#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 18, 2025; 21:25 GMT TreeBASE (cc) 1994-2008 Study reference: Vogeler S., Galloway T.S., Lyons B.P., & Bean T.P. 2014. The nuclear receptor gene family in the Pacific oyster, Crassostrea gigas, contains a novel subfamily group. BMC Genomics, 15: 369. TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S15636] BEGIN TAXA; TITLE 'Species_list_nuclear_receptors'; DIMENSIONS NTAX=131; TAXLABELS Aplysia_californica_ER Biomphalaria_glabrata_RXR Caenorhabditis_elegans_DAF12 Caenorhabditis_elegans_FAX1 Caenorhabditis_elegans_NHR23 Caenorhabditis_elegans_NHR25 Caenorhabditis_elegans_NHR41 Caenorhabditis_elegans_NHR6 Caenorhabditis_elegans_NHR64 Caenorhabditis_elegans_NHR69 Caenorhabditis_elegans_NHR8 Caenorhabditis_elegans_NHR85 Caenorhabditis_elegans_NHR91 Caenorhabditis_elegans_SEX1 Caenorhabditis_elegans_UNC55 Crassostrea_gigas_ER Crassostrea_gigas_NHR42 Crassostrea_gigas_NHR43 Crassostrea_gigas_NR1A Crassostrea_gigas_NR1B Crassostrea_gigas_NR1C Crassostrea_gigas_NR1CDEFa Crassostrea_gigas_NR1CDEFb Crassostrea_gigas_NR1D Crassostrea_gigas_NR1E Crassostrea_gigas_NR1F Crassostrea_gigas_NR1H Crassostrea_gigas_NR1Ja Crassostrea_gigas_NR1Jb Crassostrea_gigas_NR1Jg Crassostrea_gigas_NR1P1 Crassostrea_gigas_NR1P10 Crassostrea_gigas_NR1P11 Crassostrea_gigas_NR1P2 Crassostrea_gigas_NR1P3 Crassostrea_gigas_NR1P4 Crassostrea_gigas_NR1P5 Crassostrea_gigas_NR1P6 Crassostrea_gigas_NR1P7 Crassostrea_gigas_NR1P8 Crassostrea_gigas_NR1P9 Crassostrea_gigas_NR2A Crassostrea_gigas_NR2B Crassostrea_gigas_NR2CD Crassostrea_gigas_NR2E1 Crassostrea_gigas_NR2E2 Crassostrea_gigas_NR2E3 Crassostrea_gigas_NR2E5 Crassostrea_gigas_NR2F Crassostrea_gigas_NR3A Crassostrea_gigas_NR3B Crassostrea_gigas_NR4A Crassostrea_gigas_NR5A Crassostrea_gigas_NR5B Drosophila_melanogaster_DERR Drosophila_melanogaster_DHR3 Drosophila_melanogaster_DHR38 Drosophila_melanogaster_DHR39 Drosophila_melanogaster_DHR4 Drosophila_melanogaster_DHR51 Drosophila_melanogaster_DHR78 Drosophila_melanogaster_DHR83 Drosophila_melanogaster_DHR96 Drosophila_melanogaster_DSF Drosophila_melanogaster_E75 Drosophila_melanogaster_E78 Drosophila_melanogaster_EcR Drosophila_melanogaster_FTZF1 Drosophila_melanogaster_HNF4 Drosophila_melanogaster_SVP Drosophila_melanogaster_TLL Drosophila_melanogaster_USP Homo_sapiens_AR Homo_sapiens_CAR Homo_sapiens_COUPTF1 Homo_sapiens_COUPTF2 Homo_sapiens_EAR2 Homo_sapiens_ERRa Homo_sapiens_ERRb Homo_sapiens_ERRg Homo_sapiens_ERa Homo_sapiens_ERb Homo_sapiens_FXR Homo_sapiens_GCNF Homo_sapiens_GR Homo_sapiens_HNF4a Homo_sapiens_HNF4b Homo_sapiens_LRH Homo_sapiens_LXRa Homo_sapiens_LXRb Homo_sapiens_MR Homo_sapiens_NGFIB Homo_sapiens_NOR1 Homo_sapiens_NURR1 Homo_sapiens_PNR Homo_sapiens_PPARa Homo_sapiens_PPARb Homo_sapiens_PPARg Homo_sapiens_PR Homo_sapiens_PXR Homo_sapiens_RARa Homo_sapiens_RARb Homo_sapiens_RARg Homo_sapiens_RORa Homo_sapiens_RORb Homo_sapiens_RORg Homo_sapiens_RXRa Homo_sapiens_RXRb Homo_sapiens_RXRg Homo_sapiens_Reverba Homo_sapiens_Reverbb Homo_sapiens_SF1 Homo_sapiens_THRa Homo_sapiens_THRb Homo_sapiens_TLX Homo_sapiens_TR2 Homo_sapiens_TR4 Homo_sapiens_VDR Lymnaea_stagnalis_RAR Lymnaea_stagnalis_RXR Marisa_cornuarietis_ER Marisa_cornuarietis_ERR Mytilus_edulis_ER Mytilus_galloprovincialis_NR1DEF Mytilus_galloprovincialis_NR1Dv1 Mytilus_galloprovincialis_NR1G Nucella_lapillus_ER Nucella_lapillus_RXR Octopus_vulgaris_ER Thais_clavigera_ER Thais_clavigera_RXR ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M21617] TITLE Crassostrea_gigas_nuclear_receptor_aa_sequences_matrix; LINK TAXA = 'Species_list_nuclear_receptors'; DIMENSIONS NCHAR=221; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 ] [ . . . . . . . . . . . . . . . . . . . . . . ] Aplysia_californica_ER CQVCSDNASGFHYGVWSCEGCKAFFKRSI----QGPV--DYI-CPA-TN----TCTIDKHRRKS---CQACRLRRCYEVGMNKGLNTLIKLADRELVYLINWAKHVPGYTCLTLGDQVHLIECCWMELLLLNCAFRSMEHEVLEQVS---AVSEQMLL-HGLNKEELLLLQATVLVNPLDSFLKIQEMRQLILDVFMEVAGRHQRHAPSILLLLTHIRQAG Biomphalaria_glabrata_RXR CAICGDRASGKHYGVYSCEGCKGFFKRTV----RKDL--TYA-CRD-DK----NCMIDKRQRNR---CQYCRYMKCLSMGMKREVTNICQAADKQLFTLVEWAKRIPHFTELPLEDQVILLRAGWNELLIAGFSHRSIMAKIFDRVL--TELVAKMRD-MKMDKTELGCLRAVVLFNGLTAVQEVEQLREKVYASLEEYTKSRYGRFAKLLLRLPALRSIG Caenorhabditis_elegans_DAF12 CRVCGDHATGYNFNVITCESCKAFFRRNA----LRPK--EFK-CPY-SE----DCEINSVSRRF---CQKCRLRKCFTVGMKKEPADIMNIMDVTMRRFVKVAKGVPAFREVSQEGKFSLLKGGMIEMLTVRGVTRYDASTQKAKCL---EFFGFFDEEIKKNELAVYLVMLAVLFSNENDVRIVTERHNHFMSLLNRYLESLFRIFERIPKALGLLNEIA