#NEXUS
[!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file.


Generated on September 18, 2025; 21:25 GMT

TreeBASE (cc) 1994-2008

Study reference:
Ternes C.M., & Schoenknecht G. 2014. Gene transfers shaped the evolution of de novo
NAD+ biosynthesis in eukaryotes. Genome Biology and Evolution, .

TreeBASE Study URI:  http://purl.org/phylo/treebase/phylows/study/TB2:S15669]

BEGIN TAXA;
        TITLE  Taxa;
        DIMENSIONS NTAX=166;
        TAXLABELS
            Acanthamoeba_castellanii_470517218
            Actinomadura_madurae_545320345
            Aequorivita_sublithincola_390953239
            Algoriphagus_sp_495473647
            Allomyces_macrogynus_AMAG_10324.2
            Angomonas_deanei_537372006
            Anolis_carolinensis_327260646
            Aplanochytrium_kerguelense_Aplke1_103472
            Aplysia_californica_524905774
            Arthroderma_otae_296821370
            Ascaris_suum_541046725
            Ashbya_gossypii_302309262
            Aspergillus_oryzae_169771699
            Aspergillus_oryzae_169783496
            Aurantiochytrium_limacinum_Aurli1_123094
            Aureococcus_anophagefferens_323447713
            Batrachochytrium_dendrobatidis_328769415
            Belliella_baltica_390942403
            Bigelowiella_natans_Bigna1_85246
            Bos_taurus_194664679
            Branchiostoma_floridae_260797831
            Caenorhabditis_briggsae_268579665
            Caenorhabditis_elegans_17550466
            Canis_familiaris_73984361
            Capitella_teleta_443720978
            Catelliglobosispora_koreensis_522009671
            Cecembia_lonarensis_496477197
            Cellulophaga_lytica_325285513
            Chondrus_crispus_546309105
            Coccidioides_immitis_119188619
            Colletotrichum_graminicola_310789744
            Colletotrichum_graminicola_310801791
            Corallococcus_coralloides_383452884
            Crassostrea_gigas_405951390
            Cryptococcus_neoformans_134109429
            Cyanidioschyzon_merolae_544210763
            Cyclobacteriaceae_bacterium_499127132
            Cyclobacterium_marinum_343084375
            Cyclobacterium_qasimii_527059814
            Cystobacter_fuscus_488704730
            Danio_rerio_292614504
            Debaryomyces_hansenii_50427091
            Dictyostelium_discoideum_66809835
            Dictyostelium_fasciculatum_470250369
            Dictyostelium_purpureum_330791259
            Dyella_ginsengisoli_516032247
            Echinicola_pacifica_517283863
            Emiliania_huxleyi_551569804
            Fibrella_aestuarina_436836127
            Fibrisoma_limi_496583666
            Fischerella_sp_515877336
            Flavobacteria_bacterium_496143392
            Flavobacteriaceae_bacterium_498208272
            Flavobacteriaceae_bacterium_518217641
            Flavobacterium_branchiophilum_347535574
            Flavobacterium_sp_518925889
            Flexibacter_litoralis_392395752
            Flexithrix_dorotheae_522021427
            Fluviicola_taffensis_327403597
            Formosa_sp_494924573
            Frankia_sp_312195122
            Frankia_sp_494780408
            Frateuria_aurantia_383317264
            Galbibacter_sp_496280101
            Galdieria_sulphuraria_545701317
            Gallus_gallus_50750794
            Gillisia_limnaea_494047587
            Gillisia_sp_497918210
            Gloeophyllum_trabeum_521728065
            Herpetomonas_muscarum_537372252
            Homo_sapiens_4504937
            Indibacter_alkaliphilus_496323979
            Kangiella_aquimarina_517452498
            Kangiella_koreensis_256821602
            Komagataella_pastoris_254571213
            Kribbella_catacumbae_521053707
            Kribbella_flavida_284033374
            Krokinobacter_sp_332292562
            Laccaria_bicolor_170088266
            Leeuwenhoekiella_blandensis_497467124
            Leishmania_braziliensis_154339509
            Leishmania_major_157871361
            Lewinella_cohaerens_522027717
            Lewinella_persica_522055487
            Loa_loa_312091865
            Magnaporthe_oryzae_39944710
            Maribacter_sp_305664463
            Marivirga_tractuosa_313676925
            Maylandia_zebra_499025258
            Micromonospora_lupini_494728308
            Micromonospora_sp_315504130
            Mixia_osmundae_358059419
            Monodelphis_domestica_126326297
            Monosiga_brevicollis_167525551
            Mortierella_verticillata_MVEG_00226.1
            Mucilaginibacter_paludis_495786261
            Mucor_circinelloides_511001590
            Mus_musculus_27229113
            Myroides_injenensis_497935495
            Myroides_odoratimimus_493308872
            Myroides_odoratus_489080158
            Myxococcus_fulvus_338530492
            Myxococcus_stipitatus_442317947
            Naegleria_gruberi_290998277
            Nectria_haematococca_302885551
            Neurospora_crassa_85091828
            Niastella_koreensis_375147778
            Ogataea_parapolymorpha_320580640
            Oryctolagus_cuniculus_291391520
            Oryzias_latipes_432849856
            Owenweeksia_hongkongensis_375012446
            Pedobacter_agri_498287270
            Pedobacter_sp_495513657
            Phaeosphaeria_nodorum_169610557
            Polaribacter_sp_472323014
            Polysphondylium_pallidum_281206095
            Porphyridium_purpureum_contig_3401.26
            Pseudoxanthomonas_suwonensis_319787284
            Psychroflexus_torquis_408492022
            Psychroflexus_tropicus_517869370
            Puccinia_graminis_309316393
            Rhizoctonia_solani_471916975
            Rhizophagus_irregularis_552911183
            Rhodanobacter_fulvus_494142171
            Robiginitalea_biformata_260063638
            Rudaea_cellulosilytica_517804387
            Rudanella_lutea_518832048
            Runella_slithyformis_338211507
            Saccharomyces_cerevisiae_323353801
            Saccoglossus_kowalevskii_291244130
            Salinispora_arenicola_519061563
            Salinispora_pacifica_517063272
            Salpingoeca_rosetta_PTSG_00703.1
            Saprospira_grandis_488736761
            Schizochytrium_aggregatum_Schag1_94483
            Schizophyllum_commune_302692670
            Shewanella_woodyi_170725766
            Solitalea_canadensis_387790622
            Sphaeroforma_arctica_SARC_07149.1
            Spirosoma_linguale_284036437
            Spirosoma_luteum_517450591
            Spirosoma_panaciterrae_522087298
            Spirosoma_spitsbergense_522093455
            Spizellomyces_punctatus_SPPG_08715.3
            Stenotrophomonas_maltophilia_194366371
            Stenotrophomonas_maltophilia_515924642
            Stigmatella_aurantiaca_310819994
            Streptomyces_scabiei_290956051
            Strigomonas_oncopelti_537372148
            Strongylocentrotus_purpuratus_390346745
            Talaromyces_marneffei_212538249
            Thecamonas_trahens_AMSG_00747.2
            Trametes_versicolor_392566839
            Trichinella_spiralis_339245045
            Trichoplax_adhaerens_Triad1_28018
            Trichosporon_asahii_406700278
            Trypanosoma_brucei_71744026
            Trypanosoma_cruzi_71409561
            Verrucosispora_maris_330469682
            Winogradskyella_psychrotolerans_527071721
            Xanthomonas_albilineans_285018529
            Xanthomonas_arboricola_515423494
            Xanthomonas_fragariae_488893332
            Xanthomonas_oryzae_84623962
            Xenopus_tropicalis_301615894
            Yarrowia_lipolytica_50547545
            ;
END;

BEGIN CHARACTERS;
[! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M21791]

	TITLE Kynureninase_Alignment;
	LINK TAXA = Taxa;
	DIMENSIONS NCHAR=428;
	FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -;

MATRIX
[                                                     10        20        30        40        50        60        70        80        90        100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370       380       390       400       410       420        ]
[                                                      .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .        ]
Acanthamoeba_castellanii_470517218            MQQAGEKA-S-LTLDRRDPLAAMRDRFLFPLADDSGP------------YFCGNSLGLQPARARRYVLYELDEWHKRGVEGH-EGKKPWLTTDEN-HARAAGLVGAL-LEVAIMNGLTVNLHLMM-PFYRPTAQRHKILIEGRSFPSDWYAVETQIRFH----EPSTSLIQP-E-ET-LRTEDIIA-IEKEGDSIALVLLSGVQYYTGQFFEIEKITAAG-SK-CVVGWDLAHAVGNVVLKLHEWGVDWACWCSYKYLNSGPGGIAG-FVHERH-HR-DLFGGWWGHTIKTRFDMNQPFDP--GAF-FRLSNP-VLQ-CTLFASLEVFEE--MEKLRAKSVLLTAYLEMLLLE-LAIH-FTPREVAQRGCQLSVKFSV-VER-VHEKLQKGVIVDVRKPDVIRIAPAPLYNSFSDVLRFVTLLAQAIE
Actinomadura_madurae_545320345                ---MSE---E--RLDETDPLPTLRG-FLVPPA----PGGTY-----EEAYFAGNSLGLQPRSVAGRLREELDDWARLAVEAHTRGRRPWVDYHE----LA-RLVGARP-EVVAMNSLTVNLHLLMASFYRPAGRRTRIVIEDTAFPSDSYAVASQAVHHGLDPDATVVRLRPRDGEDNLRTEDVLARLEREGDTIALVLLGGVNYLTGQLMDMAAITKAGRAAGAVVGWDLAHAAGNVPLRLHDWDADFAAWCTYKYLNGGPGAVAGCFVHERHVRDAPKLQGWWGTDPAVRFRMD---PCPPASDAWQLSNPPIMALAPVLASLEIFDRVGMDALR-KSERLTGYLASRL--A---ETITPADPAARGAQLSLR--V-D-G-LVRALRHGVIADAREPDIVRLAPVPLYCTFHDCHRAA-ALADLAG
