#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 18, 2025; 21:25 GMT TreeBASE (cc) 1994-2008 Study reference: Ternes C.M., & Schoenknecht G. 2014. Gene transfers shaped the evolution of de novo NAD+ biosynthesis in eukaryotes. Genome Biology and Evolution, . TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S15669] BEGIN TAXA; TITLE Taxa; DIMENSIONS NTAX=134; TAXLABELS Acyrthosiphon_pisum_328720850 Ajellomyces_dermatitidis_261205294 Albugo_laibachii_325192212 Allomyces_macrogynus_AMAG_17335 Alteromonas_macleodii_407699945 Aminicenantes_bacterium_551142562 Aplanochytrium_kerguelense_Aplke1_105217 Aplysia_californica_524866320 Arabidopsis_thaliana_42568561 Ascaris_suum_541047205 Ashbya_gossypii_302309350 Aspergillus_nidulans_67522577 Aspergillus_niger_145244667 Aspergillus_oryzae_169769204 Aurantiochytrium_limacinum_Aurli1_32548 Babesia_bovis_156087951 Bermanella_marisrubri_494076806 Branchiostoma_floridae_260830087 Brugia_malayi_170589299 Buchnera_aphidicola_15617045 Caenorhabditis_elegans_71997862 Caligus_rogercresseyi_225709256 Cand_Kuenenia_stuttgartiensis_91202924 Cand_Riesia_pediculicola_295698311 Cand_Vesicomyosocius_okutanii_148244464 Capitella_teleta_443691813 Chlamydomonas_reinhardtii_159469087 Chlorella_variabilis_307104732 Ciona_intestinalis_459173389 Clostridium_tetani_28211675 Coccidioides_posadasii_303311669 Coccomyxa_subellipsoidea_545358533 Cryptococcus_neoformans_405121504 Cyanidioschyzon_merolae_544210593 Cycloclasticus_pugetii_519006632 Danio_rerio_528518142 Daphnia_pulex_321453246 Debaryomyces_hansenii_294655955 Desmospora_sp_497395288 Dictyostelium_discoideum_66805693 Dictyostelium_fasciculatum_328874203 Dictyostelium_purpureum_330845458 Drosophila_melanogaster_19528069 Echinococcus_granulosus_556515322 Ectocarpus_siliculosus_298705733 Entamoeba_dispar_167380300 Entamoeba_histolytica_67472722 Entamoeba_invadens_471208618 Escherichia_coli_487633144 Firmicutes_bacterium_547821648 Galdieria_sulphuraria_545709277 Gayadomonas_joobiniege_516014004 Giardia_intestinalis_253742205 Giardia_lamblia_159108475 Gilvimarinus_chinensis_519052214 Glycine_max_571506330 Hahella_ganghwensis_521078440 Halomonas_elongata_307544784 Halomonas_lutea_517847798 Halomonas_zhanjiangensis_517747105 Hippea_alviniae_550921245 Homo_sapiens_18652051 Lamprocystis_purpurea_521993334 Legionella_drancourtii_493928026 Leishmania_braziliensis_154335346 Leishmania_infantum_146083652 Leishmania_major_157867676 Lepeophtheirus_salmonis_225712656 Loa_loa_312066533 Lottia_gigantea_556108217 Marinobacterium_rhizophilum_522174335 Methylomicrobium_alcaliphilum_357405202 Methylotenera_mobilis_518740026 Methylotenera_sp_519028046 Meyerozyma_guilliermondii_146423687 Monosiga_brevicollis_167526969 Mortierella_verticillata_MVEG_05231 Mus_musculus_57527870 Nematostella_vectensis_156405737 Neosartorya_fischeri_119470062 Neurospora_crassa_85086139 Oikopleura_dioica_313242099 Oxalobacteraceae_bacterium_522193879 Pedobacter_arcticus_515829424 Penicillium_chrysogenum_255932279 Perkinsus_marinus_294890669 Physcomitrella_patens_168052241 Physcomitrella_patens_168052243 Physcomitrella_patens_168067837 Phytophthora_infestans_301120488 Phytophthora_ramorum_JGI_2507661889 Phytophthora_sojae_348676426 Plasmodium_berghei_68063625 Plasmodium_cynomolgi_457873656 Plasmodium_falciparum_124513330 Plasmodium_knowlesi_193810136 Plasmodium_vivax_156099184 Plasmodium_yoelii_82752821 Polysphondylium_pallidum_281208603 Populus_trichocarpa_224123176 Porphyridium_purpureum_contig_3419.3 Pseudoalteromonas_sp_494620031 Psychromonas_ingrahamii_119944941 Psychromonas_sp_470478781 Rhodanobacter_sp_495486361 Ricinus_communis_255563474 Saccharomyces_cerevisiae_6323360 Salpingoeca_sp_326431706 Saprolegnia_diclina_530740957 Scheffersomyces_stipitis_150951341 Schizochytrium_aggregatum_Schag1_83217 Schizosaccharomyces_pombe_429241520 Selaginella_moellendorffii_302756067 Sorghum_bicolor_242066962 Spiribacter_sp_554595317 Spironucleus_salmonicida_558601652 Spizellomyces_punctatus_SPPG_01224 Strongylocentrotus_purpuratus_390336005 Tetrahymena_thermophila_146165677 Theileria_annulata_65303484 Theileria_parva_71026135 Trichomonas_vaginalis_154423037 Trichoplax_adhaerens_196009472 Trypanosoma_brucei_72389282 Trypanosoma_congolense_342181069 Trypanosoma_cruzi_407838812 Ustilago_maydis_71024819 Veillonella_parvula_490831099 Vitis_vinifera_296089926 Volvox_carteri_302828098 Xanthomonas_oryzae_188577783 Xenorhabdus_bovienii_290476194 uncultured_bacterium_406979593 uncultured_bacterium_406999011 ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M21786] TITLE 'Nicotinate-Nucleotide Adenylyltransferase Alignment'; LINK TAXA = Taxa; DIMENSIONS NCHAR=322; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 ] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] Acyrthosiphon_pisum_328720850 MFL---------------------------------------------------------------------------------------------------------------KNIILLSTGSFNPPTNMHLRMFEIARDHLNRTICGGLMSPTHDSYKKKDLAPSLHRCAMIEQALVALPWVKM-SDWEVK-QNGWTRTRQVLQYHQNHLRAVNVRLLCGADLLESFAVPGLWNDDDIEAIVRDYGLVVVSRSGSNPHKFIIVVTEWITNEVSSTKVRRALSRNESVKFLISELVESYIKEHGLYETNKTHKTYQMDRYQ Ajellomyces_dermatitidis_261205294 MVD--------------------------------------------------------------------------------------------------GKGNPYKFPDHRLTPLLLVACGSFSPTTYLHLRMFEMAADYIKFELIGGYLSPVSDAYKKAGLASAVHRVAMCQLAVETSNWLMV-DPWEPM-QKEYIPTAKVLDHFDHYIKPVHVALLAGADLIHTMSTPGVWSEKDLDHILGRYGTFIVERAGTDIDEAIYVIQQLIQNDVSSTKIRLFLRREMSVRYLIPSPVINYIEKHHLYED----------PSG Albugo_laibachii_325192212 MR------------------------------------------------------------------------------------------------------------------RVLIYGLSANPPTGGHLGIIRHFQQR------EIWILPVYHMYEKSNLATLQHRVEMCQLAVAAIPQIS-VRVLETERSIRDVGTIDVIHHLRE--PLTRFSLLLGTDAFADLVA-GKWK--NGEEILQTIDIIVVQRPNSRHM-DIEFISVPGLQAISSTMARSCRDFQ-ELCKYVDRAVAEYIVKNSLYGF----------ASD Allomyces_macrogynus_AMAG_17335 MSQ----------------------------------------------------------------------------------------------------AAIYTFPDAKLEPLVLVACGSFSPITYLHLRMFEMAIDYLREEVLGGYFSPVNDAYGKPGLAPASHRVAMCRLAVAPSEWLMV-DPWEAA-QPAYMRSADVLDHFDQELRAVRIMLLAGGDLIESFGTPNLWAEADLHRIMGEYGCVIVERTGTDVWGFVFVVKQLIYNDISSTKVRLFVKRNMSIKYLVPDPVMHHIYAHQLYVG----------DRD Alteromonas_macleodii_407699945 MSL---------------------------------------------------------------------------------------------------------------PAVKAILGGTFNPPHKGHISAALKAADEIG--VNVVHLMPCKLAPHK-VGVSETHRVKMIELCAENNDRLI-PELIELTL-PSPSYTVKTLRALKQK--DETICFFIGADSLYNLDK---WY--EWEHLLDYCHLVVMRRDDEQFSPPVVLTS-TPLYSVSSTEIRDVLANARSSDLWLEESVLEYINEHQLY-------------KS