Caenorhabditis_elegans_FAX1 CAVCGDVSSGKHYGILACNGCSGFFKRSV----RRRL--IYR-CQA-GT---GNCVVDKAHRNQ---CQACRLKKCLNKGMNKDKDSLQETTMSQLESVLQWAQQFRLFTVLTNSEKRQIILTQWPRLLCISLCEQAEDVSFDDHLT---SLMLKFRR-LDVSPAEFNCLKAITIFM--RELSLWRAGWDNRASIITVYPAGERARLVAAALLLAEHSVMG Caenorhabditis_elegans_NHR23 CKVCGDKSSGVHYGVITCEGCKGFFRRSQ----SSIV--NYQ-CPR-QK----NCVVDRVNRNR---CQYCRLKKCIELGMSRDWELFARELNPLIQAIIEFAKSIDGFMNLPQETQIQLLKGSVFELSLVFAAMYYNVDALIVEVN---NTLQEIVH-LQPHQSELALLAAGLILEGILDTATIAT-AETLKNALYQSVMPRIDTIHRIQDVETRIRQTA Caenorhabditis_elegans_NHR25 CPVCGDRVSGYHYGLLTCESCKGFFKRTV----QNKK--QYQ-CSA-EA----NCHVDRTCRKR---CPSCRFQKCLTMGMKMEHAFSIQVAEENLKDIVIWAKNDQLFSKLSLDDQMILLQTSWTTVHIVDITNAMVHGNFVSSWN---DVVIRLRN-MGFTNFDYCAFRFLALF-MDSFPAVSTARSRVLQSWREVRCTTAFLEIFEQIRRL------- Caenorhabditis_elegans_NHR41 CVVCGDKASGRHYGAVSCEGCKGFFKRSI----RKRI--GYV-CRS-QK----DCPVTKFHRNR---CQYCRLRKCLSMGMRSEHQYISEITTRLLFLTVHFVKDSR--VSLRTSTMEGLLKSKWCDLYILALMQTADKIKQMQRLL---QLSQLFAS-RELTAVEYAYLKMISFTASSMASPETRSVNQMASQELFEYVSSSKERFSRILQLLPCLRWFD Caenorhabditis_elegans_NHR6 CAVCNDRAVCLHYGARTCEGCKGFFKRTV----QKNS--KYT-CAG-NK----TCPIDKRYRSR---CQYCRYQKCLEVGMVKEETIALRILHGELHATKKLLMAMPQISEIQPADFQILLSRSFFAIMAIRVANRCGNSTIIRFMV---DKARTFSSLVDWEPQAFAAFIALQFLAGLTNKPLVDQVQSTIINALKDHCSGSQNKLAKIVRLTQEFDVFH Caenorhabditis_elegans_NHR64 CAICGDRATGKHYGAMSCDGCKGFFRRTI----RKRH--SYV-CRF-GE----KCQVDKAKRNS---CRKCRFDVCLRKGMRRDTNDVTDSMNQQLTLMVEWAKVLEGFQRVDNITQVALLRHFSAQHLVMCAAFRSIHLSVAERII--DQVTNPMRS-LHMNEIEYIALKAIAFFDGIESYSDVEEMRQRILESFERHVRYVSLRFANLLLLLPPMLAIS Caenorhabditis_elegans_NHR69 CHICNDKSTGKHYGAISCDGCKGFFRRSI----RKRY--HYQ-CRF-EQ----NCDVTKNKRNA---CRACRLQKCVKAGMKSNLDDIGKSIHQQLVLFIEWAKSLPQFSFLAQADQAALLKGGAASIIVLGVAYRSICLTVVGRII--DEIVNPMRR-LNMDLIEYVALKAILFFNEINDQSPVENARYAFLRSLQRRCTDKACRSGKLLLLLPSLQAIA Caenorhabditis_elegans_NHR8 CTVCSDRANGYNFGVLTCESCKAFFRRNA----SKHK--EIK-CPF-SD----SCQITSASRKF---CQACRLNKCFAVGMNSEIDGVFRIIEEALRRIVNMACQLSLFRELHVDDRKNLLKSGFGELLIVRGLMAYDKSDHYKAHM---NLLSTFGEDVRNNEHLMLIFNAAVIFHNLRDSKRVHSTQAKYFQMLLKLLTFEYIAYSNLLNQVVELHRVN Caenorhabditis_elegans_NHR85 CQVCSDKASGFHYGVFACEGCKGFFRRSI----QQKI--TYRACTR-AE----DCLILRNNRNR---CQCCRLKKCLAVGMSRDCPITSNFIVIPLKAAIDFANSIPAFLSITQTQRVHLLQNSVFDVMLLASASASTSQHIPQAIQ---SISARIRQ---LPPQTVPILTAIAVCQLLPESQQPMLLAERLWCVLGKLGGIQSATAPSLLADVRTLRQWH Caenorhabditis_elegans_NHR91 CSVCGDKSTGLHYGAATCEGCKGFFKRSV----QNKK--VYH-CSQ-DN----CCEIDKQNRNR---CQSCRFRKCISKGMLTECKRLTRIGDEIVEQLVEWTKTLPFFDELPVEAHTHLLTQRWAELVLLSAGYYMIDETLVTRFT---TLLHSFSN-LKVSPEAYVCIKAITLLH-----DKVNTLQDHFVKTLQIHLHQPGTSLAQILDWLPDLRNAS Caenorhabditis_elegans_SEX1 CKVCGDKASGYHYGVTSCEGCKGFFRRSI----QRKI--DYR-CLK-QQ----VCEIKRESRNR---CQYCRFKKCLDSGMSKDWQIYAHEIDVDIKEVVNFVKEIPKFNFINGNDKAVLLRKNAFPLYLLRIVRGMSNRGLADEML---AFANHIIT-IGCTDGDIALFIVLILCQNFKSQLQLLEMFDFYKKVLFQKMTCRIDTYKQLMKCIHELNRLN Caenorhabditis_elegans_UNC55 CVVCGDKSSGKHYGQFSCEGCKSFFKRSI----RRSL--SYT-CRA-TK----NCAIDVQHRNQ---CQYCRLTKCIRMGMRKEKESIFEFAAQTIFATVNWART--SMSNLVKGDQLILLRHSWTPIFIFALAQSNFALNQFQGFQ---AKIDKIRD-FHLDVVESSSLRAVLLFSALEEKGKIEEIVEKLKSAVDEYCKMNKERYHQICECLQLLKST- Crassostrea_gigas_ER CQVCSDNASGFHYGVWSCEGCKAFFKRSI----QGPV--DYV-CPA-TN----TCTIDKHRRKS---CQACRLRKCYEVGMNKGLNSLVKLAERELVHLINWAKNVPGYTDLSLSDQVHLIECCWMELLLLNCAFRSIEHGIFEQVA---AVSEQMMQ-NHLHKDELLLLQAMVLVNRLASYNQIFNMQQSLLDAIVDTAQKYHRHVPAVLLLLTHIRQAG Crassostrea_gigas_NHR42 CMICNDRGSGYHYSVFSCEGCKGFFKRSV----QKNL--VYT-CKN-EG----SCVINKFTRNN---CQYCRFVKCTQMGMKREINQLMQYGYAELKYIIDWAKKVPGFTELRLEDQMALLKSSFMELNVLRLSYRSMETGLVAATV---EFSARLKE-LSIDKVEFCILNGIVLTYNLMDKQKVILLQTQILDRLRKYHSHKFRRYGKMLLRLPFLRTVS Crassostrea_gigas_NHR43 CHVCQDQATGVHYGVATCEGCKGFFKRST----IRGE--KYK-CFF-GG----QCEITPQNRNR---CKSCRFRLCLESGMSLEWPNLMQSVQFYNDVILGFAFGCPGFKNLQSELKEILTQNAYFEIWIL-LMADFCIDGSVVEIK---GVLEKINK-CQLCDLEIGLLCAILLIDTVVTKIHTTQSTKKLSDIFSLTPLIKKSTLLRLQVTQYGVEQVP Crassostrea_gigas_NR1A CVVCGDAATGYHYRCMTCEGCKGFFRRTI----QKNL--QYH-CKW-NK----MCSIDKNSRNQ---CQECRFRKCLNVGMATDWQQLAEAMTPSIVKVVEFAKNVPGFIQLFVDDQILLLKSCCMEIMCLRAACRYDPEKLVEPIF---EFAVGLSK-LKLDKTELALLAAVLLMQGLKEPEAVEKLQDSILGAFKRYIATKRVHWAKILMKVTDLRTIS Crassostrea_gigas_NR1B CVVCSDKSSGYHYGVSSCEGCKGFFRRSV----QKNM--QYT-CHK-DK----NCPINKVTRNR---CQYCRLQKCYATGMSKEWDKVTELSSKGIIKIVEFAKKMPGFTSLSTSDQITLLKAACLEIMILRLCSRYDLDKLTDTIF---RFASSLKV-LNIDEMEYAVLSAICLISGLEESERVEQMQEPILEALKHYVRTRRNVFAKILYKLTDLRSIS Crassostrea_gigas_NR1C CKICGDKASGFHYGVFSCEGCKGFFRRTV----RQKL--VYKPCEN-PK----GCLIMRISRNR---CQYCRMQRCIMAGMSHERKFCSQYVTDMVRFISIFAREIPQFTQMDIDDQKTLIKHCILESIIIHCVSRSPSDCLIYDVV---TCVKKLKA-LRLTEVELAIFAAMVLFCDLKCSDVLEKMEIELYLALKCQFLLNHNLFPKIVEIICSIRAIT