Aequorivita_sublithincola_390953239           MQNI-E------R-DAEDSLASFRNKFHIPK-ND---------F-GEEVYLCGNSLGLQPKITSEYIQEVLNDWAKFGVEGHTEAKNAWLPYHEFLAEN---IVGAKP-EVVVMNTLTTNLHLMMVSFYQPTKTKYKIVVESDAFPSDKYAVESQLKFHGVDIKDAL-LWKPRKGEELCRFEDLEE-MKQHGNEIALLMIGSTNYYTGQSFPLKKITELGHKYKCMVGFDLAHGAGNIQPNLHETGADFAVWCTYKYLNSGPGSLGGCFVHERHANN-NRFAGWWGHNKKTRFNMRKDFDALPGAEGWQLSNPPILSMAAIRASLDTFAEAGFENIRKKSEKLTGYLEFLL-EMN-INVITPRNPEERGCQLSI--QVKNAD-LHTKLEAGVISDWREPDVIRIAPAPLYNSFEDVFKFSEK-KE-LK
Algoriphagus_sp_495473647                     -------M-YQFKMD-DDPLAKFRDQFYFPKV-----------N-GKQIYFCGNSLGLQPKTVKSYLDKELSNWENLAVDGHFHGEDAW-Y-RKKS-PALAEIVGAHT-EVVAMNNLSSNLHFLMVSFYQPTEKRNKILVEAGAFPSDQYMLETQVKFHGLDPESTIIELKPRAGEHNLRTEDILAKIHELGDSLAVVNMAGLQYYTGQLFDIKAITNAAHAVGAYAGFDLAHAAGNASLKLHDWDVDFATWCSYKYMNSGPGNISGIFVHERFAE--P-LAGWWGHDEGQRFLME-KFI--PGADGWQVANSNVLALAA-HASLDIFQEAGMEKLLAKSEKLTGYLEYLI--K-GLEIITPKDPAERGCQLSLHIHRGGKA-VFDEWSQGVVGDWRNPNVIRLAPTPLYNSFMDVFSFGLI-EQSLK
Allomyces_macrogynus_AMAG_10324.2             ---MA-TTP-QFALDAADPLRALRNDFLLPAY-PAPAAGTAAA-ADK-VYLCGNSLGLQPRGTRDLLMQELDVWANRGVMGHP-G--PWAEIDET-TGE---IVGAN-NEVAVMGTLTNNLHLLM-AFYRPTQQRYKILIEGKAFPSDQYAVASQVQVH----KDAVIALT--E-EATLRTEDILA-IKQHGNEIAVVLFSGVQYYTGQLFDMPTITRAA-EA-CVVGWDLAHAVGNVPLHLHDWDVDFAAWCTYKYLNSGPGCIAG-FVHAKHADMDPRFAGWWGHDKQSRFKMPDQFAP-PGAA-FQLSNPSVVATV-LLGSMQVFQK-SIAQLRAKSLRLTAYLE-LIVSEIS-RILTPSDPNQRGAQLSLLFA-MNGP-LMKELHRGVVVDEREPNVIRVAPAPIYNNFTDVRRFV-ALKESL-
Angomonas_deanei_537372006                    -QNPSSGLL-AF-RDEIDVLNEHRQSYHFPK-QP---------S-A-P-YLVGNSLGLQHVGVRTAVDEFLQKWQDQAVEGHFMQPNPW-EI--ILRA-MAKIVGADRREVVLMNTLTVNIHFMMAAFYRPEGKRKKILMENQGFPSDTHALISQLQLHGYG-EDL-TVSA---GEE-VTTEAFIAAIEQHADEIAIVMITAIHFLTGQLFDIPAIVKAAHAHNIVVGVDCAHAVGNVPLQLHDWDVDFACWCTYKYLNSGPGNVGGAFVHSKHTDS--YLKGWWGHDRKSRFSLHREFE--DGA---------TSSLT-LQPSLQLMASIGM-KLREKSLHLTAYMEL-L--E-G--SVTPADPEQRGAQLSIRI-L---TCIAQQLDCGVMV-NRPPDIIRLAPAPLYNSYMDVLQAVRVFA-LF-
Anolis_carolinensis_327260646                 M----------V--DEEDELKYLQERFHIPKVKDLPPTNPALVKENDNIYFAGNSLGLQPKKIK-YLDEELDKWAKMGVHGHFNGK-PWALG-ECI---MA-IVGAHKDEIALMNGLTVNLHLLMLSFFKPTSDRYKIFLEAKAFPSDHYAIESQLQCH----EKCMLMIE--K-EE-LRTE-ILAVIEKEGDSIAVILFSGVQYYTGQLFDITKI--AG-AKGCFVGFDLAHAVGNVELHLHDWGIDFACWCSYKYLNSGAGGLAG-YIHRKH-QTVPALIGWWGHEFQSRFLMENKLQLSPGINGFRLSNPPILLVCSLHASLEIFNQTTMKLLRKKSVLLTGYLEYL-KQHF-VKIITPSNIGERGCQLTLTFSIPIKP-LFKELKRGVACDMREPNALRVAPVPLYNSFCDVHTFIEIL----Q
Aplanochytrium_kerguelense_Aplke1_103472      -----------IELDENDELSKFRQDFLFPKVNTAPK--FAVKSHGEEIYLCGNSLGLQPKRTR-YVQEELDKWAECGVEGH-FTK-PWVTI-ELC-NTMA-IVGAKPIEVAIMNSLTVNLHLMMTTFYRPNAQRFKIIIEGKAFPSDVIAVESQIREK----DDALVKIA--E-EN-LRTE-IIEAIREHRDNLALVLLGGLQYYTGQAFQMESV--AIIA--KF-GVDLAHAVGNMELHLHDWGVDFACWCTYKYLNSGPGSIGG-FVHERY-HKGE-LAGWWGHRKSDRFDMAETF--IPGAFGWQLSNPPVLPLAALRASLEIFDEAGMANLRNKSINLTRYLEVL--HPQ-CKVITPGFYQERGCQLSLTFSIA-EK-VHSIIREGVVCDLRKPNVMRIAPCPLYNSYVDVFDFVKILA---E
Aplysia_californica_524905774                 M----EGLM--F--DSRDPL---RDEFHYPKMSDVLNTDLSLVDPSADVYFCGNSLGLCPKKTK-YMDVQIDKWAKMGVQGHTNGE-PWAWC-ECL---MTKIVGCNREEISIMNGLTVNLHLLLISFYRPTKDRYKILCESKAFPSDHYAFESQSKLH----EDVMICVE--E-EY-IRTE-ILAVIEREGDKIAVVCFAGVQYYTGQLFDIPTI--AG-AKGCYVGWDLAHAAGNVPLYLHDWNVDFACWCSYKYLCASAGGLAG-FIHEKH-SNDPKLLGWWGHDLSSRFVMDNNMDLIPGARGYRVSNTPGFLCVPLKASLEIFSKTSMEELRKKSLLLTGYLEAL-RRSYQIDIFTPHDPQQRGAQLSLAFNVCIEE-LFKELKRGVVCDKRLPRVIRISPSPMYCSFLDVHRFMGYLRDALN
Arthroderma_otae_296821370                    -----DSKP--Y-LDELDPLRSFRDEFIIPSKADL--VRTTLVSE-ESIYLCGNSLGLQPTSTSAHVNSYLRSWAL-GVLGHQLS---W-NI--RAAE-MAPLVGAKTSEVALMGTLTGNLHLLMASFYKPTKERYKIIFEGKAFPSDHFAFESQAHHHGLDSADT-VLIEP-S-EELL--SHILSVIDAHADTAALILLPGIQYYTGQFFDMETITAYAHSKGLMVGWDCAHAVGNVELKLHDWDVDFAAWCSYKYLNSGAGAMAGLFVHEKHGKV-GR-SGWWGSDKSSRFIMDNR-EFRPGA---------ALDLA-VTASLKVFNKASM-ALRRKSVHLTAYLEY-I-SEFPFTIITPSDPDMRGAQLSLLLR--G-D-------NGVVLDERRPDVLRVAPAPLYNSFEDVWLFVRELRVAC-
Ascaris_suum_541046725                        MD---------EVLDKRDPLRHLRDEFYYPKMKTIPRVDYSLVNEDDDIYMCGNSLGLMLKSTR-YMDIQFEKWANMGVCGHTEEPLPWAHC-EAV-E-AK-LVGAEPSEVALMNGLTVNLHIFLAAFYKPTKNRHKILLESRAFPSDHYAIESQIRLK----EDSMVCVE--K-ED-LRNE-ILSVIEREGDSIAIIMFSGLQYYTGQLFDIEAI--AG-KKGCIVGWNLAHAFANVPLSLHEWNVDFACWCTYKYGSSSAGGLAG-FIHSKY-SDKERMLGWWAHKASTRFIMDNKLELDDGAA-YRISNPPMMLVVPLQAFLEVMSKTSLEELRKKSILLTGYLEFL-NHHL-CSIMTPSDPRQRGCQLSLKFNVDIVK-VFEELKRGVVVDKRYPNVIRVTPVHLYNSFRDVHRFVELLD---D
Ashbya_gossypii_302309262                     MEK--------A----EEQWPGARDAFHVPSYASL---GLG----D--RYLCGHSLGCMPRKTRGSVEAELSAWSARAVE-----RHEWVNTDLP-VPQMARMVGAS-QEVAVMGSLTANLNALL-AFYRPRGRRTKILLEKQVFPSDFHAFWNQAALH----AATLVQVAPRA-EH-LRTEDIVA-IETHRAELALVCLPGVQYYTGQLLDMASIV-AA-RESIVVGFDLAHAVGNVQLQLHEWGADFACWCSYKYLNAGPGGIAG-FVHERHH-T-PRLAGWWGTNAATRFEMRQTYDP-PDALGFRQSNP-VLDVA-LRASLEVFEDGGME--RARSLALTGYLYE--TQSYRFTILTPANP-ERGAQLSLLFSDDDKN-VFADLQ-GVLGDERHPDVIRLTPCALYNTFMEVFESVQLLNAALE
Aspergillus_oryzae_169771699                  -S---S-VPE-Y-LDAADPLASFRDKFIIPSKANIN-KKLAKLSSD--IYFCGNSLGIQPKATAKYLEAQLDTWSSIGVSGH-VDSPQWQLS--AAAS-SK-IVGAQAEEVAAMGTLTANLHLLLASFYKPTPTKHKILLDWKAFPSDHYAIESHLAWHNLDPKQS-VLIGP-EGEYEISTEKILSYIDEHAESAALILLPGIQYYTGQLFDIQKITAYAQSRDLTVGWDLAHAYGNVELKLHDWDVDFAAWCTYKYGNAGPGAMGGLFVHERHGRVF-R-TGWYGGDRSVRFKMDNN-KPIPGA---------AIDL-CLCASLSVFDETSM-ELRKKSVMLTAYLEH-LKDTTDFRIVTPADPEARGAQLSVLL-K-G-N-------GGIVCDKREPGVVRVAPTPLYNTFTDVWKFVSYFKAA--
Aspergillus_oryzae_169783496                  -S---EKKPDIA-LDAQDPLRHFRDEFIIPSKKDLK-KTL---NA-ENIYLCGNSLGLQPRNTRKYLEHYLRTWAI-GVTGHQL----F-DV--A-GA-MAPIVGALESEVAVMGTLTANLHFLMASFYQPTKEKYKIILEGKAFPSDHYAVESQIQHHNLDPKDA-VLIE----LE-LPIEKILRVIDEHASSTALILLSGIQFYTGQYFDIEKITAYAHSKGIIIGWDCAHAAGNVELKLHDWNVDFAAWCNYKYLNSGPGGMAGLFVHENHGRV-PR-SGWWGDDKKTRFRMENRPQ--PGA---------VLDMN-VAASLEIFNRTSM-EIRKKSLDLTGYLEH-L-YPLDFSIITPSNPAERGAQLSLRLG--G-D-------NGVVIDERKPDVIRVAPAPLYNTYADVWQFCQIF---FD
Aurantiochytrium_limacinum_Aurli1_123094      -------------MDTRDELASLRDQFLFPRASDAKD--AQTVDKDDNVYLCGNSLGLQPRKAR-YVSEELDKWAELAVEGHFTDP-PWVTV-ELC-DDMA-VVGAKSSEVAIMNSLSVNLHLMMVSFYRPNGARCKILVEGKSFPSDWIATRSQIKEK----DECLIELR--S-EE-LRTE-IEATIEEHADSLALVMLSGIQYYTGQAFEMDKI--A--E--CRVGFDLAHAVGNLELKLHEWGVDFACWCTYKYLNSGPGGIGG-FVHEKF-DG-D-LEGWWGHRKTDRFKMEPNF--IPGAFGWQLSNPCVLPIATLRASLELFREATMPRLRAKSESLTRYLELL-ESELPCKSITPGFRHERGCQLSLVFSQP-KA-VHVEVKRGVICDMREPDVMRIAPAPLYNSYVDVWEFVQILK---R
Aureococcus_anophagefferens_323447713         -A---SPCATTVAADAADELRPFRDKFLFPA-------DAA----GRPVYLCGNSLGLQPASTKQAVLADLDRWAA--VEGHE-G-PAW---E-LAEAEAARLVGAEPGEVVIMNSLTVNLHLLLGAFYRPDGAREVIVVEDM-FPSDEYAVQSVVRHHGR--DPAACIVRP--GA------DFAAAVAELGDRCCVVLVGALQYYSGEWYDAKALADAA----A-LGLDCAHAAGNVPLALHADGVDFACWCSYKYLNSGPGALAG-FVHDKHTR-L-ALRGWWG-ERSSRFRMAR--E-----PGLQLSNPPTL-MV-LKEAYALHDAATM-KLRAKSLALTGYLEVLLAQLLG--QVTPRDPARRGAQLSL-FAP-T-D------KRNVFVDLRRPNVIRVAPAPLYNGFADVRAFVDCL-EA--
Batrachochytrium_dendrobatidis_328769415      MHQLIENL---LELDS--KLPSLRSDFCIPK-ATVSSQDL---NDDQE-YLCGNSLGLQPLSTRKLINEELDVWQESGVHGH--FERPWVSIDDH-IQESCNIVGAE-NEVVIMNSLTANLHFLM-PFYRPTSQRFKILLEHHAFPSDHFALETQAAFH----KKAL--IQP-S-EF-IRTEDILE-IEKHGDEIALVLFSGLQYYTGQWFDMPTITAAA-AK-CIVGWDLAHAVGNVPMQLHDWNIDFACWCSYKYLNSGPGGIGG-FIHNKHINT--RFAGWWGSDPQTKFDMNNSYSP--GAN-YRLSNP-VLAVV-LYASLNVFAK--MTELRKKSLLLTGYLEMLLDD-QSLQ-ITPRDSCQRGCQLSLLFTV-QR--VFCRLERGVVCDERKPDVIRIAPTPLYNTFADVHKFVNIMASALE
Belliella_baltica_390942403                   MNQINE----DFQMD-KDPLKSFRSKFFFPKVE----------DKE--IYFCGNSLGLQPKTTQNYIQKELSNWAEMAVDGHFHGEDAWYR-KKSK-ALAE-IVGAHE-EVVAMNNLTSNLHFLMVSFYRPNAKRFKIITEAGAFPSDMYMLETQVKFHGLDPNKAIVELAPRDGEHTLRTEDILQSIKEQGEELALVMMAGLQYYTGQVFDMKAIAQAVKDEGAFVGFDLAHAAGNVPLALHDWGVDFATWCSYKYMNSGPGNVSGIFVHENHAE--P-MAGWWGHDEGERFKMEKGFK--PGADGWQLANSNVLALAA-HASLDIFQQAGIKTLREKSETLTSYLEFLI--N-GLEIITPKNINERGCQLSLLVHKGGKA-VFDEFKNGIVGDWRNPNVIRIAPTPLYNSYEDVFRFAKI-EQSLQ
Bigelowiella_natans_Bigna1_85246              MSLL--KSPKAFTLDS----KSFRSEFYIPK--DAKRVDPE-GEAPG-IYFCGNSLGLLSKRAESYVQEECQKWKKLGVEGHFNGKRPWATIDEEV-EKLVDIVGATD-EVAVMNSLSCNLHMLLTSFYQPSKERFKIIMEDAAFCSDHHVIQSQVELRGLDKKSTIITVKPREGSHTLLTK-ILDCIEEHSEEVALVFLGGVQYYTGQFYDLAKIAKKAMTIVLLTGVDLAHAAGNVPLSLHDWEIDFAAWCTYKYLNAGPGSIGGIFVHKRF-NKL-IMAGWWGQKPKTRFQMKHEWEGIE-A--WQVSNPAVLPVC-LQASLDIFKDAGMKAVRKKSLLLTGLLEYLIKIE-KAH-ITPRDPERRGCQLSL-TTMPV-P-VHEKLAKGVIVDVREPNVIRLAPCPLYNTFSEVFRFVEMLQRALV
Bos_taurus_194664679                          M----------V--DEEDKLRHFRECFYIPKMQDLPPIDLSLVNKDEEIYFSGNSLGLQPKMVK-YLEEELDKWAKMGAYGHSVGK-PWIIG-ETI---MA-IVGANEKEIALMNGLTVNLHLLLLSFFKPTPKRYKILLEAKAFPSDHYAVESQLQLH----EKSMRIIK--E-ED-LRLE-ILEVIENEGDSIAVILFSGLHFYTGQLFNIPAI--AG-AKGCFVGFDLAHAVGNVELHLHDWGVDFACWCSYKYLNTGAGGLAG-FVHEKH-YTIPALVGWFGHELSTRFQMDNKLQLIPGVNGFRISNPPILLVCSLHASLEIFKQATMKALRRKSILLTGYLEYM-KQYF-VNIITPSCIAERGCQLTLTFSIPIKH-IIQELKRGVVCDKREPDGIRVAPVPLYNSFHDVYKFINLLT---G
Branchiostoma_floridae_260797831              MQQ--------F--DTEDPLRGLR-DFHIPKMKDLPPTDPTLVCADDDVYMCGNSLGLQPKGVR-YLEQDLDYWARYGVFGHFEGP-PWALC-EYV---SARIVGARPEEVACMNGLTVNLHLLLVSFYRPTSTRHKILIEGKAFPSDHYAMESQIRFH----ATSLLLAE--P-EQ-LRTE-LVSLIKREGDAIAAIVFSGVQYYTGQLFDMETI--AG-SKGCVVGFDLAHAVGNAELHLHDWGVDFACWCTYKYMNSGAGGLAG-FVHEKH-AADPKLLGWWGHKMSTRFRMDNKLDLSPGVNGLRVSNPPPLLVSPLLASLDVFQKTTMADLRRKSVLLTGYLEFL-KKFYPVEIITPSDPAQRGCQLSLMFSVPIGA-VFTELRRGVACDKREPNVLRIAPAPLYNSFSDVHRFVSLLG---Q