Aminicenantes_bacterium_551142562 MKT----------------------------------------------------------------------------------------------------------------ERIGLFGGTFNPIHSGHIRAIEIVQKKFS--LDKILIIPSYIPPHKNGIASPKNRLKMVKLAACSSSIFV-PSSIEIEE-KTKSYSIITLNKIKNLY-NAYIFFILGIDAFLEIHT---WK--DYEKVLDQCFFVVVSRSGYKLEDAIFLLP-IPGLDITSSEVRGRIKKGGSIDGLVPEAVKNHIKNKKLY--------------K Aplanochytrium_kerguelense_Aplke1_105217 MST---------------------------------------------------------------------------------------------------------------TMNVAIFGSSFNPPHNGHIAAFDE-----------VWVLPVYHAYSKSNLPTYEEREQLAKLAFDGIENV--VKPVEKDAEDFTMGSIDVIQYLKT--KDINFSWIIGADSYQDICA-GKWK--CGKELLEEVSMQVMDRKGYEPC-NTQFHNIPELPEISSTFIRSCSDES-ELQALVPKTIADVIVQRKLYGF----------GSC Aplysia_californica_524866320 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLKAALKSSDWIKM-DTWESD-QSSWSPTAKVLRHHRQQTPAPCVKLLCGADLLESFAVPGLWQEEDIDYIVGQHGLVVITRSGSDPHKFIYIVTEWIYNDISSTKVRRALRRGDSVKYVVQDTVIDYIRQHQLFGV----------TCV Arabidopsis_thaliana_42568561 MDV-----------------------------------------------------------------------------------------------------------VEKLTCVVLVATGSFNPPTFMHLRMFELARDELRSHVLGGYMSPVNDAYKKKGLLSAEHRLEMCNVSCQSSDFVMV-DPWEAS-QSNYQRTLTVLSRVKTFLESLKVMLLCGSDLLLSFCTPGVWIPEQLRTICKDYGIVCIRREGQDVENMVKIVDNTVPNQISSSRLRQCISRGLSVKYLTEDGVIDYIRQHQLYT-----------ELT Ascaris_suum_541047205 MDG---------------------------------------------------------------------------------------------------------------RRVALLACGSFNPPTYMHLRMFVRARDYLEKVVVEGILSPVADSFRKPDLLTAEHRLKMVQLAVRNSTWLRA-DGWECS-QSEWTRTLHVLNHFKKQLSGIRLMFLCGGDVVESFAKTRIWNPEHVEEIVRDFGLVVIARTNSDPMKTIHVIDETCPNDISSTRLRTAVRRRESIRYCTDDEVISYIEKNNLYSFDSPNYDNVTLTTV Ashbya_gossypii_302309350 MDP-----------------------------PDSIPENGPIMLADYNSIDAPIPKSYMNSSQPSNCSKGRGGSGS------SSSECGESHAADSSKMVQA--PCLYEFPTHRLLPLVIVACGSFSPITHLHLRMFEMAMDAIVEEVVGGYYSPVSDNYNKPGLASATHRVRMCELACETSSWLMV-DAWESL-QPQYTRTAKVLDHFNDEIIGVKIMLLAGGDLIESMGEPNVWADADLHHILGNYGCLIVERTGSDVRSFILVIKQMIYNDISSTKVRLFIRRGMSVQYLLPNSVIRYIQEYGLYVN----------NKD Aspergillus_nidulans_67522577 MTE----------------------------------------------------------------------------------------------------MPVYVFPEYRLTPLLLIACGSFSPITFLHLRMFEMAADYVKLEIIGGYLSPVSDAYRKAGLASANHRIAMCQRAVDTSDWMMV-DTWEPM-HKEYQPTAIVLDHFDYEIKRVQVVLLAGADLVHTMSTPGVWSEKDLDHILGQYGTFIVERSGTDIDEAIHVIQQLIQNDVSSTKIRLFLRRDMSVRYLIPDPVIEYIYENNLYMD----------PSN Aspergillus_niger_145244667 MTD----------------------------------------------------------------------------------------------------SSMYAFPELRLTPLLLVACGSFSPITYLHLRMFEMAADYVKFELVGGYLSPVSDAYRKAGLASAEHRVAMCQLAVDTSDWLMV-DTWEPM-QKEYQPTAVVLDHFDHEIKPIQIALLAGADLVHTMSTPGVWSEKDLDHILGKYGTFIVERTGTDIDEAIHVIQQLIQNDVSSTKIRLFLRRDMSVRYLIPVPVIHYIEQHNLYKD----------SSG Aspergillus_oryzae_169769204 MTD----------------------------------------------------------------------------------------------------PAMYQFPELRLTPLLLVACGSFSPITYLHLRMFEMAADYVKFELIGGYLSPVSDAYRKAGLAAAEHRVAMCQLAVETSDWLMV-DTWEPM-QKAYQPTAVVLDHFDHEIKHVRIALLAGADLIHTMSTPGVWSEKDLDHILGKYGSFIVERSGTDIDEAIHVIQQLIQNDVSSTKIRLFLRREMSVRYLIPVPVIRYIEQHRLYGD----------KSG Aurantiochytrium_limacinum_Aurli1_32548 MSV---------------------------------------------------------------------------------------------------------------RRRVAIFGSSLNPPTGGHQSVVDHFAKL----MVLPVYAHVFD-SKRNSLEPFEHRVAMARLCFAPLEDV--VSTVERDLVEQRLGTYQVLTYLRS-LADTDFVLILGTDTFNDLCS-GKWR--NGPELLSTTEIAIIHREGYPMV-II-YEMGATSEGVSSTGARDACAAGDTMAKYLPLSVIEYIKEHKLYNF----------GAP Babesia_bovis_156087951 MEE---------------------------------------------------------------------------------------------------------------QMRVLLFAGTFDPITTGHLLMLRQCIETEF--FDEIWLLPSGKRTDKAFRVSDECRLEQCHIAIESLSKLS-ICDYEIKL--KNIDSYFTMVHFQQQYPEIDFYFFIGSDLLPQILS---WP--YGKEFVEITKLLVAYREGYPINQVKVKSRKMETSNASSTLARQQL-NCVKCDETLHPEIMHYIMENSLYGT----------QLT Bermanella_marisrubri_494076806 MS------------------------------------------------------------------------------------------------------------------EFVAFGGTFDPVHFGHIISARDVAQQMG--YQQVHLVPCGDAYHKGALTHSTHRLAMLEQALAEEPWLL-ADGRETRR-EGATYTIDTLKDLRSELPDAHIAWVMGSDTADQLTS---WH--NWRSLFELANVIVVRRAHESRPNLALELE-LTPVDISSTDVRCRLKNHQSVADLVPPSVLKYINTLGLYR------------ES Branchiostoma_floridae_260830087 MAA---------------------------------------------------------------------------------------------------------------GRVVLLACGCFNPITNMHLRLFELARDHLEKKVIEGIISPAHDKYGKKGLVPSTDRIAMAQLALSTSDWVRV-DSWESE-QKGWLETAVVARHLKRQVGDVQLKLLCGADLLESFAVPKLWRDEHIKELVSDFGLVVISRAGSNPEKFIHLVTEWIQNEISATKIRQELRRKESVRYLVPDPVINYINEHQLYQP----------ETS Brugia_malayi_170589299 MEK---------------------------------------------------------------------------------------------------------------RQVALLSCGTFSPPTYMHLRMFERARDYLKKEVVEGIMSPVADSLGRPDIVPAKHRLKMVELAVKSSSWIRA-DGWECS-QGDWIRTIHVLHHFKKVFCKVRLLLLCGGDVIESITKLMLWNTKQIEEVVRDFGMVVVMRANTDPVSAIFVIDETCPNDISSTRLRTAIRRKESIRYCTSDEVIQYIEDNSLYGA----------PAM Buchnera_aphidicola_15617045 MK-----------------------------------------------------------------------------------------------------------------KLCAIFGGNFDPIHYGHINLAEKLAKDIS--IKKIILLPNNYPPHRNKQTSISDKIKMIKLAIHNNPLFE-ISYLETKK--NIFYTIDTLKKIRKKIHLEPLCFIIGEDNLQTFYLWK-----NWREILLYSHLLIYPRKHKKQKNDLIFFSHAPCINISSSRIRKNY-YGKNSHSLLPSIVNNYILLKKLYY-----------TNQ Caenorhabditis_elegans_71997862 MGT---------------------------------------------------------------------------------------------------------------EKVVILAVGSFNPPTNGHLCMMEDAKYSLEK-VLEGIMSPVSDGYAKKSLISAKHRLAQTEAATYDSDWIHA-SGWECA-QSEWTATVNVLKHHQQDVSDVNVLLLFGGDVIESFDKFPVWDREDVEEIISA-GIVVRSRPGSDPEQTVHFIKNAISNSISSTSLRAALKEHRSIKYTTPDSVIKYIKDHRLY--------------E Caligus_rogercresseyi_225709256 MSK---------------------------------------------------------------------------------------------------------------MNILLFAAGSYNPPTHMHLRMFEIAKDFLHSHVLGGIVSPVHDDYKKESLSEAAHRRAMLNLCLKEHPFVKL-SRFETE-QGSWTRLRKVLEEHHNLLEPFKILFLCGADLLESFSVPGLWTDEDMEVIVKDFGLVVISREGADPQKFIHIVTEWITNDISSTKVRRALRRHESVKYLIPDEVIEYISKQGLYGT----------HQT Cand_Kuenenia_stuttgartiensis_91202924 MM------------------------------------------------------------------------------------------------------------------NIGIFGGSFNPIHIGHLIVAEEVFQQRK--LSKILFIPTGISPKEGGLIDSFHRYEMVKQAIGDNEHFE-VSDIEIKR-PGKSYTIDTIKILRETYPGSNLFLILGTDMINEINT---WK--DIEELSCMCHFIVVNRFPITLNGEKLMVQ-IPSLDISSTEIRKKLSKGLSIKYLVPERVENYIRKHSLYA------------KR Cand_Riesia_pediculicola_295698311 MIR---------------------------------------------------------------------------------------------------------------YKIQLLYGGTFDPIHLGHLSIIKHLSKVLK--LEKCIILPNRALP-NLPVANIQQRLKMIQLALKNNSSFQ-IDLREIRK-KNFSYTIDTLYSFRNQIWKKPLGFVIGEDVLYSIHT---WF--NWKKILKICNLLVFRRNREKKSSLVYFVN-NPCLSISSTEIRMRKMQKKSCRNLLPDDVLKYINENRIYQ-------------K