Crassostrea_gigas_NR1CDEFa CKVCGDESSGFHYGVDSCEGCKGFFRRCI----TQGM--THK-CSN-EE----KCEITPFTRNS---CQYCRLKKCFAVGMSREWQQFVSQMVPEITLVVKFCKKIPGFGEIDQEDQINLIKQGSFEVMLCRFCNLVDYKKFMDEFF---NVAEMFNP-LKLTDGEIGLFTSTLIICDYDNVFMKAVSTMRTFKVVNLKHRIALDMFPPLHCEVFEHGDCS Crassostrea_gigas_NR1CDEFb CLVCGDRSSGIHYGVLACEGCKGFFRRAL----QDIGDPARKRCYY-NK----SCDITILTRNR---CQYCRLQKCLALGMSRSWEGFQSLLNKTIQDTVIFAKKIPGFPHLDQDDQISLIKGGCFEVACVIHSKFIDSDTFVELFF---NLCVRFNA-YKLGDAEKALFSALVLISGLKNREKVSKLQELLIQALQTQITQSHGLFPRLLMSISSLRELG Crassostrea_gigas_NR1D CRVCGDKASGFHYGVHACEGCKGFFRRSI----QQKI--QYRPCLK-NQ----QCNIMRVNRNR---CQYCRLKKCIAVGMSRDWSDMSEFFTPAIKSVVDFAKAIPGFCFLSQDDQVTLLKAATFEVLLVRMACLFDPESLLDSMF---DFADRFNK-LNLTDEEVAIFSAIVLLSGLRNVEQLESFQMKLTECLQSMITANHTLFAKLLMKTTDLRTLN Crassostrea_gigas_NR1E CKVCGDRASGFHYGVTSCEGCKGFFRRSI----QKQI--EYR-CLR-DG----KCMVIRLSRNR---CQYCRFKKCLAVGMSRDWHCLASFITPAINSVVEFAKRVTGFPELNQDDQLILIKCGFFEVWLMRMARMFNKAEFVSCMF---DLAQSLNQ-LNLNDTEIGLFCAIVLATGLENPKAVETIQDRLIEALKLQILRNHNLFGTTIVKLPQLRTLG Crassostrea_gigas_NR1F CKVCGDKSSGVHYGIITCEGCKGFFRRSQ----AGPV--NYQ-CPR-NK----NCVIDRVNRNR---CQFCRLQKCLALGMSRDWSEVAEKITIAVQQIIEFAKMLPGFMDLSQDDQIMLLKAGSFELALIRACRVFDERTLREQVF---EFVRNVIQ-LKLTESQLALFSAVVLIRGLKDIADVQKLNEKVLTALKQELGKTHNVLTRLMQLTWTLRQLS Crassostrea_gigas_NR1H CRICGDRASGYHYNALSCEGCKGFFRRSI----TRGA--SYN-CKY-GG----NCEMDMWMRRK---CQSCRLKRCREVGMKEELSSLSKMTVLITHLIVEYAKSLPGFSKLNKEDQIILLKAASSEVMALRASRMYDPASYTELVF---KLCHDMAD-LNSDNAEYALFTAISIFSGLTNRDLVEQIQKVYVDALEEYENKKRCGLAKYLLRLIDLRNIS Crassostrea_gigas_NR1Ja CGVCGDKALGYNFDAITCESCKAFFRRNA----LKTK--VFA-CSF-DG----NCKLDTHTRKF---CSGCRLKKCFDIGMKKEANDLFNLTDIFIRRLIKFAKHVPEFKQLQQEDQIHLLKGGIMEIMVLRSVMGFDAQAMYSDHV---KFVMSLNQLTKANKTILTLLFVIELFSSLKNKELVAKGQEKFSTWLQAYLESIYQLYPKLLMKLLDVRSLG Crassostrea_gigas_NR1Jb CGVCGDRALGYNFDAISCESCKAFFRRNA----PKGL--EYFKCPY-EE----KCKMDVSNRRF---CKRCRLRKCFEIGMRKEMKDLVNIAELSVRRVIDMAKKIKSFKALSQTDQISLLKGGSIELLILRSVISFDKEKLFAEHM---KFTKSLAVDLKADETMLILLLVISLFSNISDKSYVCQEQEKYALLLLRYLESRYAIYPKLLMKLTDIRDLN Crassostrea_gigas_NR1Jg CLVCGDKALGYNFNAVSCESCKAFFRRNA----HKVI--RGR-C---EG----RCDITVESRSF---CKKCRLAKCFTVGMRKDATEFVNLAEGFVRRIIKVAKNIEFFKMICKEDQIALLKGSVVEIMMLRSAINYNVETMFLTYS---KFIKSLMRTIHGDLLALKLLIMLSLFSGVLEHDKIQQIQECYAGILQKYVERRFIMFAKIVMKLTDLRNIN Crassostrea_gigas_NR1P1 CRICGKRASGIHFGVYSCEACKAFFRRCL----QRTS--PYK-CDK-GG----NCIIDEQQKGLN--CSACRLKKCQELGMSKELQDGRRDMVQIVKEYVQFTHGIPNFKTLSPKDQSTLLKASRFEFFAILQYRALDSERVFRGWF---EFARRVKE-CDFSQEEHALVLAISLTFSLEEPDKVEEIQTKLIDSLENLLKETHRRLAKIMDLFVRLRALG Crassostrea_gigas_NR1P10 CRVCGEKASGFHYGVNTCEACKGFFRRSL----RRKT--EYK-CVKSDK----NCTIAPGKRNG---CPLCRYNKCLAVGMSKEVSNFATNMEKSITKFVTFTKTIPGFAALPLEDQANLVKSSRFEFWMFGFWKFIDVENFVEALF---NFGQTLHN-LQMSDLEIALVRCICLTYELKSPEKVEEIQWKMIMCLKYIIEKNHRYLSRIMDRLAAVRNLT Crassostrea_gigas_NR1P11 CRVCGDNASGFHYGANTCEACKGFFRRSIVKIQQNKE--SYK-CIAKGE----GCVLGPGKRNP---CAACRYARCLEVGMSIGMKEMACRMEHGLTMMVDFVRTIPGFADLSVSDQTELIKASHFEFFFLVHHKSFNPDLAVENLF---QFSTSLKN-LDLAFDEIILVRGISVTFQLEDPKAVEQIQWRLINALRVLAKRKNQRLWHILDRLTALRTMT Crassostrea_gigas_NR1P2 CRVCGKKSTGIHFGVYSCEACKTFFRRSF----LRST--PYK-CDK-GG----DCLINAEKQNGSRPCPACRLVKCLDLGMSKDLSEAKYEFMKMANDYIKFCKNIPFFSGLSLEDQKALLKCSHFEFFTILQHKGMNTEKTLLSWA---EFSEEVSK-LQLSPEEFALMLGICVTFPLDYPEDVENIQKRLLETLEFTLSKSHRRLAKLLDLFVRLRVIG Crassostrea_gigas_NR1P3 CRICGKRASGIHFGVYSCEACKAFFRRYL----QRKT--PFK-CNK-GD----KCEIDEQKKGLN--CSACRLKKCLEKGMSKEYDLGREELNKMFDELVQFTHSIVNFSSLPSKDQTALLKAADFDFNMLVDYRCVDADRTLKEWA---EFSRSLQK-LKLTPREHALMLAISLTFPLEAHDEVEKIQNKLIKALEKLVAETNGRFAKLMDVFLRMRGMY Crassostrea_gigas_NR1P4 CKICGKKASGNHYGVNSCEACKGFFRRYL----QRNV--PYK-CNK-GG----KCLENSDNKKNSL-CSACRMQKCLDCGMCREFEVIRDELGILVQEYVRFTHGLPGFSDLPPTDQAKLLKAARLEFFFILGYRSFDSETMAVKWV---NISDDVRN-LSLTTQEHAVILAICLTFDLDARDKVEEIQMLFIDALQYLLKKRLLHFSRIMNVFLKLREMN Crassostrea_gigas_NR1P5 CRICGKLASGIHYGVNSCEACKGFFRRYL----KRKE--PFQ-CTK-GG----NCVIDQSSAGSM--CSGCRLQKCFSLGMSKEFDLIRQELVTVIHEYVRFTHGIPAFQNLPSKDQASLLKAARLEFFLLLGYRSLDPETMSTSWL---EVTRHIRH-LQLHPKEHAAMLGICLTFPLEDPKSVEKIQTCLLGVLQNMLRVRYRHLARIMDVFIKLRGLN Crassostrea_gigas_NR1P6 CKICGKKASGIHYGVNTCEACKGFFRRYL----KRKE--PYV-CDK-GW----NCDLDIRSKGPH--CSACRMKKCLTLGMSKESSRRREEFGLAMADYVAFSNEIPGFNELSARDKATLVKVSRLDFFLSLEYRAKDPETMLRSWW---KLTYDLRG-LQMTTEEHATLLALCLMSKLESPESVQKIEATLVKTMMSLLHRRYLQFSSYISLLTKLRGMS Crassostrea_gigas_NR1P7 CRICGGKASGIHYGVNSCEACKGFFRRYL----LRKE--PYK-CNH-GG----NCAITNRHRGN---CSACRMMKCLDLGMSKELQFNKGTLDNMIKKYVNFSHAIPCFSDLPSQDQAKLLKASRFEFFMLLEYRSLNPDLMMKSWL---EFSRTIRK-LELTNKELAVTLAVALTFRLEQPSFLEQIQDNLVRMLYYLLEDHHVAFSRIISMLTGLRSLT Crassostrea_gigas_NR1P8 