Caenorhabditis_briggsae_268579665             MQ-------DKL--TDSDALKGIRDLFHYPKAGTLPDVDPTLV--DPNIYLCGNSLGLMPKVTE-VMKEHLDKWAKMGVFGHMTGEVPWAHS-EHC-E-GR-LVGAKKEEVSIANSLTVNIHVLLTAFYKPTETRHKILLESKAFPSDHYAIESQIRLK----EESMVCME--E-EE-LRTE-IIDYIENNGDEIAIVFFSGIQYYTGQLFDIKAI--AG-RKGCLVGWDLAHAFANVPLHLHWWDVDFAAWCSYKYGCTGAGSIAG-FVHERF-HDKDRMLGWWSHKMSSRFTMDNVLDLDEGAA-YRISNPPIHCVAAMLGSLKIFDQVSLENLRSRSCYLTGYLEYL-KTLFGILIITPENFHQRGCQLSLKFSSPI-D-VYPELKRGVAVDKRYPNVIRVAPVHLYNNYVDVRRFISVLQ---D
Caenorhabditis_elegans_17550466               M--------DKL--SDSDALKEIRDLFHYPKAGTLPDADPSLVDPESDIYLCGNSLGLMPKATG-VMKDHLDKWAKMGVFGHMSGEVPWAHC-EYL---GR-LVGAKKEEVSVCNSLTVNIHVLLTSFYKPTETRHKILLESKAFPSDHYAIESQIRLK----QDSMVCLE--E-EE-LRTE-ILDYIEKNGDEIAIVFFSGIQYYTGQLFDMRAI--AG-RKGCFVGFDLAHAFANVPLHLHWWDVDFACWCSYKYGCTGAGSIGG-FVHERF-NDQERMLGWWSHKMSSRFVMDNVLDLDEGAA-YRISNPPIHTVAAMLGSLKVFDQVSLENLRSRSCYLTGYLEYL-KTLFGISIITPEEFHQRGCQLSLKFSSPI-D-IYPELKRGCAVDKRYPNVIRVAPVHLYNNYVDIRRFISVLQ---E
Canis_familiaris_73984361                     M----------V--DEEDKLRHFKEHFHIPKMQDLPAIDLSLVNKDENIYFSGNSLGLQPKLVK-YLEEELDKWAKMGVYGHEVGK-PWITG-ETI---MN-IVGANEKEIALMNGLTVNLHLLLLSFFKPTPERYKILLEAKAFPSDHYVIESQLQLH----EKSMRIIK--E-EE-LRTE-ILEVIEKEGDSIAVILFGGLHFYTGQLFNIPAI--AG-AKGCFVGFDLAHAVGNVELHLHDWGVDFACWCSYKYLNSGAGGLAG-FVHEKH-YRIPALVGWFGHELSSRFKMDNKLQLSPGVSGFRISNPPILLVCSLQASLEIFKQATMKALRRKSILLTGYLEYL-KHYY-VNIITPSCIEERGCQLTLTFSVPMKY-VFQELKRGVVCDKREPNGIRVAPVPLYNSFHDVYKFINLLT---D
Capitella_teleta_443720978                    METLE------F--DNADPLKELRG-FSIPKVQDLPYIDESMVSKQDDVYMCGNSLGLKPKAIH-TLNRELEKWSKIGVYGHTMGE-PW-AW-EDV---KEDIVGADPEEVSIMNGLTINLHLLLISFYRPTPTRHKVLIEAHSFPSDHYAVESQIRLH----ETSMICLE--E-EE-LRTE-IVKVIEDEGDSIAVIAWTGVQYYTGQLFDMETI--KG-SKGCYVGFDLAHAAGNVPLRLHDWGVDYACWCTYKYLNSGAGCIAG-FIHEKH-DNDPKLSGWWGHKLTSRFQMDNKMDRSRGVAGYRVSNAPMLCAC-LEASVQVFAKTSMEDLRHKSVQLTGYLEHL-KTAYPIEIITPADPAQRGAQLSIKFSVPGK--VFEELKRAVVLDKREPNVLRVAPAPIYNSFTDVFRFVKLLG---T
Catelliglobosispora_koreensis_522009671       -----S---EDGRLDQADP-GL-RDLFLIP------PADGG--NYA-EAYMAGNSLGLQPKATRAELLEDLDAWAQLGVEGH-DAKRPWLPYHELLTGP--RLVGGLP-ETVIMNSLTVNLHFLMVSFYRPRPGRDRIVIEDSAFPSDSYAVRSQARFHGLD-----------PDQVVVRLEDVVSYLEAEGETVALVLLGGVNYLTGELMDIPGITELAQRKGAIAGWDLAHAAGNVPLRLHDWGVDFAAWCSYKYLNSGPGALAGAFVHERHLDTL-RFEGWWSTDPATRFKMAPVATP-PKV-AWQVSNPPIFAMGPVRTSLELFDRVGMETLR-RSVKLTGYLESLL-AF-GPVIVTPRDPERRGSQLSLR--I-GKD-L-RRLEHGVVADAREPDVLRLAPTALYSSYHDCWRAV-ALASIYG
Cecembia_lonarensis_496477197                 M-NNQE---ESFRMD-QDTLSGFRDRFYFPQI-----------NGKE-IYFCGNSLGLQPKTVATYINKELDNWAKLGVDGHFYGEDAWYR-KKSK-ALSA-IVGAHE-EVVAMNNLTSNLHFLMVSFYCPDQTRYKIITEAGAFPSDMYMLETQVKFHGLDPEKCIVELSPRAGEYTLRTEDILMAIEANKENLALVMMAGLQYYTGQVFDMKAITAAAHQVGARAGFDLAHAVGNAKLELHDWGVDFATWCSYKYLNSGPGNISGIFVHERHAE-QP-FAGWWGHDEGERFRMEKGFK--PGADGWQLANSNVLALAA-HASLDIFEEAGMDRLRAKSELLTGYLEFLI--D-GLEIITPKIPNERGCQLSLLIHKGGKS-VFDEFKHGVVGDWRNPNVIRLAPTPLYNSFIDIYQFAKI-EQSLQ
Cellulophaga_lytica_325285513                 MQ----K-NE-FKLD-NDALKGYRDQFYFPKING----------KD--IYFTGNSLGLQPKTAQKFVDDVMQDWAQLGVEGH-YAEKSWWD-HERL-APMATLLGAKT-EVCVMNTLTVNLHFLMASFYRPTAKRFKIICEEKAFPSDQYMLTSQVKFHGFNPKDTIVEVKKREGEHFWRTEDVVAKINE-GDELALVLIGGVNYYNGQVFDMKTITKAGQDVGAFVGWDLAHAAGNIELKLNEWNADFASWCSYKYINSGPGNASGIYVNEKHLD-I--LEGWWGSKKETRFLMKPEFESSHTADSWQVSNPPVLSMAPYLASLEMFAEVGMPALIKRNVIVA-YLEFVL--D-EANIITPK---ERGTQLSVLLHGQGKE-LFNYLKNGVITDWREPNVIRLAPAPFYCSFEDMYRFGQI-KEILQ
Chondrus_crispus_546309105                    -----DGRP---TLDIADPLRSIRTLFSIPA--------P--------VYLCGNSLGPQPLSVRTALQTHLDKWAS--VAGH--T-P-W---DEAAAAAVAPIVGAKPGEVAIMNSLTVNLHLMLTAFYRPHGDRKCIIIEDG-FSTDEYALQTHITARGLD-PASVVL-QP-TGERLLRD-DILSTISLSAARLALVLLPGVQYYTGQLFPLAEACRVA----V-IGFDLAHAVGNIPLSLHKWGANFAVWCSYKYLNAGPGAVGG-FIHEKH-A-D-RHAGWWG-DRTSRFLMPRD-P--R--PGFQLSNPPVFAVP-IEAA-RVFERAGM-AVRRKSVKLTAFLERLIEKKL---IVSPRDEHRRGAQLSL-VER-R-E------KRGVVCDVREPDVLRVAPAPLYNSFADVELFVDVL-HA--
Coccidioides_immitis_119188619                MD---P--PKRY-LDAQDPLREFRNQFIIPSKADLK-KSLA-VAE-ESIYLCGNSLGLQPKNARMYIDRFLQTWA-KAVLGHEDS---Y-DY--V-TS-MAQVVGALPSEVAVMSTLTGNLHLLMASFYRPTKEKYKIILEGKAFPSDHYAVESQIRHHGFDPKDA-VLIEP-DLKE-L--ERILKTIDEHASSTALILLPGIQYYSGQYLDIPTITAHAHSKGLLIGWDCAHAAGNVELKLHDWDVDFAAWCTYKYVNSGPGSM-GAFVHEKHGQV-PR-TGWWGGDKSLRFLMDNN-VPRPGA---------VLDMT-VLSSLDIFDKATM-ALRKKSLELTAYLEH-L-NSEGFSIITPSDPEARGAQLSVLLK--G-D-------NGVILDERKPDVIRVAPAPLYNTFTDVWDFVQIFFDACD
Colletotrichum_graminicola_310789744          -------MPRAY-LDQKDALRHTRDEFVIPTKQEI--TSKTLAKKEDDTYLCGNSLGLQPKRTAVRIQQYLSTWA-QGVQGHEDS--TW-NV--KAAK-IAPIVGADESEVAVMQTLTANLHFLMAAFYKPQKERHKIILESKAFPSDHFVVETQIRHHGLSPSES-VCIEP-SSTEPL--QHILSTIEHHASDTAVLLLPGIQYYTGQLLDIPTITAFAHKHSILVIWDLAHAVGNVPLKLHEWDVDAAAWCTYKYLNGGPGCIGGSFVHSRHTVT-GR-AGWWGNDKSSRFAMETK-HPVPGA---------VLDIT-LCASLEVFELAGV-ALREKSLRLTGYLEE-LEQERTFRVITPRRPEERGAQLSLMLAE-L-D-------VGVVIDERRPNVVRVAPAPLYNTFADCFDFVEQLGKAL-
Colletotrichum_graminicola_310801791          ME---KP-AFEF-LDAQDSLRHLRDEFIIPTKGSLK-KSLNGPNKQENVYFCGNSLGVPPKAVKEYIHAQLETWASIGVNGH-RG-PCW--Q-ADVAK-SAQIVGALPEEVVMMNTLTVNLHFLMASFYRPTDKKHKIILEWRPFPSDHYVIESQIQWHGLDPAKS-VQIQP---DENFYID-ILKTIDEHAEETALILLPGIQYYSGQLFDMSRITEYAQSQGIIVGWDLAHAAGNVELKLHDWNVDFAAWCTYKYQNAGPGSMAGAFVHERHGKVS-QHTGWYGGDKSVRFNMDNK---LPGA---------AIDLA-LSGALSVFSKTNM-ELRTKSLVLTAYAEH-L-DDTGFRIITPRNAHERGAQLSILLG--L-R-------AGVVCDKRKPGVIRVAPVPLYCTFQDVWKFMDAFRAI--
Corallococcus_coralloides_383452884           ---MTPY-N-V-Y-DAADPLRPLRDEFLFP--PA---------PSGAPIYLAGNSLGLQPRKARKYVQMEMEDWERLGVEGHVHGRHPWLPYHEQLTDMVARVVGAQP-EVVVMNTLSVNLHLMMVSFYRPTRERFKILIEGGAFPSDQYAVASQARFHGYDPKEAIVLM-PREGEDTLRSEDILE-IERHGKELALVMLGSVNYLTGQAFDLREITRVAHAQGCKVGFDLAHAAGNLKLSLHDDGPDFAVWCSYKYLNGGPGSLGGVFVHERHAHS-PRFEGWWGHNKATRFEMGPTFDPLPGAEGWQLSNPPIFQLAALRSSLELFDKATMAALRTKSDQLTGYLEFLLDRLAGVSITTPRDLKQRGAQLSLRFKEP-KR-LLQRLAAGIICDFREPDIIRAAPTPLYNTYLDVFRFVKA-E-HLE
Crassostrea_gigas_405951390                   M----QKRP--F--DSIDPI---REDFCYPKMKDLPKTDLQLVDPEEDVYFCGNSLGLCPKKFK-YMLVEVNKWEKTGVEGHTSGD-PWARF-EDF---MGKIVGAKKEEVAVMNGLTVNLHLQLISFYRPTPTRYKIMIESKAFPSDHYAVESQIEFH----KTAMIEIE--K-EL-LRAE-ILAKIEEEGDSIAVICLSGTQYYTGQVFDIPTI--AG-KKGCYVGWDLAHAAGNVELKLNEWGVDFACWCTYKYLNSGAGCMAG-FLHEKH-NNNPKLKGWWGHKLDTRFKMDNKWSADTGALQYRISNAPGFLGPSIKASLEIFNKTSMKEIRAKSLLLTSYLEVL-LNKYGVDILSPSDPTQRGAQLSLSFSVPILH-VFEELKRGVVCDERKPNVIRVAPAPLYCSFLDVYRGANYLDQS-Q
Cryptococcus_neoformans_134109429             ---MS---PK-DVWDQEDALNWTRGEYEIP--K-------ACGGEDGK-YFCGNSLGLLNKKARQHIMEELDVWSTSSVTGH-P--RPWKHVDEP-T-HAK-LVGAREEEVAHTSTLTSNMHNLF-SFYQPTEKRWKIVIEKGSFPSDWYAVHSHPRLHKL--DNAIIALV--E-EDTLRTEDILK-LDDNKDSIAIVWLPLVQYYTGQLFDI-SISKVH----ALLGLDMAHGIGNVECKLNEWNVDFAVWCTYKYLNAGPAAIGG-YIRSD------GLAGWWGNDARTRFHMS-N-QP-PGAK-YQHSCTPVFSSI-LLATLQLIEA-GFSNMVEKARRLTGTLEALLKASKGFKIITPA--PYRGTQLSLVI---E-E-VFDRMRKGLVGDERKPSVIRLSPVVLYNTFEEVGRAVEIVEEAL-
Cyanidioschyzon_merolae_544210763             M----------G--DENDVLAVFRQEFYCPGRSDAPKNHLGICDHDEKVYLCGHSLGLLPK--RALVSEHLELWARLGVRGHFEGPDPWYTF-LNV---E--IVGALPHEVVYMNSLTVNLHLMMIAFYRPTAKRHRILIEKHSFPSDRCVVLSQVAYH----DPATA-LE--A-SE-AGLI-LLEVLNEYSDEIALVLLPGVQYLTGQLLPMEELV-T--SKDIKIGFDLAHAVGNVVLKLHEWAPDFACWCCYKYMNGGPGAVAG-FVNEKHTTDLPRLCGWWGLERSCRFETPRALSL--GAKSFQLSNPPILALAPVVASLEIFRMAGMQAIRQKSVLLTGYLELLLKE---VLIITPQDPNSRGCQLSLKLSATAKE-LCERLNEGFICDAREPNILRVAPVPLYNSFSDVHSFVRLLT----
Cyclobacteriaceae_bacterium_499127132         M-FPEQT--ESFEMD-LDPLRRYREFFFIPE-R----------N-GRPIYLCGNSLGLQPRQVAEYIGVELDAWASLGVDGHFGGAHPWV-YKEAL----SVLVGADE-EVVAMNQLSTNLHLLLVSFYRPSSKKYRILTESGAFPSDQYILESQVKYHGFDPADAIIEMEPAAGRHTLKTEEILEAIDRHASELALVMMAGVQYYTGQRFDME----IAQ-RAAPVGFDLAHAVGNVPLALHDWGVDFAAWCSYKYLNSGPGNVSGIFVHQKHGK-FP-FAGWWGHDESERFLMKKGFKPMGGADGWLLANDNVLGLAA-HASLDLFMEAGLENLTLKSEQLTGYLAFLL--N-PIEVITPGNPRERGAQLSL--FVHKKA-LFDRINEGIVCDWRNPNVIRVAPVPFYNSFKDIYKFAHV-ENALR
Cyclobacterium_marinum_343084375              M-QIAET--E-FRMD-ADPLSTYREKFYIPE-K----------N-GQPIYFCGNSLGLQPRSVNAYLKQELEKWADKGVDGHE-GKVPWI--RKPS-RLIAPLVGANE-EVVAMNSLSVNLHLLMVSFYQPKGKKFKILTEAGAFPSDQYILESQVKFHGLLPDEAILEMAPRPNEHLLRTEDILQKIEDHKDELALIMLSGLQYYTGQLFDLEAISSAANKQGITIGFDLAHAIGNVPLRLHDWGVDFATWCSYKYLNSGPGNVSGIFVHEKHSD-LP-FAGWWGHDEKERFKMKKGFKHMPGADGWLLSNDNVLGLAA-HASLELFAEAGLDKLRKKSIQLTNYLEFAI--D-ELEIITPLKPTERGCQLSLLIHKKGKE-VFDYWDNGVVADWRNPNVIRLAPTPMYNTFQDVFEFSRI-KNSL-
Cyclobacterium_qasimii_527059814              M-NI-ERL-E-FLMD-DDPLHGFREKFHIPE-K----------N-GKPIYFCGNSLGLQPKAVNAHLINYLEKWATKGVDGHE-GDVPWV--RKPS-SLLAPLVGASE-EVVAMNSLSVNLHLLLVSFYRPKEKKYKILTEAGAFPSDQYILESQVKFHGLSPDDAILEVKPRANEHVLRTEDILEQIRRHKDELALIMLSGVQYYTGQLFDMEAISKARQHDIC-VGFDLAHAVGNVPLQLHDWGVDFATWCSYKYLNSGPGNVSGIFVHQKHSD-DP-FAGWWGYKEEDRFKMEKGFKHMPGADGWLLSNDNVLGLAA-HAALELFEKAGIENLRKKSILLTSYLEFAI--D-ELEIITPLKSTERGCQLSLLIHKKGKR-VF-DLN-GVVADWRNPNVIRLAPTPMYNSFQDVFEFSQIKNSLR-
Cystobacter_fuscus_488704730                  ---------SG-V-GEAFARRMDAEDPLRSFREEFLF-----VHGDGHLYLLGNSLGLQPRKAKEYVLAAMEDWARLGVDGHFKGSPPWM---EFHVGLMARVVGARP-EVVVMNTLTVNLHLMMVSFYRPTPERSKILMEASAFPSDQYAVAAQVRHHGYSPEQTV-PLAPRPGEHTLRHEDILD-LERHGKEIALVLLGNVNYLTGQAFDMAAITRAAHQRGCRVGFDLAHAAGNLRLSLHEDGPDFAVWCTYKYLNGGPGALGGVFIHERHLRDLP---GWWGNDRGTRFQMKPDFEPAPGAEGWVLSNPPIIQMAALRASLELFDRATMPALRAKSEKLTGYLEFLIDRLEGVHSLTPRDPGQRGAHLSLRFT---KD-MLETLAEGIHCDFRYPDIIRAAPVPLYNSFLDVHRFVSV-E-YAR
Danio_rerio_292614504                         -----------L--DQRDHLRHLRELFIIPKTSQLSKVDLSLVDSSEDIYFAGNSLGLQPKNTK-YIDEELEKWAKTGVHGHTEGS-PWAWA-ETL---MA-IVGAKTEEVALMNGLTVNLHLLMLSFYKPTPKRHKILLEDKAFPSDHYAIESQIRLR----SDSMLIIK--Q-ED-IRTE-IVSLIEREGESIALVMLSGVQYYSGQLFDMETI--AG-SKGCFVGFDCAHAVGNAELRLHDWNVDFACWCTYKYMNSGAGGLAG-YIHERH-HSIPALTGWWGHDLKTRFLMNNEMDLQPGVNGFRLSNQPILLVCPLQASLEIFNQTTMKDLRSKSVLLTAYLEFL-RHYYSVHIITPSDPQQRGCQLSLSFSSPIRA-VFEELKRGVACDMREPNVLRVAPVPLYNSFTDVHRFITVLG---S