Cand_Vesicomyosocius_okutanii_148244464 MQK---------------------------------------------------------------------------------------------------------------FKIIGFFGGSFDPIHYGHLKNAAQLKDKLR--LSKLFLMPCDKPVHKQLNFSINQRIDMLHLAIKEFNTLS-IDTREIKQ-NKNSYTINSLKYIQSKYQNNSICLIMGMDSFNTLSS---WE--ECQNFYQYCHLVIMSRPGILTYQKIFFAN-NQMLNISSSTIQGKIKSQKNLSGLLPDSIINYINA------------------L Capitella_teleta_443691813 MAL---------------------------------------------------------------------------------------------------------------QKVVLLCCGSFNPITNMHLRMFELARDALDAKVVGGIISPVNDAYTKPSLVSAKHRSTMIRLALQTSDWIKL-DTWESE-QESWLETLKVLKHHRESIGMPRIKLLCGADLLSSFAEPGLWKDQDIEEIVGKYGIVCITRANANPENFIHIVTEWIHNEISSTKIRRALSRSKSIKYLVQDPVIEYIKENRLYSK----------LDK Chlamydomonas_reinhardtii_159469087 LNP-----------------------------------------------------------------------------------------------------------TDKLTPVVLVAAGSFNPPTVMHLRMAELAADELLRDVWGVYFSPVADSYGKAGLAPAADRLQPLLLPDPEPDLVM--DGWEAA-QPGYTRTLAVLRRQQDRQRPVRAMLLCGADVLASMASPGVWRNPDV--ILREHGVVCIARAGSPLDGLVVLVYDHVGNSISSSAVRAELAAGRPVRHLLPAGVAAYIHARGLY--------------S Chlorella_variabilis_307104732 --------------------------------------------------------------------------------------------------------------------VVLVSCGSFNPPTFMHLRMMELAQQQLMKDVLGSYMSPVNDAYWKQALAAGRHRVRMCQLATADSGGIMV-DSWEVE-QRQYTRTLFVLQRPAAGAVTPRVLLVCGADVLHSMADPTMWRQDLLETLLSNHGVVCVSRNGSDV-ARVTVVEEPVPNEISSSRVRHELEQGHSVRYLTPASVVRYIYDHGLYGT----------ERD Ciona_intestinalis_459173389 ----------------------------------------------------------------------------------------------------------------------------------MHLKMFDLARDYFHKKVKFGGISPTADSYGKPELVNAKHRQNMIKLALQENSWVSL-LDWESN-LNKWTPTEKVLTHYKQNEKELKLFLLCGADLMQSFVTPGLWKESDIRKIVNNFGLVVITRASYDPREFIHIVEECIENKLSSTKIRKAVLEGRSIKYLTPDVVIEYINEHGLYQK----------NKE Clostridium_tetani_28211675 MK------------------------------------------------------------------------------------------------------------------KKAIFGGTFDPIHNGHLHIAYKALNRLK--LDKIIFIPSGNPPHKECITDKNIRYNMVKYAIEQEDKFE-ISDYEVKK-KGKSYTYETIEHFRKYH-NIDLYFIAGADCLMDIHK---WK--NIDSMMEKAKLVVFSRPGFSMDTIIIFLD-IPLLDVSSTEIREKIKKGEDIKDLIPEKTYNIIKKYGLY--------------R Coccidioides_posadasii_303311669 MTG----------------------------------------------------------------------------------------------------SVLYSFPDDRLTPLLLVACGSFSPITYLHLRMFEMAADYVKFELIGGYLSPVSDAYRKAGLASARHRIAMCQLAVDTSNWLMV-DPWEAL-QKDYSPTAKVLDHFDHEIRPVRIALLAGADLIHTMSTPGVWSEEDLDHILGRYGTFIVERSGTDIDEAIYVIQQLIQNDVSSTKIRLFLRREMSVRYLIPGPVIDYIVEHHLYEE----------ASD Coccomyxa_subellipsoidea_545358533 MFP------------------------------------------------------------------------------------------------------ETVLPTDKLKPVVLLSCGSFNPPTYAHLRMFELAAQELTKDVLGGYMSPVHDAYSKKGLAPAEHRVAMCELAAGASPLIMV-DSWEAA-QKQYQYSLHVLQHLERAVTRVRSMLLCGADMVESLTVPGVWRPEHVRHILQDHGLVCIGRIHSDVRRLIVLVEDPIVNEISSTKIRSEMCQGHTVRYLLPDAVVDYIQKNELYC------------SM Cryptococcus_neoformans_405121504 MAS----SEPSLFLTAASHTSTAEESRDPMMSDSPLTEGSQIDALEMDTPPRPAE----------------SPKPA------GAEAKRTTGYDAGRNADLS--GGKYRFPRHRLIPLVIVACGSFSPPTYLHLRMFEMAKDEIVEEIMAGYYSPVSSYYKKSGLAPAPHRVRMCELAVETSTWLMV-DPWEAG-QPEYQRTAFVLDHFDEMLRRYKIMLLAGGDLIESFGEPGVWSEPDLHVILGRFGCLIVERAGSDVWAFVVVIKQLIYNDISSTKVRLFVRRGMSIKYLLPNSVIQYIQDNKLYHG----------GKH Cyanidioschyzon_merolae_544210593 MWV--------------------------------------------------------------------------------------------------------T------RVGVLLSAGSFSPPTLMHLLSLEQAREYVENPVWKGFLSPVHDAYQKPGLVAAKHRLQMCALAVKDSDWVQV-DAWEAQ-QPCYSPTFQVVQSLRERLPGPSVFLVCGADLVASMNNPSIWPVEHLQKLFALCEVVALPRPALDATDEIHYWKDPVQCNISSTLVRERVAHGRSIRYLTPRAVENYIWEHGLYRQ----------SAQ Cycloclasticus_pugetii_519006632 MA-----------------------------------------------------------------------------------------------------------------KFIGIYGGTFDPIHLGHLTAASAVQKEIG--LDEVRMVLSANPPHRAPVLSAEQRFSLLKLAVREYPSLV-ADSCEMER-SGPSYMVDTLSDFRRKY-NDSLVLVLGMEAFNGLMS---WH--RWEELIKLTHIVVTDRAGFDNQFEIYCQS-VKPLDISATQIRQRIKDKKTVKEMLTSQCLDVINKNSFY--------------R Danio_rerio_528518142 MAS---------------------------------------------------------------------------------------------------------------IKLVLLACGSFNPITNMHLRMFELARDHLEDKVVKGIISPVGDGYKKKGLIEACHRLEMARLATESSEWITV-DDWESQ-QPEWVETAKVVRHHHAVLDHSHLNLLCGADVLESFGVPNLWKPEDIEEIVGRYGVTCITRCGSDAEKFISVVREWVTNEISATHIRRALRRGQSVRYLLPDSVVRYIQDHSLYSA----------NTE Daphnia_pulex_321453246 MNK---------------------------------------------------------------------------------------------------------------TRTVLIAVGSFNPPTNMHLRIFELAKDFLQKEVLGGIISPVHDQYGKKGLVSAEHRCSMLKLAVETSNWVNI-SEWETQ-QEGWTRTAESLKFHKKALLNINLKLLCGADLIESFAVPGLWKDEDIEDIVSNYGLVVISRSGSNPQQFISIVPEWITNEISSTKIRRALSRGESVRYLTSDSVSGVSEFDGIVLA----------YHQ Debaryomyces_hansenii_294655955 MDP-----------------------------PSSIPKNIPIELADLGAMDAPSHPSSGRVHMVHEDMKADQYKSK-------SD----NVPEQPPSKSTA--PQLYSFPTHRLYPLVIVACGSFSPITYLHLRMFEMALDAISEEVVGGYFSPVSSNYKKQGLAPAPHRVRMCELACETSSWLMV-DAWESL-QPKYTRTALVLDHFNEEIRGVKIMLLAGGDLIESMGEPDVWADQDLHHILGKYGCLIVERAGADVRSFFLVIKQLIYNDISSTKIRLFIRRGMSVQYLLPNSVIRYIQEHKLYIN----------KTD Desmospora_sp_497395288 MKK---------------------------------------------------------------------------------------------------------------GKKIGIYGGTFDPIHIGHLIMAEQARQAAG--LEEVRFVPAPTPPHKGVSASAEDRFAMVERAVEDHPSFR-VSRVEMDR-SGPSYTADTVRLLCREE-DTRFFLIVGADMVLDLPR---WV--RIEEILASVEVIGLMRPGVKLDMGTWVRE-GVSMNLSSTWIRERVAAGGSVRYLVPEPVRQYMEEHRLYE------------TR Dictyostelium_discoideum_66805693 ------------------------------------------------------------------------------------------------------------------------------------------------------YLSPVGDGYDKKTLIESSHRTTMVELSIEDSDWLMM-DRFESD-KPIFTPTRQVLDHIKLSVCKVNVILVCGSDLLGSFNIPNLWSDNDMNLLSSNFGIAVIPRIGSNLNDIIYLIPADITNDVSSTKIREKLRNKFSVKYLMPDNALNYIKSKNIYKT----------NKL Dictyostelium_fasciculatum_328874203 MTQ---------------------------------------------------------------------------------------------------------FPIDKLQPVVLLACGSFNPITFMHLRMFEICKDWCNNHVIGGYMSPVGDAYKKATLIAAHYRLQIVNLAVMSSEWVMM-DKWESM-NLDFTPTRQVLDHFHLYVRPVQIKLICGADLLASFNVPNLWDEEDM-KIITKYGIICIERPGTNFQEIIYHVPVGITNDLSSTKIRDMISKGLSINYLTEAPVIDYIHKNNLYGY-----------KK Dictyostelium_purpureum_330845458 -----------------------------------------------------------------------------------------------------------------------------------------MANDYYNNEVIGGYLSPVGDAYNKKTLIEAFHRLKMVDLALEDSDWIMA-DPFESS-KNEFTPTRQALDHFKQCTSDLAVKLVCGADLLGSFNIPKLWADSDMDLLSSHYGIAVLERTGTDLEGILDFIPVDISNDVSSTRIREKIRNGGSIKYLIPDKVIDYIYKNNIYKN----------FRK Drosophila_melanogaster_19528069 