CKVCSGNATGIHYGVHTCEPCKAFFRRAI----TDKN--KYA-CLK-EN----SCEITAQKRGN---CSACRLQKCFDLGMSKSIKKIFSHRERSLMKFITFAKCLEGFNTLSMNDKINLVKYGEHEYWVLGHFTHYHPEIASEELL---KMFCTLKD-MDLMYQEVIILRGIVLFSELESAPIVESVQWKLIQCLQYLVEHFHRKFSQCLQLLTDLREVS Crassostrea_gigas_NR1P9 CRICDGEASGIHYGVNTCEACKAFFRRAV----MEKD--KYQ-CAK-DK----NCKIIDRKRGN---CSYCRLQKCLNLGMSRDIKKAIEQIQHGIMKYISFARIIPGFEDLPTDDKMALIKAARFEYWLMGEHVHINTEMAVDRCI---EFAASLQR-LKLTYEEVAVLKAIIITFPLQNPEKVETIQWKLVQCLKYLIAKFHHRFSAYMDKLIFMRELT Crassostrea_gigas_NR2A CAICGDRATGKHYGASSCDGCKGFFRRSV----RKNH--VYS-CRF-NR----NCVVDKDKRNQ---CRYCRLRKCFRAGMKKEANDVCESMKQQLLILVEWAKYIPCFCELTIDDQVALLRAHAGEHLIMGVARRSLGVKVASRIL--DELVQPMKD-VQMDESEFACLKAIVFFDGLTDPQKIKSFRYQVQVNLEDYINDRQGRFGEILLMLPPLQSIT Crassostrea_gigas_NR2B CAICGDRASGKHYGVYSCEGCKGFFKRTV----RKDL--TYA-CRD-DR----NCIIDKRQRNR---CQYCRYMKCLNMGMKREVTNICQAADKQLFTLVEWAKRIPHFTELPLEDQVILLRAGWNELLIAGFSHRSIVVKIFDRVL--TELVAKMRE-MKMDKTELGCLRAIVLFNGVSAVSEVEQLREKVYASLEEYCKMHYGRFAKLLLRLPALRSIG Crassostrea_gigas_NR2CD CVVCGDKASGRHYGCTSCEGCKGFFKRSI----RKQL--GYA-CRG-NK----DCPVNKPHRNR---CQYCRLQKCLAVGMRAEVHYICETASRLLFLSMHWTRSIPAFHVLSQEVQTILVKSSWSELFTLGLAQCAQSMSVIDHILKLQNYIQSLEA-LQIDSEEFAYLKALVLFSSLPNAPQIERVQDRAQRELANHVRQTHDRLAKLLLRLPALHSLS Crassostrea_gigas_NR2E1 CKVCQDHSSGKHYGIYACDGCAGFFKRSI----RRNR--QYI-CKS-RG--QGTCPVDKTHRNQ---CRACRLKKCLEAGMNKDPEAMCEVAARLLFMSVKWAKNVPAFLGLPFRDQVMLLEEGWRELFVLGAAQFQMPVEEIRALQ---EIISKFKS-LQVDPTEFACLKGIVLFKSLQDIHTVAGLQDQAQLTLSKYIQATYFRFGKLLLSIPTLKTVC Crassostrea_gigas_NR2E2 CKVCQDHSSGKHYGIYACDGCAGFFKRSI----RRNR--QYV-CKS-RN--QDKCPVDKTHRNQ---CRACRLNKCVKSGMNRDADSVCETAARILFMTIKWTKSIPAFVGLPNRDQLVLIEESWRDLFILSLAQFRLPIQEIRALH---DVIDKFKL-INVDPTEYTCLKAIVIFKTLRDSHAVALLQDQAQVTLSKYIESTYFRFGKLLLLLPLLQTVS Crassostrea_gigas_NR2E3 CVVCGDTSSGKHYGILACNGCSGFFKRSV----RRKL--IYR-CQA-GT---GMCLVDKAHRNQ---CQACRLKKCLQMGMNKDQETMYECSARLLFVAIRWAKNLPSFANLPFRDQVILLEEAWSELFLLCAIQWSMPMEDNRLLQ---EIFRRFKH-TQVDPAEFACLKAIALFKGLKDPLQVENFQDQAQMMMSQHVRSNYIRFGRLLLMIPSLKFVP Crassostrea_gigas_NR2E5 CLVCGDKASGKHYGVQSCDGCRGFFKRSI----RRSL--EYV-CKE-NG----NCVVDVARRNQ---CQACRFRKCLEMKMNRDNDCTFETAAKLLFMSVKWAKNIPSFLQLPFRDQAILLEESWCELFVLSAAQWSLNIDQLRQLQ---DIIYRLNG-IRLDSTEYACLKALLLFKGLRDSLQVEALQDQAQIMLYDYVSNQKTRFGRLLLQLPALRNVS Crassostrea_gigas_NR2F CVVCGDKSSGKHYGQFTCEGCKSFFKRSV----RRNL--TYT-CRG-SR----QCPIDQHHRNQ---CQYCRLKKCLKMGMRREIENICELAARLLFSAVEWARNIPFFPELQITDQVALLRVSWSELFVLNAAQCSMPLHHIRIFQ---EQVEKLKT-LHVDSAEYSCLKAIVLFSGLSDATHIENIQEKSQCALEEYVRSQYTRFGKLLLRLPSLRTVS Crassostrea_gigas_NR3A CQVCSDNASGFHYGVWSCEGCKAFFKRSI----QGPV--DYV-CPA-TN----TCTIDKHRRKS---CQACRLRKCYEVGMNKGLNSLVKLAERELVHLINWAKNVPGYTDLSLSDQVHLIECCWMELLLLNCAFRSIEHGIFEQVA---AVSEQMMQ-NHLHKDELLLLQAMVLVNRLASYNQIFNMQQSLLDAIVDTAQKYHRHVPAVLLLLTHIRQAG Crassostrea_gigas_NR3B CLVCGDVASGYHYGVSSCEACKAFFKRTI----QGNI--EYS-CPA-NG----DCEITKRRRKA---CQACRFQKCLRVGMLRELATVSDLADRELVITISWAKQVPGFCTLSLSDQMNLLQHSWLEILCLNLVFRSCPYNLDGISR---KLAKKFTD-MEVTKEEYLLLKAMTLCNAIENSEAVRQLQDKLQDSLIEYVKYRYRRLGHLYMLLPALNHMK Crassostrea_gigas_NR4A CAVCGDNAACQHYGVRTCEGCKGFFKRTV----QKNA--KYV-CLA-DK----NCPVDKRRRNR---CQFCRFQKCLSVGMVKETQMFYDLITSSVNIIKAWSTKIPGFSDICQEDQNLLFKSASLELFVLRLSYRMQGNTWINSIA---DFSTSLYR-MSLDISALACMEALTLVTGLKNQAKMEEVQMKIIDSLRDHCVYNSNYFSSILGKVAELRTLS Crassostrea_gigas_NR5A CPVCGDKVSGYHYGLLTCESCKGFFKRTV----QNKK--VYS-CVD-NR----NCHIDKSQRKR---CPYCRFQKCLSVGMKLEINMLCKLSDQLLFLMVEWARTSFFFKDLKVEDQMKLLQNCWSEILILDLVHRLVRETAKESIF---DLVRKMKE-LKIDVNEYLCLKFLILLNGLENRQAVENSQEKVNSALMEYCVNFYDKFGQVLLRLPEVRLIS Crassostrea_gigas_NR5B CPVCGDNVSGYHYGIFTCESCKGFFKRTV----QNNK--TFT-CHR-NG----DCEISRGNRKK---CPSCRFAKCVLMGMKTQIMSMLQLAELKLYKLVRWARNLPQFSSIATDDQILLLQNSWCEILTLNCCFKSMNTPIISRML---SIAEHLRR-LQVDQHEFVALKVLILISGMKEPSRVVEHQDAITEALRQYTESHFTKYGQLLMRLTELAKI- Drosophila_melanogaster_DERR CLVCGDVASGFHYGVASCEACKAFFKRTI----QGNI--EYT-CPA-NN----ECEINKRRRKA---CQACRFQKCLLMGMLKELSVLSDIYDKELVSVIGWAKQIPGFIDLPLNDQMKLLQVSWAEILTLQLTFRSLPFNFYYHCV---QIAQRMER-ISPRREEYYLLKALLLANLLDDQSSLRAFRDTILNSLNDVVYLLRSHQQQLLLLLPSLRQAD Drosophila_melanogaster_DHR3 CKVCGDKSSGVHYGVITCEGCKGFFRRSQ----SSVV--NYQ-CPR-NK----QCVVDRVNRNR---CQYCRLQKCLKLGMSRDWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQLVSRIF---QTAKSIAE-LKLTETELALYQSLVLLWGVRGNTEIQRLFNLSMNAIRQELETNHTVLDTLLNNIPNFRDIS Drosophila_melanogaster_DHR38 CAVCGDTAACQHYGVRTCEGCKGFFKRTV----QKGS--KYV-CLA-DK----NCPVDKRRRNR---CQFCRFQKCLVVGMVKEVQQFYQLLTSSVDVIKQFAEKIPGYFDLLPEDQELLFQSASLELFVLRLAYRARIDDWLNDIM---EFSRSLHN-LEIDISAFACLCALTLITGLREPKKVEQLQMKIIGSLRDHVTYNAHYFSRLLGKLPELRSLS Drosophila_melanogaster_DHR39 