Debaryomyces_hansenii_50427091                IEQ-AE-C---F--------------FEIPTFKSL-----GIQN-D--IYLCGNSLGLMPKITRTAINDELNAWSERGVE--FR-LT-WVDIDLP-LPLIAPIVGGK-NEVAVMGTLTSNLNAML-SFYKPSGKKTKILFEKQAFPSDYYAFLNAAKIF----EDHLIQIEIKE-KT-IETEDIIE-ITNHQDELALVCFSGIQYYTGQFFNIGEIT-CA-SFGITVGWDLAHAVGNVPLQLHDWDVDFAVWCSYKYLNSGPGGIAG-FVHEKHTNSIPRLAGWWGNNASDRFKM---LEVFPSALSYRQSNP-VIDVV-VKSSLELFKKVGIS-LRKKSVELTGFLQALLKQE--FKILSPLNK-DRGCQLSVLFQ--HKN-IMERVK-AIVCDERRPDVIRLAPLPLYNTFSETFIAVQRLIEAMD
Dictyostelium_discoideum_66809835             MDKFFYKNQEK-DLDQ----SSIKEEFYFPITKDIA-TDLS-V-KDEDIYLTGNSLGLQPKEIEKQLVNYLNDWRKYGVEGHHKGDHPFIHIDEEIASLSK-IVGALP-EVCPMNSLSTNIHVLLSNFYKPTQTRHKIIIEYGAFPSDLYVTESQIR-HSFNPETSLIKIKPRDGEYTLRTD-IINVLKEHGDSVAVVMLSGIQYFTGQFFDMKKITEV--EIGAIVGWDLAHAAGNVELSLHDWNVDFACWCTYKYLNSGPGCIAGIFVHSK--ESFSRLLGWFGNKLSNRFQKEKEFVAED-A-GFRMSNPSVA-DCALRASLSVFEKAGIKKLAEKSTIITGYLEYL--HK-KVQIITPSEANQRGSQLSL-IKIKA-Q-LKVNLNSGIVCDVRDPDVIRVAPAPLYTSFNDVKYFIQKLNENM-
Dictyostelium_fasciculatum_470250369          IEE--RRAIAE-KMDL----KSFRSEFYIPLLKDIAKCE--EQ-CDQEIYLCGNSLGLQPKETRNQLDKYLNDWQRYAVEGHMRGDHPWISIDEQV-QLLANVVGCLP-ECCPMNTLSVNLHMMMVRFYRPTATRHKIVIEQGAFPSDLYVTESQLRYHGFDPETSIIKITPRHGETTLRQE-IEDTIRREGSSIALVMLSGVQFFTGQFFNIEKITSLA-V-GAYCGWDLAHAVNNVELRLHDWNVDFACWCSYKYLNSGPGCIGGLFIHEN--RDLPRFVGWFGNKLSNRFHKEMIFQAEK-A-GYRCSNPSVADVTALRTSLEIVNRATLPALRAKARLLTGYLEYL--HE-SVNIITPTDPAQRGSQLSLEGGAAN-C-L---LSRGVVCDVREPSVLRVAPTPLYNSFSDVYNFVQILKHSL-
Dictyostelium_purpureum_330791259             MKEFLFKSNEK-ELDS----PSMKDEFNFPITDDINKADSS-L--DKPIYFTGNSLGLQPKEVNSYLA----DWRKYAVEGHVQGSHPFLHIDEEIESLAK-IVGAKK-EVCPMNSLSTNIHVLMANFYKPTSDRHKIIIEYGAFPSDLYVTESQIKNH-FEPETSLIKIKPRDGEYTLNTQ-IVDTIKQHGNSVAVVLLSGIQYFTGQFFDMKTITQA--EVGAVVGWDLAHAAGNVVMQLHDWQVDFASWCSYKYLNSGPGAIAGVFVHSK--ESD-RLRGWFGNCLANRFQKEKEFYAEE-A-GFRMSNPSVA-DCALRASLSVFEKAGVSKLSAKSKVLTGYLEYL--HK-KIDIITPKDTNQRGTQLSL-Y---I-G-IAAELKNGVICDVRDPDVIRVAPVPLYNTFTDCFMFINILNKEM-
Dyella_ginsengisoli_516032247                 ---MS----EAWQ-DAADPLAGFRDEFLIPP------------HEGREHYFCGNSLGLQPRAVRPALSAELDYWGELAVEGHFKGRAPWLNYEDY----AA-LVGALP-EVVAMNTLGVNLHLMMVSFYRPTAERPAILIEAGAFPTDRYAVESQIRYHGFDPADAL--IE-LEGDGTLTMEAIER-LAE-GHRIALLLLPGIQYRTGQAFDFKAITALAHARGCKVGFDLAHAVGNLPLALHDSGMDFAVWCHYKYVNSGPGAVGGVFVHERHAQA-PRFHGWWGNRRDNRFQMAPTFDPTPGAEGWQLSNPPILAMVPLRISLEIFRRAGMDRLRAKSLKLTGYLEWLV-T-L-LEIITPADPAQRGAQLSIR--VRGRE-LFDYLDRGIIGDWREPDVIRISPAPLYNRFADCLAFAEA-RA-SA
Echinicola_pacifica_517283863                 -------M--RYQLD-DDHLRRFRNRFYFPKV-----------NGHE-IYFCGNSLGLQPKAAKDYIEEDLKIWAEQAVDGHFDSPKPWFTVKEAL----H-ILGAKE-EVVAMNSLTANLHALMVSFYRPKGKRTKILTEAGAFPSDMYLLESQVKYHGLSPEQTIVEIKPRAGEHSLRTEDILAAIRQEGEELACVMMAGLQYYTGQLFDMEQITKAAHEQGAVVGFDLAHAVGNCPLELHSWGVDFAAWCSYKYLNSGPGNVGGIFVHERHAN-AP-FAGWWGHNESQRFNMEKGFQPMSGADGWQMSNGNVLGMSA-HASLDIFLEAGMPKLREKSLLLTGFLEYLI--D-GLEIITPADQEQRGCQLSLLIHKGGKA-VFDDFKNGIVGDWRNPNVIRIAPTPLYNSYEDVYRFAKV-EQSLS
Emiliania_huxleyi_551569804                   -----DAQPAAL--RALDAASTFRSHFAIPP-------RPSAAS-AEPVYLTGHSLGLQPRSAQGAVMCELTKWAERG--GH--G--PW---E-AVVPLLGELVGAADAEVAAMNSLTVNLHLLMAAFYRPSAGRAGILIEAG-FPSDRYAVASQVRHHGHDPAEWLTEVAP-EESGLLST-DLLAAIDTLQDSLALVLMEAIA--RGRRINS---SRAA---PI-LGLDLAHAAGNVPLSLHDWGVDFAAWCTYKYLNAGAGCL-GIFVHSRH-ADL-ALTGWWGVAPGPRFEMRRG-E--ARRAGFACSNPAGY-EL-LH-----EEELTVPAAAQAQPARCG-------------IITPADPRRRGCQLSLRGSG---G----ALSRGVVVDAREPDIVRAAPVPLYNSYEDVRVFVLLA-AL--
Fibrella_aestuarina_436836127                 MS---V-LP-RLRLDQADPLRTYREQFHMPQ-------------GQPLIYFCGNSLGLQPKATRAAIDQELAVWQQLAVEGWP-L--PW---H-RSKAALAHIVGGTEAEVCAMNNLTVNMHLLLTSFYRPTEGRTQILTISG-FPSDQYALETHVRARGLDPKQVLVEVAP-PDAVTWQL--LLDAIDQHADQLALVLLSGVHYYTGQAFDMAAIARKA----I-VGFDLAHAVGNVPLNLHEWGVDFAFWCTYKYLNSGPGGLSGVFVHEKHDAAS-RLAGWWGYDQTRRFEMTG----VR--DGWQVSTPTVLSM--AHTAVQLTAAAGM-NLRRKSEQLTAYLQFLLTDLQG--IITPADPAQRGCQLSLLVAQ-G-A------KAGIIGDWREPDCIRLAPTPLYNTFDEVWQVADTL-R---
Fibrisoma_limi_496583666                      -----V-FN-SFQLDRTDPLRHFRDRFYIPE-------------G-KSVYFCGNSLGLQPKAVREAVNAELATWQHLGVEGW--G--PW-SFK-AL----GQIVGAAPSEVCPMNALTVNLHLLLASFYQPTPAKYKILTIAG-FPSDQYALETHVAFRNLPADAIIE-VAPPDG--LIHT-DIQRAIAEHCESLALIWLSGLNYYTGQVYNMAAIAETA----I-VGFDLAHAIGNVPLRLHDWGVDFATWCSYKYLNGGPGAVSGIFVHEKH---Q-RLAGWWGYQEENRFAM-T--GFVR--DGWQLSTPNIVAL--MHAALSITAEAGM-QLRRKSEQLTGFLEHVLDAGFG--ILTPADPNQRGCQLSLLVKA-G-A------STGIIGDWREPDCIRLAPNPLYNTFEEVWQVGETL-S---
Fischerella_sp_515877336                      ------------L-------ASYRNKFYIPK-----------TTFGQ-IYFCGQSLGLQPVTVQDYIEQVLHSWRTLGFKGHFRGNSPWIFYSDSL-PKMARIVGARE-EVVIMNTLTVNLHLMMVSFYQPTPHKYKILVESQVFPSDRYAIKSQIQFHGYDPATTLLEIQPRKGETCIRTE-IESLLDKEGASIALVLLGGVNYLTGQFFEIKKIAER--FHDCIVGLDLAHAVGNVPLALHDWNIDFAVWCNYKYMNAGPGAIAGCFVHEK--ESFPRLAGWWGGDVKTRFLMGPDFQ--P-LSGWQLSNPDILSLASLAASLDIFETAGIERLRAKSKQLNSYLEFLLDRT-SIS-ITPRDPEQRGCQL---FSIKD-D-VLEQLECGVFCDWREPDVIRVAPVPLFNTYTEVFDFVAILNNILT
Flavobacteria_bacterium_496143392             -MNFSQ-----FLLD-SDPLKSYRDLFHIP-IQN----------GAEV-YFTGNSLGLQPKSARAYVERVMKDWETMAVEGH-YSKEPWWE-HEKL-APLASLVGAKT-EVSVMNTLTVNLHFLMVSFYRPSPKRFKILCEEKAFPSDQYMLQSQVKFHGYDPDTAIVTVKKRPGENAWREEDLLEAIAL-GDSLALVLMGGVNYYNGQVFPMKSITAA-KEKGAFVGWDLAHAVGNVPLQLHDWGVDFASWCSYKYLNSGPGNAAAIYINEQYLNTD--FEGWWGTEKGLRFKMEPNFTPMDNADAWQVSNAAILAMAPFLASLDIFKTVPQEDLWSKQSRLVSYMSFVIA-P-D--ILTPE---YRGSQLSVYFHEHGRA-IFDYLSQGVVTDWREPNVMRFAPVPLYNSFKDIYTLGER-KAIL-
Flavobacteriaceae_bacterium_498208272         IFKNSE-----FQLD-QDPLNHYREQFHFPKHNG----------KD--IYFTGNSLGLQPKLARTYIDEILKDWETLGVEGHEA-KKPWWD-HERFTQLSK-IVGGMP-EVTVMNTLTVNLHLLMVSFYRPTTKRFKIICEEKAFPSDQYMIASQVRFHGYKPEDAIVEIKKRPGEHNFRTEDVLKTIENIGDECALLLIGGVNYYTGQVFDMEVISAAAKKQGAFVGWDLAHAVGNVELKLHDWNVDFAAWCSYKYMNSGPGSASGCFVHKKH-HGLP-FEGWWGHHKKERFLMAP--EFVPDVNAWQISNAPVLSMAPYLASLQMFDAVGMDAIIKRN-LIVSYLEFILSDK-GFEIITPSNPEERGTQLSVFLHGYGKK-VFHYLENGVSVDWREPNVIRLAPAPLYCNYTDMFDFGKI-EAIIK
Flavobacteriaceae_bacterium_518217641         --MLEER--YK-L-DQKDELKSYRNQFHIPK--D---------K-QGDIYMTGNSLGLQPKQTKAYVNQELNDWANLGVEGHEA-KNPWLAYHEFLTES---VVGAKP-EVVVMNTLTANLHFMMVSFYKPTKTRYKILIESDAFPSDKYAVESQLRHHGFDDKEGV-LWKPRPGEELLNYDD-LEILET-GDEIALIMIGGVNYYTGQYFDLKRITQLGHKQGCNVGFDCAHGAGNVALNLHDSGADFAVWCTYKYLNSGPGSLAGCFVHERHAYR-DLFTGWWSHNKQTRFNMRGEFDQLPGAEGWQLSNPPILSMAAIKASLDLFNEVGMDKLINKSKKLTGYFEYLL-Q-LDIRIITPKRSEERGCQLSI--QVKNAD-LHNKLEVGIISDWREPDVIRCAPVPLYNSFEDVYRLVEK-KG-L-
Flavobacterium_branchiophilum_347535574       --MIFK--NLQFQWD-QDALRDYKNQFHFPK--H----------NGKNIYFTGNSLGLQPKQTQKYIDEIMNDWANLAVEGH-FAQKPWWD-QERFVPLSK-LVGAKP-EVTVMNTLTVNLHLLMVSFYNPKPSKYKILCEEKAFPSDQYMLQSQVQFHGYDPSDAIITVKRRPGEHHIRTSDVLDLLDQ-GHEIALVLMGGVNYYTGQVFDIEQITKKGQAHGAHVGWDLAHAAGNIHLDLHQWGVDFAAWCSYKYMNAGPGNVSGCFIHEKH-HQL--FAGWWGHDKKTRFKMDDTF--CPGADGWQISNLPVLSLAPYWAAIEMFDKIGMPTLIKRNQI-TAYLDFIL--N-EFEIITPTNPNERACQLSVFLHGEGRE-LFDFLANGVIVDWREPNVIRLAPVPFYCSFEDMYHFGQI--AILN
Flavobacterium_sp_518925889                   MQN-SE------K-DRDDPISYLRKEFHIPT--D---------K-EGNLYFTGNSLGLQPKITKKYIKQELDDWAKFGVEGHEA-KNPWISYHEFLTDT---IVGAKP-EVVVMNTLTTNLHLLMVSFYQPTKTKYKIVIESDAFPSDRYAVQSQLAFHGFDPDQAL-EWKPRQGEVLLQLED-LEILDA-GDEIALLLIGGVNYYTGQYLDIKKIADLGHAKDCIVGIDLAHGAGNIQPNLHDSSVDFAAWCTYKYLNSGPGSLSGLFVHEKHAYR-PRFAGWWNHNKETRFNMRQPFDVMSGAEGWQLSNPPILSMAAIRASLDMFEKVGMDVLLEKSKKLTGFFEYLV---QDIKIITPSNPNERGCQLSV--QVANKN-LHKKLENNIITDWREPDVIRCAPVPMYTSFEDVYRMVNV-ES-L-
Flexibacter_litoralis_392395752               ---MNE---KNFSLD-NDSLAHFRDKFWIPTLNSISK-NTN-SNEKEKVYFCGNSLGLQPKTTKAYIEQELEDWKNLGVEG-FHGKNPWLS-HKLL-NQTAKIVGAKP-EVVVMNNLTVNLHLLMVSFYRPNQKRFKILMEGGAFPSDQYAIESQVKFHGFSPDDAIVMM-PREGEETLRTEDILKKIEELGDELALVMFGGVNYYTGQFFDLEKITQAAHKVG-TAGFDLAHAAGNVPLKLHDWKVDFATWCSYKYLNSGAGGTSGVFINEKYA---P-FAGWWGHDEKDRFKM-K-KGFIPGAEGWQLSNAQILPMA-VHASLDIFEEAGFENLRQKSEQLTVYMEFLI--NFNIKIITPKNKLERGCQLSLVFDKEGKK-YHETLKRGVISDWREPNVIRIAPIPLYNSFMDCYRFYE-LK-IA-
Flexithrix_dorotheae_522021427                MQK--NQ-----K-DASDPLKSFKSEFYFP-IKNGNP-----------IYFCGNSLGLQPKITKDFIGTELEKWKNLAVDGHEQ-PDPWIDYHKSLVSC--KLLGAVP-EIAILNSLTVNLNLLLVSFYRPTQKRFKIIMEGGAFPSDQYAVASQVEFQAQGIKPDN-IIEPRKGENLLRTSDILN-I-KEGDELALVLMGGINYYTGQAYDMEAITIAGHEAGAYVGFDLAHAAGNIPLKLHKWGTDFAVWCSYKYLNSGPGSTSGVFIHEKHATN-PRFAGWWGHDQKERFLMDKKFKPMKGAEGWIQSNSQIFSIAPYLASLEIFNRAGIDNLFQKSRQLTGYLEFLVNEIIEIQILTPKSPQERGCQLSLVF-LENKK-VFEELNSGIVCDWREPDVIRVAPVPLYNSYSDVFQFYNV-S-I--
Fluviicola_taffensis_327403597                -----MKYFE-FAMD-SDALKSYRDRFHFPT-----------FTKN--VYFTGNSLGLQPKTVREKVNLELDDWAKWGVEGH-LGTNPWYK-HEFL-ESSAKIVGALP-EVVVTHSLTTNLHLLMVSFYQPKGTRTKILCEAKAFPSDLYALESQVRFHGLNPETDLVGMSPRAGEHTLRDEDILAILEL-GDSLALVMFGGVNYYTGQLLDMESITKAGKGVG-MVGFDLAHAAGNIPVKLHDWGVDFAAWCSYKYLNSSPGGVSGMFVHEKHA--NP-FAGWWGYDKSTRFQMEPGF--VPGAEGWQLSNA-ILGMAA-HASLEIFDEVGMDQLKAKSDILTAYLEFIL----AFEIITPREPKRRGAQLSILVHGK-KQ-IFDAIEKGVVADWREPNVIRVAPVPLYNSFEDVYFLGKLEE-IIE
Formosa_sp_494924573                          ----MNK-P---K-DQNDALSHYRSQFHIPK--D---------N-QGNLYFTGNSLGLQPKSTQKYIQQELDDWANLGVEGHEA-KNPWMPYHEFLTDS---IVGAKP-EVVTMNTLTTNLHLLMVSFYQPTKTKYKIVIESDAFPSDRYAVQTQLEFHGFDANEGL-EWKPRQGEELLNLDD-LEILEE-GDEIALLLIGGVNYYTGQYLDLKKIAELGHAKNCMVGIDLAHGAGNIKPELHDSGVDFAAWCTYKYLNSGPGSLGGLFVHEKHAHNL-RFAGWWSHNKATRFNMRQPLDVIPGAEGWQLSNPPILSMAAIKASLDMFNEVGMDALREKSEKLTGYFEFLL-ELNDVKIITPSNPKERGCQLSIQVRDADKS-LHKKLKAHIITDWREPDVIRCAPVPLYNSFEDVYRMVDK-KQ-LN
