG----RSIGPPDPIN---EYNFDG-----FDTKVLEFKTVFCMKANAGRYRRISVVTVTGNKNGLAGFALGKAA-DS-RAALRRAKNRAGQKLMYIERYNNHTVYHDFFTQFCNTRIFVEKRPEG----------------------------------------------------------------------HGLICHRAIKTICEMIGIKDLYAK---VEGST-NLQNVVKAFFLG-L--------------------------------LKQKTHQQLADE-----------------TNYHLVEFRKENDY-LPVIVASP------KGPVQTDPKEAP------------------------------------------------------------------DFLQYVMDNKVRLRKKKSLPFYTKKTHWYIKEK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIEIVRNMDKAKYNLLAEYGEIRSFLTDKYPECRPVQKKSFSKQIDEDENQ-----------------------------------------------------------------------------------------------------------------------------------------------------------MPSYELCLLFK-VLPRPE----ITQCLKRTASKIFESGGFIRRI-D---NLGT-ADTPW----KISSHDAIH-KQASYFIVEFDVPSSAVDPFN-----NYLSRDIDIIKRTIF-KVPENIPQP--------------AC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLHEEL------------KPPAYRSEVKEMIAIGKRKREKEARKKVQFNT-GLDYMPFQR---------------------------------------------MALFAKYLRIGSTVKHGFQAFPQLTTAK----------YS------------------------------------------------------------------VYPPH---FAEPVYKKQELDKLY--------ESGEIENYK---------------------LIPFKAAKSNET-------------CSIFHDPMVAKFINYMLLKGQKKLAR--EVLEKTFEKIKKL----------------------------------------------------------------------------QLEK-----YNRETDPEKKASMII------------DPVVIL------KKAVANSKPLLKLTAVK--RGGSFYQV-PVPITDKESTFYAMRWFVQCGREK---D-KSISFADFMATELIKASNNDG-----------------------------KVVNKKL------------------------------DLHK---QCEANRAYAHYRWS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMALQRLFNNLATSKLNTPKLLSNFV-P---RCSYGLNNVGSDD-----------PDVEIIEKKIVEEKTSLAMRAYLQRATQY-NSF----MQQQTHEYN----VGK-----RHLANM--------MGVDPETF------------------------------------------TQSDIDVAIDYLFPSGLYDPKARPLMKPP------S---------------------------------EVFPSKKDAE------------------------------------------------------------FDE----------------------------SGRPFHVFF------------------------------------------------------------------------------------YTGKPNFYLILHNIATK------------------------LSE----------------------------------LNKFEDSLRKNNILPD---PD--------K-----------------K-LTSLGSQWLSKEDLEK-LTVEKLSDHEYKN---FVIAIERLLKHPCSYKY-GEFISDYQKPMI--STKAIIESAPVEYTK-----DGRAFVTVKDCPRKDAR---ADVTVYYPGTG---KLSINGKGI-EFFDDIQAREQILFPLLFTDMVDKVDIHAT-----------------VRGGGVS---GKAGAIRFGISWSLRSFVDPETVERM------------RIA-GLLQKDYRRRERKKPGQARARRKFTWKKR---------------------------------------------------------------------------------MTTFLKTLLLNSRKSSALWP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYFNLSTRSFCAKPLRSEESNIHQNDLASVTPQNEELD--------------------------------------------KLY------------KTIEFECRSNDRAVLRSYTQFATMAANELGIQIGKCWSPRKAHHERYTLLRSIHVHKRCRVQYEVRTWFRFIHFHKLTGSTAETFLEYVQRNLPEGVALKVTKVLLE------------------------------------------------------------------------------NIPESVSSH------------------------MTSEIA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFPDIN-----------TPNMLFGGVKFSDVP------------------ICHIK--SSRNNTLLHVIKVNG-ERIMIRSCGMEGFKNTRKGTNIASQATSIWF--------GYK----SIRFWNSYSSCNNSRIRTRENV--------------LNKRSYYGWS---------------------------------------------------------------MNVLLQGMKNLVLNKSLGETTRCM------------ASLYQMHRTG-PHKKPMF------------------------------------KRNPLGDN---------PFLKGVILKTLIRKPKKPNSANRKCVLVRLS---NGKEMIAYIPGEGHNLQEHNVVLVRNGRCKDLPGVKITCVRGKFDLPHVVKKTQTNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFIINAFQRCKALAKFQTPVNDTCLGV---------------LPCYQQTRNK-------------------WPDF---RMKKDARKRNTLKEYGVYKLRYNALRKNDIIPLEIQ-----------EIADKEIYN-CPRDASITRIVQRCQVTSRP--RGNVKRWRLSRIVFRHLADYNKLAGVQ-R-----AMW-----------------------------------------------------------------------------------------MFSTLRSLIHPGNGVILSVR---------------------------------GLKSDLHIKWVRPEKI--------------------------------------------------------------------------ACWDPKKSGDLSPLKPLD-------MSKPPLEYQD-SEELKTANEYVRKVFSC-DFMGRRYATQLARQQLIDKVKAN--------------------------NLDFTSCEVQIASMTANIRN---LQEHYKLS----PRDKNSRVALKEIIDKRKKRLKHLRTWDYKK--FEWLLENLDLMYHPHPPYERVE---RKKSLRRLTSKWCDEVKSKKLAEYRTELDNEKEKFLKQKLETLEWAKKEEVECGVEPTITDADIENARKQLEEWKTLKSIQE-------------------------------------------------------------------------------------------------------MRAYRLLKKLMPSSGGGDDFEKAKKSIRLARYGCT--NRPFYHIVVV----LQR---RDCR-AHPIEQLGTYDPMEN-------HNGE---KLVSFNLERIK--------YWMA-KKARVTNPVAELLGLSGFLPIHP----------------------------------HTYMTAWRNRQKIKTESE------------------------------------------------------QSETATN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSLAGATKSLLLLGRCAPS--VKQNA----SKIIVKKLELDQNLL-MYFHKDEVYYAHDPEQQCKTGDVVLIQELSEKLT--TH-ITHQVLKVVYPLGDVT-----------------------------------------------DPITN----KKVAALRSGTVCYRDDLEEIDNLYGLTKKRFNYANAPKRGWQEDKKDFSHKKSYIKYHESEEEQPYSVPR--------------------------MFIYSGISIGVSTRYMG--------------------------RFRTNRFNPWTNLQKTIGQKKTEAIDGDVQAF----------------------------------------------------------------------------------------------------------------------------------------KSEHLVN----------IPNPY-----EKEKRLCIL---CKM---NIVPDY---KNTRMLSQFISRF--TGRIYGRHITGLCRHKQD----HVEKEIKKSREAGLMPFYFRNPEFSHD-------PKLFDPDNPFRPHHY-------------------------------------------------------------------------------------------------------------------------------------------MKHLKFISRTVLVRNE-------------------------N--------VDEACRVLNRIMGSEG-----------------------------FLDQYRR--------------------------------------------------------TMFYEK-------------PTQ--------------------------MRRRINYE--------------------------KCKAIYDEDMKRKIN--FVLRKNRP-EP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPGCY---------------MTLRNLFTSFYRLQNGYKHKCRGLNNITVYSFSSQSHD--------REI------TKELSNKFFAEPVQNLLFK-LTHVDV-QKAFRKR--------------FIGENPDTP-----------IYKFMTTAEVEKMQ-AEVKLKAKEKVQMPPIVPL---R-TDLGQVLEVNKDIIGF--D--SSKF--VFTDITFGVSDKRRIVVVREPD-GTLRKANEDERHAVNQIYFPQSGRELKHPVMFD-DTNLKPLL--ENGDYEFILDRACCQFEPDDKNYHRVVFSTYKH-VDE-----------------SKNYHILESTRHLGPLLFYLAFNKKPDN-FLLYCLQ-TERFDDIILFIQLYTKLN-------------------------------------------------QGLESEMDDSKDQFKLIEDFINTE-CIDKVNLEAALKDYTTRNSEIASKTN------------------------------------------------------------MAGSRLEKLGTIFTRVNGLIKSGA---MKIDDRPIWYDVYRAFPP------ESEPHYAKPSQSI-------------------------------------KIPDIYYPEDVFRAKFHKETRGQL--------------PAINLQETQQNQ--NATSLAVNM----------VVADPSLSVNQVID---TLKKNNVLQVYKTTSK-----------------RVEPTTINDSTNKSDFNETNVHTKETNVHSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPFMKGAA-PIRRTIQ-YLE----AGKI--VF-----KDRIKIVSI--HYN----TLGENHRGTRDFVF---------------------------------WHLPQIQYKNPDVQ--VMTLKNMTPTPFIRCFMSDGKDLLIDVDNRDKDRI--HDHVLQVLGKPKETL-HMEAMAKEKKDNI-ANFG--YMCEKHCMCEIFGQVP--------------------CP-----------AVVP---LPKSWRGKY-------KNEES--------------MQNLCKVELLYGKLLCKTKAINQQPVRYT-----------RKPRW-----LPKAPTKMFRVPVRPQISPDENKELFRLYTN---YRTTMK-SI----QEQLEYELETSYTGQEVLQEIANKEEVLWAKCMDVNDNWNAEVATEREQRLA---------------------------------------------KEREDRREEILAQLIEKEEDKKKKLEAVEEIIRLEKEKSKTYITVENIDEAIEKALDNVVDHKYALDLAGNIF----------KGNDP---------------NEPTTGTMSFQTLGVQSIN----------------------------------------MFALKKSLTTLAGRRLRGT---RAFLTEAYRCEDVWQERLDCSLLKKVQPE-VLYHKLSTALEQGSKQISAVDLDVFANSLTDHT--YLEELEELAHKFRLSAQTGTLLPSTHHAVVRLFVASNSTNDLIRILKDRLNYGIFPDYYLCNLLMDRFIKENDVLNAAVIASNQMLQEEL-DN----DITKAMGLYSCLKFITNPTEWEKAKVVT-EQTNDDDDDEEDRRVRVDFLRNPYFDDHFDLADGDHLVGKTMLAISRKIDSSI---LGNSFKTLGLAYYNRWNDLNAHLKKLDG---S-----VYLETIELAVTAID--------------------------KRAPENAE-----------QLKDTLAKL----QIENKSLTE-ESKNFVNEAV---SKNEEKEIQTQKAIYKEWESFRREELSRYLEHLNKLKRLQKVQQAKQDLKEKEQLLFFFDNEHKHD----L-VKEE---KLKRMKKTVVKDKSL------KD-DLTYVPPEIRKPG----FRRD---MASACRIFCRNINNTPLSKIITTKLRVSTK--------------------------KFIRPYSEQQDKLATLKHGAFAE---------------FYEKTKENKLVVEED------------QDFEMLLRNSNFINL--GDPEGKQVIGTIFHIVDN----DLYIDFGWKFHCVCTRPIK----NADS-FVRGSQVKLRIKSLELATRFLGSEKDLTLLEADAALLSLHKPIKY--------------------------------------------------------------------------MRAYRRLCG---------------------------------------------YATAAVKQETQYQI----------------------------------PTAARTEKKNPVDH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D--------------------------SQDVSKFYTI---------DPKTVSNIFQTGGLPK------------------------------------------PFTEQTNMFAETALMIRQPALEVINSL---KSTDFQ----------------KPAVRYLLYGQTGSGKSLSLAHILHYAY-SSKFILYHIPYVPIWLKYDRK--EVNWSSSKNGM---------ADIPLIAAQW---------LKHFVHQNGAL-LNELNLTTSQDYVWSQRE-TTPQGTT---LNELVTHGINRAKY--------AC------DCMDILLNELKAHCSN--N-------------RCKMLVAIDGFNAFFNEK-TDLKTEDR--VKVTPQQITMVQTGLSAVLSD--WNN-GAIIMVTSPRAALNTK----RES----------------------HLPIYLI---------GR-------QGFEHIDPF--IP---------------VMVPEL-------STVEFNNMLDYYEE-----------KRWLQKP-----GG-RKELEFL-TS--KLPADLMARCAPL---------------------MLTVRIPKRNVPNVFGRSLSSAY---VCRQE------------SRAQY--PPI--VD---IKPEPTLLRQELSD---------H-------EKIRNLSTVEEKSIGI-NMPR-----------------YYGWQSLVVKDKVIPYDFLPFAQTVTKTKIYEVDTLP-------NRLSNDDCQQ------FIDRIKPQLE-----DSLVFEYNRNRSRGKAIKSDKNIDESGSTNEFAKSI--AEQVNRIFLANLS-ADYPHLFEAQIDYEPRVEGFWNV-HGFAA--------TKEDEEIRKKKN-VPKENLKNPIDRWIHYFGRPTIQVRHHLPLPSVPLDKWTLTTAQSATSDIPKTAFKEFSIPNYD---------YDPSIYHK------------LPYER---RHGISIPGFW---P---NDQQKFGLLSIH--TN------EYL-----EDRPPNFGESEHQEA-VHAQAILASFAWLIGQASYQGFTICNELTYPLVNQSIITNGKTWSFYMYQLNTM-RFFKSQDDINRPIAPSNICWGTKQTELF---------------HNI-TDDRI---V--GWNDDVLKDLLSCYVNIPK-SRDH-EMCPYLGKE-QLVANIDDIKKRVWLHDRYKVLTSH---------------RPRHRLLPEVYDWERIYKIEHETRHFEARRRFFELEQDPLNERRLDDHYGPYIQRKDRDKGRRIRKKRFDDMYYPNV--------------------------------------------------------------------MNPTLSIKCIPYINSSKRNGIRGVYCLTQRFKSDDDNSSKKNQLAIDKLNNLLKTMKKGNDVEMPPHESKPIELAKPRQLARKSEQNK-------------------QNIDDSKQNKPLGEKLSDAATEVAQSIGGDTNKTKSDLLNLLRIYNNEPNDSSEKKVKSS-----------VQLDDLLSGMKIDRSQSKK---------------------SVEFSAVDRAQRIRELLGHSSGDHQRTKKYRKPMDNYMPINLFSSEPLGIFKNFDTKKDFPT----LPTWDRLHEKSLQTAVT-----HPPKNIYEQMIIWTEQGKLWKFPINNEQGMDDENNVF----------FAEHVF-LEPLIDEW-C---------------PKKGPIRH-FMELVCVGLSKNPFLSVEEKKDHLNW-FRQYFYEK-NQLLSEVGAFEIKSLPENVKEYYKPTIPDE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRFYKYCDLVNANTNYANRMKML-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNRIFGDVVRP---------------------TNEKSMRVVKMFSEEPLYKKENVI-NYYPRHIE-TGLLMKKLREYGLFRDEHQD------------------FIEEMRRLKALRGK-VFV-----------KGEKKRKAKSIL------------------------MSVKLIGRT----TNLYG-----------------------------------KTLWEILGNLRTTGVGRLVTRNSYD------------RY--EEPSFFRVLSVEPTAQIED---------------------------------------------------------------------------KARKIIVHAEKIFRGKHYKEPVEIYSVSYKPDYRLIPKDEEQLWWDRLAN-CKPREKFVPGSIELPPLMKLVLERDNKDSNIK---------------------------------------------------LQLKIRGGRDNVAKSDITKIASYGPSFFKNQQSS---------------------MSALQTTLRRTTAVLMPI----------------GYYPAR-----------------------VWCSTRAAPTDGKFR-----------------------------------------------------------------------VLDLKKKSFVPHAKKKYIKTITLPP------------------------------------------------RALSM--------------------------------------------------------------PVDQEWSNV---------------------------------------------------------WPGPR----------------TFHPATV---------------------PLA---LRQG----------------------YDPKRASPGK--------------------YGNAELMKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNFLHLTPPAVKKHCSALKQ---FCTEWPKGLETDEDCDRHF--PM-TTITTDYCHSSP-TIKDPKSRIVTIKIKLSTL-NLDKHARDKMIRLVG--------------------DR--------YDEESDILTIVTDRCPTRKQNYDYGVYVLTALYHESNTFEEWERQKQEADM-EHYI--------WENNPSKKAYVTLTRWPEKVSDDDV-------------KSHSIDEDTVGQKYKEAVTELLN------------------------N------GEDTYTLNKYREAALAVLLPQTIQA------------------------------MNTKMIVRFYQT-----------------------------VKPHQ-----PLIQ-------------------------F--RHGVPV---INKSESTPSPST------------------VGAVQTMED-----------------------------------YQLPTKFKRVMMDDAEINAINS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------G---------------------------------G-AE--------------------------- Amphimedon_queenslandica -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFLRALLKSSPALRLCRFCTNTVAKVDISFE-ENSNTA-------------------------------------------------------------------SDIYDKF--NINEI-----------------------------------------------------------------------------------VTVRKLFEARMHLGHKHGVSNQLMKDYIWGLREKIQIFDLDITSEHLKRALLVAGLIAEKKGVILFVNSRSQFDRLIRDTATDCGEYYLSPTWRPGTFTNSQ------------VMLKT------------------------CRLPDLVVLLNWHTN--------VQAIRESIMCNIPTVCLTDSDSDPRLVTYAVPGNDDTPSSVKFFCEAFRDVIRNAK----------------SNVD---------------------------------------------------------------SE----------------------------------------------------------------------------MAAVSLGRSVFLVRHVGVSSSPWTIM---RTRKIHTASFM-----------------------LQPGNKERRKKA--YTLG----------VTHSWP------SRGSIQKDQTPLLQDLYIRKLIMGT---FP-GVD----EVIIQKKANNIT-----VTF-------------------------WINLTAY-----RSQAPSLY------------------------------------------------------------------------------------------------------------------------------------------------FLSAYTETILS------------------------HWLAVNVSVIV-----------------KGYF-KKAT---FI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MANLLQLFRSFTSRLHLQLPPQQITKRFYASRNPLERRTAKEL------------------------------YDALTG--GKGGRKGRGQKW-DRVEWVQLPRKIPL-----------------------------GRGRTGKRWPGLSYPLPPAKESTGPLLDSQKKLLAPVELSEQTEQ----EGLDDLGIISISDLKGEYRSKRSLHEMNWSKKGWSGRTWKG----RYVGIPEAAN---GTPMPD-----FHSVILDMYR-ARWKCSMGSQFAIQTSVIVGNGKGMVGFGVARSK-DM-RGCIRRAKNRAVKQLRCIPICEGHTIFHNIKSKCVRTRVLMERKEKG----------------------------------------------------------------------FGLRCNPKLQAVMQLIGIKDIRIK---QLGSN-HVGHLVRATLSG-L--------------------------------LGQETYESLANK-----------------TGEFVVQYRTEYSG-RPLVVGVP------------------------------------------------------------------------------------------------------SSTDESFLIWLRDHQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLHSDLEQKLFKNKQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVRYEIAIILK-SLPRDQ----LKNAFRTAATTILNEGALLRQI-Q---YLGH-RKLPY----RMVAHKAPF-DEGSYLVCNIEAGPHMVKTIM-----DTLKKTKTVIRASMV-KI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAIPSLLKQR----------IK--MFSSIMTINP------------------------------------------------------RYFCT---ETDPSLPSSIFVTPSQVP---------------------------------------LAAPSYLT-------------PSFLDDPIVTKFLNVMMRDGKRSKVQ--TIFKKTLEYIKIH----------------------------------------------------------------------------QTKE----------LKSSNSKVET------------DPLVIF------HEALKNITPLVGTTGVR--KGGKVYQV-PVPINDKRRQFLGMKWLIKAAERV--KS-SHKTTPERLGAEILQAYNNEG-----------------------------AAIKKKQ------------------------------DLHR---LAEANRAFAHFRW-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLPVLKRSIKSCREISSLLGAKFPSVSRFTTTE--------------AEPP-----------PNEELEAPPINAQPIVLEKTSPTEEELKNEEPW----MQEEIIAYY----RSK-----NILAKM--------MGRDPETF------------------------------------------SQEDVQKAIRYLLPSSLFDKKARPFLKHP------S---------------------------------EIYPKRI----------------------------------------------------------------------------------------------ESVPSQPL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KWIEKDKLQN-KIEEELTDEQYQD---IINKLKPLAAHPDSHLI-SDFLDQYCKP----VLDYRAKAKKYAISK-----CGYAHAM---GHRKTAV---AEVW-LKKGTG---EVTINNKPLQKYFGYITHRQQALYPLVLTKLLGQFDVKAR-----------------VHGGGES---GRAGAIRLGISRALLAFPGD--HGEL------------LEAENLLVRDPRRVERKKPGQKKARKKFAWVKR-----------------------------------------------------------------------------MFKLFSQSFRAVSLPHLTLRAVS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPFCSATKAITDTKSTPPARICLPVEDESGEELVP---E--------------------------------------------RLY------------SMINIKVQGFEFAVLESYIKFVTTACEALGIKNGGRVALPT-EFQKFTVLKSAHIFKKHRVQYEIRTYSRLVQIRQITGTTADVFLEYIQRNLPEGVTMTIYQYEVE-------------------------------------------------------------------------------KPPQVRSKKKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MT----------------------------------------------------------------------------------------------------------------------LPCPSFLFKTVRF---------------FSKHSIGITTLNHLP------------------IIHVN--ATFNNTIVTVTDSDG-KTVAWSSGGLEGYRNARKGTTFAAQSAGLTAAKK-ALDFGFS----TVRV--RVKGVGPGRQSAVKGIEVAG-----VSIAMLQDVTPVPHN-GCRAKKPRRL------------------------------MVKVSMVRNRAKVGVPIFNNYYKMAAYIKTFSQFFLRSFHSTPLFQ------------RTVNQLMRQG-PNARQSKKK----------------------------------PHRFLGNR---------PQIKGIVLETMTVRPRKPNSGERRCCRVRLS---NKKEAIAFIPKEGHTLQPTDVVLLEGANGRHLVSVKLRVVRGKYNCAHPVKKN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVKMELFTRFCSGSFAKLLPSCGGLLSQ--------------------SPWNNTVRSC--------------SGVAGNVTWLKKWGRRDMKRRRMVAEYADHRLRLRVIKKSNMLPVQVL-----------QKAKADLAA-LPKDSCMTRVRKRCTMTDRS--RGIVTQYKVCRHKFKQYADAGLIPGLK-R-----SMW------------------------------------------------------------------------------MSLKAAAFLSFGGVRLLLQRTVQLPSHSSLI-----------------------------CSRAASSKAAGTGISITSKY-------------------------------------------------------------------------------------------------------KFGYND-IPEMENSPEAVKKRFSI-EFASKKQRNKLLKNEMIQKYQQN--------------------------PGDTGSTAVQIAIMTAKIQN---LTEHMRNN----RKDKSSLRKLLHGIERRKKLFKYLRRTDFTR--YHVLLKEFGLKPLVDDKYATLDK--KNKK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPSCTGLKIRLALHGCT--NRPFFHIIVT----ESR---FKRN-GRHLEQLGSFDPMPN-------YNNE---KLASLNVKRIK--------YWLG-VGATPTNLVSKILGLAGLLPIHP----------------------------------RTYLETRRRREGLLQETA----------------------------------------------------VAESEEARLKEQS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSMFLGRVMKC--KANNT----VKVSVTRSYLHPLVL-KYTAKRRKFEVHDEKS-CNVGDLVLIKEMQQKI---QD-KAFRVSEIIERAETYT-----------------------------------------------DPETG----EIHYQPFM--------------------------------------------------------------------------------------------------------------------------------------MAALLCRVKRTSVSFSKNLKLLVNNRLYALSRS------------------------------------------------------------------------------------------------------------------------------------NTDAY------------ISNGV-----NDCPKSCL----CSN---GILIDY---KNVQLLSQFVSSQ--TGMMYPRTYTKICMKKQK----QLARAIKRSRTMGFMPYTYKIPEYLND-------PKLF--------------------------------------------------------------------------------------------------------------------------------------------------MAVRKAIQKVTNRIVIVDPN-------------------------VSSEYGTSPVDVAYKSLTKIMNDHN-----------------------------IITKVHR--------------------------------------------------------KRYHET-------------GTK--------------------------KTERMEYE--------------------------RAVRVYNREMKKKID--FVMKMHKP-LP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PI-----------------------------------MWAQMATRRLSFLFVRSYC-----------SE------GPQSSVRFDDERVQNYISL-LNGRDF-NKVFSLR----------------KGEASLP-----------KFKLMNREMVKKAY-FDTMKRCEERLKPPPVVEQ---R-KDLGEEISTDPKLKDF--D--DSKW--VFTDISMGIEDKDRYIVVREPS-GTLRQATAFERDRLCQTYMPAPGRKIWLPTLLT-KEELPYAL--KRVNVLHILDLVCAQCPPDSPDYIRVQETAYEY-VRS-----------------QGLYSELYSTKHYGGLIWYLVQKDKLLG-LIGFLVS-KEKLGDVEILVKLYCLVH-------------------------------------------------PDTATESIQELTGEEMVKSFCEHK---GYLTILDSLSKENDSSSEPVTATDTV-----------------------------------------------------------MGSRLFDFGTVLTRMKDLVRSGV---V--KKCPVWVDVVESHPP------LTPMAVNVAFQKG-------------------------------------KPKQIVYDKDVLMKDYFDQYRRHG--------------ETVSLFEDHKQP--TVAEKFVEHQMFLLGEKKLTKENKDKTSLETVE---HMKEQYRITLLKKDKD----------------YARKETTRRRQELEEKRQEEENLDNQENRS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAT------KYRRTLS-FLS----AGKI--HL-----KNSVKVVSI--FYN----LTDPSCIGVKAFMK---------------------------------EKVPQIQYKNPEIQ--IVSFKNTKTTPQVTVYHSNDTKTFIDCRYKKCEQI--LEELSITCAKPLSQV---EREAQLSLPNP-ANFGD-VRKGQYCICRIPGQIP--------------------CP-----------SITP---VRNVDHS---------WKNKRGA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATIRACGVMSRFGASLRTLTTPQTRYRDTKRPIV---------------------------------------------------------SFRSLSWSTEGENRTNGE------------ETFAEMMAKSRLLTSCGSSPVGHKVLGKIIAVVDD----NLYIDFGGKFHGVVPCPEF----GSEI-YVVGTKVEVIVKDLEMSAHFLGAPQDSSLLEARIKLVGLLREFKMNLISNSKTGNETFYEDDDDDLDASFYDDETTSIYDDNDEDDNRSITIFQ----------------------MAAIMQCRKIHRIFSPLINYSGPSN--------------------------------QPMTATNYCTATEPVVETT-----------------------------TPKFDIS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VDQLGTIYSV---------GYSDLKKYSLHNHLPT------------------------------------------TLKKKVEAVGKVSWLLRDPSWYVLYHL---KNKS--------------------GKRFLF--------------------------------LFKWTHSSRE--LKP-LLQTDGL---------YDLPDDTVDW---------LSQFKEMNHQH-IS--ELKLSQDYTWNNKE-TVKAGES---LLDIIKLGIAKPKV--------SH------NVFHTIFNEISVLNKY--LNTLCTTSPILVPYRQSVLLAVDDINGCYCP--TSF-------KQVEPEHLCIVKTLREFLQPN--------------------------KGR----------------------YL----------------------------LESF--DP---------------VKVMPF-------SAGEFNTYINNLNK-----------ENWMNKELNKLMED---ELWTL-SG--GVPGELEKICRYI---------------MAHHLRASCFLANRSSTLKTFSRCYGYVHVVHKTI---------------------PHL-------LGPGNVWRK-----------------------------------------------------------------CYVVHPCSVKKDSLLHAQWLTGTKL--VNGLP-------KEINSISLPNDF----IVTEFKERLI------------DYMKISPDT------TPLYSNNNNLNFGL--YQACLSCLWSL---GNFQHIQHSYWSPITKVTSYWRR-NGLNF------------------------------------VTFTKPSILYTSSALDLW------PTPSTTTLV-----------DPVKY---------LNPSHIQL------------FEQSF---DDINVFGGNK--------SLSLYPMAHTLIVDN------DYK-----KHTLEQ----------TISHALLQLFAQSSAQTVQNGYPLDRRLDYPLATQAILTDGLQYTFACYQLNTL-NMTETSQQEV-----FNYMWCGPTYKIW-------------------NKEKT------DLNNKCVTLLLKFLLNEPL----------------------------------------R---------------ETPALVCPVNDVKDTT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRRRHTPQSDDRRHASQSDDRRRHTSFSDD---------------------------------------------------RRRHALFSDDRRHTPLSDDRRRH----------------TPLSDDRRRSFAFRAPKPN----------------------------------------FKLPLTKPPPVVTDPVN---TSFTDGKRLGVFKIMTQEQSVRPPD----PWTFR-EDQLKKEISFINQYKPLMNEFEQLMK--DSPHVWKYPIDNQLP-SDEDNVG----------FEDHVF-LMKHIEDKDL---------------PRKGPVRH-FMELVATGLSMNPYYTAQEKVEHIGW-YKDYFKQFPRDELDLE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSATNYARRFARL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RARIFGEVVRT---------------------TNAKQYKVVSHFAEKPILKDLP---KWYPPIDK-FNTLLHRLRNLGLFRDEHLN------------------LAEKLREHRIARGK-VTPK----------KGQGKRKKKNK-----------------------MASLITETVLK----TLKESDP---------------------------------KKLFFHLYRLPHFGVGRRFVRVTWGDHTVKGKEEDGGKQ--NPPTFWTITRVQP-DG------------------------------------------------------------------------------ELKGGQVWGNLTWKGNLDPKERRILSHDLR-DWKLILLNEDEKKTNYNNP-------------------------------------------------------------------------------------------------------------------------------------------MAALRPPLLKDTLCFKWI---------------------------------------------NWSRRSYATGASTNRG----------------------------------------------------------------------PVRGFRKGTRTHNKKDDKKPRFFEP-----------------------------------------LISYNKMKPHKF--------------------------------------------------------------NEGVEWSSV---------------------------------------------------------CQTAR----------------PFDPYLI---------------------PLS---LRMG---------------------RPPKGEVPPPV--------------------EGNHELLKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNFFHLTPPAIEKHCVALKE---LCTDWPRELPRL---------PI-TVSSINKLSASS-DIRDESSRIVKLRFKVSDL-KLPERARTKLIKLAD--------------------HR--------YNKKNDIVTIIGDRCPIRKQNREYVEYIMKVLMIESMKEEEWEKKNEEP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Anopheles_gambiae -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TARVRSFVQRAANYSLKNSFPTQICCILLTKLVIKASHFIVVHKFQHKMLLRRIVAAG-KLNLPRSMATVTMPEQQLVAPEKGSDV----------------------------------------------LSHPDYF--GVHKL-----------------------------------------------------------------------------------FTVEDLFKARVHFGHKEGTLNDNMKGYLYGSRLGHCIIDLDKTVDYLRAALNVAAHIAYRDGIILFFNRNALNAHRVEQTAKECGEFAHTRYWRGGVFTNAK------------VQFGAV-----------------------TRLPDLCIFFNTMNNVLDM----HTAVRDAAKMNIPTIGIVDTNCNPNLITYPVPGNDDS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L---ARRCVHTTASVAKS-QSGRYKISPK--------GDRPLTYEMANPP--HQIA----------HRKAWNSWNTSNLEGELRPSQ-TMLEDDFIRRFMAGT---WH-GLVLS--EVIIKRQHNHVR-----IAA-------------------------II--SRS------IPARKMY------------------------------------------------------------------------------------------------------------------------------------------------FLIGYCEELLA------------------------YWLQCPVTLEL----------------QTTDD-RKDVIFKYI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPTVPTLCNVRETSFFNKLPADQI------------------------------WKGVISVSNAGKKRGRGKGS-GRITPKDLNKGQMI-----------------------------GYGKANIVWPGLSAPVI-----------RGRELVQQQKLPEDKER--------EAKLRRIRDEMVNFKRLK----LSPLERGWSGSKMPG----RSIGPPDAVG---EDEFIG-----FDTKCLELKAVVNMKGNHGRKRRVSAMAVTGNGNGLAGFGFGKAI-EG-RAALRQAKNRAGQKLMHFDLCNGHTVFHDFHCQFGATKLFVERKPEG----------------------------------------------------------------------YGLKCHRAIRTVCEVLGIKDLRAK---CEGST-NVQHVVKAFFIG-L--------------------------------LKQKDHQRIAEE-----------------KGLHVVEFRPENMN-FPKVVASP----TVCRTEQELENNEI-----------------------------------------------------------------LDFTQYCMDGKIQLQKKKFPPFYTKFRSWEIYLK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KQEYLRNQD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPTYELSVILR-QMSRPD----MVATLKRTATAIFDKGGIIRKL-D---NLGT-KPLPF----KTSAHGLVH-RTGSYFVFKFDTPPSAIDDLD-----EEYGRDVDIVRKRIY-RADVSQQEE-------------ITC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLHEEL------------LPPAYRKDVQKMIATAERNK---AKKVFQYNT-GLDYYPFQK-----------------------------------------------------------------------------------MS------------------------------------------------------------------QYGPH---FIEPIVNRDKIEELH--------KTGDLSKIS---------------------HVPVKAALSNQN-------------CSVFYDPLVAQFTNYVMKQGNKQLAR--DLVEKGFENIKRL----------------------------------------------------------------------------QLER-----YHLSESEEEKAKLEL------------NPRRLL------HQAVENCRPLLQLTPIK--RGGVRYQV-PVPITEKRSYFLAMKWLLEAIREK---E-RTVHFPEKMAWEILDAAANQG-----------------------------KVVKRKH------------------------------ELHR---QCEANRAYAHYRWS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVQKAKISKAMKAYLERAKEY-ESC----METARLEYK----LGK-----RHLANM--------MGADVETF------------------------------------------TQEDIDQAVQYLFPSGLYDPAARPTMKPP------E---------------------------------EFIPRKKGAE------------------------------------------------------------FDE----------------------------TGRPFHPLF------------------------------------------------------------------------------------YTGRPNFFQLLFDVVEN------------------------INK----------------------------------LNALEDSTRMKGKSLD---SV--------GKK-----------------IDTTGSEWLPKELLEK-KIVETISDIEYDN---FISAMNRLEAHPLSDRV-KDFVFEYRKPLI--SKLDNDTIPVPQHDE-----DGRQCVTIYECLRKTAR---GDVTLKFPGTG---KIEVNGQD-------------------------------------------------LRSVG----------------------------------------------------NTQQREQ---------------------------------------------------------------------------------------------------------------ITRSLAP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAPRPVRWYSDAVVASTSQAAVDQPPPVGVPD--------------------------------------------KLY------------SRVELQMKGIDPEVMKSYALYAKTAAEHLDIEVGKHWTLRKAVKDRLTLLKSVHIYKKHRVQYEVRNYYRFMHFHKLTGSTLDTFLEYIERNLPEGIALKVTKVELQ------------------------------------------------------------------------------ELPEHLRK--------------------------------------------------------------------------------------------------------------MSLLKQLNLLSGLVRRTLVGSVR------------------------------------------------------PLHQTATLRKV------EDRKAMLAS------------------------------------------LPSKDEGTVGERSI--------------------------------------------------------------DIDSMIDKKTSIFPDAN-----------TPTSLINGVPFNEIP------------------ICHIR--VSPNNTIISITDAKG-VPQFIRSCGIEGFKNTRKGTNIAAQATAISISTR-AIERGYK----TVRV--TVRGLGPGRMSAIKGLEMAG-----LNIVSITDTTPVSWN-PPRPRKQRKL---------------------------------------------------------------------------M------------ATLNQMHRTG-PHFKVRP------------------------------------PRQPLDGK---------PFAKGVVLKTLIKKPKKPNSANRKCVLVRLS---TGKELVAYIPGIGHNLQEHNIVLVRVGRCQDLPGVKIKCVRGKYDLPHVIKQK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSVVGFVSRFVTCGQNLA---------------------GYRLQQVRNK-------------------WADW---RMIKDHKRRQCVVQHADARLRVNSLRKNTILPVELR-----------EIASKEIEA-FPRDSSLVRVRERCAVTSRS--RGIVHRWRVSRIVWRHLADYNKLSGVQ-R-----AMW-------------------------------------------------------------------------------------------LAKLKTLTPSVNQIVRTY---------------------------------ALKSDLKIKWVRPEKI--------------------------------------------------------------------------PCYKPEKSGDLQSLPMFA-------GTELMKDYRD-SKELETANEHVRNLFTI-QHNRRREMVENFKEDMVRRVYRH--------------------------ELDYGSIEAQLGLMTARIRS---LQDYMEKF----PRQSVVKVQLKELIDKRKRFLRYLRRWDYRR--FEYMLEKLDLVYKPYPTHFHWIT--RKDSLRKLTNIHCDQIKETRLEEYRRQLESQQLDFLENKLKTLEFIRKEQTECQVPVTVTSDEIKAVRKQYEELKQKRAAAAESLKEPEDS-----------------------------------------------------------------------------------------------------MSLAAASGTGRFWARSAKTIRFVRQGCT--NRPFFHIVVM----ERR---KDQY-QPVIEQVGTYDPIPN-------EHNE---QLVSFNYERIR--------HWIG-SGAHISKPVAELLGIAGLLPVHP----------------------------------RTYMTAWRNRQMAEKLAQ-------------------------------------------------INAVKNSDNV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASRVAMLLGQVVPC--VKVNA----SKIRVRRMELDTNLN-MYFKKDEFYFAHDPDKRCKTGDIVLIKELPERLT--RL-ISHTVEEIVYPLGDIT-----------------------------------------------DPITG----KKVVVGK-----YREDIEEANRLFGKSKDAFDYANAPPRGRLEGTRDFTHGETYIKYHEDGKDQPFAV---------------------------------MMICGV-----------------------------------RSSLRSARAILGYVNTGALVAPTATRSAAPYKH--------------------------------------------------------------------------------------YTTSADN---------------------------------------NDSPVVL----------KDNPF-----AKERVQCVL---CKH---GIDPDY---KNVQLLSQFQSPY--TGRVYGRNITGLCKNRHE----QVEREIIKAQNAGFMPTYHKAVEFLND-------PKLFDPEKAIRPHKY-------------------------------------------------------------------------------------------------------------------------------------------MRHAKFIARTVLVQNN-------------------------N--------VEEACRVLNRILGKEE-----------------------------IFDQYRR--------------------------------------------------------TRYYEK-------------PFQ--------------------------TRRRINFE--------------------------RCKSIYNEDMNRKIQ--FVLRKNRI-EP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPGCN------------------MWKLFKDLRLIGGLARRSSTVPHTNPTLCRSLSSTAKSNSEPFLSY------EKDPAPAFLRDDVQQLLKS-ITRLEL-DKVFRKR----------------SVKDNTV-----------EYRFMTDEQLRREL-LHSIEQAQQMLQMPPVVQE---Q-QDSCRVISKDGALKSL--S--TSKF--VFTDITYGLKNSQRSIVVRHPD-GTLQEAPYEMRKRLNQIYFPLTGRSIHQPPMFE-DEHLQRLL--EEGKYEFVLDRACVQFEPYEKDYHHITAKVYQH-INE-----------------SRSFDALRSTRHFGPFVFFLAWHKLIDD-LLLDMIK-QDYLRNGIELIVLYSTLH-------------------------GMPIDEGVKQIALQTQMPSLFDAAEKSVDELKQDEQYLSIIEQFVNGQ-ATKKVQLNLAVQAYREMAAEKLRLAQGIRRMHGES---------------------------------------------------MANSRLEKIGTIITRTQGLLKSGA---MKFDERPLWYDVVTAFPP------HEEPRYDRPAPRV-------------------------------------PVRQIFYQEDTVRAKFHKSGKA----------------TFAVNLLDHNNR--TPTQQFIELYQSLS--TQ-GALDEEQVFATAI----DLHEDKMRQQRLDRRP------------------ADGAPQEQTK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPFMKGKA-PIRRTLQ-YLN----AGQL--ML-----KDKVKIFSV--NYN----TYGEHHEGARDFVF---------------------------------WNIPQIQYKNPKVQ--VVTFKNMTPSPFIRCYFENGKQMLIDIDSKNRQEI--LQHLTTVVGKSDETL-KAEAKLAEKQDNP-ANFG--IGCMKHCICEVPGQLP--------------------CP-----------GVVP---VPKHMRGKF-------KYQMK--------------MMANIAATLSGVFTKPRALALLQYTT----------VRFRRKPRW-----LGTAKSKLFRVPERKKQIEEEIEELKRLHNN---YRTQMK-AVRNFLRDEVEAYKLVSRAGLVLQTPEE--EEAEWQEALRRNEEWNRQTAAKREERLA---------------------------------------------AERSARKEYILERLLLKEQREMDKKEQIEAKVRIEKEQSKTFITRDNIDKAIELALVQPTSYNFALDREGNLH----------RSTDS--------SA------------------------------------------------------------------------------------------------------------------------------------ISAIDIDIYANKLVDES--HVEEVADLLYKFRLTEETSSTLDSTHHALVRNYLDHRCYGQLIEVLNNRIGYGVFLDEYSANLTLDQLLKGKEFRYAARVATLLALQEDF-SN----PITKALALYSCYRYAKAPDAEHFDD----LAPAEQGAGEAEIKVRVKFLRNEYFDDHFDLTDSQLLLGKTFVELGRAFGGAGSV-IGTSCELLGLTMYRKYEQACEFVK-------QNAGKELNEEALQMIRSTLE---------------------------KEPNKED-------EQLVAFTEVVDKLEASMKIGKDSFEK-LILEQVKQSV---GEHEKQQIEAQAKLYTEWCNLRQQRVDEELERMQRAKRLQEIEQLAVEMEKEEQKLWFFENEDKID----LQIDSK---RVFYPKRWFGKKKKP------RTVDVDYVPPEVRQRN-----------MALLLRLARQRTLCAALSQPARVGPYVKFS------------------------TEGVVSTDGQESSAEANKKVGGFAK------------AYQKHSDSLNPEQPNQPP------------KTFASLLRNSKLVDL--GDPEGKIVTGKIFHIVEN----DLYIDFGWKFHCVCTRPAK----NGED-YVRGARVRLRVKDLELSTRFLGSNKDLTLLEADCQLLGLISSPATRSQQARST------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVEFRTPEQTVANH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T--------------------------RATLGRYYTV---------PGDVRKKIFAHGGLPK------------------------------------------SFERQIKTFNECSLMVRRPAVEIMEYL---QRTDFA----------------RPVNRFVLHGEDGVGKSLVLAHLLHYGF-QQQYVLIHVPWVPNWMKRAKE--IAN-SASHEGS---------IDLPLDGAAW---------LVHFKSQNGPL-IKSLGLTVSREYVWTKRE-TTPAGAP---LMELVEHGINRAKF--------SC------DTIAALVEELKQHASA--G-------------RARAMVVIDGYNAFFQPH-TRLLTEAK--ARITPDQITLTKPFLSITRND--WTN-GVCVVTVDQMVKDAVAGP--AQV----------------------QEPSLALLE-------SR-------ECFEHLDPF--VP---------------VSVVGY-------DDAEYYSCIQYYLE-----------RKWIQ----TNEPGFEEELKLL-SC--QNPYQLMQLCASL------------------------------------------------------------------PEY--PPI--QD---LSFPAKKKRERESW---------H-------QKIAKLSSVEEKLFEI-NMPK-----------------YYGYKMNMLTDEKFPYNIKPFMQYATRTCF--QTGLP-------QYYDPLKEEAAK----ILESIQTELE-----DTIALELSNYSHVKRD-ETVS---PVEKEETVVRSL--LVQLNRTIANALA-PKFNHLNEIETDVDPRHEAFWFL-GGIYP--------PNLVRKIKEGVE-WQKQYANDPYDRNIQYVGKPYMALRHKLLLEPL------LPK-DLESFDVKQDGAE---IPDYR---------YDPLAL-G------------YIADF---RHATTVPGFW---P---GEQHEFGLLSFQ--RR------SHA-----LNRHKYCAVDDLSEA-IDAQGILSSFAWLLGQACYQGFSVFNDVTYPLTTQTVITDGKYWSFYAYQLNTT-LLHSDQV-DANSR--YNLCWGTDAMQLY---------------ESIDENGKI---N--GLNKEVLQQIIMFYINEPK-ERAV-NLKPYLCPTETRVADIEDENRRVFMERAYKHMASN---------------RPRHRLVPEVYQWEKIYKIDNKTRPMEPKRRPFELGE-NMYNRRMDEHALKYIPRAVRPGGPK-SRPKFEATYYP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FTEHVF-LEEQLEGW-C---------------PRKGPVRH-FMELVCVGLSKNHYITAQEKREHIEW-FRDYFEQK-KELLQDLIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSKYKELTKLTTTYARRMNYL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNRIFGEVARP---------------------TNSQSMKVVKMFSEEPVHKRDYVV-NWYPRHVE-THLLAMKLREYGLFRDEHQD------------------FKEEMKRLRALRGK-APPK----------KGEGKRAKK-------------------------RMATIKYIGRT----TDFRG-----------------------------------KTLWEIVGNLKNFGVGRIVVRSMFE------------RY--PEPSFMKIVKVEALPNEEP----------------------------------------------------------------------------ARKVRVTVEKTFRGQKSPNLVQIESVSYKADYRLLSKHEEPSYCKLVDR-AEK---IFPREIDLPPLLQEFI---ARETGKPAPK------------------------------------------------VPIKLKAGRESRYRVAQEGEQPTVEVAMNIG--KPASPSLYAGCE-----------RLQEDGARSGGLEEEEF-----------------------------------------------------------------------------------------------------------------------------------RVLNLKQTKSQRLARRKATRPEVPP-----------------------------------------------PRSQQM--------------------------------------------------------------ATDQDWGAV---------------------------------------------------------WPGPR----------------TFNPSAV---------------------PLP---IRQG--------------------YVTKRNQMSPGK--------------------FANAELMKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNFLHLTPPVIKRQCEALKQ---FCTPWPKGLETEEKMRAHY--PV-TCVTSDYCHALP-TIRNPLSRIVTVQVELGAL-QLDRHARDKLLRLVG--------------------ER--------YDPDTDLLTIVTDRCPLKKQNYDYAIYLLTALYHESNTVEPWEATKCEADM-EFFD--------YEQSRSKRNAEATLNWGRKEGDSGW--------------------QQVPEAYGKAVSRLFN------------------------E------GENEYNIAKYKEQTLALLGLAEAEQVAQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Caenorhabditis_elegans ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRRVVAAAIRTER-AFSTRFSASQQKPVASTSS-SSSVPDRATLEKGTVQPTVLKPFVSAS----------------------------------------------LQHEDLF--NFEKM-----------------------------------------------------------------------------------VHIDEMFKARLHYGHKVGTVNNNMKWALYGERLGVCLFDLDITKKYLVRALNFVAHVSLRGGMILFVTSNRDTMFDVEKAADEVGQYSHVRKWQSGTLTNTR------------QLLGAS-----------------------VRLPDAVCFLSTLTSLGEN----HPAIVEAAKMAIPTIGVVDSNSDPAYLTYLVPANDDTPQSTEYLLRMFKEAVRKGQ----------------EERK-----------------------------------------------------------RQQQGK-------------------------------------------------------------------------------------------MLRSIQHVEAL---SSRQISTTSMLLKN-RAGKTKSTSN--------RTQLLTYEMAQKP--HHIG----------VRKSWLTWHSQNLEEFRQSQPLVVAQDEVVRRFIRGF---FPQNLVVSGNEIVIKRRGNVLI-----VAG-------------------------FLQYSRR------LDIRRIY------------------------------------------------------------------------------------------------------------------------------------------------WMFGFAEEFLS------------------------ILLKQPVKLEM----------------AFVES-EEDVAYNYI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRRSGPEL------------------------------WKTLTSVSKSGQKKGR--RN-TRQPVRPLNRFYRI-----------------------------GSSPMKIEFAGLNAPIRMRET-------ENQNLMSIAEQTEDEIR------DSMGGTKKILEERDTGKKKRNREKLHPMERGFSGTQLVG----QKLGAPPPLD---GVNFDD-----FETYCLEVKRTSNMTNVFGRVHTMSALVVTGNGRGLAGYAVGKAPIHRTTTAIINGMGMASRKLFHVELHEGRTIYQDFYAECRNTRVFAQRRPRG----------------------------------------------------------------------FGLTCHPRLIKICEAIGIKDIYVK---VEGSTKNYLALTHAFVTG-L--------------------------------LNQETHQQLAER-----------------KGLHVVEMSPSRHF-LPQIVASP----ISTELKTEETLEAL---------------------------------------------------------------DRLNLDDFYGEGRYPLRKPKSLPFFSNLEGHLDARW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RKHPFRNQESTMIRLIADNMVPRWTRDARAAWADQRNERMTTGVEPMPLGIGLSHVVPKKDD------------------------------------------------------------------------------------------------------------------------------------------------MPFYEVSMITR-SLSKAD----LVKALTRAGNTLLDHGAVIEKV-E---SLGH-RDLPYK---RLAKQTNEPVYASNFFLFKAHMSREARQKTK-----SILTHDLDTVQVDLI-QVDTLPAPKVECNLEEILKSPAERQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVKDLR------------ENQKMGHFTRQMIYKRTEKEWKSIPKSYPIAPPRP--------------------------------------------------------------------MTTKLARFAQKR----------WI----SSTTSTSN------------------------------------------------------MYDPR--VFRDPVTNVQELRKPL--------DSDDERN-----------------------FLFLKAMKSDAT-------------PVFYRDHVIDKLIRVCTKDGEKETSR--KNVLSALEIIKRR----------------------------------------------------------------------------QYKA------WAKASEEEKKSIEL------------DPFLVA------KKGIKNCHPLMKLQGVT--RGGTTYQV-PFPIEEPEAEFRAMKMMRDICRVR-SKH-GETHFKDILATELLAASQNEG-----------------------------STIQAKQ------------------------------ELHK---TCEANRAYAHYRA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLRIVLARSSRAMSSASPA-S-------------------------------ASDSDTSVRKIGKALETYLKHSQQH-VAM----MEKHRAEFE----TGR-----RHLAKM--------MSLDIHEL------------------------------------------DQEAIDRAILYLFPSGLTDPNARPVMRPP------D---------------------------------EILPKFQRFT------------------------------------------------------------FDE----------------------------EGKPEGSRF------------------------------------------------------------------------------------FTLSPKIYGLLSDIGVK------------------------THS---------------------------------VMKFYDEHVGSRSVNRS---DL--------E-----------------P-ANLSGSQWVTADKLKK-KLSEKFSKELYGQ---VIIAFEHLASLPGSAIE-QKFLMEFREPMT--ASTGSKLFGPAIPEVHVCAVTNRRYAE-VTTRCKDTR---ATVKVTDAGKG---KFDIDGLQLHD-FRHLQAREILLAPMIVSQSLGRFDVTATTSCISNTLPEAPNKAPLMRSGGMS---ALPRAVRHGTALCVAALQPE-AIEPL------------RLS-GLLTLDPRKNERSKVNQPGARAKWIWKRR---------------------------------------------------------------------------------------MLKLASSLRTGLIS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSIRTLAPTVNPAEQQQVQAVLP---D--------------------------------------------KLY------------SSVEIEYRGHDKAVLKSYTSFLQQVCQHLEIPQGRLEVLPY-IRWVQPALRSKFVHKKYKLHYETRTHISKLEILNVTGSTASTFLEYIQRNIPEGVGMRVGFTELQ------------------------------------------------------------------------------PLPLTIQKN-------------------------------------------------------------------------------------------------------------MSLRRLVSDLGRMCLQTASQSMEIQQNRA------------------------------------------------IHASIRAADSI------RDAHRQGTR---------------------------------------IGTGQVETMEGTTGAGI--------------------------------------------------------------QTAVNTSSIDARLPTAE-----------TLKQQFDGVAYHELP------------------LVYIR--ASKNNTLVTVMDNKN-EVITSTSCRLEGFKNARKKTTIAGQTTGVAAGQR-LVRRGIR----TVRV--QVKGLGPGRMTCVKGLTVAG-----VHVVSISDHTPLCEL-GPRPRKIRRI-------------------------------MLPRLGGFLAGFSSTISSFLPKTTASTLFTHQSSQFSTSFPAWRN------------NFLQFIHYRNGPPKRRARSK----------------------------------DKSAISGY---------SHYKGIVLKTVIRHPKKPNSGNRKCAIVRLS---TGAEVCAYIPNVGHNLQEHSQVLVKGGRRRDLISVKANIVRGKYDCAPAGGRK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLRALRGAADLLSTALYKNEMMMSRRYLSTPAPEPAKPSSEETTESTEPATSVEDAGEPMKEKRITQPYS---------------------SEALTKLKLDQYPLYVEREWWKTGKRMTFWASW---RQLRDVKRREQIQEVGADRMRLKAIKFNTILPQAIR-----------DEAAEKMQK-ARKYDHPRLILNMCQFTGRQ--RGKIKPYRLSRHLFRRFADRSALSGVQ-R-----AMW--------------------------------------------------------------------------------MINLRRFVHTSCRLERGRTAFYNVHQKVT--------------------------DPAKQDPDYFEKKARELPLDQNY------------------------------------------------------------IDALTKLYYEKIGSERDLGLKAADNLILEKTEFGLPRIEKSKTRAKYED-LDVLSNAPESVKKIFSV-EMATRKELSQEWKQSLIKSVRQH--------------------------SLDENSLEMKIAWLTALIRHWSLLVNDIGQE--TKKKPTWLTHRIWLVINERRKALRILRERNETA--FEKTIAALKISYHVPKQPAHVKT--RKAWAEAQLKLRVENEKEKRLEELHEKYDKEVEEHKRETQEKRKALNNELDKLAQEMRQIDVIEGKSFETVGKYEPALISSLTETVIHSNLFYHPPPTMTEK-----------------------------------------------------------------------------------------------MRKLVIPKYYGRPSIGLALFGCT--NRPFYHVCVF----PDRALGRRYE-GNILEQVGTFDPLPN-------QKNE---KLVALNFGRLK--------YWIGERNAHISVPVLELLGLSGLFPIHP----------------------------------KSFIRAKDNRALIADQQL-----------------------------------------------KVAAEAAEAEKVAQEQASTGAAATSHPQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPKTSVWKTRVGTQILMGKITDITQIGIDRIPC-AQVRCQMNEFNIYLK-KYFARSFDFWALDKTSLGNIGDTVLIKQIDGSSRPKAN-VSHAVDRVVFKFGNIV-----------------------------------------------DPVTG----RKIFNDT-----FADEIDLKKVLVEEVVDKPLEEESMLFEERRALQIRRLEQEKEANV-------------------------------------------MLKSAS--------------------------------SLVRSFIRPQTFRLCSSSSTTQGSPSVSS-------------------------------------------------------------------------------------------------------------------------------------------DDEPVIL----------ENNPY-----TKEPRKSFL---CST---GVELDY---KNSRLLQQFVSTF--SGRVYDRHITGLCDENKK----KLIEAIAKSRRAGFMPIFVKDPKYTRD-------PKLFDPLKPIRPHSFA-----------------------------------------------------------------------------------------------------------------------------------------------------MVQNN-------------------------D--------VDGAFGLLNRLMDSEG-----------------------------MLKIIRR--------------------------------------------------------TQFYQK-------------PYM--------------------------QRKTLSME--------------------------ASTAIFNEDMNRKMK--FLVRKNRP-DK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HPGQVTS------------MLQLKPRVSALTRLSAEVRSASQWIKASNSKTPD----------------------DINVEKLFVEKEVQKLLTD-LTEIDLEHKVFRPR---------------RTSIQQRS-----------HFALMTEERLEKTR-ERMREEARRFLQFVPVKEP---R-EESVQILAKDLELKDF--D--TSKF--VFTDITFDATDQDRTVVVREPD-GTLRTANPEEHDRMNRTYYQKPNRSVNPPPLFS-DPNLQNAL--DKNDHEFVLDWACWFYEPDDPAYVRLSQLVFDR-INE-----------------SGKFHVVTSTRHFGPFTFYLALNDNIQK-LLNYFGG-LGRLSDCANLVRLQKAVR----PDWRVTIAQGDSDEKIVKDFAKQNARFRDEIQDLLNFINNGKLKSDQEQTEHVRERFGVRVDKRKARIT-SANIRGADGPLGDLSSEYSVKVVKSEGSGREGGGGEENKKDEGGRGGGKGRWRSREKRSDDDGKKKE-----------------MASFITRAERSGNIFSRVTGLIRAGQ---LNWADRPLWYDVYVSSPP------LTPPDWNVKLAKY-----------------------------------DEPIRSIFYEEDVLRAKFYKTYR-----------------STAGIQVDSSRT--SVSQQFINEYKLVKSEN--AEATDDQLFEMTQK---RLNENGIVLK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPFMHGSM-PLRRTFF-YLQ----QGKV--KL-----RDNVNVFSM--GFH---KNPTPEQSGARDFVY---------------------------------WNWAQLQYHNPKVQ--LVKHADKVVTPFARAYLNDGREVLFDLDGMKREEI--EKLLAKTLGKTELVE-RREHLESIAKLNP-ADFG--SKNERQCMCEVQGQHP--------------------CT-----------GLLR---APQCVTGKYR------WNHNLI---------------MLINSSRLSISSTGRCLLASAMSQMDEVFGVQKRQMGRRQPKQGKPPILPPSKKVLYHVVHAPWQKPEDVEELLWRRHA---YNNAVI-SLREVFRAELAQNASHGQGIEAMKEA----EALELDELIAQNEKRNEEKRAARKEREA---------------------------------------------EDAKETKSVILEEIRVELEKRNAGKKQAEDEVKNAISRSSEFITRSNLETKILEALEKPTIYDFAIDRAGNKY----------FVPEP--------VKYQEGTPTRQKGRLYDQTLGTQHGTIEEANKIQQKSV--------------------------MLSKNLLRTFITRRNFQKSIR---QPVLSSSFSLEKEWSDRHVALGKLGLGGDYEWISAVQKKFIGGGY-ASAVDVDAAVCVAEQKD--QVDDVIELLYKLRHSVKAAEKLESSEYAIVRLLLKYQ-PETIITLANDPINYGVFLNQHLACIVIDHFLKTSNIQAAARIVTWMIQQEEL-DN----ELLNILGLYVCAKWVELPVEQQTLDLGGADDEEEDINDDDIRTFKFPYLKNDSFDEHFDLSNPHHLIGKSLQWLSRDTKFIDSQ-LKSSLNALGAVLFEKLAE----ANSTIS---T---------AIPCVKSIVAG-------------------------KLAGKEEE-------AGVKNILESIGEVEEA----KEKLSD-IILEHLKKIQ---VSEEDSLCAVQTKLFGEWNERRQALAKSQAQKVLLRLRQDEIRGELKQLDEQEEQMSFFKNRLIWE----KRAAENTQIDEESKQRHKKKESTV----------------------------------MLRSLLKSRQVICGLRELRALSTSQGNES-------------------------------------------------------------IIDFVDTVTETSEAQN--------------QSFASLLRNSKFMQL--GDFNGRLVVGKIAQRVQE----DVYIDFGLKFNAVCKVPAL----NSEA-YRSGARVLIRLIDPELSERFLGSKHDLTLLEADAVLVRLLSNVPRQQQQRQKPRGATEEEAPAAPETPAAH-----------------------------------------------MKPCGNLMCQIARR-----------------------------------------------------------------------------------------LPARQLHISRRSNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q--------------------------LADVGTLSEI---------EMPVAKQLNMRNHLPA------------------------------------------PLSKQMDTLGEVVTLIREPMAEVASCM---RVVDKS----------------LPALRLVLWGAFGTGKSVTLNQAVHHAY-NNKWAIVHLRSAMELTRRVKE--IEM-SSFVQGR---------INDPSNSVSI---------LQNFKQQNQHIWKILGELLTERDYEWSKSE-RTLKGKP---ITEIIEMGISAPFL--------AS------DCVGAIFRELRRHAKD--D-------------KLKVLVAIDDANSLWGK--TLVKRADR--TYAPPSDLTLVVHYRRMIEND--WTN-GCVLMVADKKEVADARDHLGVSR----------------------HTPLELF---------GE-------EGFEYVEPF--VP---------------IETSNY-------TEAETDAIYNYYVN-----------KNWLASKAARSEEG-RKQLMHL-SA--FNPYYYERLCAFN---------------MHGLKRSLMIRTVCRGKATTAGADLPQSSQEIEVTTPKSENVPAKSANASTVYR--PPYYRKPHQHHEPKHMLQEEFVNAGDASGAGVRVFDYYKTAEMVHSMPTIKEKIDFVSPYERPWTRAEKTWRRDWHPTLMATRKAWGIPPTPAHFDTLDYYKYLTKTRV-----------------ENESLDD------FYHGLRPPTA-----DLQTSFQNTLKSMEFG-------DGINFSDEDTQKL--FGSLIDDAMGGIA-HNVSRLADHRVAYDVESEAFWVR-SGFMFLYDEEEIGTRDVKRRLNNFPKFIGDDRRKLGELAFVHRDKLAAQVRSKEPSAPL------HSFDSEDAK-----------LPIFDTNYNFEETLFSPKVYNL------------WPDQ----EPLWQCPGYH---A-DSGESHTYGILGVKSLRPLRKRIAHWMGWENENELESSEEAKQMLDDGARSQAIISMFTTLCAQAHTHGFTQYTDITRSFTSQLVLSDGINFWFAIGQLNTI-AINVECDGFVNPR--TNYIRIDGPYRLF--DYCDKNGQYLSVQEEIDAENKVQRKIAPGLNEKVLERVTQMLMKQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLRSLCSIAVRLGGARQPRLLSSAASGDGNDGKGAKDAIDEDLLNAIEGVANNIHPQNGSEKKSLKNTLINRLVANEKASFDAAAASASSEMLDDQALIGLLADVAGD-----------------------------AKVEKKLPPKSAQLRQEKRGLVLLRKEIFYQAVQSGFTTEEARVKSETIVNEAQ-------IKLQEQRKALLNDVREKVE-------------QEEVEETERSEKDQKLFTMALEFMEKIYKDDLISSAVRKPVKVDNDAIKLFNQKPLGIW-----KKGEKYEDFSLGFWKQWDERAARISNG----SFGPTNSFEEQIEWTTKGKQWEYPIDNEFKMGDESNVS----------FIDHVF-LERHLPSLGI---------------PKSGPIAH-FMHLVCVGLSKNPYMTAAKKREHLKW-FADYFNTEKQKLVHKLHEQEQIAAQNAL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAARLAASRIVHAGRGISQPTPFGKRMDRL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNRVWGEVVMP---------------------TDTKSLKVVRVMSAEPYETKEQLSPKYYPNLPM-FHYLTKMLRFHGLFFDDHVV------------------FRDVQDNLKIIRGKVVRPP----------IGQGKRAQLRGKK--------------------MSSNLIRFVGNHD---IASEG-----------------------------------KFLFEILSQLRNFGVGRLVTKNEWTR-----------KW-PNNPSYMKILRAEP--GMDR---------------------------------------------------------------------------WLFEGKVYAEWVFRG-KNLGVYEFSKDLNRSDWQLVHKHQEKSYTSSTTP-MQD--LVLPDSFPLPPLQVHLSQKSARKNGLDEKTVSRRAPLTLSVDPEFQHLKPFIKQEAPSTKSVSIYEEVDKNALLDLYGNELPVKVEAWNAGPAMFQPRFNATTMRVEEQPPK--------------------MHRLTHVSTRNRSSLAEKLRNAVG-----------GQDFGK-----------------------AKQIVAGGSIAVKDEHGEDFRELYVMPKRKLRGQ------------------------------------------------TQLEQATGRTEYKTRSRFDLMDRLTKRPP------------------------------------------------RSEEM-------------------------------------------------------------DPEAQKWCDV---------------------------------------------------------WPAAR----------------TFASSVV---------------------PLP---VRMG-------------------TRPNVEKRAPFKK--------------------EGNLELVKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNFLHLTPPAIQQHCQAIKK---FCTPFPPELLSNPSATCQHL-PI-SIEYSTYIHQGT-SIRDIRSRVVTMKIHVAEL-KLSENQMEKLIRLAA--------------------NR--------YDEKTGKMTIITDRCHTRQQNLDYAHYLLTVLYHEAQKVEKWDELKNRTDA-LKVE--------FDGSNTKTKLIDLLEKAKLTPGLSP-------------SAAGCGDQKSIDEFGEMWKAYRN------------------------S------EETVEKTREYGRQMKKLLGIQQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Capitella_teleta --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLKRLSSQSLRYLQRQCSLQSRLCSQTSSIE-ESTQTSINP----------------------------------------------------------------LEHDDYF--DVKRL-----------------------------------------------------------------------------------TKKIDLFNNRVHLGHKVGTRNPYMLPYIFGNRLGVDILDLDQTHELMKEALNFIAHVAYRDGIILFISRHLHTIPLVEKAAEECGEYSHCRQWMTGTLTNSS------------VKFGAV-----------------------TRLPDLCIFLSTQDTVFEQ----HAAVIEAAKMYIPSVAVVDSACDPRLITYPIPGNDDTPCAVELYLKLFKEAILKGK----------------QQRM-----------------------------------------------------------LDANQK--------------------------------------------------------------------------------MSRLLSMLQTPVGHAEASWALL---LRRGIYTSPVAQKNIRAGQIKSSIN--------ANLPLTYEQAQKP--HKIG----------VTKAWNSWNTSNLTGETKDSAATTLEDLFIRQFMKGT---WH-NYLAS--EVIIKRRLNVVI-----VSF-------------------------IA--ERQ------LNARNFY------------------------------------------------------------------------------------------------------------------------------------------------FLVGYTEEMLS------------------------TILKRPIKVEL----------------QTVRR-KRDMTFKLI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAASLRVVCSKSFQFNSLNYAVCRGLSNLSISRTSGLLIPSEPQKPQPQRQLGFLTELNQESL------------------------------WGGVTGVSNAGRKRGRAKRV-GRAQDINLNKGRPL-----------------------------GSGRDNILWPGLNTPVL-----------KHSVINKISQVPVNPER--------DERLAKIREQHSGFKRSA----PPPLVRGWTGARMGG----KSIGQPEAVG---DYEFEG-----FDSRVLEIRMVANMTGTIGRKRRFSSFICVGNGNGIAGFGSGKSK-NM-AAAMRVGKNRAAQNLMYIPLFEGHTVYHDMFVKYHKSKIFIHKKEKG----------------------------------------------------------------------YGLKCHRALKTLCQMIGIKDLHVR---VEGSTKNIRAITKGFFDA-L--------------------------------NNQENHQDLANR-----------------TGYHIVERRKERDY-FPTVVASPVDREVKQERMTNEEEDIE-----------------------------------------------------------------LDYERLYHGGRSEYKHPPRKQFYEKTVGWRRRYA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REHKARNQRHLTLLKLSGLVPKHFPSTQNSAAAVASDAN-------------------------------------------------------------------------------------------------------------------------------------------------------------MVDTFVHMKTLARGNCPFSCSGIAASSH----TETCSQRPVSNVMTASLPLRNALRCALAMGSLARLTY----LACIHTYYA-SFTSYFLINFDGPVEAVKPIK-----DFMTRDIDIIRPRVL-RKENEVGRP----------CHDGTC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFGE--------------LDDEKRRRLRVNLRNYIEKL--------------------------------------------------------------MAASMTKGVLNCCRIICQNSKSSASIYKASSPI----------WQ------VPLRNS------------------------------------------------------SYSST---YLEPTYRKADLDQPL--------DASDDRR-----------------------FLPIKAAKNDEV-------------STSTLDPLLNKFIRQMMRKGNKQISR--LVMDRTIERIKQF----------------------------------------------------------------------------QLEK-----YHKETSEEKRDLINL------------EPISII------YQAVENCKPLLTIQHAR--RGGVMYMV-PIPVKPSYALYKSIDWIIEASTGKHRTN-TDNRVWDDMAREFIAAAKNDG-----------------------------GAIRKKQ------------------------------ELHR---LCEANRAYAHYRW---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRAYLERAKAH-DAF----MQGEISEYE----IGK-----RHLANI--------MGADPDNF------------------------------------------SQEDIDKAVEYLLPSGLFDKEARPKMKHP------H---------------------------------DVIPKRKAAE------------------------------------------------------------FDV----------------------------DGRPFHTYF------------------------------------------------------------------------------------YTAKPQFFKLMHDAVFV------------------------LES----------------------------------LKKEEDKMLRRGEEAN---AD--------K-----------------K-IIIGASVWLTKPAVEE-KLQEKLSDEEYDS---FIRLFTRIIEHPISYAE-ETFIMQYRRVLS--AESMISSIPELIYDE-----AGRPYQE-AEGARKTSK---AYVKIWSQGSG---HVTVNGTDLLDCFPEILDREQVMSPLHFTNTLGRVDIEAR-----------------VEGGGHS---SRAGALREEALSPTSSEIPP------------------------LRVSPRIIKNNNVSFFG----------------------------------------------------------------------------------------------MNTSLRLPSLLVCHLST---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPAQVEGDGEP---D--------------------------------------------DLY------------RSIVLEMKGHDPTVMASYQKYLCMTCEELGIHVERVWELPK-CIERRSLLKSVHIYKKHFRQYESRTHFRNIELKRLTGSTADTFLEYIERNLPEGMALKVTKHRIE------------------------------------------------------------------------------PLPPHIRPA------------------------PKQVEDDSTITQ-------------------------------------------------------MFCAALRTAGLRACSCSCRSSALRSVKSFEGRQLSTSLSLLTLDK--------------------------------------------------DAVKEKHRLMV------RVTQEKHMD-----------------------------------------FEATEEFEDNETASQ--------------------------------------------------------------DVVVEHGHQESNFLIPTED---------TLEALYHGIPFRLLP------------------VAHIH--ASSNNTLVLVTDHTGKKQISKSSCGMEGFKHAKKSSALAAQASGLAAGKR-ALKQGVT----AIRA--TVKGIGQGRLPAMTGLKMAG-----LDIVSITERTPIYVN-ATKPRKQKRK---------------------------MMIGLSQLCGRLCRMSLSATQSIMSQPAQAWKASTLLTPPSTTVEPSRM------------TSLWQMHRKG-GWRKKKE------------------------------------PKRYTDGK---------PFLKGIVLKTVIKKPKKPNSANRKCVRVRLS---SGKEVTAYIPGEGHTLQEHHIVLVRGGRLQDTPGVKHKCVRGKYDLAKVKKD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSILLKVIRDVAFKTVFNEVPASLTKQALVGQPLLRSEPNAYVTQTRGR-------------------YMDW---VMWRDVKRRRLVAKYADQKLRVNGIRKNTIIPKVIQ-----------EIADKDMSA-IPRDAHASRTVPRCVLTSKP--RSTVHRHRIGRIQWRSLADYNKLSGIT-R-----ACW-----------------------------------------------------------------------------MSFLRGVGTAVSVSRRLLVSPHPCTTDLLSST------F----------------------ARSVCISAASNHGLKNDGKL----------------------------LTTSLPCVTTKRW-------------------RTRKGTVKIPYTKPLSFEHGGDSEWGPLVQFS-------KSDPQPGFEG-IPELESADERVQRLFSL-EFADGRERKQKEMEYVVKALQEN--------------------------PADTSTLESHILRRTVHIRK---QIGHCLEF----RKDKRSKVKLLEGIQRRHKYLKELRRIDGER--FEWLTKELNLKFTPTSELPPKLS--KKQRRKNEAREACWAIIQTKLEALKVKLEKEKAEFAEHKRNELKSIETELAELGIEMQPTIEETVKQIDIGREVFKREKTVKRRKALLEKKFELYGLHKRNRGKDSRIKFV----------------------------------------------------------------------------------------------MSKHLAIRFALHGCA--NRPFFHLVVL----NQH---KARN-SRPIEVLGSYDPMPN-------QNNE---KLISINFERLH--------HWIG-IGAQPNKTAAEILGLAGYFPIAP----------------------------------MTYIKAKRNRKILAEREL---------------------------------------------------AAAETETTPQETAL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVRVMKMELDPYLN-MYFNKAKDFWCQDPSKQSKMHDIVLIKPLEEPMT--AT-VHHYIHEPVFPLGNIR-----------------------------------------------DPVTG----RRCRGPD---------------YID------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPDQL------------MSNPF-----VKPAKKCLL---CDL---NVDLDY---KNAKLLSQFISPH--TGQIYGRGVTGLCLYMQK----RVALNIKRSRNFGYMSYMAKNPKYLKD-------PKLFDPYRRRK-------------------------------------------------------------------------------------------------------------------------------------------MVNGHKIYNFLARTVLVKNN-------------------------E--------IEMSLKSLERVLGQEQ-----------------------------LYIRAKR--------------------------------------------------------QMFYEK-------------PCR--------------------------KRQRIAFE--------------------------HAKRVYDAEMTRKIE--FVVRKNRV-DP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WLR-----------------MDLCKMIST--RCLQTLKHSRSVNPYLFPQAIGSQC----------RHY------SKSVEEQFIRPEVQEILKR-VTGFDL-EKIFA----------------VHPTDVHPP-----------KYELLTDKQLSDAK-EQAELRGRQKLQMPPVMSH---P-VDEEEIISEEPEIENFDIEHPGAKY--VFTDISLGVKRRMRTIVVREHD-GTLRKADWEERNRILQVYFPQKGRMYSTPTMFM-EESLESLL--AEGKYCYILDRACVQFEPDDPNYIRVTQRTYES-INS-----------------SHDFDELRSTRHFGPMAFYFGLNKQLDN-LLTDCLQ-RDLLKDAADLVHLHLLLH-----------------------------------------------PETKSSAESVDLNDALATVKFYIQHE-AKNSGALERSLQGLVERTQAKESSAAGAS---------------------------------------------------------MAGSRAEKIGTVFTRVTGLLRSGA---LKHDDRPLWYDVMAAFPP------STEPKYDRLKLQQ-------------------------------------PPRNILYPEDNIRAKFSMAYSS----------------PGVYDMRNPNDK--SICQKFVDKYREI----E-KSTTEGDIFEATAK---ALEAEGIHL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPFMRGKG-ALRRTKE-FLE----KGEI--LL-----NEDIKVLLF--GYTPLLKKY-PHHTGLTRFIF---------------------------------WHLPQLKYKNPKVE--MYTFKNMTPTPWIKAFLKDDSHLVIDCDSRSREDI--HSHVKKVLGKSEAELLEEIQLEESRFHNP-ALFG--FQFDRQCICEVPGQVP--------------------CP-----------GWEL---FPKEMTGKYKKAQ---WEASRENE--------------MFPRLRNFLTRSNPISEALQLPDSTD---FIRFVRW-RKRRW-----APIPASKMYYVRKPTPVNEEEKAELLERNRK---YATQMR-SLRSYIIEAAKTEHDAEHQAMHLEE-----KRKEMEAIAQLNNKWNEETRLIREARVA---------------------------------------------AAKKIHEEKLLSQMDDLEMDKQKRAERARQRVLEAQAVVPTFVDLSDLEREIDQALNTRVSYNWAVDKDGKRY----------VEAPD--------GSIEVQDALQTPSKVEEKIKDPVQS-----------------------------------MASCGLRRLVLQQKHFKTFLSYSAR---RTLLSEAYSCNDAWQRRLQDPVLLKVDAG-SFGVKLQEQF-DIVGRVSAIDMDIFANKLIELDVVQLDFAQQLFQRFRRTDETVRMLESTPHALIRTLLDLKEYSRLMTMLKDKIGYGIFLDDISANLLMDHFIKRNMFKEAACIAFDLMLQEDW-SH----PLSRRLAWYACHLRLQQLQASPEE-----QTEGADEDEEEMQYVKVKYILTPWYDDHFDLNKETQLLGKTLVSITRQETGT----LALSYQLIGWGLYEKFEQGLALLQTLVG---GTEAGSVSANALKLFSEALKNIETKEKPEQEKSAGELTLEDVRP--YITQDQKE-------AYIQQLEELLPQLDSSARVNEQFMEGEALFALTQTTV---EKMEAIDVEDQNAMFKEWSQRRQDMLDAQIQAARTKRKKEEIVNRLLALKDQEERLSYFDQNDQIT----V---------GMSKAPSYKSLDMI------QDEEQFVAAPGER-------QRKKMAAPMRLFRFCLSSLNSRFTPIYRLSSSINNDSKSGDMTPDVNDQPEKITSTDTSVVDDQNLSDPSTMGDNTSGKSKGGLDK------------AFAMFDRVDESAAPETPPPSKPDADYPDTTESFASLLRKSSVVQL--GDPDGTVVSGEIFEVVED----DLYIDFGGKFHCVCNRPDV----RSEE-YRRGAKVRLRLRDLELSSHFMGATRDITLLEADASLLGLSKK---------------------------------------------------------------------MFSIVRPVLRRSACACRLITSSSSNNSSTEQ------------------------GSGTINFNELFQKGIENPIRNPVKKG-----------------------------LAVCRTNQTDPSQH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T--------------------------IRHEGLYYRV---------APEAIQRWMKEG-LHP------------------------------------------DIYPLFRAFNESCLMVRRPAIEIMECM---RAADYS----------------LPAIRYMLYGRAGSGKSSTLAHLMHFCG-SQDWVITHVPWAPVLHRYSKE--RVP-STFKEGR---------IDQPADAAKW---------LSRLMTTNDPL-LKTLNLKTHRKYIWSRRE-VTEEGDA---LTELIDFGLQRVKY--------AP------DVMGAVIRELKLHASS--G-------------NVKVLVAIDGVNGMWEQ--TRYIREESRHKFFHAQELTIVQHLMEFLKND--WTG-GASVCTVDEGATIKEMNDP-LTS----------------------YMPRFLL---------GQ-------KGFDFLDPF--IP---------------VHVPDY-------SDKEANSCLDYYTD-----------RKWIQHPAGLTEAG-RTEMFFL-SC--KNPLELYKVSRRW-----------------MAAPVRCHLKNNIFKHLRSCSRVYRPSHCKQSTSAASLQDY------EEPQY--PSI--KP---RLPPGVWGDSQPKW---------AWQQHERGEELKSIPKAKERLEELAHNEQ-----------------ITAYRVHGLHDTP---RTLEYKKFITKTHL--LNGLP-------DAITNCDVSE------LVAKLQPFIE-----EAIIEDHNQIRIEQPS--------DVVAGEYQHQEL--MSAIFNTILTKLA-ARHDYLRRAQVDEDVRIEAFWAR-SGFRE---------------------QYARAKDNSGVTRFNYKNLASLQLRSELPLPEF------VSPDDAVCSSE---------FPALP---------YGPHAI-G------------QNLIR---DKPMSISGHW---I---GDPCEFHVMSWLMVPR------QSR-----EKFIQKTDEGYYDEQ-LLQYGLTSSFASCVSQSHNQGFNRYLDITYPFTTQTVLTDGQHFRFFAYQLNSL-HIWRPD--DAWRV--QNICWASPNMKLF---------------DSV-EASRV---V--GFNPDVLRILLQMYLNQPQ-DRGV-DLRPYLPEDESPS-------------KTKDYVNVI---------------GEPVIERPVIGRLQY----------------------------------------------------RADAVYF------------------------------------------------MFKALEKETDTMAKALPGNQTENRQELIAKLQQMSIKKVRKHALGSQNKVAQLSTKGLRRSNLEKEEDPDSSDSSDSSDDEDLKEELKEASKIVAKALPPDTGKKRQAQLQ--------------------RLKKRLMEEAAVQGREMRESREIEPSQSKKEGKISKKIEPTKKFRAAAKEKENKEAETPQSKEETS----KRISDLIKSMDVKIHKTVH-----------------------PKDMMEDSGKRRGGGGGDRRKKFGQPRNAHGRSPMSTKHLYEGPALGIF------TKDGAPLDHLVASEPNFFDSLEDEIHMEEIELPPMTAYQEMMQWTKQNKTWRFPIDNEWGMDEEAQVG----------FHEHVF-LSHLITD--F---------------PK-GPIRH-YMELVATGLSKNPHMTVQEKHGHIEW-YREYFADK-QKLVDELIEADDVA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSEYSRRMGIL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GARIFGEVVRP---------------------TNKQSMKVVNMFAAQPNQKNEAVC-EYYPRHNQ-IFWLMRNLRNMGLYRDEHQD------------------FKEETLRKRALRGK-SKPA----------KGEGKRSQKKK------------------------MGPVMYIGRE----TSFKG-----------------------------------KRLFDILCRLKNFGVGRIVYRNTFHE-----------RY--PEPSYYVVKKVFP-NMNDPIGDVAYTDIYVFPSGEGTGDLVGIPLNELSLQHGLEAGITGQIKRLQLPSAVWRHVHQANVVLTKKAHNVLHMDKQLTKGTLVAQAIFRG-EDKGE-RVVRAGFKNDWRLVPRHEEEEFLSREHK-PLP-VNIVPKQCEFPPLFEHFLLKDMQYHKMDTSV-----------------------------------------------KPMLPLIVKQGIDNRAIYESEIESLEEQLGA--------------------------MASADQISHESMVNQSL----------------RFKMAR-----------------------SSVSCKYSEFSMV-------------------------------------------------------------------------VIPGHNHTGDSVERRRRPELPVIPP------------------------------------------------REKSM--------------------------------------------------------------PIDQDWTTV---------------------------------------------------------WPTAS----------------TFKWSAV---------------------PLP---IRQGRVFVCFKNFSESNIFNYFHSQKAEQDGIPPGK--------------------YGNLELMKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNFLHLTPNHIKKHCAALKE---FCTEWPEGLETDEKCKKHF--PV-EVISSDYIVDSI-SLRDPRARTVCIKINLSSL-DLDSHAKDKFIRLVG--------------------DR--------YNADTGELTLELDRCPMKKQNHDYGIYLLSALFKESWKTEGWESEKTVDDM-EMYV--------WSMNESKKNTQQITEVMKKAAENPSC-----KVPEYVLKSENVLETEPVQEYAAAVEDLHN------------------------V------GEDLHSLEKYKEQVKKMLLAQ----------------------MCQIVINWERYHKATEAVHRRSEA-----------------------------VRAHV-----PLIK-------------------------FPSRLTAEV---PNATTAAPSPLIQTIPTTANELFQPQTSTQKSGIPKWKA---------DEQPVGKTPRGSGIDF----------KDMPAKYKRRPIDEEEIAYILR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------G---------------------------------G-PE--------------------------- Capsaspora_owczarzaki --------------------------------------------------------------------------------------------------------------------------------------------MCSSRQCKRPYKTAFPAPPTTTAHNTPEQQHQHHAALQCATVVLRSMINPHSLTLVLSRALSLSLTGLRGMRRSCSPATAAVTAAVTASAVYGSDAAVHGRQQLQHRRWMATASSGFGSDKRAKPTAASPASAAAAADFMRAQRQSDLASSPESLEQPLQELEEDMEEDGEEAESKIFKAQYTDEMEDDGAPELDDPRFTVENVKWLQRVLNMQPSERRAEWFGLLRKDEPISDSDLTFRVGVLSSWAQRRAESVATAEAYTTLAMDQEAALAVEAAEEGEVIEPAEAPGALDEGALQLDFDPSMNKMLVRRSDDATPRPVRPEDEPVPELKEDEELNPEGLGHSILPAEDFETDLQNFIAFLAGESPRFGDEPAPEVPEAEEDAYKTIYPAEAANLTKTLHTQKLEREDAAMADVLHELIGGTPLAQFQPDLVAALPITPQVELEEIGPMTLSSIDLSLHVLMFYHIAQHHPSMLKASNAETENEISEDVLVIRHALFVMLEPHLVTVKGIKAIEAEAMDEFVHLLHELLPFQFSGPRFNGQLLHMFFVEAMSGYVHTGTRLDRAVDALLLRTIPRLREIYAMPALKPALIEDFAPIADRLNDGELRRLYRKFVPREVIDDGFATAGVSSLIDQMD-VLGTPSVGDIAAMPQVTIVPRDVAMNARDVIAADTRAFVIERAAEEESDRPIATPIEDEEERLQREFSGKSSSMPDPVLFAPGQHQRTEAFFASLPLGRPAEAVGNAIVEPKLFLSEHS---------------------------------------------------VTLRQLFDAGVHLGHKAGCHNVFANSYIFGERDGIHIIDLEQTIVALRRACRVLKHIAYQNGVILFVGGRSKHKQLVRETAMSVGEYYIANKWMPGTLTNPM------------STLGA------------------------LRQPDLIVL-TCMPM---S----SQVAREANLANVPTIGIADTDCDPRQVTYSIPANDDSPRSMALLLNVMRMAIEEGK----------------TKRQ-------------------------------------------AGLPLEYGPTPTNAPFSYTTSL---------------------------------------------------------------------------------------------------------------------------------------------------------M-------------YKKFYRNQSNKLIKSSLAFLE--QTKSQSLRGHVSGITVRIK-GRIKG--PIAQKQMFKAGH-----VSS-------------------------KT--LNK-------PVRN--------------------------------------------------------------------------------------------------------------------------------------------------YNHQIRTQV--------------------------GIIGVRITTG---------------------------------------MKVQLLSLWNK--YKRGTKQSRYDTIRIS--------KIRKI----------------KH----DYGNLKE-THTI---------------------KQACLNR-------------------------NPEKLVS---TLNKRLDAILVHCNWSISIIEARNWIKLGYILV--NNKI---------------IKYGGYMPNIMDLITVKTTD------SKGETIAESIRLRNGISKH---WS-------------WLKKLR-FTKK----PAISKLS-FLKSRKKYLGFKHKND-------------------------------------------------------FFKKSGKSLNSIKSNKSLKSVKLA--------------------------------------NIVLKKKIAMESANNAVKSLKP--------------------------------------ANIALKKKIT----------------------------------------------------------------MLVGLPPRLVLLSSGRSLWTCAAGSVAHAGSTTGPSAAAAAAAAATTSAAGAQQSSQVRDTLPGPRRSYRPVVRAAYKGGLQAPGLEGQTARRPTKREWGQAASTLSRKQQIAL------------------------------WNKQDAATPLEQRNRRLTDR-IERNVVFRPSQQVVEEIV------------------RDHLEEQSQAREPDDEPKSRSELL-----------PNLKFLRQLRNLPDSAR--GTSSLAGSGLEDLQIDLKALEDKA----MPTDEEAHARRIEAA----ADIYHPTNPLSIRTKAMVHVISRGFQVRLVEVKRVSTMLRT-GRRHMMQALALVGNGRGVIGFGMSKDA-VA-QQAVHKAIIQACHNLYPIPRFNMHTIYHPMENKEGRSLVKMWPAPQG----------------------------------------------------------------------HGLVCHGVIRMIAELAGISDLTAT---VINSKRNYHNIVRATVFS-L--------------------------------YSQQTARDVALK-----------------HGKNLLEMKRIPALTRPDFL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRASLDDEHAGRSASQIQPQAAMPTYEAMFMMR-QCKKHD----IMSLCAQLFATVHKDGGSVLSF-K---HFGL-ELLPY----RMRGLGSSH-LTARRFTINMHVSTLAVPVLE-----SWLKAHQSVARYQLF-RTPDLWKQQ-----------KRRACARVASGDPIKDLTPVSTLPVPLVRTAGGGGRLNLVRSMVPAARLSGEKQEFFYPPDRATVEATAQQVFSSTGSMIVEDFVKSLGFDRAAFSEELARAVNEADPSESPVSSTDALQQLRAHVLTVNELVSRQSNSAGVHLNVPRNILPPRQAAMDLFADNNDIQAVGTDAPQPVSTSSGMTPLVFLVQNAASMTVPELRRFLRARFEEAFKLQTSAQLAKVDTAVPSGSDASVDLDALLLSLTPSSDTPSSSTADDAEPVATSASQSKWIDAAWTKVRNDIADLESEFESSASYERVQKIVDRLRRSKEEADV-----------MLASSRLAAQPLLALRSSARRLLHSSNASQTTTTSAAAAAAAAVTPSAHAQLDSGDAIAKAWLARVADGSFAQSSSAASTLEEDPVVQAVLDNTYAPARDQHAEATSETAGFEPLTNTTLSRLRPHPHVKYPSTLYGSVRPRADNETLRQAFFKPRVDALMKTRQAQEEAKGTAASYTYNSRVEALREQAAMHVKFVSGRKRQAPPPLTSTMDLMHTIGSDPILQKLVNCLMESGKKRAAQ--KILIDTMIFLKMHFVGTIVPMTRPLMSATEAQAARRAIYEQAASAAAASASAAASDASASQSSSAQANALDLFSFDGLLPSTTTTTTADSVSQPTLSVSSDLEGDQPSAEVVAGAEFVSDFK---TPLEFFSVLDMLHEAIDNVRPLIELKSTK--VAASTYQV-PFPIQPARQVSLALKWIIDAARKR-----ATHGLAPALALEIFDAYNRRG-----------------------------TTMKKRM------------------------------DMHR---MAEANRAYAHFRLMKRK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLSLVRRRLLSTTTSTSVAAAAAAATTRAMAHTKAAAAAPPVALPRGFGWTSQQAAVEALLPEGLVDTLNANRASALGVAQDQQQPSARTKPEGVSMEDWVQGEQQRVADRARARVKTQLLADTTLTQLSQGWEKIKALADTELHIYNLLFGVNPPYP------------------------------------GAFFDLPNEVVTRRLKYLFPTMLKPPQVDASSRRPHHGMKNQLTDRPTSLAHFTGQPAINDKLFELDAIYDRLSRDAYPPVRAAQHLHAFTGSMLSANMFAVEGARALDGAKLPSRQNENCMDEVVFRAALDIDRVLTPALNDTVLGIPQLLQAHLDSLAAAEKPA----------DATPASLLYQLFLAPSALPGNAHQVTILRGLVIEQLRVRQSDRSVRAGHNPFVVLDRGTLVPVTFTDASAGSEEPKLLRITDEVLLGTAESSVLPCEPTLYDVLMAVAHR--------AALLFPSFEAFPSITHDGKLTYEAARWHVATHLGEEGARAFDHVVDQISLAVPFGPRDGSWQEPAAEYRALAATGAAGVPSTSLLQRIASATPHSVLVRAR-PRTPTTGWLRREALEQ-QLSMPLSMAMHRR---VTLRLTKIARLPNGHIV-SNYLNDHRES----RRASSARAGERKAHP------GNSVVT--SGRRKASV---AVVR-LTRSANVDGTITVNGQPLGKYFNVPVPIRTAILPLELTGTLGFFNVNAT-----------------VKGGGLT---GHAGAIREGIMQGIIRFFPE-FRPLF------------RKT-GLLTLDRRKVECKKPGRKKARRAFQWVKR--------------------------------------MLAAVVVRRPTTAAQCYSTLLSSPQQLIRRAAVAADAASVTVAVMAGRSGLAASPCGRRAISGFAPGSSARAPTDQPPAASASSSSSEASYGGASGRKSRRGGIRKLTSAEFVRQLTGQPEPRHQEDALLQQVDAFGGQVTKALKQLAEEPGKTHQRMSRLRLEKQQQDVLASERALHAQQVADESGRSVYRRAEQIELRGALDRARASVTKPRFVRNLATPGPTNTIVLPAGMDMAEGVESPAEPEFESFKPREEDALAYEQNRRKHLDERMTADQAWNRAYLKARENEQILSSELVSKSPAPSATALDKDKFDALTQKRAYLAAGAGTKIVAIEEASGDSGIEAAATAAAADAVAAFTKKLGGANDVHAVADHVAAAFGDNASSTVDSSSSTTTTTTTSVVEDEDDGADPLDAVNMMQVDDPHLLKLVNEISRMRQLYAEKLPNRNHEAAGEAQLL------------PAITISLKGYDWSVLESYASFISMFGDFAGATTTGVLLYPT-HTKRFVVLKSPHINKKHRDIFVRNTHHRGVRISNLNEDTLQKFLQIVEREIPAGIEMRVDQFSYE--------------------------------------------------------------------------------ELRFSPR------------------------DWRDKYEALVQSSAAN---------------------------------------------MLAAAACVCSRIASTQGLLRRAVVAGTASRSISVLASVAWSTGDNNKPPSSL-------------------------------------------------DWLNATNADAAAKTAAAKAAADAGAQRKPNPLNIGFSVDELQAAAAAKSDKGNSNSDLQAFFADFTPEKKPESEATERKAHPMHQGVSVDELQAAAQRMGERSKVDSDANFASFLADFNAGKQLQEEADAARKLAPSDFNPAAVQADIAASTKDVTTPTEQEARALLSKIPAALRADFEWSAGLAPPRPEMLQLGAQIIDPEQADVLRIR--FTKNNVKFVYSTATG-QMRYFKTAGSAGFKNAKRKSTFAGQQACYQVVQH-IMTMEKRRH--PIRV--FLSGMSVARSSVMRVVTNSP-----LNIISYTDIS--------------------------------------------------------------------MVTLNQLVRKPRIRKNRKVKSAAL------------KLLSYRNRVS-TLKHHSK-----------------------------------------------------PFVKGICTKILIMKPKKPNSAQRKLAKVLLK---TGKTVFVSIPGIGHNLNDHATVLVRGGPVPDLPSVQYKMIRGKYDLLGVKNRRTSPSKYGVKTSTLKTTK------------MKKLKLTL-------SKIDSTRKIKELVSNTNTK-SELKLANLLQI------------TDQLVTNILQNKVTTAIL--IRRSKKN-------------------------------------TGTWHSWRLSNGYPVHGQRTHSNAVIAKKKNKI------------------------------------------------------------------------------------------------------------------------MFKLRH---------------------------KTLKDQKRREQFKEVEMTRNLYNAIIHSSIVPSIVK-----------VYAQEKLYN-LPVDSAFVRIRNRCIMTSRP--RGVIGQYNINRIKFRELVLQGKISGVKLR----------------------------------------------------------------------------------MLSIGSLTAAAAPKAVAARVALACVASSACTIAPPARFGGTYRPRIKQQPPKPGVLRKLKSPPKIENAYRADIPELDLSVSSRLSTPEARTRLRDFDRLKAKLDKLEAESATNSNADERAATARYVAETLSAADRQTKFLPVVGKEHDRLTGGKFKHHVATMEFEAKHPVDLTKVSLRREGSTALLPNIVSSQSVEDFVRSSPALSQALSV-HMGTQTEVVTLRKREVAADLQRH--------------------------THDTGSAEVQVAMLSIRIQQ---LIQHLNSKTIGRSKDHRARRTLMLLAARRRRMLLYLQRQDVQR--YFVTLKTLGLKTIVPANKYDSFE--RARQARVARSKSKKSSRGHQVPKARHDWRAAEQAEYVQLVQKR---------------------------------------------------------------------------------------------------------------------------------------------------------------------MLMLRLARFGQI--HHPVYRIVVG----ERG---RRRD-GKHLEHVGTYHPEPD-------TNGV---RRVTWKVDRIK--------YWLS-VGAQPTER-------AGILPLHP----------------------------------RTTSALHAQAITPSVFTY-------------------------------------------------QAQIRPPSDKKDEPAAPSERPVKLPAEISSPLLD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRKT----VKVAVVRYTKHPYVDGKVLKHEKNFLAHDEEQVCFVGDVVRIQDCH-PIS--KR-KHFMVVKVEKPVPKFV-----------------------------------------------DPDTG----FLFTTGM-----------------------------------------------------------------------------------------MLRQPTSSSTCARALVPQLTI----------------------ARRTRHSAATATAVVAAAALVSLPSGRAAASHIRSSTAASEISHSGVAALGRTVAVATAAVRARSTSAATPVALLRR-------GIVGQPAMTGARSMSSLPSGGNPGPFGSAGAMSPSDYRADDADAGASQPLPSDVLAELLGEQPRNSRSDTLTGDSIYKPPAVLTTDEPP------------TAVPF-----TRKKKLCPV---CST---GIVVDY---KNIAFLSQFLSKH--TGSILPRSVTARSHEGYQ------ARTTNGTTTVQ-LPYNFKHTSI----------PEYQ----------------------------------------------------------------------------MYTRMRSAVIIPEWLNKKIGVYNG--KTYIPVTIKLSMIGHKLGEYSWTTKPAIFVTKKGAKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLGALRLVSVCGSRATTARATARAIAASALPATATPRRFASTSPARSDEAEHATLNGFNFTVPKPRQRATTAEDEAAMEQRRVVSLQHLVDALKNMASPELATGSRVKLRGVTNDGISK-------------------------------------------------------------------------------------------------------------------------------------RSDLEASDVNTLPIVTHGSAAASASKAKAARAAVPLADTPEEIAAEAASAAAAAVAINTAAS--------------------------NSVIVDFSRLNLPRLTFESAWDSLPKLFTQQGLPQELNPWLDGVLSLKHSEFDSDDVSKMIILQLERMRLLAPSPPSHLGNTFVNLKQAALMLRPQVFELYRLF---------------------------SNPWLQPSVRGTGKSVALLSLAYLSSLEQQTLVMYIPDVHEWMIRPLV--LMP-SLSQPGQ---------FNHVYEAQRI---------LVNFEALYSEQ-LD--TIPLSKRRVIGNLP-PFTVDMT---LNDLVSFGASVPEI--------SV------EILTAVLEELREAQ------------------GYKVVIAVDGINALFSK--STAADSKG--KHIANDNLALVQLFRSLLEAKPERSN-TLFAAALTASHLPSPSEPIFQQVMRLAEPVLSEPEDFLAPQLEMPTLPISVL---------RE-------APFHNLPQA--ARIV------DGRSLLKITLPNF-------TDVEMVNMLKYYQL-----------RGWLN--KHIEPVS-VRTMRTM-TE--GNPRRLWDAISHM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFRPLGSALRLSNALRDTIAKT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AADTFGHVKTPRIVRETALLENPTDNLKLAPLVNQKTFRTATSFLRRPL-IGERVA-SRYPPYLA-INSVLKHLHAVGQLANEEES------------------DRLFNLDRLRKRGK-GAPK----------KGQSKRANKKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLSAAAAVRTSCRSERVAAAVAQTVLAARGVASMPLATTRAGRAVGLAPAWVAMAGNARSQTRAVSTSASSSTARVSAAHLAQAYRGKHTTTGLSLSSGAGGAAGGASTSWPSVGRAIHSSCASGASRHNKGPLSAAGSQEPILSQADVDALALQIASLPTEERAAKLGALLPTLPPATATRLAAAAGVSVSAVDAAYRDGLAKTQGSAVSSAVSAEEVESDEVLKEEDESPLSARHQHTRFGYQDDAPSNPLAALKKVAASNSASTRQQAATPDSIRLQYDAHKRATDAHSRAKRAWEAASQEAAKQPDVSTAGLIERLRAQSFTVKSKGVEALHGGGTHVTASALFNSGHRQIRLHAPAAR----QDELEELLEKWIALTWATVNSEMTRDFAKTLVDREATPVASTP---ATSGSQDFALLQMSDLMPLDATFLRVAQREFLASHK--------------------DVGFELIRFMPEPRTSGVTMCVAAPAVSEFDRLSAVDAPDAQADSTGKSWRMLSLLAGLELTTLGPLSAGGELVSDMGDFPLLPATEPNAQELSKVRDNPSPPLDRRVAHRDTAIVATFRSADPTQAELLSIHGVQFENDSDLEERAPNQAPKYDEQDADNQFLDNLSRRKAAGHSITEITPSNFATTMNTERQLVQDFLDMPPTRIRQMAEDFAA---RTAPFSHSDRR----------PV-QFVTRHYITVTS-DLPPGGSRKVVLQIPLSEL-ELPSVVEEIFVAMLE--------------------TR---------IIAGKTVRLVSDRFPLREQNQDYLRDLLLVLVQRAYELALQQPSLPLTAH---------------------------------------------------------------------------------------------------------EQKERDLHKYLVSSPMAGTAAASRV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Daphnia_pulex ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIRTITNRFSWKFGRCLTQTCSITSDTSHCQNATALKVNQPTELKESELKEITNP------------------------------------------------------LRFPDYF--GVRNL-----------------------------------------------------------------------------------FRLKDLFDAKVHYGHKDGTLHPNMKPYIFGSRLGHIIFDLDKTTELLQDALNFTAHIAYKGGIILFVSHYPQHTLTVENAAKEAGEYAHAREWDFHLLTNSE------------KIYKGV-----------------------TRLPDLIIMVSTLNPQMQE----HTAVRDAAKMCIPTIGIVDSNSNPNLITYPVPGNDDSPTAVQLYCNLFRDAILLGK----------------SKKS------------------------------------------------------------EIPSS-------------------------------------------------------------------------------------------------------------FHASAACCKV-QSGRYKISPK--------RDKALTYEMANPP--HFIA----------HRKSWNSWDTTSLLEGQRAAE-TSVEDVFIRRFVSGT---WH-DQFCS--EIIIKRQHNLIR-----IAG-------------------------II--KQG------LAARKMY------------------------------------------------------------------------------------------------------------------------------------------------FLIGYTEELLS------------------------NWLQCPVKLEL----------------QTVEN-KEATVFKYI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTTPLVSSKMFNPVVSPVRHTSFFTKLPADKL------------------------------WKGVTSVSNAGKKRGRGRAV-GKKTAKNLNRGQVI-----------------------------GVGKTNMLWPGLNSPII-----------QGKELIQQQKLPDDPER--------EAKLLKLRDEMGAFRLLR----LSPLDRGWSGPKLPG----RSVGRPDPVG---EDDFEG-----FDTIVLEFKIVCNMKGNLGRTRRTSAFVVTGNGNGLAGFAIGKAQ-MG-MTALRKAKNRAAQKLMYVERYNEHTVMHDFFTAFGKTRVFVQKKPEG----------------------------------------------------------------------YGLVCHRVIREICKAVGIKDIYAK---VEGSTKNVQHVAKAFMVG-L--------------------------------LQQKSFEMIAEE-----------------TKLHVVEFRKERDY-FPQIMAKPSEVKTVKSINDMD-------------------------------------------------------------------------LNLYLNDGKVATKKKKYQVNESDPTWKNHLS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTERFRNHEQVRVNLLVDHGEVRSFLADRYPECRQIKFVKRREES-----------------------------------------------------------------------------------------------------------------------------------------------------------------MPSYELSLMLR-VLSKPE----LVSSLKRSAETIVQQGGVLRQF-I---SIGT-KPLPF----KIRAHTQWH-REGTYFLMKFDAPSSAVEHLN-----DEFKRDIDLIRTHVV-KCEEPVKQE---------------C-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLEEEL------------KSPAYRKDVQQLVEESRKTV----RKQFKQNSPGFDYYPFQK-------------------------------------------MSLSGLLRTLPTLNAINSSLGSLSLLSRQP----------YS------------------------------------------------------------------MYKPF---VKEPVYNIEQLDKLI--------ESGEAKKRE---------------------FVPVKAARNDHN-------------VSVFYDDLTSKFINMVMVKGQKELAR--NLVEMGYMKVKQI----------------------------------------------------------------------------QLAK-----YYEATTDAERAEIEL------------NPITIF------HKALENCSPVLQLTPIK--RGGSTYQV-PIPITENRARFLAMKWMILECREK---E-RKIHFPERLAFELIDAFNNTG-----------------------------KVVKRKQ------------------------------DLHK---QCENNRAYAHYRWG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAALREVLIFNSKCFRGVRSYFCSSPA-F----QYSSLSPNNASS-----------NVQKLDFEESDTKRISKAMKSYMERAKIH-DNF----IKEQLHQYN----IGK-----RHLANM--------MGKDPEFF------------------------------------------TQHDVNEAIRYLFPSGLYDPRARPMMKHP------D---------------------------------EIYPKRKAAE------------------------------------------------------------FDM----------------------------NGRPFHSLF------------------------------------------------------------------------------------YTSKPNYYNLLHDLAVK------------------------FKQ----------------------------------LDNHEDKMIYRGIQDQ---QA--------S-----------------E-LFLFGTDWVSKESVES-VLLESLTDSQYSN---LIKTMERFAQHRYAVRE-KNFIMQFRHQLA--AQTEIQKIPELMRDE-----SNRPFTT-FSARRKRSN---ATVKVIGEGTG---LISINGEDI-LYFKRKQDKEQIIFPLEFCNMLGKVDVVAT-----------------CEGVGMS---GRVGSIRLAIAMCLRCFVDAETIERM------------RLA-GLLSYDPRERERKKPGQPGAREKFTWKKR-------------------------------------------------------------------------MSHYLRVINKSFSNILGENGMLHTFINN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKVHLVRNNLIPRRLYSTSNSVNLENHSEKK-------D--------------------------------------------ILY------------GSVEVEIRSGEPAVLLSYEWFASYAAKQLGIKIGKCWAPQKPHHHRLTLLKSVHIYKKHRVQYEVRTYFRHMIYERLTESTMKTFLEYIQRNVPEGVSLKVSKKSFM------------------------------------------------------------------------------NLPAQLTDH------------------------VPSVTLK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVAS------------------------------------------MPKLDEGTQGEK----------------------------------------------------------------LFDVPYDEQTNQFPDEG-----------TPNRLFDGIRFADLP------------------ICDIN--ATPNNTIMTLSNSAG-CVKIIHSCGREGFKNTREGTNIAAQATGITLATR-GIGIGMK----TVRV--TVAGLGPGRMAAIKGLTMGG-----MNVVSITDKTPVPWVAYPRPKKRRKL--------------------------------------------------------------------------MS------------NLLLKMHLKG-PHKKVRP------------------------------------PKNPLSGS---------PMLKGVVLKTVIRKPKKPNSANRKCVIVRLS---NGKEMCAYIPGEGHNLQEHNIVLVRVGRVPDLPGVKLKCIRGKHDLGHVIKKK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATTIMNRLFNISSFICQNAAQLLKNGANNA-------------------VKLDQPVRKN-------------------WTDW---RMIKDNKRRKLLVQHAPDRLRMQAVKKNDILPAEII-----------EIGQKMLEQ-LPRDSGITRVRNRCAITSRP--RGIVTRWRLSRIVWRSLADYNKLSGVQ-R-----AMW---------------------------------------------------------------------------------MMFKRIFTTVKPFMVDTFVHQQSPLKCS----------------------SIFNILGIQLRTYNPKVNIEWVPPPKV--------------------------------------------------------------------------SCLDPSKSGDRGTLPKLDLSRPQTRFTRKRTPAE--FADREDLSPEIKKINSL-EYAPLKKQIQAIKQDVLRTVQRH--------------------------PFDCASLESTIACLTIKIRN---QQRHTSAW----KRDKFSLVTCKENIERRNSLLKHLRAYDYKR--FEWLLEKLDLVYRPHPTTMEPVT--RKGSIMKLTTIYCDRMRNKRLDDYRKELEKEKLKFAEEKAQLEKWIEEEEQQLGLRK--------------------------------------------------------------------------------------------------------------------------------------------MASAIPTFTKIGKVIRLNKHGCT--NRPFYHIVVQ----KTR---DNFD-GPVIEQVGSYDAMPN-------SQHE---KLVAVNFERVQ--------YWLA-QGAGMSNPVAQLLGLSGFLPNHP----------------------------------QTLIQSWKNRREPPRERK----------------------------------------------LQPIKGIAPPLDNPKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAALQVSKLASVLARCLPS--DLKNA----AKFKVKVMEFDTHLN-MHFSKHVTVYAHDPSSVCKPGDVVMIDLLPKKLT--KN-ITHQVNKIVYTFGDIT-----------------------------------------------DPITG----KKVVVGK-----YRDEIEARNELYGKNPSGFDYTRAPDRGWQVGKRDFSDKDTYKKYHMFEHDEPYAV---------------------------------MALM----------------------------------QKILPCFHISSLYRTTMFPLLTVRHSTNYNASLQQE------------------------------------------------------------------------------------------------------------------------------------DDQPAQN----------LSNPY-----QKEKRCCVL---CKY---DVNVDY---KNARLLSQFLSPF--TGKVYERNITGLCKSKQK----IVESEIIKAQNAGYLAIMLKKVEYFKD-------PKLCDPDRPVRPHRY-----------------------------------------------------------------------------------------------------------------------------------------MMGQHAKFIARTVFVQNN-------------------------D--------IEQACRVINRIMGSEG-----------------------------WFDQFRR--------------------------------------------------------TRRYEK-------------PYM--------------------------ARRRINFE--------------------------KCKAIYNEDMNRKIQ--FVLRANRV-DP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPGC--------------------MATRAAMFTFSKFRYFPILKHRV---AKFSVSSNLLNASALEPGY------SRDPGEVFFKENVQTLLER-LTGRDC-DKVFHNR--------------KLGERLEPP-----------KYELLTQAEVDHVM-AEMEVKLKRKLQMPPLLKE---R-DPIKKIYSFNPELQGF--D--DSKY--VFINISQGITNRNREVVVRDPN-GVLREASWEERQRMCQIYFPVPGRKINVPKMFE-EGNIQNCL--DRDEFEFVLDRACAQFDPDDPEYISVTRKTYDF-VDE-----------------NTKYTSLRPTRHFGPMVLHLVLSKKMDN-LLFHFIN-TKDIDAAANLVRLFHTVA----------------------------------------------------DDTSPTEVDEFQLIENYIQGP-ALKKPALELAWQSFLEIEKQRREVHSQQNNASN-----------------------------------------------------MASSRLERIGSIYTRVRGLLRSGA---MKQEDKPIWYDVYEAFPP------KIEPFHGRKVPDI-------------------------------------AVRNILYPEDIIRAKFYERYG-----------------SSGQISLTNKYP--TPCQNFLDKYREM---EK-DYADENELFEAVVK---VLQEEKSMFSSNEQQS------------------RDTSMASMFTSVNKEISQKSKINIANVLSEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPFMKGPA-PIRRTLE-YLD----RNKL--VL-----KDRVKIFSI--NYN----TKGENHEGARQFVF---------------------------------WHLPQLQYKNPNIQ--IATFKNLTPSPFIRCYLENGEEVLMDVDFKSKDEI--YERVRRIICKSEETL-KAEDKIE----NP-ANFG--AKCSRHCICEVPGQLP--------------------CP-----------ALIP---LPNSWRGKY-------KFQKPDEL--------------------------------------------------------------------MFRIAPKKFIPADEKAEVKRLYDN---YFHQMK-SLRHYFFEQSLEQAESGEVAQMKHRL----EEEEHIRLMEENRLENEKTAKLREEKLK---------------------------------------------IQAEKTRENILASL--INKEEETRQYEIQIEAFLEKQKATPFIQAENIEKAIEEALANPVDFNFAIDLDGYVY----------RGRET--------------AIEKIPEEERERLRSN-----------------------------------------MAGKGLLLKCNLLGYRFQNLQRICLRTFLSDAYQCDAEWKGRLNNPLLEKLKNE-NFYGELMKKF-QKESKASAIDVDLFSTFVLNEL--HLDDLEAITQKFRRCPNTIHALPSTGHSVIRTYLEFKHTDSLLRMVDDRLNYGLFLDYYLSNLLMDSFLKQGNFRDAAKVAIQLMLQEEF-DH----PITSHLALYSCYCYLNNPQPDPWDP----QPKPKPVEPVEDVKVRVDYIREPFFDDHFDLTQPRHLIGKTLVGFGKHFLRQSPDSVAYTSILLGWTLFEKHDKIIQTLDTILG---SSSKPQLFKKELELCKKTVQ---------------------------ESTNLPE-------FFLDNFNNRVNQLETGGLVVPGNVND-ILKQRIKDAV---SKHENEDIQRQKEQYQLWEQQREQEIERQTQAIEHRKRLAILEAKKKELQEKEEQLYFFDNLDEWE----LRHEEKILQKEMLIKQQEGRGKKISSKLLRQAEEDAYFPPEIT-PN----MRQK------------------------------------------------------------------MSHKESNNKSLSGFGK------------AFTKFSKLTNKSSLDEPD------------VKFATLLRHSKLIQL--GDPQGKIVEGKIFQVVGN----DLYIDFGGKFHCVCSKPNA----NESE-FVRGSRVRLRLQELELSTKFLGASQELTLREADALLLGLARTSGRKAI-----------------------------------------------------------------------MMRYSRTCNIFRV-----------------------------------------WRRFSSISAESVPVTESIT-----------------------------NDIFRTNESNPVNH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R--------------------------VEHNSRFYSI---------SEPVKKQFFAGGGLPK------------------------------------------EYQSLSETLNGLCIMVRKPAIELIHYL---NKTNFD----------------APVLRYVLYGKTGVGKSLSLAHIVHYGS-SAGFVLVHVPWVPKWFQYVKV--ATP-SSVHANK---------YDQPIEAVEW---------LKHFSTQNGHL-LDKLELKTSNTYTWSKRE-VTAEGSP---LSELIDLGLNRAKY--------AT------GCIVALLDELKKAASS--K-------------QCRVLVVIDGFNSFFSRK-SNVIREDK--SMVLPSDFLLTDALLSLTRND--WNN-GAVVVSVDPSAHPPEL----RES----------------------PLPRYLL---------GK-------TGFEHLDPF--VP---------------IEVQNY-------NDKEFRSQIDYYIE-----------RNWLQQPKARTDNG-RAELSFT-SG--KHPYSLMRLVAPY-----------------MAFKLSVANEATKKSLISQCRRISSYFQPSESEYE------------SKPVY--PPI-----LDLSYEARKERKIEEI----------------AQNITKLGTVEEKLIELNAPK------------------YYGWWALNLYERVISYNALPFTQFATRTCL--VNELP-------SIYNDVDAIALK----SLPIIKDKLN-----DLLLQEFEYVSPRTNR--KGETKSEATESDRRSRNF--IPLLNRLLVNQLS-QHNEDLQTTEVDYEPRLEAFWSL-GGIEP--------GKILKNIREKNEKFHKGKADDPIDRPIQYYGSPRLSLRHNKPLPQL------LDRNSGLSVEGT--------VPSWN---------LDPRVM-G------------YKYKF---CRAVNVPGFW---P---GTETQHGYMSYL--SR------GYL-----KRRDEELSISDHQDA-LHVQAILHSFAWTLSQACYLGFGPYTELTYPLSTQTIITDGQNYSFSAYQLNTC-ALYNKHSGDANPH--RNVCFSTDEMKLY---------------DII-ENGQV---K--GFNDDVLKSLIKFYLIKPT-EPQV-NMRPYLSPE-LYIGNVSDTERRQKTEKNFKFLVSN---------------RPNHILKDEIHQWEKIYKIDHDTRPMEKKIRFFETGDPAPGMKRLDDFNPKYVPKHLR-NPPK-RSRRGRLPVQPSIKL-------------------------------------------MATALQNTRMLLRRTLSVKKNEILARNICFTSTLKSNKDEGTLKKDDEAKEVAAKNAKQKEAKAKLNMLLEAMSKESQKAFPAESELALATPKFVKKNKPLKTKLISTKID--------------------------------SEMLQAVENVSKTFSKENEELKKNLVAKLESITDESEVARLEPFKPDKQKT-------ADLNSLLNTLKVDVK---------------------------------------------KPKKKAPESHLAALKI---DNVYGADLSGIFRNANFKEESGTVSK-LTTWEMLYQKELELLAT-----QPPSNGFQQMILWTKQGKFWQFPIDNEQGLEEEAKVG----------FHEHVF-LEPYLNPW-C---------------PRRGPVRH-FMELVTVGLSKNPYLTVAQKKEHINW-FRNFFDAQ-RSILIETGAIPDVPSKSPPSLSA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAATKFYNYLKVVQSATPYAKRVEQL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSRIFGEVARPN--------------------TSAKSMRIVNMFSSQPIEQRADIK-NYYPRHVE-IHVLMRNLRNYGLFRDEHED------------------FKEEIKRLRELRGK-GKPK----------KGEGKRSKK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSAIVNLRVFRNFQQFVSI---------------------------------------------RPISNYPTSFRKNEEIQKVDGDDEFRSLD---------------------------------------------------------LSPNKSLNMRSYGRKVYKRAAVHPP------------------------------------------------RSNKM--------------------------------------------------------------PTDQDWPSV---------------------------------------------------------WPVAR----------------SFHPASV---------------------PLP---LHQG---------------------WVVPGATPPGK--------------------FANAELMKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNFLHLTPPAIERQCQALKK---FCTEWPKELNTNEKIENHF--PI-TITTSDYLHSSP-SLRDARARIVTLQLKLSSL-KLDSHAKDKLLRLVK--------------------ER--------YNPETDVLTIVSERCPLRKQNLDYAMYLLNVLISESWKTEPWENEKCEADM-EKYV--------WEGSQSQRTVEQLLQRMPDREKAMP---------------------EVIEQYARNVTRFHN------------------------E------GEDAEKISDYKESVKKLLGLQA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Drosophila_melanogaster --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLRKSFANLPR-FGQMCGLPRRLQSTQPEQS-VETEPEDIALVEQRI----------------------------------------------------------LKHPDYF--QVHNL-----------------------------------------------------------------------------------FTVRDLFNARVHYGHKEGSLDDRMRPYLFGSRLGHLIFDLDKTASHLRDALNFAAHIAFRDGIILFFNRNAMNSHLVERKAQEAGEFSHTRFWRGGIFTNAN------------VQFDAV-----------------------TRLPDLCIFLNTQNNVMAQ----HTAVRDAAKMAIPTIGIVDSNCNPNLITYPVPGNDDSPAAVELYCNLFKEAILRGK----------------RERR---------------------------------------------QLLGLPPLDESQPRRSRKTK------------------------------------------------------------------------------------MNFLKKLLPQVATEVQQL---SRSGFHTSSVCCRV-QSGRYRITTK--------RNRPLTYEMANPP--HFIG----------HRKSWNSWNTSTMKDALRPSQ-TAIEDVFIRKFVTGT---WH-ALVCS--EVIIKRQHNTIR-----IAA-------------------------LI--RQA------ITPRKMY------------------------------------------------------------------------------------------------------------------------------------------------FLIGYTEELLS------------------------YWMQCPVTLEL----------------QTVGD-KKDVVFKYI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSQTLIRRLFNQACSRNIFILNQSLLSSHEPILPGYIGLRNTSFFNKLPAEDI------------------------------WRGVTAVSNAGKKRGRGKGS-GKKVAKDLNKGQSI-----------------------------GFGKCGRIWPGLNSPLI-----------RGNELINQQKLNENLDR--------ENGILKLRDSMGSFKLMK----LNPIDRGWSGSKMPG----RSIGPPDPVG---DEEFVS-----FDTRVLENKIVFIMKGNMGRKRRYSVLSVTGNGNGLAGFATAKAP-EV-RTALRKSKNRAGQKLINISLCENRTIFHDFRTDFGKTKIFCFQKPDG----------------------------------------------------------------------YGLVCHRAIQTICKVIGIKDLYAK---IEGST-NIQNIAKAFFIG-L--------------------------------MTQRSYQYIANE-----------------TNSNIVQLQKTRNR-FIDVKGMP----FPNSTLTQNTQEID-------------------------------------------------------------------YMHFTLGNQIVLQRKGTVPFYVYSKGHDLHQF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKERFRNQVNVRLHKLVNAYD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPSYELALVLR-QLPRPE----LISVIRRTAESILDKGGIIRKL-E---NLGS-RALPH----KVSEHGVVH-REGTHFTIAFDTAPTKIADLK-----EEFGRDIDIIRRYIF-KVEEPEQKP---------------C-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLHEEM------------LPPAYRKDVQEIIAAAQKKQ----KKKFNYNS-GLDYYPFQK-------------------------------------------------------MSLLGRIAEKTSRLSCLR----------LM-----------S------------------------------------------------------VYPTH---YVEPIVQKYKQLE----------QKNDLSKLY---------------------HVPIKAAVNKSS-------------DTIFHDDTKHKMINYITKKGNSALAR--TLLSKTLELIKRT----------------------------------------------------------------------------QTEH-------MNLAKGEKTTINT------------NPETLL------KQAVENCRPLLQVTAIK--RGGVTYQV-PVPITTKRSYFLAMKWLLEAAREK---E-RKVSLPEKLAWEILDAAHGQG-----------------------------RVIKRKD------------------------------DLHR---LCESNRAYAHYRWS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALRVFGLNIVKNNRNLLQNACKSRA-P---MPCYMAAAPFATD-----------VTVQAAPAAVQKQRVSKAMRAYLKRATEH-DEF----MKTQHLEFQ----IGK-----RHLANM--------MGADAETF------------------------------------------TQEDIDEAISYLFPSGLYDQKARPAMKSP------E---------------------------------VVFPARKAAE------------------------------------------------------------FDE----------------------------TGRPFHSMF------------------------------------------------------------------------------------YTGKPNFFQLLHDIVEE------------------------TNK----------------------------------LADLEERMLRRGNKPD---EN--------Q-----------------K-LEIAGFQLLPKDQLEL-LLVESIADIEYSN---FTNSMDRLIASPYAYKS-KAFIERYMKPLM--DQSKQLEVPKPRIDE-----EGRQYITTYECLRKTAR---ADVTVRLPGTG---KISINGKDI-SYFEDENCREQLLFPLQFSELLGKVDVEAN-----------------VEGGGPS---GQAGAIRWGIAMSLRSFVDQEMIESM------------RLA-GLLTRDYRRRERKKFGQEGARRKYTWKKR---------------------------------------------------------------------------------MKMHMKHLDLYSQAIKTLRW---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TQPMRALSTVNTSSGVQGNLSPAAPAPEP---D--------------------------------------------KLY------------SKLEIELRGIDPAVLKSYTWFATTAAEHLGIEKGKCWSPRKAHHERMTLLKSVHIYKKHRVQYEVRTHFRYMNFHKLTGSTLDTFLEYIERNLPEGVALQASRTELQ------------------------------------------------------------------------------EIPEHLRQP------------------------PEQV---------------------------------------------------------------------------------MSLKSVFLSALRSITMPAVPLQTS-----------------------------------------------------RIHTSACWRKA------EDRKEMLAS------------------------------------------LPAKDEGTVGEKTV--------------------------------------------------------------DIDTLINRKAKFFPDAS-----------TANTLFNGIPFNELP------------------ICNIR--VSPNNTIISVTDHKG-VLRLIRSCGIEGFKNTRKGTNIAAQATAVTISGK-AIELGWK----TVRV--KVRGLGPGRMSAIKGLQMGG-----LNIVSITDNTHVSFN-PPRPRKQRSL----------------------------------------------MNFLRQSFGITKQLASQAIQCSYETAVRGM------------ASLQQMHRSG-PHIKTRP------------------------------------PRQPLDGK---------PFAKGVVLKTLIKKPKKPNSANRKCVLVRLS---TGKEMVAYIPGIGHNLQEHNIVLCRVGRLQDVPGVKLKAVRGVYDLAHVVKKSQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNSLARIGGFVCQSVQIA---------------------GCGLQQVRTK-------------------YADW---KMIRDVKRRKCVKENAVERLRVNSLRKNDILPPELR-----------EVADAEIAA-FPRDSSLVRVRERCALTSRP--RGVVHKYRLSRIVWRHLADYNKLSGVQ-R-----AMW------------------------------------------------------------------------------------------MNKLLNIAQAGHRQFVREY---------------------------------AFKSDLKIKWMRPEKI--------------------------------------------------------------------------ACYKPEKSGDLAKLPPLK-------ADELLPEYRD-CKELDKADESVKSLFKL-SNNASYLTTKFYRDEMVKEVQRH--------------------------AQDFGSMEAKLAKMTAVIRR---YQEHMDKH----PRDKMIKVRLKELIDKRKKFLKYLRRWDYPR--FEWILEKLDLVYKPPPTHFHWIT--RKESLQKLTDIYCENLKEERLEAYHKQLQAQQIPFLEEAIKKMQFVRQEQISCDVPVTVTEEKIADSKRQLEMLKELQQAEAAASSKKQNEDGFN-------------------------------------------------------------------------------------------------MSLSPASGIGRFYAKSAKIIRFVRLGCT--NRPFYHIVVM----ERR---KNQH-QPVIEQVGSFDPLPN-------DYNE---RLVALNTERIR--------YWLG-KGAHLSTPAAELLGIAGLLPIHP----------------------------------RTYMTAWRNRRTAAEAEA------------------------------------------------------SPEKAESTA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSRRGLLLMGQCMPC--IKQNA----SKIRIRRMELDKNLN-MYFKKDEFYFAHDPQKVCKTGDVVLIRELPERLT--RL-ITHNVEKVVYPLGDIT-----------------------------------------------DPLTG----KKVVVGN-----YREDIEMANQLFGKSEKAFDYEKAPPRGRLEGTKDFTHGETYIKYHEDGKDQPFAV----------------------------------------------------------------------MLKLGKFLAQNATLVNLVGRQQLGTVSRLYSAAPESS------------------------------------------------------------------------------------------------------------------------------------DLDLPID----------IKNPY-----EKDPQQCIL---CKH---SIEPHY---KNVKLLSQFQSPY--TGRIYGRHITGLCKRRQE----QVEQAILRAQQCLLMPGYHKDLDFLQD-------PKLFDPERPVRPHKY-------------------------------------------------------------------------------------------------------------------------------------------MRHVQFLARTVLVQNN-------------------------N--------VEEACRLLNRVLGKEE-----------------------------LLDQFRR--------------------------------------------------------TRFYEK-------------PYQ--------------------------VRRRINFE--------------------------KCKAIYNEDMNRKIQ--FVLRKNRA-EP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPGCS-------------------MHLLRSLRQLNGLQGVRQAIRQVSSAPTKPAA----------LQY------ERDPQPLFTDAETQRLLQS-MTQLNL-DKVYRKR----------------TVPDNSS-----------ETKFMSNEQLDNEF-QNLVVRAQQILQMPPIVQI---K-KDVERVIAKDTALKDF--A--NSKF--VFTDITFGRRQSERKVIVRDMD-GTLAYATLDTTKRMNQLYFPLEGRQSYTPRMFALEELLAKCL--AEHKYEFILDRLLVQYEPHEPEFHNISARVFEH-LNE-----------------SKEFDLLRSTRHFGPMAFFYAWHRCIDD-LLYDMIR-RDYLHNAVELIALSYKLHNIPVEYQATLTELGKLHATPAESALAELRSVFRRHDNKQNIEQEIHTAIGKTEHDFAADEISLKFIEQYIASEHALKKVQLELAVQTLKEVNREKLMLFQGLKKAHGVQAS-------------------------------------------------MAQSRLEKIGTIFTRVQGLLRGGA---MKTEDKPIWYDVYAAFPP------KLEPRFDRPAPEI-------------------------------------PVRQIFYAEDVVRAKLHKENKP----------------QETISLFDHRRS--TQSQQFVQIYQDLKGQ---GALDEQRIYETALD---LLAEQRQQARLETTPE-------------------ECLPEQDSESKSQLLSDFKEAVVSQQITSSPAPPAPKGKKEANVGINIDSLFKD--------------------------------------------------------------------------------------------------------------------------------------------------MPFMKGRE-PIRRTLK-YLN----AGKL--VL-----KDKVRIFSV--NYN----TYGAHHAGARDFVF---------------------------------WNIPQIQFKNPEVQ--VLTLKNMTPSPFVRCYFDDGRDMLIDLDSRNRNDI--IDHLVKVVGKTREQL-DAEERLKESKDNP-ANFG--YGCGRHCICEIPGQVP--------------------CP-----------GTVP---LPDHMRGKI-------LFAPK----------------MLRAGCQLLTQSTLPT------GKTVGNSFALEFVRWRRKPRW-----LPVAKSKMFRVPERKKQSEEERTELMRLHNQ---YKTQLR-SVRQFLREEVVRHEETSTADHIVLTPEQ--EEAEFQKCLDANAAWNAAIAKERDQRLA---------------------------------------------KKREEKVAYIQERLEAQQLREEERKEQANQRVLLEIERSKNYITRENLDAAIETALANPVDHNFAIDMAGNLY----------HGRST------------SQLPDATPEPNQQVLSN-------------------------------------------MLRSRISCALPPRRLVSYFSA----EFNKVAHEGPAKFAA-------------------------GSSHAVTSVDLDVFVNP----DNRPMDLVDRLLKLRKQKEAS--LVPLIPSVLVKQLLDSTNPQETISVLRNPIQYGLFVDQFSGCFLLDFLLHNGHAVESAQLATILVDRNLC-NN----ELLESLALQSFWSFAKEFKPFES------SQVQPPAKNVEVEKVRVKFIRN--YPDDASENTEEKKLGRAMVRLGSGEGSLKE--LKQNVALLGYVLTGQVPEASSFL--------ASNSAALHKETLLAAQSIVE--------------------------SLKLEGSE-------ELLKSLQEAVEKSSKSNAIQS------LLENSVKANV---QKFEPKLLADYGESYQEWAKKFEAAVQRQLDSQSVEERKATIQKTLSELEAKRQNLWFFENRDDID----IQIYKK---KVYYPKRWFGKKKKP------KAADTFYVPPTITHNG-----------MSLLQKLSRSGVPMASLTCRSRMPMVIRLI------------------SGNTEKPAEESTPAVNTETAEIGSSKGGFAR------------AFDKYTAPATPPQLPEDN------------QTFASLLRNSKLIDL--DNAEGKVVSGKIFHVVGD----DLYIDFGWKFHCVCSRPTR----NASD-YVRGARVRLRIKDLELSTKFLGSSKDITILEADCHLLGLLSTPTRQSTAKTTPKIEDIL-----------------------------------------------------------MKMIRNRFGSLSRVSAQL-------------------------------------QRHVQQMSTNAAASPAEGAT----------------------------ISEFRTAVSNPGEH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S--------------------------AMQVAKFYTI---------PAEQKKQIFTGGGLPK------------------------------------------QYEQQIKTFTEACLMVRNPALELLQYI---KDGDLT----------------KPVVRYVLYGENGTGKTLTMAHVLHYGA-LNDFLLVHVPWAPNWMKRPKE--ASN-AAGQEGM---------IDLPFDAAAW---------LVHFKTQNGPL-LQRLQLKTSKEYVWSKRE-STPAGSS---LIELVEHGIARIKY--------AS------ETTAALIAELKQLSTA--G-------------QCKVMVAIDGFNAFFHPV-TRIFSDNK--QLVTPDRVTLTQPFLDITNYD--WTN-GVCILSVDKIAMTEGH----MDS----------------------YMPRYLL---------GK-------EGFEHLDPF--VP---------------IHVENY-------TDKEFHSYISYYLD-----------RHWIN----KTPQGFEEQLKFM-SN--KNPYSLMQLVKAL----------------------MLKLNRVRHLRTTYKRCLSGQSQLQLNSTD------------AEPAY--PEI--QD---LSFKARKQKDAANW---------H-------EEIRQVPTVEEKMIKI-NMPR-----------------YYGFKVVDFNDSKIPYNALPLTQHYTRTVL--E-DLPSETDKKAQAKDSEQEQEQPSVDGLFKAARGDVI-----DALEFAHDYYKHLEKQ-HNSAESNPVERERILTQII--VEQLNRALLQSLS-EEYKHLDELDVDYNPRHEAFWAV-GGVDP--------PKNVQKSKKGRE-WQKDMANESVDRMVQYTGAPYLALRHRKQLTPW------KTEAESENLELSK---Q---LPRFK---------HDPRTL-G------------YSTKH---QHATNVPGYW---P--KGNENNFGLLSFQ--SR------AHL-----QIRPKSFGEQDQLEA-LHSLAIKSSYAWLLAQANYNGFNTYNELTYPMNTQTVITNGREWSFYEYQLNTL-LLHGTNV-AENPR--VNFCRGTKPLPLY---------------AEISASGKC---V--DFNDNALRHLLNFYANAPSIQRSIGEQQPYVA---SDVSAYENAEQRDFINKTFKYLASN---------------RPRHLELPEIYLWEKLYKIDNNNRAMEAKRRFFELDI-NPWQRTLDTHDKEYVPRAVRPDVPK-NKNRFKKTYYP-----------------------------------------------------MLAVRSSQRLGLRSLLPSAFKNVGLVNYSSSQSKNDDGYSSSDDEKPTKKKEEPVETAAQRLNRLLGTMQATDQLSASDFPRPGDANRKRREAQKQEAAAKNVLT----------------------------------AAKNIASMLGTSESDKKQTESELLAKLLGHGSESSSAATGENQTADVSGSPSGDKELNLSDIIVGMKIDRRQQPQ----------QVEQTRGEYVRRSLASRFKPQNRDGAYQRSQRQTKREAESFTGS------VNLYGGEPLGIF----KDTQLPISNDILSTWSQLSERELSLQAS-----HPPANYFEQMVLWTDQKKVWRFPINNEQDWEDEHNVD----------FSEHIF-LEQHLEDW-C---------------PSKGPIRH-FMELVCVGLSKNPYLTAQEKKDHIFW-FRDYFQAK-KDILRDLISKEPSKSISA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSHKYTELIKVGTQYARRMNYL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNRIFGEVART---------------------TNEKSMKVVRMFSEEPIHKRDYVI-NWYPRHVE-THLLMKNLRDYGLFRDEHQD------------------FKEEMKRLRKLRGK-APPK----------KGEGKRASKK-----------------------MAQKVIKYIGRT----TDFRG-----------------------------------NTLWELVSNLPNWGVGRLLIRNMFQ------------RY--PEPCYMRILKVQSVDEQPG---------------------------------------------------------------------------EIRKVRVTVEKTWRGVTQPKPVEIYSTSYKADYELVPQDQEAKYLNNKKK-VEP--VILPTKIELPPLLRELV---SEETGNPNPQ------------------------------------------------MKVHYKLTDNKMARLAKDGEKPTVNFALGVGQPKPVSAKLYEGLL---------MSSALTRLLERLPLKKQTAQSGI------------RVFSNQ-----------------------EQRQEIEDDEEFR-------------------------------------------------------------------------VLSLRTVKQQMQKRQQVRRDPITPP------------------------------------------------RTGRM--------------------------------------------------------------AVDQDWTAV---------------------------------------------------------WPGPR----------------SFHPASV---------------------PLP---LRQG---------------------FTERGAAAPSK--------------------FANAELMKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNFLHLTPPAIRQQCEAIKK---FCTPWPKGLETEAKWQRHF--PL-EVTTTDYCQSLP-TIRNPEARRVTITLKLSDL-KFDAHARDKFLRLVG--------------------DR--------YNKDTDLVTFVTDRCPQKKQNYDYALYLLTACYHESFVTEPWEATKSEADM-EVYL--------FERNQSKVSAEGILNWNAKKGAPKV---------------------VPSKSFAECVEKLIN------------------------E------GENEYNLGKYKEEVKKMLNIA--------------------------------------MVRPTLVA-----------------------------LAKRV-----PLIH-------------------------FR-KGGAGV---PGAQTANQKASS-----------QAAGGKKLAGGPAIED-----------------------------------YELPARFARKTIDPEEAAYINN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------G---------------------------------GIPN--------------------------- Helobdella_robusta -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALPTHMMKKGN-VTLTRFINGRALSTSTALK-PENVANTMDEKNVTVLNHLNP----------------------------------------------------LEHKDYF--NVRNS-----------------------------------------------------------------------------------FTLNDLFLNRVHYGHKSIVRNEYMKPFLFGNRLGIDIIDLDQTVQLLGDALNFTAHVAFRQGIIMFVTRSPQNITTVEQMAKDCGEYSHCRKWRLGTFTNST------------VQYGAT-----------------------TRLPDLCIFLSTLNDAFEQ----HTAVVESAKMNIPVIGIVDSNCDPRLITFPVPGNDDTPCAIKLYMSLFTDAIKKGK----------------HAHA-----------------------------------------------------SMNINVEAKNSN------------------------------------------------------------------------------MLSTRNLYKFKVNFSFLSQQCKKF--------STTTVLNKNVRTACKKVTPN--------RSQPLNYEQAQKP--SLIG----------LTKSWNSWNTSNLDGVTEFTAETTWEDVFIRKFVTGT---WI-NLFAS--EIIIKRRQNLII-----IAG-------------------------IV--TQD------AVPRKMY------------------------------------------------------------------------------------------------------------------------------------------------FLKGYTEELLS------------------------LLLKRPVKMEI----------------QTVSS-KKDVIFKWI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHLTLLRNNLLILKTLSIIYSLPVPASDL------------------------------WEGVVSVSNAGKKKGRGKRV-GRKKVTDLNRGQTI-----------------------------GAGRENMLWPGLNSPIL-----------KGKAIVSRQKLPPDPEK--------AQEIVRMRDQMSKVRYPA----LPPLLRGYSGSKFNG----QSVGPPDPVA---DYTFDD-----FDTRVLEFKTVCNMTGTLGRKMRFSAFVVTGNKNGVAGYGLGKAL-NA-KAAIRVAKNKAAQKLVYVPRFEDHTVYHNMFAQYHRSKIFIHKKERG----------------------------------------------------------------------YGLRCHRVLKTICDLLGIKDLHCK---VENSTKNVQSVTRAFFDA-V--------------------------------THQETHAELAER-----------------MGYHVVEMKKEEDY-FPRLIASP---------------------------------------------------------------------------------------------STPANKKPIEDEVEDLEVCACHAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IVEAFSLCF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPQYELSVIFK-ALGRMD----LSKAIKRTSETILNSGGVIRSF-D---NVGL-RKLPY----KMFKHGNRY-DEGNYYIIKFDCPPNIVPDLK-----AHFNLDLDIVRPKIL-RQEKEISRP----------CHHRPC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFGE--------------MNIDMRERLKDDLNKYIKKL----------------------------------------------------------------------------------------------------------------------S------------------------------------------------------RYGPI---YLEPTFRKENLPEFL--------EETDDRK-----------------------YRPIKAAQNEQT-------------SFATYNDLVLKFIRILLREGNKERAR--NLVHKTFENVKLT----------------------------------------------------------------------------QIER-----FNKAQTDFEKESIEL------------NPVNIF------NKAINNCKPLLNIKKIK--RGGVMYQV-PVPISPNSQVFFAMKWLIESANEK---D-RISRVWDKLAQELLDASNNEG-----------------------------KSVRKKQ------------------------------ELHR---LCEANRAYAHFRW---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRMYLERAQAH-NAF----MSEEIAEFE----MGR-----RHLANI--------MGLDPENI------------------------------------------TQDDIDKAIEYLLPSGLFVKKARPMLKHP------L---------------------------------EILPKQKAAQ------------------------------------------------------------FGL----------------------------DGRPYSSFF------------------------------------------------------------------------------------YTGKPTYVECLHNLSLK------------------------LVE----------------------------------LKKYEGDRITLGVKFD---QS--------Q-----------------Q-LKLTGSQWYDHNTMED-KFSEKLSEQEYNV---LISTLEHLSKLPYSYME-RVLIFQYRLDLKRQNLMLNLEKKAVQYDA-----KGKGFHE-DEGKRKTAM---AKVRLYEKGTG---IVTVNGRPFLDFFPRLADREQVLFPLQLTDKLCKVDIEAT-----------------VEHGGTS---GQAGAIRLALSKCLIQMVPSGMVEKL------------RLA-GLLTHDPRRLERQKPGQQGARRKYTWEKR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESD--------------------------------------------VLY------------KTITIELKGHELAVMKSYEQFLTMAANELDISICKVWSPPR-SIRRWTLLKSVHIYRKHMVQYETRTAYRVVQLKNLTGSTANTFLEYIQRNLPEGMAMKITRESIE------------------------------------------------------------------------------PLPDHL----------------------------------------------------------------------------------------------------------------MNMLTCICKNFANFRLSQLYSVQQR----------------------------------------------------FLHVTPPTEIL------NRSHRTKKD----------------------------------------IYKVAQEEKLHLISDP--------------------------------------------------------------LIDRGFTESGITIPTEN-----------TPSTTIDGVRFDKLP------------------IAHIK--SSPNNTIISITNHTGLELLGRSSCGQEGFRNVKKSTSVAAQATGLSVGLK-VMKKGVK----NLRV--CVKGIGAGRLPSLKGMQMAG-----LNIVSLTDTTPLIHS-GPRPRKARRL-MFSLSNLCKAFSSTSLLSSFSKNTVSHAIQKNVAPKSLVRRYCTFLNRTIPSKTINSNTALFNKANEVYIPQRTYESYSFVSELS--HFLKRRIKYGLPEFRRKR-------------------------------------IGATEGK---------PFIKGVVLKTLIKKPKKPNSANRKCVRVRLS---TGKEATAYVPGIGHNLQEHHIVLVKGGKTQDLPGVKLTCVRGAYDLGHVKKPK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QVRTR-------------------YINW---AMRRDVKRRALATEYAPLRMRLVALKRAKMLPEEIR-----------SHASQELTI-LPRDSCPNRTVNRCVLTSRP--RGVVQTHRLSRIMWRLLADYNKLSGVI-R-----AKW------------------------------------------------------------------------MWSGVLQRQYNGSMTFIAFLAFTIGRFHFKIPWLRVK----------------------VNSFEEDCRKMSFGFKLAVRFLLDSNC-----------------------------------------SIHKLSYSYLKNQIQNYEKEIEIPVVAHKRGNHTIQNGTTDIELKAVSDLSEEVVKVDLSCPRPGFDK-LKQYNEADDVIKKLFSL-EFSTKQVTLEKMMEEVVSMVQDH--------------------------PLDVKSMEVEIAKDTVAIRN---QIKHCLKF----RHDKYSISVLRNRISRRNDKLGELLSADKEK--FDWLTAKLQLKYTPPSKYSHLEKLSKRALRKKVARDFALQLVKEKNETLKKKLSEERIRFDKYKEEELDKIIKELKELDIDEVTSLADTLKALDREDLIPKKVEVPSRRQLLYSKKLEIYMKKKEEVDDQKLKANGFFTPREFPNIPDKLFF-----------------------------------------------------------------------------------IIRLALYGCT--NRPFYHVVVA----KHF---KPRD-DPGEEQLGTYDPMPN-------KNNQ---KLVSFNFQRLR--------YWLG-KGAKVSQPVEELLG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MANEIGRTVVGKVIKL-NSLWKA----AKVSVQRMKLDENTN-VYINWEKHCWASDPDSKANVGDFVLIKPLEKKER--LQ-IAHYLKEIIFPVGNIV-----------------------------------------------EPVTG----KRCRGTE---------------YIDEKNRNLS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVVS----------MENPF-----LKPAERCIL---CKH---DIPLDY---KNVRLLSQFTSPH--TGRIYDRGITGLCLFMQK----RIAKVIKRSRYFGYMPYEMKDPKYVTD-------PKLFDPFKRR-----------------------------------------------------------------------------------------------------------------------------------------------MAHHAKFFARTVLVRNN-------------------------D--------VDTAYKALDKILRNDK-----------------------------VLERARR--------------------------------------------------------NMYYEK-------------PYQ--------------------------LRKRVSLE--------------------------RCKRIYNSEMKRKIE--FVMKTFRP-SP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WIA-------------------------------------------------------------------------------FISPKVQMLLSK-ITGFNI-NKIFSPK---------------QVSVTESP-----------KYKLVTDEQLRELQ-EGSLKGANKLLQMPPYKKPWNIH-NNDELIISNDQQIAHFEMD--DSTY--VFTDISPGIPRRDRMLVVRDKE-GVLRRCNREESDKILMLYYPQEGKMYNMPQMFQ-PQQLEVLL--GKHQYEYVLNVACVQFEPDDPNYTRVTERTFEH-VLQ-----------------SGQFEVLRFTRFYGSMVFYFLIHNKIDL-LLAHQLS-QNRLDDAVSLVQLYHIIH-------------------------------------------PYCKSVAICKGEDAKDNYQLIQVSFF--------------------------------------------------------------------------------------------SQNGLLELQNLF-RVSGLLKSGV---LKDIDKPVWYDVMAAFPP------KIDPKYDRPVDEG-------------------------------------QVRDILYKEDIIRV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPFMHSRG-AVARTIE-YLR----KGEI--FL-----EPHIKIIMFAFNYDQKTKSSPPRHTGLYNFIY---------------------------------WHLPQLQFKNPDVQ--MITLNKITPLPWIKTYYENDSSLLIDCDGRSREDI--YNHVKRVLGMKQKDIASEEIEKEIERNRRVACFG--EESDRHCICELPGQVP--------------------CP-----------GWQP---LPKELTG---------IRKND----------------MWRNLLKTKFFSNCQNAIVNKDGNNNGKNILLSFVRH-RKPIW-----APLAATKLHRVVERKEIDVEEAEEMKVTSFCGDVFRFDLNYAFNLDLCSEYFKQENEAREILKVKSARVADEKDFKELVIKVNDEWNAESARIRKNLDE---------------------------------------------KEAVVKDEEYLELIDELNRKDAERNEIATALLEQANRERPNFITETNLDQAIEESLNKRTTHNFYIDLEGNRYCENPDGSVDMKPRNPTSGDFKSESETRDGRDEEEDGPVDGEIVGDNHDSEDVNNKVDSANDISKDSR------------------------------------------------------------------------------------------------------------------------------------STCHALMRTLKEQGDYERLFKILEDKINYGIFLDDYTCNLLLDHFIHNNLYKEALRIVSDIMLQENF-DH----VITRSLSYYACHQYIKNLPDI--------KINAPPKVPDVSVCQKVPYIENPWYDDHFDLYSDILKLGKSLVMLAGSYADV----VSRGYLVIGYLLYQKVDKALQVLKCYKE---KHDG---------------------------------------------------------LMLLEYHAVKNCLVNKGLVQKEDIIDKTLDQIVRDSI---SSEENNLIQNQKNIYDTWNKERNRLIEDRERQLKIKLKKDEIAKKLIDLTQKEEKLRFYEEKTNME----L---------KISEQPEFPKIKDV------VLEEQFVAPPGERKSMEGGKKKSR-----------------------------------------------------------------------------------------------------------------------------SFARLLKNSPFIQI--GDPNGAVVRGTIIETLDD----NLYIDFGGKFHCVCKKPRY----KTDM-YTRGTKVRLRLIDLELASKFMGSDKGISLLEADAVLLGIDRD---------------------------------------------------------------------------MRIRIFLELIKSASPRCHYGYTSKIKTNYKNI------------------------RPYSSIVSELKKALSGNDK-----------------------------RTLYWTSVDNPDQH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N--------------------------QRHESLFYTV---------PKNHFKQWLSKG-LET------------------------------------------HFYRSAKAFNEANIMIRKPALEVISCL---SKVDKS----------------FPLLKFILHGRNGCGKSTSLAHIIHYSG-AKGWMIVHVPWAAFYNRYSCSEIQYS-THSKTMR---------VDQPLAAAQW---------LADFKLQNEAL-LKNLNVLVSDTYVWNKRE-QTIPNSP---MLEMIDFGLTRVKY--------AT------DVMGVVLKELKLQCNA--G-------------KFKVLVAIDGYNAFYGD--TLIKQEDNRARKHKAEELSIVHFFKKLIVPD--WTN-GAVVCTVDGNASYPAK----PQS----------------------YLPIDLI---------GQ-------QGFEDLDPF--IP---------------VHVDNY-------SEKEFFSCMQYFFD-----------HKWFVNPYSQTEEG-IKEIKSL-SC--MNPKELYNLGVWM---MFKFSNTSLNFFCRKAVKTRIDSFISNPSRTLACNQQSQSLSTLANPTDPSVSDVSHVSQEEESLY--PPI--KP---KYPAGRWKNISEES---------AWKIHEISHSILQIPKAKERLEFLAGEDD-----------------RTLWLVAPLAPRP---NNLSYQKILTKSHI--MPDYP-------NLLKSVNVNGD-----ILSESMSLIDDLHHLESISVNHGYSKLSRTI--------NPNFDDQHLHNF--LVSSIKSLVAFLS-GKNEHLLRCEIDENVRVESFWRV-TGFEG--------DK--KSCDGSWDIVKTVNDIDAGVLQFQYRHNANLQIRTELPLNQF------VSMDDNTCIAQ---------DPYIP--------MHAPEFV-G------------IKSIK---DRPVNVSGHW---I---GSPCEFTTCSVHLMPS------QFV-----DKFLEYGSE-YLREA-EELMALTTMFGSCLAQAHNQGFCDMLDLTYPITTQSVIVNKEYVRFACYQLNTL-QMW--N--DANPL--QNLMWISEPVSML----------------SK-SSDNA---Q--TLSKQFVEFLLRSILIKPH-DREI-NLRPYLPDEESPV-------------KTKFTINFK---------------GEKPFEHPVIGRWQY----------------------------------------------------PKRSIYF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHEHKF-LDHHLSK--F---------------PEKGPVRH-FMELILVGLSKNPHMTIKEKISHIDW-FEDYFKNN-KSLF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAQTLSNYAKQIARL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SARIFGEVVRP---------------------TPSPMLKVVKIFSAKPLDKQPEFY-NYYPRHVE-LTSLMKRLRFLGLYRDEHLD------------------FKDEMKRLRALRGK-VKPK----------KGEGKRSQKKK---------------------MDPVKTVKFVGKT----LNFSG-----------------------------------KRLFDILCRLQNFGIGRIVYRNSFYE-----------RY--DEPCYIRITGVDP-DMSDPTQSSL---------------------------------------------------------------------NKRSESVAYGTQVFRG-ENMGEIK-IRNGAKADWRLVMKQDEEEFLRKANSVPKRVKTEPPKAVRFPPLLEQFLIQEANERGNVSEE---------------------------------------------GPLLQLKVRSHENNNINNNF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QISQP------------------------------------------------RYKFM--------------------------------------------------------------NANKDWFLT---------------------------------------------------------WPFPK----------------SFAWSYT---------------------PLP---VRMG---------------------YIKNNGIIPSK--------------------YGNAELMKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNFLHLTPNHIKLQCESIKR---FCTPWPKGLEKDDICRKFF--PL-SITVSDYLIDGPLSL-NEHSRNVLMKINLSSL-SLDKFSREKFVKLSR--------------------NY--------Y--KKDMLSLELSSCPTRKQNYDHGIFLLTALVTESKKRECWEAERCSNDI-DEYI--------WNFSKSKLNLEKIMKVF---------------------------------------------------------------------------------VFIYFFFIKTILST--------------------------------------MATSGIIKT-----------------------------VAKHI-----PLIK-------------------------FPNRLAAAA---MAATQQSKQP-------------SSSASAKTARGSGLPE-----------------------------------STLSMRFRRRPLDQVEIDYVLRIPRRFKKAFYSEMISANPDTAHPLAPDFSFHLTYDKNKVKIFHDTNCSCIYRIYMLPPFSSYLNKVDLLKPQDLKNLFLEITLDDVTTIYSLTEILEGEKGPFLSPVSSKNSKPLSGIGSYTPFCYAKSASIHYVDDNEYPTNLLNLTVSCVANELKCPIKQYTTVSYMKSSCLPDEQSTFSQLNKENFANLDYLVEYFKYPENYG-PHDDDGCNLVAKISVGKTKS--------- Homo_sapiens ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATSSAALPRILGAGARAPSRWLGFLGK--ATPRPARPSRRTLGSATALMIRESEDSTDFNDKILNEP------------------------------------------------------LKHSDFF--NVKEL-----------------------------------------------------------------------------------FSVRSLFDARVHLGHKAGCRHRFMEPYIFGSRLDHDIIDLEQTATHLQLALNFTAHMAYRKGIILFISRNRQFSYLIENMARDCGEYAHTRYFRGGMLTNAR------------LLFGPT-----------------------VRLPDLIIFLHTLNNIFEP----HVAVRDAAKMNIPTVGIVDTNCNPCLITYPVPGNDDSPLAVHLYCRLFQTAITRAK----------------EKRQ----------------------------------QVEALYRLQGQKEPGDQGPAHPPGADMSHSL----------------------------------------------------------------------------------MAASVCSGLLGPRVLSWSRELPCAWRALHTSPVCAKN-RAARVRVSK---------GDKPVTYEEAHAP--HYIA----------HRKGWLSLHTGNLDGEDHAAE-RTVEDVFLRKFMWGT---FP-GCLAD--QLVLKRRGNQLE-----ICA-------------------------VV--LRQ------LSPHKYY------------------------------------------------------------------------------------------------------------------------------------------------FLVGYSETLLS------------------------YFYKCPVRLHL----------------QTVPS---KVVYKYL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATAVRAVGCLPVLCSGTAGHLLGRQCSLNTLPAASILAWKSVLGNGHLSSLGTR--DTHPYASLSRALQTQCCISSPSHLMSQQYRPYSFFTKLTADEL------------------------------WKGALAETGAGAKKGRGKRT-KKKKRKDLNRGQII-----------------------------GEGRYGFLWPGLNVPLM-----------KNGAVQTIAQRSKEEQE------KVEADMIQQREEWDRKKKMK-----VKRERGWSGNSWGG----ISLGPPDPGPC--GETYED-----FDTRILEVRNVFTMTAKEGRKKSIRVLVAVGNGKGAAGFSIGKAT-DR-MDAFRKAKNRAVHHLHYIERYEDHTIFHDISLRFKRTHIKMKKQPKG----------------------------------------------------------------------YGLRCHRAIITICRLIGIKDMYAK---VSGSI-NMLSLTQGLFRG-L--------------------------------SRQETHQQLADK-----------------KGLHVVEIREECGP-LPIVVASP-------------------------------------------------------------------------------------------RGPLRKDPEPEDEVPDVKLDWEDVKT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQGMKRSVWSNLKRAAT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRYELALILK-AMQRPE----TAATLKRTIEALMDRGAIVRDL-E---NLGE-RALPY----RISAHSQQH-NRGGYFLVDFYAPTAAVESMV-----EHLSRDIDVIRGNIV-KHPLTQELK-------------ECE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIVPVP------------LAEKLYSTKKRKK---------------------------------------------------------------------MVAPAVKVARGWSGLALGVRRAVLQLPGLTQVR----------WS------------------------------------------------------------------RYSPE---FKDPLIDKEYYRKPVEEL-----TEEEKYVRELKK------------------TQLIKAAPAGKT-------------SSVFEDPVISKFTNMMMIGGNKVLAR--SLMIQTLEAVKRK----------------------------------------------------------------------------QFEK------YHAASAEEQATIER------------NPYTIF------HQALKNCEPMIGLVPIL--KGGRFYQV-PVPLPDRRRRFLAMKWMITECRDK--KH-QRTLMPEKLSHKLLEAFHNQG-----------------------------PVIKRSH------------------------------DLHK---MAEANRALAHYRWW-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAPCVSYGGAVSYRLLLWGRGSLAR-K---QGLWKTAAPELQT-----------NVRSQILRLRHTAFVIPKKNVPTSKRETYTEDF----IKKQIEEFN----IGK-----RHLANM--------MGEDPETF------------------------------------------TQEDIDRAIAYLFPSGLFEKRARPVMKHP------E---------------------------------QIFPRQRAIQ------------------------------------------------------------WGE----------------------------DGRPFHYLF------------------------------------------------------------------------------------YTGKQSYYSLMHDVYGM------------------------LLT----------------------------------LEKHQSHWQAKSLLPE---KT--------V-----------------T-RDVIGSRWLIKEELEE-MLVGKLSDLDYMQ---FIRLLEKLLTSQCGAAE-EEFVQRFRRSVT--LESKKQLIEPVQYDE-----QGMAFSK-SEGKRKTAK---AEAIVYKHGSG---RIKVNGIDYQLYFPITQDREQLMFPFHFVDRLGKHDVTCT-----------------VSGGGRS---AQAGAIRLAMAKALCSFVTEDEVEWM------------RQA-GLLTTDPRVRERKKPGQEGARRKFTWKKR-------------------------------------------------------------------MAARTAFGAVCRRLWQGLGNFSVNTSKGNTAKNG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLLLSTNMKWVQFSNLHVDVPKDLTKPVVTISDEP---D--------------------------------------------ILY------------KRLSVLVKGHDKAVLDSYEYFAVLAAKELGISI-KVHEPPR-KIERFTLLQSVHIYKKHRVQYEMRTLYRCLELEHLTGSTADVYLEYIQRNLPEGVAMEVTKTQLE------------------------------------------------------------------------------QLPEHIKEP------------------------IWETLSEEKEESKS-------------------------------------------------------------------MQAVRNAGSRFLRSW------------------------------------------------------------------TWPQTAGRVVA------RTPAGTICT----------------------------------------GARQLQDAAAKQKVEQ--------------------------------------------------------------NAAPSHTKFSIYPPIPGE----------ESSLRWAGKKFEEIP------------------IAHIK--ASHNNTQIQVVSASN-EPLAFASCGTEGFRNAKKGTGIAAQTAGIAAAAR-AKQKGVI----HIRV--VVKGLGPGRLSAMHGLIMGG-----LEVISITDNTPIPHN-GCRPRKARKL----------------------------------------------MSWSGLLHGLNTSLTCGPALVPRLWATCSM------------ATLNQMHRLG-PPKRPPR------------------------------------KLGPTEGR---------PQLKGVVLCTFTRKPKKPNSANRKCCRVRLS---TGREAVCFIPGEGHTLQEHQIVLVEGGRTQDLPGVKLTVVRGKYDCGHVQKK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAFMLGSLLRTFKQMVP---------------------SSASGQVRSH-------------------YVDW---RMWRDVKRRKMAYEYADERLRINSLRKNTILPKILQ-----------DVADEEIAA-LPRDSCPVRIRNRCVMTSRP--RGVKRRWRLSRIVFRHLADHGQLSGIQ-R-----ATW-------------------------------------------------------------------------------------MLRVAWRTLSLIRTRAVTQVLVPG-----------------------------LPGGGSAKFPFNQWGLQPRS---------------------------------------------------------------------------LLLQAARGYVVRKPAQSRLDDDPPPSTLLKDYQN-VPGIEKVDDVVKRLLSL-EMANKKEMLKIKQEQFMKKIVAN--------------------------PEDTRSLEARIIALSVKIRS---YEEHLEKH----RKDKAHKRYLLMSIDQRKKMLKNLRNTNYDV--FEKICWGLGIEYTFPPLYYRRAH--RRFVTKKALCIRVFQETQ-KLKKRRRALKAAAAAQKQAKRRNPDSPAKAIPKTLKDSQ---------------------------------------------------------------------------------------------------------------------------------------MVHLTTLLCKAYRGGHLTIRLALGGCT--NRPFYRIVAA----HNK---CPRD-GRFVEQLGSYDPLPN-------SHGE---KLVALNLDRIR--------HWIG-CGAHLSKPMEKLLGLAGFFPLHP----------------------------------MMITNAERLRRKRAREVL------------------------------------------------LASQKTDAEATDTEATET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSVVRSSVHARWIVGKVIGT--KMQKT----AKVRVTRLVLDPYLL-KYFNKRKTYFAHDALQQCTVGDIVLLRALPVPRA--KH-VKHELAEIVFKVGKVI-----------------------------------------------DPVTG----KPCAGTT---------------YLESPLSSETTQLSKNLEELNISSAQ-----------------------------------------------------------------------------------------MAAVVAVCGGLGRKKLTHLVTAAVSLTHPGTHTVLWRR--------------------------------------------------------------------------------------GCSQQVSS--------------------------------------NEDLPIS----------MENPY-----KEPLKKCIL---C-----GKHVDY---KNVQLLSQFVSPF--TGCIYGRHITGLCGKKQK----EITKAIKRAQIMGFMPVTYKDPAYLKD-------PKVCNIRYRE-----------------------------------------------------------------------------------------------------------------------------------------------MAKHLKFIARTVMVQEG-------------------------N--------VESAYRTLNRILTMDG-----------------------------LIEDIKH--------------------------------------------------------RRYYEK-------------PCR--------------------------RRQRESYE--------------------------RCRRIYNMEMARKIN--FLMRKNRA-DP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WQGC---MAPLGTTVLLWSLLRSSPGVERVCFRARIQPWHGGLLQPLPCSFEMGLPRRRFSSEAAESGS------PETKKPTFMDEEVQSILTK-MTGLNL-QKTFKPA----------------IQELKPP-----------TYKLMTQAQLEEAT-RQAVEAAKVRLKMPPVLEE---R-VPINDVLAEDKILEGT--E--TTKY--VFTDISYSIPHRERFIVVREPS-GTLRKASWEERDRMIQVYFPKEGRKILTPIIFK-EENLRTMY--SQDRHVDVLNLCFAQFEPDSTEYIKVHHKTYED-IDK-----------------RGKYDLLRSTRYFGGMVWYFVNNKKIDG-LLIDQIQ-RDLIDDATNLVQLYHVLH----------------------------------------------PDGQSAQGAKDQAAEGINLIKVFAKTE-AQKGAYIELTLQTYQEALSRHSAAS-------------------------------------------------------------MAGSRLETVGSIFSRTRDLVRAGV---L--KEKPLWFDVYDAFPP------LREPVFQRPRVRY--------------------------------GKAKAPIQDIWYHEDRIRAKFYSVYGSG---------------QRAFDLFNPNFK--STCQRFVEKYTEL---QKLGETDEEKLFVETGK---ALLAEGVILRRVGEARTQHGGSHVSRKSEHLSVRPQTALEENETQKEVPQDQHLEAPADQSKGLLPP------------------------------------------------------------------------------------------------------------------------------------------------------------------------MP-MKGRF-PIRRTLQ-YLS----QGNV--VF-----KDSVKVMTV--NYN----THGELGEGARKFVF---------------------------------FNIPQIQYKNPWVQ--IMMFKNMTPSPFLRFYLDSGEQVLVDVETKSNKEI--MEHIRKILGKNEETL-REEEEEKKQLSHP-ANFGPRKYCLRECICEVEGQVP--------------------CP-----------SLVP---LPKEMRGKY-------KAALKADAQD-----------MLRALSRLGAGTPCRPRAPLVLPARG------------RKTRH-----DPLAKSKIERVNMPPAVDPAEFFVLMERYQH---YRQTVR-ALRMEFVSEVQRKVHEARAGVLAERKALK-DAAEHRELMAWNQAENRRLHELRIARLR---------------------------------------------QEEREQEQRQALEQARKAEEVQAWAQRKEREVLQLQEEVKNFITRENLEARVEAALDSRKNYNWAITREGLVV----------RPQRR--------DS---------------------------------------------------------MAASIVRRGMLLARQVVLPQLSPAGK---RYLLSSAYVDSHKWEAREKEH----YCLA-DLASLMDKTF-ERKLPVSSLTISRLIDNISSRE--EIDHAEYYLYKFRHSPNCWYLRNWTIHTWIRQCLKYDAQDKALYTLVNKVQYGIFPDNFTFNLLMDSFIKKENYKDALSVVFEVMMQEAF-EV----PSTQLLSLYVLFHCL--------------AKKTDFSWEEERNFGASLLLPGLKQKNSVGFSSQ--LYGYALLGKVELQQGLRA--VYHNMPLI-WKP-GYLDRALQVMEKVAA---SPEDIKLCREALDVLGAVLKALTSADGASEEQSQN-DEDNQGSEKLVEQLDIEETEQSKLPQYLERFKALHSKLQALGKIESEGLLS-LTTQLVKEKL---STCEAEDIATYEQNLQQWHLDLVQLIQRE--QQQREQAKQEYQAQKAAKASA---------------------------------------------------------------------------MAALCRTRAVAAESHFLRVFLFFRPFRGVG-------------------------TESGSESGSSNAKEPKTRAGGFAS------------ALERHSELLQKVEPLQKGSPKNV-------ESFASMLRHSPLTQM--GPAKDKLVIGRIFHIVEN----DLYIDFGGKFHCVCRRPEV----DGEK-YQKGTRVRLRLLDLELTSRFLGATTDTTVLEANAVLLGIQESKDSRSKEEHHEK------------------------------------------------------------MMLKGITRLISRIHKLDPGRFLHMGT---------------------------------QARQSIAAHLDNQVPVESP-----------------------------RAISRTNENDPAKH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G--------------------------DQHEGQHYNI---------SPQDLETVFPHG-LPP------------------------------------------RFVMQVKTFSEACLMVRKPALELLHYL---KNTSFA----------------YPAIRYLLYGEKGTGKTLSLCHVIHFCA-KQDWLILHIPDAHLWVKNCRD--LLQ-SSYNKQR---------FDQPLEASTW---------LKNFKTTNERF-LN--QIKVQEKYVWNKRE-STEKGSP---LGEVVEQGITRVRN--------AT------DAVGIVLKELKRQSSL--G-------------MFHLLVAVDGINALWGR--TTLKREDK--SPIAPEELALVHNLRKMMKND--WHG-GAIVSALSQTGSLFKP----RKA----------------------YLPQELL---------GK-------EGFDALDPF--IP---------------ILVSNY-------NPKEFESCIQYYLE-----------NNWLQHEKAPTEEG-KKELLFL-SN--ANPSLLERHCAYL------------------------MAAARCWRPLLRGPRLSLHTAANAAATATETTSQDVAAT-PVARY--PPI--VASMTADSKAARLRRIERW---------Q-------ATVHAAESVDEKLRILTKMQ---------------------FMKYMVYPQTFALNADRWYQYFTKTVF--LSGLPPPPAEPEPEPEPEPEPAL-----DLAALRAVAC-----DCLLQEHFYLRRRRRV-------HRYEESEVISLPF--LDQLVSTLVGLLS-PHNPALAAAALDYRCPVHFYWVR-GEEII--------PRGHRRGRID-------------DLRYQIDDKPNNQIRISKQLAEF------VPLDYSVPIE----------IPTIK---------CKPDKLPL------------FKRQY---ENHIFVGSKT---A----DPCCYGHTQFHLLPD------KLR-----RERLLRQNCADQIEVVFRANAIASLFAWTGAQAMYQGFWSEADVTRPFVSQAVITDGKYFSFFCYQLNTL-ALTTQAD-QNNPR--KNICWGTQSKPLY---------------ETI-EDNDV---K--GFNDDVLLQIVHFLLNRPK--------------------------------EEKSQLLEN----------------------------------------------------------------------------------------------------------MFPRVSTFLPLRPLSRHPLSSGSPETSAAAIMLLTVRHGTVRYRSSALLARTKNNIQRYFGTNSVICSKKDKQSVRTEETSKETSESQDSEKENTKKDLLGIIKGMKVELSTVNVRTTKPPKRRPLKSLEATLGRLRRATEY----------------------APKKRIEPLSPELVAAASAVADSLPFDKQTTKSELLSQLQQHEEESRAQRDAKRPK------------ISFSNIISDMKVARSATAR-----------------VRSRPELRIQFDE----------GYDNYPGQEKTDDLKKR---KNIFTGKRLNIFDMMAVTKEAPETDTSPSLWDVEFAKQLATVNE-----QPLQNGFEELIQWTKEGKLWEFPINNEAGFDDDGSE-----------FHEHIF-LEKHLES--F---------------PKQGPIRH-FMELVTCGLSKNPYLSVKQKVEHIEW-FRNYFNEK-KDILKESNIQFN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSLSEYAFRMSRL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SARLFGEVTRP---------------------TNSKSMKVVKLFSELPLAKKKETY-DWYPNHHT-YAELMQTLRFLGLYRDEHQD------------------FMDEQKRLKKLRGE-EKPK----------KGEGKRAAKKKKKKKKK-----------MARKKVRPRLIAELARRVRALREQLNRPRDSQLYAVDYETLTRPFSGRRLPVRAWADVRRESRLLQLLGRLPLFGLGRLVTRKSWLW-----------QH--DEPCYWRLTRVRP-DYTAQ---------------------------------------------------------------------------NLDHGKAWGILTFKG-KTESEAREIEHVMYHDWRLVPKHEEEAFTAFTPA-PED----SLASVPYPPLLRAMIIAERQKNGDTSTE-------------------------------------------------EPMLNVQRIRMEPWDYPAKQE-DKGRAKGTPV-----------------------MAAAALPAWLSLQSRAR---------------------------------------------TLRAFSTAVYSAT-------------------------------------------------------------------------PVPTPSLPERTPGNERPPRRKALPP------------------------------------------------RTEKM--------------------------------------------------------------AVDQDWPSV---------------------------------------------------------YPVAA----------------PFKPSAV---------------------PLP---VRMG---------------------YPVKKGVPMAK--------------------EGNLELLKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNFLHLTPVAIKKHCEALKD---FCTEWPAALDSDEKCEKHF--PI-EIDSTDYVSSGP-SVRNPRARVVVLRVKLSSL-NLDDHAKKKLIKLVG--------------------ER--------YCKTTDVLTIKTDRCPLRRQNYDYAVYLLTVLYHESWNTEEWEKSKTEADM-EEYI--------WENSSSERNILETLLQMKAAEKNME------------INKEELLGTKEIEEYKKSVVSLKN------------------------E------EENENSISQYKESVKRLLNVT-------------------------------MMGSKMASASRVVQV-----------------------------VKPHT-----PLIR-------------------------FPDRRDNPK---PNVSEALRSAGLPS---------HSSVISQHSKGSKSPD----------LLMYQGPPDTAEII-----------KTLPQKYRRKLVSQEEMEFIQR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------G---------------------------------G-PE--------------------------- Hydra_magnipapillata ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSCKTSLKLFSRQVAR-VLNKKVHTSYGFVLNSQKI-SSIQGQKSL----------------------------------------------------------------LEQDDFF--DVKKL-----------------------------------------------------------------------------------VDLKKLFDSRVHLGHHEGTWNPLTRPYIYGQRSTQLIIDLNQTVECLNCALNVLSHIVYNQGIILFISMNPRFDYLIQKTARDCEEYFITHGWQKGLFTNSP------------LKLGT------------------------QKLPDLVIAFN-NSRFEKT----RDAIIEASMCNIPVIGIVDTDCDPRLITYPIPANDDTYDSVSHLCDIFKQAILNAK----------------LKRN--------------------------------------------------------------ELN--------------------------------------------------------------------------------------MLKVALGKVDFSLKHF--------GCTCSVRNIMRRPKTKLPDQ-----STKGTKLKRYEV--PP--HRIG----------VVKSWDSIHTGGLKGSYWAAE-RLADDIMIRNFIEGT---FY-ERITS--DVIIKRRLNTII-----ICF-------------------------FV--SGR-----ETNTAKLY------------------------------------------------------------------------------------------------------------------------------------------------FLKGFCEKLLE------------------------KMMGCLIKIEL----------------RTGPE--------FV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MACKMSLRIYSGLKLISKCLYSNTKCGHNFSAIGELCDYIRKPSYWVSKRYYVIGEYDKL-----------------------------------WQAVSS--------GKGKRGGKKRTAAKAIDGEFI-----------------------------KFGKANMQFPGLNAPLPI----------KDRERSEKKSTFPKSDR---------------------IKHAK----FDASLRGWSGTSWPG----RYAGSPETPN---KEPIED-----FKSIVIEVKKVSVTRGN-GKRKRTSAIVVVGNGKGAIGWAIGKAS-FA-ASAIRKAKNKAVNYLHYVPVHADKTIYHSIETKVNSTTIKFERKVPGKKFTVAHFNAEKIPRSTIYDIIKRVENDSGHKRVQGSGRVAKIMTPKRIKLLKAIFDHSDRVSMRQAGRKFGCSHSHIIKTLAKYTDIKSYTKQGKSVILDDESYFTLSHSTINGNSTYYSSNRDKTPPSVKYRNKRKFEPKRNGEETRLHEKTKDKMSSQNLTTLQTMFQSSAQVGMKGLNIEEFGNAINIAFGQTVGKKELENLFLKVDRNCDGKVDWEEFCSYVLFENEQLLTTNNENADSLFPKRAKELSHPHHDTIVMLGYLPTLGGFQKGTKNGIQNSLDVDTYDNTYGRYISVSKDGLFVFWNLDFQLQRVVHLSDSIGRKPQQMWVTDVACLSNVKKVAVSTTDRHILFYDCSGNNFDIQFIITGLDHCVFCMDYWYDASDLNHSCLLLGDANGSVSCITFTLATVGLFDFSIGKEKDNTQSNVRKISFQELVGNRHTNVGAITFHNLHKNWVRKVKYISILQCFISCANCAPSSLLLVDLQSNKIKTSFKIEKGVYTFDYDKENNVIVTGGLDCTVRLWNPYVGRSNTILVLGKKEKNLEKNNVNKNCSHSKPLCGALYNPLYNQVVSACHGSVINIWNVLTGENVLSVSNAHEGSEITAIMFDKTMKKLITGSANGVVKTWNFSNGDLVREIKALDGNEVTGLACPNQNLIVVGWNHRIQVYHESEDASIKILNSLHKDDILSIDSLETGVVVTSSYDGQKVLILKSREDKSKAVTILFSADKNVQAWSSKNNFLGHFDALDELNDGSIHAMISDSKNNLLFIGDSLGIIYIWDISDCFFIHSTTTVKEDKKKFEKNKPQICLKFRAHVKTIVSLDYIENTKNILSASTDCCVRLWSVTGVLLGTFGQMETFSTTENIFKQNLVLDFQSSSPAMTSKVFKAKRKGCVR----------------------MPRYELLLITR-ALERPQ----LKIVLQRTAANLFQQEAIIRKI-E---SMGQ-QELPY----RMKSNSVWH-THGNYFLFDAYIKLDKLPFIR-----KELSFDSDIIRQTFIKKLCDFDEEK------------ARIP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIYECT-----------TSYVLPYEDRKRN---------------------------------------------------------------------MALKLASKQKLPFYILYKTIFKKPILYNNIINLR----------HK------------------------------------------------------------------SYTEK----APSLFNKDEVNMLKKTNLPPNIIVTEASN-----------------------IEKNQAADSFYS-------------TSIFYDETVCKFVNCMMKDGKKAVSQ--KVMHDTFLAIKKI----------------------------------------------------------------------------QLEK--------YHKSIDSSNVEL------------DPLKIF------HGAIENVKPVLGTQNIK--KKGKSFKV-PYPLPLNRRRFLANKWLLESAKKL--PG-NNVRMSQKLSKTILDAYTNEG-----------------------------SAVQKKI------------------------------EFHK---QAEANRALAHYRWW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALGLNQLRLNNLLSTASWQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTAALIRCL-------------ASCPEDTLEEKDK---E--------------------------------------------RLV------------SLLTVKVRGADEAVLDSYTQFAQRAAKVLQLDTSGKIILPM-HIEKRTLLKSPHINKKHRVQYELRTHARMFQLRELTGDTADIYLEYIQRNIPEGVSMSVEQTELE------------------------------------------------------------------------------QLPSFLQRNL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFSTSATGKIV------TWFQKNNLN------------------------------------------KLFTTFNILNVKAV--------------------------------------------------------------TPKDVPVKKKSKFPT-------------SNLVTKPETEFSDLP------------------IVIVK--ATYNNTLCYLTDHKG-ITATWTSAGIEGFKNSKRGTNYAGKVAAESLAKK-ANDLGVN----KVRL--KVRGMGPGRMDAVKALASI------LDVVSITDTTPIPHN-GPRPKKQRRL------------------MTNLLKSFSRSLINSFVLLKQPASKAFFSLFPPQNVNLKKNLLLKTHFGPNLFQRRHL------------PSLNQIRFQK-PRTKKKR------------------------------------PKPKVPDSRRILYG---PQRKGICVKVVVRAPRKPNSAQRKCAVLRLN---DGKLITAYIPGEKANLQEHGVVLFRGGRVQDCPGIKYKIIRGVYDMN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKKPFSPVTTLRLAYYGCP--NRPFFHIVAT----KQR---IARN-RGYYEQVGTFDPLPN-------TRNE---KLISLNMDRIK--------YWLS-LNCSMSKPVTRLLALAGVLPLDQ----------------------------------YTLKLAEKNRESKKSKEH-------------------------------------------------------ADNINSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSVFLGQVVGT--KMLKT----VKVCVTSLKLHPVIL-QYWNTKKVYLAHDEHSLCKEGDMVLIKETR-KLS--KK-KRYTILDIVERMPQTQ--------------------------------------------MESSTQVG----QKVLQP-----------------------------------------------------------------------------------------------------------------------------------MNYQSIAKLFINSPKIKSFVPVQLFHQSSVVNKKKKYHDVYTTIHV----------------------------------------------------------------------------------------------------------------------------HKEKMKA----------LEARYERLDVEDRPTGCLL---CPHRNPEIELDY---KNVRLLSQFVSPH--TGKIYGSRITGLCPNKQR----ELAQNIRRARKVGLMPVTMKYFDYHSD-------PKLF-----------------------------------------------------------------------------------------------------------------------------------------------------MAHHA-FRARTVMVGPQ-------------------------G--------PIVAYQNLMKIMSVEG-----------------------------LTRQVQL--------------------------------------------------------QRRYEK-------------PTV--------------------------KRHRLAYE--------------------------KALYTYNTSMNAKIN--LLMRGHRTEYP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WS-------------MASSLCSRCSSVVKNVFGSNGFGIKKIIIKTRFYSTDFDVTRDVFKSTA--PDH------RGEKSTLFEREDVQDILKR-LTGFDL-NIIFK----------------PQKNTLELP-----------KYKVMTEKEIKMEE-EKAIAEGKKRLKMPNVMSK---R-KPIKTQLSINSELIDMDEN--GANY--LFTDISPSKDRNNRGVLVRENDTGILREGSWDERDRMEFMYWPQEGQHHEMFPMLQ-DEHLPTVF--EQKRHLDVLDLINLQCPPDAPDYIRVHERVYND-IEK-----------------HQLYDLLQSTRYYGGMVFFFVKNNKFHT-FLNFLLE-NERIPDAIDLIKLYSIIH------------------------------------------------------NVASNSDGINLLKEYLKDH----------KLYTHQFVNPDQFVQI------------------------------------------PTRPHILKLFSPCVIRKYKMVGSRHLQ-GTIITRVRHLLATGS---L--KTPPLWYDIVLRFPP---PKTSLLSLADEVQCDT-------------------------------------PIRKIVLPMDDVVREFYKAYPQARR-------------DPVSLLQDDIGILETKTDSFLKEYYKHIEKNV-THEEAIRISIESFS---NLISKRKEYEELKDDHQYDNEKIFNMNAVMDLFLERDKPL*Q*CFVYMHVIFLY*TKFHLYIF*CVICNYILF*TEFKTRETSHVSFKK--------------------------------------------------------------------------------------------------------------------------------------------------MA--KGKF-PFRRTIE-FLS----SGTI--IL-----QKRIQVISV--SF-----TTDNSGKGLRDFVL---------------------------------RDLPRLQFKNPTRQ--FVCFRNRHEFPQITFYYNDGGKQMIAVDNKPADEI--LKLVEVAGAAPHSEILKSEEVEYPGRLNP-ANFG--KYGHCFCICEKPGQVP--------------------CT-----------ARVC---MKKSVKW---------WQNKEKSTG------------P---------------------------------------------------------------------------------YKDAVA-AVVARFQRELAEEERIKNDILGEFAKREMEEREKVLNNMAIVAKSNEELRIKREADKK---------------------------------------------AKEEEKNLLEEENKLKETLKQKELYHKNRDIVLRLIEESKTFVNLENLDDKITFALENETYYNYAITPFGEKI----------ISQKP----------PGNLGVWKGPSPTAYIIGGIKPGSAEWKSAFENTERTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHCNKCRSLNFFLCKNLSS-----------------------------------------QLFFFCHYSTSSQKLIKEV-----------------------------DDGFTLCNVDPVKH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S--------------------------LKHVSQIYSI---------PKSIATDALSTA-IPK------------------------------------------RFGEVSRTIDDYGMLLRKPSLQIIDNL---NRNKND------------------VKKYLLYGHDGNGKAMSLLHIIHYCL-QNDWIIVHVPNGFRFIDGQTKTIVQP-STWNNTR---------YDQPIEAANW---------LNSFSKINYKF-LH--DLKTTQTYKWGKRE-TTEEGKS---LYDVVSQAAGRNIY--------AT------DAVGVLLKEIQNQN------------------KVHVLYAVNGLNAFFGK--TSHKYNGK---LVEVENLGLVNHFVKLLKDKNKLKK-GTYVTSITQTSQFSQKRV--DPQ----------------------NLPMLL----------GE-------KGFDFVQDF--EK---------------LEIDNY-------NDEEYEIMMNYYRY-----------KHWLT--RDLSVKL-REEVKFM-SQ--MNPNLVAKICAAL--------------------MWKSKSPICNFLPSNKSSRIICLRKVNI-----------------------TSV--TQNKSLEEVTTNHKKSRDI------------------PFLFLPHTVNKPYFV------------------------------HPSSTSVPNIFEKYKWLTKTVS--SIGLPETHSLTEEEPSSI----------FVREFERSLF-----QTVAYQKSYANKNLRR-------LIPERIDGLVFNFIRLSLLEGSLKSHLK-PENSYLY-----HNPVVETHWPR--NYKF----------------------------------YYSKFQPNCVLKTKNNFSIV------EAPKELTRSEVDS-------LPGP----------YDTYSMNV------------YPRPV---VHLNYRPGTD---L---HKYNNNRHCHTSIVFN---------------NRLKFDDQ-------MYTFGMFTMFAQLSAQALAEGVLHGTDLMKPLVTQCLVTNGHRVTFMLYQLNTM-NMMDDKGC-------WNRTWYTPVENMY-----DSSDSLPLVFETA-DRGEV---L-KGFNKNFCKMFTNIIRKETL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIAYARRMAIL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAKIFGHLPRP---------------------VSERSQKVIDYFKSQPL--GVMYG-DYYPPMKR-YNSLLRKLRFLGIYHDEHMD------------------FNEEMAHKRKVRGK-GPPK----------KGKVLFK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLN-----------------------------------------------------------------------------------------------------------------------------------------LETTDWSSV---------------------------------------------------------YCAAE----------------SYNPSVI---------------------PLP---IRMG------------------RPYHNRLGDVPPNA--------------------KGNVELLKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNFFHLTPPAIKKHCEALSA---YCTPWPIGIERTR--------PI-KITTINHVYAGP-SIRHPNSRMVKLEVSEIEV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRVRPR-----------------------------VRPRVRRRIQTILR-------------------------FKHGVCFLN---TNVKSRTPLIAFPKRPVIGNKDSHKNNSINLEASGLSPPNLLFSKKSTEKVFSAGHPTSVQTIYKSDGSLILITESLPLKYKRPLISNEEIEYIMR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------G---------------------------------G-PDC*ELLLMKSRRYFFN?VFK**IS*V*? Lottia_gigantea ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEEEPKE------------------------------------------------------------------FLDDDYF--GVRKL-----------------------------------------------------------------------------------VTVKSLFEVGAHLGHKTGCRDPYMAPFLFGTRFDLDIIDLEQTKVMMQDALNFAAHIAYRGGVILFASRYRQTLDIVEQTAKDCGEYAHCRYWRGGSFTNSN------------VIYKGA-----------------------TRLPDLCIFVSVLNSVFET----HTGVIDSAKLLIPTIGIVDTNCDPRIISYPIPANDDTPVAIKLYCELFKQAILAGK----------------EKKK-----------------------------------------------------------KDQLVN--------------------------------------------------------------------------------------------------LQRL---LRRGFQTSACSYLNTKAGVPKPSKG--------KIETLNYEEGLPP--YEIG----------VKKAWNSWNTTNLKDEGGASE-ILLDDMFIRKFMIGT---WH-NLIVS--EITIKRRFNIIT-----IGI-------------------------LL--NRK------FSPNQAY------------------------------------------------------------------------------------------------------------------------------------------------FLLGYTEELLS------------------------AWFKCPVKLEI----------------STVKNAQRDMFYRNC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M------------------------------WDALTTVSNPGRKRGRARHV--KGLRMDLNKGQRL-----------------------------GDGKVRMSWPGLNTATS-----------TGESRQIIQELEADPER------KAKLAGARMRRKMTS---RR----VPALQRGWSGNSLPG----TSIGPPDPIN---DYKFEG-----FDSRVLELKRVSNVTANLGKIYTTSAFVATGNGNGLAGYGIAKAA-NM-KAALRIAKNRAAQQLVFIERYNEATVYHNFHCQVNKSQIFVHKAAEG----------------------------------------------------------------------SGVKAHRCIKTLCQLIGITDLRTR---TEGSTRNIQNITKAFFNG-L--------------------------------IKQETHQQLAER-----------------MGLNVVEIRRG----VPTIVARP----QNRPSVKKEDKPKSTDL------------------------------------------------------------IF---ANLYFDGKVPLKKRIVEPFYHKMRPYKLKQF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLYKNRNQRQIQRERAVYGLE--PNKEERKIRCLPLK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPTYELALIVRAALERPQ----LANCLKRTCTYILDRGGVVRQM-E---NLGN-KNLPY----IISSHGHRH-TEGNYFTVDFDLSPNQMSTLR-----KVLLQDSDVVRPGIV-HKEEKFVRP--C-----VKNPENEC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFGELK------------NPDFEKRAWKKQILRRVQYKMKASRNK-------------------------------------------------------------------------MHPQSFLFSSVTQVR----------HR------------------------------------------------------------------RYDPR---FREPSLDTAELAEPL--------SDDDERK-----------------------YNPIKAAKNYET-------------TSVFYDPLLEKLINMLMYNGNKAAAR--EIVEGMLEEIKMI----------------------------------------------------------------------------QVKK-----YNHAGSKQEQEAIEC------------NPYLIF------QQALENLKPALMIIPVR--KGGTVYQV-PMSCPPKRQQFKVFKWLVDLNRDR---E-RKIRMSKKLAMDVVDAFHHEG-----------------------------KCMKKKI------------------------------ELLK---LCEANRAFAHYRW--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAASLGRIRHLCIKHCVARSLSANLKDSHVFLCSRKGFYTCSQV-----------WSGDVENKPVKAEKISKAMKSYMERAKAY-NDF----MQNEIEEYE----LGK-----RHLANI--------MGEDPDNF------------------------------------------TQADVDKAIAYLLPSGLFDKKARPIFKHP------Y---------------------------------EIFPARRASQ------------------------------------------------------------FGM----------------------------DGRPHHYLF------------------------------------------------------------------------------------YTGKPQFFEILHNISAK------------------------HTE----------------------------------LTEVEMTERGKVTEKK---------------------------------LNPARFQKLTKTALET-LTNETISPQHYLN---FCILMDRLITHPLARRA-EEFIVKYSKKLD--LGSQAVHRITPEKDE-----NGREYIR-ADGKRKSSR---ATVTVYDQGQG---DISVNGQDL-TYFSSMQDRNQLLFPLQVVDKIGQVDISCQ-----------------VKDGGLA---GQAGAIRIALAKALCSFVSDEDIGKL------------RLA-GLLTPDPRTKERKKTSQPKARKKVPWKRR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IQNPDQLD--------------------------------------------ILY------------KSILLELKCHDTGVIRSYQKFTEMVAKELDIEISKIYTPKR-DITRYAVLKSVHVFKKHKVLYEARTHYKMIELKHLTESTAETFLEYLQRNLPEGVAMKITKTRLE------------------------------------------------------------------------------RMPEHI-----------------------------------------------------------------------------------------------------------------MLRSVLRIASSQCSSLLFSS--------------------------------------------------------RIAATPASLKI------QNYSTSEEK---------------------------------------------VEESSEKTASP--------------------------------------------------------------ENVWSEADFGQTFPNKD-----------TASMLINDVPFCELP------------------IIHIK--ATSNNTILSVTDHKG-VVMYSETCGTVGFRNVKKGTNIAAQAAAISIAQKLARGKGIR----VVRI--NVKGFGAGRLASMTGFKMAG-----VTMVSITDSTKLPHC-GNKPKRKRRI---------------------------------------------------------------------------M------------STLNQMHRQR-ARKKKPQ------------------------------------KEGPLAGR---------PLLRGIVLKTLIKKPKKPNSANRKCVRLKLS---NGKEQTAYIPKEGHNLQEHSMVLVRGGRVADLPGVRLRCIRGKYDLGHVQK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWNQLNKLLRPVY----------------------QMVTPVRNQ-------------------HYDC---RTWRDMKRRKIVQKTFPVRQRLNSLRKNGIIPKELQ-----------EIADKEIKQ-MELNTCQSRLWPRCVLTSRP--RGLMDKWRVSRIVWRDQVDYNRMSGLK-R-----SCW------------------------------------------------------------------------------MYQQSFLACRCLSVGISTFAKNGSRCMVVMN-------------------------------INQQQNKLSLNYYATKAE-----------------------------------------------------------NKESKKDKTNQMVLRKPRNFDYSGDLTSTEIFP-------SSDIVNKYKK-ISELDSLPDPIKKLCTL-QYASRIEYKEHIINEMKDKIQRL--------------------------FGDRAFREQSIAKLTLDIRS---LIGHCLRN----PQDKLNKSILVEKIQQRRKYLKFMRREDYER--FEWLLEELQIQYIPVPRYHIPEG--KRNKRKSAAKAEAYAVRQKKIDDLKAKLEEEKHEFLNYKDKVMSEMKRDIETYKLDKDFFQKQLYREDERRMSKQTIRNRLESASAQSKK--------------------------------------------------------------------------------------------------------------MPRFKYRAFKLIRMRVQGCT--NRPFYEIVVT----PKD---NPRQ-GRPTEVLGFYEPLPN-------LNNE---KILAVNLKRVR--------YWMG-EGALLSQPLERLLGLSGFLPVHP----------------------------------IDYLDAFRNRKKLENVTE-----------------------------------------------------KGEDNVQSAS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDVRKCKIGDIVLLKKVPYNIT--PR-VSHIINDIIYPVGNVT-----------------------------------------------DPVTG----KRCRGID---------------YID---------------------------------------------------------------------------MFRVLGK--------------------------------QILKRPFGLLSYTEQTTCSSLVIHKKYGTKTLKYNV--------------------------------------------------------------------------------------SSLSEAGDVKLPSQYQDPNFDYKKVTFSPEDVEKLLKQME------SDEPLLT----------MEDPY-----AAKPRRCIL---CKY---NVDIDY---KNAQLLSQFVSPH--TGRIYGRRVTGLCIPMQK----RIAKLIKRARIFAFMPYLNKDVEFYED-------DKLVEYNKPSQKHF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHRVLREDK-----------------------------YLENVRR--------------------------------------------------------RKFNEK-------------PFI--------------------------TRQRISYE--------------------------RCKRIYSTDMQKKVN--FVMRKNRV-DP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WP-------------------------------------------------------------------------------VFRDEKVQEILKS-MTVTDILNRTTRKG-----------------QQLENP-----------TYFLMTDEELEELHAKRTSEVCKKIHSFVPFMEE---R-KSIDVTLEENPQLEAF--D--SSNL--AFIDISAGFINRDRFMTIREPS-GKLRKVDWEERDRLNFVVNPIKGRLVHPPIIFE-EKQLDEVL--NDGKVIYVLDRAVVQYEPDDPEFIRVTHRAYEF-INS-----------------ERLFDVIRATRHFGTLIFYLAWYKKIEY-LLIDMLQ-LNLIDDGENLVRLYSILH----------------------------------------------------------------------------------------------------------------------------------------------------------------MAGSRLEKIGTIFNRVNGLLRSGA---LDPAERPIWFDVYHRFPP------KVQPEYERPIPSQ-------------------------------------ELRQIVYPEDLIRLNFYKIYGD----------------SDVIDLKNESKK--TTCQLFVDKYIAL---LN-TAEDKEDLFMKTAE---TLKGQGVKLKNVNVKE----------------VQEETLEDTKEKNKPNFSVKDILGDIPKKKTEDQAKNIMFDNLGLE-------------------------------------------------------------------------------------------------------------------------------------------------------------MPFMKGSG-AIRRTLN-YLR----GGRI--HF-----KDNVQIVTL--NYN----VPSKTSKGISEFVY---------------------------------WHLSQLQFTHPYVQ--IVTFKNMTPTPFITLYFDNGERMLVDCDSRGKDEI--IEHLQRIAGRNT----DKSQRYDDGKTYTKNLIG--YGCSRYCICEVPGHVP--------------------CP-----------GWVP---LPKEMRGKH-------KYQKKDVEEAQ---------MASACVRTCNSLKSLNIVYPLSLRVCNSSVISVRW----RKPRW-----IPKTQSKLFYVRKPTPRDEEENKMLMQKYAN---YRTQMK-AIRSYFTKFVQEEKQARKEYDKSVGIEQ--ELAEVRLSIEVNAQWNQESANIREAREL---------------------------------------------AEAQKSAKIKAIKDQKQKEKDEEQIAELQSRIDNNIKFSEKFITQENMDEEIEKVLDSRKDFNFPINRKGQRL-------------------------------TRGKTKLKEDISSEPDA-------------------MAAHF-------------TKTLATRLKLIKISTRSLSFSAR---RCMLSEAYKCQDAWTQRLNSDYLQKVDLN-DFAVDLRSKF-D-KSKAMLVDMNVLANKLHEMEKGDALYMEDLIRKYRQSSVSVPVNDCIVYAIVRAYLDLGIADRLIDLMKNKSMYGIFPNPHAVNLIMDHFIKNKDYNASSQIAYEMMLQDDF-SH----PITYLLSLHSCVNHYNDISLDP-------PPEPEVNPDEEEDWIPVGIIRYIVYDDHFDIKDERFLMGKTLYTLGRNCAEDSI--LSQSLQFLGLGLYQKFEKGMNLLEKWAE---SKDNTLVAEEAVLKFEESLEKAETRNPEEPPKDLGLRTMADAVREFRITNEEKQ-------DYITRFKKLKSELSN--RIKEDSLET-RVETLVKNV----SKYEETDIKTQTELFSIWIEDRDRQIKQQIWEYKRQEKEKEIETKLKEIQTKEEMLRFFENRDRII----L--------SKRGIRPEVGEQEEL------DIDTIQAIRKKRR-------QFRT----------------------------------------------------------------------------------------------------PVVDEDT-----------------ESFSTLLRNSKLMQI--GSYKSRVVSGTIINIVED----DMYIDFGGKFHCVCKKPAVEDTRKGNS-YILGNKVKVRINDLEMTSKFLGADRHVTILEADATLIGIKHRYDTPS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LNNCSLMVRRPALEMIDYI---QHVDLN----------------KPVVKAFFYGRNGCGKSTSLSHVIHYCG-KAGFLIVNIRFPSALVQSYTG--YEA-STYKDGR---------IDHPKDAMEW---------LIQFQSQNSHL-LK--DLKISKDCIWNKRE-SSPAGTS---FSELVEFCINRNTY--------AS------DCVAILLREIKKLACD--K-------------KIKVLVSVDGINGLFRE--CVMRNENK--KLIMNEDITLIRSFRKIIQTN--WTN-GFIVGTIDELANEPGL----RGS----------------------YTPNFVL---------GK-------KGFECLDPF--IP---------------VLVTKY-------NTKEMYNCLQYYQD-----------YNWLQHPSSKTKKG-LDEIIFL-SD--YNPYTLTRVCGSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRK-------------------------------------------------------------------FSSEV---IEDMKL-----------------------------------------------------------GFAVANSFTWLLGQAYYQGFHHLCDITYPLATQTVLTDGKAFSFYAYQLNTI-ELGKQN--NCNPY--QNICWHKKEQNLY---------------EKV-EDGKV---I--GLNDNVCELILKVLLRKTQ-NRGI-NM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FEEHVF-LETEIKD--F---------------PRKGPIRH-FIELVAVGLSRNPHISAKSKRNHINW-FREYFKSK-SKVLEES---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASNYAKRMNRL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGRIFGEVTRP---------------------FKPGQQRIVRIFAEKPVHKKMEVM-EYYPRVNY-VNNLMKVLRNHGLYRDEHAD------------------LVEEYKERREARGK-VKPK----------KGEGKRSLKRKG-----------------------MTITRFIGRE----SHFRG-----------------------------------KTLYEIASNLKNFGEGRVVTRLAFHN-----------RY--PEKSFYRLTKVVP-NFTDT---------------------------------------------------------------------------DLRKGKAWGEKVFRG--DNCGVREINSGSKMDWKLIEREDEEEFCKLTEK-DKRSPTIVPKYADYPPLLGEWLQMDYRRTGLPLPK-----------------------------------------------PFKLKLKIEKSFTNKAVQE-------------------------------------MSNSKSLIPLCNAVHQRILSVRSLVI-------------------------------------PRKIRTYTESEEIEKKKPVGEFRVF-------------------------------------------------------------EIDGVVPRRDGDRPKRTIREKEIPP-----------------------------------------------PRYKSM--------------------------------------------------------------PIDQDWTRV---------------------------------------------------------WPTAA----------------SFNYSKI---------------------PFP---VRQG------------------YVHKNENSVSIPER--------------------YANIELRKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNFLHLTPAHVKKHCQAIKK---FCTPWPKVLNTDEKCHKLF--PI-TVKTREYCFSGS-TLSDERARIVTLQVKLSAL-KLDYHGEDKIKRLLG--------------------ER--------YNPVDDIITLTTNRCPLKKQNYDYAMYLLTACYYEANKTEPWELEKADEDL-DKYY--------WDRSQSKHNIVQLLHKVHLTDQGKNILDDVESTNPDEEFTEECLKTSDVAAYSEAVTDLHN------------------------E------GENIITINNYKNSVLNILNIRTDSKQ-----MITLSSTVDEESACTSFQTAQFSQNTAQLPERYIKKLIETGKGSVLNIGKSEESRERDLEAALNWIRQEI-----MLMKEQDKFLLKQFINLRTTILQLRCMYELHSSQSDVS---SIDGSTCSLSKVRSRYRRSDKHVVKPHVPSIKFGKSRSSTAIKYDSSSSTSSVSVSPSKSSASKTPQTVTNIEYDELPSKYRRKPISAEEMEYIEK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------G---------------------------------G-PV--------------------------- Mnemiopsis_leidyi ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLLRKCIRSVNNRSCLFNRLLSTDKTTDGTPSTQAEAPIAPLGAPGQPIATALSDQR-KEGKFVKSSKSLESVYRCD-DVIKNQEMLSNLSSLHSLVLSHHKALSKQTHRDRP--------------------------------------ITRNDFF--NVKSL-----------------------------------------------------------------------------------FTLRDLFESRVHLGHHIGCWNSANSKYLYGIRNNMHVIDIASTEQHLWRALDVLSHVAYSGGSVLFVNNRAGYGHIVQEAAASCTE---------GQWTDAG-------------ELGTFEQPDFSWFD--------------KNKPDLVIC-SSVNNPLSQ----KL-LLHANKHLVPSIGILDSDVDPTNLTYVIPGNDDSSQSILLYHRLFAKAVQRAK----------------LVKD--------------------------------------------------TLQNLDSTSRVKQAR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSRSPDSSPKISLYAHKSKSDETGYRIPLLQDDENQLFYSTDSDQWKF--------------------------------GIRSKAPMYRRRAQAKDIQPNINPQPIEHFNHK-----------------------------RFNKFQRQSIKNFSEFY-----------DYIPFHQLSDISLQRNH----------RIKDVKNLLRAERNAD--IYNSFSGRGWSHTSGCG----ESFGPPRKLLE--DGSLDVEYDTRFNSKILQMDYRQDLFSK-GKQSGMRVAVAVGNGKGLLGVGITFHP-RL-LEGLAEAKEYAYRQLVHFPMTEDGSIPYATRGRYHRTELHAIPIESH----------------------------------------------------------------------KENKGQRVVKELLDLAGYKNVAVK---LFGRN-PVESIVKAFFVT-F--------------------------------QNFESHQQQADR-----------------LGRYAVQFDPQTYF-MPKVLAKP--------------------------------------------------------------------------------------------------RDDSRPVPYSAEIHE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSQKFR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPRYEVVIASK-VLNKGD----YKTLLAKFCKVVWNEGGVVRGL-S---SLGT-RQFPHYQEATTESGKEKV-WKGTLFTMDAVMKESTIPKLT-----ELAEVESHAIFSKVA-PNPATFPLW--C-----KHRENQNA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNSAHL------------SNIRNFDSIIEDSDRVLEEDNT-------------------------------MLKNGQRAVKQVLSGFQARQIQTTCPNFEKKKAGKRGYWFKGKKKGTVQKPYRDVINGVQLP----------WETPFLRFSYLGQH------------------------------------------------------KYEWD---RTEPVRPWDRPELPKPHFGQYSRTAGDTINYTENCGYRVKVRDSSLVVEEDKQRTENHEMIFGDRSLERRVERRLAPYPSSFVDPLVWRFIEKIKLCKFTGVDRAFDIMVETMKLIKLH----------------------------------------------------------------------------QMQL---------KKANPDKEIEL------------DSNTIL------RKAVMNVSPPLRIDFVQVQKKRDGYKPCPVPLTVEESTNLAIKRFKIQSKRR--KR-RTPVEPMRLANLIIDSYNKRGVLREAVLEDAQLGEKYQDMYQRFGRVTYSHTTKKRLPYRQQTHLDEIMHVTLPLENDEYSKLPGQPEFHDDDLLDEEDKRDKPLRAGIGDFPSS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLNYATGLHRKQVTISWPIKKGHDFL-A--------------------------------------WNRMANWLLLEIKEQLEYHQS-----TKAHRLDYNTKVRTAK-----ENVAKI--------MGIDPEHF------------------------------------------SDSELKLSLLYLLPSDIQRREYKPHIPNELPVQSFL---------------------------------DIISQYDSTQ------------------------------------------------------------LQNTALRNSDFSLRKEIRLVHSIVVDALKQIDTSPGLELF------------------------------------------------------------------------------------I--DPDDVVLLSDNEID------------------------LDAPSDEAIFET-------------------------FDKIDSSDIEKETELL-------------NDPTENTNFDSHEESSLSE-LNEADIDLLPALRVFPFVPVQSGNDLENTTLQLQFNRLNHLIQD-RPDLI-KMYYPAIKHIVLDQTVLESNDSQIKTSQQ-----SRDSSVPVFRGKVNRIFLFHSVVTTLVPGSG---KITINDQSYLDFFPEVLSRMIVISPLRVSRTLGVFDINIE-----------------VDQENPEKVHSLAHCIAMSIADCIQMYSPE-LKKEL----------------EVVYRTEHRVEYKKAYKKNSRRRYKWRKR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVNKSPVVHGKHKDRYKRDLWNRVLILHDISGTTADVFLSYVQRNIPAG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAKNLLLNTIRILNAVVEHRIASLLLPYPPATPSLLTHCVSDYPQPSPENRIC------------ADLDARRDFGMLLSKRRQGDVFTAEWREEEDKGYWSRSNRDILVDKRLDFEAECPQWLVNKKGREWRPALPRFIEGVIVDLQTRKPKKPNSGNRKVARVQITKHGEKKVVTARIRGEKNTLQQHHRVLVQYARARNLPTVKWVIVRGQMDAQY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFTNSFPKVPHLVS-----------------------SLGPTR---------------------FSHKAVKKTIRNNYVRQAKRMHFFDRLQLETISESDLLPAKIK-----------AQAAADLKQ-YPRISHKNTETDKCALTGHI--LGCVNDYKINRKIFRDLAMKGNISGIKFWRYPNYSRWDKEKLAFRLIQLGHDSYYKKLTEELCEYDEEFKDVYTRRMIEENCDARTNDYVWCMRRNFTPDKWNDDYRF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSKWRGVFVSSKTGDLLNSIRIRLIRPTCR--NRPGYQMVACYGPGERTSYDDDRK-SSIIEEVGYFDDCVN-------SSGK---RICLINIAKIR--------QYIA-LGAEPTIPVWKLLGASGAFPVHP----------------------------------KVYAIAAENQYIQSILPQDSSSLRLEKFPNEKYPPYIDDQDGNDPEFEQYDPHEVDIDRGRSRRIRDYKAITEEDRDNREKGSIRTGDFKLLKNHIESIEESSLIQKRDLEHAFVKGFWDLNHYDQAGRGLHDNYKSTGSKQKLIETKKKQYGYWTRGVRDSGYTDPFKLRYRPQIHRQGENEELLEETKPQMDQTRKKEAQFSMARIEKHFTDLKEQLYKDRIAQVEKKIEEVKKGSAEEYLKPLRELTDEGEDKLLINETIKQLQCESVYNKFEAEKKSCKEQLEQDKLLLFNSVRDDIEDKITEVMNNRTPSNVDIDRWIENLGKRKKRTAGLSHSTPVRVKGPYVVYMLTDQDIVEDINFVKQVLQLKKSERRRTREHLNSVGSNDLRKAKFEDGKLYYEGQWFAIGSSVYIDKVGSSPLYKSGDMSLPGALDSRVPGGDSCNPFILQSEKNHEKQLVQLTALPFLAMTIPRSRLKWLVPHNTTSFFNPEKNPRFRDVPKVFPLAMKEKPKLRVYLGRVVRT--EYPRT----CVVQVENTEIHPEIR-RVYQHKHWVHVHDPEQECYIGDEVLVEPRNPPPGIQYHGKPYQVLKFLNRSEGYT-----------------------------------------------DHYNGTVWNRKQKPSS---------------YRSVKSSTKNRKIINRY----------------------------------------------------------------------------------------------------MICLRKLPAPPPIISLLRFKHGGGGDRDVYETPDKRRVFYNKQKRTSENLRMVKE-------------------------------------------------------------------LEVPNLNANSEKPGRGTIERFVPRIATTPVKKIAPNPDQIPTHKPFDKEEYVC----------QGNMM-----WKKSDGCVL---CNN---NITVTY---KDVAFLYQFVSN---TGMLLGPQTTGLCQLSHQ----IITDCIESARDLGLMAYDYKPLEYQKF-------GTIKDSLGVKDAGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAMNKAVRFAIWNSQRFAHSVSSESSEKVSHVKRNTATDRSFVEQNRQY------LHHPRSSVLSQKFHKTDKGFLKQLED-ARSTIKQEILAEIVDSSHQFSQTYSSQPTS-----------QIAFLTKDELNEAN-ENAKKRYAEILDSDPVPSL---IRPDISKTESNDSGLAWL--Y--ESPI--TFVDSSEDVSDQDRYIVTRNVN-GSLINNSHAERDVIHGSFFKKPGQIYPPFDFLESDQLFSELLSSDESDKLSMLDALPHCYSADHPTFQKRFNQITDAMLND-----------------TSLMDSMIHSRHFMPMVERALTNKHHDVSLLINHLHGTGRLKIAAEITSLLFFND-----------------PRTCKRTETFLAGQVMIINGKGLRIPLDRKRVSRTEENSVKASLLCDVDVDEIKSVEVVDTTPREKSLLVTLKNSSVAEALHNSGRGNRRFYNSEKFDFFPVKKSS--------------------------------------MSSKLVYFGNVITRTEALVKANV---IRE---PKWLKVCTRFPPLSEPVNPVLPDWENIEQTR----THRVGNFTRLDGHRFDPKEPTEYPRDKQVTHPHQPHHVYFSKDELRRQFYTKHPA----------------QHVQLTYSAECE--SPCERWMRGEEVVEGKVL-SLEEPDQEVWEVFE---EIRNNCDISDIDLQNT-------------------------------------------------------------------------MLSARTWKLERYAKQVKDWVHTIATPNDPVTLSVLNDHKLVVAQGTSKIHESLMLWESATWIKGVRKGAAILLMIKSPLSDSVRKIRFKFLPDSEGTAEEQAVECATCLNAYFKFEKEYTKEAFSQFQQEPIQGTDMVVHTVRRIGEP--QGMY-PYRRYLDHFLR----KRAM--LL-----HKKVAAVNV--VY-----SNHYSSETVKYFWNEFSPHLVYRNQETQIFKTSIGNGPTGIKVCFENGRV---------------------------VFLDGDKDF---VNPKPITQL--VEEFMKIAG--------CNDLEYKERTTP-QNTRSWTVPEAKCVCEIRGQCPCPKYVDLPMSVYSRFYEGGPSH-----------PFAPSVDMNDFPEGTTQ------IFSPAGKKHFMTYDKPKKY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTRGTVICRHNNTGSGTEQEFINKAKMRLDRINQYRTMSLRKNPLQ--------------------------------------------------------TTSSSKNFEELSKV--------------------DLSVDCVAGIL------------------------------------------------SKRYIGNHSNAAQQPSE---MQLQRDRSKNLDKVLSDVPDSSYFPEDVSPVNCQFTKELEMRDC------------------KGEDKLLKFPIDNEAVVWEESHVP----------FSDHIF-LNKYLVL--F---------------P---PVTHRFMETIITALQNNPDITI-DKKKQIIWSYLNYFDYH-SDLLEEDEEEILKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKRIDEGRGVLMATLVTVGHVPLEISNICYYFIIHGDEISGTVEDSKPRRSPIPSGGLEIKLNLTFKGLMTATSRISNAAMILPLILIVIPGTKCILPTGFTPTDNLRL--------------------------------------------------VTPSSSPSLKNCVEISPPTLPTGEESNRSEKFLVDGLDNCIDYCMFTSQCIAIAYSERANLNNRTCVLLYSEYVYPEDKRNVDIFVRKSCILVINSANRLKKEQLDGSEVSENGVEIVGRSSLYCLKFGKFDNETTVMTKRAKVFWTNCPAFGRWKFQSLASPHAYRISTFIRPTMCLE---------------------------FNEKARDVFLNECGDNVRQIFHLSNYGISKRQFRLIGTVPVSRVRVNRLRIPKTALKEVNFPVIYFLEGYEKPLSLKNLAWPDSTFLNPQKVPFFLPTTPVTVKCNDGFVLYGNEEAAKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNFLHLTPPMIKMHTAELKK---LCTPLPEKPKS----------CI-RQYTTNYVYPGS-SVKHPLSREASLRLNVKDL-ELGPETESYFRDLVSANQNIRLSDLHPKTYEHFRLPKILRDLPVLLELSGDILTIHAKQCPTRKQNLSLCYYRLSGFIQEAIDLTPIYKELVLDKLVTDFV--------FDQDDAKKIRFQEKNFVELDESDDG----------------GLLGLRGSQEAVESAEKVIT------------------------EITEDVVSEKFDIPEPYTRYVTVIVLLIVQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Monosiga_brevicollis ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-KQGPAWARTASRSMAQAAA-ATERPQPTA----------------------------------------------------------------QPHPATR------------------------------------------------------------------------------------------VTIDELFDARVHLGHKRGMWNPKMEPYIYTTLADSHIIDLNVTKAHLEHALELTRRISADGGVVLFVGGRPQFEGLIRHEARRCGEYFVTRKWIGGTLTNNTEARTSHRLVHGVQTLGG------------------------LRMPDLILF-FCVPV---S----KVGVKEALDCDIPSVGIIDTDGDPDGVTYVVPGNDDTTQAIEFYVRKFADAVLAGK----------------EAIS--------------------------------------------------------------DEQ-------------------------------------------------------------------------------------MKTKNQINIKNILLSNY--------YDLLQKNKLIFSSLEETEKD--------------NKQSAVK--YLLS--------------------GRLKGVSMARKFKLNGNSNIKNKSNKS---LN-KSTKL--NNTTKKSKSILN----------------------------------------------LPLYN--------------------------------------------------------------------------------------------------------------------------------------------------TNNSFNNSFLIKPSETSLNSVDSYRLQYVQKDIFTKWGIIGLKLWL----------------FNKS--------------MIKESQIKLKKEFNNSLNKIQNKNRRFNRQNM--------QSLKEEWKNQFIVKQSFKWLYGKN----NFLSLNESKKINNNNQLK-------------FSKNVKLQE-------------------------KQFKKISNFDSIETRIDVLICRLNWANTLHEARNLLKNNQINIYYNNKK---------------------INNHNTIIYLKKGLMLEYINSTNNHNNSS-------------WNLSYVLQFNENNSSYAVIIKN--------PTFKEHQEILNYWLKTAINETSNN---------------------------------------------------------------------------------------------------------------------KLSKNATKRLEKINHLITKYD--------------------------------------------KLKLF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQTKRVINMTRG-GRQSSMWALVIVGNKKGVAGFAIAKAE-DV-GDAVRKATAKAIRKAVFIDRFDERTIHHTIHHKFLRTKIFLRPKRPG----------------------------------------------------------------------GGLIAHRSVMGIAELAGIRDLGAD---IIGSN-NPLNVVRATFGA-L--------------------------------ARQIPATELAEA-----------------RG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAPSYELSLIYR-AMDKTQ----LAKTIRPLCEHLLQRGSIIRNV-Q---TENN-TDLPF----RMRAHFEYH-TQGRYAYLKFDASPEAMTSAL-----DLCRLDQNLIRYNVF-KQPDITKYS----------AGPRCK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMRKPT------------SAAAPKPAAAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MYDGKKTAAL--RVLQETFIIIKKA----------------------------------------------------------------------------KFDE-------ARQAALKQGLVVMTPSGAIPVPKPVNPMQVF------QDAIENVKPTVALTPVK--KSGSIHQV-PTPLTAKRRQSLAIKWIIGAARSR-----KKLLMPEALAAEIMEAANNTG-----------------------------AAVRKRI------------------------------ETHK---MAEANRALAHLRWQ------------MNELISKINNNTNYRKMLTC-QFNMDNYSILKVLKSEGVIKLLEINKNNKNQKIINFL--------INDKLG----KLGTNVF--------LKPISKPGRKVYISNKEILSMSNTKKGFTINTSKIGIKTLYSNLSEHKIYLLRTSSNNLQLLNNKGIITQEEAIKNNVGGELLLVVKFQ-----------------------MATSLRAMGSWGSLAAAGARMATLGAGVRQGGVG-MQVQVQVRGLAALALRP-----------TNVVRGCRCASTAGQSSQASAEPDLNRKQIDSL----LAQARTDAE-----RR-----ELISELYIVIHGAKNGVPVDAY---------------------------------------EQLSDDKLRRELRYLMPDPRVPNTAQALTRKPRF--------------------------------------ESLPDDHPLR-------------------------------------------------------------DP----------------------------TARPDSQAY------------------------------------------------------------------------------------FTGNSVYYDLLQNMDDM------------------------LEALDSEDARAADAAARAV------------------LSKKDQDIIDAKPDITAEAATTNEAASAESDKTAAQAHSEDGEEEPQSYIDRSDVTWLKRGELEA-MIGSPLRILQYRE---IISRLHRLRDHPLAYLI-ERQLSEFMRF----TSRSKPTDRKKIIDD-----LGRAYAT---GRRKDAV---ARVW-VWPGTG---QFKVNRRTLADYFGTDDAKVHALQPFAALNILGDYDIMCT-----------------VKGGGYT---GQAGAIRLGISRCLETLNPE-FRPIL------------KKG-GFLTRDARVVERKKPGQKKARRKFQWTETETDTKTETDTKTETETETETETETETETERQNELVWSV------------------------MAAAVATVFAGARASWLTSWSPLARALPMTMVAARAASTGGRSEKQAKNANQNKK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QQQQRSRRPRRDDKFDVTRYAAFAAEQQSAQSKGPKTIN-------------------------------------------EPQY------------RTCSIRMEGYNHAVLDSYVTFLERAARELGISCTGRIPLPT-HKRRETVLKSPHVYKQHRVQFDIATHARLFQMRNLSHSTLNTYLTYVQHHLPPGVATRVKLPVHVRERHREREETERETQRETESLSCFKILSRPAFCTTTMASPNNNDMAAHATTDEQIAQLFLENPVKPENKYARFMKENPFVPAFIGATGLCLAGGFVAYRNGNQSLSQTFQRGRVIFQGLTIASLIYGTWDIGLKKDDKPAQQQ----------------------------MRALQVVMRTALRFGSPVLAAGSVRGFAAARGPSVWSMRSWSGISAAANQAA--------------------------------------------------RLTRPQLSAAL------HTAQPVWAE---------------------------------EERPSDASQEPPAAAAPVEEAVPS-------------------------------------------------------------PEAAASSDSKTEQPETGKTANPTNQYNIAGMSEADAADWMRQVSLRQRRKSAEREEDLESCLAHVK--MTANNTIVTISRRDG-NSLNWASAGSCGFKGARRSTTYAAQVASQRAAEA-------------------------GDDSSQHASPCHA-----LARRLVIEVCAKCVF-SSKALDLRDR---------------------------------------------------------------------------M------------TTINQLSKKNIRKRKTRI------------------------------------TAGSKFLKNQGLIN---PQLKGVCIRVLTRKPKKPNSAQRKIAKVKLT---NGLIVDAFIPGEGHSLQEHGIVLIRGGRVKDLPGIKLKCVRGKYDLAGVIGRKTSRSKYGTKKPKTK-------MYETRFKKNLSLYRNLLK-IKGLGKFKIFNICQILGINPNIEYSKLSEHYIDELNLLLANIKKQDYNSILENVNIDNTNTRINNKNIDKNKLNLYLFNKNSTFNKSTKNIVLIEENLNDYESSQINTLIQINALRGRRIKMGYPSKGQRTRSNAITAKRINKRLIKK--------------------------------------------------------------------------------------------------------------------MNKIKLK-------------------FKTH---SLKLDFKKRTLYVNKENNHITYNALIKNQILPLSVKYNLLEKGSISYEFNDKNPLSLIP----TSHIRNKCLLTGRS--RGNLPKYGLSRIMFTELASEGLIPGMTVK-----NKI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPVALRLQRFGAR--HRPFFRIVAA----DQR---SPRD-GKHLERLGTYDPIPR-------ADGS---KVCSFDFARIRSVPALALQYFAR-LGARRSA-----LGARCFVPALL----------------------------------SSLFRLKTPRGIQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSCKGVCEKR--ERARM----VMLRADQQDTHPSHG-RSMKQRKKYLVHDELSARMPGDVVRIEECR-PLS--RR-KHFAIV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSRAIWKGVWKSNFM------------SNKNTRNITITPEDVNKNINIETGNSKKSVKINVTIKHIGHKTGEFAVSKIPAVY-KRKSKRK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNRLAISIRPVAALSSAVLASAGRSAPRTARQQVRHKGKVTTVKDHFRKLRAPKRHHGEALSSRDKFIYHLGTSANGRVGPAVVAVDSHGPHVVGP--------------PEAEGSFNK-----------QYIYMDDEQVDEYL-----ADVRRAFEFPVHEED--VALAPEAQVLGQDPEAG-------NNRFRFVFVDTSKGPSNTEREIRIRETD-GTLRTANSEERDQYLTEFVAGHKKSVRAPPMCR-EPALTRLI--GENQHRHLLDAVTATQYPYQKDYREVHARVYED-VET-----------------RKLYSLMQDTVHWPSFLLWLVDTEQTDG-LLTMLLS-AERLEDAVKLSILQTTGS-----------------------------------------------------VPETLTQQHMDSFKAFVDGRVSEFNKTHAARLLSAAASLKNASAAPAAPQA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSGNVLH-RLQ----QQVI--RL-----KPVITSIHC--NYK----LKGPGQAGARHFAR---------------------------------EHLPAIRFHNPQIA--TL---------------KKGDDALAAQLIVNETEI--IDVTGM------------------------------------------------------------------HS-----------NDIL-----QTLLERY-------GETTDAN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALRTSATRATAQSAALLLRSLNGPAFVPALSAAKQV---------------------------------CRQYSAAASVDSEKQTDAPQHH--------------------------ASLPSIASSDAGRH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S--------------------------LTDANSMYIM----------TEEHQKLLCTKIMKP------------------------------------------IRRRQVQEIKSCATLVRKDVMQALNQL---NKALDA----------------NQPCRVLFYGNDGLGKTSALGHILHHYY-CKSYAILPAFRTAQWYFEPNT--VDI-STTRPGD---------IDLNIDARFW---------LHTFNALNSEL-LG--QMTTTKEHTLSQDI-VLPQGTA---LSELSDMAQQNNRI--------AT------DLALIAINEL------------------------------------LENP-----------NRYGGLTVNMNEGLRTAIRNSQRLDK--------------------------------------------------------------GE-------NDLK--QPA--CA---------------VRMKNY-------TLEEVSSVIGFHSG-----------IGWTTLPNPAKDAHFAAELQLL-TD--FDPASISIMMRRH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPELWQHTADWLCKLGALSGEDPTFQKDATVYDLTVALQDGTVLCDAANALVPGCIPIVNRHPQQQFLRIQNIHAFLGALRNTFKMKEAHLFTADGLHNGGEMPQVVQCLATWANTPQAVKHGVKLGEATNTPNTALDADGRYDMYKSLKQLVEQNLSLRDAGTYTMSHSRPNSMVSDHQYYSEKVGTMKQVDELYYMIIYAGNTPALKLDEATDENIYGAGVTRDQKRSMVLDELFSTENSYIKVLQMLTGTYLPNLREAFSIIDIHLIFMNITEIMDAHNRFLADLSELMARTTGRMAGTCLLNHVTSFRIYGEYISMLPDAIDRLKVMRKKAPFQAALQAAQKASGQIFPLEDLLRVPMQRILKYPLMIKELLKSTPSDHPDLDKLRVANTAFQDLATYINESKRDRDNLLNIIQNVKKYKGKPIKDFGKLSRDGDLWVIDHVIGDKGKLRYVFLFDFGIIVCKHNKGSFKFKASVEFQHRQSVESVSDPAGEDGYPHRWRLMDTSGKKPVPLLTFGSYHEATKMRWMDMIRGKMLAVATPASPPPLRARMSLRAPNGASSSPKPRRSLSESAAVGSGLARPPSSPRPVLSPPIVGPRVPRNSVADDEAWFLPGAASLSESELKDLPDGTFLVRESTSRQGSYSLTVVFQNEVKHIKILRDGTQYRLTEHAEGFDTVQQLVAFFQRQNLGTYFPTLDTPLVMPYRSVMMQRALDTDSSDMLSGIGRARALFSYKATADDEISFDKGTELVLLNVVEEDDGWWRGRLPDGQRYHQLTAPPVLSILTGLRMCRLGWLGHVFHSPIIIHSKRSQTKVSDIRSPFNMMASQVKRLLSPAQLAAARSSVFGHIARP---------------------ANVRS--PVKYLQAKP--KAEAVM-NYYPDLLVKHESLWRRWYNMGIYYDEAMV------------------WRTDKMAWNKSRGR-FPVK----------KGEGKKKKKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MATKMMAAA-------------------------------------------------------------------------------------------------------------------------------------------ACSGVRGVVMGVGRRVSVSGLMVRA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAARCHM---------------------SVG---AKRG-------------------------GAVFPAV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSGVSFQLTGMQQTDDDISL---ERMKKPTNLVD----------PV-SFS----------SIRRSQCKVAQL--------GLEPPAAAILKEIAD--------------------NR--------YNANKDELRLVSSRYPSREMNRHHVQEVLKLLMLESMVDKQVRQNRSDFSLQGRGK--------YKPKPKAKARTITRQARSAIVHTTS----------AFKHKDRICRARVVQAATNFKHALDG------------------------I------RRRFPVCKVFENGDQEALKLRN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Mus_musculus ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAPAPAVLTRLLCAGVRRWPGFLQK-AIPGPAEQNGRKVTGAPVP-AVSEPQDGDDFQSRILDTP------------------------------------------------------LQHSDFF--NVKEL-----------------------------------------------------------------------------------FSVKSLFEARVHLGHKAGCRHRFMEPYIFGNRLGQDIIDLDQTALNLQLALNFTAHVAYRKGIILFVSRNRQFSHLIETTAQACGEYAHTRYFKGGLLTNAQ------------LLFGPS-----------------------VRLPDLIIFLHTLNNVFEP----HVAVRDAAKMNIPTVGIVDTNCNPCLITYPIPGNDDSPQAIQLFCKLFRTTINRAK----------------EKRR------------------------------------QMEALHRLQSPKGSEGSGTSPVPDKSHSP----------------------------------------------------------------------------------MAWSASVRGLGQRVLACSRELPGAWRTLHTSAVCAKN-RAARVRVAK---------GNKPVSYEEAHAP--HYIA----------HRKGWLSLHTGNLDGEDHAAE-RTLEDVFLRKFMMGT---FP-GCLAD--QIVLKRRANQVD-----ICA-------------------------LV--LRQ------LPAHKFY------------------------------------------------------------------------------------------------------------------------------------------------FLVGYSETLLS------------------------HFYKCPVRLHL----------------QTVPS---KVVYKYI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAAVRAAGCLPALCSLQAGHFLSRQLSLNAFPVAATSFLAVKTALSHGSLSSRETRRNHCLTSLSHVLQTQCCVSSPGNWTGQQCRPYSFFTKLTAEEL------------------------------WKGALAETGAGARKGRGKRT-KKKKRKDLNRGQII-----------------------------GEGRSGFLWPGLNVPLI-----------KSGVVQNIGQRSKEEQQ------KVEATMVEQREEWDRKRKIK-----VKRERGWSGNTWGG----VSIGPPDPGPN--GETYED-----FDTRILEVRNVFNMTAKEGRKKSVRVLVAVGNGNGAAGFAIGKAA-DR-GDAFRKAKNRAIHYLHYIERYEGHTIFHDISLRFKRTQIRMKKQPRG----------------------------------------------------------------------YGLRCHRAIITICRLIGIKDMYAR---VTGSM-NMLNLTRGLFHG-L--------------------------------ARQETHQHLADK-----------------KGLHVVEFREECGP-LPIVVASP-------------------------------------------------------------------------------------------HGALSKEPEPEPEVPDTKLDWQDVKA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQGLKRSVWFNLKRPAT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRYELALILK-AMRRPE----TAAALKRTIESLMDRGAIVRNL-E---SLGE-RALPY----RISSHSQQH-SRGGYFLVDFYAPTSAVENIL-----EHLARDIDVVRPNIV-KHPLTQEVK-------------ECD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIVPVP------------LEEKLYSTKRRKK---------------------------------------------------------------------MAAPALRAPLRWSGLALGVRCAVWNLPGLTQVR----------GS------------------------------------------------------------------RYAPE---FREPLIDKEYYRKPVAEL-----TEEEKYDQELKK------------------TQFIKAAAATET-------------SSVFADPVISKFTNMMMKGGNKVLAR--SLMAQTLEAVKRK----------------------------------------------------------------------------QFEK------YRAASAEEQATIER------------NPYRIF------HEALKNCEPVIGLVPIL--KGGHFYQV-PVPLADRRRRFLAMKWMITECREN--KP-RRTLMPEKLSHELLEAFHNRG-----------------------------PVIKRKH------------------------------NMHK---MAEANRALAHYRWW-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAPCVSCGRVLSPWFTPAVRASLCQ-R---PGYWTASAVGWQT-----------GTRFQLSKLIHTTVVTTKKNVQASRQESYTEDF----IKKQIEEFN----IGK-----RHLANM--------MGEDPETF------------------------------------------AEEDIDRAIAYLFPSGLFEKRARPMMKHP------E---------------------------------HIFPKQRATQ------------------------------------------------------------WGE----------------------------DGRPFHFLF------------------------------------------------------------------------------------YTGKQSYYSLMHDVYGK------------------------VMQ----------------------------------LEKHRGPLSASAE----------------------------------S-RDLIGSRWLIKEELEE-MLVETLSDEDYAQ---FIRLLEKLLTLPCGPAE-EEFVQRFRRSVT--IQSKKQLIEPVQYDE-----QGMAFST-SEGRRKSAT---AQAVVYEHGSG---KIHVNGVDYLIYFPITQDREQLMFPFHFLDRLERHDVTCT-----------------VSGGGRS---AQAGAIRLAMARALCSFVTEDEVEWM------------RQA-GLLTPDPRIRERKKPGQEGARRKFTWKKR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKWVPLSNLHVDVPKDVTRPTITTSDEP---D--------------------------------------------TLY------------KRLSILVKAHDRAVLDSYEYFAVLAAKELGISI-KVHEPPR-KIERFTLLKSVHIFKKHRVQYEMRTLYRCLELKHLTGSTASVYLEYIQRNLPEGVAMEVTKTQIQ------------------------------------------------------------------------------QLPEHIKEP------------------------MWETVPEEKKESKS-----------------------------------------------------------------------------MQVLRNSGSWLLL----------------------------------------------------------SWAGHGMTRFV------GIAPAKNIH-----------------------------------------TGAPRLEDSAARQNT--------------------------------------------------------------EREAAPSRFSLYPPVPGQ----------ESSLQWAGMKFEDVP------------------IAHIK--ATYNNTQIQVVSATN-ASLARASCGTEGFRNAKKGTGIAAQTAGIAAAAK-ATGKGVT----HIRV--VVKGMGPGRWSAIKGLTMGG-----LEVISITDNTPVPHN-GCRPRKARRL----------------------------------------------MSWPGLLYGLTTSLSRGLALAPQLWAARSM------------ATLNQMHRLG-PRKEPPK------------------------------------RLGPTEGR---------PQLKGVVLRTFIRKPKKPNSANRKCCRVRLS---TGKEAVCFIPGEGHTLQEHHVVLVEGGRTQDLPGVKLKVVRGKYDCGHVQKKK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAASVLGSLLRTFRQAVP---------------------PSASGQVRGY-------------------YVDW---RMLRDLKRRKMAYEYADERLRINSLRKNTILPKDLQ-----------EMAGDEIAA-LPRDSCPVRIRNRCVMTSRP--RGVKRRWRLSRIVFRHLADHGLLSGVQ-R-----AIW-------------------------------------------------------------------------------------MLRAAWRALSSVRAQAVTRAPVPA-----------------------------LRGGSSASLLSARCGLQPPS---------------------------------------------------------------------------LLRAARAYAAVQKPVQPKQDDEPPSSAFIKEYKDIIPNIEKVDDVVKRILSL-EMASRKEKLKIKQEQLMNKIVEN--------------------------PEDSRTLEAQIIALTVRIRN---YEEHMQKH----RKDKAHKRHLLMSIDRRKKLLKILRQTNYDV--FEKTCKELGVEYTLPPLHFQKVH--RRFLAKKALCIRVYQEVQKLKKQKRALKAAAAAAKKEKNEGVPENPSNAVPEKTQVN----------------------------------------------------------------------------------------------------------------------------------------MVQLTTIFCKAYHGGHLTIRLALGGCT--NRPFYRIVAA----HNK---CPRD-GRFVEQLGSYDPLPN-------SHGE---KLVALNLDRIR--------HWIG-CGAHLSKPMEKLLGLSGFFPLHP----------------------------------MMITNAERLRRRRAREVL------------------------------------------------LASQKAESEAKETEAS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSIVRSSVHAKWVVGKVIGT--AMIKT----AKVRATRLVLDPYLL-KYFNKRKTYFAHDALQQCSVGDIVLLRALPVPRS--KH-VKHELAEIIFKVGRVI-----------------------------------------------DPVTG----KPCAGTA---------------YLESPLSEPREELKVS---------------------------------------------------------------------------------------------------MAALVALCSGIGRKNLTTAAGCFTDRGTQAVSVIWRRC---------------------------------------------------------------------------------------------------------------------------FSQFEQVTSNEDLPVP----------MENPY-----KEPLKKCVL---C-----EKRVDY---KNVQLLSQFISPF--TGCIYGRHITGLCGKKQR----EITKAIKRAQKMGFMPVTYKDPAYLKD-------PRVCNIRYRE-----------------------------------------------------------------------------------------------------------------------------------------------MAKHLKFIARTVMVQEG-------------------------N--------VEGAYRTLNRILTTDG-----------------------------LTEVISR--------------------------------------------------------RRYYEK-------------PCR--------------------------RRQRESYE--------------------------TCRRIYNMEMARKIN--FLMRKNRA-DP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WLGC---MAAVRTPLSLWRFQLGSRRARRVCTRATAQRHPDALLATRPQPFEVGQPRRLLSSEAE-SGS------SEVKKPAFMDEEVQRILTK-ITGLDL-QKTFRPA----------------IQPLKPP-----------TYKLMTQAQLEEAT-RLAVEAAKVRLKMPPVLEE---R-KPINDVLAEDKILEGT--E--TNKY--VFTDISYNIPHRERFIVVREPS-GTLRKASWEERDRVIQIYFPKEGRRVLPPVIFK-DENLKTMY--SQDRHADVLNLCVAQFEPDSAEYIKVHHQTYED-IDR-----------------HGKYELLRSTRHFGGMAWYFVNKKKIDG-LLIDQIQ-RDLVDDATSLVQLYHMLH----------------------------------------------PDGQSAQEAKEQAAEGVDLIKVFAKTE-AQRGAYIELALQTYQEIVTSHSAAS-------------------------------------------------------------MAGSRLETVGSVFSRTRDLMRAGV---L--KEKPLWYDIYKAFPP------LREPVFRRPRLRY--------------------------------GKAKADIQDIFYQEDQIRAKFFATYGSG---------------QKAFDLFNPNFK--STCQRFVEKYTELQ--NL-GETDEEKLFVETGK---ALLAEGIILRRVREAR-------------TVSVRLQASSEGHEPQEDDDLAQRGQVKQEPETAPSPP------------------------------------------------------------------------------------------------------------------------------------------------------------------------MP-MKGRF-PIRRTLQ-YLG----RGDV--VF-----KESVKIMTV--NYN----TYGELGEGARKFVF---------------------------------FNIPQIQYKNPWVQ--IMMFKNMTPSPFLRFYLDSGEQVLVDVETKSNKEI--MEHIKKILGKKEETL-REEELEKQQRFHP-GNFGPRKYCLRECMCEVEGQVP--------------------CP-----------GLVP---LPKEMTGKY-------KAALKAST-------------MLRALNRLAARPETRPPTPLLLPVRG------------RKTRH-----DPPAKSKVGRVQTPPAVDPAEFFVLTERYRQ---YRETVR-ALRLEFTLEVRRKLHEARAGVLAERKAQQ-AITEHRELMAWNRDENRRMQELRIARLQ---------------------------------------------LEAQAQEVQKAEAQAQRAQEEQAWVQLKEQEVLKLQEEAKNFITRENLEARIEEALDSPKSYNWAVTKEGQVV----------RN----------------------------------------------------------------------MAAPMVRCGMLLARRLDASRLCLAGK---RCLLSAAYVDSHQWEAREKEE----YHLA-DLASLMDKAY-ERKLPVSSLSISRFVDNIASRE--DLDSAEYYLYKFRHSPNCWYLRDWTIHSWIRQCLKYGAQDKALYTLVNKVQYGIFPDNFTFNLLMDYFIKKGNYKDALSVVFEIMMQEAF-DV----PSTQFLSLYVLYRCL--------------AEKTELTWEEERDFGASLLLSGLKQRNTVGLSSQ--LYGYALLGKVELQRGVRA--VYHGMPLM-WTP-GYLDRALQVMERVAS---SPEDLKLGREVLDVLDGVLKVVTSPDVQTSEAQPQEGEDGLGSANLVEQLDTEEPEQSKLPRYLERFQASRSKLQELNRVESESLLT-LTTQLVKEKL---PACEAEDLATYEQKLREWHLERVQLIQRE--QEQREKAKQEYQALSAAEKAA---------------------------------------------------------------------------MAALCRSHAGTAGSRFLRALVFSKPLRNAS-------------------------TESGSESATHDSSAPRARSGGFAS------------ALERHSDLQRKAELRLESPKPV--------ESFASMLRHSPLTQL--GPAKDKLVIGRIFHIVED----DLYIDFGGKFHCVCKRPDV----DGEK-YQRGTRVRLRLLDLELTSRFLGGTTDTTILEADAVLLGLQEIRDSKSREEQPSK-------------------------------------------------------------MLTGITRLFSRVQKLDPRC---------------------------------------FLHMSVQATQNSQVPAERP-----------------------------RTVSRTSDSDPAKH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G--------------------------EQHEGQHYSI---------PLQDLKTVFPHG-LPP------------------------------------------RYMMQVKTFGEACLMVRKPALELLGYL---KNTNFA----------------HPAVRYLLYGEKGTGKTLSLCHAVHFCA-RHDWLILHIPDAHLWVKNCRE--LLQ-STHNKQR---------FDQPLEASTW---------LKNFKTTNERF-LS--QIKVQEKYVWNKRE-STEKGSP---LGEVVEQGLTRVRN--------AT------DAVGVVLKELKAQSAL--G-------------LFHLLVAVDGVNALWGR--TTLKKEDR--TLIAPEELSLVHNLRKMVKND--WHG-GAIVLSLSQTGSLFKS----RTA----------------------YLPHELL---------GK-------EGFNALEPF--LP---------------ILIPNY-------NPKEFESSFQYYLE-----------NNWLQHEKASTEEG-RKELRFL-SN--CNPEQLERLCASL------------------------MAAARYWKLVPRGRGLSQNAAAKASATAPEVRDLEVVAT-PVARY--PPI--VASMTADSKAARQRRVQRW---------Q-------ATVHAAPSVDEKIRILTKMQ---------------------FKKYVVHPQISALNADRWYQSFTKTVF--VSGLP-------PAPALSPPPPSL----DLAALRAAVC-----DCILQEQVYVRRRRPR-------SLFDRRQALASSI--LDQVVRTLVNLLA-PLNPVLSTAALDCKRSVDFYWLR-GEERI--------PAGHRKGHID-------------ALRYQINDKPHNQIRISKQLPEF------VPLDYSIPTE----------IPVMK---------CKPDKLPL------------FRRQY---ENSIFTGSKT---A----DPCCYGHTQFHLIPD------RLK-----RERLIRQNQAEQVEAVFRANAIASLFAWTGAQAMYQGFWSEADVTRPFVSQAVITDGKYFSFFCYQLNTL-ALTVQAD-QNNPR--KNLCWGSQSQPLY---------------ETV-EDNDV---K--GFDDGTLLQIVHFLLNKPR--------------------------------EDGAQLLAS---------------QEKELDLGP----------------------------------------------------------------------------------MLHRIPAFLRPRPFSGLPLSCGNRDV-----------SVAVLPAAQSGAVRTENNIQRHFCTSRSICSKKVDQSVPANEISQKAAESQGRGKETLKKDLLDIIKDMKVDLSTANVKTPKPRGRKPSASLEATVDRLQKAPED----------------------PPKKRNEFLSPELVAAASAVADSLPFDKQTTKSELLRQLQQHEEELRAQKDREKRR------------ISFTHIISNMKIAKSPSGR-----------------ASTRPQHQIQFDE----------DMDSSLKQEKPTDFRKR---KYLFKGKRLSIFADKAFADEPPEPEASPSLWEIEFAKQLASVAD-----QPFENGFEEMIQWTKEGKLWEFPVNNEAGLDDDGSE-----------FHEHIF-LDKYLED--F---------------PKQGPIRL-FMELVTCGLSKNPYLSVKQKVEHIEW-FRNYFNEK-RDILKENNIAFT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSPLSEYALRMSRL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SARIFGEVARS---------------------TDSKSMKVVSLFSEQPLAKKKETY-DWYPNHNT-YFALMGNLRFLGLYRDEHQD------------------FKDEQRRLKKLRGK-GKPR----------KGEGKRATKKK-----------------MARKKVRPRLIAELARRVRALREQRNQPRDSQLYALDYETLTRPHSGRRLPVRAWADVRRESRLLQLLARLPLFGLGRLVTRKSWLW-----------QH--DEPCYWRLTRVRP-DYTAQ---------------------------------------------------------------------------NLDHGRAWGILTFKG-KSEDTAREIEQVMYHDWRLVPKHEEEAFTAFTAK-PED----RLNSVPYPPLLRAMILAERQKNGDTSVQ-------------------------------------------------EPLLNLERTRMRPWDYPAKQE-TKGRAKGTPV-----------------------MAAAALQLRQSLCPG-----------------------------------------------PRVLRTFSSVAS--------------------------------------------------------------------------PAAPRAGPRTASRSERPMRRKALPP------------------------------------------------RTEKM--------------------------------------------------------------DTDQDWPSV---------------------------------------------------------YPTAA----------------PFKPSAV---------------------PLP---VRMG---------------------YPVKKGVPMAK--------------------EGNLELLKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNFLHLTPVAIKRHCAALKD---FCTEWPAALDSDEKCEEHF--PV-EIDTADYVSSGP-SIRNPKARAVTLRVKLSSL-NLDNHAKKKLIKLVG--------------------ER--------YCKATDVLTITTDRCPLKRQNYDYAVYLLTVLYHESWKTEDWENSKTEEDM-DEYV--------WAKSSSENSVLQTLLQMRAAESSVA------------PSREELLGTKEVEDYQKCVVRLKN------------------------E------GENEASLAQYKESVKRLLNLA--------------------------------MGSKMASATRVVQV-----------------------------VKPHA-----PLIK-------------------------FPNRRDKPK---LSASEALGSAALPS---------HSSAISQHSKGSTSPD----------LLMHQGPPDTAEII-----------KSLPQKYRRKPMSQEEMEFIQR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------G---------------------------------G-PE--------------------------- Nematostella_vectensis -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LNQQDFF--DVHQL-----------------------------------------------------------------------------------VSLRDLFVAGVHYGHHEGCWNPLMKPYLYGTREHFHIIDLNQTIKHFRLALDVLCHTVYRGGKVLFISCKPQFEELTQSLARDSGEYFVTQRWRGGTFTNSY------------MVLET------------------------RNLPDLVVFLH-VPSLGRN----ALAVKETAMCNIPSIGIVDSDCNPNLIMYPIPGNDDMPSAVQMYCRIFKSAVLTAK----------------EKR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PG--YRVA----------VTKGFESQHTGSLKGSYGASD-RLLDDVMIRKYIEGV---FY-DELDS--DIIVKRRDNRII-----ISF-------------------------LV--NRE------TDINKFY------------------------------------------------------------------------------------------------------------------------------------------------FLTSFSEKILS------------------------EAFGCIVKFEP----------------QAGA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAAYMLLRRACSSSGFRLISPLYAAQASAKASSLAPSFTVLSSLTREE-------------------------------YDKLWAAATGGRGTGRGRKK-KVKKGVDPEKLKFA--------------------------------RGGTQWEGFNAPVI-----------LEGDVVEKGRLPGKEDD-------------------QEFRRPG-----QWFERGWSGTTWPG----RKAGNPQRSD---REVLKN-----FDSVVVELRRVSNVTSG-GKKRSLRALVVVGNRNGAAGFGVGKGR-TP-ISAIRKARNKAVNYLYFVERCDNRTSF-------------------------------------------------------------------------------------------GLSCHRAIKEIAELLGIDDMRCK---VLGPT-TPLSLVQAVFQG-L--------------------------------TSQVL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPRYELIMIAR-VLTKEG----FSNILRQTCQSIISKGGVVRKI-E---NLGQ-QQLPY----RMRAHAEWH-TQGRYFLLDMDMNADHLELLK-----NELKMEPDIIRPSVV-KLQGRYDS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPYEHS------------MLECWQSYSKP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMWDGKKSLSQ--NIFTQAMQEIKKQ----------------------------------------------------------------------------QLEK--------QRSSSEPESITT------------DPTEIF------HQAIENVKPVVGCIPLR--KAGKVFQV-PSPLNPIRRRFFAIKWIIDAARDQ--SGPKNARMHKKLAKELLDAYNNEG-----------------------------TAIRKKQ------------------------------DLHK---RAEANRAFAHYRWW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVGNYY----YGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRRKSSV---ARV?-LAKGSG---KIIVNDRDFEEYFSRPTNCMIVRQPLTLTEHLDSFDIKVN-----------------VHGGGES---GQAGAIKHGITRALIDFNAD-LKPTL------------SKA-GFVTRDAREVERKKCGLRKARRRKQFSKR---------------------------------------------------------------------------MASRAICALLLENHHVASMTRCAVSP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSGAISRCLLGQRHYKKQRAGFATLADSEKGLPRK---E--------------------------------------------LEY------------SNILLKVEGQDAAVLDHYCQFVKSSGHVLGLKTTKQFNLPT-EAYKQVLANLPDSYKKHRVQYEFKKYGRMMQIKLLPVEQADIWLEYIQQNIPSGVNVHIELKTWQ---------------------------------------------------------------------------------DYVSPP------------------------DPRIEEQRRVEMLRKKGIFNKEKSE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQRVRKKVRKNISDG------------------IAHVH--ASFNNTIITITDRQG-NALSWASSGGQGFKGSRKSTPFAAQVASEVAGRA-AIEQGIK----NLDV--EIKGPGPGRESSVRALGALG-----IRITSIADVTPVPHN-GCRPQKRRRI---------------------------------------------------------------------------M------------PTLNQIRRQK-PRTKNMA------------------------------------IKKFVPPSEKVMLG---PQRKGVCVKVFIRKPKKPNSAQRKCALLKLS---NGKTISAYIPGERGQLQEHGVVIFEGGRVQDCPGIKYKIIRGKLDMN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSLKSFSTSAR----------------------QQKYYVKPN-------------------YLKK---WGRRDIKRREMFKDFEQQRSALRMIKKSDILPSGVR-----------KNAANEMKE-LPLNSSLTRIRNRCVMTDRG--RGIVGRFRVSRMMFRYFAERGQIAGVK-K-----AQW-----------------------------------------------------------------------------------MIEYSWAWTRHVAYLTGGDTEFKQVY----------------------------------EKTFLTHEWSLYLLL--------------------------------------------------------------------DTLDDLTTTDSSMGRKWI------------------CGYEN-IKELEAAPENVKRIFSL-ENANRFEKRKVEEQEVKNNYEGY--------------------------------SQRSVAELTLKINT---LERHMKER----PKDKHNKVFLHWLTDQRKKKLKHLKNKDFPG--YLQLLQELNIPELESPH--------SKWNKYKFRKFKIGVEVKEKRSFLDRKIIT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKKSIVALRLALYGCK--NRPFFYLVAS----HRK---KARN-RGYFEQIGTYDPLPN-------DRNE---KLISLNVDRIK--------YWLS-VGAEPTRPVAMLLGLAGILPVHP----------------------------------HSIEIASRNRDAIAKGEA---------------------------------------------------SATDVEKMGEEEKEK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAACVGRLSLLRF-------------------------GGERLPFMPKPTAMSAVRQMHITPPVFEGKYHYLER---------------------------------------------------------------------------------------------------------------------KRKLRKEREQELMARYEAFW------------LGMRLDE---EDRPTGCLL---CPKRT-DVTIDY---KNVRLLSQFISSH--SGRIYNRRVTGLCDKKQK----EITNAIKRARAIGLMPVTMKHPEFHND-------PKLF------------------------------------------------------------------------------------------------------------------------------------------------------MAHHSFLARTIMVAEKS------------------------G--------VSGAIRALRNVMAQEK-----------------------------HLKDIQL--------------------------------------------------------KRRYEK-------------PTI--------------------------KRRRKTYE--------------------------SSLRLYNSEMQRKVD--FIMKGQRRETP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WT--------------------------------------------------------------------------------FNDESVNTILRR-LTGCDV-EKIFSNR----------------KQALEVH-----------AYQLMTDEELLAAE-EDAESRARSMLEMPPVMEE---R-EEINEVIGTDERLAGY--D--SANL--IFTDISMSATDRTRNIVVREPD-GRLRKANWSERDRMNFIYFPKEGRKWKMPEMLT-ESGL------------------------------QVHQHVYDD-INA-----------------NSKFELLRSTRHFGGLLYYLTRLRKLDN-LLDELTD-SGRFQDAIDVVSLHHILH----------------------------------------------PHLETAVQAQEAKLSDMDLLLVS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MP--KGKF-PFRRTLE-FLS----AGRV--VL-----KKDVRSVML--SY-----THKYESKGLRNFIY---------------------------------KDLPQIQYKNNAVQ--FITAKDRTDFPTVDIFYGDGKKVMVDVENKKAPEI--LEIFSKVAGATESELQIRRQPKYLGRINP-ANFG--KYGHMYCICEIPGQAP--------------------CP-----------SRVP---HPEARKTKV-------WQEKDS-----------------MAATMMNRFRPSMLNLPFRYGVCLSHRAFS------AAAEA-----AETSAPDRKTIREAKKMNREKGMEIQ---SA---YKSRVN-DVVSTFREERIEQMRLRQAAEGEQQKLLEREKIAEKRIIEGVEAENAMLADLRSGHLTSSIYFFQLTSGLDKISQISRKIYVPLTNVHSVRTENQPLPVLPPVSAAYSVNQKMALIDKVSATETRLDTSATSDSQTSEEEESKEFITPDNLDEKIAYALENETNYNFALTPEGKKL----------HSTRP-----------PGNANMDMPGPAAFVLSPNRKDLTAAAENLLQENDSET-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAATLGRISLDRVFSAVKRP------------------------------------------------------------------------ILGRLYNAKANDV-----------------ENFDELLRNSQFVKL--GRPAGKRLKGRVMHVVARDKAQDVYADFGWKFHAVETHPLH----KN---FNVGDDVEVTLKTLEATGHFLGQSKRITLCEAEAKLTPLKKDSKVQEKTPK---------------------------------------------------------------MAAARGLLKTSSRGAFSLKIRASCPTRSYATAAPAARRQDERSSVIITENDPDKHLNSHQEFFYSVPQESFDNLLTHVLPKRFLKQRASCPTRSYATAAPAARRQDERSSVIITENDPDKH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L--------------------------NSHQGFFYSV---------PQESLDNILTHV-LPK------------------------------------------RFLKQSEILGGSYLMVRNPALSVIKKL---KKQGNS----------------QAPTRFVLHGDAGCGKTLTLSHIVHYAT-SAGWFVLLVPSVFSWVHSKRG--IQM-SKSREDR---------FDQPEEAASW---------LRTIRAINGPF-LA--NMQASQQYEWGKLD-STKKGEP---LISVIDQGLKRINY--------AP------DAVGVVLKEIKQEP------------------GLKILYAADEYNGFFGK--TSFKDSKQ--KWIQPQNLSLVHHFTKLIDPKDGLKS-AAMVFALSRTGIEKNR----NKS----------------------SDVKELL---------GE-------EGEDVTSPY--TS---------------IHVPAF-------SMSELENFVRLYQQ-----------RGGFQ--KDLTSSL-LHEIALL-TG--GSGHLASLLCGPR------------------------MAAISRGRLSLSLPFYSRSFCAVASK--------------PNSRS--PQT-------------------------------------GIPIIIPPHVIKK-------------------------------ANIVHPKSRAVHPLLKHQWLTKTVF--EKGLPFSSEENQEQTELAPE--------VAQLINERFG-----GSLAQTLGFQKQPNKT--------KKRFEEEIRYGI--FQDLVRLCSGNLT--------DTFVDVCPKVLTHWVR--KHEF----------------------------------YQLEFYPDVILRSGTEWDAY--------LEDFQNTEEMT-------LPGP----------YDPYSMEV------------YKQPI---VHLKNFPGFH---A---ASSNPFPHNHTMFLAN------AF------GQRLDQ----------THAFGIMSMFGVLASTAMSRGVKPGEHLSEPVCTQCVITDGRQLVLMCYQLNTM-SLQEDHGV-------KNLAWGTDYMDLF--KDNASEKGHTGLFGSLNIDQEI---P--SVNEDSVRRLLFFLCC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKDYNEQFKTRSKPVEQ------------------------------------------------------------ISLTSGSRLTLFDEVFSAKEFLVPPEKLFLTEQETLDGLVNMKM-----LDYRNDFESLIALAD--RQWKFPVDNEVCKVDEAIVG----------FEEHVF-LGYLLDE--F---------------PKKGPVRQ-FMELVICGLEQNPHLSVSQKKDQVAW-FKDYFEKIPKEELTF*VIPLDDFNMSSLIKRPSDNVKFGGVSIRQSSHKFQGANCVFQAHLK?----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSTNYARKMALL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QARIFGKLTRP---------------------VTKQSYKVVTHFSRRPL--GGAIN-SYYPPLKQ-FNSLLLRLRHLGFYRDDHLD------------------FKEEMAVRRKERGK-GPPK----------KVPWKTKIY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAMSSGKIGSTKFPFLRSISRVTLLK------KCLIDN-----------------------LPCSSYASQAGKAASQMMKRE-----------------------------------------------------------------DGPRLGSRGRGGRTRVGTTILKNPS------------------------------------------------RAVTM-------------------------------------------------------------KPESTDWPSV---------------------------------------------------------FSGPQ----------------TYNPAII---------------------PVF---LRMG------------------RRKHNRLDNFPQRT--------------------MANLELMKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNFFHLSPPAIERHCQALKP---LCKPWPKDLDPSLR-------PL-RVITRNYLFAGP-SLHHPGSKKVKLQVFLKDL-ILDDHARTKLIELVG--------------------ER--------YNPVDDSLTIVTDRCPTRQQNNDYALYLMTVLYNEAWKIEPWETEASNEIC-DDES--------DEPIRKRRNAIRLRLV----------------------------------------------------------------------------GDELYRFNKYGKGFKLHVKVKV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Neurospora_crassa MSTHPGSTARGPSRAGGSIAQPQNRSATPYGQNHAGSAIPRPVLETQHAATGSEVGSASVSVSRQKQSKRDEAIRRKMESDLSKKKHLTSRARHTRKAPPGTVLALKPSPALQIKAATTVSEAAQLMAAKREDCVLVTDDDERIAGIFTAKDLAFRVVGGGLKANTVTIAEIMTKNPLCARTDTSATDALDLMVRKGFRHLPVMDENQDISGILDITKCFYDAMEKLERAYASSRRLYDALEGVQSELGTSQPQQIIQYVEALRSKMSGPTLESVLNGIPPTTVSVRTSVKEAAQLMKENHTTAVLVQDQGAITGIFTSKDVVLRVIAPGLDPATCSVVRVMTPHPDFAPMDMTIQAALRKMHDGHYLNLPVMNDAGEIVGMVDVLKLTYATLEQINTMGSGTDNEGPAWNKFWLSLDHETESMVSGDGSLHHTHHGPRSLMSPDIARSERIVDSVAPGDSASHAGIESPSHSQLGGIQEVNPADIPFPFKFKAPSGRVHRLQVTASHGMAEFVAAVAAKLGAEVDAIGGTPEVENGRLSGGFALSYLDDEGDSVSITTDQDLLEAILLARHGLREKVDLFVHDPSEPAISHAPTPAPVIETIPATPPASSVVRERRKKVEEESEEVSEEEEPVHRRPTRTRTMSQPQEAPQVIAGVPNELLLPGAIVTLAVVIVSVVAVVGLEKLLIMDCPIQQFSSHSPVFERLHIDIENLEIKISASGIMAFLLDTPARPFPDPRIPVVGPFQCLKEAALRYTSSARPHWCSDPRLAGGCDAES-RRALATPLSRASFPAQSRFLSQDNFTAPPPPPTNSKKQAAKTAFAEPTL------------------------EEQAEFYAESIEKHTPEFAASPAAEAWSAPSATATETVTTWDPSLVDEEALKLKQQIEAIPGNFKLFKQTKAQTQKLGAGVEVRYIPEQYLRNPPSDASLEDLMAAQAHMGHNTSLWNPANARYIYGVRQGIHIISLETTATHLRRAARVVEEVAYRGGLILFVGTRPGQRPIVVRAAELAKACHLFTKWRPGTITNRE------------QLLGGVPLTVVDELDRPLSGFEDHLHDRRPLAPDLVVCLNPKEN--------MTLLYECSLAKIPTIGIIDTNTNPSWVTYQIPANDDSLRATALISGVLGRAGERGQ----------------KRRLEAAQRGVVTWKTPADVQGYFELASARAADARRRQAQDNSVEEQKEKDTFLSEDALKAMFGGDARI---------------------------------------------------ARVIKIMDVILNKANLPKINRVQEKASLIKSVDWNLLENKFKNLNLSFILNDASYAERNNLSELLNKLYYNVLLVSQKGVWALRSPKGEQPSFHSKSGGSPTKFIQKGAGA-----ASLGGNAKAQPKVSSFAKAKKYAKIYQIIFNSINYKNMGGLR-LEIKG--RLTKRYRADRSL-----FKV------------------------KWKGGLKN-----LDSSYKGL-----------------------------------------------------------------------------------------------------------------------------------------SSVNMRGYAKPNVEY---------------------------SIFTSKRRIGA----------------FAVKG--------WVSGK-MKIRRLFKYHSLKK--KPIRPTWNKYNLYNLATAGREPRISGKTFFQQKWLAKSLTRAYHGEHIKERKWARMFS-RRLPAVVNMDPAYMAKYNGSEQAAGRGSGLSEPPAYEKTADEKPAKQVIANPGRKVPTPYEQM-TFAPLERRLDIAIFRALFASSARQARQMVVHGAVTV--NGKKACTPSQRSNTESHNTMKHPGYLLNPGDLFQVDVERVLYATGAPKDKKLLAAAMKAAKKELAEEAQEAAEEKDAEAEEAEEGEAQEAASKSGKKEKQVDTSKFDEAWNRKYELLQLQR-----------------------------LLQYAKHIADSPSHQLSATRKQALRA--LKRDIKAAIKQAQRRDGSVSPTGNVVDDLTMLLERLAVSPSKAIQQEEAAK---------ELSKKLDKQSRQVLKKVIEYN----------------------------------DEHEDNEIDPSKPYMTPWRPRNYMSAFAFIPRYLEVNQNICAAVYLRHPVARPGESEVPSPFSPTINQLAFNWYLRRG------------MSAARFAARSFLSRRLAATVPAAAPAASTPAASTCPAAQQQQSQFHSSAHLEARRRSRFKNVRAVEMGLTSDAKIESFTKKKFAEYTEDEKAALAHNYPAEHMEAIEAAEAAIDPKDLTIQGRLRVDPYRMPYIDDFSEIQPIIDKRARRSAP-PSHKARFMDVDEFTQDLINWADEIRRGEPTHRMKKLRDFVPEEFFEKPEGQWPKDVRDEAFTKFWAYLKEQKDADAKAAANATGPTDGDILSYILERSSMTDNNLQANSSLAPALPDKVPGVEGKYRNAIDPADDGLDDKGQYQELKKRTGMSVRQILQ--LKTKKLVHRRVVNQTRL-GKIASDSVMVIAGNGDGWLGLGMAKSV-EA-SIAVEKATLLAIQNMQPIPRYENRTIYGEVTTKVSGTIVRLNSRPPG----------------------------------------------------------------------FGLRVSHRIFEMCRAAGIRDLSAK---FLRSR-NPMNTVKATYQA-L--------------------------------LSQPNPEDLAIG-----------------RGKKLVDVRKVYYG-GSVY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLYETIGIVR-PGNIAE----VKELVLTAGKLILNQGGVIRDI-K---NWGT-FLLPR----PISTNQQRH-NRGHYFVMRYDASIATHEEVR-----RTMKADPRVIRTANV-KLGDGKLET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSR------------FGAIPWRSLEEA---------------------------------------------------------------------MPARLGLSAAFRSLSIRTNQLPQQQSIAAAVQARTLITDSTTSSRLPPRVQIQQQQQQ------------------------------------------------------RTQPYSTETTPPPNSNNGDLAGIEGQPPVEVTPENAAALSQLSEIAYGVKAADVAIEGHKYGLPTLPLPSELH-------------HKYRYSEVVNHATKLLMKDGKLSKAQ--RDMAMILNYLRSS----------------------------------------------------------------------------PPPK-LNPSRPLIPGHPPASHLPL------------NPVEYL------TVAIDSVAPLIKMRGYKGLAGGGRSLEVPQPIPARQRRSTAFKWILDVVNKKPSKGSGRTMFAHRVAEEIVAVVEGRS-----------------------------SVWDKRM------------------------------LIHK---LGTANRANLNSPALQLKGKRFMGIQQITNMCSHLQNASRARLGLTSLPNTKYNLALALALHRAGFIS--SITRGGPHPPTPEALMTYEPEPVTSANVATRRLWVGLKYWNEEPVLKELKPISKPSRLVTASLEQ---LNRVARGFPAGYMK--------GLQLGECLFVNTDREEEEGGGSQGWTV---GIGHEFGERKALLGRKREE-----------------------------MASLRHSITSALR------------------------------------------SSRQGCSKSAQWQS-----------------------LDQQFGALR----ISS-----RSLSTH---------------------------------------------------------AHDHNPNVDGQFIAAPALSIDNF-----------------------------------------------KLHPYARAV-----------------------------------------------------------------------------------------------PVSPSY------------------------------------------------------------------------------------FTRTPRFYDNYLSLEKL-------------------------------------------------------------MEEYEDLPVIPATAVE-------------------------------------RVAWKTLEDIRK-ELGEQVKASEFARCLALVKRLNSIHPDLKPQEI-KDVLDSFRRN----VQPFTNVAKPIPIDQ-----FGRACGV---GKRKASS---ARAF-VVEGTG---EVLVNGKTLAEYFGRVHDRESAVWALRATNRIDKYNVWVK-----------------VEGGGTT---GQAEAITLAIAKALLAHEPA-LKPAL------------RRA-GCVTRDPRKVERKKHGHVKARKMPTWVKR---------------------------------------------------------MIIRPVVRSLQGRAPLATLRSAQSVFQPLPQLRRNASVTTPIAR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITTTTEAPKDQKKAKAAAAAAAEPEEQEVIMSRMPRSLE--------------------------------------------ALYLQPLRREAEYGVPSCDLQLRSYSIRNLEFFCDFALRAAYYLGLPAFGPVPLPR-MIERWTVPKSHFIFKKSQENFERVTLRRLIQIKDGHPETVQLWLAFLQKHAYYGIGMKANVWEFS------------------------------------------------------------------KLGVSKAMDESKSEVEKLLET------------------------RWEHLSHVSDMKGVGNFEDFLAKERLRISGGRMAGQIDPIRAELVGWTPRVPRNLLASLPPLGRKTAPKLPQNISFSPPLSAHPCYQCQEKCLPHRRPVSWSPLILQRCRLRCLPRGHPLKISRTFELPVGERDGSHPLTAFARAPRTTEPRSLHYLYDSLPPTPALCAQLLFHQLIQGHFSFVVHPTVATAPRSIWPAKMSRFSTGRLLAQNLFQAFNKPVFPSATPVWTRAFSQTAARRDAD--------------------------------------------------------------SESSAKLMESLTRGIVGMAADPTDLTGDKLATNIGLRDTEDEPY-----------------HFHIY--SHKHNTHITVTKPNR-DALISLSCGNLGFKKSNRKHYDSAYQLGAYVVDK-MHQMNLHNKIKKMEV--VLRGFGPGREAVIKVLLGNEGRMLRSSIVRVSDATRLKFG-GTRSKKPRRLG----------------------------------------------------------------------------------------------------------------------------------------------------------------MRGVCVKVGITRPKKPNSGERKTARVRLS---TGKVITAYIPGEGHNISQHSVVLVRGGRAQDCPGVRYHLVRGALDLAGVATRMSSRSKYGTKKPKKASVG-MVFILGVNFNEHKLVQKALES-FYGLGQQASARILAKYSIHPRAKMGTLPPKIVTAL------------TAELSTMTIENDARRLVLDNIKRLRD--------------------------------------MGTYRGRRHAMGLPVRGQQTRNQIANARKLNKIERHG--------------------------------------------------------------------------MSMFRAKKLDLGC-------------------------------------------------------FTNV---RVLRDHSKRKAFLEAEPERQALRYVIRNTTLPARTR-----------AVAQLQLTQ-MHAYTRPTQIRNRCILGGKS--RGILRDFKMTRYNFRMNALMGNIPGVK-K-----ASW-------------------------------------------------------------------------MPPRLPGPQGLRSLTLCLRPAVASPAQALQPLIQTANISQKEKKRKMKQDPYGWAQAQQRKAVNVKRQAELQAQRDAAWGDPVKG-------------------------ITTPFVESFDSAGQASVSPPKVGPDGQLVEEPKPLPTSPHLRNYLLNKDEFDSAIQYAEHILKPIKAEDRLTADPEKEDEEAREHAARHAKAVAALERIAKL-EHGGAKDRKHANIRRCIETFGRHITDQSLERPTPPLARGVEPKPQPVRAGPDTGSSEVQIAILTSKIRA---LSKALEGH--GGNRDKNNKRSLRRLCHKRQRLLRYMERKERGSGRWHHMLETLGLTP-------------ATWKGQITL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVLKLRLARFGRT--NAPFYNIVVA----HAR---TARN-SKPLEVIGTYDPVPKKDTYDTTGKLH---KDIKLDVTRAK--------YWIG-VGAQPTDTVWRLLSLVGIL---------------------------------------------DPKYKKPQPAQ-------------------------------------------------------EQKTKA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASTIAAATKVSRKMFRELHGVVVTS-GLIDKT----VKVRVGGQKFNKFLQ-KHFDDPKQYLVHDPNNSLRAGDVVAI--MPGFIT-SKS-KRHVVKHIIAPAGTPI--------------------------------------------EERPPIPSLDELWDAKDAA------KAAKKERKVLREKMQAAEEAIELAERMARHAVREIAMREKIISLQKVD--------------------------------------MSSSRQFLSSALRQCRAA----------------------GQRTAQFSTTSPAAAIR-----DIPTTSFQNAPRTNT--NTSSPSSNNNNNAGS----------SQYKSD---MFNLLNSGA--GSRGGRDSYNN--------ARDVDGG--------QRYGSNSQKVQELLQSEVTSNNYMRMMRRRWNNGDVYAPR-DLSPYEMKGRNGGW------------VEAADV----VDELGFSPL---D---------NY---RNFSLISDYITPF---GRIRHSKETGLKPVNQR----KIAKMVRRAIGLGIHPSVHKHPEILKNSNGRHLLPLVVPKGQKANKTKNFDGEDEN------------------------MQPTRVLFKRSVWKGPHIVPLPIQRPEPGKKIAPIRTQARSATILPNFVGLKFQVHNG--KDYIDLTVTEEMVGHKLGEFSA-----------------------MELRSALQSVCRTTAAAASASARSSLAGRHAFSTSARFQLQPPPNPYVSGKSRIETLRAALSNRKPAAGAAAGGSPGATSASSALPPRPPTANDSPWSIVDAINKDSNSSTSSSSSSSSSGGALYSSSKPSPMQTWNETDFETRHMAPQQELNIRLRPSTGRTFYVSGHQDFAG------ALKLLHRTVAANKVKKDVRLQRFHERPALKRKRNLRE--------------------------RWRARFKEGFKAAVNRTFEL-KNQG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------W----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGKGRIFQAAKVYQRASEAAATNIVSGLPPRNPPLWLKAIESIPPAEINTRPYPIQHSPPNPRA------------------------------RKPRNLFRPTKIVYPEDELRRDFYRDHPWELARPRMIIELDGKDARFLDWSKGLRQRGIPLSGESVVQRQLWLMEN--QGMTKQEAYDKARHEFYKLRQLEQMERRIAVEEARMVGGYFGKDLLTVGMELENKTYESWKKWATTEIARQESARASMYTNVVDNSALEESEEDELLAQN--------------------------------------------------------------------------------------------------------------------------------------------------------MS--SGKRKFWRENLP-KLKYWNPAVPM--VINRTTDQKGPAVMTI--YFR----DDKDAKPSSTPFPTSSADGSSPAPKPAQG------------------ERIVTIDMKNRNSS--VI----------LKEFLDKTGAVAVQPTAKDEEEFREFEDLHRRSEIDRERIRKMNDAKK-------------------------------------------------RE-----------KAM----LAKAMSDAQS------IKAASA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSASNCLR-------CLVRPSAVALVPRQMLQVGGGSLTFTATAATKGASSANTGGRQNANRPQKLRFKKTKKKNVVSSGKPPLPGE-------------------------------RKAYRKKIVLSNNN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A----------LPVPGLETLRPNDLAKQDNVGSVKAL---------PEDVVDALRAMEAFKP--------------------------------------------TQCWGIFRQPSVLIRQETVDLTKKM---KAAGAD----------------GKTIRMVIEGNRVTGKSLLLLQAMTHAF-MNDWVVLHIPEAQELTTAVTE--YAP-----------------I--E-NSPLWTQPTYTLKLLQSFKRANEKV-LS--RMNTVYSHADLPQ--IIPVNSP---LLQLINSAKEADG---------AW------TVFQALWRELNAENVP--G-------------RPPILFSLDGLAHIMKV--SDYRNPAF--ELIHSHDLALVKLFTDCLSGATVMPN-GGAVLGATTRGNSPRS----ASM----------------------ELAIAQREAEKA----GE-------KEVPQRDPY--SKKYDDRVEAVMKSVEILRLKGV-------SKTEARGLLEYWAA-----------SGMLK--KRVDESM-VSEKWTLSGN--GVVGEMERASLLTMKA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSVPRARLLQLVKA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RCELFSTTFNP------------------------EGIRTGNKILRQRL-KGPALA-TYYPRKNVGIRELQKEFGTLGLEVDDEVDDDRLEHLAAFVSLIPASVYLQTSQSNHTL-QS-ESPR----------QGSAQEEENGTLGGRWVSSAPLTHGSNL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASSANALRLGLRTCSRPTQTS---------------NLRIAA-----------------------LQRRALSATAT---------------------------------------------------------------------------RCEGVPVPKREDDAKLEFTRPYNPG-----------------------------------------EFLSEKLRSDDL-----------------------------------------------------------------QDWERE---------------------------------------------------------RYERA----------------LTSWEQT---------------------PDD---LKRG---------WSTMIRDIEQAAAPLRRVVMPRRSTFW-------------YEEEKDTDLITNE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGEDDFHE---NDIMSLGHGKLEEHRE-FRE---YARIAVWEMPLLSKYAKPFVPPT-SEEVLRFRYTTYMGEFHPADRKVVVEFCPKDLRDLSEVQQRKLMKLAG--------------------PR--------YNPEKDIIKMSCEKFEHQAQNKRYLGDLIEKMIAAAKDPKDTFEDIPLDTRHHTFTKKISFPKEWLLTEERKKELEAARQQALLKDAEK-----------VVQGALVDGADVVKQYLESGA-----------------------------------AEALHAVPVMAGRGGKALPGGKGGKMQRSKR--------------------------MFAATRVLRQ-----------------------------AAAHAERV--PSIK-------------------------FIGRRTIPT---SVDHTPKPHPASPTHSLPANWGSSPSFSAYRQHAQQHGP--LRKTIRPDVDGIGGSPGAALGSVNPPQGLYFDRNDLPARFRRQPLTEAEIEAIES---------------------------------------------------------------------------------------------------------------------------------------------------------------------------GC--------------------------------G-FA--------------------------- Saccharomyces_cerevisiae ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQRHVFARNFRRLSLLRNPSLTKRFQSSASGAANTPNNNDEVMLLQQKLLYDEIRSELKSLSQVPEDEILPELKKSLEQDKLSDKEQQLEAELSDFFRNYALLNKL-FDSKTLDGQSSTTTAAATP-TKPYPNLIPSANDKPYSSQELFLRQLNHSMRTAKLGATISKVY------------------------------YPHKDIFYPPLPEN-----------------------------------------------------------------------------------ITVESLMSAGVHLGQSTSLWRSSTQSYIYGEYKGIHIIDLNQTLSYLKRAAKVVEGVSESGGIILFLGTRQGQKRGLEEAAKKTHGYYVSTRWIPGTLTNST------------EISGIWEKQEIDSNDNPTERALSPNETSKQVKPDLLVVLNPTEN--------RNALLEAIKSRVPTIAIIDTDSEPSLVTYPIPGNDDSLRSVNFLLGVLARAGQRGL----------------QNRL-----------------------------------------------------------ARNNEK-------------------------------------------------------------------------------MKLKLLNMILSMMNKTNNNNNII---INNTLDSLMNKKLLLKNMLLDMNNKKMNNMKRMLNNNNMNPAGANPVVHRIGPAGNINNKLQHLNNMNNWNTQIYNYNKNMEIMNTMNDKLINKLLYKMMTLKLNNMNIN--KIIMSKTINQHSLNKLNIKFYYYNNDINNNNNNNNNNYYMNMMNKLMNIMNNNMNNNLCNILSYYYKKKVTIEPIKLSYIYLNSDIFSKYISLNDMDKYNNGILTNYQRMLNNIMPKLNDHNISMNYINNINNINNNKYNNMINLLNNNNNINNNNNYNNNNNNYIGNINNIYNNMTIDNIPMDILMYKYLVGWSIKFKGRLSNNNGRTSTTNLLNGTFNNKKY--------------------LWSNINNNYKLNYIPSNHNLYNNSNINKNGKY-NIKVKLNFI-----MPRKANLLKSLAR--GRVRTSFNKYNLFNLYKKGGVD-LKSKSLYQQKWTAKQETRAYHGEHLTEKRWQTVFK-PKLDSVAQLD------------ASLRGGEIKE-------------------------TPF-LLQTFAVLEKRLDFALFRAMFASSVRQARQFILHGNVRV--NGVK---------------IKHPSYTLKPGDMFSVKPDKVLEALGAKKPSFQEALKIDKTQIVL---WNKYVKEAKTEPKEVWEKKLENFEKMSDSNPKKLQFQEFLRQYNKNLESQQYNALKGCTQEGILRKLLNVEKEIGKSNNEPLSIDELKQGLPEIQDSQLLESLNNAYQEFFKSGEIRREIISKCQPDELISLATEMMNPNETTKKELSDGAKSALRSGKRIIAESVKLWTKNITDHFKTRMSDISDGSLTFDPKWAKNLKYHDPIKLSELEGDEPKARKLINLPWQKNYVYGRQDPKKPFFTPWKPRPFLSPFAILPHHLEISFKTCHAVYLRDPVARPGQSEVISPFDVPVHERAYMYYLRNGK---------------------------------------------------------------------------------MFKRQLSTSVRYLQHYDESLLSRYYPESLLKSI--------------------------------KLAQQTIPEDTKFRVSRN-VEFAPPYLDDFTKI------------------------------------------HPFW-----------DYKPGMPHLHAQEENNN------FSIFRWDQVQQPLPGEGNILPPGVSLPNDGGRKSKSAD-----VAAGLHKQTGVDPDYITRK-----LTMKPLVMKRVSNQTGK-GKIASFYALVVVGDKNGMVGLGEGKSREEM-SKAIFKAHWDAVRNLKEIPRYENRTIYGDIDFRYHGVKLHLRSAKPG----------------------------------------------------------------------FGLRVNHVIFEICECAGIKDLSGK---VYKSR-NDMNIAKGTIEAFT--------------------------------KAQKTLDEVALG-----------------RGKKLVDVRKVYYSS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLYELIGLVR-ITNSNAPKLEAKELSSTIGKLIIQNRGVVRDI-V---PMGI-RYLPK----IMKKDQEKH-FRAYHFLMLFDSSAAVQSEIL-----RTLKKDPRVIRSSIV-KVDLDKQLD-------------RAS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLHRSL------------GKKSILELVNEDYQSI-------------------------------------------------------------MLHCARRYMLVRPRLLWQSGTCVARFQSSVRTPASEPSAEKGVDE---WL----EAINELRE------------------------------------------------------EFSAK--EYLP---E-TSLAPPGQSKVDLLQGSQAGSKIKPTAE-----------------QLAQWEALKSVP-------------IPPRKNATLDHITNMIMRHGKKEKAQ--TILSRALYLV-YC----------------------------------------------------------------------------QTRQ--------------------------------DPIQAL------EKSLDELAPLMMTKTFN--TGVAKASVIPVPLNKRQRNRIAWNWIVQSANQR-----VSSDFAVRLGEELTAIAKGTS-----------------------------SAFEKRD------------------------------QIHK---TAIAHRAYIQLK---------MSLVKLANTCAHLQNCSKVRVALTSIPYTKLQLQFAYNLYQQGFLS--SLQKGSTMGPDKDFV------EVTPDNISTRRLWVGLKYRDNKPVLSSCKLISKPNSRIHLPMED---MKKLCSGVTIRNIK--------PLQPGELILVRAHNNIMDINE---------AISKKLDGE--VLCRVK---------------------------------------------------------------------------------------------------------------------------MFSRLSLFR----RAA-------------------LAPAPMRM--------------------------------------------------------------SFRTIYQKT------E---------------------------------DELPRRIV------------------------------------------------------------------------------------------------PKLATF------------------------------------------------------------------------------------YSANPNHEDRINRLERL-------------------------------------------------------------LRKYIKLPSQNNNEAQ-----------------------------------QTKAPWISFDEYALIGGGTKLKPTQYTQLLYMLNKLHNIDPQLTNDEI-TSELSQYYKK----SSMLSNNIKIKTLDE-----FGRSIAV---GKRKSST---AKVF-VVRGTG---EILVNGRQLNDYFLKMKDRESIMYPLQVIESVGKYNIFAT-----------------TSGGGPT---GQAESIMHAIAKALVVFNPL-LKSRL------------HKA-GVLTRDYRHVERKKPGKKKARKMPTWVKR-----------------------------------------------------------------------------------MLRNTIALRSFIRTQSTR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PYPVNVEAVYYAPLKLPIKYG--------------------------------------------DLV--------------ADIQLRSYDNENLDFYSDFILRTGYYLGIPLTGPKPLPT-RRERWTVIKSPFVHAKSKENFERHTHKRLIRAWDTNPEVLQMLIAYITKHSMAGVGMKCNFFQRS------------------------------------------------------------------------------EISLDLGSDANGLEKSLSNIDELYSLRNDDKAQTSAVGQKVLELLDSPDFKKHLEKK-----------------------------------------------------------------MLLQPVWKGCRWTQFVRPIR-----------------------------------------------------RWNSTGTNRGV------PFSFKDISN-----------------------------------------QEDITNISYPSSSDS--------------------------------------------------------------VLTKSNGSSEVYKPKEEVVKYILHGKFTKNNTHLTFSSVVEDK------------------NFHKNKGLTYNDTMLYYLNLPQ-KVKISLSTGCLGFRKAARGEYEAAFQTSGRMFEL-IKEKNMLNK--DIEV--VMDDFGKGRAAFISALVGKEGASVVKKVVKISDATKLKFG-GVRSPKMRRL------------------------------------------------MLSRFMSNTWCTPLRQAQRLFSSTTTMQ------------ATLNQIKRGSGPPRRKKI------------------------------------STAPQLDQC--------PQRKGVVLRVMVLKPKKPNSAQRKACRVRLT---NGNVVSAYIPGEGHDAQEHSIVYVRGGRCQDLPGVKYHVIRGAGDLSGVVNRISSRSKYGAKKPSKS---MVVHILGKGFKGKEVIKIALASKFYGIGKTTAEKICSKLGFYPWMRMHQLSEPQIMSI------------ASELSTMTIEGDARAIVKDNIALKRK--------------------------------------IGSYSGMRHTLHLPVRGQHTRNNAKTARKLNKIDRRGIHTFSQAKVQHNPSLWSCIFGK-------------------------------------------------------------MGNFRFP-------------------------IKTKLPPG-------------------FINA---RILRDNFKRQQFKENEILVKSLKFIARNMNLPTKLR-----------LEAQLKLNA-LPNYMRSTQIKNRCVDSGHA--RFVLSDFRLCRYQFRENALKGNLPGVK-K-----GIW---------------------------------------------------------------------------MSIVGRNAILNLRISLCPLFMGKRSFVSSPVSNS--------------------AKAVKFLKAQRRKQKNEAKQATLKASTDK-----------------------------------------VDPVLGRADTPFITRIMAELKEPLVLSKGYNIEEVDKFLAAIESAKRERAELSG----LNTEVVGIED-IEKLEDRREAILRILSM-RNSENKNAIKMAVELARKEFERF--------------------------PGDTGSSEVQAACMTVRIQN---MANHIKEH----RKDFANTRNLRILVQQRQAILRYLKRDNPEK--YYWTIQKLGLNDAAITDEFNMDR--RYMQDYEFFGDKILIRDSKKVANQKRKEIRKQKRATF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------MTCGLVRIRLARFGRK--NSPVYNIVVA----NSR---KARD-AKPIEVLGTYVPVPSPVTKRELKRGVVPIKDVKLDFDRTK--------YWIG-VGAQPSETVTKLLRKAGILNDAW----------------------------------ATSKNSNVNRKVVFERME------------------------------------------------------TLE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MARQNFLGLVVSQ-GKMQKT----VKVRVETKVFNKKIN-KELFHRRDYLVHDEGEISREGDLVRIEATR-PLS--KR-KFFAIAEIIRNKGQQFALYESEAQLSVAKEEAQKAKEFLDKRSVRENKLNEKTTLLRDIRTIQDALSSGSTPKELLEIKQRYGIQDFSQETVRQLLQLDISGLEVNLEKQRSLIDRIQTRLSELLSNDLKCDQFLKDHGVEDPLTLKKNIKKNLLRKHVMMDMQQPSQMFYYAFKLHCRVT------------------------------CWGKKYLGLLYILKYESIINSVTVLTKKARFYTKLR--------------------------------------------------------------------------------------MFKMNATTGIKI----------------------------------QNGMQPI----------IKGAV-----SSTFKRALYNFGIKEKK-SVNIEMGRTQQTKKIDQSLSKKLPKGTIYDPF----DFSMGRIHLDRKYQANKNSNRNDIMKSGANPLEFYAR-------PRILSRYVTSTGRIQHRDITGLSAKNQRRLSKAIRRCQAIGLM---MQPAARLLSRSVWKGPNIVPLPIR--EAMTKGTPIRTNARAATILPQFVGLKFQIHNG--KEYVPIEISEDMVGHKLGEFAPTRKRFSY-TQTKNK-MLKSTLRLSRISLRRGFTTIDCLRQQN----------------------------------SDIDKIILNPIKLAQG---SNSDRGQTSKSKTDNADILSMEIPVDMMQSAGR------------------------------------INKRELLSEAEIARSSVENAQMRFNSGKSIIVNKNNPAESFK--------------------------RLNRIMFENNIPGDKRSQRFYMKPGKVAELKRSQRHRKEFMMGFKRLIE---IVKDAKR-KG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKIQTNA---VNVLQRTSAYLKSGL---L--KETPAWYNVVASIPP--STKFTREPRFKNPSNGHIIGKLVDVTEQPHANNKGLYKTRPNSSDKRVGVKRLYRPPKLTYVEDRLRSLFYKQHPWELSRPKILVENEIGDENYDWSHMLQIGR--PLDGESVIQRTMYLIKTK-QYGDMVEAYDHARYEFYALRMQEETEQQVALEEAEMFGSLFGVSAIEHGIQKEQEVLDVWEKKVVEETELMAARTSNPAGSWKDDTTLNTAQEEESTTSENLHF----------------------------------------------------------------------------------------------------------------------------------------------------MS-------KVAQQLK-FLNKISATTRLPQIL-----VDPKKYSGLRLTFQ---TKNHNGHMGARVFWH---------------------------------NYLPTLQFYNPRMKFDVIRIKNEDKQKSVPCKL----------------EI--LSHEGSVVE-------TIDMRNK-------------------------------------------------MHEDIMKDLLDKIEHVP---LPENEIIRV---------GPQESII-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MYKNIYICIL-------YIYINFYTSRENINKRTSTSHVVIRIRIMLRMS--------------TSRFIGQ-RLFTTARSLQAAKPAPKGK-----------------------------TQGFSKKSSSVSSY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSAKRVTP----------GSLYKNWTNTTHTAQLQQTAVPLALPIFNFDDISKTLNKV-VSYSNKQY----------------------------KSLHHLGSFKKSQFNELFQKPVCLVRE---DATNSF---LKKLVS----------------HPVKKFIITGEPGVGKTVLLSQAHAYAV-DSKQIIINISYPELFLNGRND--FSY-DDDLKLF---------IQPMYLKKLI---------RKILKANDPAL-LK--SIELSKDYKFSNANPKNASVKPFVTLNKTKNTVLDLLSV--------MTHPHNRGKLMKAIIDELSVQS------------------KVPIMFTVDNFSKVLTTAYSAYRNTEN--KQIYSLDLQMGKLMMDIISGETKFAN-GESSTILAISGVDR------TNK----------------------TLPVAL----------GKIPVDPYVTRYHYEPKF--VE------LLQKGNVTEFEVPKL-------NKQEVNELIDYYKQSNVLLDKDITGKKWE--------NL-IDEKYFL-SGNGNPRELLKSLVLSHR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNVPKARLLKVAEL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAKIFDQNFNP------------------------SGIRTGSKILNERL-KGPSVA-SYYGNPDILKFRHLKTLYPDIEFVDLEEQ------------------YRLSMVEAKKRRGK-GAPKKMKKDAAATAKGKGKKKK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKVPLGLWKVSRGNLW-------------------------------------------------STQKRVLTMS-------------------------------------------------------------------------RCLNSDAGNEAKTVREGPAFSADLY-------------------------------------------------------------------------------------------------------------------MHPEKWKGL----------------------------------------------------------PPQR--------------ILELYWERM---------------------------ARLGSEYKPNKDELNALLTTSEYSNVPVNDIKKLYH--------------------RGEQGAIDI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGGNVNRDNSLRPFMFDELPSQAQELVAQHREQRFYNRLAAYELPLLAQYRQEYKRPSPESHPVTYRYTSYVGEEHPNSRKVVLSVKTKEL-GLEEKSLHKFRILAR--------------------SR--------YDHTTDIFKMSSDKFEHASQNARYLHDILQRLLAESKDLTEDDFSDVPLDTRHTIA--------KSLRKKKRDYEFPEHW----------------------------------------------------------------------------KRPEDAPKKKFDIVDQLLSTL-------------------------------------MIATPIRLA-----------------------------KSAYE-----PMIK-------------------------FVGTRHPLV---KHATEVVVHPCATNGMLPG----SKECIPVSKFMENYKPFRVVPIKHSANAGLSSSKTSVFVNRPLQKDELASIFELPARFRYKPINEHELESINS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------G---------------------------------G-AW--------------------------- Salpingoeca_rosetta ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLASGGAKATGMASGVVAAVLRHVSRRIPATATGTP-AAAAPRW------------------------------------------------------------------LPHV-----RTATT-----------------------------------------------------------------------------------FSMEDLVQARVHLGHTHGVNNPKMDDFIYEKRHGLTVLDLDKTVPLLQRALDITREIASRGGVILFVSNRPQFETMVRRTATSCGEYFVSKKWVGGCLTNTY------------RVLGG------------------------MQLPDLVLF-FSLPV---N----QAALKEVRDCMIPCVGLVDTDCDPSSVDYPVPANDDSETSVNLMLDLFAGAVNEGKAELARHPETSYRFDVEEYRQQLAEAAAGRQQRPRTAGTRRLDLTRMTTLDPALAEQAARVHHHQQQQQQQQQQQRQQQQQQRGGGDRRGRRGAEEKPANVKTRVELDSAEPQEVDEATARVAGAHRYRTRVVVPKK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKSYPVWKL--------------------------------------GEIKKLGCGVPA-THFSRCNLTEGSPE-------------------------------------------------------------------------------------AEEIRKMLADAK--------------------------KDLKPPTPPVPV-TVNLPD-----GTTRRQYAFDTPAVPPLPAREKITPGVIHT--------FAVYRLN-LG-TVLGMQPRNRTC-------------VAHDVQAKYLKTKVYMRPAKPG----------------------------------------------------------------------HGVKAHPLIQMMCELAGIEDLTAD---VVGST-NPLNVAHAAMEA-F--------------------------------KAQRDPVDIAKM-----------------RGKTLIQI-DDPGR-LPRVLYTP-------PPSAAPTVPLPGDVRRSVKSWLRAFPRPGDMAALGSAKLAFDKLVSNAWTERGEDGRHFRNKLIHVRGGLAIVKGLDDDISAWFQSQPPRASPMDLQVYTRKSFLDDSFW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGGVHASLDYHATISTAGTTTSASTQQQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPSYELCMIMR-ALRSEA----LAKELVPILQRVQSLGGVVQDV-K---SVGS-QPLPH----KMKAHFEHH-DKGTYSFLRFESSPTALPQLD-----TALKRNSSIIRHNFV-KLPALDAKP-------------MTC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFKPKR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MCGKKTTAE--KILKNTLHLIKRG----------------------------------------------------------------------------ELDRLRKERADSIRNANPDADVQSILFEEAEHV---DPMLIF------REAVSNCMPTVALTPMR--KGATVYQV-PTPLDPRRRQALAIKWLIAAARKR-----QGKPMAEKLYTEIMDAYNNQG-----------------------------TVIRRKI------------------------------ETHK---MAEANRAYASMRWSR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVWQVARQRGTVVAMASVSRAASRGSAV-V--------------QA-----------VRSVCSARPTQFPRRKVVEPNQSNIVHDEIKEV----LKGTNLEHI----QDF-----RHLYRLLY------PGPVPPNY--------------------------------------RDLITVDAVRKELMYLFPSPLIRPDFDPIAKRV------P---------------------------------LEQLSNNCIE------------------------------------------------------------LDP----------------------------MFRPTSAAH------------------------------------------------------------------------------------FTGNPKFFNML----------------------------------------------------------------------------------------------------------------------------------------------AYDE---LTAAMTEVYYHPLFEELGQQSLKRFMTE----TVDTTVAVQQQQLDS-----KGRAHAV---GKRKTSV---ARVW-VWPEPGPMPKMKVNGRPIAEYFKDTDKLLAALAPLRRLDVADQFSIMCN-----------------VHGGGVT---GQAEAISLGISKALVTLRPE-LKPEL----------------------DREVAR-----------------------------------------------------------------------MRQVARRWCWSVGAAARAAPTVTAQQAKQGAKRAVSITTTTTTTTTTGVAAASTVGQMRVFDARHVRAHQQQLGAQM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RCMHVAAAALARGAAAPSAEPATSTANATTAKPKITTYD-------------------------------------IRTHSESGLF------------HSVTIKGESWNYANLDSFFGFIERAADELNIQRGGTVKLPT-HRKEYTVLSSPHVYKQHRSQYVLKTHKRCIKIKNVTEETAASFVEYIMTNAPPGVASRVIMRAAA------------------------------------------------------------------------------SMPRAATTT------------------------NTRTRAARAQ--------------------------------------------------------MVMNVLAKRVVGAVVRCGCLAVEQQQQPSATTVKMAAAGVNRVSAA--------------------------------------------------AWTALRGVVGV------QMQQRACLS-------------------------------------RATTQCNKDNTNKPNNTSSS-------------------------------------------------------------SSSFSTDFLDAMLPDAKGPNLA------DAASHAPVRRVMRKGQAVFDSKLERA-------LARIK--VSHNNTIVTITTLDG-DPIVTKSAGMCGFKGARKSTTYAARVVAQQAGEA-AVNKGVM----TVSV--LVKGLGPGRVNALKGLVESK-----LMIDQVADVTPVPHN-GCRPKKARRL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMQRVQRVVGAVVPRSHALHLGTGARAAGSCVAPPS------------------------YRRTLTAAAPAALARACKWHVPSRV----------------------------------------ARMHTSNSCAVPGKTDSESDPVLDRVVNVDVSSLDAEASNTDLDWLSHPDFE------DPQQFSRHYKD-ALVECGADAIVAQTFHA-SFASQAELTKLRIQQAINKVEGR--------------------------DGNVGSTAAQVAALTARIQS---LIPHFQKH----RKDNHGRRGLLAMVQKRRKLLQYLKRKDFPR--YLEVLQTLNIRPVAGLR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVVAMRLQRFGSR--HSPFYRIVVA----NRR---APRD-GKFIERVGTYNPFPR-------NDMT---KVCSMNFDRIK--------YWLS-VGAQPSDRVSYLLGLAGILPPHP------------------------------------------NRHLLKGTPP-----------------------------------------------------ASSEETQSEE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRLKLVGRVLSTAGVMQKT----AKVEVIRFVKHPRVE-KMVRQRKVYMVHDESNSRMPGDVVRIEECR-PLS--KR-KRFTITDILREEQRLF-----------------------------------------------NPITN----RTETKYS-------------------PPA---------------------------------------------------------------------MLPSCVQLVRRAMVGR-------------------------GAVAGTAASATAALARPAPSVLAALSRTSNTFQRPL------------------------------------------------------------------------------------------------------------------------------------HTGAPVMEATPNRGARGHDLPETA---REVTQGCPA---CPY---KEEIDY---KNVRFLSQFVSPQ--TGQILRRSSTGLCSKAQR----KIAKAIKRSRHFGLMPHVYRAH--AED-------PVFTSGGKHPVPSSR-------------------------------------------------------------------------------------------------------------------------------------------MRHPRFVANTVRLAVAKR---------------------PED--------ALTALSKITRGLKNNG-----------------------------VISSLIG--------------------------------------------------------RKRYTP-------------PFE--------------------------RRRQEENA--------------------------ACVRIYQREFKKKVNLYFEMHPEKRGSQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGK-----------MSTTATAAVAMAMATARRVHVAKGFVARAVACVGATPARAQLHTCSCMHTKYPPRDP------QYDFKMYTLRPAAKAQASDFIHELGLTNNGVIGSRLTIEAVDQYSRMGSNNAQVPLPASTPRSKNTQHSFLLLDEDKVPHFM-KNATE-----YVFPDLEGLDKEYDMPESEVISRDPACA-------NRRFSFVFVDTSEGQTHNTRHIRIREQD-GTLRTATREEHERYNQEFFAEPSKRAQRPAVCR-EESLPGMF--AMNRHKYILDLTVKHLHPYQRDYREVHEAVYKD-VVV-----------------TSKFNALQDSPHWPAFVRWLVRTDQAHV-LISTLMK-ASRFKDA---AKLVHFIK-------------------------------------------------TGSIAIPDSIEENKKIAQDYLQEF---------KPLKGNKNKQQQQRKA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA-------AVRRLPSAVLR----VQEH--VL-----LARGGLAGVKVQVG----HRGPGHAGPRAFVR---------------------------------EHFPSLKFHNEGIR----ATRDVLPEP------NATSKLLIETDTGKTEEL-------AIQGK--------------------------------------------------------------TS-----------DEILDMLMSKGLIEKGAPVD---IKATSA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMLARVQRRLLHAARCVGAAGSTNTTTTSDLLSI----------------------------FSATEDATTLTSSPPQQRSGSRSK------------------------QSKCRLAPTNPVEH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G--------------------------MADANSFFIVDRR------DEPVVSDVF----LKR------------------------------------------RRRDEVRQQGFCSFLLRQSTMKVASII---DAQKDK----------------AALPQVFLIGKDGHGKSTALAYLSYRYW-KEGWVVLPVSSGARWVLEPHY--IDM-STYKPGR---------VDSTRDAITW---------LNSFFKLNSDR-IA--DLKTTKKYTWLEGSHTTAVGTP---LKELLSLIEEDDRS--------SA------DIVGVIVKELLAAKD-----------------RPNVLLAVDDMNGLFEPE-TSVLDENF--KPVNPEDMSLVRTFRKVFRNHSSLDRVGIVAATSTYSGVLADLNDETRTMLNMSHRLSS-------------STPSAAAASSDGDGD-GD-------EEAVVVDDARTVP-------------SSLATSAYKIAYGIASDVEVTSFLDYHNS-----------IGWCNMPSNAKTA---KLLQSL-SA--GNLALLSNHLRAC-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAERLRRLGML-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRSIFGQVVLP---------------------PNVRS--PTRHLKKAT--KAEAMM-RYYPETVMHQNKLLTRMIAAGIYLDEKMI------------------YEGEKKVMNEKRGR-VPTR----------KGEGKRAQKKKKK---------------------MSNILKVVSRG----ALLRDHP---------------------------------QQLHSICNSLYQYGVGKKVCRTIWS------------KW--EEPCYYTITRVRKL--------------------------------------------------------------------------------GLNSVRAWGYLTFRG-QTSEKPEEIRSSRKHQWYLVDE--------------------------------------------------------------------------------------------------------------------------------------------------------MMMATRMRHVAMVAARATAAVSPVARARVSVAALRQASA-----------------------ALSTSTRSMFAQPPGGGASGGDDARAART---------------------------------------------------------RAPKQNRQQQQKHKQHQPRTTGAPGQRMNVAAATKGMPTPEDQMVDLVRNVLQSQQPAEASSPKRLREEFNEMKAELK--------------------------------------------------------------KIQQQIAAA---------------------------------------------------------APMEP----------------EEAAAEE---------------------PAP---SEKRTSGLQETEVTAADVFANAKGDINPDTEIIMDR--------------------TGHVHVENS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHVDYDIEDLKPITFQDLSRINIRHHAQHLRD---RMRAWREPLPEE---------FL-QIETRNYYHVGSQGSHIPEARKVILTAKVSQL-GLNAAEREKLLQLVG--------------------SR--------YRAATDTLKLVGRRYPTREMNLQYVKDLITVLVAEAKNPELQLAELQESA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Schistosoma_mansoni ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLYKTLLKSYYKTFLFLRK-NVTTSGSEKLKQNNCPHSS-YCEDP--------------------------------------------------------------------LSCSDYF--GLKNL-----------------------------------------------------------------------------------VNVTDLFQARVHLGHRSVLRNEYMKPYIYGCRQGIDIIDLQQTCSLMFDALNFAAHIAYRQGIILFMHQNKQMLPLIEKTAENIGEYSHCRKWEGGVFTNSS------------DVFHDS-----------------------VRLPDLILFLSTCNSISRP----HSAVRDAAKMLIPTIGVVDTNSDPRLISYPVPGNDDSPTAVRLFCALFAEAITRGK----------------KTAT----------------------------------------------------RDQLLKEQLDRQS-------------------------------------------------------------------------------------MFARLRNYERVISDAYV---INQKIHTGNTIFKNTRAGVVRRTRD--------QSHPLTYEQAKKP--HQIG----------LMKSWNSWNTSNLEGEDRYTSEVTLHDQFIRTFINGT---FP-LLVQS--EVIIKRQCNVIR-----VAF-------------------------LL--LKR------ISPGEVS------------------------------------------------------------------------------------------------------------------------------------------------FLIGYTEEMLS------------------------LILRCVVKLEV----------------QMVIS-KNDVIFRYV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDYNEKYFERLEML---------------------------------------------------------RNKSAVKKKRMK-----------------------------------LAPLQRGWTGKLLGG----QSVGPPTPNH-------PD-----FDCFVIESKVVATVTATKGRYRRFSVVVATGNGQGLCGIGKAKAL-NL-LSATRRAKLRASQNIVSFELKEGRTLWHVGYVCQWNSKIFATPLSEG----------------------------------------------------------------------AGLKCHRMIQTLCQVIGIKDMYAR---VEGSTTNYQAIAKGFLRL-L--------------------------------KQQKTYEDLANS-----------------LGLHVVEFAADRDM-YPHILASPACNHTNDFNKNDANEPGDSSVMTHSRSYELPERLPLLVEQNPTHRKPRKPIPEEHDSFLDDLIDVNDDTTTEINVSELLAAGERDLDTLMLGGRVPLKKSSYHHVQNTNSIGIKRKE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERHRYRNQQVVRRERNAHITLSENSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSNVIRYEMSLIIK-ALGTPG----IKAALKRHLKSMLENGAHLFNV-E---NLGL-RRLPN----VFHVQGERQ-YEGHYFLINFNAPHDSLNQIRMMDGSHHVHCQMQMI-ANLA-KSEIQITKR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLDEDM------------VTECIKGK----------------------------------------------------------------------------KIFTSGTTMWNFHVSLPTKLAQVIKFKQPFR----------TR------------------------------------------------------------------IYHYA---LQPKMVKYNESIDPEDPRL----------------------------------VKAVAPAQKWEH-------------TGSNYDELVSRIVGMMTIRGEREVAR--NVMRMTFREIKLI----------------------------------------------------------------------------QMRK------------NKSNATVI------------NPITVI------HEAVKNCTPLLLLQSVP--RGGILYKVPAPPVSSSVATHTAVKFILDAARGK---P-RDQRIWISLANEFMTASQNQG-----------------------------KAVKYKV------------------------------ELHK---QCEENRAYANFRSH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA----LSIEKKEYE----SGR-----KFLAQI--------MGYDPVHF------------------------------------------TPEQVNEAIEYLLPSSLFTKRARPVFKEP------H---------------------------------LVFPPQKQLQ------------------------------------------------------------CDI----------------------------NGRPVNSYF------------------------------------------------------------------------------------YTTHQNFYKIMNEATYK------------------------LEE----------------------------------IKHHADQSYFDRTTIK---PT-----------------------LKEV-HCATSSDFMSKINLMK-MINETISDAQYKQ---WLVLMKRLSEHPLSYLV-EEFIQRFKAQIC--GPTSEIKFPEPFLDS----VTNRKCVQ-AFGQKKNSF---AEVTLYMPGTG---DVTVNGARLLEVFPELGNREQIVFPLQQTSKF--FNIL----------------------------------LRIVFLKIQMIYNGE-YNKII-----------------------------------------------------------------------------------------------------------------------MLLLRRLYFPVRCHTGSLQYLQKALAS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVGVFNSGDYMREGSEIHEPD--------------------------------------------VLY------------KKLVITVKGHEPMVLKSYETFVKQVCDNLSIALKSETRNRP-TFFRLSMNKSPFIYKKQQRQYEFRTHYQYFTVDHITGCTADVFLEYIQRNLPEGVAMEVSKHRLE------------------------------------------------------------------------------RLPEHL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MICSKHTSNLF------QNVFRWASS-----------------------------------------QVVFNSTNIPDLKAP--------------------------------------------------------------RSLSAVAEKTAQPIILGHHVVTEE----CLTSLVEDKQYYETP------------------ILHLL--SRRNNVVATLTDCNG-RVLNGTSCGAEGFRNARKMSTVAFQTVGISIGLK-AKKLGIG----AVRV--VFNGLGSCRLPVLSGLNISG-----LKMISLTDDTKVHYGHGRRPKKQRRI---------------------------MSALFKHCRSVFSSSTGSFHKQLLNCPFVSVGLKCVNNGLSLPFASKNCFSLLGMSPTVNLATLAQMAICG-PFQKKRP------------------------------------PNKAMNSK---------PFIKGIVLKTFIRKPKKPNSANRKCVRVRLS---DGREITAHIPGEGHNLQEHNIILVRGGRTQDLIGVKHKVVRGVYDCAPVQKPSSK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNLFKPLIIKPNSGLINSLCNKMRLLSIPPLIPSEILYQREITPAKTPAHHNNPEIEKLLKNELCGYPAY-----------------------SARKIRRG-------------------FQDA---IMIRDYKRRQVSAHFCNLRIRLNAIRKNTILPQEIK-----------DLATLYISS-LPRDSNWTRILSRCIVTSRR--RGCKTRWKVSRIIWRKYADYNRMSGVL-W-----ARWGSNTRSVRRHMLWPPPRETSVSEYVRRYHKNLADV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHSALYKFPLLRNLNLGRVKFQISHSPSGNIQPFVCQSTQPTSLSDITFLPGPEKPSTWWPHQPLVPGRRVVKLYPVRFRNKLRIALVREGCS--NRPFFTIQIK----SNL---AESK-KIGIEQVGSWDPLPN-------IHGE---QLIALNFERIS--------YWIG-MGAEPTVRVAELLGLCGFLPVHP----------------------------------RSYLMAHRARIAMAKYLE--------------------------RLKQKQDEQVTDDITLKSGDTNEGEIVVDNQKDDTKEVDVDLRVDSIWRRGNEPPHWWYYGLR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVRYWKHRGLKIFKNIEPHIQKYFPYHKPELGGISPQHASITGKKAKVPFDYAIGQIVPFSQSLTSSFPDIVKVRLHKLCLNRFLM-KYFYQTATYWVHTQGFLVNVGDIVLIEKADPPMA--FN-TMYKLKKVEFPLGNLT-----------------------------------------------DPVTG----LRSEGPE---------------YSIETLRSILNREKC------------------------------------------------------------------------------------------------------MRVFATLGIWPTRLKESASSLLIPGFLNLKPALSVR--------------------------------------------------------------------------------------FFSVDLNG--------------------------------------DDDKPVD----------IPDPY-----RKTRKKCFI---CEK---NIPLDY---KNVRLLSQFVSPY--TGRIYGRHITGMCIPMQK----RISKLIIRSRQFGFMPFESKESVFIAD-------PRISFRTR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MYKVIKPFQVAGFYCSNFTAKYNQSSY------C--LQELFANPQIHNLLRL-ITYIDS-NTVHQRS--------------YRRAGKES-------------IKLLSDAELNIVK-KYTAAFTEQKLQMPPVLKP---RTPVNSQIISRDSGLQGIIPG--NIKL--VFTDTTLKHDRKNRLIVVRESN-GDLRHADLSERDRTNQVYFPLSGRKLFIPMMFE-DEHLNALL--DQGSFLYILDRTCVQFEPDDPHFSRICHRVYER-VNHLAWTPFEKTTGSIANGLTNPLLLLRHTRYYGPLALYMIAELGSPGPLIYETLA-HQHYNRLGWIIRLVCLVR-------------------PSSPFTVHIKSNVDLIPPPIQPVPDYTKDVSKQNMSPSEISKLLDYVELFINLE--PLSKDKQVILNDYLQQARESIKMNIENQG--------------------------------------------------------MLGSRRERFASIFKRVKGMIEKGA---LDYEDRPLWYDVYKAFPP------RVDPSYDRPCPTT-------------------------------------TVQNIIYPEDCERAAFFKGQHRL---------------ETLNMFNLVDNR--STLSKLLRKCRKLREVHP-DLSSEEILSLAEKE----LKQDETTNKQNFDSA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPFLKGGRAAVTRTKK-YLE----AGRI--LL-----NDGVKIIVI--NHV----PGAEISHGCDEFIK---------------------------------WHLPPLQFRNPNVQ--IITFKNMFPTPFIKIYLEKNEEQVVNCAFRKNSDI--YDHLITLLGKPAPS--ESSLVNNLTTKNP-SSFG--TEFPRQCICELYGQMP--------------------CSSN--------IGKPK---LWPKLEYTLPPVDTE-WFKSATDISVTDDR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSRLIWPYYTCTFFRRQPQYGLKSWYRYFIPDSYASVGIWNSRLSNNIFRSISVR-DHGLEILRKINSGKI-VSPLDYDIFANKLDELDVMSLDFVEEVIMSYMNTQAAVDVRDSTSHAFIRGYLNFREVDRLLKLIESRSKTGIFVDFASAVLMMDVFLRNGEWNSAVAVSWELCLQEYF-SLENVRPLVFAASLFSCIKSIEHDSFL--------VKESQPEDDKEIEQKLVPYVRNPNYDNFFDIKRPKLKTGYTLLHLSHVLNSRCS--LFQTTPV--WNSLSKHVDSFRLMMRIFGLALSEQCDKLLVEIRKVDESAIQLGGLDPTVVKKLIRIVDTCETRSDDSSLKPGEPQ---VPSVSDVKSVQNELLRIQGGPQCTTQNFFK-VVEEFVFNGVINNSDCMKQELEAVSDLYGKFDEERRKEYTEAVKMQKSEKVVEKAKEKLRQILDREEQITYFQNGTKIIKDAWLAPRTRQEARWSRLKEWKSEISSQ------KEKQNDSSPV---------------MTLEKYFCSSANLPNKDPASDSDKLTEFLNKAEHSTIEDKDFCDNSQSSVYKTNDDSKSTVDPSPISNFQENSSGKDKFEEKRVVSSVSFVPWTMSLFLKEMDISKLLSERSESPE-------KSFPTLLRYSPFIQL--GNFRSRELIGVVIDNVDD---TDLYIDFGGKFHCVCSQPA------NQF-YPRGSLVCIRLKNPELTGKFMVNTKGVSIFEADATLLGPYKGQLVRTIPDEEKMITTNADGVKRWRSATDEDNVALEHWCLK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--------------------------SSVIGKFITY---------PENEF-SLFIEPFLKV------------------------------------------ELVEELKTFGDLSLLIRKPTINMIKDVINIRNLQKESFKKEPDSSKFVALARYCVPRFVLHGQPGTGVSVILGQITCFAG-REKWIIFPFTSCENFLEPSND--IAPSNDYHYNQHRENFVGDAFDFPVRSAEW---------LKVFLQLNRPL-LEKIKPVVSRQVEWTKKD-IMPEGTS---WVDLINFGVARTKY--------AT------DCIGILLREMRLLSSNPGG--------------PPCLLVIDGVNSLWCR--GTLLKDKTLSVNVTTDRLAIVHHLKRALRGD--WRH-GVIVTSTNIRAAWPTD----REQ----------------------YTPGYLL---------GK-------SGFEYMDPF--IP---------------VLAENY-------TPTEINALLRFYAE-----------NNWLTNPAAFTPNG-QAELIFL-SD--YNPLELSRLAAEW---------------MTLQLTCRIPRFCGTTRHISFSPVLFKQPFHDRLRSKRANPPPHH----SLPFYDEAPTDTFPSKQVDIVGQWGSTDSSI---------KKLRFRHGEFLKTIPTSFEKLHELYHLED-------------------NMWFHSIDIPLQHSEMLEFSQFVTRTKL--IPWIP-------ESYDSNPILSSYLKYLFSEELHSVNS-----KPVNIHDQSVNGLNVR---------SDYRRKKISMI--METVYRSFLSAGT-ESLVNELSTQIDERGTIEMFLKRLVDHKV--------FENEDVNEDVYEPVNETIVDVERCVHYRIRSELAWQLRGPFPLKPH------FNLDDPICFLE---------NPIVC--------NYRPEAFDLQLVECYNFNCLPFARTIDFSEFARSIAGYWARTPFWEGDPCEFGLLGVLDLNRSECVRNEIS-----CSRLPDNVKNNILIRHGIAEGILTAFAWASAQAYNQGFTLYNELTYPFCVQLILMDGNYIQLLRFQLNSITSLWKAED-SMLP---YNLAWYSPRVELC------------KLQSDL-EHNKT---F--TVNNEAISLLTSAMLHPVDKITSSESLRPYLADGIAPRNYLIDKSSAKHLIPSSEEDNYHEKFGDISRLQLSETERKALKSSGELTKSKKSTRLYTSKRPHPNDIFFFKLTDRKTLINEIKEEMPDFGGPFGRVPEPYDSKLKEYQASKRHSQPRLRVQPPPRRWR---------------------------------------------------------------------------------------------------MAILYSSIFSRFHANFNHFKCLTATPFRSANTKQLKRSKGNSD--------------------------------------------------------NLESVDTSGDVSDYAKSTNI--------------VTSKDLLSDFIKEYRPDND------------------------------------------------APTTRF------VDLPSPANVNIF-----THENVLPADSCNSLNLIFDAVENLEASLFSC-ALPNNQFEEWLKWTVEKKMWSFPINNEQDWNSELDVP----------FHEHVF-LENHLNKE-H---------------LKCKPLAS-FLELVCTGLSKNPYFSVDDKKQHLEW-FTQFFDDKITRINASIEEEEHMTNLEKISRGTST---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTSLYAKKMTML-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGRIFRDVGKQ---------------------VDSKSMKVVRIMSELP---RPMILKDYYPPLEE-YNNILQKLRYLGLFRNEHAD------------------FREEMARLRQLRGK-GKRK----------KGESKRGLAQQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRLRPSLAFRASLLANTGRRNES----------------------------------------------SSLDCHQKFLPL--------------------------------------------------------------------------EIRGLNDPKSKDNKQMLFKEVGLLF-----------------------------------------ILHNNNNNSETS--------------------------------------------------------------HFARKIPRF---------------------------------------------------------YRLDK----------CLASCATFHHSLV---------------------PFR---VRQG-----------------HCKNLSENEGLPPEK--------------------YANTELMKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNFLHLTPSHIKKHCDALKK---FCTLWPSGLSSNETIEKYY--PV-VIVNRSYVFASS-NIRDPRSRVVTLQIRLSNL-SLDEHARRKLLRLAM--------------------GPGPGRNTATYDWNTDILELTSERCPTSKQNSDFLIYLLTVLTMESKKTEKWEIDNPEYDW-AQFD--------WDKSETRRRLFNLLSLRNNEQVIRNNQRKESDFTTEFESNSAIVQYRKALKSIWSKNDILNGDQWVKRPDPPKYRHGRLRPIRNVPFVTVPGADEKNNLEEYTSATRNLFGLDTEIQQSNV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Sphaeroforma_arctica --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEDLVAAKVHLGHHRTLWHPKIQPYLFGVRDDTHIFDLEQTMAHLRRALDVVRRVAHAGGIILFIGNRPQFEKVIRHTAIQCGEYYVTKKYKPGSLTNSV------------QTLGAE-----------------------IK-PDLMIF-ITLPV---S----KVALRESYYSVIPSLGIVDSDQDPTQVTYSIPGNDDNIESVELYCKLLKRAVQEGK----------------LYRK-----------QGMDMGDFAVDVHDEVQKLKTMSQKSKVHLDYPEEFVEIEEMVLKKAARDRDGLE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALGYSTGKSY-TP-DLSVDKAFRRAIRKLVHVRRYNDHTITHPIYVKFKKTRLYLRPSRVG----------------------------------------------------------------------HGTVAHEIVQDLCELAGVHDISSN---IVGST-IPLNIVKAFFIA-I--------------------------------SKHRTVEDIAKG-----------------RGRNIVEFKRSVEV----------------------------------------------------------------------------------------------------------------------------RG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPTYELALLAR-NNANV-----VGPLLLRTSKLIQNRGGVVIKV-E---NFGQ-QELPH----RARRHMEYF-THARRLGLQFTVGTEFIKSLQ-----SALAANTDVIRYTFI-KNSPVHKHE--------KKMFHRCK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLDRAK------------RMELLQKSKDA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MCSGHHGYPQALKLIRPHLSSRPQARTVLRMSSRKAVTGTQPSSYTHTTLYNNLR-TRVSARVYSTEPLAAET-----------KDASDDNNKNNSKHKATAKGTNNGKATPLLNALDGFNMKNLLNEDY----LSP-----RAADDVRDVKQRRDYDPNSEPYELECKVDTRKGTVFVSGLEKTTERVVASIFPPEKQADGTMQVTNESIRKEMQYWLPEVYQGDPTTPSLRPTKLRDHYEPTYVEAAY---------------------NLPDEYYADSDDES------------------------------------------------------------RDDRHPEDTNPKNTVKIE-------------NGRPVSQAY------------------------------------------------------------------------------------FTGYAEFYDEYYKLEEI-------------------------------------------------------------LIRMGQKKYPISPPPP-------------------------------Q-LLAVNAPFLTQKMMEA-LIGAELRAIHYRR---MIDVLNTIIKDSRYPYV-LDLLMPYLKP----GALDDKKVKPKVLDE-----KGRMYAT---GKRKAST---ARVW-ISRGNG---KMKVNGQPASIYFKRDSERYMLVHPFLAVQQVGNFDVMAT-----------------VTGGGTT---GQAGAIRHGITRALYYLNPR-FKGTLRAEKVREKTKLSREI-NLVTRDPRVVERKKSGQKKARKKFAWVKR--------------------------------------------------------------------------MHTKYRMWYHLGCVLYTKYQS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLY------------LRQSIKVSGIDHTILDSFIVYIQRLAKAFNIEVSGRVPLPT-KIKKIVLLKSPHVSKQHRRTFAGITHRRLIQIYNCSDETLDFFMDTLTDKMPPGCMMSAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQRKIAKIKLS---NGKRIVSYIPGGPHNLQEHSVVLVRGGRTKDLPGVKYKVIRGKYDL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IRKNSESPRKLR-----------LFAEKRLGS-LPRNSSIVRVRNRSLLKTKETGRGIIKTLALDRIILKEKITEGNIPG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAASARINY---LVDHMKRN----PKDLHSRRGLEQLVQNRRKMMKYLRRTNLER--YVHCIDVLKLRPLPP----------MGQKDYR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFKILYLSNCFPPSHLSAFSFLQLRIH--VSPFS--VVA----DGR---CKRD-GKFIEHVGTYEAIPN-------KNME---KHTMMNTERIK--------YWIS-VGAQPTKPVARLLAQAGLIPPPPGFEARRLMREKLIDNPTGTTPFQKWMDELPQGERKNYLKVLNHKIRITDAKGRCGYCHDVGHGKDTCPVRKEDRLTYKSEDSADAKTPTKSKDLPKAGSSIDTAAQETETTTDGKDAGSKKSSDIPKETEAAQKDTGSDKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QYIKKTKRYLCHDENELCVVGDEVRILACR-PVS--KR-KTFVVDQIVNPTQRKV------------------------------------------------DLTG----KLHTQWS---------------------------------------------------------------------------------------------MNAVTIISRATRGARSALNSEALIAHRVCYTTDSSSGDNNTRKPPPRTTPPQSAAHGPNSAGKPNQATPNQPRPSPFFKTNSPPQQGNAGAGANPGNSGPRKFTQFPGNTDRVFNRPQGGAVGGVQGGSVSFSNPARAFVPPGREPGAGGAPNNFNLQNRGGFNQKVGTQGNPGAGPGGYAYSQRSAQSNYQAPSNRPGLGPPAVTRANGGV------------ANKRYIK---VQEKKSCPI---CSN---EVEFDF---RHVNFLSQFVTEH--SGMILPARLTGVCAKQQR----KLAKCIKRSRAMGLMSFTGPTPGIADN------LPRMG-----------------------------------------------------------------------------------SMIFPEYIGHKISVYNG--QIYRGIKIDEDKVGLKLGEFIFTKKRAIY-KRKKTK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVAIPP-----------HDYPGRSN-------------------------------------KVKSIKFPEDKLRKKFYDSQVGKG--------------TEATPLYESSAR--SICDEFVKVQKEMMSKKM-SEAEAFAEAETIINQ--RMKNTSPVSKAGKNSQ----------------KVIHDLLQSIKDAQANKMLGGAKGMLSNTTSGFMSTTLRYIKIDLF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNSSAARPVLSVRARIFQRTSTATQIQTRVRACHYSDTPNKGGGGSRLEELKRRLEAQRNAAQNSRPAGRSNKPATSGPRPPPRASPAPPTAGEQRKA-----------------------------APFFRSSEPQSGQPPPPKSYFQSQKPAFGSANGNASQNSAQGNRPDGMFGSANQNASNKSSQSNRPSGGAFGNIANQKPAFGSAKQNASINSSQSNRPTPNQRPNAFTNQNARVQATTPESTTPFNQKPLFGRLNTAPNSQSGGSDVSSLFLNRNSAATPASQLRYTPNANRGTGVFGGKDRLAQPAAVAPEEEAAQHKGGHNHDAPGGVVPASNEPIEIGNVPLTTPLAFKYHSAGQIGQFYEWSSED-----DEKRGKKAKEDVVWPK------------------------------------------GMKDQFKLFGKNSLMIRQPALEVLAHIRNHERTENR----------------DKKFGVLVNGMRGTGKSATIAHVAQTLA-DKGHVVLHIPKATFWMYEADR--VVK-SAVHPW----------FDQPFDATDL---------IDYFLKINDHAMLK--DIKLKHKYEIEGA--AAGPGTPRDSILDLARMGAGPLDLEILEDYPPAR------EVLPALMEELRLMT------------------DKPVLVAVDDFNAFYNV--SELRDNRN--RRLHGLHMAITQLVIRLLDDKYKLAR-GTLLMGLTNTGIKTNT----KFS----------------------TEIKGMIKEAAAIDPFNS-------NTIKELPEL--VK---------------VQTRAF-------TEKEVERFLLYHHS-----------CNKRPDTKDLRETT-IAEVRMM-SS--CIPEQVSKLSVYM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKQLKRP--------------------------------------LKGPSTA-KYYPDHIEHFEKATLEMKRDLMFTDESEA--------------------------NTILHF-C------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLINGFSRTMRPWCAHTCRSPMPLQL-------------------------------------------LHTRTYHATSTVLGRRGRLYK-----------------------------------------------------------------NKIDRTSKGITPERYDAARIDTVRK--------------------------------------NVGTFEDPLIREKLD----------------------------------------------------------EKLDVDKNDWESFGRVATVINSKGKLIFDAESD-------------------------------------KPTELPDFQNATDPEAAIKKEMYKRSHF---------------------------VRLG----------DHDDDDNDSIVIDVPSVEAEML--------------------YADMDKLKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDMGFVSHAHITRFAERSKD---FITPWKLPAIEN---------VV-RISYRNNISAA--KETHKVERKVVLEVRAADL-PLTEVGIATMAALTG--------------------PR--------YNKDKKVLKLTSVRFDNREENKAYLLALLEKIVRASQ-----------------------------------------------------------------------------------------------------------------------NEETQALVEY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Strongylocentrotus_purpuratus -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAYMMKNSSIWRALIWQQKQIKHSWPDIRVAQLCSHAQP-QEVTPESSLEGETRRDTVDES----------------------------------------------------LNHDDFF--GVSNL-----------------------------------------------------------------------------------FTRTELFESRVHLGHKEGLLDQRMKKYMIGTRREQCIMDLDQTTPLLNSALN?TANIAYRNGIILFVNRVPQFAHAVEEMARACGEYAHTRHWQKGCFTNAQ------------IQMGPG-----------------------TRLPDLIIFLNTLNDVFSQ----HQAVVDAAKMNIPTIAVVDSNCNPNLITYPIPGNDDTPVAVELFMRLFKESVLLGK----------------QKRK-----------------------------------------------------------ELEETPV------------------------------------------------------------------------------MTLPGINCVNMLRGALGIQRSSF-----RLLQTTAVCHKV-VAGRVRVSK---------GEKPVTYEQSNPP--HYIG----------VRKGWNSKHTANLEGEIGTAD-RVLEDLFIRKFMYGT---FH-NCMAT--ELVIKRRANQIF-----IAA-------------------------IM--LRN------QAPQKYY------------------------------------------------------------------------------------------------------------------------------------------------FLIGYTEELLS------------------------HWFKCPVKLEV----------------QIVED---RPVYKWI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVRQMQSVSQLCSFIARRLVIGPNVSSQTRLLSTSQCQPRDERMLVAPQSFMVQKRYTSWYNTLTADQL------------------------------WKGMLATTGKAARKARGKRP-ARRMKKDLNRGQMV-----------------------------GEGRAQIAWPGLNAPVV-----------QGKEVLTIQKKLPDPEK--------EERLRLMREQWDKKRKRT----VPPEERGWTSKSWGG----RTLGPPDPIP---GENFEG-----FDSRVIHVRRVFNMTGSVGRKRSMSALVVVGNGNGAIGYALGKAP-GV-IAALRKAKNKAATNLHYIERYDDHTIYHDIETNFEVTRIRMRKQNKG----------------------------------------------------------------------YGLRCHRVMKEICRLAGIKDLYAR---VYGSV-NPINLTKAAING-F--------------------------------VNQETHQQIADR-----------------KGLHVVEVRPERGS-LPIVVASP--------------------------------------------------------------------------------------------------KNKDTRTDVDEEPWDKELP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LEWKEEKPRKFENNFIREGTMIF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPGYEAALIMR-VMRR------IFGFIRAGGAAGADCASPPRACGE---GVGSDMPSSLHACCKRKSQAKGLTRASQYFVIDFDGPPTIVEPLR-----EYFRRDIDIIRPSLLNRVSEQWPED-------------TVCE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPHDER------------YNPVVKSAKKLKVNVLQELEDANIKL---------------------------------------------------MALSTKFYGLSSKRELW-------------LPLFTQVR----------FS------------------------------------------------------------------RYKPT---YVPPVVNRQSYEDGSLPLDI---------------------------------STPVKAAVGDIT-------------SAFTYDPLVHKFVNVMNKKGQKETVS--KIMEKTFEIIKSK----------------------------------------------------------------------------QVEK------YNRASEMDKSSLET------------SPRVIF------MKAIENCKPSMGLVTIK--RGGKNYQV-PSPLKDNRQRFLAMKWILQECEKK---P-LKMHMPEKLAQEFLDAFHDQG-----------------------------NVVKRKH------------------------------DLHR---QCEANRAYAHFRWW-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAHGGRLFRVFGGKLLRISHHSRAL-QVIDTQQWKLFSTDVQP-----------K-----KEKKQKDSVAAVIAAAQDRRTAY-DTL----IQREELSYE----RGR-----RHLANM--------MGEDPEDF------------------------------------------KQEDVDRAIEYLFPSGLFDKKARPMMKPP------A---------------------------------DYYPPQKAAQ------------------------------------------------------------FGP----------------------------DGRPFDALF------------------------------------------------------------------------------------YTGKPNYYNLMHDTVNE------------------------ANK----------------------------------VIAKEDEMIRKGILIH---ET--------H-----------------P-VNLARSEWIDKASVER-IVVEALSDKEYLN---FISLLERILQLPYASEV-SDYIHKFRRELV--AELSKEVISPILEDE-----NGQPYSK-GDAWRKSAK---AWVTLKDQGKG---QVTVNGMEFLKYFTWVRVREQILFPFNFTETLGRFDVECE-----------------VVEGGRT---SQAGAVRLAISRALCSFVDQQKIEQM------------RQA-GLLTLDPRLRERKKPGQAGARKKFTWKKR-----------------------------------------------------MIRAFGRPLSVILSSEPFLVQTVLKDHGSFRFLSQLSRLQLPKSGLSHTSCLSQCSTG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPLPTPTLVSQCTRLASSPYTTSNQPTQQEQANDEEPED--------------------------------------------KLY------------KWIELKVKGHEDAVLESYTKYVNLAASELDINVDSIAKPFR-NIKRLTLLKSRHVYKKHRVQYEMRTYYRVIRLKHLTGSTASVFLEYIQRNLPEGVAMQVKKCSLE------------------------------------------------------------------------------RLPVHLQSP------------------------PEQLSEEDLDISASSSSSSSSESEDEAQDITK------------------------MFAKLLQQRVLQLSTRLQLCNRQLLQQPCPSVQRRMQATCSHHMWQQSPHHHQGLLQTTISSNLSSC---------------------------------------NFHSLVSIRRLQQDTTATTSATGASS-----------------------------------------PIPDPSSGGHSLEDA--------------------------------------------------------------AIAEETAEGNETLFEDEHGSNMFIAPSSTESLIFNGIPYDQLP------------------IVNIK--ATYNNTHVSVAEHTG-RTVARTSCGTEGFKNAKKGTAIAAQTAAIAAATK-AVDKGMN----AVRV--VIKGIGPGRQTSIKGLQMGG-----LDIVSITDNTPVPHN-GCRPRKARRL------------------------MFEIFTRMRPLLSSACRMCHHHSAVKGVSFFGSMASSLQASLFKPTLQSVRS------------ITINQLHRRG-PFRRKPN------------------------------------PNMTFAMDKR-------PQMKGVVLKTIIRKPKKPNSANRKCAKVRLS---NGREVVAFIPGEGHNLQEHNIVLVEGGRTQDLPGVKHTVIRGKYDCGHVIKKK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFTRSY-------------------YADW---KMIRDVKRRRLVKEHHRDRLRFNCIRKNTILPDEIR-----------EVADQEIAT-FPRDSCHVRIRDRCAITSRP--RSVLKRWRLSRIVWRSIADIGNMSGAQ-R-----STW-----------------------------------------------------------------------MAVADITAHLRRTIISFRNTKRFDTICRINQVRAVSTS-----------------------------LAMSNSAASGRSGHQVGDRA------------------------------------------------------PSSTSMLPRSPMHFSRGLASRAHMKYNKRKKEPVDRFG----GLDPAQPRLGFEK-VKELETANENVKKLFSL-DFGTGNDLHNMRRKLSQDSVRDK--------------------------PDEKDDLAVKIATITEHIRA---LAPHVENN----KKDSVNKVRMLNAIDRRRKMLKYLRKRNYER--FERLLVELNLTWSPPPEFYRRKT--RRSMEKKATVQEAYAKRSLALKEFETRWRQEQLLEIAHLKEELGKELTEEEQSLLTKSREETAV-----------------------------------------------------------------------------------------------------------------------------------------------MPVMLRLARHGCT--NRPFFHLIAI----HNK---FARNSGRALEQLGTFDPMPN-------NHNE---KLVSLNVERIK--------YWLA-IGAHPTPPVSHLLGLSGLLPIHP----------------------------------RTYVIARRARHKTATKEQ--------------------------------------------------AAAAEAEVEGTS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSGAARKILIGQVVGT--KMIRT----AKVRVNRLHLDPFVT-QYFPKRSTVFAHDPEEAAKLGDIVLVKELPIKKS--TH-VKYQMERIIYSLGNVT-----------------------------------------------DPITG----KKCDCYS---------------YWDDDKSTEDAVSTPGSTDGDGMEEEITRTIGEERELKTEGTPV-----------------------------------MAAYTTSRNLVR--------------------------LTTKICSLQASLRLHRTFPILTTSTSQQARSLCRSS--------------------------------------------------------------------------------------E-------------------------WKNPHKDRQQVQ--------QTEAIDC----------EEDPY-----KLAVEKCIL---CKY---QVPISY---KNVQLLSQFVSPN--TGRIFGRHITKLCEAQQR----RVTKAVKRAITMGFMPSQYRTTQFLKD-------PSLYDVRYTGSIAIGQYSKLPDSNISEEELLEMQQRAEEEAKTTQS-----------------------------------------------------------------------------------------------------------MSRHLRFVARTVFVKGG-------------------------D--------VDGAYRTLNNSLNRDG-----------------------------LIESVRR--------------------------------------------------------KRYFEK-------------PFQ--------------------------ERRRKEYE--------------------------NMKKIYNQEMGRRIQ--FIMRKNRT-EP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WPV--------------MMMQRSRQLLSTFSSIRLSLGHSGTGRKLCDSLHSRG----------------------------FQEEEVQRLLKR-ITGLQL-EKVFKPA----------------KQTLEAP-----------SYKLVSSKKLEEMR-QSAEEEARMRLQMPPVLEE---R-TPIDEVLEEDEGLAGL--D--TANV--VFTDITYGLNDRKRFVVVREPS-GRLRKATWEERDRIMQIYIPRERREVEVPPLFH-DEQLPAVF--ANERHEFLLDAACVQFEPDAAGFLAVHQKAYED-LAS-----------------TEMYDVLRSTRHFAGMAYYFSKHKRIDG-LLTDMIQ-RDLFDDAVDLIRLYNIIH----------------------------------------------PTSPVAQEAQTLNLDSIDLIKASTGSR-----------MLEYPDGYPDGYLHG------------------------------------------------------------MTSLSRLEKLGTGFTRVRDLMRAGV---MKEMDKPLWYDVMATFPP------RDEPTFKQPTSPE-------------------------------------PLKELLYPEDKQRAKFYQTYAGQQ--------------TLDLTKHSSVKD--SICNRYIQTYHDQEAKNE-GMSVEDLMVATEQ----ALAAQGINLRRRGVPR---------------MQARKETPSQERKPELGGLAKLLQDALAKEGPQTR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------MP-MKGKF-PLRRTIR-YLE----QGKI--HL-----RDSVKILSI--NYN----SFGKESDGARDFVF---------------------------------YHLPQLQYKNPNVQ--MQTFKNITPSPFIRCFLNEGKEVLIDVEDKTKDDI--VEHLNKVLGKSERVL-ATERKAMERSSNP-ANFG--RTYARWCICEVPGQFP--------------------CP-----------KVVP---MPNEMKGKYRELKEDSLRAPEALVQRADTPTETAV----MFGIVRTHLSHLRVVQRSWEPISATGSLQIQQVRW-RKRRT-----DPKAKSKIGKVREPTPWDPWERAFLVEKIPH---YNSTMN-AVRRLFNAELERKKDETAEGLSSVEQERE-EEEEFRQLLKWNEQENAKINARRKEKLA---------------------------------------------AKAKENEEENLQRLLRKEEQEAEETERMRQLVLQEQEASKTFITMESMEAAINEALDNPKNYNFLMKKSGEPI----------LPEDT---------AWEGFKQRTVKAKDEELVEGDGDHIKSAEN-------------MAALMKPTFLNKLSTLMATISRTNQLRCSCNMRTSILLQSK---RTLLSDAYHGDNIWMNRERIV----VDMD-EMKINLDRAFYDLKEPVMSVELHKFIDNVYDKE--ELDVAEGYLNSYRHSPVAHHLRPSTVHSWLRLCIELGHHKQALKVLQNKRDYGLFPENFTYNLLLDTFLKADDIKGACDVAIVMMKEETLEDC----PLSQLLSLNACHQYL--------------------------KMGDIP-------------EDERWDIGMTLADASRRVDGI----LALSYHAIGYAMTGDMNKAIGVLQT-AS---QDDGSKIAQEALDHIATIFQ--------------------------RMEDQNTE--------LLNLYKTTTETLANQGKVTGDTLDS-LLESEISTGL---PDLERKDAEGYTSILETWHGEHMEALETQ-RIAELDVEREAKEKRLDELLRATGGIKYWAEKIDEA----K-------------RRKAASEVEI------EHR---------------------MAAPIVAMIRQRALTLLSYRSHRVLFGTKRHYS----------------DTPSTADGENLQTVENDTDKNTPGGSKLTGFAE------------AFVRHAHVSDPEPSGDLDSASPS----DDDVPFAELFRKSAHVNL--GAAYNQIVYGNIFHIVED----DLYIDFGGKFHCVCKTPAE----NSEK-YHRGARVRLRLKDLELTDHFVGASRDLTLLEADAELLGLAKQKQK-------------------------------------------------------MAASSCKGMLDIGFTMLAAAARNTNRSTSWRCIRCLSSGVAP-------------------------------PPPPPGTSSDTIPTPDNTQSSQPQPQ----------------------REDFRTSESNPVNH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T--------------------------ARHLGQYYTI---------PMADVPTVFPIG-YSA------------------------------------------RWHKLLKPFQEASIMIRKPAVEIMDVM---RHADYT----------------NPPIKYLMYGRKGSGKTTCLNHILHSCH-NQGCLIVHIPCANSWNVNNKWDFLD--SVSHEGM---------YDQPALSSEW---------LKHFRSRNEHF-LK--KILTSKCYEWSKRE-QTEAGEP---LLSVVDQGLNRPKN--------AT------DVIGVVLKELRDQSSS--G-------------KYRLILAVKAVNGLFAEM-TNVRKPGG--YLIPVNELRMAYHFKKMLKGQ--WTN-GAIIMTVDQHNCHQAP----KWD----------------------FKPLHLL---------QK-------QGFEWLDPF--VP---------------VYVENY-------SDKEFESCMQYYIS-----------KQWIQMEQAKTEEG-KLHLKLL-SE--SNPGSFERICASL-----------------MAAPLRLSAATCASKLSRFQWILPQFVTKKLNFSSETAVAES-----NEPQY--PPI--PP-----PKDSKGELIRIA---------S-------EPVLAAETPAEMIYALTKKY---------------------TWNYKIHPYSYHPGFVDFYKHITKTEV--VEGFPDTIE---SWIESEEVQN------LTNSVSDIAR-----NVLLNDHAMTYRHKQN--------TVWRDRDVGNQL--CKNLIGCIIPYLA-ASNKHLMEADVDFDVEMQSFWQR-GSHRF----------------------------------YQFLGKPLLTVRTKRPLREF------VEQDADLCQGS---------IADWP---------YDPNTISI------------FKQSG---NAVCF-PGFK---H---GAGHLNAHTQLYL-----------T-----EERRSKVEEKSILPDILQGQGISTSFAWLNALALYQQHCCYKDIPRPLTCQTIVTDGKYFSFYCYQLNTL-RLDDLMG-EGNDL--RNVCWQVRDVPLF---------------SAV-EEDQV---V--DFNEDVVKMMVAFLANPTIGEG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQNSLLSASQLSRFCLRLKQARCARCIHTATRRWAEDDGNDDLGSTSDSRGKKKSAVAASDLLNALSDLRVQTTGDKQTSLNRRKKVSAAANFQRIVARAEQRRDGAEGEGEGEGEGEVEAKGIVAEEEKLPGLEEIQEMTMEAAKKVAEVYPERELVESDLLKELRRHDEATAAGERGEA--------------EGIDSVLSGIRVQRQTSLEKRQEGRDVMSSKGGQQGIADQFDPNYSSDGSMRPEFDDNMDRRRMGRGEPYQRQRKR----TLFDRQRLNIFSPATETDVSEVKEEGTSIWERELDKQLRELSY-----STMHNGFEEAMKLTEEGKIWKYPIDNEQGMEKERKVA----------FHEHIF-LDHLLED--F---------------PRRAQVLD-FMELVLIGLSKNPFLTVAQKHDHVAW-FRDYFWQK-EEIFLKLEKEEKVSVG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSKYAKRMARL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GARIFGDVY?P---------------------TSSKSMKVVEMMREEPRQMRKHIV-DYYPPHMQ-SFKLMGYLRYIGLYRDEHAD------------------FRDEMKRVQKMKGK-APPK----------KGEGKRAMKRK------------------------MAVHAHPWRT--------G-----------------------------------KSLFDLLNQLPNFGVGRIVTRTRWQ------------HWRPDQPSYIRITRVKV-DCESL---------------------------------------------------------------------------NLGQGEAWGIPTMRGYSRDGMEIKVGAWWKREWKLIRKSEEDEFCAYQPK--EEDFHQVPNKVAMPPLLAAMLKEEGVIKGTEVEE-----------------------------------------------PLLLDIKTSRGYRHRGYQVPGANVLGKRIGDFEIPR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVDDQEWAGV---------------------------------------------------------YPTAA----------------SFKWSAV---------------------PLP---LRMG---------------------YPVRRGIPPHK--------------------FGNLELIKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNFLHLTPPAIKKHCAALKE---LCSDWPEGLETDADCERHF--PL-ETVESDYTFVGS-SLRHPQSREVTVKVKLSEL-SLDKHARWKYIQLVG--------------------DR--------YDKETDIITISADRCPLKKQNYDYCMYIMSVLYHEAWICEPWESEITDDDM-EEYV--------WDISPSKTSIISTIARIRNKTIGNG--------EVDPQLEEEILESKEVQELRDSVLDIRN------------------------A------GESLDNLERYKEAVLGIVRSKTTLASS-------------------------------MSANRVVQA-----------------------------IRPHI-----PLIK-------------------------FRAGGGIRRVIPAGAVTATPHPNS-----------TSSLKPPSTRRSDAPEF----------------------------------FQLHPKYHRTILTQEEMEYINR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------G---------------------------------G-PD--------------------------- Tetraodon_nigroviridis ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTSRAFSKCFLWLRP-PRAPTVGYACRGCRASAAA-VVNPPQPQVGGVSEKIMDLP-----------------------------------------------------LKKQDFF--RVSEL-----------------------------------------------------------------------------------FSLKDLFDARVHLGHKRGCRHRLMEPYLYGCRLEQDIIDLDQTMEHLQLALNFTAHVAYRGGVILFVSRRRQFGHLVECTAKECGEYAHTRYWQGGLLTNAN------------IQYGPG-----------------------VRLPDLIIFLSTLNNVFQQ----HVGIRDAAKMNIPTVGVVDSNCNPSLLTYPVPGNDDTPAAVEFYCRLFKMTITRAK----------------DKRR--------------------------------------------------------QMELLHGLT---------------------------------------------------------------------------MAASLSTTGNLRLWSFLSKPGLLCGSS---AVRSLHVTAVCCKN-RAARVRVGK---------GDKPVTYEQAHAP--HYIG----------HRKGWLSQHTSNLKGEGGAAE-RVIEDMFIRRFMFGT---FH-GCLAN--EIVIKRRGNILI-----VCA-------------------------LM--LQK------LPPYKFY------------------------------------------------------------------------------------------------------------------------------------------------FLIGYTESLLS------------------------HFYKCPVKLEI----------------QTLQD---KPVYKYL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RQRDEWEKRRKMK-----VKRERGWTGHSWGG----ISLGPPDPGPN--GETYED-----FDSRIIEVKSVFNMTAKEGRKRSISCLVAVGNGNGAAGFALGKAA-DR-NTALRKAKNRAIHYLYYIERYNDHT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPRYELALILK-TMQRPE----TAAALRRTVETLMERGAVVRDL-E---NLGE-RLLPY----KIKKHNQGH-SRGGYFLIDFYASPNIITSLM-----DHLHRDVDVVRPTVL-KADEQVSKS-------------KCC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLQQ------------------------------------------------------------------------------------------------MAASISGLLKPW-------------MPRVFFVR----------WS------------------------------------------------------------------RYNPY---YLEPEVRKEAYNRPETEL-----SAEEKQQLELAA------------------LRPIKAAPVGLT-------------SSVFSDPVLSKFTNMMMKHGNKVLAQ--EILTQTLENIKRK----------------------------------------------------------------------------QVEK------YHKATEEKKEEIEC------------NPYTIF------HQALDNCKPVVGLASIQ--KG--WKQV-PIPLTENRRRFLAMKWMITECRDN--KH-RRTHMDEKLSQELLAAFAKEG-----------------------------NVIKKKY------------------------------ELHK---MAEANRAYAHYRWW-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAASCVRSLSSFWGKCGRCNVGTSII-V--------------SP-----------VGLQGLHRRTCWSAAARRRKVAAAEGEKVGPEF----IRKQVEEFN----VGK-----RHWPNM--------MGEDPENF------------------------------------------SQEDVDRSIAYLFPSGLFETKARPLMKHP------E---------------------------------QIFPRQRAVQ------------------------------------------------------------WGE----------------------------DRRPFHFLF------------------------------------------------------------------------------------YTGKQSYYWLLHEVYGK------------------------ILN----------------------------------LEKHEDALRAKSR------------------------------PGGRS-SSLGTSRWLTREELET-LLVETVSPDDYAR---FLQLMERLLALPLGPGE-EAFVLRYRCQLE--AQSKSQAVPPLQRDQ-----RGVAFST-----AEAAA---PD---ASPSTV---RTTCTTSPSSRTVRRPA---RALRPGMQ-----------------------------REGGGRS---GQAGALRLATSRALLCFLAEGEAENL------------RRA-GLLTPDPRVRERKKPGQEGARKKFTWKKR--------------------------------------------------------------------MALRRQLCSLKRIFSGSTYSHRRVLNTCSSLTG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPRIRPLLPLTPTSSLHTSTLFLTGHSSITVTDEP---D--------------------------------------------TLL------------QKVLLLVKGHDRAVLDSYEFFVTMAANELGIKISKVYEPEK-DIERLTLLKSVHIFKKHRVQYEMRSYYRCIELCHITGSTAQVYLEYIERNLPEGVAMEVTKIAME------------------------------------------------------------------------------KIPDHILEP------------------------MWKD------------------------------------------------------------------------------------MSRLFFNANLVCWFRNICNMN-----------------------------------------------------TLNCTFLSSVS------IVCRQLSAS-------------------------INTNGICGASALQRTLFTGAVRLEDARQAAT--------------------------------------------------------------KSGESSKEFSQLPPLPGE----------DSPLRWAGTPFEQLP------------------IAHVK--ATYNNTHIQVTDSAG-KSMVRTSCGTEGFKNIKKSTPIAAQTAGISAAAK-ATAKGVT----FVRV--VVKGLGPGRLSAIKGLTMGG-----LEVVSITDNTPVPHN-GCRPRKARRV-------------------------------------------MAFFLGLRPVLTSLFQASWHASEWMGPPLHRTM------------ATLNQMHRQG-KPRAPPR------------------------------------SVGATFGC---------PQLKAVVLKTMIRKPKKPNSANRKCARVRLS---NGKEAVVFIPGEGHNLQEHNVVLVEGGRTQDLPGVKLKVVRGKYDCSHVVKKK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAARRIVCSGLSALYSTVYAPKQALRSC----------------WGAVEQVRSY-------------------YVDW---RMLRDVKRRQMAFEYADERLRINALRKNTILPKELQ-----------ELADKEIAA-LPRDSCPVRIRNRCVMTSRP--RGVKRRWRLSRIVFRHLADHNQMSGII-R-----ARW------------------------------------------------------------------------------------MFPNVAIRAFLKCSAGILRESCTVS-----------------------------------SVLAAKSWTDNSTL-----------------------------------------------------------LGPRIISVAGSLTPATPVRYYARAAKTKRTVPPSQLSDLPPTMLKMDYAA-VPLAQTTDEVIKRLLSL-ELACHREKLHLKTEQLVSKVQKD--------------------------ENDRSSMEVRIAILTARIRN---YQEHLQKN----HKDKANKRRMLMAIDKRKKLLKKLRLVRYDA--FEHVCEQLGITYTFPPEYYRRVT--RRWLAKKAFCIKVYTEVQKQKAEQRQKMKQSSASTNTDVASNQ------------------------------------------------------------------------------------------------------------------------------------------------------MVNLSSLLLKNYHGGHVVIRMALAGHKQANRPFYRIVAA----YNK---RARD-GKYIEQLGTYDPLPN-------IYNE---KLVSFNFDRIK--------YWIG-CGAHPTKPVAKLLGLSGFFPLHP----------------------------------MTITEAERRRAK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSVRRATVHAKWIIGRVIGT--KMQKT----AKVRVTRLVLDPYLL-KYYNKRKTYFAHDALEQCTVGDIVLLKALPDARS--KH-VKHELSEIVYKVGRVV-----------------------------------------------DPLTG----KRVAGTE---------------FLE-PLNDLALSPDEDVQLSETLQELHISA---------------------------------------------------------------------------------------MYTLRVLQRLKPGLSPHGSTSLRSLTVTSDVAKQ--------------------------------------------------------------------------------------------------------------------------------------KDDMLVK----------MENPY-----KEPQKGCVL---C-----NVTVDY---KNIQLLSQFISPH--TGKIYGRHFTGLCGVKQK----QVAKAIKKAQSMGFMSVTHKHPQFMRD-------PNICQLKQ-------------------------------------------------------------------------------------------------------------------------------------------------MSRHLRFISRTVMVQQK-------------------------N--------VDAAYKTLNRLLTQDG-----------------------------IIETVKR--------------------------------------------------------KRYFEK-------------PCK--------------------------ERQRRTYE--------------------------NCKRIYNTEMARKIA--FISRTNRQ-DPWLANSAHRLNLFYVANDVIQNCKRKNAIVYRTAFAEVLPDACMLVNLDGDRKVIKAVGRILSIWEERAVYSGSLITELKTALIKTESPPETPAEPKTPVESKGDLWSTIVAEFVPQALVDKLSRYKRSVEEVDLREKQLAAMRIDICNLENLKKLKDKAGGKKFSKDFEEGSAQLHEFIKLLNGHCKTGPPLMQILNNADIFYETQYKEVKIVANVSSKRVCHQKVVRGSPLRPAALDNDDNRMVEDMDLSEEEADSSVIADSAHAAPAVVLANLYPALEQRIECAPKPEASAPFPAGTEASKAAERQSAAPASDAAAVDGIDLAKIGSILNSLSSVMKNTGIDSLLAEPAANASVDACVPEQAPPTPASLVSSQSLPVAPEGRAATRKKSPASALIQALHKDMDLSAEHEPSFVSESLESKIHNFLQGNSAFNAFDLHFSGQPGATLSPGPGPDTQDGTPVRDEGGGTPTQDEVMDKAAAAPAAPGAYPKPSEPLQRAAAQNGLLYHYPPLSAPTGRPAEIAPGGDGGALTAEPPQAVNDGG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERFIVVREPS-GVLRKATWEERDRLVQVYFPKQGRQLKAPLIFQ-EDNLKMVF--SQDHHEHVLNLCLVQFEPDSAEYIRV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLQFSLWH-------------------------------------------------------------------------------FFRLYGTG---------------PQAFELSKSDFV--SPCQRFIDKYAEL---SSTPELAGDALFEETAK---ALLKDGITLRR-----------------------REAPFVSTNTF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MP-MKGRY-PIRRTLE-YLQ----KGDI--IF-----KNRVKILTV--NYN----THGALSDGARKFVF---------------------------------FNIPQIQYKNPWVQ--IMMFKNMTPSPFLKFYLDDGEQVLVDLEGKDRTQI--LQHVKKILGKSEEVL-QTEAQAKMQASNP-ANFGPQKYCLRECICEVDGQVP--------------------CP-----------GTTP---LPREMTGKY-------RAQMAASQE------------------------------------RG------------RKSRS-----DPVAKSKEDRIKVPPPVDPVEMVVLKERFSE---YQLIMK-ALRLEFKEEVLRKKYEEETGSLAEERARQ-EAEEHRALMEWNDQENARLLRLRIQRIQ---------------------------------------------REKEETERKQAEAAIIREQKQQELIKAKETEILQLQEEAKNFITLENLDQRIEEALDNPKNYNFAVDKEGRVV----------KQTVL-----------------------------------------------------------------------MTTAVKVKCV-----SPSFSAR---RWLLSAAYTDTRMWEAREPEP----QNLA-VLADTMDKTY-DRNLPVSSLTVSRFVDNISSRE--EVDQAEYYLYKFRHSPNCWYLRDWTIHSWIRQCLKYQARDRALYTLKNKVQYGIFPDDFTFNLLIDSYIKDGDFKSACSVVEEVMLQESF-DL----PSTRILSLYALSSYL--------------ASKPPLTVTEERALGASLLICGLKQDDCVGLSAQ--LLGNALLGKVEMLKGLHA--VFKGMPLF-WGR-GYLGRALAVMERAAA---GDVG--LSRDMLELTQDLLGDLSSALDASSSGEESSDADGETQQPVDKDDQAEQ---ARLQEYASRFQKLRGQLDSRGKVDSTPFQG-LVTALAQQEL---PSAEKPDLERYESRVQAWEAEKKQLIQRE--RELREKAEQEKAQRLATRAAAE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--------------------------LDSITRS------------LPAHIHSLFPLG-LPR------------------------------------------RYQRQIKTFNEACIMVRSPALEVISYL---KKTDNT----------------RPAVRYLFYGLKGSGKTMSLCHVVHFCY-TQGWLVLHIPDAHIWVKNCKE--LLP-SSYNRAR---------FDQPLQANEW---------LRNFKTTNEKF-LS--TIKTKHRYVWTKRE-STNEGST---LGELVDQGINRMKS--------SS------DVVAAVMKELRLQSGQPES-------------NFRLAVAVDGVNALWGR--STIKKEDK--SFVDPEELTLVYNLRKLMRND--WAG-GAIITTLSQTGSLYTS----RAE----------------------YLPQELL---------GE-------MGFDNMDPF--VP---------------VSVPNY-------SEKEFESCYLYYTD-----------RHWLQHPQSLTEDG-KKELIFL-SN--RNPSVFERLCAFL-------------------------MAARTRLPLLFSRTLPLYKDLKCAHTEVPV---------KPPAY--PPI--VPSLTAKSKSARQRQAEEQ---------V-------KKICASP-VEEKLSLITRVQ---------------------WMKFVVYPQTFARNADKWYQHFTKTAY--IPGLPEKFTLGSEDLMGMDDE-------AFADIRSLVT-----NVILQERWHMKKRKPF--------LFRVQEQTFGPL--LGNLVSGLTHSLA-KYNPQLLLCSLDFNPQVHFYWRR-GQRVI--------PKGHRKGRQE-------------PTRFQIDDCPHSQIRITQQLKQF------TALEDSCAAE----------VPEVP---------YAPNLMPL------------FRRQY---DNHIFTGSKL---P----DPACYGHTQFHLVPD------RYH-----RDRMANLQQSDQVEVFLRANGIASLFAWTGAQAMYQGFWDREDVTRPFVSQAVITDGKYFSFFCYQLNTV-ALSVQTD-INNPR--RNLMWGTESLKLY---------------DRV-EDGKV---L--GLNDGVIKLLVQFLLNQP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LNPELVAAASAAASTLPNSSQV-----------------------------------------------------------------------ESELLRKLRQHESITESQRKGDI--------------KKLGGLIADMKVGKKPNRQ------------------------NSWAANQIRFDDDGRGYTQERSITSELEGIRRR---KNLLSAKRLNIFSPST-NEEAEPTAAHPSLWDIEFANQLSMSIN-----HQPRNGLEEMIQWTKEGKLWQYPINNEDGLEEEASVS----------FYEHVF-LEKHLEEG-F---------------PRQGPVRH-FMELVVAGLSKNPYLTVQQKKDHIFW-FRDYFSAK-EEVLKEADVYLN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSGLSSYAVRMARL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAQIFGEVVNP---------------------ADSRSLKVVQLFQELPLAKRKER----------------RTRRLQG-----------------------------GDLRLRKLRGK-GKPK----------KGEGKRATKKK------------------MVKKKRLRLIAEMARKIRAYRELKSRPRESQKYALDYETMKRPLTGKRLPVLAWQDVRRESRLFSLLAGMRMFGTGRLFTRKSWLE-----------EH--TEPSYWHITKVKV-DYTAE---------------------------------------------------------------------------NMDHGKAWGILTYKG-KTQSEVKEVDQVMYHDWRLIPKHMEQQFRDFQPL-PEP----PVRYVPYPPLLRAMILAQHKKTYGAAMA------------------------------------------------KEPLLPLQRDVLLNKDYFQKQERERQRAEGTPV---------------------MASHTSKSIRSLGRVNMSVLGLHK----------------------------------------AVNRARYITGLSANASS---------------------------------------------------------------------NNKGHPERNERGLVARKPKREEGDP------------------------------------------------RTEKM--------------------------------------------------------------AADQDWTAV---------------------------------------------------------YPSAA----------------SFRPNAV---------------------PLP---VRMG---------------------YPVKGGVPPGK--------------------KGNLELIKV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLSSL-NLDDHARKKMIKLVG--------------------ER--------YSKDTDVLTIKADRCPLRQQNLDHAMYLLTVLYHESWKTEAWEAEKTVADM-EEYC--------WEDSPSQRNVLDLLARMKAAGEEEG-----------EEVREQLLGRREVQEYRNSVTRLKN------------------------E------GENEDTMTQYKEAVKKVLSL----------------------------MGSKVSSKMAAPTARVLQV-----------------------------VRPHA-----PLIR-------------------------FPNRQDLAK---PNAQQALKSLAISF---------SPNNTVDLPSASAPPP---FSKPHSPLTPLPGTPDTLASV-----------QLLTSRYRRRPLAADEMEYIQR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------G---------------------------------G-PE--------------------------- Trichoplax_adhaerens ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MISVHILIYFFSSIS-IVIGINP------------------------------------------------------------------LAHKDFF--DVRQL-----------------------------------------------------------------------------------YSIKSLFDAGVHLGHKTGVWNPLMKQYIYGDRHGNHIIDLNETDRHLFLALNVTSHIAYRKGVILFVCCRPQFQHLVQKTARECQEFFVIQRWRGGILTNAH------------KLLPV------------------------PRLPDLIIFLS-VPY---N----MDAIRESAQANIPSIGIVDTDCNPNLITYPIAGNDDSLSSLELYCRLFSTAILNAK----------------VQRQ---------------------------------------NDDNYTIDKSNDGETPRDNSRAEMAS-----------------------------------------------------------------------------------------------------------------------------------------------------RP--YRYG----------VTVASESQNTGCISGSRQWTRERITDDLMIRSFIRGTFLPFL-DHKRQ--TVVIKRKLNTII-----VAL-------------------------FV--VPR------DQISRIY------------------------------------------------------------------------------------------------------------------------------------------------FLVGYAEKLMG------------------------AMFGCNVQLVL----------------QTGHY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLTGLRFTSICYKVSAIVSNVRGSIAKCENIYRVASLNCLYTPLDQRNYTTALTRHEF--------------------------------NILRKAATGGRGRRGTRV-KKKAVDF------------------------------------NAAVDKFKWPGYNAPL------------ESTKLGKRTSLSSTEEH--------QEDQPSFSPRVDNYRSTL----KKDLGRGWTGFGWGG----RSLGSPAAPD---GTILDE-----FYSTCIELRRVTNQTSG-GKRSRMRALVIVGNKNGAIGYAFGKGQ-DV-RTALRKAKNRAVNYLCHVDRCDGHTIFHDIKTKYKKTHVKMEKRSKG----------------------------------------------------------------------EGLRCHRAITSICELAGIADLRAK---VIGST-NPGNIIHAAFKA-L--------------------------------QCQETFQQLSDR-----------------TNLKVVEFRPENGY-RPVVVASP-------------------------------------------------------------------------------------------SSGVALKSKKSRIIAPHHLEMDNI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPRYEMPIIIR-CMKQPEQ---YIEMLKRTASRIFNQGGVIRKV-E---NLGTDRLLPY----RIRAHTVWY-DRGSYFLFDFHGAPPIVKRLH-----SELKLDEDVIRHSIV-SNDDPVTIS--------FRKEKKICRS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FIHNSMNMNYAGQQPMMVGQANPWTITAEQLNNYQRMFTGLNPTNGYLSGESARNYFMRSNLPSNVLAQIW--------------------MAHIDARVTALVNFPISIYPWSNSSLILQKSSNLLASNQQDP----------LQ----QSAAAADL------------------------------------------------------SEQLA---QLDDSVDNQIAQTESDSN-----AENPESQLA---------------------TRKPKAADSQTG-------------PTAVNDPVAHKFVNCMMYDGKKSLSR--RIFNEALEMVKKS----------------------------------------------------------------------------QIEK--------YGSNPDDSNIVM------------NPMKIF------HGAIDNAKPIIGVQTIK--RGGKSYQV-PIPLKERRRYFLAIKWFITIARSG-----KENGMSKKLAKEFLNAYNNEG-----------------------------AVVKKKI------------------------------ELHK---IAESNRAYAHYRWW-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTSLMHMVGRRKFSTGLPSIFKLHRM-D-----AYRGIQVWKSL-----------VQTNTNRLITRQYSRLDTNRNEQQSSSIIPEER----YKNEIAAFE----RGK-----RRLALM--------MEKDPETF------------------------------------------TDQDIEEALAYLLPSSLFAKDARPIMKHP------L---------------------------------ELLPKIQEKK------------------------------------------------------------IDK----------------------------DGRPFAAGY------------------------------------------------------------------------------------YTGFPAFYNTIHVIFFI------------------------RFKAIKYCLQVQFGNE---------------------IGEREELLMSLSLGKE---VD--------RLADEVTQDLAPADFSQDN--TNLSFRWLSSDQMKD-ILQEDITDRQYDY---LIARLERLQQFPNSNRV-KDFMDKYRKN----VELRSTKVKIRPLSV-----AGVSYNK---GKRKTAV---ANIQ-IQEGTG---NVTINDKSLVEYFQQLLHREQVLYPLLVLNLTHAFDITCS-----------------VRGGGLS---GQAGAIRLGIARALLSFNEA-YKETLDECKFGDKFWIILDTDELLHRDPRIVERKKPGQKKARRKFAWVKR-----------------------------------------------------------------------------MATMWRSFRNQIAVYRILADNIWS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNKLVAVNQHRFMGNTTSLQPKQAKKAIDDGN---Q--------------------------------------------VLY------------GEISIKILGNDFAVLDSYAKFLRMAANNLKIKISGRVDLPA-KIQKFTVLKSPHIFKKHRTQYEVRTHSRILKVRNLTAKTADIYLEYIQRNIPEGVAMTVFEVICA-------------------------------------------------------------------------------------SQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHELEKKNIVAG------------------VAHIS--ATFNNTIVTITDTQG-AVVAWSSAGSNGFKGSRKSTPYAAQVTAENVAKK-VTEFGMK----TISV--KIQGPGTGRDSAVRGLISSG-----LNVTTIKDITPIPHN-GCRPPKRRRV---------------------------------------------------------------------------------------------------MRKKPKK------------------------------------PKRTLGQ----------PHMKGVVLSTFTRKPKKPNSAQRKCVAVRVK---NGKRVIAYVPYGGHSLQEHSVVLIQGGRVQDLPGVRYTCVRGVYDLTWNK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRRDKKRRALFDKFEGERLRWKTIAKSAILPKEIT-----------NYAKEVLHNKFPRDSSITRIRNRCNLTGRP--RGLVRQYGISRIKFRELADSGKLAGVT-R-----SSW---------------------------------------------------------------------------MLDPGDQAIQGCRWIGKTITSLIALSLKPLDRGR-----------------------------EPLNHRAESQLTSILMAASV--------------------------------------------------CKLLSRLTLSSNAKTLLTSNLSKTASCITTVPSLANPIPSINLLKNVSILQKTNLATLA-TDKHARKDEICYRFNKVEELKRQSELNRLAIHEAIKKYQMH--------------------------PNDYGSSPVQVAILTTRIHR---LRYHMTLN----KKDKHNRRRLLMMIDKRKKHLNYLKRKDFTI--YCKLLEELLIRPTIKHKYGKINP--IKRKRRF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVVAIRLALHGCR--HRPFYHIVVA----NKR---SKRN-GLPLEQVGSFDPLPN-------RSNE---KLVALNIERIK--------YWLG-VGAQPTKPVTALLAMAGILPIHP----------------------------------RIEYEATRRLKMKESNKN----------------------------------------------------TEASEDTTA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPPVRHHTAIFSAGPTRARRLKPEELRPIKNKV------------------------------------------------------------------------------------------------------------------------------------DEDG-------------------------NPLPCAL---C-----KIKIDY---KNVRLLSQFISND--TGMIYGRRITGLCGHKQK----ELTKAIRRARTMGFMPYTYKYPEYLND-------PKPF-----------------------------------------------------------------------------------------------------------------------------------------------------MPAHAGFLARTVFVRNN-------------------------A--------IEAGYKSLQRILNREW-----------------------------IPQKVER--------------------------------------------------------KRYYEK-------------PTV--------------------------KRRRLEHE--------------------------KCNRILLRESKKRVD--FIMARHRP-SP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WI------------------------------------------------------------------------------PRFNDPTVQQILSK-ITGVDL-VKIFHSR---------------PQEQPKLP-----------TYKLMSDVEFKAAE-AKAIQEAKQLLAMPPQMVQ---RERGISRVITIDKEFVGYDED--NANY--IFTDISLSATDRDRRVVVREPN-GALRYATWDERDKMNQIYYPKLGRQLKVPLMFQ-GKNLENSF--SQLRHADLLDLAVLQFEPDSSMYIQVHQKTYEN-LDD-----------------HKNYDLLRSTRHFGGMAYHLVKRNRFHG-LLSDMLT-RKLISDACDLIGLYCLLH---------------------------------------------------------PQSSLARQIKE---------------------------------------------------------------------------------------------MASRNFKVGTVYTRVLGLLKSGA---I--KQKPLWFDIVETFPP------ILPTMHNRAPVPG-------------------------------------RARKLQYWEDEVREKFYKEFKFI---------------EPVNLYETDNKP--TICDRFIMHYEQF---SQ-EETDGDVAFAKSKE---ALEQEGVTFSRIKEKE-----------------EKEAVPVKENTASEDNASIENIFQL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRGKSKIFLRSLD-YLS----KWKL--PL-----KNSVNSITI--SYN----THGGISKGLREFVK---------------------------------YKLPQLQYNNPKVQ--MLKFKNRAPVPNITLFHDDGRKWTIDAEKTSMQEL--VMQLESVAKKDSKTL-LLEEQARASQHNR-ANFGD-ARQGHFCMCEIPGQVS--------------------CP-----------AKRL---LSEKFRKKP-------WMQKGQ-----------------MAAGRVMMFQRARIACQMIV----------------TRQHY----------RGMAAIPETLRMETKEKKEYERKLMC---WRKEMA-VLRKKFFDHHQRYMQTQLSSQEDTKEEEKRQDVVTERIIQERNKKISKRREIREKQI------------------------------------------------RQKAAVSREVGAAKQQASEEKILNKYTQAVSNQMVESENFITEDNIDAKLREIITNTKDYNFYVYEDGKIV----------TPSDS----------------TEVE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKD------------SNFENMLRHSKFIGI--GKPGKKKVTGHIKHVVGD----DLYVDFGGKFYGVVKRPSY----AGDRGYKLGDSVTIRLRDTEVTGHFIGQSRHMTLCEADISLT-------------------------------------------------------------------------------MACSDEIWNFARTLSTSIAANN-----------------------------------ATVTMQQPSDGDEHQASVE-----------------------------RESNATSLSIHVLH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D--------------------------IEHIGQFYTV---------RQDDMDAVLAKA-LPR------------------------------------------RLTSFSKVIGSADIMIRDPAIDIINQL---KKRSPD----------------EQPLKFIIGGRDGTGKTVTLAHVIHYCY-RSNWFILHVPSVYKWISPNCE--VKR-SHRRKKF---------WDQIDHACEW---------LKLCKSINKHL-IG--NMFIKETFHYGRGD-KFVKGDS---LAKVIEQGLLKSEF--------SV------DVVECILQELATQN------------------EIPVLYAVDEYNAFFGK--SAVQDWDK--------------------KNR----N-GAYVMAISRTGAPR------THC----------------------YTAKQLL---------PG-------VGMKRSEPY--SP---------------KVVSNL-------TKEEVKTFIHYYKM-----------KSWLNCR------------KTL-----CIDFHISK------------------------------------------------------------------------------------------------------------------------------------------------------------------MVPPRTQAIQCDSKYLWLTKSVL--QEGMP-------EVYDESVTEA------TLKRLSSYLH-----KSILQAKLFQIESNHR----------SKAEPFAQGL--LQDIMRIFWSINPLDEHPYMSKASLAYRPTIAAYWTR--DFEM----------------------------------FQIEDRPTYVLRCKFPLGKF------AEPKIEQLRPAKY-------LPVGD--------------LGL------------FKRH----VHLDSFPGYK---I---GNPLPYIHTQII------------------IDRKSYKSEQ------TIARGIISSFAQLAAHAQNKDGKLGQSLKHPLCCQTIITNGQQFTFMCYQLNTL-----KTNNIEKGL--VNMAWASDTMDLF---------------SSY--NGEI------DINEKCLKYIAQFFVNKPIPFKVI-----------------------------------K---------------KKSVKASEEVVQ--------------------------------------------------------------------------------------------------------------------MLRLLSINSLSIPCYRMVTGAIATRYRPYSNDLDLIQLLQNQQAAEKDASQQKNDEDQSNNISDLLASMKVDRTTSSYDITPEFLAQTAALAKLEKELQSPAPSE-----------------------------------------------EKLVGQEEKLVEQEKKLVEQEKKLVGQEEKFLGQKE-------KLVGEEQAGKQEEVKQKTEQIQSQPVRNVINRKEEILKAFQDVANWIPN----------YNNEIQDVSQYNHLLHE---IFHTDKLTSKETDTPPKVKSAGNVASNKSTISLGSGDGPRLTAEVMSCHICSNYTYEHSILAYLKQHPLMFSPTTQPKLNLRQNIYLHLSMLITNPFENCVAKLDPSMDILNYWIIVTKSGSFRSITKMPKGSVRH-FASLIITGLQQNPHLSVAEKVKHINW-YKKFFLKK-QDELQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSGHVRNISRL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAKIFGRLPFK---------------------TDPKSYKVVKAFRQQP--KGPQIV-EYTQPIQR-FNSLLLRLRHMGLYTDEHLD------------------FIDENEQKRRLKGK-VPPK----------KGQGRRSAKKK---------------------MLEPPVMRKLN------LLLKGRSL--------------------------------ANLPNVLNRLKYYGIGKKVTRAIWL------------KY--DEPSYWTITRVSF-KR------------------------------------------------------------------------------DMYHANAWGIFTFRG-KTEEQARKIRSCRKRQW-LVLEGDDQVSNPFVGL-IQRR---SSKLILYKQL--HLSIKSTNQSIIFIPK------------------------------------------------LSLHLQINED----------------------------------------------MAAYSLQTRNAMTSPS------------------------------------------------------------------------------------------------------------------------------------RKPRIDRKTMQRIDRNRQKLETLRA-------------------------------------------------------------------------------------------------------------------AYEDDLSQI---------------------------------------------------------LTTSN----------------VYNAALF---------------------DLP---IRMG--------------------RPIKPEVLPPRA--------------------AGNIELLKI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNFFHLTPQKVRRDTDALKA---LCNAWPSKIKRR---------PI-RIYSRNYLYAGP-SVAHPKSHFVKLEVNINDL-PLNESARKRLMALAG--------------------NY--------YDAETNLLTLVGNKCPTRKQNREYVMYLLTALILESKKC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ; END; BEGIN SETS; CHARSET S13 (CHARACTERS = S_Blocks) = 7191-7383; CHARSET S35 (CHARACTERS = S_Blocks) = 16493-17476; CHARSET S34 (CHARACTERS = S_Blocks) = 16118-16492; CHARSET S15 (CHARACTERS = S_Blocks) = 7698-8181; CHARSET S33 (CHARACTERS = S_Blocks) = 15114-16117; CHARSET S05 (CHARACTERS = S_Blocks) = 2312-3631; CHARSET S21 (CHARACTERS = S_Blocks) = 9651-10478; CHARSET S26 (CHARACTERS = S_Blocks) = 11723-12056; CHARSET S19 (CHARACTERS = S_Blocks) = 9554-9650; CHARSET S09 (CHARACTERS = S_Blocks) = 4856-5746; CHARSET S23 (CHARACTERS = S_Blocks) = 10998-11294; CHARSET S14 (CHARACTERS = S_Blocks) = 7384-7697; CHARSET S30 (CHARACTERS = S_Blocks) = 13809-14575; CHARSET S10 (CHARACTERS = S_Blocks) = 5747-6466; CHARSET S11 (CHARACTERS = S_Blocks) = 6467-6928; CHARSET S03_S24 (CHARACTERS = S_Blocks) = 1307-1761; CHARSET S07 (CHARACTERS = S_Blocks) = 4106-4668; CHARSET S22 (CHARACTERS = S_Blocks) = 10479-10997; CHARSET S16 (CHARACTERS = S_Blocks) = 8182-8603; CHARSET S04 (CHARACTERS = S_Blocks) = 1762-2311; CHARSET S27 (CHARACTERS = S_Blocks) = 12057-12603; CHARSET S06 (CHARACTERS = S_Blocks) = 3632-4105; CHARSET S31 (CHARACTERS = S_Blocks) = 14576-15113; CHARSET S18 (CHARACTERS = S_Blocks) = 9172-9553; CHARSET S08 (CHARACTERS = S_Blocks) = 4669-4855; CHARSET S29 (CHARACTERS = S_Blocks) = 12889-13808; CHARSET S17 (CHARACTERS = S_Blocks) = 8604-9171; CHARSET S36 (CHARACTERS = S_Blocks) = 17477-17924; CHARSET S02 (CHARACTERS = S_Blocks) = 1-1306; CHARSET S25 (CHARACTERS = S_Blocks) = 11295-11722; CHARSET S28 (CHARACTERS = S_Blocks) = 12604-12888; CHARSET S12 (CHARACTERS = S_Blocks) = 6929-7190; END;