CPICGDKISGFHYGIFSCESCKGFFKRTV----QNRK--NYV-CVR-GG----PCQVSISTRKK---CPACRFEKCLQKGMKLEIAHLCNVADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLLFSCCFRSIDTPCIERML---NLTDHLRR-LRVDRYEYVAMKVIVLLQELQEAVKVRECQEKALQSLQAYTLAHYSKFGELLLRIPDLQRT- Drosophila_melanogaster_DHR4 CMICEDKATGLHYGIITCEGCKGFFKRTV----QNRR--VYT-CVA-DG----TCEITKAQRNR---CQYCRFKKCIEQGMVLQSEKLCNIGDSIVHKLVSWTKKLPFYLEIPVEIHTKLLTDKWHEILILTTAAYLQPLHMVDKMT---QITIMFRR-IKLKMEEYVCLKVYILLN-----VELESIQERYVQVLRSYLQNSSARLSELLSHIPEIQAAA Drosophila_melanogaster_DHR51 CVVCGDTSSGKHYGILACNGCSGFFKRSV----RRKL--IYR-CQA-GT---GRCVVDKAHRNQ---CQACRLKKCLQMGMNKDHETVYETSARLLFMAVKWAKNLPSFARLSFRDQVILLEESWSELFLLNAIQWCIPLDDVRTLH---EIFCKYKA-VLVDPAEFACLKAIVLFRGLKDPAQIENLQDQAHVMLSQHTKTQFARFGRLLLMLPLLRMIS Drosophila_melanogaster_DHR78 CLVCGDRASGRHYGAISCEGCKGFFKRSI----RKQL--GYQ-CRG-AM----NCEVTKHHRNR---CQFCRLQKCLASGMRSDIHYVCETGSRIIFLTIHTLRKVPVFEQLEAHTQVKLLRGVWPALMAIALAQCSVPTILTRTLH---DFVQELQS-LDVTDMEFGLLRLILLFNTLLQQRKERSLRGYVRRVQLYALSSLRERFNVLVARLLPLSSLD Drosophila_melanogaster_DHR83 CAVCGDQSSGKHYGVSCCDGCSCFFKRSV----RRGS--SYA-CIA-LV---GNCVVDKARRNW---CPSCRFQRCLAVGMNAAQALHFQILAQILVTCLRQAKANEQFALLDRCQQDAIFQVVWSEIFVLRASHWSLDIS-DEQLK---RLICEAHQ-LRADVLELNFMESLILCR-AINAEYAVILGSHSKAALISLARYTLLRFGQLLLGLRQ----- Drosophila_melanogaster_DHR96 CAVCGDKALGYNFNAVTCESCKAFFRRNA----LAKK--QFT-CPF-NQ----NCDITVVTRRF---CQKCRLRKCLDIGMKSELLQLINLTAVAIKRLIKMAKKITAFRDMCQEDQVALLKGGCTEMMIMRSVMIYDDDRIYEEHQ---KFITTFDEKWRMDENIILIMCAIVLFTRVIHKDVIRLEQNSYYYLLRRYLESVYNAFIKLIQKISDVERLN Drosophila_melanogaster_DSF CKVCGDRSSGKHYGIYSCDGCSGFFKRSI----HRNR--IYT-CKA-TGDLKGRCPVDKTHRNQ---CRACRLAKCFQSAMNKDWEMLQETTARLLFMAVRWVKCLMPFQTLSKNDQHLLLQESWKELFLLNLAQWTIPLDEMKTIQ---EILCRFRQ-ITPDGSEVGCMKAIALFAGLCDVQPVEMLQDQAQCILSDHVRLRYTRFGRLLLLLPSLRTIR Drosophila_melanogaster_E75 CRVCGDKASGFHYGVHSCEGCKGFFRRSI----QQKI--QYRPCTK-NQ----QCSILRINRNR---CQYCRLKKCIAVGMSRDEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLICMFDSSILVDSTF---NFAERMNS-MNLTDAEIGLFCAIVLITGLRNLELIEKMYSRLKGCLQYIVAQNREFLAKLLETMPDLRTLS Drosophila_melanogaster_E78 CKVCGDKASGYHYGVTSCEGCKGFFRRSI----QKQI--EYR-CLR-DG----KCLVIRLNRNR---CQYCRFKKCLSAGMSRDWQQFSARVTPGVQRIVEFAKRVPGFCDFTQDDQLILIKLGFFEVWLTHVARLINEATFVNALL---NFANTLNA-YGLSDTEIGLFSAMVLLAGLSEPKVIGRARELVAEALRVQILRSRQLMPALEAKIPELRSLG Drosophila_melanogaster_EcR CLVCGDRASGYHYNALTCEGCKGFFRRSV----TKSA--VYC-CKF-GR----ACEMDMYMRRK---CQECRLKKCLAVGMRPEFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSNIEDLL---HFCRQMFS-MKVDNVEYALLTAIVIFSGLEKAQLVEAIQSYYIDTLRIYILNRHVFYAKLLSILTELRTLG Drosophila_melanogaster_FTZF1 CPVCGDKVSGYHYGLLTCESCKGFFKRTV----QNKK--VYT-CVA-ER----SCHIDKTQRKR---CPYCRFQKCLEVGMKLEFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLGDYFN---ELQNKLQD-LKFDMGDYVCMKFLILLNGIVNRKTVSEGHDNVQAALLDYTLTCYDKFRGLVNILPEIHAMA Drosophila_melanogaster_HNF4 CAICGDRATGKHYGASSCDGCKGFFRRSV----RKNH--QYT-CRF-AR----NCVVDKDKRNQ---CRYCRLRKCFKAGMKKEINDVCESMKQQLLTLVEWAKQIPAFNELQLDDQVALLRAHAGEHLLLGLSRRSMHLKIGARII--DELVTVMKD-VGIDDTEFACIKALVFFDGLNEPHRIKSLRHQILNNLEDYISDRQGRFGEILLILPVLQSIT Drosophila_melanogaster_SVP CVVCGDKSSGKHYGQFTCEGCKSFFKRSV----RRNL--TYS-CRG-SR----NCPIDQHHRNQ---CQYCRLKKCLKMGMRREIDNICELAARLLFSAVEWAKNIPFFPELQVTDQVALLRLVWSELFVLNASQCSMPLHHIRIFQ---EQVEKLKA-LHVDSAEYSCLKAIVLFTGLSDVTHIESLQEKSQCALEEYCRTQYTRFGKLLLRLPSLRTVS Drosophila_melanogaster_TLL CKVCRDHSSGKHYGIYACDGCAGFFKRSI----RRSR--QYV-CKS-QK--QGLCVVDKTHRNQ---CRACRLRKCFEVGMNKDAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNVTREVHAFQEVLNQLCH-LNIDSTEYECLRAISLFRGLLESGKVAAMHNDARSALHNYIQRTHMRFQTLLGVVQLMHKVS Drosophila_melanogaster_USP CSICGDRASGKHYGVYSCEGCKGFFKRTV----RKDL--TYA-CRE-NR----NCIIDKRQRNR---CQYCRYQKCLTCGMKREVSALCQVVNKQLFQMVEYARMMPHFAQVPLDDQVILLKAAWIELLIANVAWCSIVSLIFDRIL--SELSVKMKR-LNLDRRELSCLKAIILYNGIKSRAEIEMCREKVYACLDEHCRLEHGRFAQLLLRLPALRSIS Homo_sapiens_AR CLICGDEASGCHYGALTCGSCKVFFKRAA----EGKQ--KYL-CAS-RN----DCTIDKFRRKN---CPSCRLRKCYEAGMTLGLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVQCVRMR---HLSQEFGW-LQITPQEFLCMKALLLFSGLKNQKFFDELRMNYIKELDRIIACKRRRFYQLTKLLDSVQPIA Homo_sapiens_CAR CVVCGDQATGYHFNALTCEGCKGFFRRTV----SKSI--GPT-CPF-AG----SCEVSKTQRRH---CPACRLQKCLDAGMRKDVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTFLELLF---HFHGTLRK-LQLQEPEYVLLAAMALFSGVTQRDEIDQLQEEMALTLQSYIKGQQFLYAKLLGLLAELRSIN Homo_sapiens_COUPTF1 CVVCGDKSSGKHYGQFTCEGCKSFFKRSV----RRNL--TYT-CRA-NR----NCPIDQHHRNQ---CQYCRLKKCLKVGMRREIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHHIRIFQ---EQVEKLKA-LHVDSAEYSCLKAIVLFTGLSDAAHIESLQEKSQCALEEYVRSQYSRFGKLLLRLPSLRTVS Homo_sapiens_COUPTF2 