Frankia_sp_312195122                          ---MTP---ESQLLDTNDPLPTRR-EFH-L-----PP------HAGGTAYFAGNSLGLQPKALRARLGEELDDWARLGVEGHEA-RRPWLPYHE----LA-RLVGALP-EVVVMNSLTVNLHLLMVSFYRPTPDRHRIVIEDSAFPSDSYAVRSQAAFHGYDPDEAVVRLAPRPGEAALRSEDVVACLAEQGAGVALVLLGAVNYYSGELLDVAAISAAAHAAGAVAGWDLAHAAGNVELRLHDAGADWAAWCSYKYLNAGPGSLAGAFVHERHLDR-PKLAGWWSTDPASRFQMAPTVTP-DSA-SWQLSNPPILALAPVLLSLEMFDQTGLPALR-KSVRLTAYLESLL--VC--EIITPREPERRGAQLSVR--V-G-D-V-GPLERGVLADARRPDVIRLAPAPLYCTFHDCWRAA-ALAAVLD
Frankia_sp_494780408                          --SLVQ---ERRLLDAGDPLPTRRG-FHVP-----P-------HGDGEAYFAGNSLGLQPKALRARLGEELDDWASLGVEGHEG-RRPWLSYHE----LA-RLVGALP-EVVVMNSLTVNLHLLMVSFYRPIPERHAILIEDAAFPSDSYAVRSQAALHGYDPDEAVIRLTPRPGEAALRSEDVVAHLAEHGRKVALVLLGAVNYYSGELLDITAITAAGHAAGAIVGWDLAHAAGNVELRLHDAGADWAAWCSYKYLNAGPGSLAGAFVHERHLDR-PKLAGWWSTDPSTRFQMAPAVSP-DSA-AWQLSNPPILSMAAVLLSLEMFDQTGMAALR-KSLRLTAYLETLL--VC--ELVTPREPARRGAQLSVR--V-G-D-V-TER--GVFADARRPDVIRLAPAPMYTTFHDCWRAA-ALAAVLD
Frateuria_aurantia_383317264                  ----MERSPAA---DAADPLRHCRDAFLIP-PGA--------S--DSH-YFCGHSLGLQPRQTAAELQQELQDWASLGVEGHFKGRRPWLDYHRRLTRP---LVGARD-EVVAMNSLSVNLHLLMVSFYRPTAERPAILIEAGAFPSDRYAVESQIRFHGLDPAKAL-ELHPDQADGSFSDQAICE-FAE-GPKLALALLPAVQYRTGQAFPLADISRWAHAQGCLVGFDLAHAVGNLDLQLHASEVDFAVWCSYKYLNAGPGSIGGAFVHQRHAQT-PRFAGWWGQQQATRFQMGDRFEATPGAEGWQLSNPPIFAMAPLLASLELF-QAVMTALREKSIRLTGYLEWLI-T-L-VQVLTPRDPRRRGAQLSLRV-LGGRD-LFEHLDGGIIGDWREPDVIRLSPVPLYNRYADCRAAVDA-AQ-MR
Galbibacter_sp_496280101                      -----EK-NEFALLD-KDTLQSYKQEFIFPQFNN----------KN--LYFTGNSLGLQPKRTRGFLDEILNDWGNLAVEGH-YADKPWWD-HQRL-APAK-VVGAQT-EITVMNTLTVNLHLLMVSFYQPTKKRYKIICEEKAFPSDQYMFLSQLRNHGLTPQDALIVLKKRPGENHWRTSDILEKIEL-RDELALVLIGGVNYYNGQVFDIKTITKAAKQTGAMVGWDLAHAAGNIPLELHNWEVDFAAWCSYKYMNSGPGNASGVFINQKY-HNR--FEGWWGTKKETRFQMKPEFEPMENADAWQISNPAVMTMAPYLASLEMFEEVGMQALNAKSKTLTGYLEFILNKN-KLEIITPK---DRGCQLSL--FVHGKE-LFDYLNNGVIVDWREPNVIRLAPVPFYNSFEDLYEFGQI-KAI--
Galdieria_sulphuraria_545701317               M----------L--DEQDELSSFREAFHIP---EAEST--STME-QKTIYLCSNSLGLQPKHTES-LLNHLKTWKNQAVGGHFFGTEPWASIDIPI---AK-VVGGLPSEVTCMNSLTVNLHLFLLAFYRPTAKRHKILIEASAFPSDDYAVQSQILLH----EESIIRVA--E-GF-FSES-VLDEIYNNNETLCLVLLPGVHYLSGQVF-------TC-ELDIFVGFDLAHAVGNVPLHLHDWGVDFACWCSYKYLCGGPGSIGG-FLHHRH-NGIPRLVGWWANRRETRFQMKSSLDCTPGVYGFQVSNPSVFSIVPVIASLEVFDRTSMSQIREKSIQLTGYLAFL-ER---IDIITPREPTQRACQLSLRLKQHNKQ-VHESLCRGVVCDTREPDVLRVAPFPLYNTYREILEFVQILS---W
Gallus_gallus_50750794                        M----------L--DEEDELKNLRECFYIPKVKDLPPTDLTLVNGEESIYFVGNSLGLQPKKVK-YLDEELDKWARTGVHGHFNGQ-PWAQA-ECI---MA-LVGAQRHEVALMNGLTVNLHLLMLSFFKPTPRRYKILLEAKAFPSDHYAVESQLRFH----EKSMLMLR--E-EE-LRIE-ILAVIEEEGDSIAVILFSGVQYYTGQLFDIPRI--AG-KKGCFVGFDLAHAVGNVELCLHDWGVDFACWCTYKYLNSGAGGLAA-YIHEKH-QSIPALVGWWGHEFKTRFLMENKLQLSKGINGFRLSNPPILLVCSLQAGLEVFGQTTMKALRRKSVLLTGYLEYL-KHHY-VKIITPPQIEERGCQLTLTFSLPIKS-VFEELKRGVACDMREPNALRVAPIPLYNSFQDVHRFIEILG---T
Gillisia_limnaea_494047587                    ---M-ES-NE-FRMD-EDPLATYKDEFIFPEVNN----------KK--IYFTGNSLGLQPKSAKKYVDEVMDDWANLAVEGH-YAEKPWWD-HERF-EKAK-VVGAKP-EITVMNTLTVNLHLLMVSFYRPDAKRYKIICEEKAFPSDQYMIASQVKFHGFNPEDAVVEVKKRAGENHFRTEDILKKIEEIGDECALVLFGGVNYYSGQVLDMETITRAGHEIGAKVGWDLAHAVGNIELKLHEWNVDFAAWCSYKYMNSGPGNASGCFINEKY-HEL--FEGWWGHSKERRFLMEPEFQPEPDAHAWQISNAPILALAPYLASLDMFEKVGMPALIEKRNKIVAYLEFVL--Q-DFEIITPSNQNERGTQLSVFLHGEGKE-LFNYLKNGVIIDWREPNVIRLAPAPFYCSYEDMYEFGQI-KRILK
Gillisia_sp_497918210                         -MRF-EN-T--FKLD-EDKLASYKKEFIFPKV-N----------GKE-IYFTGNSLGLQPKSAKKYVDEVMEDWASMAVEGH-YAEKPWWD-HERF-AKLGKLVGGKP-EITVMNTLTVNLHLLMATFYKPSGKRFKIICEEKAFPSDQYMIASQVKFHGYTEDEAVVKIEKRKNEHFFRTEDVLAKIK-EGEECALVLIGGVNYYSGQVLDMETITKAGHSIGAKVGWDLAHAAGNIELKLHDWDVDFAAWCSYKYMNSGPGNASGCFINEKY-HGI--LEGWWGHNKERRFLMEPEFQPEPNAHAWQISNAPILAMAPYLASLEMFDEVGMPALIEKRNKIVAYLEFIL--D--FEIITPSKQEERGTQLSVFLHGEGKE-LFSYLKSGVITDWREPNVIRLAPAPFYCSFQDMYNFGQI-KKILE
Gloeophyllum_trabeum_521728065                --------------------RHL---FVLPSNNA----LRVP--QGDNTYLCGNSLGALPKRSAELVSEELSVWG-RAVEGHPHG-REWMNAD--VT-YLARLLGAH-SEVACMGTLTANLHLMMNVFYKPSSTRYKILCEGRAFPSDQYAFASQALLH----QDAIIELS--P-EFVLREEDILQ-IREQGTSIALVLFSGVQYYTGQWFPMQSIT-AA-EQ-CICGFDLAHAVGNVPLSLHDWGVDFAVWCSYKYLNSGPGGIAG-YMHDRWDDIVPKLAGWWGHDPATRFQMPPTFSPI-GAQGFQQSNPSVLATV-LLGSLQVFEEGLMG-IRAKSLELTGLLE-KLTEN--FTIITPSE-ESRGAQLSLLF---TQK-VFDELSYGVVGDERKPDVIRLAPAPLYNTADDCERAAAVMETVF-
Herpetomonas_muscarum_537372252               -RNGASSI--AF-VDEQDPLREHRDSFNIPK------------N-DEP-YMVAHTLGLQHVGVEAAMQGCLRKWQQQAVEGNYMQPNPW-EI--T----KKDLIGASASEVAVMNSHTVNLHMMMAAFYRPTSTRRKIMMESQGFPSNTHALVSQLEVH--S-DPS-DLIT---GEE-WSTESILAAIDRHGDETAVLVLGAVHFLTGQFFDVPAIVAAAHAKGIVVGLDCSHAVGNVPLQLHDWEVDFATWCTYKYLSGGPGNVGAAFVHSKHTLA--YLKGWWGHDRQTRFSLRRTFD--EGA---------VMGTC-LTPSLRLIASVGV-ALRDKSQHLTAYLEL-L-EL-G--VVTPANPAARGAQLSIRI-R---DC---EVQRGVMV-NRPPDILRITPAPLYNSYADVLLVARAVS-LF-
Homo_sapiens_4504937                          M----------V--DEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENIYFLGNSLGLQPKMVK-YLEEELDKWAKIAAYGHEVGK-PWITG-ESI---MK-IVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLH----EESMRMIK--E-EE-LRIE-ILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAI--AG-AKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAG-FIHEKH-HTIPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGYLEYL-KHNY-VNIITPSHVEERGCQLTITFSVPNKD-VFQELKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLT---D
Indibacter_alkaliphilus_496323979             M-KLQERK-EDFKMD-KDPLGSFRAEFLFPKVD----------GKE--IYFCGNSLGLQPKSTKNYIEKELGNWANLAVDGHFHGEDAWYR-KKSK-ALAA-ILGAHE-EVVAMNNLSSNLHFLMVSFYQPTKTKFKIITEAGAFPSDMYMLETQVKFHGLNPAEAIIEIGPRKGEHTIRTEDFVKAIEENKDHLALVMMAGLQYYTGQVFDMEAITAAGHNAGANVGFDLAHAAGNVPMKLHDWGVDFATWCSYKYMNSGPGNISGIFVHERHAE-PP-FAGWWGHDEGERFKME-KFI--PGADGWQLANSNVLALAA-HASLDIFMRAGMNKLREKSELLTGYLEFLI--S-GLEIITPKEPKERGCQLSLLIHKGGKE-VFDEFKNGIVGDWRHPNVIRLAPTPLYNSFLDVYRFARI-EQSLK
Kangiella_aquimarina_517452498                M-DIF-D-----R-DQQDPISRMREQFHIPK-QD---------NGDDEIYLCGNSLGLQPKRTQEYLNYELSQWQKLGVKGHFSGDFPWMPYEESA----K-LVGAKN-EVVCMNSLTANLHFMMVSFYRPTATRNKILIEDHAFPSDHYAVESQVRYHGFDPDQAM-LAKPREGEETLRTEDLLN-IEL-GEEIALIMLPGVQYYTGQVLDMKAITQAGHAKGCKVGFDLAHATGNIPMHLHDWDVDFAAWCSYKYLNSGPGSVAGCFVHEKH-HT-PRFAGWWGHDKDSRFKMENH--FIPSAEAWQLSNPPILSLAAIRASLDTIKDAGIQALRDKSLKLSRYLRDLL-QELAINILTPADEKASGCQLSLTVNLDGKT-VFDRIAAGVTCDFRHPNVIRVAPVPLYNSFEDAYRFVTI-KD-L-
Kangiella_koreensis_256821602                 M-NLF-E-----Q-DQQDPLHHMRDQFHIPK-QD---------NGDDEIYLCGNSLGLQPKRTQEYLNYELNQWQKLGVKGHFSGDFPWMPYEESA----K-LVGAKN-EVVCMNSLTANLHFMMVSFYRPSKTRNKILIEDHAFPSDHYAVESQIRFHGFDPDQAM-LAKPREGEETLRTEDLLN-IEM-GDEIALIMLPGVQYYTGQVLDMKTITEAGHAKGCMVGFDLAHATGNIPMNLHDWNVDFAAWCTYKYLNSGPGSVAGCFVHEKH-HS-PRFAGWWGHDKESRFRMENR--FVPSAEAWQVSNPPILSLAAIRASLDTVKEAGIDALREKSLKLTRYLRDLL-QELSINILTPADNSASGCQLSLTVNLDGKT-VFDRIAAGVTCDFRHPNVIRVAPVPLYNSFEDAYRFVSI-KD-L-
Komagataella_pastoris_254571213               MSYSAE-V-K-F--------------FHIPTFKSL-----------ENIYLCGNSLGLMPKATESAIFEELAVWKK-GVE--F--KT-WLDIDLP-VPLIAPIVGAK-NEVAVMGTLTMNLNSLL-SFYQPKGRKRKILFEKHAFPSDFYAFLNQAYLK----EDDLLQLEPRT-EY-LRTEDIIK-IEDQHEEIALMCFPGIQYYTGQYFKMKEIT-AA-EKEIIVGWDLAHAVGNVDVRLHDWDVDFACWCSYKYLNSGPGGIAG-FINERWTKSLPRLAGWWGNNASARFSMKEVFDPI-SALGFRQSNP-VVDVV-LHSSLKIIKFGGIK-IREKSIEMTKLME---KRSY-FTIITP-HTLERGSQISLLFAM-I---VFEQLS-GVICDERKPDVIRLAPVALYNSFQDVISAMEKLKASLD
Kribbella_catacumbae_521053707                --SAEEKA-----LDAGDP-GH-RELF-------IPPADGG--AFPEV-YFAGNSLGLRPKATRVELLADLDSWAELGVEGHLDAARPWLPYHSLLTGP--RLVGALE-ETVVMNSLTVNLHLLMVSFYRPAPDRFKIVIEDSAFPSDSYAVRSQARFHGFSPDEAVVRLRPRPGEDVLRTADVVERIS-DPD-VALVLLGGVNYLTGELMDIPAITAAGRAAGAVVGWDLAHAAGNVPLSLHEWDVDFAAWCSYKYLNSGPGALAGVFVHERH-DA-PLFEGWWSTDAASRFEMA-A-ES-PPADAWQVSNPPIFSMSPVRTSLELFDQVGIGVLR-RSLRLTAYLESLL-LI--LQVITPTDPSRRGAQLSLRIGG-LR----GELKVGVIADAREPDVLRLAPVPLYSLYHDCWRAV-ALAAVPE
Kribbella_flavida_284033374                   ----ME-GPEREFLDAADP-GH-RELFDVPPWPDYP--DVA--------YFAGNSLGLRPKATRSELLADLDAWAELGVEGHEAG-RPWLPYHELLTGP--RLVGALP-ETVVMNSLTVDLHLLMVSFYRPAPDRYRILIEDSAFPSDSYAVRSQAAWHGFDPDDAIVRVRPRDGEDCLRTED---VIARIGPDVALVLLGGVNYLTGELLDIPAITAAGHAAGAVVGWDLAHAAGNVPLRLHAWDVDFAAWCSYKYLNAGPGALAGVFVHERH--PGPRFEGWWSTEQATRFAMA-PLSR-PRSEAWQVSNPPIFAMSPVRTSLELFDRIGMDVLR-RSLRLTAYLERLL-IT--LRVITPADPARRGAQLSVRIGG-LR----GELKRGVIADAREPDVVRLAPVPLYSLYHDCRRAV-ALAAVPE
Krokinobacter_sp_332292562                    VNNLAAK-------DEKDPLKEYRNHFYIPV--D---------K-ENEIYLCGNSLGCQPKSVAQYIEQELNDWADLGVEGHFKEETPWMSYHEELAKP---IVGAKP-EVVIMNTLTTNLHLMMVSFYNPTPSRHKIIIESDAFPSDKYAVESQIRQRGYDPETSL-LWQPREGEELCRYED-LE-LVKEGDSVALLLIGNTNYYSGQCYPIKKITDLGHNNGSKVGFDLAHGVGNIMPDLHESGADFAVWCTYKYLNSGPGSLGGCFVHERH-HT-QRFTGWWGQNKDTRFNMRKGFDPIPTAEGWQLSNPPILSMAAVKASLDIFEEAGMSNIRAKSKKLTGYLEFLV-ELN-IAIITPSNPSERGCQLSI--QVKNAD---KSLKKGVISDWREPDVIRVAPAPLYNSYQDVFEMVER-KK-L-
Laccaria_bicolor_170088266                    M-QYP-NV------------SNQ---FIIPKN--I---GATL-DKESSTYLCGNSLGLLSERSKGLVLEELRIWG-HGVFSHPLD-RPWTKCD--VH-LLAELVGAN-KEVVCMGTLTNNLHLMMDSFYKPTPERYKVLCEAKAFPSDQYAFTSQAAAH----ETTIIQVS--E-EYTLREEDILE-LDKEGPTIALVIFSGIQYYTGQWFPMKSIT-KA-EQ-CVCGWDLAHAVGNVPLELHDWDVDFAVWCTYKYLNSGPGGIAG-FVHENWK-TEPKFAGWWGHELATRFEMPSKFSPI-GAQGFQQSNPCVLAVA-LLGSLQVVKEGMMP-LRGRSLQLTTALE---KSKYFFTIITPTK-SARGAQLSLLF---TRK-IFDALKEGVIGDEREPDVIRLAPTPLYNTLKDCEHAAESLERAF-