MSA---------------------------------------------------------------------------------------------------------------PRIAFIACGCFSPPTPMHLRMFEIAKDHFEMRVVGGIISPTHDSYGKKGLASALDRCAMVKLATQSSNWIRL-SDWEVH-QNQWMRTQAVLQHHQNYIDPVHLKLLCGADLLESFAVPGLWAEADIEDIVANHGLVVITRAGSNPGKFITLITNWVPNEVSSTLIRRLLGRGQSVKYLLDDLVLEYIKRQRLFNF----------CDS Echinococcus_granulosus_556515322 MNE----ATADSESYSSYSSSTSTSPRDPAVK--------------------------------SAAMSSERGSPI------SA------PLGKKEDLVVE--PPEGELPTHPCEPVVLVACGSFNPITTMHLRMMELARDAVEKVVVVGILSPVSDAYAKEGLASAASRCRLARLACATSDWLAV-DSWEAS-RTQWTPTRCVLERIQARMLPVRVKLVCGADLLESFNTPNLWSEDDMTALVRDYGIVCISRPGSNAARLVILATEWCQNGLSATLVRRALARGQSVRYLVPDAALEEIYAHGLYGAVIPSLLPPQVTTT Ectocarpus_siliculosus_298705733 MMSSQDV---------------------------------------------------------------------VQGSTRPSPECSN-----------G----AKDLPRARVSKVLIVGSGTFNPVHKIHIRRFYLARNYLEMRVVGGIV-PSHPTLVRAEIIPPKHRLSMARAAVGKGSWLAV-DSWEVTR-KRIMDYMSVLEHAKEVCGDITILYMCQASQVMGFP------------------------------------------------------------------------PTR--------------GCT Entamoeba_dispar_167380300 MEE----------------------------------------------------------------------------------------------------------------NIILVCCGSYNPIHYIHLLLFELTKNYFKENVVKGIISPANDLYWKKGLLSSKHRVAMCQEAVKTSDWII-VDDWESTQ-KEYVRTYNVLAHEREVYNDYDIYFIGADDLIPNMMNKNCWDQVLLEKIVNEFGIVFFKRINPNCSEQIFIIQ-SFQSQHSSTLVRQLVKSGMSIKYLVPDSVINYITEHQLYLE----------EKD Entamoeba_histolytica_67472722 MEE----------------------------------------------------------------------------------------------------------------DIIIVCCGSYNPIHYIHLLLFELTKNYFKENVVKGIISPANDLYWKKGLLSSKHRVAMCQEAVKTSDWII-VDDWESKQ-KEYVRTYNVLKHEREVYNEYDIYFIGADDLIPNMMNKNCWDQVLLEKIVNEFGIVFFKRTNPNCSEQIFIID-SFQSQHSSTLVRQLVKSRMSIKYLVPDEVIYYITQHQLYL-------------E Entamoeba_invadens_471208618 MQS---------------------------------------------------------------------------------------------------------------KSIILVCCGSFNPIHELHLLIFEIAKNYFTLNCYKGIISPANDRYWKNGLLHSSHRVAMCREAVKTSDWIT-VDDWESKQ-TDYVRTYNVLSHEREVYNDYDIYFIGSDDLLPNMADPKCWDPVLLEKLVSEFGVVMLRRLLENPEKEIFVCS-GFQAQHSSTEVRNLVKQGLSIKYMVPDLVIDYIKANKLYL-------------E Escherichia_coli_487633144 MK-----------------------------------------------------------------------------------------------------------------SLQALFGGTFDPVHYGHLKPVETLANLIG--LTRVTIIPNNVPPHRQPEANSVQRKHMLERAIAEKPLFT-LDERELKR-NAPSYTAQTLKEWRQEQPDVPLAFIIGQDSLLTFPT---WY--EYETILDNAHLIVCRRPGYPLEMAIYLAE-TPWFNISATIIRERLQNGESCEDLLPEPVLTYINQQGLY--------------R Firmicutes_bacterium_547821648 M-------------------------------------------------------------------------------------------------------------------KIGIMGGTFNPIHNAHLLIAEMAREEYG--LDRVIFITDGNPP-HSANVTAKQRFEMTHIAIADNSAFE-EDDFEINR-SEKSYTVNTLGYLKEKYPNNDLFFIIGEDSLNDFDK---WY--KPDKILEMCSLLVFPRKSLKSLTEIFPIS-APVFRISSTDIRNRVKNGQTVRYMLPENVRDYINKYHLYKE----------NDR Galdieria_sulphuraria_545709277 MYG------------------------------------------------------------------------------------------------------VYTYTLYRFNGIVLVNCGSFSPITLAHLILMESAYNFAHYQVLGGYLSPVHDSYNKPGLITSRQRLEMCQLAVEDSSWLMV-DSWECC-RSEYSPTFLVVEHFRSQLVNIQLAFVCGSDLYRSLFNSDIWPKNHVERLLDMASLFVIPRMEDLSKSRVFIVDQAPLCQISSTMVRDTLRKGGSIKYMVPDSVYCYIIRHSLYHK----------SVS Gayadomonas_joobiniege_516014004 MSK---------------------------------------------------------------------------------------------------------------YALRLYLGGTFNPIHNGHLHGAIQALESCQ--AEQLFLLPNYLPPHKAPNETAVQRQKLCELSLSIDHRLR-LDDRELQR-SKACYTIETVQILHATY-NEAIGFVIGMDSLQQLAT---WH--QWQQLTDFCHLIVLQRGGYQLELPVFIVD-SPLLEISSSEIRARVKAGLNSTCLLPPAVNQYIIEHDLY-------------ST Giardia_intestinalis_253742205 MT------------------------------------------------------------------------------------------------------------------ALIVFCGSFNPATKAHISIIDRAIDFINNGVYRVLVSPVNDKYPWKKLAPAKDRIKMLKLAIEDSRYQD-VNTYESLIQKDFTPTYDVLCHLKE--PDKNMYFLCGADLVESMTNATVWSVSSIEKIFDICKLLVAPRNLGTGF-KLFF-LPDVSLDCSSSDVREYCADSSKLARYVPFSIMAYIKKHHLYE------------VQ Giardia_lamblia_159108475 MPC---------------------------------------------------------------------------------------------------------------PPVVLVCMGCFDPVTRAHILLVEYAHDWLAHSITRILFSPAHDNYPYKRLAPSIHRVAMLRLAIAESHIMD-VDTGEAEC--QYQPTYAIVENLKQRYDGAQIYIVAGMDLLYSQCDERTWNPANVKRLYSLVSAVIVPRDGGAGGVSRILILNKSVSEISSTAAKEAL-RR--SGTMCVDSVQQYILNNALYSA----------SFQ Gilvimarinus_chinensis_519052214 MR-----------------------------------------------------------------------------------------------------------------RKIAVFGGTFNPIHHGHLRLALDLVQQVG--FDQMRMVPCHIPMHRDPSVASRRRARMVELAIADSPTLT-LDTRELER-GSASYSVDTLAELRAEQEDASIALIMGLDAYQGLMR---WH--RWDELLQLGHLVVVDRPGYQMPASVVHLD-IRALDISATEIRTLTAQGLSTRYLLPETVRRYIAERGLYG------------AG Glycine_max_571506330 MCS------------------------------------------------------------------------------------------------------VVPLPRDKLIYVILVATGSFNPPTFMHLRMFELARDALNSCVIGGYLSPVNDAYKKKGLISAEHRIQLCHLACKSSDFIMV-DPWEAS-QSTYQRTLTVLSRVHNSVESLKVMLLCGSDLLHSFSIPGFWIPDQVKTICKDYGVVCIPREGQDVEKTIKVVNELVPNQISSTRVRDCIARGLSIKYLTADEVIDYIREQQLY-------------LN Hahella_ganghwensis_521078440 MP-----------------------------------------------------------------------------------------------------------------SPLVVLGGTFDPVHHAHLRTALEIQQLLG--NDTVHLMPSGDPRHRAPHASALHRLEMLKLAVSGESRLV-VSDMEVKR-TGATYTVDTLEELRAKEPDRPIIFVMGGDAFLSLPK---WH--RWVEIIRLAHIMVINRPNWSNIGQIAECA-LTQLDISSTQVRTLLKAGQSPRFLIPDLVLDYIRSHHLYGS----------TDA Halomonas_elongata_307544784 MAR---------------------------------------------------------------------------------------------------------------PPRIAMLGGTFDPVHLGHLRSAVELREALA--LDRVHMVPAARSPLRAPQVAPEDRLALLRLGIGDTPGLI-ADAREFSR-RGPSYSADTLAELRDAYSEARLVMALGHDAFMRLAE---WR--EPHRLFELAHVVVIDRPDHEAPLPLLRLL-PSRMAISATEVRRRLARGDSVRYLLPEAVESHVLAQGLYRE----------EGR Halomonas_lutea_517847798 MGM---------------------------------------------------------------------------------------------------------------HARVAMLGGTFDPVHLGHLRSAVELYEALK--LDKVLMVPARVPPHRAPGVSAADRLAMLEAGIGDTSGLV-ADGRELLR-EGPSYSVDTLAQLRVELESARLVMVVGHDAFLKLAE---WH--APERLFDFAHVVVIERPGHAAELPLRLAL-PSRMAISATEVRQRLSDGQSIRYLVPERVESFIQTRNLY--------------R Halomonas_zhanjiangensis_517747105 MSS---------------------------------------------------------------------------------------------------------------PIKIGMLGGTFDPVHHGHLRSALEVREALG--LDRLHMIPAPKPPLRAPQVSAEQRLALLKAGIGDTPGLY-ADDRELRR-EGPSYSIDTLAQLRAEYEQARLVMVIGFDAFLRLHQ---WH--RASDLFSLAHLVVMARPGYQMPWTLTLSL-PSMMAISATYIRQRLREGKSIHYLLPNAVEEAIRKNGFYQH----------HDE Hippea_alviniae_550921245 