CVVCGDKSSGKHYGQFTCEGCKSFFKRSV----RRNL--SYT-CRA-NR----NCPIDQHHRNQ---CQYCRLKKCLKVGMRREIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHHIRIFQ---EQVEKLKA-LHVDSAEYSCLKAIVLFTGLSDVAHVESLQEKSQCALEEYVRSQYTRFGKLLLRLPSLRTVS Homo_sapiens_EAR2 CVVCGDKSSGKHYGVFTCEGCKSFFKRSI----RRNL--SYT-CRS-NR----DCQIDQHHRNQ---CQYCRLKKCFRVGMRKEIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSELFVLNAAQAALPLHQVRAFQ---EQVDKLGR-LQVDSAEYGCLKAIALFTGLSDPAHVESLQEKAQVALTEYVRAQYQRFGRLLLRLPALRAVP Homo_sapiens_ERRa CLVCGDVASGYHYGVASCEACKAFFKRTI----QGSI--EYS-CPA-SN----ECEITKRRRKA---CQACRFTKCLRVGMLKEVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQLGAALL---QLVRRLQA-LRLEREEYVLLKALALANHIEDAEAVEQLREALHEALLEYEAGRARRAGRLLLTLPLLRQTA Homo_sapiens_ERRb CLVCGDIASGYHYGVASCEACKAFFKRTI----QGNI--EYS-CPA-TN----ECEITKRRRKS---CQACRFMKCLKVGMLKELTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDLYRAIL---QLVRRYKK-LKVEKEEFVTLKALALANYIEDLEAVQKLQDLLHEALQDYELSQRWRTGKLLLTLPLLRQTA Homo_sapiens_ERRg CLVCGDIASGYHYGVASCEACKAFFKRTI----QGNI--EYS-CPA-TN----ECEITKRRRKS---CQACRFMKCLKVGMLKELTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFELNNAIL---QLVKKYKS-MKLEKEEFVTLKAIALANHIEDVEAVQKLQDVLHEALQDYEAGQHRRAGKMLMTLPLLRQTS Homo_sapiens_ERa CAVCNDYASGYHYGVWSCEGCKAFFKRSI----QGHN--DYM-CPA-TN----QCTIDKNRRKS---CQACRLRKCYEVGMMKGMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPIFDMLL---ATSSRFRM-MNLQGEEFVCLKSIILLNSLEEKDHIHRVLDKITDTLIHLMAKAGQRLAQLLLILSHIRHMS Homo_sapiens_ERb CAVCSDYASGYHYGVWSCEGCKAFFKRSI----QGHN--DYI-CPA-TN----QCTIDKNRRKS---CQACRLRKCYEVGMVKCMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPIFDMLL---ATTSRFRE-LKLQHKEYLCVKAMILLNDADSSRKLAHLLNAVTDALVWVIAKSGMRLANLLMLLSHVRHAS Homo_sapiens_FXR CVVCGDRASGYHYNALTCEGCKGFFRRSI----TKNA--VYK-CKN-GG----NCVMDMYMRRK---CQECRLRKCKEMGMLAEFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLYITPMF---SFYKSIGE-LKMTQEEYALLTAIVILSYIKDREAVEKLQEPLLDVLQKLCKIHQQHFACLLGRLTELRTFN Homo_sapiens_GCNF CLICGDRATGLHYGIISCEGCKGFFKRSI----CNKR--VYR-CSR-DK----NCVMSRKQRNR---CQYCRLLKCLQMGMNRKFALLCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIVIERLI---YLYHKFHQ-LKVSNEEYACMKAINFLNGLTSASQLEQLNKRYWYICQDFTEYKYNRFPDLMMCLPEIRYIA Homo_sapiens_GR CLVCSDEASGCHYGVLTCGSCKVFFKRAV----EGQH--NYL-CAG-RN----DCIIDKIRRKN---CPACRYRKCLQAGMNLEMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSQCKHML---YVSSELHR-LQVSYEEYLCMKTLLLLSGLKSQELFDEIRMTYIKELGKAIVKREQRFYQLTKLLDSMHEVV Homo_sapiens_HNF4a CAICGDRATGKHYGASSCDGCKGFFRRSV----RKNH--MYS-CRF-SR----QCVVDKDKRNQ---CRYCRLKKCFRAGMKKEIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKVSIRIL--DELVLPFQE-LQIDDNEYAYLKAIIFFDGLSDPGKIKRLRSQVQVSLEDYINDRQGRFGELLLLLPTLQSIT Homo_sapiens_HNF4b CAICGDRATGKHYGASSCDGCKGFFRRSI----RKSH--VYS-CRF-SR----QCVVDKDKRNQ---CRYCRLRKCFRAGMKKEIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMYKVANRVL--DELVRPFQE-IQIDDNEYACLKAIVFFDGLSDPVKIKNMRFQVQIGLEDYINDRQGRFGELLLLLPTLQSIT Homo_sapiens_LRH CPVCGDKVSGYHYGLLTCESCKGFFKRTV----QNNK--RYT-CIE-NQ----NCQIDKTQRKR---CPYCRFQKCLSVGMKLEFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGLMSHAQ---ELVAKLRS-LQFDQREFVCLKFLVLFSNLENFQLVEGVQEQVNAALLDYTMCNYEKFGQLLLRLPEIRAIS Homo_sapiens_LXRa CSVCGDKASGFHYNVLSCEGCKGFFRRSV----IKGA--HYI-CHS-GG----HCPMDTYMRRK---CQECRLRKCRQAGMREEFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSFINPIF---EFSRAMNE-LQLNDAEFALLIAISIFSNVQDQLQVERLQHTYVEALHAYVSIHHLMFPRMLMKLVSLRTLS Homo_sapiens_LXRb CRVCGDKASGFHYNVLSCEGCKGFFRRSV----VRGGARRYA-CRG-GG----TCQMDAFMRRK---CQQCRLRKCKEAGMREQFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETFINPIF---EFSRAMRR-LGLDDAEYALLIAINIFSNVQEPGRVEALQQPYVEALLSYTRIKRLRFPRMLMKLVSLRTLS Homo_sapiens_MR CLVCGDEASGCHYGVVTCGSCKVFFKRAV----EGQH--NYL-CAG-RN----DCIIDKIRRKN---CPACRLQKCLQAGMNLGLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTLCQGMH---QISLQFVR-LQLTFEEYTIMKVLLLLSGLKSQAAFEEMRTNYIKELRKMVTKCPQRFYQLTKLLDSMHDLV Homo_sapiens_NGFIB CAVCGDNASCQHYGVRTCEGCKGFFKRTV----QKNA--KYI-CLA-NK----DCPVDKRRRNR---CQFCRFQKCLAVGMVKEVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEWIDSIL---AFSRSLHS-LLVDVPAFACLSALVLITGLQEPRRVEELQNRIASCLKEHVAAVASCLSRLLGKLPELRTLC Homo_sapiens_NOR1 CAVCGDNAACQHYGVRTCEGCKGFFKRTV----QKNA--KYV-CLA-NK----NCPVDKRRRNR---CQYCRFQKCLSVGMVKEVQQFYNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEWLDSIK---DFSLNLQS-LNLDIQALACLSALSMITGLKEPKRVEELCNKITSSLKDHQSKGQ-TESKVLGALVELRKIC Homo_sapiens_NURR1 CAVCGDNAACQHYGVRTCEGCKGFFKRTV----QKNA--KYV-CLA-NK----NCPVDKRRRNR---CQYCRFQKCLAVGMVKEIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEWIDSIV---EFSSNLQN-MNIDISAFSCIAALAMVTGLKEPKRVEELQNKIVNCLKDHVTFNNNYLSKLLGKLPELRTLC