Leeuwenhoekiella_blandensis_497467124         MPEI-EKTYTL-K-DAADPLARFRDMFNIPK--D---------A-QNNIYLCGNSLGLQPKKAKEYVAQELSNWADIAVEGHFKAAIPWTTYHEV----AA-IVGAKP-EVVLMNTLSTNLHLMMVSFYRPTAKRYKILIESDAFPSDSYAVKSQIKEKGYDPQEGL-LWQPREGEHLNRFED-LE-LMAEGEEIALVMVGNSNYYTGQKYPIKEITQLGHRYGCKVGFDLAHGVGNIDADLHYNGPDFAVWCTYKYLNSGPGAIGGCFVHERHAND-PRFTGWWGHKMESRFNM--RVDFIPGAEGWQLSNPPILSMAPIRASLEIFAEAGFKNIRAKSKKITGYLEYLI-QLD-ISILTPENPEERGCQLSI--QVKNAD-MHDGFQAGIICDWREPDVIRVAPAPLYNSYEDVYEMTQR-KQ-LA
Leishmania_braziliensis_154339509             -RNTV-----GF-MDSVDPLREHRSSYHIPKMR------------GTA-YCAGNAMGLQHIHVEASVEVFLKKWREQAVGGPCMQPTPW-EI--MCVK-MAAIVGAKDTEVTIMNTLTVNLHLLLTAFYRTQGSKRKLMIAPHSFPSDGYCLLSLLETRGLN-GED-IKITA-GPATV-PTEAFLSVIEKRGDETAVLVVSAVQYLTGQWFDIPAIVKAARAKKIIVGVDCSHAVGNVPLHLHDWDVDFAYWCTCKYLNSGPGSLSGLFVHNKHTPC--CLNGLWSSDIKSCFSEHRRFE--PGA---------AACHV-LAPSLKLMASVGM-AIRQKSLLLTAYLEL-V-EL-G--VVTPANPNQRGAQLSLRILP---KCLQRQLDKGVII-MCSPDMVSIAPAPMYNSFADVLRVVRTLA-L--
Leishmania_major_157871361                    -RNAATAL--GF-MDEADPLREHRNSYHIPMMR--------------GSYFAGNALGVEASMA-TFLK----KWREQAVEGHFMQPTPW-EI--MCV---KDIVGAKDTEVAIMNTPTVNLHLLLSTFYHSQGSKKKIMIDLHSFPNDGYCLLSQFETRGLNPEDL-KITAP-DGPAA-PMEVFLSAIDKRGDETAVIIVSAVQHITGQWLDIPAIVKAAHAKKILVGVDCIHAVGNVPLHLHDWDVDFAFWSTCKYLNSGPGSIGGVFVHNKHTSG---LLSRWGNEIQSCFPKHHSLE--PGA-----------AACILAPSLKLMASVGM-AIRQKSLLLTAYLEL-V-EL-G--IVTPADPNQRGAQLSLRI-L--LQC---EMQRGVMI-RCPPDVVPLAPAPMYNSFVDVLRAVRIIA-L--
Lewinella_cohaerens_522027717                 ------TYAE--Q-DDKDPMRGFRERFHLPR-Q---------AN-GEPIYLCGNSLGLQPKSTKAAIDQELLDWQNLGVEGH-HAKNPWLPYHEFLTEK---IVGAKP-EVVMMNTLTVNLHLMMVSFYRPEGKRTKILMEADAFPSDRYAISSQLKFHGYDPAEHL-ELKARDGEVLIREEDIAH-LEE-GAEIALVLLGNTNYYTGQFFNMPEITKLAHAQGCMVGFDCAHGAGNVPLDLHDSGADFAVWCSYKYINSGPGSVSGCFVHERHAHD-PRFTGWWGHNKVTRFGMRDDFDPIPGVEAWQLSNPPILSLAAIKASLEVFAEAGMNNLRQKSLALTGYLEYLV-QLG-ISIITPRDPERRGCQLSIQVQDADKS-LYEAIAAGVIADWREPDVIRVAPVPLYNTFTEVYDFVKI-GE-ME
Lewinella_persica_522055487                   ---MVE--QLA-R-DERDELRAYRSQYHMPV-Q---------AN-GQPVYLCGNSLGLQPKATEGYLLQELEDWKNLGVEGH-HAKNPWMPYHEFLTEA---VVGAKP-EVVVMNTLTVNLHLMMVSFYRPVGRRKKIIIEADAFPSDKYAVESQIRFHGLSPEDCL-ELKARDGEVCLRQEDILG-IDA-SEDIALILLGNTNYYTGQFFDMKTISEHGHAKGCMVGFDCAHGAGNVPLNLHDSGCDFAVWCNYKYLNSGPGGMGGAFIHERHADS-PRFEGWWGHNKETRFKMRDAFDPTPGTEAWQLSNPPILAMVAVWSALKLFDEVGMTRLRKKAISLTGYLEYLV-NTLDVNIVTPADPAQRGSQLSIQVKTADKK-LFNKIEAGVIADWREPDVIRVAPVPMYNSYEDVYNFYTI-KS-IA
Loa_loa_312091865                             -Q-------DRIELDDADPLKFLRNEFAYPKMRTLPHVDLLLVNANDDIYMCGNSLGLMPKGTK-LMDEQFEKWANMGVFGHL--QEAWAQS-EAV---IAELVGAQRTEVALMNSLTVNLHILLAAFYKPTLKRHKIFIESKAFPSDHYAVESQIRLK----EESLICMQ--A-DD-IRND-IIALIEEQGDAIAIIWFSAIHYYTGQLFDIRKI--AG-DKGCLVGWNLAHAFANIPLSLHEWDVDFACWCTYKYSCSGAGGIGG-FVH-KR-ETDERMVGWWGHKKETRFIMDNQLDLESGAA-YRISNPPMMLIVPLIAFLEVISKTTMQDLRAKSMLLTGYLEYL-NHFPSCTIMTPSDPEQRGCQLSLKFNVDISL-VYEELKRGVAVDKRYPDVIRVTPVHLYNSYTDVHRF---MR---D
Magnaporthe_oryzae_39944710                   -----TK-PEFP---SECPIRHMREHFIFPKALDLP-FELSGL-PNDNVYFCGNSLGLQPKATRDHINAQLETWASIGVHGH-TS-PSWQAA-ASA-----SVVGASPDEIAIMNTLTANLHFMMASFYRPTEKRHKIISEWKPFPSDTYAIASQIQWHGFDTATS-VELHP---DENYYIEKILATIDEHAESTALLLLPGIQYWSGQLFDMPLITAHARAKGIVVGWDLAHAVGNVPLSLHDWDVDFAIWCTYKYLNAGPGAIAGAFVHERHGKVF-R-SGWYGNNKATRFNMAKD-DPTPGA---------GIDLA-LGAALSVYNLTTP-DLRKKSLWLTAYAEH-L-----FRIITPSNKNERGAQLSVLLRE-L-D-------AGVVCDRRKPDVMRVAPVPMYNSYEDVWRCVDALRKA--
Maribacter_sp_305664463                       MKKSTEN-CEKLFLD-EDVLNDYKSQFHFPQING----------KD--IYFTGNSLGLQPKITKSYVDEVITDWKNLAVEGH-RSDKPWWD-HERL-KPLASVVGAKK-EVSVMNTLSVNLHLLLVSFYRPTKKRFKILCEEKAFPSDQYILKSQVKFHGFDIEDAIVEVRKREGEHFWRTEDILSKINE-GEEIALVLIGGVNYYNGQVFDMKAITKAGKTQGAFVGWDLAHAVGNVELKLHEWDVDFASWCSYKYMNSGPGNASGIFVNKKYLHEI--FEGWWGTKKETRFLMKPEFEPIENADAWQISNPSVLSLAPYLASLQLFEEVGMNALIEKRDKIVSYLEFVL--I-G-NIITPN---ERGCQLSVFLHGHGRP-LFDFLESGVITDWREPNVIRLAPAPFYCSFEDMYRFGQI-LKGIK
Marivirga_tractuosa_313676925                 ----MENYNE-YQMD-EDPLKKYRNEFHIP-II-----------DGQQIYYTGNSLGLQPKRTRSFIEKEMKDWELFGVEG--FNKKIWYKYKDAI-----EIVGAKP-EVVPMNNLTVNLHLLLVSFYRPTAKKFKIIVEKGAFPSDQYVFESQLNFHAFHLQEAL-EIAPREGEDTLRTEDIIATIEEHQNELCLVMMGGLQYYTGQFFDLKKITKAAHKVG-YAGFDLAHAAGNIELKLHDWDVDFASWCTYKYLNSGPGNVSGVYVHERFA---P-FAGWWGHDEKERFKMEK--GFIPGADGWQLSNTNVLGHAAHYASLEIFKEVGMKALRKKSVLLTGYLEFLI--EFNFEILTPKEPENRGCQLSL-YLLKGKP-LFDELKRGVLGDWREPDVIRLAPVPLYNTFEEQYLFIE-LR-AVE
Maylandia_zebra_499025258                     M----------V--DKHDKLRHFREEFLVPKITELPPSDLSLVNKD--IYFSGNSLGLQPKNVK-YLEEELDTWAKIAIHGHTMGA-PWAWA-NNI---MA-VVGAKTEEVALMNGLTVNLHLLLLSFYKPTKTRHKILLEDKAFPSDHYAVESQIRLR----KDSMLLLS--P-EE-LKTE-ILEVIEKQGDSIAVVMFSGVQYYTGQLFDMACI--AG-RKGCYVGFDCAHAAGNVELELHDWGVDFACWCSYKYINSGAGGLAG-FIHEKH-HTIPTLMGWWGHDLKSRFQMTNVMELQPGVSGFRLSNQPILLVCPLQASLEVFNMTTMQALRKKSLLLTGYLEYL-KHYYTVHIITPSDPQQRGCQLSLSFSVPIKR-VFEELKRGVACDMREPTVLRVAPVPMYNSFSDVHRFIRALG---A
Micromonospora_lupini_494728308               -P-------E--HLDQTDP-GH-RHLFHVP------PAD----GGDES-YLAGNSLGLQPRATRDELLADLDAWGRLGVEGHEA-ERAWLPYHELLTAP--RLVGARP-EAVVMNSLTVNLHLLMVSFYRPAGARTRIVIEDSAFPSDSYAVRSQARFHGLDPDDTVVRLRPRPGEDALRTEDVTDYLAAEGDRVALVLLGGVNYLTGELLDIPAITAAGRAAGAVVGWDLAHAVGNVPLALHDWDVDFAAWCSYKYLNSGPGALAGVFVHERHL-PDPRFEGWWSTAAATRFEMT-PVSR-PSVQAWQISNPPIFAMGPVRTSLELFDAVGMPALR-RSLRLTGWLERLL---V-LRVVTPRDPARRGCQLSVRVGA-NAA----ELKRGVIADAREPDVVRFAPVPLYSTYLDCWRAA-ALAATVG
Micromonospora_sp_315504130                   ---------ENELRDAADP-GH-RHLFHIP------PADG---GRYPDAYLAGNSLGLQPRATRDELLADLDAWSRLGVEGHES-ERPWLPYHELLTAP--RLVGALP-ETVVMNSLTVNLHLLMVSFYRPAGERTRIVIEDSAFPSDSYAVRSQARFHGLDPDTTVVRLKPRPGSDTLGTEDVLDFLAREGHTVALLMLGGVNYLTGELMDIPAITAAGRAAGAVVGWDLAHAAGNVPLALHDWDVDFAAWCSYKYLNSGPGALGGVFVHERHLDSIPRFEGWWSTEAATRFEMT-PVSR-PAVEAWQISNPPIFAMGPVRTSLELFDSVGMPALR-RSLRLTAWLEQLL-VTP-LTVVTPRDPARRGCQLSVRIGV-SAN----ELKRGVVADAREPDIVRFAPVPLYSSYHDCWRVA-ALAATFE
Mixia_osmundae_358059419                      M-ALD-SDP--RRLDSLD--QDCRQHYAIPS-K---TITGSS--KDSDVYLCGNSLGLMPKNVSKVVSEELEIWS-RAVLGHHPLDRPWMYGD-TSE--LGEIVGAK-SEVIAMGTLTSNLHLLLSSFYTPTATRYKILYEEKAFGSDQYAFASQVIHH----AEALRALV--T-EYTLRIEDILK-IEQEGDTIAVSMLAGVQYYTGQCFQMEPIT-AA-AK-CLVGWDLAHAVGNVPLRLHKWNVDFAAWCSYKYLNAGPGAIAG-YVHERHADT-PRLSGWWGHDASSRFKMLSQFSAM-GAAGFQLSNPSVLDMA-LIAALDA-RQAAASILQQKSRLLTAYLA-TAQDRIG-SIITPDD-EQRGAQLSFIF---SEH-VMHSLKQGIIGDERRPDVIRLSPVPSYNTYRDVLQTVMAIDAILD
Monodelphis_domestica_126326297               M----------L--DEHDNLKNFQECFHIPKMKDLPLIDLSLVNEDENIYLLGNSLGLQPRNVK-YLEEELEKWAKMGGYGHEIGK-PWITG-ECI---MI-IVGAHKDEIGLMNGLTVNLHLLLLSFFKPTSTRFKILLEAKAFPSDHYAIESQLQLH----EKSMLMIK--E-ED-LRME-ILEVIEKEGDSIAVILFSGVQFYTGQLFDIPAI--AG-AKGCFVGFDLAHAVGNVELHLHDWGVDFACWCSYKYLNSGAGALAG-FIHEKH-YTMPALAGWFGHKLESRFNMDNKLDLIPGVNGYRLSNPPILLVCALEASLEIFSQTTMKTLRRKSILLTGYMEYL-KHYY-VKIMTPSHIEHRGCQLTLTFSIPMKS-VFQELKRGVVCDKREPSGIRVAPVPLYNSFHDVYRFIKALA---S
Monosiga_brevicollis_167525551                -----------L-LDEADPLAHLRQEFSIPQMKDIKQADLKLVEAESDIYLCGNSLGLMPKRTR-IVNEELDTWATGGVTGHFPGK-PWVSI-ETV-DKCA-VVGALPEEVAIMNTLTVNLHLLMVPFYRPTSDRFKILVEAKAFPSDHFAVLSQLRMH----ESALIEVK--E-EH-IREE-LLAILEEQGDSIATVLVGGVHYYTGQFFDLQRL--A--NKGCTFGVDLAHAVGNVPLQLHDWDIDFACWCTYKYLNSGPGGIAG-FIHKKH-GTSPYLQGWWGVQLNERFRMDHDASFMPGVRGLQLSNPGVLQTVALLGSLEIYEQTDMASLRAKSLKLTAYLEQL-QAEGH-EIITPTDPERRGCQLSILFKV---D-IFEALKRGVVCDVRRPDVMRIAPVPLYNTFTDVYRFVTTLR---N
Mortierella_verticillata_MVEG_00226.1         -MTITK-LNE-AAMDHRDPLNALRNEFVIPKKGEISPSD----NPE--IYFCGNSLGLLPKAVARYVKEEIEVWGEGAVNNHRFG-R-WVRIEET-QEQSARVVGAQ-EEVAIMNTLTSNLHTLF-AFYTPTEERHKVLIESKAFPSDHYAVESQIRWH----RESLICQEPRS-EV-LRTEDILE-IEKHGHEIAVVCFSGIQFYTGQYFEMEKIT-AA-AKGCIVGWDLAHAAGNVPVQLHDWNVDFACWCSYKYLNSGPGGIAG-FVHERHAKD-NRLAGWWGHDKVTRFDMVNVFKP--GAAGFQHSNP-VLTTS-LLGSLSVFEQTTMT-MRQKSYLLTGYL----TTEFSLEIITPADP-QRGAQLSLVF--KG-E-VFEGLK-GIIGDERKPDVIRIAPTPLYTRFEDVRMFVIELKKLVA
Mucilaginibacter_paludis_495786261            M-NTL------FRLD-QDNLAGFRNEFIIPQHHG----------RD--IYLCGNSLGLQPKATAGVIAEQLSNWGSLAVEG-E-GDSPWMH-HKKL-EPLAAIVGALN-EVVAMNTLTVNLHFLLVSFYRPTAKKYKILMEGGAFPSDQYAIESQVHFHGYQPDDAIIEVFPRAGEDTLRTEDIIRTIHDHADDLALVLFGGINYYTGQFYDLEQITQAAHQVG-YAGFDLAHAAGNVPLQLHHWQVDFACWCSYKYMNSSPGGISGAFIHEKHF---E--AGWWGYREDKRFEMKP--GFKPGAEGWQVSCSPLLLMAA-HASLNVFEKAGIEPLRKKSKLLTGYLEYLI-HQKQFKIITPKNENERGCQLSIVCD--NKA-IFDQLEGGVLGDWREPDVIRLSPIPLYNSFEDVYLAGKLLAGVTQ
Mucor_circinelloides_511001590                ISDII-KSS-EFNLDANNKLSEYRSEFAIPTR-RMVSGKKSIY-EDQPTYLCGNSLGLMPKRSRELINEELDAWSKRGVEGHP-G--PWATVDE----LA-HLVGAK-SEVTAMNTLTSNIHSML-TFYRPTEKRFKILIEQKAFPSDHYAVSSHLHSR----KVGLLTIA--E-EHTLRTEDIID-INKD-DEIAVVMLSGVQYYTGQFFEIEKITKAG-EA-CVVGWDLAHAVGNVPLQLHDWNVDFACWCSYKYLNSGAGGIAG-FIHEKYNN--PRLAGWWGNQKENRFEMLPEFQP-EGAS-YQLSNPSIFTTI-LLGSLEIFEK-GINELRQTSYKLTGYLELLLKEEFSIRILTPNDPQQRGCQLSLEF--PNME-VFDNLTRGVIVDDRKPTVIRVAPAPLYNTFRDCFEFVQLKAAMK-
Mus_musculus_27229113                         M----------V--DEEDKLSHFRNCFYIPKMRDLPSIDLSLVSEDDDIYFLGNSLGLQPKMVR-YLEEELDKWAKMGAYGHDVGK-PWIVG-ESI---MK-IVGAHEKEIALMNALTINLHLLLLSFFKPTPKRHKILLEAKAFPSDHYAIESQIQLH----EKSMRMVK--E-EE-LRME-ILEVIEEEGDSIAVILFSGLHFYTGQLFNIPAI--AG-AKGCFVGFDLAHAVGNVELRLHDWGVDFACWCSYKYLNSGAGGLAG-FVHEKH-HTVPALVGWFGHDLSTRFNMDNKLQLIPGANGFRISNPPILLVCSLHASLEVFQQATMTALRRKSILLTGYLEYM-KHYH-VNIITPSRAEERGCQLTLTFSIPKKS-VFKELKRGVVCDKREPDGIRVAPVPLYNSFHDVYKFIRLLT---D
Myroides_injenensis_497935495                 ------KFN--LFLD-NDSIGHYKQAFNFPIV------------KGKKIYFTGNSLGLQPKRAVDYVNEVMKDWAELAVEGH-YAEKPWWD-HERF-EPLSEVVGALP-EVTVMNTLTVNLHFLMISFYRPTEQRFKILCEEKAFPSDQYLIQTQVKLHGLNPEDAIVQIKKRPGEHNFRTEDILDAISE-GDELALVLIGGVNYYTGQVFDIKTISAAKEV-GATIGWDLAHAAGNIKLELHNWDVDFAAWCSYKYMNAGPGSASGAFVHKKH-HDN--LGGWWGHNKERRFLMEEDYDPILSANGWQVSNPSILSLAPYLASVEMFREVGM-AIINK---ITSYLEYVLKEE-A--VITPSSQEERGSQLSVLLHGKGRS-LFTYLQEGVIIDWREPNVVRLAPVPLYTSYEDVYNFGQIASDIL-