M-------------------------------------------------------------------------------------------------------------------RIAIFGGTFNPVHIGHIRGAISVYETFK--LDKVIFLPTGIPPHKDNVANAEYRYTMLKLAIEGLKFCE-ISRLEIDS-NRVNYTIDTIGELKKELKEDNLFFVVGTDAFYYLNL---WK--DYKRLVDEITFIVIRRPEYDTKIIVYIYT-PPAFDVSSSMIRRKIRNGECIKYLVPEKVENFIKEKRLY--------------Q Homo_sapiens_18652051 MEN---------------------------------------------------------------------------------------------------------------TEVVLLACGSFNPFTNMHLRLFELAKDYMNGTVVKGIISPVGDAYKKKGLIPAYHRVIMAELATKNSKWVEV-DTWESL-QKEWKETLKVLRHHQEKLAVPKVKLLCGADLLESFAVPNLWKSEDITQIVANYGLICVTRAGNDAQKFIHVVNEWIANDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHNLYSS----------AKT Lamprocystis_purpurea_521993334 M--------------------------------------------------------------------------------------------------------------------IGILGGTFDPIHLGHLRPALDCLESLR--LDQVRFIPNVAV-HRQPEAPATLRLAMLEAAIAGQPEFV-ADTRELER-PGGSFSYDTIQSLRAELMQVPICLLVGGDAFRGFLD---WY--RPREILELAHLVVMHRPGVGRILEILFHE-VTQVDIASTRIRALMRQGLSPRYLVPDPVFDILREAGLYRP----------AEH Legionella_drancourtii_493928026 MH------------------------------------------------------------------------------------------------------------------SIAIFGGTFDPIHNGHLQTSLNIQAHFQ--FDTYIFLPCKIPTIKPAFANNQQRVKMIELAIKDYPTLK-IDLREIER-NTPSYMVETLESFRLEYPEAAITLIMGYDSFISLPH---WY--QWEKLITLANILVINRDEFAKQEIVFLFD-AGHYVISSTAIREEIRLKKDVSLKLPREVCQYIKDEGL---------------Y Leishmania_braziliensis_154335346 MLS-------------------------------------------------------------------------------------------------------YALRTDKLQPVVLVICGSFNPIHNAHLKLYDAAKRSIEGVVLGGFLSPVGDAYGKPGLRCAADRVQVMEKALCHHPELN-VDTWECQQ-PTYTRTFFVLRALEEHVRHVRVVFACGADLFFSFWRPGCWSLCLLRQLLDSFPLVVVQRGGARGNISFTFAAFSVPDDTSSTAVRNAVMELSRLRTMLPEAAIQLVVDLYGE------------LPS Leishmania_infantum_146083652 MPP-------------------------------------------------------------------------------------------------------YALRTDKLQPVVLAICGSFNPIHNAHLKLYDAAKRSIDGVVLGGFLSPVGDAYRKPGLRSAADRLQIMRKALCHHPDLN-VDTWECQQ-PVYTRTFFVLQALEEHVRRVRVVFVCGADLFSSFWIPGCWQLRLLRQLLDSFHLVVVHREGARGCVRFTFATFSAPDDTSSTAVRAAAMELSRLRAMLPEAAVQSVVELYGE------------LTS Leishmania_major_157867676 MPP-------------------------------------------------------------------------------------------------------YALRTDKLQPVVLAICGSFNPIHNAHLKLYDAAKRSVDGVVLGGFLSPVGDAYGKPGLRSAADRVHIMRKALCHHPDLN-VDTWECQQ-PVYMRTFFVLQALEEHIRRVRVAFVCGADLFSSFWIPGCWQLRLLRQLLDSFHLVVVHRDGGRGCVRFTFATFSAPDDTSSTAVRAAAMELSRLRAMLPEAAVQSVVELYGK------------LTS Lepeophtheirus_salmonis_225712656 MSR---------------------------------------------------------------------------------------------------------------INVILLSAGSFNPPTHMHLRMFEIAKDFLHQHVLGGIMSPVHNDYKKESLSEATHRNAMVNLCIKKNPFLKL-STYETS-QDSWTRLKIVLEEHKRLLEPFQILFLCGADLLESFSVPGLWLDDDVEVIVKDFGLVVISREGSNPEKFIHLVTEWITNDISSTKVRRAMRRNESVKYLIPDEVIEYISEHGLYGA----------GKK Loa_loa_312066533 MEK---------------------------------------------------------------------------------------------------------------RRVALLSCGTFSPPTYMHLRMFERARDYLKREVVEGIMSPVADSLGRPDMVPAKHRLKMVELAVKSSSWIKA-DGWECS-QGEWIRTIHVLHHIKEVLCKVQLLLLCGGDVIESITKLMLWNTKQIEEVVRDFGVVVVMRANTDPVSAIFVIDETCPNDISSTRLRTAIRRKESIRYCTSDEVIQYIEDNSLYGAASPDYHDFTLTTV Lottia_gigantea_556108217 MSA---------------------------------------------------------------------------------------------------------------EKVVLLACGSFNPITNMHLRLFELARDSLNKNVIGGIISPVNDKYSKEGLESAKHRCGMIEHALKTSSWIKL-DKWECQ-QDEWLVTAKVLAHHREKLPGVRLKLLCGADLLESFGKPGLWSPQDIEDILQNYGLVCVTRCGTDPSKFIHLVTEWIFNDISATKIRRALRRGESVKYLVQDNVIDYIKKHQLYHV----------PDK Marinobacterium_rhizophilum_522174335 MSS---------------------------------------------------------------------------------------------------------------NEALVFMGGTFDPVHNGHLRTALEIQQWMG--VEQVCLIPSNTPVHRQPGCSPEQRLAMVRLAVEHEPALC-VDAREVLS-EKPSYSLLTLQSLRAEIPDRPLCMVLGMDAYLGLPS---WH--GWEQLTDCCHIIVVCRPGYVYEPDVLMHE-LTPLSISATQIRQLVAKGLSPRYLCPDPVWHYMQQHKLYVI----------EDS Methylomicrobium_alcaliphilum_357405202 --------------------------------------------------------------------------------------------------------------------MIGIYGGTFDPIHFGHLRTALEVKEIFA--LDEIRLIPCFIPPHRSPSAPASMRLRMLELALEDRTNMT-VDTREIDR-GGPSYMVETLMSLRAEI-ERPLLLFIGADAFTGLTA---WY--QWQRLFEFAHVVVMTRPGFNTQT-LFFQS-VTRLEISATAIRQIIAKHRDPGFLLPESVIQYIRQHKLYQ-------------R Methylotenera_mobilis_518740026 M------------------------------------------------------------------------------------------------------------------KTIGIFGGTFNPIHYGHLRMAQELAVGLN--IDSIRFIPSANPPHKTHNISASHRAAMVDLAIANNPLFH-LDDQELKR-TGHSYTIDTLQNLRDELHEVSIILLMGSDAFTQFDT---WH--RWQEIIMLCHIAMVQRPQASKIEPITMRQ-ITALDISSTAIRDAFQHSKSARYLMPDSVIDYIQTHQLY--------------K Methylotenera_sp_519028046 M------------------------------------------------------------------------------------------------------------------QRIGVFGGTFNPIHYGHLRIAQEVAEAFA--LSQVKFLPAAKPPLKEPDVAAKHRAEMVQLAIAANPLFH-LDTRELER-IGLSYTIDTLISLHAE-PQDALCLIVGTDAFARFDQ---WH--RWQSVLEYCHLIVVSRPHGGSLINIAIHD-VTALDISSSQIRGLIRTQKNPAYLCPQAVIGYIQQHGLYR-------------D Meyerozyma_guilliermondii_146423687 MDP-----------------------------SSSIPKNMPIQLADLGSVDAPAHPSISTPSH---DDKSKRHHSK------SAD----IETPPPPSKPTA--PHLYEFPTHRLYPLVIVACGSFSPITYLHLRMFEMALDAITEEVIGGYYSPVSSNYKKQGLADAHHRVRMCELACETSSWLMV-DAWESL-QPKYTRTALVLDHFNEEIRGVKIMLLAGGDLIESMGEPDVWADQDLHHILGKYGCLIVERTGSDVRSFVLVIKQLIYNDISSTKIRLFIRRGMSVQYLLPNSVIRYIQEHKLYFN----------KAD Monosiga_brevicollis_167526969 MAG---------------------------------------------------------------------------------------------------------VGCAVWEPVVLIACGSFSPVTLMHLRLLEDARDTLHAHVIGGYLSPTHDKYGKKTLALGHHRLNMTALAVEDSEWLNV-DVWENA-QSGWTPTALVLDRFERALKPIKVMLTCGADLLDSFETIPLWQPAH-QDIIARNGIVCLERQGTDIDEVIVVFPPAVTNSISSTTVRRQLAQGRSVRYLIPRPVEDYIYRHQLHRL----------WQA Mortierella_verticillata_MVEG_05231 MPP----------------------------------------------------------------------------------------------NLNS--EAEYTFPRERITPLVIVACGSFSPITYLHLRMFEMARDHIVEEIMGGYFSPVSDFYQKAGLAEAKHRVRMCELAVESSTWLMV-DSWESL-QTSYQRTAIVLDHFQNELKPIKIMLLAGGDLVQSFAAPDVWATADLHHIIGKYGCLILERTGSDVYEFVFVIKQLIYNDISSTKIRLFIRRGMSIKYLLPTAVVDYIYAQGLYKH-----------DH Mus_musculus_57527870 MDS---------------------------------------------------------------------------------------------------------------TEVVLLACGSFNPITNMHLRLFELAKDYMHASVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEV-DTWESL-QKEWVETVKVLRYHQEKLGVPKVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICITRAGSDAQKFIHLVNEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHELYNT----------STL Nematostella_vectensis_156405737 MAA---------------------------------------------------------------------------------------------------------------KKVVLLSCGCFNPVTHMHLRLFELARDTLHRTVVEGIFSPAHDAYKKKDLVASQHRLAMCNLAVKTSSWLRV-DDWESK-QDGWSTTKTVLNYMTEQANSCTVKLLCGADLLESFAVPGLWLDSDIESIVKEHGIVVITRHGSNPEEFIHIVTEWIPNEISATKIRCALRRRESIKYLVPDSIIDYIHNNKLYTP----------VKG