#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 19, 2025; 0:33 GMT TreeBASE (cc) 1994-2008 Study reference: Ternes C.M., & Schoenknecht G. 2014. Gene transfers shaped the evolution of de novo NAD+ biosynthesis in eukaryotes. Genome Biology and Evolution, . TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S15669] BEGIN TAXA; TITLE Taxa; DIMENSIONS NTAX=139; TAXLABELS Acetohalobium_arabaticum_302391850 Albugo_laibachii_325192082 Alistipes_putredinis_167752802 Allomyces_macrogynus_AMAG_16286.2 Amphimedon_queenslandica_340380825 Anolis_carolinensis_327286062 Aplanochytrium_kerguelense_Aplke1_71850 Aplysia_californica_524891882 Arabidopsis_thaliana_18379203 Ashbya_gossypii_302308777 Aspergillus_fumigatus_71000697 Aspergillus_nidulans_259485580 Aurantiochytrium_limacinum_Aurli1_47555 Aureococcus_anophagefferens_323450966 Bacillus_licheniformis_52081266 Bacillus_pumilus_489308961 Bacillus_pumilus_515937137 Bacillus_sp_493892095 Bacteroides_fragilis_492201930 Bacteroides_sp_262383577 Bathycoccus_prasinos_424513657 Batrachochytrium_dendrobatidis_328768375 Bigelowiella_natans_Bigna1_87812 Botryotinia_fuckeliana_154302740 Brachypodium_distachyon_357159945 Branchiostoma_floridae_260820596 Brevibacillus_laterosporus_550166487 Canis_lupus_73958447 Capitella_teleta_443726530 Chitinophaga_pinensis_256034427 Chlamydomonas_reinhardtii_159473679 Chlorella_variabilis_307110653 Chlorobium_luteolum_78186158 Chlorobium_phaeobacteroides_119358065 Chlorobium_tepidum_21674748 Chloroherpeton_thalassium_193213974 Chondrus_crispus_546298846 Chrysemys_picta_530651528 Ciona_intestinalis_198427547 Coccomyxa_subellipsoidea_545355350 Cohnella_laeviribosi_517835836 Colletotrichum_graminicola_310797743 Crassostrea_gigas_405970213 Cryptococcus_neoformans_58264948 Cyanidioschyzon_merolae_544214606 Cyanothece_sp_495549546 Debaryomyces_hansenii_294659145 Desulfotomaculum_ruminis_334338847 Dictyostelium_discoideum_74876284 Dictyostelium_fasciculatum_470247366 Dictyostelium_purpureum_330845892 Ectocarpus_siliculosus_298708640 Flavobacterium_johnsoniae_146301230 Fusarium_graminearum_46136067 Galdieria_sulphuraria_545706519 Geitlerinema_sp_516256703 Geminocystis_herdmanii_515863331 Gloeocapsa_sp_434395003 Halarchaeum_acidiphilum_545903776 Halococcus_morrhuae_490156868 Haloquadratum_sp_544619543 Halorubrum_coriense_493053117 Halorubrum_sp_544625340 Halosarcina_pallida_495660202 Heliobacillus_mobilis_27262196 Helobdella_robusta_555695892 Homo_sapiens_119600420 Komagataella_pastoris_254572087 Kyrpidia_tusciae_295694784 Laccaria_bicolor_170090746 Latimeria_chalumnae_557006856 Leptolyngbya_sp_427724983 Lottia_gigantea_556108132 Marivirga_tractuosa_313676446 Medicago_truncatula_217072004 Meyerozyma_guilliermondii_190346853 Microcystis_aeruginosa_488885608 Micromonas_pusilla_303271165 Micromonas_sp_255080870 Mixia_osmundae_358057313 Monodelphis_domestica_126334616 Mortierella_verticillata_MVEG_07206.1 Mucor_circinelloides_511011227 Mus_musculus_19526852 Nannochloropsis_gaditana_422293510 Natronomonas_moolapensis_452207189 Nematostella_vectensis_156373006 Neurospora_crassa_16945374 Nodosilinea_nodulosa_515868781 Oreochromis_niloticus_542187933 Oryza_sativa_115480575 Ostreococcus_tauri_308802007 Paenibacillus_dendritiformis_493728944 Paenibacillus_elgii_498187320 Paenibacillus_ginsengihumi_518366183 Paenibacillus_polymyxa_310639532 Paenibacillus_sanguinis_517583346 Paenibacillus_sp_251794106 Paenibacillus_sp_546577354 Pedobacter_saltans_325104754 Pedobacter_sp_149280739 Phaeodactylum_tricornutum_219129720 Physcomitrella_patens_168048902 Phytophthora_infestans_301091078 Phytophtora_ramorum_JGI_2507657097 Polysphondylium_pallidum_281204821 Populus_trichocarpa_224101821 Porphyridium_purpureum_contig_548.3 Prevotella_sp_546844924 Pyrenophora_teres_311319941 Rhizophagus_irregularis_552921220 Rhizopus_delemar_384494577 Rhodothermus_marinus_345302083 Ricinus_communis_255570096 Saccharomyces_cerevisiae_19705600 Saccoglossus_kowalevskii_291224699 Salisaeta_longa_551207634 Salpingoeca_rosetta_326430421 Scheffersomyces_stipitis_126138416 Schizochytrium_aggregatum_Schag1_96276 Schizophyllum_commune_302696823 Selaginella_moellendorffii_302794630 Sorghum_bicolor_242045540 Spizellomyces_punctatus_SPPG_08064.3 Synechococcus_elongatus_56750600 Synechococcus_sp_170076994 Synechococcus_sp_427714595 Takifugu_rubripes_410932074 Thalassiosira_pseudonana_224008214 Thermobacillus_composti_430751789 Trametes_versicolor_392568318 Trichoplax_adhaerens_196001563 Ustilago_maydis_71020357 Vitis_vinifera_297737712 Volvox_carteri_302845584 Xenopus_tropicalis_301622624 Yarrowia_lipolytica_50552482 Zygosaccharomyces_rouxii_254583213 halophilic_archaeon_544604960 ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M21785] TITLE 'Nicotinate-Nucleotide Pyrophosphorylase Alignment'; LINK TAXA = Taxa; DIMENSIONS NCHAR=352; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 ] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] Acetohalobium_arabaticum_302391850 --------M-----------L-----MLAEDIGTGDLT-EAV-DQQVQG---LIAKEEGVIAGLAVAGLIFAK-I---YQ-Q--EGVRVRP-TVI-TISG-LAAILTGERVALNFLQRLSGIATKTAQYAELV---YD-RIVDTRKTTPGLRMLEKYAVRVGGGFNHRCGLYDAVLIKDNHIQVVGS-TEAV---EQAK-----HT------EVEVETLAEVKEALASG--I--IMLDNM-----------PE----L-MEKA----------GLI--GT-TEASGGITAE-IKEV--AQAGVDIISLGT-THTISALDISL--L-------SDN---------R------- Albugo_laibachii_325192082 --AP-C-MAH-PPTWK--VQ----MW-LEDDIPSFDIGGY--VVGETEE-ALLYGKSNGILAGVPFFEEIFSTLC---VHWKFAEGSKIDIKV--AEITGKCRNILLGERTALNILTRASGIATQALATL-VAEAGWNGHVAGTRKTTPGFRLVEKYALLVAGVSTHRHDLSQMVMLKDNHVWAAGSITKAV---GCAK-QVAGFHMKI---EVECQNLKEAQEAAIAGADI--VMLDN------------PE-------RSA---------AQV-KFPLLIEASGG----I-TNIEYTSPHVDIISQG---QGYPCLDFSL--I--------------------------- Alistipes_putredinis_167752802 -------MY-----------P------IREDIGDGDHT-LCC-PATEKG-MRLLCKQEGILAGIEIAQLV-RR----QFE-I--DGDRVKP--DVAYVSGRLQSLLQAERILLNIMQRMSGVATQTAVYANKI---LH-KVLDTRKTTPGMRVLDKMAVKIGGGENHRMGLFDMILLKDNHIDFAGG-RPAI----GAK---------AGKNECEVRSLEDIDEVFA-GV-R--IMFDNF------------E----L-TRQA---------VAKV--G--TESSGGITLDT-REY--AETGVDFISVGA-THQIKSLDMSL--A--------------------------- Allomyces_macrogynus_AMAG_16286.2 ---S----AHLPPSWK--VA----AW-LAEDIPSFDYGGF--VVG--DKDATLWCKANGVLAGVPFVDEIFKQ-VDCRVEWIAKEGEFID-KV-VAKVYGQARNLLLGERTALNLMARCSGIATRARRMA-LKKHGFKGVIAGTRKTTPGFRHVEKYGMLVGGVDQHRMDLSSMIMLKDNHVWSSGSITKAV---QKAR-QVGGFALKI---EVECRSIAEAEEAITAGADI--VMLDN---------------------PDSKTAAVDLKRYP-----VLIEGSGGITEET-Y-S----PGVDVLSMGS--QGVPFIDFSL--I--------------------------- Amphimedon_queenslandica_340380825 ---E---ST-LSPAI---VR----GW-IKEDMPSFDYAGI--VVGDKIE-AAIIAKSPGVLSGVPFVESVFSQ-LDCKVTWLCKEG-KV-LMS-VARVKGPAYKLLKGERIALNVLARSSGIATHARELSELADLKWAGEIAGTRKTTPGFRQVEKYSLLVGGVSTHRYDLSSLIMLKDNHIWVSGSVSEAI---KRAR-SVGGFSLKI---EVECRSLAEAEEAILSGAEI--VMLDN------------PE-------------------ARH-KYPVTIEASGGIRRDTLAQY--CLP-VDVISLS---QGYASVNYSL-------------KERDPLNPVA------- Anolis_carolinensis_327286062 ----RGF--HLPAALR--AK----DW-LQEDAPSFDYGGY--AVGNR-S-AVLLCKSPGVLAGFPFFEAIFAE-VGCSVEWLQSEGVWVEPIT-VAEVRGQAKDILLGERVALNCLGRCSGVATLATKAC-AAEVGWHGEVAGTRKTTPGFRLAEKYALLVGGASCHRYDLGSLVMLKDNHVWASGSITQAV---HSAR-RVGGFALKV---EVECRSLEEAIEAAECGSDI--IMLDN------------IQ-------HPT---------AKT-KFPVTVEASGGITEE-ITQF--VGP-IDVVSLG--TQSAKVVDFSL----------------------RN------ Aplanochytrium_kerguelense_Aplke1_71850 ---E---SE--PPIVR--IK----GW-LKTDVPSFDIGGF--VVGK--KEALLLGKSPGVICGAEFAKIVFDI-MNLRVEW-YKDG-KI-P-K-IAKVTGEVRSILLAERTALNIMARSSGIATEARKMRDLGAEKWHGEVAGTRKTTPGFSFIEKYSLLVGGVSTHRLDLSQMTMLKDNHVLSAGSISKAV---YKAR-SVAGFSSKI---EVECSTYAEAEEACKAGAEI--VMLDN---PELKVAKKD---------------------------PVIIEASGGITEETIY----MSD-VDVISMG---QGYGALDFSL------------------------------ Aplysia_californica_524891882 ----S-VL-LLTPTLK--VR----EW-FKEDTPSFDYAGF--VVGEKEE-AVILMKEAGVFAGKPFVDAIFKE-LDCLVEWHVEEGEYIEPIK-IATVTGKVRHLLLGERVALNCITRASGIATMARAKI-AS-RGWSGEVAGTRKTTPGFRLVEKYALLVGGVSTHRHDLSSMIMLKDNHIWTAGSITQAV---KDAR-VVGGFSTKI---EVECRSVQEATEAAQAGSEI--VMLDN------------PE-------EQA---------AKE-KFPLIIEISGGITEE-LANY--CVD-VDVISVG--TQGYKTIDLSF-------------KAKDPSNPV-------- Arabidopsis_thaliana_18379203 ----------------F---SSHPAV-LAEDAGHGDVT-MAT-PFDMEV-AYFLAKEDGIVAGVALADMI-EH-V--KVE-M--DGDYVHKGLKF-KVSGNAHKIVVAERVLLNFMQRMSGIATLTKLMAD-----SP-CILETRKTAPGLRLVDKWAVLIGGGRNHRMGLFDMVMIKDNHISAAGGIVNAV------------EY--QNLEEVETRTLEEVKEVL--GT--TRIMLDNM------------ENGDVM-LKDA---------VELIN-G--TEASGNVTLET-HKI--GQSGVTFISSGA-THSVKALDISLKDEG------------------R------- Ashbya_gossypii_302308777 ---P-E-FKNLPANWK--IT----NW-LQEDVPAFDYGGY--VVGSATK-ATLLCKQKGVLAGVPFADEVFRQ-CNLECQWLFVEGDEL-PKI-VAKVTGEARNILLAERTALNILSRCSGIASASRNII-SAAAGYRGTVAGTRKTTPGLRRLEKYAMLVGGCDTHRYDLSSMVMLKDNHIWATGSITRAV---QDAR-AACGFTIKI---EVECQSEAEADEAIAAGADV--IMLDNFTGLRTAQLKWA---------KN-----------------FLLECSGGL---RIL--EYLCQ-IDIYSTS--HQGTPVVDFSL------------------------------ Aspergillus_fumigatus_71000697 ---S-V-LRHLPNNYK--IT----AW-LEEDCPSFDYGGF--VVGESEG-ARLLGKSKGVVAGVPFFDEVFSQLCT--VEWHVKEGESI--KH--ATVRGPIRQILLGERVALNILARCSGIATKSTTLV-ALAHGWQGTLAGTRKTTPGFRVVEKYGLLVGGADPHRHDLSSMTMLKDNHVWASGAIPRAV---QAAK-AAGGFSTKV---EVECRSLEEANAAIDAGADV--IMLDN----------PE---------RDARQLKQDWAKQK-----FLVEVSGGLTEANAY-----CP-VDILSTS--HQGTPIVDFSL------------------------R----- Aspergillus_nidulans_259485580 ---S-A-LRHLPATYK--IS----DW-LEEDCPSFDYGGF--VVGESEG-AKLLGKSEGIIAGVPFFDEVFSQLCS--VEWHHHEGSSL--KT-VATVRGPIRKILLGERVALNILARCSGIATKTSSLL-ILSHGWKGTLAGTRKTTPGFRVVEKYGILVGGADPHRHDLSSMTMLKDNHVWATAAIPKAV---QAAK-AVGGFATKV---EVEVRSLDEANAAIEAGADV--VMLDN--------TSVR---------AKQKEEWTAKGSRG-----FLIEVSGGLNEVNAY-----CD-VDIFSTS--HQGVGIVDFSL------------------------R----- Aurantiochytrium_limacinum_Aurli1_47555 ---P---FA-LPPH-R--VR----GW-LVADAPEFDVGGF--VVG-DVR-AMLLGKSPGVIAGVPFAQAVFDA-VGVSVEWLIKDGVIS--RK-LAKVRGPARKILMAERTVLNIMTRASGIATASRRM-ALVEHNWHGEVAATRKTTPGFSLVEKYAVLVGGCSTHRMTLSHMVMLKDNHVWSVGDITKAV---HKAR-AAAGFSSKI---EVECRNLEEAVEACQAGAEV--VMLDN---PELKEAAKE---------------------------PVTIEASGGITEDTAF----FSK-VDVLSMG---QGYECLDLSL-------------KE--------------- Aureococcus_anophagefferens_323450966 ---M---FAC-PPYER--AD-----W-LRDDCPSLDVGGL--VVGDGVT-ATLWCKSSGVLAGKPFFDATFAA-LGCVVTWLVDEGAA-IDCAGAATVVGPARKLLLGERTALNALSRASGVASAAKRAV-VASVGWRGTVAGTRKTTPGFRIVEKYALLIGGAGTHRLDLSQMVMLKDNHVWAAGSITTAV---TTAK-RAAGFSAKI---EVECRDLGEALEAAAAGADV--VMLDN------------PA-------KVA---------AKA-KHPVLVEASGGITLDTMASY---SPDVDVVSQG---QGYACVDFSL--L--------------------------- Bacillus_licheniformis_52081266 --------M-----------R------FKEDIGRGDLT-EAV-DDNHQC-AVITAKDDGLFAGLVILEG-FRL-L--AVH-L--DGEAVRK-ETI-RLKGRAASLMTGERVVLNLIQRMSGIATLTKQSIIRL---PN-AICDTRKTTPGLRILEKYAVKTGGGSNHRFGL-DGIMIKDNHIAACGS-SKAV---EKAR-----HM------EVEIESEQELHEAIEAG--I--IMFDNC-----------PE----T-VK-A----------AEMP-G-I-EASGGISFE-LPAY--RGTGVHCISLGY-THSAKSLDISM--V-------------------K------- Bacillus_pumilus_489308961 --------M------------------FTEDIGFGDVS-DGI-GEK-KG-AYIIAKQSGVLAGSQVIDIGYRL-L--Q-T-L--EGDWIHS-AVL-KIKGPVSDLLKGERVILNVLQRMTGIATLTHEAVQRL---PS-TICDTRKTTPGLRMLEKYAVKTGGGKNHRFGLSDGVMIKDNHIAACGS-REAV---EKAR-----HM------EVEIESETQLKEAIDAK--V--IMFDNC-----------DE--------------------KRF--QTPLEASGGITLE-LPSY--RGTGVDLISLGF-THSAPAFDFSM--M-EFSHKGGTT---------T------- Bacillus_pumilus_515937137 --------M------------------LKEDIGFGDVS-DAI-FGDKKG-AYIMAKQSGVLAGTQVIDMGYKL-L--Q-T-L--EGDWIHE-AVL-QITGPVNDLLKGERVVLNILQRMTGIATLTHEAVERL---PS-TICDTRKTTPGLRMLEKYAVKVGGGKNHRFGLSDGVMIKDNHIAACGS-REAV---EKAR-----HM------EVEIESEAQLMEAIDAK--V--IMFDNC-----------DE--------------------KRF--QTPLEASGGITLE-VANY--RGTGVDLISLGF-THSAPSFDFSM--M-EFSHKGGTT---------H------- Bacillus_sp_493892095 ---------------------------L-EDIGDGDLS-ALF-MKDYSTFFVV--KEAGVFCGKDVIISGFSI-L--DVT-Y--DGEKVEP-TVI-EATGPAADLLQAERVILNLVQRMSGIATVTAEVVNLV---HP-RICDTRKTTPGLRMLEKYAVRCGGGFNHRNGLYDAVMLKDNHISFKGS-NAAV---NEVK-----HT------EVEIETRDGLREAVESG--I--IMFDNR-----------QE------IAEW----------EDV--PII-EASGGIQKE-VADY--ARTGVQYISLGF-THSVKGLDISA--VQGGIESEFIT---------K------- Bacteroides_fragilis_492201930 ------------------------LI-A-EDIGDGDHT-LSC-PATAMG-SKLLIKEAGVLAGIEIAKEI-HR----KVE-F--DGAEVKP--DVAMVEGKIQSLLQTERLMLNVMQRMSGIATMTRKYVKQL---TK-RVLDTRKTTPGLRMLEKAAVKIGGGVNHRIGLFDMILLKDNHVDFAGG-DKAI----RAKC----D-------EIEVRNFDELQQVLNIG--R--IMFDNF------------E----N-TKKA---------VEMI--G--TESSGGITFDT-RDY--AECGVDFISVGA-THSVKGLDMSF--A--------------------------- Bacteroides_sp_262383577 --------------------D------FAEDIGDGDHT-LCC-PETAMG-SQLIIKEDGVLAGVEMAKRI-HD----KMT-F--DGAEVKK--DIAFVEGKIQSLLQTERLMLNVMQRMSGIATTTRKYAKAL---TK-HVLDTRKTTPGMRMIEKEAVRIGGGMNHRIGLFDMILLKDNHVDFAGG-EQAI----RAQL----N-------EIEVRNFDELEQAMK-GI-R--IMLDNF------------E----N-TKEA---------VRRI--G--VESSGGITFDT-RDY--AECGVDFISVGA-THSVKSLDMSF--A--------------------------- Bathycoccus_prasinos_424513657 --------M-TTA-A-----A------LEEDVANGDVS-LST-PEDLRA-ATLLAKADGVLAGEHLANEI-SI-V-EAFW-K--DGEEIERG-EIFYLRGSARGILRAERVVLNFMQRMSGIATLTKKMSEA-----K-RILETRKTVPGLRVIDKWAVLIGGGENHRMGLFDMVMIKDNHVAAARGI--------NA------TFIEEYEGELETRTMEEVREV-E-GTDTQRVMLDNM------------E----D-MRDA--------MLNKFG----TEASGNVTLET-GGI--GATGVTFISSGQ-THSVVALDISL--I--------------------------- Batrachochytrium_dendrobatidis_328768375 ---P----SHLPTNWK--VS----SW-LDEDTPTFDYGGF--VVGT-DQ-AALYCKAKGVLAGVPFFNQVFSQ-VGCRVEWHVDEGTLID-KV-VARVYGKARHLLLGERPALNMLARASGIATASH-LR-IKDNNWHGVIAATRKTTPGFRIVEKYASLVGGVDTHRMDLSSMIMLKDNHIWATGSITDAV---KKAR-SVGGFALKI---EVECGSEAEATEAILAGADI--IMLDN------FNDGVA---------NLKMFGDSASPQKR-----FLIEGSGG----LTV--DYFSEYVDILSFGA--QSVPHIDFSL--V--------------------------- Bigelowiella_natans_Bigna1_87812 ---------------------------TRKEIQKGEVV-QSA-PEGARG---FLAKADGVLAGLKVAEMV-AS-V-ISWT----DGDYVTRGTYF-NVDGPAESVLTGERLALNLMQRMSGIATQTNCMVEQV---YR-KILDTRKTAPGLRYVDKLACSIGGGTNHRMGLYDMVMIKDNHITSAGGLTNAVSLEKRG-L------------EVETRTLEEVKEAL-CKI-R--VMLDNM--KM---VDTSVD----TTLQQA---------LSLIK-G--TEASGNITLET-KQV--AASGVDYISSGA-THSVMALDISL--V-------------------K------- Botryotinia_fuckeliana_154302740 ---M-A-LEHLPVHWK--IT----AW-FAEDTPSFDYGGF--VVGDSER-ATLYGKSRGILAGVPFFDEVFAQACS--VKWHTKEGTLV--KV-VATVTGPVRKLLLGERVALNTLSRCSGIATKSRDME-LVKAGYKGILAGTRKTTPGFRLVEKYGMIVGGVDGHRHDLSSMTMLKDNHIWARGSITDAV---KAAK-AAGGFALKI---EVEVDSEEGADEAIEAGADI--IMLDN----------SG---------LKVAKSLRQRWGKR-----FLLECSGGLTSENVY-----NN-I--ISTS--HQGVPHVDFSL------------------------------ Brachypodium_distachyon_357159945 --------M---A-L-----SARP--DLSEDAGDGDVS-LAT-PTDVKA-ATFIAKEDGVIAGINLAEMI-NQ-V--KVE-L--DGNYVCKGLQF-KVYGCARSIIVAERVVLNFMQRMSGIATMTKAMADA----RP-CILETRKTAPGLRLVDKWAVLIGGGKNHRLGLFDMVMIKDNHISVAGGITNAMDFLESE--------------EVETRTLEEVKDLL--KT--TRIMLDNM------------PNGDVM-LKDA---------VQLIN-G--TEASGNVTIDT-KKI--GETGVTYISSGA-THSVKALDISLKDQG------------------R------- Branchiostoma_floridae_260820596 ----S--LVHIHPVVK--VR----RW-LEEDTPSFDYGGF--VVGEREQ-AVLLCKSAGVLAGVPFFNAIFEE-LSCTVDWQVPEGTPLEPVSIVAIVTGKVRHLLLGERVALNCITRASGIATQARRMS-IAGTDWHGEVAGTRKTTPGFRLVEKYALLVGGISTHRYDLSSMIMLKDNHIWSAGNITQAV---KDAK-RVGGFCTKI---EVECRSVEEALEAAGAGADV--VMLDN------------PQ-------HPA---------ARV-KFPILVESSGGIRED-LYKF--MGP-VDVISLS--TQGYQTVDFSF-------------KQKNPHNPV-T------ Brevibacillus_laterosporus_550166487 --------W-----------R------LFEDVGHGDIT-MST-PADEKG-GILYAKKSGLIAGLDIAEQVFHT-V--SFQ-F--EGSQVQK-DVI-EVTGSVQAILTGERLALNLLQRLSGIATRTQLFVKEI---TQ-RIVDTRKTTPGLRLLEKYAVRVGGGHNHRFALYDAVMIKDNHSKGAGG-KEAV---RKAR-----HT------EVEAESLMQVQEALEAG--I--IMLDNM-----------CD----L-MREA----------QII--GA-IEASGGVTLE-VRAI--AETGVDVISVGG-THSVAALDISL--N-------------------R------- Canis_lupus_73958447 ---M-----LLPP-LA--AD----SW-LREDCPGLNHAAL--VSGAAPS-AVLWAKSPGVLAGRPFFDAIFAR-VNCQVSWFLPEGSKL-PVAK-AEVRGPAHCLLLGERVALNTLARCSGVASAAAAAV-AAGTGWTGHVAGTRKTTPGFRLVEKFGLLVGGAAAHRYDLGGLVMVKDNHVLAAGGVEKAV---QAAR-QVADFTLKV---EVECSSLQEAVEAAKAGADL--VLLDN------------PE-------HPT---------AAA-KFPVGVEASGGITLANLPQF--CGP-IDVLSLG---QAAPALDFSL------------------------EAPMYR Capitella_teleta_443726530 MQVETT-L-MLHPIVQ--VR----EW-LKEDTPSFDFGGF--VVGEKEE-AVLLCKSPGVIAGAPFFSAVFEE-LNCQVEWLHPEGTFIDPSLQVATITGKVRHLLLGERVALNCITRSSGIASQARRLA-SGDADWHGQVAGTRKTTPGFRMVEKYALLVGGMATHRHDLSSMIMLKDNHIWTAGDIPKAV---SAAK-SVGGFSTKI---EVECRSVEEGKQAASAGADV--VMLDN------------PL-------HKA---------AQQ-KFPIIIESSGGITES-LKDY--MGP-IDIISLS--TQGYDVVDFSF-------------SNHDPANPV-Q------ Chitinophaga_pinensis_256034427 --------M-----------P------LAEDIGNGDHS-LAC-PADARG-ARLKIKEDGILAGMEVAQAV-QM----IFR-F--DGDVMKS--EIAEVDASIHTLLMGERLVLNCMQRMSGIATLTRSYVDVL---YH-RLLDTRKTTPNFRLLEKEAVRIGGGVNHRMGLYDMVMLKDNHIDFAGG-TAAV----KTV-----LP------EVETRNLEDVKEVLAIG--IHRIMLDNF------------P----A-LKEA---------LALI--G--TEASGGINLDT-EAY--AKTGVDYVSAGA-IHHAVSLDLSL--A--------------------------- Chlamydomonas_reinhardtii_159473679 --------M-----------SVHP---LDEDAGDGDVT-LAT-PESTQA-ATFLAKADGVLAGLGVADEV-AI-V-V-KV-W--DGDKVVSG-QV-GVHGSARSILVAERIMLNFMQRMSGIATATAAMVAAL---LP-KVLETRKTAPGLRLTDKWAVLIGGGSNHRMGLYDMMMIKDNHIAAAGGIRAAV----RA------EY-RDEGREVETSTLAEVDEVVELGRHLTRVMLDNM---------ARKE----GSMAEA---------VGRIG-D--TEGSGNVSLNS-RTI--AATGVTFVSVGA-THSVIALDISL--I-------------------T------- Chlorella_variabilis_307110653 --------------------A------LAEDAGDGDIS-LST-PEGTQA-ATFLAKAAGVLAGSWVAHAV-AR-V--HLT-L--DGELVQQGDTI-EACGSARSILVAERVALNFLQRMSGIATMTRQMVD-----TA-SVLDTRKTVPGLRLLDKWAVSIGSGMNHRIGLYDMVMIKDNHIAAAGGIEAAVAEFMRA------RR------EVETRTLDEVREVL-AGSSMTRIMLDNM-----------LD----VSLREA---------VELIG-D--TEASGNVTLDT-RVI--AETGVRFISCGA-THSVTALDISL--I-------------------T------- Chlorobium_luteolum_78186158 ------------------CHG------LEEDRYTGDVT-MAT-PQQ-QG-AVVRAKEDGVIAGVDVAAQV-AA----S---LKLDGERVVQ-ERVFDVHGLLAPILLGERTALNFMQRMSGIATKTRAFVDLV---TE-RILDTRKTAPGLRYFDKEAVRIGGGRNHRFGLFDLILIKDNHIDAAGG-GPAL----RAR-----HGLD----EAEVRSLDELSAALACR--I--ILLDNF------------D----L-MHEA---------VEYV---MPLEASGNMSLYN-KAV--AETGVDFISVGE-THSVRALDLSM--I-------------------L------- Chlorobium_phaeobacteroides_119358065 ------------------QQG------LEEDRYIGDIT-LST-DDNRVG-AEVRAKEDGILAGAEVARQV-AA----AVS-VVCDGDQLMV-DLVLEVSGKLAPLLVGERTALNFMQRMSGIATKTKLFVEKV---TK-SILDTRKTAPGLRYFDKEAVRIGGGRNHRFGLFDMMLIKDNHIDASGG-ANAL----KAR-----HGLA----ETEVRSIDELREALSCK--I--VLLDNF------------D----L-LSDA---------VAFS--EYPLEASGNVGLHN-AQI--AETGVDYISIGE-THSVKALDLSM--I-------------------L------- Chlorobium_tepidum_21674748 --------------------A------LEEDRFQGDIT-EAT-DQNQLG-GYIEVKSEGIIAGVEVARQV-QS----EFT-YV-DGKRVYP-ERVLEVKGRIASILIGERTALNFMQRMSGIATRTNMYVERV---TN-SILDTRKTAPALRYYDKEAVRIGGGTNHRFGLFDMILIKDNHIDAAGS-EEAI----RAK-----EQVS----ETEVRSISELVRACASR--M--ILLDNF------------D----D-LAEA---------VRWIG-GILLEASGNIGLHN-SEV--AMTGVDFISIGE-THSVKALDMSM--I-------------------R------- Chloroherpeton_thalassium_193213974 ------NDF-----------E------LEEDIFTGDIT-DAI-EKSHQS-GIIKVKTDGVIAGIKVAEMI-ER-AGVKFV-Y--DGDIVYAGDVV-EVTASTSLLLRYERTVLNFMQRMSGIATTTRLFVERV---TS-NILDTRKTAPGLRFFDKEAVMLGGGGNHRVGLYDRILIKDNHVDAAGGIGEAI---QRA-Y----HD--V---EVEVRSLEELQEAL-F-P-I--ILLDNF-----------LG----E-LREA---------VHIVG-E--TEASGNVTLET-RSI--AETGVDYISVGA-THSVIAMDISM--I-------------------A------- Chondrus_crispus_546298846 QLSE-G-ILVLPP-LR--AS----SW-LLEDAPSFDGGGF--VVGDVTT-ADIFLKSGAVLAGRAFVDAVFRE-LDCTVTWWAVDGAELDAGARLGSVRGAARKVLLGERVALNALAECCAVATAARAAA-QKAAGWGGRVAGTRKTTPGFRLVQKFGMAAGGMDTHRMDLSGMVMLKDNHVRVAGGVGGAV---RKAR-AVVGFSVKI---DVECARVEEAFEAAAAGADV--VMLDN------------AE-------CEA---------ARA-KFPVLVEGSGGITMETLKGY---VEEADVVSFS---RYVKAVDVSM--V---------------------AK---- Chrysemys_picta_530651528 -----R-L-HLPPPLR--VR----DW-LQEDAPAFDPAGC--AVGEGPE-AVLLCKSPGVLAGCPFFDAVFTE-LGCTVEWFQPEGACLEPVA-VAEVLGKARHLLLGERTALNCLGRCSGVATAAGRAC-LAEAGWHGQVAGTRKTTPGFRLAEKYALLVGGASGHRYDLGSLVMLKDNHVWAAGGIAQAI---QEAQ-RVAGFHLKL---EVECRSLEEALEAAGAGSDI--VMLDN------------PE-------HPA---------ASA-KHPVMVEASGGISEE-ISQF--FGP-IDVLSLG--TQSARAVDFSL---------------RETPVQDA------- Ciona_intestinalis_198427547 KASE---SAYLPQ-VA--IK----SW-LEEDCPSFDYAAL--AVGEKYN-AELLIKSPGIVSGVPFFDAVFQE-VGCEVDWLVSEGMKIDPK-T-ALIRGEARSILIGERVALNCMARCSGISTLAQSFI-KTSLEWNGRIAGTRKTTPGFRLAEKYALVVAGADTHRYNLSSMVMLKDNHISSSGNVSSAV---ERVK-FAAGFSVKV---EVECQSLEEAIEAVESGAEI--IMFDN------------SE-------HIA---------AAA-KFPVIIEASGGITEDNLASY--CGP-VDVISSS---QGYSVVDYSL------------------------E----- Coccomyxa_subellipsoidea_545355350 --------------------GHAP---LEEDAGIGDVT-LST-PADTQA-ASFLAKADGILAGLAVADKV-AA-V--EVT-T--DGDFVVKGTIF-GVRGAARSILVAERVALNFLQRMSGIATAARAMVA-----HA-RILETRKTVPGLRLLDKWAVLIGGGVNHRIGLYDMVMIKNNHISAAGSVNAAV----RTLT----RG-R----EVEARTLQEVHEVL-AG-DR---MLDNM----------TVQ----M-LQSA---------MDLVK-G--TEASGNVSIET-RRI--ASTGVGFISCGA-THSVTALDISL--I-------------------D------- Cohnella_laeviribosi_517835836 --------F-----------F---S-QLAEDIGSGDVT-MAT-PEGHRS-GIIHAKASGIAAGMPLARLVFET-V--KFE-R--DGTRLEK-TVL-VVEGSTHSILTGERLALNLLQRLSGIATQTRIYVDAA---YP-RIADTRKTTPGHRTLEKYAVRVGGGYNHRYGLYDAVLIKDNHIKAAGG-AEAV---RAAK-----HT------EVEAESLAQAEEAVRSG--I--VMLDNM-----------TE----R-LREA----------ARV--EAPLEASGGVRPE-VREL--AASGVDIISVGS-THSFQALDISL--E-------------------K------- Colletotrichum_graminicola_310797743 ---P-L--EHLPPSWK--VT----AW-LAEDTPTFDYGGF--VVGNDAR-ATLWGKSGGIIAGRPFVDEVFAQ-CGCAVEWHVKEGSHV-GKM-VATVTGPARGILLGERVALNTLARCSGVASMTRMLV-LRAAGYAGVLAGTRKTTPGFRLVEKYGMLVGGADAHRMDLSSMIMLKDNHVWSKGSITNAV---KAAK-SVGGFSLKV---EVEVQTEDEADEAIAAGADV--VMLDN----------TG---------VKVAKSLKTKWGKK-----FLVEVSGGLTLENVY-----CN-VDILSTS--HQGVPHVDFSL------------------------------ Crassostrea_gigas_405970213 --------------MA--------EW-LKEDTPNFDYGGF--VVGEKEE-ALLLIKSPGVLAGKPFFEAIFKE-LDCVVSWEYDEGEFLEPIQ-VAKVTGKVRQLLLGERVALNCLSRASGIASLARQLA-IKRVGWKGEIAGTRKTTPGFRLVEKYALMVGSVSTHRHDLSSMIMLKDNHIWTSGSITQAV---KDAK-IVGGFSLKV---EVECRSVDEALEAAEAGSDI--IMLDN------------SE-----FRNPA------LPAATK-KYPVLIEASGGITEA-IEKY--LIP-VDVVSLS--TQGYDVVDFSL-------------KAVDPRNLV-------- Cryptococcus_neoformans_58264948 ET-P-G-QNHLPPSWS--VQ----RW-FAEDTPSFDWAGF--VVGEEEQ-AILWGKSGGVLAGVPFFEEVFKQ-VDCAVEWLMPEGSVV---T-VAIVRGKARQLLLGERVALNTLARCSGIATVSRRFR-LAAEGWKGVVAGTRKTTPGFRLVEKYGMMVGGVDPHRHDLSSMVMLKDNHIWATGSITSAI---QTVR-RVAGFSLLV---NVECQNFKEADEAVTAGANI--VMLDN----------VG---------LHSARRLKEKWGQR-----FLIETSGGI-IESLR-----GP-IDILSTS--HQSCPHVDFSL------------------------RS---- Cyanidioschyzon_merolae_544214606 ---E-------PPLLN--IE----RW-LLEDAPSFDFSSL--VDL-RPA-GTLWQKSAGVVAGRPFFDAVFET-LGCSVTWELEEGSSSAR-A----VRGPARRLLQGERTALNLLSRCSGVATRARQFK-LCVRQWHGVIAGTRKTTPGFRLVEKYGMHIGGADMHRVDLSGMIMLKDNHLACIGVIQEAV---RRAR-NCAGFSVSV---EVECGSEASALAAITAGADV--IMLDN------------PE-------CET---------AKR-R--TAIEASGGITLETAPRY-MCAA-ADIISVS---QGYECVDYSL------------------------STREA- Cyanothece_sp_495549546 --------M-----------S------LQEDIGRGDRTGLNC--QE--G-GQWIAKAEGIIAGLPIAQRV-EL-L--QFI-V--EGERVKTGQVIAKLNGPLNLLLTGERVALNLSMRLSGIATMTRQYTEVI---LP-QLVDTRKTTPGLRILEKYAIQVGGAKNHRMGLDDGVMIKDNHIKAVGSQG-AI----KT--QTIPYP------EVETTTFKEVEEALNYGA-I--IMLDNM------------E----L-MKEC----------KYIN-K--IEASGNITLDN-RQV--ALTGVDYISSSAPTRSIW-LDLSM--L--------------------------- Debaryomyces_hansenii_294659145 ---S-S-YANLPANWK--IT----DY-LQEDVPSFDFGAF--VVGNKQE-ASLYMKQAGLISGVPFTAEVFKQ-CELEVEWLHKEGEFITEKI-VAVVKGPANKILLAERTALNLLARSSGIATQSRLTKNLAESGYTGLIAGTRKTTPGLRQLEKYSMLIGGVDTHRYDLSSMVMLKDNHITSTGSITKAV---KSAR-SVCGFAVKV---EVEVSTEEDAREAIDAGADV--IMLDN--------EGLQ---------AQ--SLKKFYEKSK-----FLLECSGGLTLSNLY----LCN-IDIYSTS--HQGCGIVDFSL-------------------------D---- Desulfotomaculum_ruminis_334338847 --------M-----------L------LAEDIGTGDIT-NST-PIGSRA-GMIYVKEPGVLAGLAVAEEV-RQ-M--HFH-R--DGTWVEP-TVV-EVEGDARAILTGERLALNFLQRMSGIATRTAALVEKV---YP-RVVDTRKTTPGLRMLEKYAVRVGGGFNHRYGLYDAVLIKDNHIKVAGG-TQAV---LAAR-----HT------EVEVEDLAGVSEALEAR--I--IMLDNM-----------QA----T-MREA----------KLV--GA-VEASGGINEE-IVAA--AKAGVDLVSIGA-THSIKSLDISL--K-------------------H-K----- Dictyostelium_discoideum_74876284 ---E-I-SQ-L---FK--IK----EW-LEEDIPSFDYGGC--VVGSDEK-AHLLGKQNGVFSGSIFFQEIFNQLC--KVIWFIKDGEFS-PQ--LAHVIGPVRNILIGERLSLNILSRSCGITTQGYNVK-LVQQPWKGKIAGTRKTTPGFRLVEKLALLTAGLDTHRMDLSSMIMLKDNHIW-CGNITNTV---KNAR-SVGGFSLKI---EVECRNQNEAIEAIEAGADI--VMLDNFNPLQVSTLKYP----------------------------ITLEASGGITSATIY----AIP-IDIISMGN-TQGVPHIDISL------------------------------ Dictyostelium_fasciculatum_470247366 NN-S-S-LSYI-KSIQ--VR----AW-LKEDIPSFDYGGA--VVG-DKK-AYLLGKQPGVFSGTVFFNEIFIM-LDCEVKWIIKDGEEM--QR--AEVTGSVRNILMGERLALNIISRSSGITTASEKLV--A---WKGTLAGTRKTTPGFRLVEKYALLVGGVDGHRMDLSSMIMLKDNHIW-SGNITNAV---HSAK-SVGGFSIKV---EVECRSEDEACEAMEAGADV--IMLDNMVPLAVSLLKYP----------------------------IVIEASGGIVLTR-Y----ALP-IDIISMGS-TQSVPHIDISL------------------------------ Dictyostelium_purpureum_330845892 ---E-L-SL-I-NNIE--IK----EW-LEEDIPSFDYGGV--IVGSDIK-AHLLGKQTGVFSGKVFFDEIFRQLC--SVKWFIKDGEFT--QL--AIVEGPCRNILIGERLSLNILSRSCAVTTQASAIK-LVNVDWKGKVAGTRKTTPGFRLVEKLALLVAGLDTHRMDLSSMIMLKDNHIW-CGNITQAV---KNAH-SVGGFSLKI---EVECRNQDEAIEAIEAGADI--VMLDNFNPLNVSTLKYP----------------------------IKIEASGGITVQTIY----AIS-IDIISMGN-TQGVPHIDISL------------------------------ Ectocarpus_siliculosus_298708640 ---P-D-YED-PRNWE--VQ----TW-LDEDIPGFDVGGY--VVGS--KEAILYGKTDGVLAGRPFFDRVFTLLC---VDWLMSDGAQINTKV--AKVTGSCRHILQGERTALNVISRCSGVATATFEAV-QAAKGWKGYVAGTRKTTPGFRLVEKYALVVGGGATHRYDLSQMVMLKDNHIASAGGITRAV---EVAR-RAAGFSMKI---EVETSNYGQAAEAARAGADI--IMLDN------------PE-------KSV---------SRR-KFPVILEASGGITAEHLFL----EDSVDVISQG----GYNCLDFSL--I--------------------------- Flavobacterium_johnsoniae_146301230 --------------------A------IREDVGPGDYS-LAC-PDTAHG-AKLLVKDQGIIAGVELAKMI-EH----KVK-F--DGTHVEY--EVVEVSGSSQSILKAERVVLNTMQRMSAIATKTNHLMGLL---TN-KILDTRKTTPNFRVAEKWAVKIGGGENHRYALYDMIMLKDNHIDFAGG-TRAI----KAK-----EY--ENLDIVEARNLDEIREILLSG--R--ILIDNF------------E----D-TKTA---------VNLI--S--TESSGNIS-EKVREY--ALCGVNYISSGA-THSVYNMDLSL--A--------------------------- Fusarium_graminearum_46136067 ---P-K--ENLPPSWK--VT----AW-LAEDTPSFDYAGF--VVGDGPR-ATLWGKSSGVIAGRPFFDEVFVQ-CGCTVEWHAEEGNDV---H-VATVKGPVRGILLGERVALNTLARCSGVATKSSRLV-IAKAGYTGVIAGTRKTTPGFRLVEKYGMLVGGADAHRMDLSAMIMLKDNHVWSRGSITDAV---KAAK-SVGGFSMKV---EVEVQSEAEADEAIEAGADV--VMLDN----------TG---------VKVSRSLKERWGKR-----FLLEVSGGLQEDNFY-----CN-VDILSTS--HQGVPHIDFSL------------------------------ Galdieria_sulphuraria_545706519 ---T-Q-HSHIPQHI---VL----SW-LEEDIPSFDWGAQ--AVGDRIT-ATLYIKSKGLLAGKPFFDAIFQQ-LDCTVHWYIDDGQWFD-ML-IARIQGPACQILRGERTALNVLARCSGIATRAFQLT-LAQHNWQGCISGTRKTTPGFRLVEKYAMLVGGVDTHRMDLSSMVMLKDNHIWSCGSIAQAI---QQVQ-RVAGFSLKV---EVECQSFSDACQAAEKGADI--VMLDNMNPAKVANLRYP----------------------------VLIECSGGIREDNVYF----SS-IDILSLSS--S--------------------------------------- Geitlerinema_sp_516256703 ------RAW-----------S------LKEDIGRGDAT-QLL-GTD-RG-AIWTAKAEGIVAGLPLARRI-KLGS--S---L--DGTACAPQTAIARFEGPLDALLMGERTALNLVMRLSGIASTTRQYVETI---LP-QLTDTRKTTPGLRVFEKYATRIGGATNHRMGLDDAVMVKDNHIAAAGGIQAAI----RI--PQIPYP------EVETETLDQVREALEGGA-I--IMLDNM------------E----Q-MREA----------VLIR-G--IEASGNITLDR-RSV--AETGVDYISTSAPTRS-HWLDISM--S-------------------A------- Geminocystis_herdmanii_515863331 --------M-------IT--S------LLEDIGRGDRT-DCI-PVDPQG-AYWIAKEEGVIAGLPIAKRV-QL-L--KWH-L--DGETLTINSKIMDIEGKMKTLLTGERLALNLVMRLSGIATMAKKYVEAI---YP-KLVDTRKTTPGLRILEKYASQVGGAMNHRMGLDDGIMIKDNHIQASGS-GKAI----LI--KTMPYP------EVETSNLEEVTEAINHQA-I--IMLDNM------------A----E-MTKA--------LIRQEN-P--IEASGNVTLTN-RHI--AETGVDYISTSATTRSSW-LDISM--F--------------------------- Gloeocapsa_sp_434395003 --------M-----------N------LIEDIGRGDRT-QLL-AEN-WV-AQWIAKAPGVIAGLPVAARV-QL-L--RFI-T--EG-QLCQGQVVAQIEGPLEALLTGERVALNLVMRLSGIASLTRKYVEKL---LP-RLVDTRKTTPGLRLLEKYATQVGGAKNHRMGLDDAVMIKDNHIAAAGG-GNAI----RI--AQISYP------EVETETIEQVQEALQHQA-I--IMLDNM------------E----V-MYQA--------LIRQYN-K--IEASGNITLDT-YQV--AATGVDYVSTSAPTQSSW-LDLSM--I-------------------G------- Halarchaeum_acidiphilum_545903776 --------------MT--AE----RW-LREDLGHDDVTN------DLPGSARLVAKEPGVVAGLDAADVVFDV-LGVSVETRVEPGERIDAGD-LLAVEGPTRDVLRGERVATNLVGHASGIAART-EAVDAAS--ES-EIAATRKTTPGLRGVEKRAVRAGGGDTHR---LDAVMVKDNHV--AFGLEDAI---ARFR-ERASFATRI---DVEVESVAEAERAADAGADV--VLVDN-------------G-------GEA---------R-R-D--VIVEASGGIGV-DVP-Y--AAA-ADVVSMGA--HSGAPLDCSF----------------------E------- Halococcus_morrhuae_490156868 ----------M----R--IE----RW-LREDL--S-HHD---VTN-VPG-TALVVTEDGVAAGIETAAAVFDH-LGVETETLVDTGERVEAGQ-VLAVDGPAREILRGERVAVNVAGHASGIATRT-AAVDAAEDGANGRIAGTRKTTPGLRGIEKRAIVAGGGDTHRLDCSQMVMVKENHI--EMGFESAI---AHFR-ERASFATKI---EVEVERPADGRRAADAGADI--VLFDN------------PD-------------------A-G--LPLA-EASGGITI-TVP-Y--AAT-VDVISLGS--HSAPALDYSF------------------------------ Haloquadratum_sp_544619543 -----------M-SRN--LP----AW-LKEDIGPHDVTNA--VPG-TAG-LV--SKESGVVAGLSAATRVFEY-LDVDSTATVEDGDQVTPGE-VLRVTGEAQPILRGERVAVNITGHASGVATLT-AVEEAHV--DE-QIAATRKTTPGLRGIEKRAVVAGGGDTHRLTLSHMVLIKENHI--EMGLETAI---EQFR-EQVSFTTKI---EVEVERPQTGRKAAQAGADV--VLFDN------------AE-------KRG---------V-H-P--TTAEASGGIRL-VAD-A--A-T-VDIISMGA--HSAPTLDFSF------------------------------ Halorubrum_coriense_493053117 --------------TD--VE----RW-LREDV-GH-HD----VTN-VPG-TTLVAKESGVAAGVDAASAVFDY-LDATVTERLADGT-VAPGD-LLRVRGPATAVLRGERVAVNVAAHASGVATAT-AAVAAAE-----EVAATRKTTPGLRGVEKRAVAAAGGDTHRLDLSHMVMVKDNHV--EMGLTGAI---ERFR-ERASFALDV---EVEAPG--DAARAAEAGSDV--VLLDN------------PA-------T-----------A-A-DDAALTEASGGITV-TVP-Y--AAT-VDVISMGG--HSAPALDLSF------------------------------ Halorubrum_sp_544625340 ----------IT------IE----RL-LKEDI-GH-HD----VNN-VPG-TTLVAKESGVAAG---VDAVFEY-LDCETAV--QVGSGSVDAG-IVETDGKAKSVLRAERTGVNIAGHASGVATRT-MAVDRAT--ET-RVAGTRKTTPGLRGLEKRAIVAGGGDTHRLDLSHMVLIKDNHI--EMGMETAI---ERFR-EKASFATKI---EVEVET-PEASRAAEAGADI--VLFDN------------PK-------EQG---------L-S-P-ETLAEASGDITL-DIP-Y--AET-VDIISMGS--HSADTLDYSF------------------------------ Halosarcina_pallida_495660202 ----------LT------VE----RW-LREDV-G--HRDV--TNDPGET-GRLVAKEAGVAAGVAAALAVFDY-LGVEASPLVDAGE-VEPGA-VLEASGPAREVLRGERVAVNALAHASGVATRT-RAVDAAA--PS-RVAATRKTTPGLRGVEKRAVAAGGGDTHRLTLSGTVMVKDNHV--EMGLETAV---ERFR-ERKSFATKL---EVEVES-PEAARAAAAGADI--VLFDN------------PG-------R-----------A-V--LPGALEASGEITL-TVA-Y--AAT-VDAVSMGS--HGAPSLDLSF----------------------D------- Heliobacillus_mobilis_27262196 --------F-----------P------LREDIGNGDLT-MNL-PADAYT-GIIHAKEAGVIAGLPIAQRV-ET-V--RFE-M--EGDKVEK-TVI-EVFGSARSVLIGERVALNFLQRLSGIATKTARCVEQV---YQ-RIVDTRKTTPGLRAVEKYAVRIGGGKNHRFGLFDGVLIKDNHIKMAGS-TQAV---SQAR-----HT------EVEVEDLAGVAEALEAK--I--IMLDNM-----------PD----V-MKEA----------RMI--GA-VEASGGVSEE-LVEI--AKTGVHLISMGS-THSIKSLDISL--V---------E---------K------- Helobdella_robusta_555695892 ----M--LKHLHPTLR--VN----YW-LEEDTSNFDYGGF--VVGEKIE-AYLLGKCEGILAGSPFFEEVFRS-LDCSVDWHISEGSLLKPVV-VATVTGKVRNVLLGERVALNCLARSSGVATYAKKLN-VVGMPWHGEIAGTRKTTPGFRLVEKYALLVGGISTHRYDLSSMIMLKDNHIWSAGSITNVI---KDAR-SVGGFNSKI---EVECRSLEEALEAAEARCDI--IMLDN------------LE-------HKT---------ASI-KFQILIEASGGVNED-ILDY--VGK-IDVISLS--TQGYNILDFSL-------------KF--------------- Homo_sapiens_119600420 QPQM-----LLPP-LA--VD----SW-LREDCPGLNYAAL--VSGAGPS-AALWAKSPGVLAGQPFFDAIFTQ-LNCQVSWFLPEGSKL-PVAR-AEVRGPAHCLLLGERVALNTLARCSGIASAAAAAV-AAGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAV---RAAR-QAADFALKV---EVECSSLQEAVQAAEAGADL--VLLDN------------PE-------HPT---------ATV-KFPVAVEASGGITLDNLPQF--CGP-IDVISMG---QAAPALDFSL------------------------KVPVPI Komagataella_pastoris_254572087 MS-P-E-FAHLPVDWK--IT----SW-LDEDTPSFDYGGY--VVGENLQ-ATLWIKSNGVISGVPFAQEVYKQ-CGLEVEWFLKEGDYI--KV-VALVKGPVRNILLAERLSLNILARCSGVATQSYITIKRAEAGYKGIIAGTRKTTPGLRLLEKYSMLVGGCDSHRYDLSSMIMLKDNHIWSTGSITKAI---ESAQ-KVIGFSTKI---EVEVQDEAEANEAIAAGADI--IMLDN--------TGLK---------AI--NLKNKWATNK-----FYLECSGGLTLDNIY----LCN-IDIYSTS--HQGVGIVDFSL------------------------------ Kyrpidia_tusciae_295694784 --------------------M------LREDIGYGDVT-RHV-PAGARA-GTFRAKSSGVIAGLPVAREVFEV-L--TFQ-L--EGESVGP-QAV-VVEGRASSILTGERVALNFLQRLSGIATKTAKFVESV---YH-RITDTRKTTPGLRALEKYAVRVGGGYNHRFGLFDAVLIKDNHIAVAGG-KQAI---MAVR-----HT------EVEVETFEQIDEALEVK--I--IMLDNM-----------VE----Q-MKEA----------ERI--GA-VEASGGVTEE-VVDI--AKTGVDYISVGA-THSSTALDISL-LV-------------------E-S----- Laccaria_bicolor_170090746 ---K-S-FEHLPPSWK--VT----AW-LTEDTPSFDYGGY--VVGEVER-AFLLGKKNAVLAGSPFVTEIFAQLCT--VEWHVQEGDIF--RH-IATVNGKARFLLLGERIALNLLARCSGIATQSKKIR-LASYGYKGIIAGTRKTTPGFRLVEKYGMLVGGIDPHRHDLSSMIMLKDNHIWSSGSITAAI---QQAR-SVGGFSLLL---DVEVGSEAEADEAIEAGADI--IMLDN----------EG---------LVNASSLKAKWGQR-----FLFETSGNITEANLR-----IN-IDILSTS--HQSVQHIDFSL------------------------PE---- Latimeria_chalumnae_557006856 -------L-HLHPVLK--AQ----DW-LLEDTPAFDYGGF--VVGEQEE-AYLLCKSPGVLAGAPFFDAIFRE-LDCQVEWFHPEGASLEPVC-VAAVKGKVRHLLLGERVALNCLARASGVATAARRIA-LAAAKWHGEVAGTRKTTPGFRLVEKYAMLVGGAATHRYDLSSMIMLKDNHIWSLGNISTAV---REAR-RAGGFSTKI---EVECRCLEEALEAAQSEADV--VMLDN------------PQ-------HTT---------AQA-KFPVLIEASGGISEE-VTQY--LGP-VDVVSLG--TQVFRVVDFSL-------------RDGNSAAHG-SSSTTPQ Leptolyngbya_sp_427724983 ------HLP--------A---------LQEDLGRGDRTALFT-PT---G-AQLILKAPGIVAGLPFVERV-QL-I--EMQ-A--EGK---DKTLIATLTAPLDTLLMGERVALNILMRLSGIATETAHYIEDL---T---LVDTRKTTPGLRLLEKYAVRVGGGRNHRYGLDDAMMIKDNHIQAAGG-TEAI----AV--ANSPYP------EVEAETLEQAIEAVQQGA-I--VMLDNM------------K------MAEV--------PLREIN-P--LEASGNITLET-RAV--AETGIDFISTSATTR-APWLDISM--I-------------------A------- Lottia_gigantea_556108132 -----ANL-CLSPILR--AR----EW-LKEDTPNFDYGGF--VVGEKPE-SVILLKSAGVLAGVPFVNAIFKE-LDLEVEWFFKEGQRLEPIQ-VAAVTGKVRQLLLAERIVLNVLTRASGIASLARELN-IASCRWDGEVAGTRKTTPGFRLVEKYALLAGGATTHRYDLSSMIMLKDNHIWTAGSITQAV---KDAK-IVGGFSHKI---EVECRSLDEAQEAGTAGADV--IMLDN------------PE-------IST---------STE-KFPVVIEASGGITKL-MADY--CVP-VDVVSLG--TQGYSVVDFSM-------------KDKDPRNLV-------- Marivirga_tractuosa_313676446 --------------------E------LAEDIREGDHS-LAS-PAGTQN-AQLIIKGDGILAGMEMAEHI-KA----EID-F--DGDKVTS--EIGKVHGSAVSILSAERLVLNCLQRMSGIATYTHNLNELI---TS-KLLDTRKTTPNFRIAEKWAVAIGGGQNHRFGLFDMVMLKDNHNDFAGG-TKAV----STQ-----EY--QNLDEVETRNLDEVKEALAVGV-V--IMLDNM------------P----E-MKQA---------VEII--G--TEASGGITEDT-KAI--AETGVDYISVGA-THSYKSLDMSL--A-------------------S------- Medicago_truncatula_217072004 -------MY---QGLQIS--SLHP---LAEDAGDGDIT-LAT-PFDMEV-AYFLAKEDGIVAGIALAEMI-NE-V--EWS----DGDFVHKGLQF-KVHGRAHNIVVAERVVLNFMQRMSGIATLTKAM-AN----SP-YILETRKTAPCLRLLDKWAVLIGGGRNHRMGLFDMVMIKDNHISTAGGVTNAL------------LY--KSLQEVETRTLEEVEEVL--KT--TRIMLDNM------------SNGDIM-LKEA---------VRLVN-G--TEASGNVTIDT-HKI--GQSGVTYISSGS-THSVKALDISLKDKG------------------C------- Meyerozyma_guilliermondii_190346853 ---M-S-YSNLPANWK--IT----EY-IREDVPSFDFGAF--VVGDKPE-AKLFMKQKGVICGVPFAAEVFKQ-CELEVEWHFKEGDYVSQKI-VATVHGPANNILLAERTALNLMARASGIATQSH--ITLAKSGYTGIIAGTRKTTPGLRQLEKYSMLVGGIDTHRYDLSSMVMLKDNHITSTGNITEAV---KKAK-SVCGFAVKV---EVEVSSEKDAIEAIDAGADV--IMLDN--------QGLQ---------AK--SLKSRYQSNK-----FLLECSGGLTLSNLY----LCN-VDIYSTS--HQGTGIVDFSL------------------------------ Microcystis_aeruginosa_488885608 --------M-----------P------LREDLGRGDRT-QAI-FGH-KG-ATWIAKEAGVIAGLPVAERV-QL-L--HFT-T--EGEFCPKSKVIAEIEGSLDALLIGERVALNLAMRLSGIASATRQYVEKI---LS-RLVDTRKTTPGLRILEKYASGIGGAINHRLGLDDAIMIKDNHIQAAGS-EEAV----RV--QNMPYP------EVETSQLEEVNQALQQQV-I--IMLDNM------------E----M-MQTA--------MIRNFN-S--IEASGNITLDR-RNV--AETGVDYISTSAPTRSTW-LDISM--I--------------------------- Micromonas_pusilla_303271165 --------M---A-L-----APHH---LEEDVADGDIS-LST-PVETVS-ATLLAKADGVLAGQHLAVMI-RA-V--RFA-V--DGDTIERG-EIFEMRGKAHSILRAERVVLNFMQRMSGIATLTKKMADAA----P-FMLETRKTVPGLRLPDKWAVLIGGGKNHRMGLFDMIMIKDNHIAASGGIKSAV----NA--------------EVETRTLEEVDQILF-SASR--VMLDNM------------E----D-MTTA---------VKKIA-G--TEASGNVTLDT-HAI--GQTGVTFISSGA-THSVMALDISL--I--------------------------- Micromonas_sp_255080870 --------M---P-M-----APAH---LEEDIADGDIS-LST-PEATVS-ATLLAKADGVLAGQALCNQI-AA-V--SWS-L--DGDVIGKG-DIFEMTGKAHSILRAERVLLNFMQRMSGIATLTKAMADAA----P-YMLETRKTVPGLRLPDKWAVLIGGGKNHRMGLFDMIMIKDNHIAASGGIDKAV----NAQL----DG------EVETRTMDEVDEAV--SASR--VMLDNM------------D----D-MREA---------VALIG-G--TEASGNVTLET-HAI--GQTGVTFISSGA-THSVVACDISL--I--------------------------- Mixia_osmundae_358057313 ---P-A-LAHLPPSWR--IT----SW-LAEDTPSFDYGGF--VVGESEE-AILYGKSEGMLAGRPFFDEVFAQLCTVQ--WRLDEGTYF--KV-VARVRGKARHILLGERVALNTLARCSGIATKSFRLA-QARAGWKGIIAGTRKTTPGFRLVEKYGMIVGGIDAHRYDLSSMVMLKDNHIWSKGSIPDAI---AAAR-SVCGFSLRI---DVECTSEQEAIQAIEAGADV--IMLDN---TP---QLSS---------LKEYSARHADGHTR-----FLIEMSGGITEDNLH-----LP-VDIISTS--HQSVSHVDFSL-----------------------------P Monodelphis_domestica_126334616 ---L-----RLPP-LE--AD----SW-LREDCPGFDYGAQ--VAGAAPF-AELWAKSPGVLAGRPFFDAVFSR-LDCQVTWFLHEGSHL-PVAR-AEVRGPAHRLLLGERVALNALARCSGVASAAAAAV-TAAAGWKGHVAGTRKTTPGFRLAEKYGLLVGGAAAHRYDLGGLVMVKDNHITAAGGVEKAV---QRAH-KAGDFALKL---EVECSSLQEALKAAQAGADL--VMLDN------------PE-------HPT---------AAA-KFPVGVEASGGITLQNLPQF--CGP-IDVISLG---QAASVVDFSL------------------------KGQKPD Mortierella_verticillata_MVEG_07206.1 ---A----NHLPLNWK--IT----EW-LQEDIPSFDYGGY--VVGE--KTAILFGKSEGVVAGVPFFTEIFEQ-LGCRVEWHVKEGEVLK----CAHVYGPVRQILIGERTALNLIARCSGIASQAHRLR-LKKNGFKGLVAGTRKTTPGFRLVEKYGMLVGGADTHRMDLSSMIMLKDNHVWSTGSITAAV---EKAK-AVGGFALKI---EVECRSEDEADEAIAAGADI--VMLDN----------GD---------KVAANIKQRWAKGR-----VLVECSGG----VTI--QYFCDSIDIISLGS--QGVSFVDFSL--V--------------------------- Mucor_circinelloides_511011227 ---A----AHLATNYK--IA----DY-LAEDVPSFDYGGY--VVGEDDQ-AILYCKAEGVVAGVPFFDEVFKQ-LDCRVEWTCKEGDWLK-KQ-IARVYGCARNILLGERTALNIISRCSGIALRARMVS-LQAKGFKGVIAATRKTTPGFRLVEKYGVLVGGLDTHRMDLSSMVMLKDNHIWSSGSITKAV---QNAR-SVCGFALKI---EVECQSEEEADEAIAAGADI--VMLDN---------FEG---------AAASIKERWAAGKN-----FLIESSGG----I-Y-----CEDIDVLSMST-TQGVPHVDFSL--I--------------------------- Mus_musculus_19526852 ---M-----LLPP-LA--AN----SW-LQEDCPGLNFASL--VTGSAPS-AVLWAKSPGVLAGRPFFDAIFTQ-LNCQVSWFLPEGSKL-PVVK-AEVKGPAHHLLLGERVALNTLARCSGIASAAATAV-VASTGWTGHVAGTRKTTPGFRLVEKYGLQVGGAACHRYDLGGMVMVKDNHVVAAGSMERAV---LKAR-QAAGFSLKV---EVECSSLEEAFRAAEAGADL--VMLDN------------PE-------HPT---------AAT-KFPVSVEASGGVTLDNLTQF--CGT-IDVISLG---QAAPALDFSL------------------------EDPVPR Nannochloropsis_gaditana_422293510 ---Q-G-IAQ-PPVRA--------GW-LEEDVPSMDIGGF--VVGETPT-ALLYGKSKGILCGKVFFDAVFK--L-CTVEWMMEDGAVLSPKV--ATVKGKARHILLGERTALNILTRASGIATISRASV-IGRAGWHGTIAGTRKTTPGFRMVEKYALLIGGAATHRQDLSQMVMLKDNHVWSTGSITKAV---KAAR-GVGSFSIKI---EVECQTLSQAQEAGAAGADV--IMLDN------------PP-------KET---------AAL-KYPVVIEASGGITTETLEEY---SPHVDVISRG---QGYPALDFSL--I--------------------------- Natronomonas_moolapensis_452207189 ----------IP------IE----AW-LREDL--G-HHDV--TNDPGET-GRLVATERGVAAG---IEAVFEY-LGVESSTAVGAGDR-VDAG-VVRTEGPARETLRGERVAVNVAAHASGIATRT-TALEAAR-SED-AVAGTRKTTPGLRGVEKRAVAAGGGDTHRLDCSHMVMIKDNHV--ELGIERAV---ERFR-ERASFATRI---EVEAETEAEALAAAEAGADV--VLLDN------------PA-------AAT---------V-V----VVTEASGGITI-SLP-Y--AAT-VDVVSLGS--HSADALDLSF----------------------E------- Nematostella_vectensis_156373006 -----N-F-LIPKVIE--VE----TW-LKEDTPSFDYGGF--VVGSSVE-AVLLCKSDGVLAGVPFFNAIFEK-LDCKVEWQNNEGDPIKAVS-IGTVTGPVNKILLGERVALNCISRASGIATKSRSLT-LKQYQWHGEIAGTRKTTPGFRVVEKYALEVGGVSTHRYDLSTMIMLKDNHIWSTGNITRAV---KNAR-RVGGFSMKI---EVECRSLEEALEAAHAGAEI--VMLDN------------PQ-------HTT---------AKT-KCAVIIEASGGIN-DSIAQY--FGP-VDVISLG--TQGKP-VNFSL------------------------------ Neurospora_crassa_16945374 ---M-I-LEHLPVSWK--IT----AW-LAEDTPSFDVGGF--VVG-DAR-ATLWGKSQGILAGVPFFNEVFKQ-CGCTVEWHATEGCHV--KR-LATVTGPARGLLEGERVALNILARCSGVATQSRLLV-LRSAGYKGIVAGTRKTTPGFRLVEKYGMLVGGADTHRMDLSTMTMLKDNHVWSRGSITEAV---KAAK-AAGGFSLKI---EVEVQSEEEADEAIAAGADI--IMLDN----------TG---------VRVARSLKERWGKK-----FLLEVSGGLTADNAY-----CH-IDILSTS--HQGVPHVDFSL------------------------EGGPE- Nodosilinea_nodulosa_515868781 --------M-------SI--G------LHEDVGRGDWT--LV-----PG-ALWVTRAPGVIAGLPMARRL-QR----SFE-L--DGEPCGADTTIAKISGTLAALLTGERVALNLVMRLSGIATATRQYVEQL---SP-QLVDTRKTTPGLRQFEKYASRVGGAVNHRLGLDDAVMIKDNHIAAAGGIRAAV----QI--PAIPYP------EVETTSLEEVDEAIACPV-V--IMLDNM------------E----M-MKLA----------ARIR-E--IEASGNITLET-GAM--AATGVDFISTSAPTRA-PWLDISM--I-------------------S------- Oreochromis_niloticus_542187933 -----H---VVPHHLT--AR----AW-LAEDTPNFDPAGV--CVGSREV-ARLLCKTPSILAGCPFFTAVFTE-VGCTVDWIYQEGAEIGEVT-TAVVRGPANSLLLGERPALNCLARASGIATRCSQLQ-IAAHGWHGEVAGTRKTTPGFRLVEKYAMLVGGVSMHRQDLSGMVMLKDNHVWASGSISEAV---KAAR-SVCGFSSKI---EVECRSAEEGREAARAGADV--VMLDN------------PQ-------RVT---------AQA-KFPLLIEASGGVTPE-VALY--LSS-VDVVSLG--TQGCPVVDFSL---VQKPDGRLNR---------N------- Oryza_sativa_115480575 --------M---ARL-----S-LP--DLSEDAGDGDVS-LAT-PSDVKA-ATFIAKEDGVVAGISLADMI-KQ-V--KVE-F--DGNYVHKGLQF-RVYGCARNIIVAERVVLNFMQRMSGIATMTKAMADA----HP-CILETRKTAPGLRLVDKWAVLIGGGKNHRIGLFDMVMIKDNHISVAGGITNAMDFL--A--------------EVETRTLQEVKDLL------TRIMLDNM------------GNGDVM-LKDA---------VELIN-G--TEASGNVTIDT-KKI--GETGVTYISSGA-THSVKALDISLKDQG------------------R------- Ostreococcus_tauri_308802007 --------M-----------V------LSEDAGDGDVS-LST-PSTTTS-ATLLAKATGTLAGESLANRV-DA-V--EVE-M--DGETIEAG-EVFRIKGSARSILRAERVVLNFMQRMSGIATMTRAYADAA----P-VMLETRKTVPGLRVIDKWAVLIGGGKNHRIGLFDMVMIKDNHIAAAGGIAKAV----AC-------Y--NLSEEVEARTMEEVDTVI--DPNVTRLMLDNM------------Q----D-MTEA---------VRRIA-G--TEASGNVTLDT-PAI--GKTGVTYISSGA-THSVKALDISL--I--------------------------- Paenibacillus_dendritiformis_493728944 ------------------------R-QLQEDIGTGDVT-AYT-PAGHQS-GIIHAKEDGMIAGLPVAEAVFEI-V--RFT-Q--DGAVVAR-TVL-EVEGSTHSILCGERLALNLLQRLSGIATKTNKFVQAI---LN-KLVDTRKTTPGHRALEKYAVRVGGGSNHRFGLYDAVMIKDNHIKGAGG-EAAV---SRAR-----YT------EVEAESIEQVKEALQAG--I--IMLDNM-----------TA----R-MREA--------LIREA--PI-IEASGGVTLDTDKAL----TGVDVVSVGA-TYSFHALDISL--N-------------------K------- Paenibacillus_elgii_498187320 --------F-----------L------LEEDIGMGDIT-MTT-PAESQA-GIIHVKDEGIIAGLSVAEAVFAL-V--RFE-K--DGAAARY-TVI-EVSGSTRSILLGERLALNLLQRMSGIATRTRQFVNRL---LP-RLVDTRKTTPGHRMLEKYAVRVGGGHNHRFGLYDAVMIKDNHIKGAGG-REAI---MAAR-----HT------EVEVETFEQLEEALAAG--I--VMLDNM-----------E-----Q-MSQA----------QRM--NAPVEASGNVTLD-VRGI--AQSGVDVISVGR-TYSVQSLDISL--N--QKGSAGEK---------S------- Paenibacillus_ginsengihumi_518366183 --------F------------------LEEDIGMGDVT-MAT-PAGQQS-GIIHMKDEGIVAGLPVAAAVFKL-V--QFA-K--DGDAVVR-TVL-EVTGSTRSILLGERLALNLLQRLSGIATRTRQFAERI---LP-RIVDTRKTTPGHRLLEKYAVRVGGGFNHRFGLYDAVMIKDNHIKGAGG-AKAI---EAAR-----HT------EVEVESFEQLEEALTAR--I--IMLDNM-----------A-----Q-IKEA----------QRI--RMPVEASGSVTLE-VRAI--AETGVDVISAGR-TYSVQSLDISL--------NEQKE----------------- Paenibacillus_polymyxa_310639532 --------M-----------G------LREDTGSGDVT-RWTEPGH-QS-AVIHAKESGVIAGLPVAEIVFRV-V--SFT-L--DGQWIEK-SVL-EVSGSTHAILTGERLALNLLQRMSGIATRTRTFIDQL---LS-RLVDTRKTTPGHRLLEKYAVRVGGGSNHRFGLYDAVMIKDNHIKGAGG-AQAV---SRAR-----HT------EVETENMTQVREALEAG--I--IMLDNM-----------VP----D-MKEA----------RFI--EAPTEASGNVSLD-VREM--AESGVDVISVGR-TYSFHNLDISL--N-------------------K------- Paenibacillus_sanguinis_517583346 --------F-----------G------LQEDVGSGDVT-AVT-PTGHES-GIIHAKQDGVIAGMPAARLVFEI-V--RFT-L--DGQRVEK-TVI-EVEGSTHRILTGERLALNLLQRMSGIATRTRTFVEAL---LP-RLVDTRKTTPGHRMLEKYAVRTGGGANHRFGLYDAVMIKDNHIKGAGG-AQAV---SRAR-----HT------EVETENLEQVNEALQAG--I--IMLDNM-----------V-----L-MKEA----------HRI---VPVEASGNVSLE-IRDI--AESGVDVISVGR-TYSFESLDISL--N-------------------K------- Paenibacillus_sp_251794106 ------T-Y-----------H------LAEDIGSGDIT-ATT-PMGSHS-AVIHVKESGIIAGLPVAQIVFEI-V--QFE-K--DGEHVEK-TVI-TVEGSTHSLLTGERLALNLMQRLSGIATKTNAFVAAL---LP-RLVDTRKTTPGHRMLEKYAVRVGGGANHRFGLYDAVMIKDNHIKGAGG-RQAV---EASR-----HT------EVEAESLGQVEEALASG--I--IMLDNM-----------ST----L-MTEA----------SLI--SSPVEASGNVRLD-VRAI--AACGVDVISVGG-TYSFNALDISL--N-------------------R------- Paenibacillus_sp_546577354 ------A-W---------LRG---D-SLAEDIGTGDVT-RTT-PAGSNM-AVIHVKEDGIIAGLPVAQTVFSV-V--AFT-H--DGDRVTA-TVI-EVEGSTHSILTGERLALNLMQRLSGIATKTSRFVDIL---LP-RLVDTRKTTPGHRMLEKYAVRVGGGANHRFGLYDAVMIKDNHIKGAGG-TAAV---IASR-----HT------EVETESMEQVGEALDCG--I--IMLDNM------------E----L-MAEA----------RLI--SSPTEASGGVRLE-IRAI--AETGVDIISVGA-TYSFEALDISL--L-------------------K------- Pedobacter_saltans_325104754 --------F-----------K------LAEDLGDGDHT-LST-PKDAKG-ARLLVKEDGVIAGVDVAVEV-NE----NVE-L--DGTEVKV-DVVLYVSGSVQSILVAERLLLNLMQRMSGIATTTHKIVKNL---TG-KVLDTRKTTPNLRYLEKMAVKIGGGVNHRFGLYDMILIKDNHVDYAGG-ENAV------------DY--KNRNEVEVRNLEELRSVLA-GI-R--VLLDNF------------E----D-LKKA---------VAIV--K--TEASGNITPQN-LDY--AKCGVDYISMGA-THSVKGLDLSL--V-------------------G------- Pedobacter_sp_149280739 --------M-----------I------VAEDRGDGDHT-LST-PAGTQG-AQLIIKEDGILAGITLAVEI-SY----VVN-L--DGAAVRY--DIATVSGSTHSILLAERLVLNCMQRMSGIATKTHAIVQMI---YP-RILDTRKTTPGLRYLEKWAVRIGGGVNHRIGLYDMILIKDNHVDYAGG-KNAI----AANL----D-------EIEVRNLSELNDVIE-GI-R--IMLDNF------------D----D-LKKA---------VSTI--G--SEASGGITEEN-EYA--A-CGVDFISIGA-THSVKSLDMSL--A--------------------------- Phaeodactylum_tricornutum_219129720 ---E-S-YST-PKIIE--VK----QW-IADDIPSFDVGGL--VVGDGTR-ATLWLKSPGVFAGKPFFDSVFEL-L-CVVEWNSDEGN-FVNASI-AVVTGPIHKILQGERTALNTLSRCSGVASASYEAV-LAKAGWKGWVAGTRKTTPGFRIVEKYGLLVGGAATHRLDLSQMVMLKDNHIWSAGSISAAV---QRAR-QAAGFSQKI---EVECQNLEEAIEASKAGADI--VMLDN------------PE-------KID---------AKS-KFPILIEASGGITTETMHLY-LCDS-VDIVSQG---QGYSCLDYSL--V--------------------------- Physcomitrella_patens_168048902 --------------------V------LAEDAGDGDVT-LAT-TPDVQA-AQFLAKANGVIAGIALAEMV-TE-V--EWT----DGDLITKGQQF-TVRGAAQSILTAERVVLNFMQRMSGIATLTKAMAEA-----K-RILETRKTAPGLRLVDKWAVLIGGGENHRMGLYDMVMVKDNHIAVAGGIQQAI------------NY--SNLKEIETRTLEEVQEVL----GK--VMLDNM------------E--DVL-LQQA---------VSMIE-G--TEASGNVTLDT-SKI--GSTGVTFISSGA-THSVKALDIS--NAG------------------R------- Phytophthora_infestans_301091078 --MP-R-FAH-PPSWT--VQ----LW-LEDDIPSFDVGGF--VVGEDEE-ALLLGKSEGVLAGVPFFTEVFR--L-CHVEWLLNEGDEVKPKV--AKVTGKCRQLLLGERTALNILTRASGVTTQARRSV-QASLGWNGHVAGTRKTTPGFRLVEKYALLVAGASTHRHDLSQMVMLKDNHVWAAGSITKAV---HKAK-LAAGFSMKI---EVECRRIEEAQEAAKAGADI--VMLDN------------PE-------KAT---------AAE-KFPLLIEASGGITPETL--Y---SPDVDVVSQG---QGYPCLDFSL--I---------------------LQ---- Phytophtora_ramorum_JGI_2507657097 --MT-N-FAH-PPSWT--VQ----LW-LEDDIPSFDVGGF--VVGEAEE-ALLLAKSDGVLAGVPFFTEVFR--L-CSVEWLLKEGEEVAPKV--ARVTGKCRQLLLGERTALNILTRASGVATQARRSV-QAALGWRGHVAGTRKTTPGFRLVEKYALLVAGASTHRHDLSQMVMLKDNHVWAAGSITNAV---HKAK-QAAGFSMKI---EVECRRIEEAQEAATAGADI--VMLDN------------PE-------KAT---------AAE-KFPVLIEASGGITPETL--Y---SPDVDVVSQG---QGYPCLDFSL--I---------------------LQ---- Polysphondylium_pallidum_281204821 MV-D-V-YSHF-KSLQ--IK----DW-LDEDIPSFDYGGA--VVG-DVE-AFLLGKQRGVFSGTPFFNEIFEL-LDCRVKWNIKDGEEF--PV-LAEVRGAVRNILMGERLSLNILSRSCGITTRAFDLR-IV---VKGKVAGTRKTTPGFRLVEKYAMLVGGCDCHRMDLSSMIMLKDNHVW-GGNITAAV---KKAR-SIGGFSLEV---EVECRTEDEAVEAVEAGADV--VMLDNMLPLAVSKLKYP----------------------------IVIEASGGVIPETLY----ALP-VDIISMGS-CQSVPHIDISL------------------------------ Populus_trichocarpa_224101821 ----------------VS--SSHP---LAEDAGDGDVT-LAT-PFDMEV-AHFLAKEDGIVAGISLAEMI-HE-V--EWS----DGDYVQKGLQF-KVSGQAHNIVVAERVVLNFMQRMSGIATLTKTMAD-----RP-CILETRKTAPGLRLVDKWAVLIGGGRNHRMGLFDMVMIKDNHISIAGGIINAI------------QY--QNLQEVETRTLEEVDEVL--KS--TRIMLDNM------------PNGDVM-LKDA---------VEMIN-R--TEASGNVTLET-HKI--GQTGVTYISSGA-THSVKALDISLKDQG------------------R------- Porphyridium_purpureum_contig_548.3 ---A-V-VESLDTQLR--VR----EW-LREDIPAMDFAGA--VVGSDVR-AHLLQKSPGMLAGVPFVEAVFDE-LGMRVEWHVHEGMRV-HKR-LASVTGPADDLLRAERVALNCLSRCSGIATRADDLM-IAAHGWRGRVAATRKTTPGFRVVEKYGVIVGGADPHRMNLSSMIMLKDNHVW-AGNITKSV---QRAR-ALAGFSVKI---EVECRSLDEAREACHAGADV--VMLDNFDPFKTARVRFA----------------------------VIIEGSGGLSESTLF----FCE-ADVLSMSI-MQNYQCVDFSL------------------------------ Prevotella_sp_546844924 --------M-----------T------LKEDIGSGDIT-LAT-PAGSTT-AIIHAKKPGILAGVDLAREV-AL----KFT-I--DGAEM-D-TSVITVEGDAQAILTGERLSLNLLQHLSGVATRTHQLAELI---YR-KLVDTRKTTPGMRRLEKYAVRVGGGANHRLGLYDAMLIKDNHIKVAGG-TAAL---DRAH-----HM------EIEVENMDGVKEALAAG--V--IMLDNM-----------AD----R-MAEC----------KVI--HA-VEASGGITEE-IVAA--AKSGVDVISVGA-THSVKALDISM--I---------G---------K------- Pyrenophora_teres_311319941 SR-P-A-VAHLPETYK--VS----EW-LEEDTPSFDYGGF--VVGEAVS-AKLLGKSEGIVAGVPFFDEVFRQLCT--VEWHVKEGAAF---I-CATVRGPVRHLLLGERVALNTLARCSGIATKSNRLL-LLNAGYPNILAGTRKTTPGFRLVEKYGMLVGGVDAHRVDLSAMTMLKDNHIVAAGSITNAV---RAAK-AAGGFAIKV---EVECQSFEEADEAIAAGADI--VMLDN--------TPVQ---------AKDKDKWGRGTDRK-----FLVEVSGGLTEHNVY-----CG-IDIVSTS--HQGVPHVDFSL---SKKDSGETSV-----------LTSSAQ Rhizophagus_irregularis_552921220 ---S----AHLSPSYK--IS----NW-LKEDVPSFDYGGF--VVGE-AQ-AILYGKSAGVVAGIPFFEEVFNQ-LECRVEWNLKEGEEFE-K--VARVYGRACNILLGERTALNILARCSGIATRSKKCI-LKKCDFRGVIAGTRKTTPGFRIVEKYGMLVGGADTHRMDLSSMIMLKDNHIWSQGSIKKAI---GRAR-KIGGFSLKI---EVECLSEQEADEAIEAGADI--IMLDN----------KG---------LKQAKTLKQRWGKR-----FLIESSGGISEENI-----FSPDIDILSMGS--QGVPHVDFSL--I--------------------------- Rhizopus_delemar_384494577 ---A----SDLATNYK--VS----QY-LAEDVPSFDYGGY--VVGEEEQ-AVLYMKAEGVLAGVPFFDEVFKQ-LDCRVEWCHKEGEYIK-KE-MARVYGSARKILLGERTALNIICRCSGIAFRARQVY-LKAKGFKGIIAATRKTTPGFRLVEKYGVLVGGLDTHRMDLSAMVMLKDNHIWSSGSITKAV---ENAR-SVCGFALKI---EVECQSEEEADEAIEAGADI--IMLDN---------FEG---------VAANIKERWAAGKN-----FLIESSGG----I-YNLLDKCDQVDIFSTDFCQQGTSTLDLSLQQIEEKEAERRRE-------------EYLS Rhodothermus_marinus_345302083 ------ATW-----------P------LAEDIGPGDVT-EAT-PPDQQA-GLFLAKANGVVAGLQVAARV-QL-VD-CWQ----DGSRVTAGTLF-TVEGRARSLLMAERLALNLLQRMSGIATATRRLVERV-PYTK--VLDTRKTAPGLRLLDKWAVRLGGGTNHRLGLYDMILIKDNHIVAAGGIREAI---EAA------HR--I---EIEAQSLEDVD-AI-AGV-W--ILLDNF---------ARVE----P-LREA---------VRRIG-G--TEASGNITLET-EAI--AATGVEAISCGA-THSVQALDLSL--S-------------------A------- Ricinus_communis_255570096 ---------------LTL--SSHP---LAEDAGDGDVT-IAT-PSEMEV-AYFLAKEDGIIAGIALAEML-HE-V----L----EWSRVHKGLQF-KVSGRAHNIVVAERVALNFMQRMSGIATLTKAMAD-----SP-CILETRKTAPGLRLVDKWAVLIGGGKNHRMGLFDMVMIKDNHISIAGGIINAI------------QY--QNLQEVETRTLEEVNEVL--RT--TRIMLDNM------------PNGDVM-LKNA---------VELIN-G--TEASGNVTLET-HKI--GQTGVTYISSGA-THSVKALDISLKDQG------------------R------- Saccharomyces_cerevisiae_19705600 ---P-V-YEHLPVNWR--VT----NW-LSEDVPSFDFGGY--VVGSDLK-ANLYCKQDGMLCGVPFAQEVFNQ-CELQVEWLFKEGSFL-PKI-VAKITGPAKNILLAERTALNILSRSSGIATASHKII-LASTGYKGTIAGTRKTTPGLRRLEKYSMLVGGCDTHRYDLSSMVMLKDNHIWATGSITNAV---KNAR-AVCGFAVKI---EVECLSEDEATEAIEAGADV--IMLDNFKGLKCAQLKWN---------KH-----------------FLLECSGGL-----L-DEYLCD-IDIYSTS--HQGTPVIDFSL------------------------------ Saccoglossus_kowalevskii_291224699 ----MG-PQHIHPTLK--VR----QW-LNEDTPSFDYSGF--VVGERQE-AVLLCKSPGVLAGVPFFTAIFEE-LDCNIEWLVEEGSLLEPVC-IAIITGKVKNLLLGERVALNCITRASGIASYARQMN-IAHAEWHGEVAGTRKTTPGFRLVEKYSLLVGGMSTHRYDLSSMIMLKDNHIWTAGNISQAV---KDAK-KVGGFSTKI---EVECRSVSEATEAATAGCDI--VMLDN------------PQ-------HVA---------AKQ-KFPLIIEASGGINEE-ITQY--MGT-IDVLSIG--TQGYNTVDFSF-------------KERNPHNPV-N------ Salisaeta_longa_551207634 -------MY-----------A-----VLEEDVGPGDVT-QAT-PQGRTA-ATLTAKEAGCVAGLHVAARV-ST-VD-RFT-Q--DGARVAAGTVV-GVHGPARALLTAERLALNILQRMSGIATATHRMVEAV---HD-DILDTRKTAPGLRTLDKWAVRLGGGTNHRLGLHDLILIKDNHIAAAGGIAEALDATRAA--------------EIEVRTLDELD-AV-GGA-I--VLLDNM-----------VR----TTLQAA---------VERVG-G--TEASGNVRLDT-RAI--AATGVDAISSGA-THSVRALDLSM--D--------------------------- Salpingoeca_rosetta_326430421 -----A-YDG-PE--R--VR----AW-LAEDVPSFDIGGA--VVGTKQE-ATLLCKSPGVLAGRPFFDAVFRHLCK--VTWEREEGEMLAPRI--ATVQGEARKILLGERVALNTLARASGIATRSRKMI-LKEKGWKGVVAGTRKTTPGFRLVEKHAMLVGGADCHRMDLSSMVMLKDNHIWSQGSIPAAV---SKAR-DMAGFSVKI---EVECGTEEEAREAIAAGADV--VMLDN------------PD-------GCA---------AAR-KHPIIVEGSGGITVESIYM----HPSVDVLSTS---QGTPHVDFSL--I--------------------------- Scheffersomyces_stipitis_126138416 ---S-A-YANLPVNWK--IT----DY-LTEDVPSFDFGAF--VVGDKVE-ASLYMKQAGLICGVPFAAEVFKQ-TELEVIWHYKEGQYIN-KI-VATVKGPANKILLAERTALNLLARASGIATQSY--ITLAESGYTGLIAGTRKTTPGLRHLEKYSMLVGGVDTHRYDLSSMVMLKDNHITSTGSITKAV---KSAR-SVCGFAVKV---EVEVSTEDDAREAIDAGADV--IMLDN--------SGLQ---------AH--NLKSYYKSQK-----YLLECSGGLTLHNLF----LCN-IDIYSTS--HQGTGIVDFSL-------------------------N---- Schizochytrium_aggregatum_Schag1_96276 ---P---MK-LPLSWR--DD----NW-MAADAPNFDVGGF--VVGDDVK-AHLLGKSPGVMAGRPFAQAVFDV-AGVEVEWLVADG-VIS-KK-VAIVRGPVRKILIAERTALNVMSRASGIATAAREMAEIKAHNWHGEVAATRKTTPGFAIVEKYAVLVGGCSTHRMTLSQMVMLKDNHVWSVGSIPDAV---KKAR-RAAGFSSKI---EVECRDLDEAIQAATAGAEV--VMLDN---PELKVAAKE---------------------------PVLIEASGGIT-ETTY----FSP-VDVLSMG---QGYGALDFSL-------------R---------------- Schizophyllum_commune_302696823 -------YEHLPPSWK--VT----AW-LAEDTPSFDYAGF--VVGDVER-AFLFGKGDAVLAGSPFFTEVFEQLCQ--VEWHVKEGDTF--KH-VATVRGRARHLLLGERVALNMLARCSGIATKSKRVK-LAGYGFKGIIAGTRKTTPGFRLVEKYGMLVGGIDPHRHDLSSMIMLKDNHIWSHGSITAAI---KQAR-LVGGFSLLL---DVEVRSEEEANEAIDAGADI--VMLDN----------EG---------LVAAQRLKEKWGQR-----FLIETSGGITEGNLR-----IN-VDILSTS--HQSVQHIDFSL------------------------PN---- Selaginella_moellendorffii_302794630 --------M-----------GPVH---LSEDAGDGDVS-LAT-PAEMTA-ARFLAKENGVIAGIALADMV-QE-L--DWA----DGSTVEKG-QVFKVCGNARSILTAERVVLNFMQRMSGIATATKKMADA-----K-RILETRKTAPGLRLIDKWAVLIGGGENHRMGLYDMVMVKDNHIAVAGGIENAI-----A-------Y--EGLDEVETRTLDEVRRVLI-K-----IMLDNM------------Q--DVL-LREA---------VEIVG-G--TEASGNVTLST-GKI--GSTGVTYISSGA-THSVSALDISCKDAG------------------R------- Sorghum_bicolor_242045540 --------M---A-L-----NARP--DLAEDAGDGDVS-LAT-PSDVEA-ATFIAKADGVIAGISLADMI-NQ-V--KVE-F--DGNYVHKGLQF-KVYGCARSIIVAERVVLNFMQRMSGIATLTKAMSDA----RP-CILETRKTAPGLRLVDKWAVLIGGGKNHRLGLFDMVMIKDNHISVAGGIANAMDFLQKE--------------EVETRTIEEVKDLL------TRIMLDNM------------ANGDVM-LKDA---------VQLIN-G--TEASGNVTIDT-KKI--GETGVTYISSGA-THSVKALDISLKDQG------------------R------- Spizellomyces_punctatus_SPPG_08064.3 ---P---LSHLPTNWK--VS----SW-LDEDTPSFDYGGF--VVGT-DQ-AILYGKAPGVLAGVPFFDEVFRQ-VDCRVEWFLKEGEFFS-RK-VAKVHGHARNLLLGERPALNMLARASGIATRARRLR-LKKHNWKGVIAGTRKTTPGFRIVEKYAMLVGGVDTHRVDLSSMIMLKDNHVWATGSITNAV---RAAR-STGGFALKI---EVECRTEAEADEAIEAGADI--IMLDN----------DG---------LISAKKLKDRYGKR-----FLIEGSGGLTEENV-----FGEGVDVLSFGS--QSVPHIDFSL--V--------------------------- Synechococcus_elongatus_56750600 ------IMW-----------L------SREDLGRGDHS-QLG--EG-TG-ATWVAKSEGIIAGLPIAFRM-QL----KCT-K--EGFACGSGQVIAELEGPLASLLSGERAALNVAMRLSGVATATRRFVDQL---LP-QFVDTRKTTPGLRLLEKYATRVGGGTNHRLGLDDAVMVKDNHIAAAGGIAAAI----KL--SQLPFP------EVETETLGQVMEAISAGV-V--IMLDNM------------A----Q-VQAA----------QVIR-D--IEVSSNISLEN-RAI--AETGVDYISSSAPTRS-PWLDISM--L--------------------------- Synechococcus_sp_170076994 --------L--------P--I------LQEDLGRGDRTSLFA-PI---G-AKLILKADGQVAGLPLVERV-QL-L--KFE-A--EGS---S-QPIATMTAPLDILLMGERVALNILMRLSGIATMTAQYVEKI---LP-QLVDTRKTTPGLRLLEKYAVQVGGGQNHRFGLDDAVMIKDNHIQAAGG-SQAI----LV--QNMPYP------EVEAETPEQAFEAVTAGA-I--LMLDNM------------A----M-MADL--------PLRAKN-P--LEASGNITLET-REA--ALTGIDYISTSATTR-APWLDISM--I-------------------A------- Synechococcus_sp_427714595 --------L-------PH--I------LQEDIGRGDRT-QLG-GEQ--G-AELEIKQAGMIAGLSIFGRV-QL-L--AQI-L--QDGEPAN-SQIARVTASLETLLLGERVALNLVMHLSGVASLTRIYADLI---LP-QLVDTRKTTPGLRLLEKYATQVGGAINHRLGLDDAVMIKDNHIQAAGG-AQAL----QI--TQIPFT------EVETETLGQVQTALAAGA-I--IMLDNM------------E----R-MTQA--------MIRHQR-P--IEASGNITQET-RTV--ALTGVDYISTSATTRSPW-LDCSL--L-------------------E------- Takifugu_rubripes_410932074 ---------HIPPHLT--AR----EW-LEEDTPNFDPAGV--CVGLRDV-ARLLCKTPSVLAGSPFFTAVFRE-LGCSVHWLLQEGSETGPVT-AAVVRGPARCLLLGERPALNCLARASGIATRCSQLR-LAAAGWHGQVAGTRKTTPGFRLVEKYAMLVGGVSMHRQDLSGMVMLKDNHIWASGSITQAV---GSAR-SVCGFSSKI---EVECRSVEEASEAATAGADV--IMLDN------------PQ-------HAA---------AQA-KFPQVVEASGGVTPE-LSSY--FSP-VDIISLG--TQGCPVVDFSL----------------------K------- Thalassiosira_pseudonana_224008214 -------LSS-PP--P--VF----QW-LQDDMPSFDVGGH--VVGISIQ-AELWMKSPGILAGIPFFEQVFKV-CGCTIEWHEEEGTFLAAKV--ATVTGPVSHLLRGERTALNSLSRCSGVASLSNKCV-IAKGNWHGLVAGTRKTTPGFRLIEKYGLLVGGAATHRLDLSQMVMLKDNHIWSTGSITNAV---TKAR-KVSGFSQKI---EVECQSLEEANEAAEAGADV--VMLDN------------PD-------KVD---------AKT-KYPVTVEASGGITMDTMY-----SESVDVISLG---QGYDCVDFSL--I--------------------------- Thermobacillus_composti_430751789 --------F---------------S-MLDEDIGYGDIT-EST-PAGSRH-AVIHVKEDGVLAGLPVARLVFHV-V--EFR-L--DGQKVAK-TVI-EVEGSTHSILTGERLALNLLQRMSGIATKTRRFVDAL---LP-RLVDTRKTTPGHRLLEKYAVRMGGGANHRFGLYDAVMIKDNHIKGAGG-RAAV---AAAR-----HT------EVETETIEQVREALEAG--I--IMLDNM-----------PA----G-MAEA----------KLI--EAPIEASGGVRLD-IREI--AATGVDIISVGG-TYSFDSLDISL--L-------------------K------- Trametes_versicolor_392568318 ---S-E-FEHLPPSWK--VT----AW-LQEDTPSFDYGGF--VVGEAPR-AFLLGKGSAVLAGAPFFTEVFTQVCE--VEWHLKEGETF--KH-VATVRGKARHILLGERVALNMLARCSGIATQSKKIK-LAANGYKGIVAGTRKTTPGFRLVEKYGMLVGGIDPHRHDLSSMIMLKDNHIWSSGSITNAI---KQAR-KVGGFSLLL---EVEVGSEAEANEAIDAGADI--VMLDN----------EG---------LVGARRLREKWGER-----FLFESSGNITEANLR-----IN-IDILSTS--HQSVQHIDFSL------------------------PN---- Trichoplax_adhaerens_196001563 -----N----VSKVVE--VN----QW-IQEDIPNFDYGGY--VVGEKVE-AVLLCKSEGVIAGQPFVQGIYDK-LGCQIQWKVEEGTLIQPIA-VAQVQGPVNKILMGERISLNCICRASGIATRARYLH-LASAQWHGEIAGTRKTTPGFRTVEKYSLLVGGISTHRFNLSSMVMLKDNHIWSVGNIEAAV---KKAR-QACGFSTKI---EVECRSLEEGCQAAKAGADI--IMLDN------------PD-------HRS---------AAA-KYPVLVEASGGITVD-INSY--FVP-VDVISLS--IQGCPVVDFSL-------------KETVPRIHT-T------ Ustilago_maydis_71020357 -M-P-V--ANLPPSWK--VS----EW-LAEDCPSFDWGGF--VVGEDKK-ATLFCKSEGILAGVPFFDEVFKQ-LDCRVSWNFREGEWL--KI-VATVEGPSRKILLGERVALNTLARCSGIATASGLFL-KADAGYNGIVAGTRKTTPGFRDVEKYGMLVGGVDMHRYDLSSMVMLKDNHIWSTGSVTNAV---HSAR-SVCGFSLRI---DVEVQSYQEAVQAIEAGADV--IMLDNMEGLI---NALK------------------EWGKH-----FLLESSGGI----DV--GGHVDSIDIISTS--HQSTKHVDFSL------------------------S----- Vitis_vinifera_297737712 ---------------------SHP---LAEDVGDGDVT-MAT-PDDMEV-AHFLAKEDGIVAGIALAEMV-NE-V--EWS----DGDYVHKGLKF-KVHGRAHNIVRAERVVLNFMQRMSGIATLTKAMADA----P--LILETRKTAPGLRLVDKWAVLIGGGRNHRMGLFDMVLIKDNHISIAGGVTNAL------------SY--KNLQEIETRTLEEIKDVL--KT--TRIMLDNM------------LNGDVM-LKEA---------VELIN-G--TEASGNVTLET-HKI--GQTGVTYISSGA-THSVKALDISLKDEG------------------R------- Volvox_carteri_302845584 -------TY-----------ASHP---LEEDAGDGDVT-LAT-PPETQA-ATFTAKSVGIVAGFGIADEV-AT-V-VQVE-R--DGDRVDQG-QV-GVRGSARAILVAERVMLNFMQRMSGIATATAAMVSAL---LP-KVLETRKTAPGLRLLDKWAVLIGGGTNHRMGLYDMMMIKDNHIAAAGGIRAAV----RA------EY-RGGDSEVETSTLEEVDEVVEPGAHLRRVMLDNM---------ARKE----GTLAEA---------VGRIG-D--TEASGNVTLSS-RTI--AATGVTYVSVGA-THSVTALDISL--I-------------------T------- Xenopus_tropicalis_301622624 -----D----LPPRLQ--AR----DW-LAEDAPWLD-IA-----GWAAS-AVLLCKSAGVLAGGPFFQAVCEE-AGCTVQWEHRDGEWLEPVT-VATVKGRVNDLLLAERPALNALSRISGVATLAREAS-KAATGWPGLVTGTRKTTPGFRLPEKYGLLVGGAGTHRYGTTDLVMLKDNHVWAMGGVKEAL---DGVR-ALAGKTLKV---EVECRSLEEALDAAAAGADI--VMLDN------------PE-------HAA---------ALA-KYPVVIEASGGVTFT-LQQF--LGA-VDMVSMG--TQGSPSIDFSL---------------HGLRRKTL------- Yarrowia_lipolytica_50552482 ---M-S-FAHLPIDWK--VT----RW-MSEDVPSFDVGGY--VVGDDIH-ATLYCKSPGVVAGVPFAQEVFDR-NQLKVKWSVREGDYV-PKV-VAKVSGPVRQVLLAERTALNLLARASGVATKSRHIV-LAKAGYTGIIAGTRKTTPGLRRLEKYAMIVGGADPHRYDLSSMVMLKDNHVWATGSITDSV---KKAR-SVCGFAMKI---EVECQSEEEANEAIAAGADI--IMLDNFDGLQAAQIKWN---------KH-----------------FMLECSGGLTEENIY----LTN-IDIYSTS--HQGTGIVDFSL-------------------------N---- Zygosaccharomyces_rouxii_254583213 ---A-H-YENLPSNWK--IT----NW-LQEDVPSFDYGGF--VVGSDQK-ATLFCKQDGYLSGVPFANEVFKQ-CELQVEWYFQEGDQL-IKL-VAKVTGKAKDVLLAERTALNILSRSSGIATSSRRLM-AASVGYRGTIAGTRKTTPGLRRLEKYSMLVGGCDPHRYDLSSMVMLKDNHIWSTGSITNAV---YAAR-RVCGFAVKI---EVECQSEQEADEAIEAGADV--IMLDNFEPLKCASLKWK---------RE-----------------FLLECSGGL---KLL--GYLCP-IDIYSTS--HQGTGVVDFSL------------------------------ halophilic_archaeon_544604960 ----------LT------VE----TW-LREDI--G-HRD---VTN-VPG-TTLVPTEPGVAAG---LDAVFEY-LGVDVQVQVEEGHQLDPPA-VA--EGPAQDVLRGERVAVNVAAHASGVATRT-EAVDAAE--DE-RIAGTRKTTPGLRGIEKRAVAAGGGDTHRLTLSGMVMVKDNHI--ELGFDRAI---ERIR-ERTSFATKV---EVEVEEPGDAVRAAEAGADV--VLLDN------------PA-------ERG---------V-A----VLAEASGGISM-DVP-Y--AAT-VDIISLGS--HSAPALDYSF------------------------------ ; END;