Myroides_odoratimimus_493308872               ------SFNLAYKLD-KDPLAKYRDEFNFPEV------------NGKQIYFTGNSLGLQPKRAVEYVNEVMNDWGALAVEGH-YAEKPWWD-HERL-EPLSRIVGAKS-EITVMNTLTVNLHILMTTFYRPTASKYKIICEEKAFPSDQYLIQSQVRLHGLDPKEAIIELKKRPGEHNFRLEDILEKIDE-GEEVALVLIGGLNYYTGQVFDIQTIT-HAHQYGAKVGWDLAHAAGNIELKLHEWNVDFAAWCSYKYMNAGPGSASGCFIHERY-HTD--LAGWWGHNKERRFLMEKKFDAVESAHGWQISNPSILSLAPYLASIEMFDEVGM-ALIQRN--ITAYLEFVM-DV-KYELITPKEERERGSQLSVFLHGKGRE-LFSYLKEGVIIDWREPNVVRLAPVPFYTSYEDIYRFGEI-KK--D
Myroides_odoratus_489080158                   ------KFN--LFLD-KDTLSNYRSEFNFPKV------------KGKQIYFTGNSLGLQPKRAVEYVNEVMTDWAKLAVEGH-YADKPWWD-HERF-EPSK-IVGAKP-EVTVMNTLTVNLHLLMATFYKPSGKRVKILCEEKAFPSDQYLIQTQVKWHGLDPQDVIVEVKRRPGEHNFRLEDILAKIEE-GDELALVLMGGLNYYTGQVLDMKTITAAHQ-QGAYVGWDLAHAAGNINLELHDWDADFAAWCSYKYMNSGPGNASGCFIHEKH-HTN--LGGWWGHNKERRFLMEPNYDPIEGAHGWQISNLPILTLAPYLASVELFAEIGMPLI-KRN-LITAYLEFII--T-GFEIITPTEQSERASQLSILLHGEGRA-MFTYLEAGVIVDWREPNVIRLAPVPLYTSFEDMYQFGQI-KEGIS
Myxococcus_fulvus_338530492                   ---MT-TPADT-F-DAEDALRGYRDAFHFPPGPDGKP-----------VYLAGNSLGLQPRNAARYIQEELEDWARLGVEGHHHGRHPWLHYHELVTEQAARLVGAKP-EVVVMNTLSVNLHLMMVSFYRPTKQRFKILVEAGAFPSDQYAVASQVRFHGHDAREAV-ELKPREGEETLRTEDILD-LERHGHEVALVMLGSVNYLTGQAFDLAAITKAAHAKGCLVGFDLAHGAGNLKLSLHDDGPDFAVWCSYKYLNAGPGALGGVFVHERHAHT-PRFEGWWGHDKQTRFQMGPTFHALPGAEGWQLSNPPIFQLAALRASLELFDQAGMAALRAKSERLTGYLEFLLKL-QGVRITTPRDVKQRGAQLSLRFGEP------QGLKRGIVCDFRKPDIIRAAPAPLYNSFTDVYRFVKA-E-YAR
Myxococcus_stipitatus_442317947               ----M-TTSED-R-DEADALRSFRDAFHFP-----PG-----DGKP--VYLAGNSLGLQPKNAARYVQEELEDWARFGVEGHHHGRHPWLHYHELVTEQAARLVGAKP-EVVVMNTLTVNLHLMMVSFYRPTKTRFKILVEGGAFPSDQYAVASQARFHGYDPREAI-ELKPRPGEETLRTEDILA-LDQHGHEVALVMLGSVNYLTGQAFDIPAITKTAHAKGCFVGFDLAHGAGNLKLALHDDGPDFAVWCSYKYLNGGPGALAGVFVHERHARS-PRFEGWWGHDKATRFQMGPTFDPLPGAEGWQLSNPPILQLAALRASFELFDQAGMEALRAKSEKLTGYLEFLLKL-PGVRIITPRDVKQRGAQLSLRFKGEAQG-MLKRLDAGIICDFRKPDIIRAAPAPLYCSFTDVYRFVRT-E-HRD
Naegleria_gruberi_290998277                   ---IPEIC------NSSD----------------------ECVEK--K-YFCGNSLGLQPKCLSKNIEKELQKWAHIGVEGH--GTNKWFEVEES-KNAMAKVVGAK-IEVTVMNSLTANLQVLL-SFYRPTAQKYKILVEQYPFPSDMHAVTSHVRCR----EKCITLVGP-E-EE-IRSEDIVE-L-KSDSSIALSLVGGVQFMTGQCFDMKTIAQTC-EL-IVCGFDLAHAAGNIDLRLHDWGVDFACWCSYKYLNSGPGGISG-FVHEKH-NTMPRFMGWWAREKATRFSLSTKFEP--GAA-FQMSNP-ILSMT-ILSSLRVFEMQIMSVLRSKSNLLTTYLELLIRQ-LSIF-LTPSNPNARGCQLSIRVLH-NLD-VDSELKRGVIIDIREPDIIRVSPTPLYNQFVEVYDFVQLLKEILN
Nectria_haematococca_302885551                MD---SK-PANS-LDSQDKLSHLRDEFVIPKALDIP-HGASSTNSD--LYFVGNSLGAQPKAVREYLNAQLETWASIGVNGH-MG-PPWQAE--AI---SADIVGASPSEIVIMNTLTANLHFLMASFYKPNEKRHKIILEWKPFPSDHYAIESQVVWHGLDPEKS-VKIHP---DDFIITTDILSTIDEHAEDTALLLLPGIQYYSGQLFDIPRITAYAQERGIVVGWDLAHAAGNVELKLHDWNVDFACWCTYKYINAGPGSIAGAYVHEKHGKVY-R-MGWYGGDKSVRFNMDNK---VPGA---------AIDLA-LSGALSVFNKTKM-EIRSKALVLTAYAEH-L-ESSD--IITPRDPAQRGTQLSVLLGL-E---------NGVICDKRKPDVIRVAPVPLYTRFEDVWKFMQVLRGA--
Neurospora_crassa_85091828                    -S---KK-PANT-LDAQDELRHFRNEFIIPKALDIP-TQANGTSTD--IYFVGNSLGAQPKAVRHYLEAQLETWASIGVNGH-LS-PPWQAA-ASA-----AIVGAADSEVVIMNTLTVNLHFMMASFYRPTDKRHKIILEWRPFPSDWYAFQSQIEWHGLDPEKS-VEMQP---DENLYLEKILATIDEHAEDAALLLLPGIQYYTGQLFDIPRITKYAQERGIVVGWDLAHCAGNVELQLHDWNVDFAVWCTYKYLNGGPGSMAGAFVHERHGKVF-R-SGWYGADKSVRFNMDKE-QPTPGA---------AIDLT-LAAALSVFNKTSM-DLRSKALVLTAYTEH-LRQPEG--IITPRDPLQRGTQLSLLLGL-D---------NGVVCDKRKPNVIRVAPVPMYCRFEDVWKFMEIFEAA--
Niastella_koreensis_375147778                 ---MIENSS--FYLD-QDELRSFREQFI-MPVI---------DGKQ--IYFLGNSLGLQPKRTNDYLQQVLNKWAN---YGVFMGEQPWLQ-HDHL-KPLSTIVGALP-EVVAMNQLTVNLHLLLVSFYNPHGKRNKIICEAKAFPSDQYMLETHVKYCGFNPDDVIVEVGPRKGEHTIRHEDILQAIQQHKDELALVLWGGMNYYTGQLFDMAAITKAAQAVG-KVGFDLAHAAGNVPLQLHNWNVDFAAWCSYKYMNSGPGGIGGAYIHERHN--SP-FAGWWGYDKATRFLMQKGFNATRSAEGWQLSTPSLLY-AA-HAALDLFMEAGFNRLQNKRQLLNKWLWFLL--N-AVEFITPRNEAERGCQVSMLMLQQ-KQ-VFDELRAGVIVDWREPNVIRLAPVPLYNSFEEVWQFT-ILR-ILQ
Ogataea_parapolymorpha_320580640              VSDEA----A-Y--------------FTFPTFQSMG-LDGPA---D--TYLCGNSLGLMPKNLPQAVNAELDAWAARAVE--FR-GV-WMDIDLP-VPLLAPVVGAK-SEVACMGTLTMNLNSLL-AFYRPTKLKYKIVFEKGAFPSDYYAFLNMVKLH----DSALIQLEPRP-EF-LRTEDILK-IEDQSDSIALVCLPGIQYYTGQYFEIEKIT-FA-AKDCVVGWDLAHAVGNVDLKLHDWDVDFAAWCSYKYLNSGPGAIGG-FVHEKHCRP-PRLAGWWGNDAGERFKMLEQFRPI-SALGFRQSNP-VLDVV-LKASLEMHKCGGIE-LRAKSIQLTNFLE---HASYRFIILTPTDP-QRGAQLSLLFK---ED-VFMYMS-GVICDERRPNVIRLAPAPSYNTFADCVRCVTLLNKSFQ
Oryctolagus_cuniculus_291391520               M----------V--DEKDELKHFRDYFYIPKMKDLPPIDLSLVNKDENIYFLGNSLGLQPKMVK-YLEEELDKWAKMGAYGHDVGK-PWITG-ECI---ME-IVGANEKEIALMNALTVNLHLLLLSFFKPTPKRHKILLEAKAFPSDHYAIESQLQLH----EKSMRIIK--E-EE-LRME-ILEVIEKEGDSIAVILFSGVHFYSGQLLDMPAI--AG-AKGCFVGFDLAHAVGNVELHLHDWGVDFACWCSYKYLNSGAGGLAG-FVHEKH-HTIPALVGWFGHELSTRFEMDNKLQLIPGVTGFRISNPPILLVCSLHASLEIFKKATMKALRRKSILLTGYLEYM-KQYY-VNIITPSRIEDRGCQLTLTFTVPKKN-VFQELKRGVVCDKREPNGIRVAPVPLYNSFHDVYKFVTLLT---D
Oryzias_latipes_432849856                     M----------V--DENDDLRHLRQHFLMPKVADLPASDLSLVDGGEEIYLCGNSLGLQPKMTR-YLEEELDKWARTGVHGHTDGS-PWAWA-NNI---MA-VVGAKTSEVALMNGLTVNLHLLMLSFYKPTQSRHKVLLEAKAFPSDHYAVESQIRLR----QHSMLMLS--E-EE-LRTA-ILEAIEKEGDSIAVVMLSGVQYYTGQLFDMASI--AG-QKGCFVGFDCAHAAGNVELKLHDWGVDFACWCSYKYLNSGAGGLAA-FVHEKH-HSIPALLGWWGHNLQTRFQMTNVMELQPGVSGFRLSNQPILLVCPLQASLEVFNLTNMQALRRKSVLLTGYLENL-QHYFSVRIITPSDPQQRGCQLSLAFSVPIRK-VFQELRRGVVCDMREPNVLRIAPTPLYNSFNDVHRFISTLK---D
Owenweeksia_hongkongensis_375012446           MEQFNEKC------DAEDELKNFRAQFLFPQ-H-----------KGENIYFTGNSLGLQAKNAREYISEELDDWATFGVEGHTESRRPWLKYHEFFTKPLASIVGAKP-EVVAMNGLTTNLHLLMVSFFRPEGKRKKIVCEGKAFPSDQYALRSQLRFHGLT-EDDL-EIQPDPVAELIT-DDVIE-LEKHADEIALVMLGGMNYYTGQFFDMERITRKGKEIGAVVGWDLAHAAGNMPIKLHDWDVDFAAWCGYKYLNSGPGGVSGIFVHEKHHQT-PRFEGWWGHDKETRFKMPETFKPIPTAEAWQLSNAPVFAMVPLLASLELFEQAGMQRLREKSKKLTAYLQFVVRE-TGLKIITPKDPERRGAQLSVIV--PGRK-VFDYLENGVISDWREPDVIRMAPVPMYNNFEDIFRFGKI-E-GLK
Pedobacter_agri_498287270                     ------KL-NTLFQD-KDELKHFRDQFLFPKYQD----------K--FIYLCGNSLGLQPKVAKEVINSQLDNWANLAVEG-FDGEEPWMY-HKEL-KLMAPIVGALP-EVCPMNTLTVNLHLLMISFYQPQGKRFKIIMEGGAFPSDQYAIESQVRFHGFDPSDAIIEVFPREGEEILRTEDIVAKIKEHGDEIALLLFGGINYYTGQWYDMENITKAGHSIG-MVGWDLAHAAGNVPVKLHDWNVDFACWCSYKYQNAGPGGISGIFVHEKHF-----LAGWWGYQENKRFKMEK--GFVPGADGWQVSCTQVMPMALYHASLQIFKEAGLNTLRNKSISLTSYLEFVVKEQY--KIITPKNSAERGAQLSI-IAARNKE-IFDGLAHGILGDWREPNVIRLSPVPLYNSFEDIYQ-TGAVTRILT
Pedobacter_sp_495513657                       --KVVNKTLNTLFLD-ADPLRDLRNEFLFPQ-QN----------GK-PIYLCGNSLGLQPKVAREVLDRQLNNWQNLAVEG-E-GETPWMY-HKAL-ELMAPIVGARP-EVCPMNTLTVNLHLLMVSFYKPKAKRFKIMMEAGAFPSDQYAIESQVRFHGYDPKDAIIEVSPRPGEYTLRTEDILEQISLQGDQIALVLFGGINYFTGQWFDMEAITRAGQA-G-VVGFDLAHAAGNVPVQLHDWDVDFACWCSYKYQNSGPGGISGIFVHERHFG-L--FAGWWGYQESQRFKMEK--GFVPGADGWQVSCTQVMPMALYHAALQIFEKAGIGPLRKKSKALTAYLFYLI-NNY--QVITPSSAEDRGAQVSIIAKANGKY-IFEQLANNVLGDWREPNVIRLSPVPSYNSFEDVFRTAELLL-IGR
Phaeosphaeria_nodorum_169610557               -S---D-CA----QDEKDKLTKLREDFYIPTKGDL-------INKKENIYFCGNSLGLQPTRTKEYINRYLDTWA-KGVFGHEGG---W-HI--AVKE-TSKIVGALPSEVVIMETLTANLHLLMSSFYRPTKDRWKIIIEGKAFPSDHYAALSQIAHHDLD-PSA-ITIEP-SSSAPL--EHILSVISKHAATTALVLLPGIQFYSGQFFDIELITRHCRALGITVGWDLAHAVGNVPLKLHDWNVDFAAWCNYKYMSGGPGVIGGAFVHERHGTVITR-SGWWGNDKSSRFTMDNK-VPIPGA---------ALDMT-VMASLDVFALTTM-ALRERSIRLTGYLEARL-YPGGYTIITPTNPAERGAQLSVMLR--G-D-------EGVVVDERKPDVLRIAPAPLYNTFRDVHDFIGIF-----
Polaribacter_sp_472323014                     -----EK-NE--R-DSEDQLATYRNQFHIPQ--DK-------VGNDW-LYFTGNSLGLQPKKAKEYINIELQDWAEKGVEGH-DGENPWVTYPESLSEM---VVGAKP-EVIIMDTLTANLHFLMVSFYRPTKKRHKILIESDAFPSDRYAVQSQLKFHGYS-EEDL-YWSPPKGKDLLEIKD-LEILEE-GDEIALVLIGGVNYYTGQRFDFKKIAELGHAKGCVVGIDLAHGAGNIQANLHESGVDFAAWCTYKYLNSGPGSLSGIFVHEKHAHN-PRFAGWWNHNKDTRFNMRLPFDVMPGAEGWQLSNPPILAMAPIKASLEMFEEVGMDALREKSIKLTGFMEFLF-E-LDVSIITPKNPAERGCQLSI--QVKNAD-LHQKLKH-IITDWREPNVIRCAPAPMYNSFEDVYKMVSI-KE-LD
Polysphondylium_pallidum_281206095            MKSIAKHCSNR-IIEDQDTLKSFKEKFHFPMVKDVCKCDEQK---NESIYMTGNSLGLQPKAIRSELEGYLNDWQRYAVEGHHKGEHPWISIDEEI-ESLAQVVGAKP-EVCPMNTLSVNLHVMMSNFYKPTQQRHKIVIEAGAFPSDLYIAESQIRHNGFNPDTSLIKLEPLANEFTISTD-IKSILSEHGESIAMVMIGGVQFFTGQLFDMKEITAF--SLGAVVGWDLAHAAGNVELQLHDWNVDFACWCSYKYLNSGPGCIGGLFVHER-THTD-RLLGWFGNKLANRFKKETIFEAEE-A-GFRCSNPSVA-DCSLRASLAITNGASIAALRAKSLLLTSYLETLLDHS---SIITPRDPTQRGAQLSL--HIGG-V-SAAKLVSGVVCDVRDPNVIRVSPAPLYTSFTDVKNFVNILIKSL-
Porphyridium_purpureum_contig_3401.26         V----------R--DADDPFAVFRNQFRIP---DDP---------EAPVYLCGNSLGLLSDSAQD-VHRHLEKWARRGVGGHFGGTDAWVDISQSQ---D--LVGARSHEVVYMNSLTVNLHLLMTAFYRPRGTRTKILIEDKAFPSDCHAVFTHLASR----DPAAHVVK--P-EY-LRKE-IIEAIVANRDELALVMLPGVQYYTGQVLPMQ----CN-LRIPF-GLDLAHAVGNVVLCLHEWGVDFGVWCSYKYLNGGPGGVAG-FMHDKH-NDVPRLGGWWGHDPETRFEMGP--EFVPGILGFQLSNPPVLALAPLLASLDVFEAAGVYALRQKSVQQTEFLILL-KY-LAFRIITPLDDEERGCQISILLTQGRKD-IHALLRNGVVCDTREPDVLRVAPVPLYNSFSDVLTFVDMLA---Y
Pseudoxanthomonas_suwonensis_319787284        MSDIAL------R-DAADPLRGFRDEFLVPPH------------GGGERYFVGNSLGLQPRGARAHVLEVLDKWAAEAVEGHFSGDTAWMEYHR-LVR-AR-LVGARP-EVVAMNTLTVNLHLMLASFYRPDARRPVVLMEAGAFPSDRHAVESQIRLHGLDPAECL-EVEA-ESNGTLSDQAIAD-IAA-GPRLALVLWPGIQYRTGQAFDLARIAALAHAQGARVGFDLAHAVGNLPLALHDAGADFAVWCHYKYVNSGPGAVAGCFVHERHGNA-PRMAGWWGHEASTRFRMAP--EFVPGAEGWQLSNPPVLAMAPLRASLEQFERAGMAALRAKSERLTGLLERLI-H-RDLQVVTPAEPQRRGCQLSLR--VAGRA-LFEHLERGFLGDWREPDVIRIAPVPLYNRYADVLE---L-EERWA