Neosartorya_fischeri_119470062 MTD----------------------------------------------------------------------------------------------------PPMYTFPEHRLTPLLLVACGSFSPITYLHLRMFEMAADYVKFELIGGYLSPVSDAYRKAGLASAEHRVAMCQLAVDTSNWLMV-DTWEPM-QKEYQPTAVVLDHFDHEIKPVRVALLAGADLIHTMSTPGVWSEKDLDHILGKYGSFIVERSGTDIDEAIYVIQQLIQNDVSSTKIRLFLRREMSVRYLIPVPVIHYIEQHHLYED----------KSG Neurospora_crassa_85086139 MSS--------------------------------------------------------------------------------------------------VTPPTYTFPQAKLTPLVLVACGSFSPITFLHLRMFEMASDFVRFEVCGGYLSPVSDAYKKAGLAPGHHRVEMCSRAVEHSSWLMV-DPFETV-NPAYVPTARVLRHFDHEIRKAKIALLAGADLVMSMGEPGLWSPVDLGVILGEYGAFIIERSGTDIDEAIWVISQVIQNDISSTKVRLFLKKDLSVRYLIPDPVVEYIEEHGLFQD----------QQS Oikopleura_dioica_313242099 MVT-------------------------------------------------------------------------------TR----------------------SSSPTARSKKVTLLQCGSFNPPHYMHLRSQELAKIHLEK-VIAGWMSPVSDGYRKTGLVCSKHRIEMLKSATADSSWI--VSSWEAD-KPEWTPTAEVVKYHVEKSFDAQTYLLLGGDAFASFNIQNLWT--DSVEMIASNGIIVVDRDGSNVQ-IIEVVNPGIVNGLSSTYVRQLLMEKQSIKYLVPEELRKYLEENEIYTA----------TTK Oxalobacteraceae_bacterium_522193879 MV-----------------------------------------------------------------------------------------------------------------YRTALLGGSYDPVHHGHVALGAHFAQLLQ--VDQLRVIPAGLPWQKTLKATPRQRAEMVALAFAGAYDVV-VDLQEIER-GEQTYTIDTLRQVRAELPSASISFLMGADQLQRLDT---WH--EWQALFDYAHICVAARPGFNLATATYLAQ-DFAVDISATEIRAALQRGDSANSLIPPLVLDYIEQHNLY-------------KS Pedobacter_arcticus_515829424 MRH-------------------------------------------------------------------------------------------------------S--NTSFYKLKIGLLFGSFNPIHTGHLIIASYLANHTA--LDKVWLVPHNPLKEKKDLIQVYDRLEMAKLATEDAENIM-VSDIELKL-PQPSYTIDTLTHLRELY-EHEFTLIMGSDNLKSLKK---W--KNYELILRDYKIYVYPRPGYENSELVTITET-PLMELSSTFIRKSISAEKSVKYFLPDEVIAFIESKGLY--------------K Penicillium_chrysogenum_255932279 MAI----------------------------------------------------------------------------------------------------PAMYTFPEYRLTPLLLVACGSFSPITYLHLRMFEMAADHVRFELIGGYLSPVSDAYRKAGLASAEHRVAMCQLAVETSDWLMV-DTWEPT-QKAYQPTAVVLDHFDHEIKPVRIALLAGADLIHTMSTPGVWSEKDLDHILGKYGSFIVERSGTDIDEAIHVIQQLIQNDVSSTKIRLFLRREMSVRYLIPVPVIHYIEQHHLYED----------EGR Perkinsus_marinus_294890669 MPN---------------------------------------------------------------------------------------------------------------RKTVAVIGGSFDPPTLAHLMVASQVVQLG-----EAWMIPCGNRPDKDSQADVVTRLRMTQAAIEAVVPEE-CCDIEVV-NGSFIPTVFLMRRLRE--PDMTFRFVIGSDLPPTLL---EWD--HGDELIAENEFIVLPRPDSKPE-EVTANTALLTTDISSTAARNRLRELGGAVSIIPKQVRA--------------------QSA Physcomitrella_patens_168052241 MSS---------------------------------------MIADWNKVGRPN----------------------------------------------W--LKVMPLPMEKLSRVVLLAPGSFNPPTYMHLRMFELGRDALTAHVLGGYMSPVNDQFHKKGLASADHRIRMCQLAVCDSPTIMV-DSWEAK-QSSYQRTLTVLTRIEAAVEKVRVMLLCGTDLLESLTTPGVWIPDQVRALLQDYGIVCINRNGKDARRLILVVDEIIQNTISATAVRRNLARGLSVKYLIPDSVINHIKMHNLYMN----------QQP Physcomitrella_patens_168052243 MPL-------------------------------------------------------------------------------------------------------------KLSRVVLLAPGSFNPPTYMHLRMFELGRDALTAHVLGGYMSPVNDQFHKKGLASADHRIRMCQLAVCDSPTIMV-DSWEAK-QSSYQRTLTVLTRIEAAVEKVRVMLLCGTDLLESLTTPGVWIPDQVRALLQDYGIVCINRNGKDARRLILVVDEIIQNTISATAVRRNLARGLSVKYLIPDSVINHIKMHNLYMN----------QQP Physcomitrella_patens_168067837 MNA--------------------------------------------------------------------------------------------------------PLPVEKLRRVVILAPGSFNPPTYMHLRMFELGRDALIAHVLGGYMSPVNDLYQKKGLAPAEHRIRMCELAVADSPFIMV-DSWEAK-QNTFQRTLTVMARIDTVVEKVKVMLLCGCDFLESFTTPGVWIPDQVRTLLQEYGIVCVNQDSKDARRLILVVDEVIQNSISATAIRRNLSRGLSVKYLTPDPVINHIKMNHLYTN----------NDE Phytophthora_infestans_301120488 MTR-----------------------------------------------------------------------------------------------------------------EVLLFGLSANPPTGGHMGVVKHCQSM------EIWLLPVYHIYSKRQLAPFEHRVEMCRLALEALKNDGDLKVVEEEREDLRLGSIDLLDYLLD--EDTNFTLLLGGDTYADLLA-GKWK--RGNELMQLVKLLVVDRKGTDSP-RVTYINVPELSDVSSTMVRATADRA-ELARHLDPTVLDYIVQHKLYAF----------ATE Phytophthora_ramorum_JGI_2507661889 MTPLVDI---------------------------------------------------------------------VKDGSK-----------------------VIQY--LKVDVIVLVSSGAYNPIHMLHIRSFYVARQYVESPVVGAFI-PSHDTYVRREMITKRHRLALIETAVASSSWIEV-DKWEITR-RRVLDYLSTLTHVREMCYRFHVMYVCGCNTVVKLSHSALRD--------EGFGCITVCRPTQTDMVITIVELPCDLERATSFRVRQALANACNIEMMVGKPVFQYFVKHEIGDK----------TES Phytophthora_sojae_348676426 LLKLLEI---------------------------------------------------------------------VKDGSK-----------------------VIQY--LKIADSEAPASGAYNPIHMLHIRAFYVARQYVESPVVGAFI-PSHDTYVRREMITKRHRLALIETAVASSSWIEV-DKWEITR-RRVLDYLSTLTHVREMCYRFHVMYVCGCNTVVKLSHSALRD--------EGFGCITVCRPTQTDMVI----TTTIVEDT--GVLPCDL-RATSFRMMVGKPVFQYFMRHEIGEK----------TES Plasmodium_berghei_68063625 MIY---------------------------------------------------------------------------------------------------------------NKKICIYGGSFDPATYGHEMVLSKISNLE-----EIWVVIC-RCRYDKNLEAFEHRNNMFSIMLENNKYPMKVKDLES---ENTTATYDLLNMLKK--PQYEFYFIIGSDLLNDLT---SWD--SGEQLVSENNFIVIERGDFDIN-DIEIPIKSFVNYISSTDVRKLLVKQNDLKKYINSMAINYINNNNLYKS----------YGK Plasmodium_cynomolgi_457873656 MN-----------------------------------------------------------------------------------------------------------------KHVCIYGGSFDPITHAHEMVLAEVSSLD-----EIWVVLC-RCRNDKHLTEFQHRHNMFSLIMNNNSPKMLLKDIECK--ETTTPTYDLLKMQKE--PNYTFYFTIGSDLLNDIF---FWD--NGEELVAENNFIIVERGNYKID-NIKIENMSFINYLSSTDARKILSQKNDLQKYIHPVIINYIKEHDLYDN----------VRQ Plasmodium_falciparum_124513330 MH-----------------------------------------------------------------------------------------------------------------KNICIYGGSFDPITYAHEMVLDKISNLN-----EIWVVIC-RCRNDKSLTEFHHRHNMFTIIINNSSKIIKLKDLESH--SEMTPTYDLLKTQKE--PNYTFYFGLGSDLICDIF---SWD--EGEKLVLENAFIIIERGHFKID-SINIPKLSFINFISSSEARKFLTKENDIKKYIHPLTIDYIIKYNLYD------------FN Plasmodium_knowlesi_193810136 MFN---------------------------------------------------------------------------------------------------------------NKHICIYGGSFDPITHAHEMVLTEVSNLD-----EIWVVIC-RCRDDKHLTEFQHRHNMFSLIMNNNSPKMLLKDIESK--ETTTPTYDLLKMLKE--PNYTFYFTIGSDLLNDIF---SWD--NGEQLVAENKFIIVERGNFKID-NIKIENMSFINYISSTDARKILSEKNDLQKYIHPVIINYIKEHDLYEN----------SST Plasmodium_vivax_156099184 MKV-------------------------------------------------------------------------------G-------------------------------NKHICIYGGSFDPITHAHEMVLAEVSSLD-----EIWVVLC-RCRNDKHLTEFQHRHNMFSLIMNNNSPKMLLKDIECK--ETTTPTYDLLKMQKE--PNYTFYFTIGSDLLNDIF---FWD--NGEKLVAENNFIIVERGNFKID-NIKIENMSFINYISSSDARKMLSQKNDLQKYIHPVIINYIKEHDLYDN----------NSA Plasmodium_yoelii_82752821 