Homo_sapiens_PNR CRVCGDSSSGKHYGIYACNGCSGFFKRSV----RRRL--IYR-CQV-GA---GMCPVDKAHRNQ---CQACRLKKCLQAGMNQDLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDETRVLQ---ETISRFRA-LAVDPTEFACMKALVLFKGLKDPEHVEALQDQSQVMLSQHSKAHHVRFGKLLLLLPSLRFIT Homo_sapiens_PPARa CRICGDKASGYHYGVHACEGCKGFFRRTI----RLKL--VYDKC---DR----SCKIQKKNRNK---CQYCRFHKCLSVGMSHNFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGIMEPKF---DFAMKFNA-LELDDSDISLFVAAIICCGLLNVGHIEKMQEGIVHVLRLHLQSNHFLFPKLLQKMADLRQLV Homo_sapiens_PPARb CRVCGDKASGFHYGVHACEGCKGFFRRTI----RMKL--EYEKC---ER----SCKIQKKNRNK---CQYCRFQKCLALGMSHNFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGIIEPKF---EFAVKFNA-LELDDSDLALFIAAIILCGLMNVPRVEAIQDTILRALEFHLQANHYLFPKLLQKMADLRQLV Homo_sapiens_PPARg CRVCGDKASGFHYGVHACEGCKGFFRRTI----RLKL--IYDRC---DL----NCRIHKKSRNK---CQYCRFQKCLAVGMSHNFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGFMEPKF---EFAVKFNA-LELDDSDLAIFIAVIILSGLLNVKPIEDIQDNLLQALELQLKLNHQLFAKLLQKMTDLRQIV Homo_sapiens_PR CLICGDEASGCHYGVLTCGSCKVFFKRAM----EGQH--NYL-CAG-RN----DCIVDKIRRKN---CPACRLRKCCQAGMVLGLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVLCLTMW---QIPQEFVK-LQVSQEEFLCMKVLLLLNGLRSQTQFEEMRSSYIRELIKAIGLRQQRFYQLTKLLDNLHDLV Homo_sapiens_PXR CRVCGDKATGYHFNVMTCEGCKGFFRRAM----KRNA--RLR-CPFRKG----ACEITRKTRRQ---CQACRLRKCLESGMKKELPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETLLEPML---KFHYMLKK-LQLHEEEYVLMQAISLFSGVLQHRVVDQLQEQFAITLKSYIECNRFLFLKIMAMLTELRSIN Homo_sapiens_RARa CFVCQDKSSGYHYGVSACEGCKGFFRRSI----QKNM--VYT-CHR-DK----NCIINKVTRNR---CQYCRLQKCFEVGMSKEWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQLTDLVF---AFANQLLP-LEMDDAETGLLSAICLICDLEQPDRVDMLQEPLLEALKVYVRKRRHMFPKMLMKITDLRSIS Homo_sapiens_RARb CFVCQDKSSGYHYGVSACEGCKGFFRRSI----QKNM--IYT-CHR-DK----NCVINKVTRNR---CQYCRLQKCFEVGMSKEWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQLTDLVF---TFANQLLP-LEMDDTETGLLSAICLICDLEEPTKVDKLQEPLLEALKIYIRKRRHMFPKILMKITDLRSIS Homo_sapiens_RARg CFVCNDKSSGYHYGVSSCEGCKGFFRRSI----QKNM--VYT-CHR-DK----NCIINKVTRNR---CQYCRLQKCFEVGMSKEWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQLTDLVF---AFAGQLLP-LEMDDTETGLLSAICLICDLEEPEKVDKLQEPLLEALRLYARRRRYMFPRMLMKITDLRGIS Homo_sapiens_RORa CKICGDKSSGIHYGVITCEGCKGFFRRSQ----QSNA--TYS-CPR-QK----NCLIDRTSRNR---CQHCRLQKCLAVGMSRDWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNFISFVF---EFGKSLCS-MHLTEDEIALFSAFVLMSWLQEKVKIEKLQQKIQLALQHVLQKNHGILTKLICKVSTLRALC Homo_sapiens_RORb CKICGDKSSGIHYGVITCEGCKGFFRRSQ----QNNA--SYS-CPR-QR----NCLIDRTNRNR---CQHCRLQKCLALGMSRDWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNLVNEAF---DFAKNLCS-LQLTEEEIALFSSAVLISWLIEPRKVQKLQEKIYFALQHVIQKNHETLAKLIAKIPTITAVC Homo_sapiens_RORg CKICGDKSSGIHYGVITCEGCKGFFRRSQ----RCNA--AYS-CTR-QQ----NCPIDRTSRNR---CQHCRLQKCLALGMSRDWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNLISSIF---DFSHSLSA-LHFSEDEIALYTALVLINGLQEKRKVEQLQYNLELAFHHHLCKTH--RQSILAKLPPLRSLC Homo_sapiens_RXRa CAICGDRSSGKHYGVYSCEGCKGFFKRTV----RKDL--TYT-CRD-NK----DCLIDKRQRNR---CQYCRYQKCLAMGMKREVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKIFDRVL--TELVSKMRD-MQMDKTELGCLRAIVLFNGLSNPAEVEALREKVYASLEAYCKHKYGRFAKLLLRLPALRSIG Homo_sapiens_RXRb CAICGDRSSGKHYGVYSCEGCKGFFKRTI----RKDL--TYS-CRD-NK----DCTVDKRQRNR---CQYCRYQKCLATGMKREVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRIFDRVL--TELVSKMRD-MRMDKTELGCLRAIILFNGLSNPSEVEVLREKVYASLETYCKQKYGRFAKLLLRLPALRSIG Homo_sapiens_RXRg CAICGDRSSGKHYGVYSCEGCKGFFKRTI----RKDL--IYT-CRD-NK----DCLIDKRQRNR---CQYCRYQKCLVMGMKREVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQIFDRVL--TELVSKMKD-MQMDKSELGCLRAIVLFNGLSNPSEVETLREKVYATLEAYTKQKYGRFAKLLLRLPALRSIG Homo_sapiens_Reverba CKVCGDVASGFHYGVHACEGCKGFFRRSI----QQNI--QYKRCLK-NE----NCSIVRINRNR---CQQCRFKKCLSVGMSRDWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDLLSAMF---DFSEKLNS-LALTEEELGLFTAVVLVSGMENSASVEQLQETLLRALRALVLKNRSRFTKLLLKLPDLRTLN Homo_sapiens_Reverbb CKVCGDVASGFHYGVHACEGCKGFFRRSI----QQNI--QYKKCLK-NE----NCSIMRMNRNR---CQQCRFKKCLSVGMSRDWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKELLNSMF---EFSEKLNA-LQLSDEEMSLFTAVVLVSGIENVNSVEALQETLIRALRTLIMKNHSIFTKLLLKLPDLRSLN Homo_sapiens_SF1 CPVCGDKVSGYHYGLLTCESCKGFFKRTV----QNNK--HYT-CTE-SQ----SCKIDKTQRKR---CPFCRFQKCLTVGMRLEFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGLVLRAQ---ELVLQLLA-LQLDRQEFVCLKFIILFSFLNNHILVKDAQEKANAALLDYTLCHYDKFQQLLLCLVEVRALS Homo_sapiens_THRa CVVCGDKATGYHYRCITCEGCKGFFRRTI----QKNLHPTYS-CKY-DS----CCVIDKITRNQ---CQLCRFKKCIAVGMAMDFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESVSDAIF---ELGKSLSA-FNLDDTEVALLQAVLLMSGLLCVDKIEKSQEAYLLAFEHYVNHRKHFWPKLLMKVTDLRMIG