MLY---------------------------------------------------------------------------------------------------------------NKKICIYGGSFDPVTYGHEMVLSKISNLK-----EIWVVIC-RCRYDKNLEAFEHRNNMFSIMLENNKYPMEVKDLES---ENTTATYDLLNMLKK--PQYEFYFIIGSDLLNDLT---SWD--SGEQLVSENNFVVIERGDFDIN-DIEIPVKSFVNYISSTDVRKLLVKQNDLKKYINSIAIDYINDNNLYKS----------CGK Polysphondylium_pallidum_281208603 MEK--------------------------------------------------------------------------------------------------YNKLPYQFLTNKLQPVVLISCGSFNPVTFMHLRMFEICKDWCNDEVLGGYLSPVGDAYKKATLIPMKYRCEMLSLALESSEWLNI-DTWEAR-RPEFTPTRQVMDYIHRAVVTVQLKLVAGADLLGTFNVPKLWADQDMDKITSEYGFLCLERTGSDIEDIVKTIKVSITNDVSSTKMRELVKNNKSLKYLTLDPVIEYISSNNLY--------------K Populus_trichocarpa_224123176 MDP-----------------------------------------------------------------------------------------------------------MEKVINVVLVATGSFNPPTFMHLRLFELARDALQSHVIAAYMSPVNDAYKKAGLISGEHRLQMCSLACETSDFVMV-DQWEVN-QSTYQRTLTILQRVESSFESLKVMLVCGSDLLQSFSIPGFWNRDHVRTICSNYGVVCIRREGQDIKKIVKVTDDLVPNQISSTRVRECISRGLSIKYLTADGVIDYIREKGLYL-------------N Porphyridium_purpureum_contig_3419.3 M------------------------------------------------------------------------------------------------------------------PALVLSCGSFSPPTVMHCLMMETARNHAVHRDVIGVVSPVNDAYRKPGLVAATHRVEMLRHALQRSAWVHV-NTWESE-QARFVRSHEVVSHVRAQLASMRVLFVCGTDVAVDILERRGWPEDSVQALLSKAELLIMPRPPSPAAQLIHVLTDAPVANISSTLARRMLRRGYSVKYVLDESVRQYIEEHGLYGR----------AGE Pseudoalteromonas_sp_494620031 M--------------------------------------------------------------------------------------------------------------------IAIFGGTFDPVHLGHINMAQQCVNTFN--LNTLYFMPCALPAHKAPGISTQHRINMLNAAIAPYPHFK-LDLRELNR-AGPSYSLLSLQELRKEHPTTPILFLIGMDSFNNLDK---WF--EWKAITQLCHIVVYQRPAQHCTASLYFLP-GKMLDAASSTIREQLKKSNKKNELLPAAVSHYIEQHQLYQI-----------DA Psychromonas_ingrahamii_119944941 MDI---------------------------------------------------------------------------------------------------------------QQAIGFLGGTFDPIHFGHLRPALEITEALS--LQQLFIMPNHIAPHKASHASARQRSEMVELAISHQARMT-IDKRELKR-HKPSYTIDTLKELKIEY-NTPICFIMGMDSLISFDK---WF--DWKSILSYCHLIISHRPGWQNKFNIYFQA-TSQLAISSTEIRTLLNQDISIDFLTPDSVINYIKEQHLY--------------K Psychromonas_sp_470478781 MPL---------------------------------------------------------------------------------------------------------------QQAIGFLGGTFDPIHFGHLRPALEVCERVN--LQTLFLLPNHIAPHKSAQCSATRRAHMVRLAIKAQPKLR-IDTRELNR-AQASYTIDTLKELKQDY-HTPICFIMGMDSLLSFDS---WH--QWQDILNYCHLIVCHRPGWKCDFNIYFQE-TTQLEVSSSQIRDALQQHRSIDYLLPNSVIDYIKTQQLYKN----------TPD Rhodanobacter_sp_495486361 M------------------------------------------------------------------------------------------------------------------KPLAILGGTFDPVHIGHLNAAWEAAELLD--A-EVRLMPANVPPHRPPVASAEQRVAMLRAALQGQSRLS-LDTRELQR-EGPSYTVDTLVELRAE-GDRPLVLLLGEDAFAGLPS---WH--RWHELFELAHMGVLTRPGVEPTWPVVLMP-ITPLEISATRVRELLGAGWQPRYLLPGGLLDSVALLAPYR-------------R Ricinus_communis_255563474 MDV-----------------------------------------------------------------------------------------------------------MDKVINAVLVATGSFNPPTFMHLRMFELARDALRLRVIAAYMSPVTDAYKKPGLISGQHRLRMCNLACESSDFIMV-DPWEAN-QSSYQRTLTILRRIESFFGSLKVVLVCGSDLLQSFSIPGFWIPEQVRTICREYGVVCIRREGQDIEKTIKIVDELVPNLISSTRIRECISRGLSIKYLTIDGVINYIREQQLYMD----------IEK Saccharomyces_cerevisiae_6323360 MDP-----------------------------PESIPKSIPIILADANSIDAPFIKRKKHHHHHSRKEGNDKKHQH------SSDDDRYGSDSTSETQKYA--PHLYEFPSHRLLPLVIVACGSFSPITYLHLRMFEMALDAISEEVIGGYYSPVSDNYQKQGLAPSYHRVRMCELACETSSWLMV-DAWESL-QPSYTRTAKVLDHFNHEIIGVKIMLLAGGDLIESMGEPNVWADADLHHILGNYGCLIVERTGSDVRSFILIIKQLIYNDISSTKVRLFIRRAMSVQYLLPNSVIRYIQEHRLYVD----------NKE Salpingoeca_sp_326431706 MFA---------------------------------------------------------------------------------------------------------APLECLQPAVLVACGSFSPITNMHLRIFEDARDDLAQDVIGGYVSPTHAKYGKASLASMPDRLNMTQLALQSSSWVNL-SSWECA-QSGWTRTAVVLQHFADELHPVKVMLLCGGDLLDTFDVIPLWLPQD-RETILRNGIVCIERKGTDLQQVIYIIKPQIENDISSSSVRRLLAQGRSIKYLVPDDVIAYIKQHSLHEL----------AQQ Saprolegnia_diclina_530740957 MR-------------------------------------------------------------------------------------------------------------------VLLYGTSANPPCGGHTGIVEFFSSQ------QVWVLPVYHIYSKRNLAPFEHRLNLLRLAFQSLSQP--ACVKETEKSSIRIGSIDIVTHLQA--PDVEFSLLLGADTYNDLIQ-GKWK--GGLRLLDAVRIVVIAREGIALR-PVSYVHVPILDDSSSTQARSATSDD-ELRRLLFPQVLAYIQEHKLYQF-----------AH Scheffersomyces_stipitis_150951341 MDP-----------------------------PSSIPLNMPIQLADLGAVDAPPHPPKNKHAV---VDEFGNYHSK------DVDSQ--DQTVPPPTKSSA--PHLYQFPTHRLYPLVIVACGSFSPITYLHLRMFEMALDAITEEVIGGFYSPVSSNYKKQGLAPAHHRVRMCELACETSSWLMV-DAWESL-QPRYTRTALVLDHFNEEIRGVKIMLLAGGDLIESMGEPDVWADQDLHHILGKYGCLIVERTGSDVRSFVLVIKQLIYNDISSTKIRLFIRRGMSVQYLLPNSVIRYIQQHKLYYD----------NAD Schizochytrium_aggregatum_Schag1_83217 MAR-----------------------------------------------------------------------------------------------------------------------RAFDAERLGV----------------PGRAVAV----------KEVERELCEEAAAA----------AAGT-EPARTGTWDVLQRLRRDHPDVDLVLILGADTLADLRA-GKWKC--GDRILAETDLAVFQRAGFDPI-T------PGLGPHSSTEARRVAEDRPSLHLHVLPEVEAYINEHDLYFA----------GEA Schizosaccharomyces_pombe_429241520 MHT-------------------------------------------------------------------------------NSSGG-------REASLGM--PRLYIFPKHRFIPLVLVACGSFSPITYLHLRMFEMATDTIQEELVAGYFSPVNDHYKKEGLAPAYHRVRMCELACETSSWLMV-DAWESL-QPSYTCTARVLDHFDEEIRPCKIMLLAGGDLIASMGEPGVWSDKDLHHILGKFGCCIVERTGSDVWAFILVIKQLIYNDISSTKVRLFIRRGMSIRYLLPNSVIQYIERYALYRD----------MEP Selaginella_moellendorffii_302756067 --------------------------------------------------------------------------------------------------------------------VILVATGSFNPPTIMHLRMFELARNRLMSSVLGGYMSPVHDGYAKPGLALAEHRIQMCQISTADSPFIMV-DSWEAR-QPTRQRTVDVLARVDHCIGTVRIMLLCGVDLLATLEDASIWIPDHVERICRDYGIVCLSRDGQSIDKVQQKITLLSLKSLVFFLRRQSFERALSVKYLVHDGVIEYVKSHRLYN-----------YRE Sorghum_bicolor_242066962 MEE-------------------------------------------------------------------------------------------------------VPLPREKLGGVVLVATGSFNPPTYMHLRMFELAKDELEQSVLGGYMSPVNDAYKKKDLLPAAHRIRFCELACKSSSFVMV-DPWEAM-QKGYQRTLTVLSRVRNSLGSLKVMLLCGSDLLESFSTPGVWIPDQVRTICKDFGVICIRREGKDVGTMIISVDEIVPNQISSSRVRDCIRRCLSIKYLTSDEVIEYIREHKLFME----------TTL Spiribacter_sp_554595317 ---------------------------------------------------------------------------------------------------------------------MALLGGTFDPVHYGHLRPAVELLEALC--LAEIRLVPGHVPPHRQPRLDAPARAGLLDTAVAGIPGLV-VDRCELDR-PGPSYTVDTLEHLRRSLDQRPLCFIMGWDAFRGLMR---WH--QWQRLAALAHLVVVTRGGDTQALAVLFQA-VSRLEISATGIRRCLALGYSAQGLMPDAVWHELALRGCYGY----------RHV Spironucleus_salmonicida_558601652 M-------------------------------------------------------------------------------------------------------------------SVLLLPGSLNPITKAHIASLELAYNTLKNSIDKLIISPANSNYKQKHLVSGTHRVAMANLAIKNSHLFI-VDDFEALE--NFVPTFQLVNHLSKKY-NKKVILVGGSDLLLGMMNQNIWPEVNVRKLLNQCDLFIISRGVSVQSL-SIILIEESVGKESSTLFRA----G--CLDCCFDNVVQYAHTHQLYSF----------SEK Spizellomyces_punctatus_SPPG_01224 MSS-------------------------------------------------------------------------------------------------A--PHPYVFPKDKLIPLVIVACGSYSPVTNLHLRMFEMARDYINDCLLGGYFSPVSDAYNKPGLAAWNHRVRMCELAVADSDWLMV-DPWESR-QPEYQRTAWVLDHFDRMLPRIHIMLLAGGDLIQSFAVPNLWKESDLDHIIGDFGCLIIERSGADLTEFIHLIQQHINNDISSTKIRLFVKRRLSIKYLLPDSVVKYIGEQGLY--------------Q Strongylocentrotus_purpuratus_390336005 MPG------------------------------------------------------------------------------------------------------INSTPCTKCTRVLLLACGSYNPITNMHLRMFEIARDYLHHQVIGGVLSPVNDGYKKQSLISSKHRIEMCKMAVENSDWLKV-DTWEAE-QPNWLTTVKVLTHFDSELLGVEVKLLCGADLLESFAVPDLWDKEDLETIVGKHGLVVITRSGSDPYKFIHIVTEWISNEISSTKIRTALRRDKSVKYLIPEPVVKYVKENGLYKE----------KNK Tetrahymena_thermophila_146165677 MEK---------------------------------------------------------------------------------------------------------------QKRIGILGGTFDPPTLSHIEIAKQSLLQH-----EVWIVPCGLRTDKITQTEPKHRLEMVSIAVKEVIEQNLTNDIEVK-NNRTIPTYPLMKRFEK--PEYDFYFLMGYDLIKGLL---SWD--QGQELVNEIKFIIAGQPNLEWK-FKLI---KIYENVRSTNYRKIIVESYLEAGLLSQNIINYIIQNNLYVQ-----------QI Theileria_annulata_65303484 MSA---------------------------------------------------------------------------------------------------------------MTNVLLFCGAFDPITTGHMIMLDLCIKTNF--FSEIRIMPSGKRTDKQYKVTDEHRTEMCKIAIDLFVNIS-ISDYELNL--KNVDTYFTMKHFNETETDKNFYFFMGSDILPQMFD---WL--VSHELIKIAHFLIAYREDFKIKQEEDQNQQTQTSSASSTEARNNL-NGHVIHNTIL---SSYILNL----------------VM Theileria_parva_71026135 MNA---------------------------------------------------------------------------------------------------------------VTNVLLFCGAFDPITTGHMIMLDLCIKTNF--FSEIRILPSGKREDKQYKAKDEDRTKMCQIAMDLFLKIN-ISDYELKL--NYVDTYFTLKHFNDTEPEKSFYFFMGSDLLPQMFD---WP--HSDNLVNIAHFLIAYREDFEIKQEWKNGQKTQTSPASSTQVRDTL-HGHKCGNLLHPDVMKYVEENKLYDY----------VVS Trichomonas_vaginalis_154423037 MTS---------------------------------------------------------------------------------------------------------------EEIVLAFCGSFNPPTNGHLMAATIARDHMTDNVKATVFVPAHSGYIKPGILSGEQRAEMLEAMVAHTDYLSV-DRFEVQ-KNDWTRTIDTLLYLREKH-KCRIVLIVGIDIVESFET--KWREPDVKRILEEFGLCILPRVTEAVD--LYVVGSNPLNLVSSTLVRDEIKKGHHIVGLVDPAVAEIIAKNNYYK-------------D Trichoplax_adhaerens_196009472 MAS---------------------------------------------------------------------------------------------------------------SPLILLACGSFNPITHMHLRLFENARDAMNANVKAGIVSPVHDSYKKEGLISSKHRLEMCNIALQTSDWIRC-NDWECR-RSEWSRTVEVLRYIKSISQDVGVKLLCGADLLESFATPNLWSTDDLQEIVEKFGLVCITRHGSDPRKFIHIVTEWIPNEISSTCIRRALRRQQSIKYLVPDSVADYIYKHSLYS-----------TVH Trypanosoma_brucei_72389282 MLL----------------------------------------------------------------------------------------------------FLLYRFFASKLCLVVAALCGSFNPMHKTHVEMYNLVEEVLKGLLVGGFVSPVNDGYEKEGLHSFEERVAVCDASLAGHPALS-VDRWEGLQ-PDFVNTFWVLDHIQRQVHPVRVLFVCGSDLSATFLIPGVWELPLLKRLLDNFGIVVYRRPGTPSWKESIIETDLLNSFISATDIRKQLLMEADLTAFVIPTAEELIRKFYGKE-----------SIS Trypanosoma_congolense_342181069 MTY-----------------------------------------------------------------------------------------------------------GSKLNIAVAVICGSFNPMHQAHIDMYNVVGDVLKELLVGGFVSPVNDRYEKEGLHSFTERAAVCEASLVNHPALS-VDRWEGLQ-PKYVYTVFVLEHMQQEVHPVLTIFVCGSDLFSSFLIPNCWQLPLLERLLDNFDVLVLRRSGTSGCKESFIESELLSSPITSTDIRERLLRDTDLVSLVPPTAIDLVRAYYGRG-----------ATQ Trypanosoma_cruzi_407838812 MSD-------------------------------------------------------------------------------------------------------YRFSGLKLRLALVAMCGSFNPIHLAHIAMYDAARDALMHVVVGGFFSPVNDHYGKEGLRPFAQRAAICKAALADHPSLA-VDEWEGLQ-PMYVRTVYVLDHLQKAAHPVSVVFVCGSDLFASFLRPGCWSLKLLKQLLDNFDVMVVRRACTNVGCERFMEVEIFANETSSSAVREALAADADISNLVPAGADSLIRAFYANN-----------QNC Ustilago_maydis_71024819 MPR----GGDEAGKHSDPHRSNDSNGHLESRFSLALSPDKPIMSTETSAVDRPGRRSDDTGSNNSTSNSRTLSFSA------DAEDA------ADEEPEGA--DRQYSFPRHRLTPLVVVACGSFSPPTYLHMRIFEMAKDQIIEELLAGYYSPVSDYYKKEGLAKATHRVRMCELAVETSTWLMV-DAWESL-QDEYQRTAVVLDHFHDEIKNVKIMLLAGGDLIQSMGEPGVWATADLHHILGQYGCLIVERTGADVWSFLKIVKQTIYNDISSSKIRLFVRRGQSIKYLLPNSVIQYIEKEGLYRL----------ANW Veillonella_parvula_490831099 MVD---------------------------------------------------------------------------------------------------------------KRRIGIIGGTFNPIHLGHLMIAEVACESFN--LEKVIFVPARIPPHKHDVIDSHHRYAMTAAAVSDNPNFE-ISDVEMRR-EGPSYTVDTIQYFKKLYPTVEFYFIAGTDTIRALPT---WK--FIDELIDEVHFIGATRPDGSSAIDIHVME-VPEMKLSATYLRERLRSGKTVRYMLPKCVVDYIEENHIYG------------KE Vitis_vinifera_296089926 MDI-----------------------------------------------------------------------------------------------------------LEKLMYVALVATGSFNPPTNMHLRMFELARDALRSCVIGGYMSPVNDAYKKRGLISAEHRIQMCDLACKSSEFIMV-DPWEAN-QSTFQRTLTVLSRIKCSLESLKVMLVCGSDLLESFGIPGFWITEQVMAICRDYGVVCIRREGQDVEKIIIVVDDLVPNQISSTRVRECISRQLSVKYLMEDRVIDYIKRHHLYSN----------SER Volvox_carteri_302828098 MFG------------------------------------------------------------------------------------------------------HAALPTEKLTPLVLVCCGSFNPPTIMHMRMVDLAGDELMRDVWAAYLSPVADAYGKAGLAPAADRVAMCRLAAEASASGQV-YDWEAR-QPGYTRTLAVLRRPH---PPVRAMLLCGGDVLASMAVPGVWRDPDV--ILREHGVVCVAREGTDLEKLILVVYDRVGNSISSSKVREELAAGRPVRYLVPQSVLSYIYEKGLYGT----------VDN Xanthomonas_oryzae_188577783 M----------------------------------------------------------------------------------------------------------------------------------HLV----PA---------------ADPPHRAPGATAAQRAQMLQLALSDYPGLQ-LDTRELQR-DAPSYTVDTLRALRAELSAAPIAWLLGADAFVGLDH---WH--AWQALFGLAHFVVAARPGTTLELALYLLH-QPLRGESASAVRSRIATGAEWQALVSPPVAAMIQREGLYRS----------PAS Xenorhabdus_bovienii_290476194 MLH---------------------------------------------------------------------------------------------------------------PIIQALFGGTFDPIHYGHLRPVEALAKQVG--LKQVILLPNHVPPHRQPEATASQRLEMVRLAVQDNPLFT-VDTRELER-QTPSYTIETLKSFRQEVEQRPLAFIIGQDSLQSIHT---WY--KWEELLGICHLLVCSRPGYQSQLSIYLAT-TPLLNISATDIRQRHQQGLSCDDLLPPAIQNYVNSQGLYR-------------Q uncultured_bacterium_406979593 MQI----------------------------------------------------------------------------------------------------------------QPIGIFGGTFDPIHFGHIHLANKMLQLCN--LQKIILIPCSQSPLRQPIASTEDRLNMAMLAIEGMAHFF-TDNREIKR-AGISYAIETLKSLRQEN-NTPLALIMATDVFNRFDE---WH--EWQKILDFTHLLIAKRPEVGQITNIYLAN-INPLPITATEIRALIKQQKDASHLVAPDVWQYICKNHLY--------------I uncultured_bacterium_406999011 MP-----------------------------------------------------------------------------------------------------------------EPLGLFGGTFDPIHFGHLRLAEEAIAHLG--LAGVRWIPAGQPPHRQPEVTGKQRLEMVLRSTAENARFF-VDASEVEA-AAPSYTVNTLERLRDELAEQSLVLLVGADAFAGLST---WH--RWQDIFALAHIAVSHRPGFPIEISIVSFA-MTQLAISATQIRKLLANGLSARYLLPDSVLDYIQRHQLYRN-----------RL ; END;