Homo_sapiens_THRb CVVCGDKATGYHYRCITCEGCKGFFRRTI----QKNLHPSYS-CKY-EG----KCVIDKVTRNQ---CQECRFKKCIYVGMATDFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESVSDAIF---DLGMSLSS-FNLDDTEVALLQAVLLMSGLACVERIEKYQDSFLLAFEHYINYRKHFWPKLLMKVTDLRMIG Homo_sapiens_TLX CKVCGDRSSGKHYGVYACDGCSGFFKRSI----RRNR--TYV-CKS-GN--QGGCPVDKTHRNQ---CRACRLKKCLEVNMNKDTESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDEIQALQ---EVVARFRQ-LRLDATEFACLKCIVTFKSFRNAAAIAALQDEAQLTLNSYIHTRYCRFGKLLLLLPALRSIS Homo_sapiens_TR2 CVVCGDKASGRHYGAVTCEGCKGFFKRSI----RKNL--VYS-CRG-SK----DCIINKHHRNR---CQYCRLQRCIAFGMKQDVHYIGESASRLLFLSMHWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNLMEHIFKLQEFCNSMVK-LCIDGYEYAYLKAIVLFSSLENMEQIEKFQEKAYVEFQDYITKTYYRLSRLLLRLPALRLMN Homo_sapiens_TR4 CVVCGDKASGRHYGAVSCEGCKGFFKRSV----RKNL--TYS-CRS-NQ----DCIINKHHRNR---CQFCRLKKCLEMGMKMEVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSVMEHIWKLQEFCNSMAK-LDIDGYEYAYLKAIVLFSGLTSTSQIEKFQEKAQMELQDYVQKTYYRLARILVRLPALRLMS Homo_sapiens_VDR CGVCGDRATGFHFNAMTCEGCKGFFRRSM----KRKA--LFT-CPF-NG----DCRITKDNRRH---CQACRLKRCVDIGMMKELPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDLIEPLI---KFQVGLKK-LNLHEEEHVLLMAICIVSGVQDAALIEAIQDRLSNTLQTYIRCRHLLYAKMIQKLADLRSLN Lymnaea_stagnalis_RAR CVVCNDKSSGYHYGVSSCEGCKGFFRRSV----QKNM--QYT-CHK-EK----NCVINKVTRNR---CQYCRLQKCVVMGMSKEWEKITELSSAGIVMIVDFAKKIPGFLSLSTSDQITLLKAACLEIMILRISIRYELDTLTSTIF---SFAASLKR-MNCDETEYAMLSSICLISGLHDTEKIEQMQEPLLEALKHYIRSRRHTFAKMLMKLTDLRSIS Lymnaea_stagnalis_RXR CAICGDRASGKHYGVYSCEGCKGFFKRTV----RKDL--TYA-CRD-DK----NCMIDKRQRNR---CQYCRYMKCLSMGMKREVTNICQAADKQLFTLVEWAKRIPHFTELPLEDQVILLRAGWNELLIAGFSHRSIMAKIFDRVL--TELVAKMRE-MKMDKTELGCLRAVVLFNGLTAVQEVEQLREKVYASLEEYTKTRYGRFAKLLLRLPALRSIG Marisa_cornuarietis_ER CQVCNDNASGFHYGVWSCEGCKAFFKRSI----QGPV--DYM-CPA-TN----NCTIDKHRRKS---CQACRLRKCYEVGMNKGLNTLIKLADRELVYLINWAKHVPGYTDLSLSDQVHLIECCWMELLLLNCAFRSMDHEILEQVG---AVSEQMVQ-YSVSKEELLLLQATVLVNRLASYSKIGEMQQMIVDALMDIAQRTHRHVPSLILLLTHIRQAG Marisa_cornuarietis_ERR CLVCGDVASGYHYGVSSCEACKAFFKRTI----QGNI--EYS-CPA-SG----ECEITKRRRKA---CQACRFQKCLRVGMLRERAAVSDLADRELVITISWAKQVPGFTNLSLMDQMNLLQHSWLEILCLNLVFRSCPYNLDSLTR---KLCKKFTY-LGVSKEEYVLLKAIILCNVVETGETVRGLQDKLQDSLIECIKARHRRLGQLFLLLPPITHIK Mytilus_edulis_ER CQVCSDNASGFHYGVWSCEGCKAFFKRSI----QGPV--DYV-CPA-TN----SCTIDKHRRKS---CQACRLRKCYEVGMNKGLNSLVKLAERELVQLINWAKNVPGYIDLSLSDQVHLIECCWMELLLLNCTFRSMSYNIFEQVS---AVSENFIQ-YQLHKNESLLLQATVLVNRLTSCDKIHRMRQSILDAVVDTAQKYHRHVPSILLMLTHIRQAG Mytilus_galloprovincialis_NR1DEF -----------------CEGCKGFFRRCI----TQGM--THK-CSN-EE----KCEITPFTRNS---CQYCRLKKCFAVGMSREWEQFVQNMVPEITMVVKFCKKIPGFNEICQEDQINLIKQGSFEVMLVRMCNLVDTEKFLVEFF---KVAKAFNP-LQLTDGEIGIFTATLIICSIINSVAIMKLQLLLMQALYVLIKKNHSLFIELMKRIPIFRGIN Mytilus_galloprovincialis_NR1Dv1 CRVCGDKASGFHYGVHACEGCKGFFRRSI----QQKI--QYRPCLK-NQ----QCNIMRVNRNR---CQYCRLKKCIAVGMSRDWEDFYDFYTPAIISVVNFAKSVPGFCILNQDDQVTLLKAATFEVLLVRHACLFDTDNLLDSMF---DFAERFNM-LKLAEEEIALFSAIVLLSGLRNVEQIEKLQNKLTESLQTVINTNHTLFAKLLMKTTNLRTLN Mytilus_galloprovincialis_NR1G CRVCGQKASGFHYGANTCEACKGFFRRSIVKIIKKKE--TYK-CSK-DK----NCPIGPGRRAM---CAFCRYKKCLDIGMSQEMGKIATSMEKNIRNIVEFVRLIPGYSQLSTKDRLQLIKSCFSDYWFLAAHKRINLELYLDEIC---QVTTKLQK-CNMTIEEVTLLRAITLTADLENPAKVEEIQWKLISFLRSLLKKSYQRLWQLFDIMTSLRNL- Nucella_lapillus_ER CQVCNDNASGFHYGVWSCEGCKAFFKRSI----QGPV--DYM-CPA-TN----NCTIDKHRRKS---CQACRLRKCYEVGMNKGLNTLIKLADRELVYLINWAKHVPGYTDLSLSDQVHLIECCWMELLLLNCAFRSMDYDILEQVS---AVTEQMVQ-YTVTKEELLLLKATILVNRLASMDKIVEMRQMIVDALTEVAQKSHRRVPCLLLLLTHVRQAG Nucella_lapillus_RXR CAICGDRASGKHYRVYSCEGCKGFFKRTV----RKDP--TYA-CRD-DK----NCMIDKRQRNR---CQFCRYMKCLAQGMKREVTNICQAADKQLFTLVEWAKRIPHFIELPLEDQVILLRAGWNELLIAGFSHRSTQVTIFDRVL--TELVAKMRE-MKMDKTELGCLRAIVLFNGLQAVQEVEQLREKVYASLEEYCKQRYGRFAKLLLRLPALRSIG Octopus_vulgaris_ER CQVCDDNASGFHYGVWSCEGCKAFFKRSI----QGPV--DYV-CPA-TN----SCTIDKHRRKS---CQACRLRKCYEVGMNKGLQLLIQVADKDLVQLINWAKHIPGYADLSLSDQVHLIECCWMELVLLNCAYRSMEYEILEQVA---AVSEQLLQ-FGINREELLLLEATILVNRLAGFSKIDDIRQIILNALIDTAQKYHRHVPSALLLLSHVRQAS Thais_clavigera_ER CQVCNDNASGFHYGVWSCEGCKAFFKRSI----QGPV--DYM-CPA-TN----NCTIDKHRRKS---CQACRLRKCYEVGMNKGLNTLIKLADRELVYLINWAKHVPGYTDLSLSDQVHLIECCWMELLLLNCAFRSMDYDILEQVS---AVTEQMVH-YAVTKEEQLLLKATILVNRLASFDKIMEMRQMIVDALMEVAQKSHRRVPSLLLLLTHVRQAG Thais_clavigera_RXR CAICGDRASGKHYGVYSCEGCKGFFKRTV----RKDL--TYA-CRD-DK----NCMIDKRQRNR---CQYCRYMKCLAQGMKREVTNICQAADKQLFTLVDWAKRIPHFVELPLEDQVILLRAGWNELLIGGFSHRSTQVTIFDRVL--TELVAKMRE-MKMDKTELGCLRAIVLFNGLQSVQEVEQLREKVYASLEEYCKQRYGRFAKLLLRLPALRSIG ; END;