Psychroflexus_torquis_408492022               -----MKYN-K-E-DEADPLRAYRSEFLFPKAKD-----------GSTVYLCGNSLGLQPKQTSAFIQQELQDWANLGVEGHSHATHPWMTSNEDLAGS---IVGALP-EVVIMNTLTVNLHLMMVSFYKPTPKRFKIVIESDAFPSDIYAVKSQLKFHNIDPQEGL-LWKPRPGEHLCRTEDFEH-VKEHGNEIALVMIGSTNYYSGQAYDLKRITEVSKTKDITVGFDLAHGAGNIQPNLHNIGADFAVWCTYKYLNSGPGSLGGCFIHEKHIAD--RFVGWWGHNKDSRFNM--RVDFIPTADGWQLSNPPILSLAGTRSSLDLFDKAGFDNIRKKSVLLTGFLEFLI-DLM-ISILTPRSPEERGCQLSIQVKNANKS-LFHQLDKGVVADWREPDVIRIAPAPLYNSYTDVFTFVQI-KN-LY
Psychroflexus_tropicus_517869370              -----MKYN-R-E-DQKDPLHQFRDQFHFPIDAE-----------GQPIYLCGNSLGLQPKQTSKYVQQELTDWAKFGVEGHTDAKTPWLTSHEDLSAP---IVGALP-EVVIMNTLTVNLHLMMVSFYKPTQKRFKILIESDAFPSDKYAVESQLKFHNIDPEEGL-LWEPRKGEHLCRHEDFEA-LEQHKDEIALVMVGSTNYYSGQAFDLKRIAKRCQDDNITIGFDLAHGAGNIQPNLHDIGADFAVWCTYKYLNSGPGSIGGCFVHQKH----NRFVGWWGHNKDSRFNMRVGFDPTPTADGWQLSNPPILSLAGTRSSLDLFEKAGFDKLREKSIQLTGFLEFLI-ELD-ISILTPRTPEERGCQLSI--QMKNAD-LFDQLAKGVVADWREPDVIRIAPAPLYNSFTDVYEFVQR-KH-LH
Puccinia_graminis_309316393                   MRRLS--CSP-F-LDSIACVREFR----LPRKEPADNTD-SVINEDENVYLCGNSLGLQNRRTAEMVLAELDVWA-QAVQGHFVG-RNWKNTD---VPILARLVGAS-PEVACTGSLTTNLHILMTTFYRPTKERFKILCEANCFPSDLYAFTSQIEMH----KDALISLS--P-EFTLRSEDIVS-ITREGASIALILFSGVQFYTGQAFPIKQIT-AG-QQ-CIVGWDLAHAIGNVLLELHDWQVDFAAWCSYKYLNGGPGAIAG-FVHEKWTSPKPRLAGWFGHNPGNRFQMPNKFEPV-GAGQFVHSNPDVLSVI-LYSSLQLFAS-GMS-LRARSEELTGYLE-CLDPRYAFTIITPSV-AQRGSQLSLLF-FMN-K-VASQLELGIVGDEREPDVLRLSPVALYTSFEDCRKAVEALNSILL
Rhizoctonia_solani_471916975                  M-DIA-QQ-----LDAQD--RQFRDEFRLPTNRGLVPEDLA----DSPRYFVGNSLGPLSKRSQKFLDEEIEVWA-TGVEGHHPHDRNW--KD-AYARALAMLTGAK-SEVITMSTLTANLHLMISTFYKPKGDRYKILCEAKAFPSDQYAFASQTRAH----KDAVIELA--E-EVYLREEDILA-IQKDGSSIALVLFSGIQYYTGQWFPMEKVT-AA-DV-AICGWDLAHAIGNVPMKLHDWGADFAVWCTYKYLNSGPGGIAG-FIHDKWTGKLTSYAGWYGHNNETRFQMDPVFDPI-GAHGFQQSNPSALNLA-LLGSLELFEE-GID-LREKAVKITGYLE---KRSY-FTILTPAD-QQRGTQLSLAL-MP--K-VFEEMRRGVIGDERQPDVIRLAPVPLYVGYEDCRQ--AVL--VL-
Rhizophagus_irregularis_552911183             -FGILEKY-VKFKLDENDKLKYLRYEFTIPK-RD-VSDGVEALSPEDD-YFCGNSLGLMPRRTRDLVNQELDVWASSGVVGH--HKRPWISIEDN-IDKMAEIVGAK-IEVAVMNTLTSNLHLLM-SFYTPTTKRKKILIEPMAFPSDLYAVESQIRFH----DPAKELIKP-E-EN-VPLDNILK-IEKEGHTISLVLFSGVHYYTGQFFKIKKITEAA-KK-CIVGLDLSHAVGNVVLKLHKWGVDFAAWCSYKYLNSGPGGIAG-FLHERH-NDFPRFAGWWGSDRGTRFQVDQQFKP--GAG-FQVSNP-VLNMV-LIASLELFSKTSMVHLRAKSILLTGYLEYLLKQ-NGFK-ISPRDPHQRGCQLSLKFLD-NRD-VSRELSYGIVIDERD-DTIRVAPTPMYNNFSEVFKFVKALKIIMS
Rhodanobacter_fulvus_494142171                MQASA------WQ-DAADPLRQFRDEFLIPPHDS--------SGRAVDVYFCGNSLGLQPRAVREAVNAELDYWGELGVEGHFKGRLPWMDYHEF----AA-VVGAQP-EVVTMNTLGVNLHLMMVSFYRPTPARPAILIEAGAFPTDRYAVESQIRFHGFDPARDL-EIEPDEPNGTLSLAAIEQ-LAK-GARTALVMLPGVQYRNGQAFDLAAITALAHRHGCNVGFDLAHAVGNLPLQLHDSGADFAIWCSYKFLNGGPGAIGGAFVHARHANA-PRFAGWWGHDKSTRFQMGP--QFIPGADGWQLSNPPILALAPLRVSLEIFRRAGMARLREKSVQLTGYLEWLV-Q-N-LQVVTPADPERRGAQLSIRVTAGRRS-LFDHLAQGIIGDWREPDVIRISPVPLYNRFADCLAFAQA-QA-WR
Robiginitalea_biformata_260063638             ---MTE--NEAFRMD-EDPLASYREAFLFPK--H----------HGEEIYFTGNSLGLQPRKAAGKVREVLTDWEELAVEGH-NAKNPWWE-HEQLAPYLERIVGAKP-EVTVMNTLTVNLHLLMVSFYRPEGKRFKILCEEKAFPSDQYMLQSQLRFHGYDPAEALVEVRKRPGEHHWRTADILAAIEE-ADSLALVLMGGVNYYNGQVLDMEAITRAGQAAGALVGWDLAHAAGNVRLDLHDWGADFAAWCSYKYMNSGPGNASGVFIHQRHLKDI--FEGWWGTRKETRFLMQPEFDPMPTADAWQLSNPPILALAPYMASLELFDEVGMEALIAKRDLLTGYLEFIL----GDSIITPA---DRGCQLSVFLHGEGRP-LFDYLDHGVLPDWREPNVIRLAPAPFYCSFMDMYRFGQI--AGIQ
Rudaea_cellulosilytica_517804387              MQN--DRRAET---DAADPLRALRAKFLIPRHG----------GQDQ-LYFCGNSLGLQPLGARVHVEEVLDKWAHEAVEGHFTGQAQWMPYHE-LVR-AR-AVGAEP-EVVAMNSLTANLHLLMVSFYRPTRERPAILMEAGAFPSDRYALESQVRFHGFDPATDL-ELEPD-ADGTFSMAAIAN-IEH-GPRLALVLWPGVQYRSGQAFDLTEIARLAHAQGAIAGFDLAHAAGNLPLRLHDSGADFAVWCHYKYMNSGPGAVAGAFVHARHAHS-PRFAGWWGHEKETRFQMGPRF--VPGADGWQLSNPPILGLAPLRASLELFDDVGMAALREKSEKLTGWLETLI-A-L-LTIATPPQPGRRGCQLSLRVHTRGRE-LFEHLAHGIIGDWREPDVIRISPTPMYNTYSDVVGFVEA-EA--D
Rudanella_lutea_518832048                     -------M--NTQLDAQDPLRSYRDRFHIPQ-------------L---IYLCGNSLGLQPKAARLALDGELNTWQHLGVEGWE-G--SW---H-RCQEPLAQIVGAQPLEVCPMNALTVNLHLLMASFYRPQGAKTQILTIAG-FPSDQYALETHIRSRGLN-PDSVLIVKP--GEDGL-IQTICEAIATHVDSLALVLMSGLNYYTGQVYDMAAITQVA----L-VGFDLAHAIGNVPVQLHDWGVDFATWCSYKYLNGGPGAVSGVFVHERH---A-RLAGWWGYDEANRFKMTK--VPM---AGWQLSTPNIMGL--LHAAIDITAEAGM-ALRQKSEQLTGYLAYVLQP-FG--VLTPADPAGRGCQLSLLVKQ-G-A------ESGIIGDWREPDCIRLAPTPLYNSFSDVWQVGEAL-SFF-
Runella_slithyformis_338211507                -Q------SHEWLKDRRDALGHFRERFYLP--------------RDETTYLCGNSLGLQPKATREAIDRELTTWQN---HGV------W---E-SWLSYQKSIVGALPEEVCPMNHLTVNLHLMWASFYQPTAERYKVLTVAG-FPSDQYALETHLRFRG--YDPAVALIEP-KGEYSIRT-DILDTIAQHADELALICMSGLHYYTGQVYDMQAITAFA----L-VGFDLAHAAGNIPLQLHNWGVDFAVWCSYKYLNSGPGGVSGLFVHEKH---A-RLAGWWGYEEARRFEM-T--GFVQ--AGWQLSTPNIMAL--MHASLAIFEEAGI-NLRRKSEELTGLLEMVLQRIQG--LMTPTDPAQRGAQLSLL--I-N-K------AKGIIGDWREPNCIRLTPIPLYTAFEDIWKVGEAL-NY--
Saccharomyces_cerevisiae_323353801            ---------------YPESLRD---EFNIPTFKSM---GLSS---D--TYLCGNSLGLMPK?TRNSINAELDAWSDCAVE--FK-KV-WVSIDLP-LPLLAPIVGAQ-NEVAVMNSLTANLNSLL-TFYKPTEKRFKILFEKGSFPSDYYAFYNQCKIH----PENVFIIEPRE-ET-IRTQDILD-IEVNQDELALVCLSGVQYYTGQYFDIGRIT-AH-FPDILVGWDLAHAVGNVPLQLHDWGVDFACWCSYKYLNAGPGGIGG-FVHSKHTKPAPRLAGWWGNDPAKRFQM---LEVI-GALGFRQSNP-VIDTV-LRSSLELF--AKFNEVRKRSLLLTNYMT---EASLRFTILTPTST-EHGAQLSLYFSD-GKE-VFQYLD-GVIGDARRPNVIRLAPAPLYNTFSDVYIAVNALNEAMD
Saccoglossus_kowalevskii_291244130            -ATIA------F--DENDALRRFRLYFY-PKMKEIPTVDTSLVDGESDVYLCGNSLGLQPKGVA-YLNDELDKWAKTAVHGHFNGR-PWALA-EV----SK-MVGAKTEEVAAMNGLSVNLHLLLISFYRPTKDRYKILIEGKSFPSDHYAVESQIRLH----KESMVLAE--E-EQ-LRME-LLDLIEKEGESIAVIVFCGVQYYTGQLFDMKAI--AG-KKGCYVGFDLAHAIGNVEISLHEWDVDFACWCSYKYLNAGAGGMAG-FIHEKH-DNDPKLIGWWGHEYKSRFQMSNELELSPGVAGYRISNPPPLLVCPLLASMDIFMQVPMSDLRAKSYLLTGYLELL-QTYYSVDIITPSDPKQRGCQLSLMFSVPILK-VFEELKRGVVCDKREPNVIRVAPTAMYNSFTDVHRFITFLG---N
Salinispora_arenicola_519061563               --K--E--DEKANLDTADP-GH-RHLFHLP------PSDG---GRYQQAYLAGNSLGLQPLATRDELLADLDAWRRLGVEGHEAD-RPWLPYHELLTAP--RLVGARP-EVVVMNSLTVNLHLLMVSFYRPVGARTRIVIEDNAFPSDSYAVRSQARFHGLDPDTTVVRLAPRPGEDTLRTVDVLDLLAAEGDTIALVLLGGVNYLTGELLDIPAITAAGRAAGAAVGWDLAHAAGNVPLSLHDWDVDFAAWCSYKYLNSGPGGLSSVFVHERHLDTLPRFEGWWSTDAAVRFEMS-PVAR-PATEAWQVSNPPIFAMGPVRTSLELFDSVGMTALR-RSVRLTGYLEWLL-ITP-LAVVTPRDPDRRGAQLSVR--V-SGS---AELKRGVIADAREPDIVRFAPVPLYSTYHDCWRVA-ALAATVE
Salinispora_pacifica_517063272                -PRVSERMKEKANLDTADP-GH-RHLFHVP------PADG---GRYQQAYLAGNSLGLQPRATRDELFADLEAWRCLGVEGH-AAMRPWLPYHELLTGP--RLVGARS-EVVVMNSLTVNLHLLMVSFYRPTGTRTRIVIEDSAFPSDSYAVRSQARFHGLDPDTTVLRLTPRPGEDTLRTADVRDLLAAEGDTIALVLLGGVNYLTGELMEIPEITAAGRAAGAVVGWDLAHAAGNVPLALHDWDVDFAAWCSYKYLNSGPGGLSGVFVHERHLDTLPRFEGWWSTEAATRFEMS-PVAR-PATEAWQVSNPPILAMGPVRTSLELFDSVGMTALR-RSVRLTGYLEWLL-VTP-LAVVTPRDPARRGAQLSVRIGT-SA----AELKRGVVADAREPDVVRFAPVPLYSTYHDCWRVA-ALAATVE
Salpingoeca_rosetta_PTSG_00703.1              -----------F-LDDHDDLAHFRKEFHVPRMKTLTCVDQSLVDPETEVYLCGNSLGLQPKRTA-IVQEELDAWAKGGVTGHFDGK-PWVSI-EQV-GKAA-VVGAEEDEVAIMNTLTVNLHLLM--FYTPTPDRYKIIVEAKAFPSDHFAVVSQIEQR----ADALVEVR--D-EH-IRDE-VIAAINEHADTVALVLIGGVHYYTGQFFDLPAI--A--AQGAFMGVDLAHAVGNVELRLHDWDIDFACWCTYKYLNSGPGGIAG-FVHEKH-NTKPHFAGWWGVRLQERFKMEHDGHFMPGVRGLQLSNPGVLQTVALLGSLEIFDQTSMPDLRKKAKLLTGYLEAL-TNMFS-EIITPSDPERRGCQLSVLFGRK-KP-VFEQLKRGVICDMREPNVMRLAPVPLYNSFNDVYRFVQLLR---E
Saprospira_grandis_488736761                  MQ----QFDYA-Q-DVSDPLAHFRPQFHFPKQA-----------DGSPIYLCGNSLGLQPRLAQQLMQDEMEVWKELAVEGHFKAERPWMTYHEEFSRQLSPIVGALP-EITVMNTLSVNLHLMMVSFYRPTKSRYKIVIEGGAFPSDKYAVDSQLRFHGIDPQDGL-QLRPRMGEDHLRTEDILQ-LEREKDSIALVMLSGINYYTGQCFDMQSITKKGHEIGAMVGFDLAHAAGNVRLQLHDWGMDFAVWCHYKYLNSGPGCIAGAFVHERHLNS-PRFEGWWGHHKESRFKMPATFEPAPNADAWQISNAPILAMVPMRAALALFNEAGMDRLLAKSKKLTAYLEFLL---QDIRILTPKNPKDRGAQLSIQVQGADRS-LFDDLKNGVIGDWREPDVIRISPAPIYNSFEDVYRMVKI-K-CLQ
Schizochytrium_aggregatum_Schag1_94483        -----------------------------------------------?VYLCGNSLGLQPRRAR-YVLEEMDKWATQGVEGHFDGP-PWVTI-E---GLLA-IVGANEDEVVSMSSLTVNLSSLLVSFFQPQADRNKILIESKSFPSDYIAVRTQLQSR----ELCMLQAS--E-EE-LRTE-ILALVEQHADDLALVMLPGIQYYTGQLFQMGKL-IRL-K--CVVGFDLAHAVGNAELKLHDWGVDFAVWCSYKYLNSGPGGIGG-FVHERH-HTFPRHAGWWAHRKDDRFKMEEAF--IPGAFGWQQSNPPVLLFATLRASLELFHEATMPALRRKSEVLTRYLEIL-SLELPFSVITPSYKDERAAQLSLVFSRP-KE-VHQAVRAGVICDMREPDVMRIAPAPLYNSFMDVYRFVHILK----
Schizophyllum_commune_302692670               ---MS-DIP--I-LEP----A--RDSFVLP-------TNAAV-HRDQDVYFCGNSLGPMPKLSKQRVEEELDIWA-SAVVGHKHPKRPWKTYT-SIH-LFADIVGAK-GEVACMGTLTANLHLMLDSFYVPTKDRFKILCEAKAFPSDQYAFASKVRTH----KVAVREIA--E-EFTLREEDILD-IEREGHEIAVVLFSGVQYYTGQYFPIERITKAH--K-CIAGWDLAHAAGNIPLSLHAWDVDFAVWCTYKYLNAGPGSTAG-FMHEKWAE-KPRAAGWWGHNEATRFQMPPTFDPI-GAQGFQQSNVVVLASA-VLGGLETL-Q-AIR-FRERALVLTAALE-LLKHTK-T-IITPRE-ERRGAQLSLLF--VMRK-VFDALSLGVIGDERDPDVIRLTANPLYSSSEDVVRGARLLDEAF-
Shewanella_woodyi_170725766                   IENTL------FQQD-NDPLAHYSDQFHHPVID----------GKE--LYFTGNSLGLQPKTAKEHINQELEDWAKWGVEGHFHAVNPWVS-HEIL-PASAELVGANE-EVVCMNSLTTNLHLLFVSFYKPTAKRFKIISEAKMFPSDRYLLETQVRHHGLDPDDAIIEISPREGEYLIREEDIIAAVNDNADELALLFFGGVNYFTGQLFDMQRLTKAAHGVGALAGFDLAHAVGNVPMHLHDWDVDFAAWCTYKYLNSSAGNVGGIFVNDRHGN-TN-FGGWWGHNKERRFLMENSFEPMTGAEGWQISNAPVMGMAILKSSLDIFHEAGIENLRAKSLKLTAYLEFVF----DVNIITPTDPTQRGCQLSIKLVGTNKE-FFEALKAGVIADFREPDVIRLAPTPLYNSFEDVYLLGQ--TKVLA
Solitalea_canadensis_387790622                --NFETS----FQLD-LDTLHSFRNEFLIPKHNG----------KD--IYLCGNSLGLQPKSTKTQIESLLNQWENFAVEG-TKGVE-WLH-HEEM-QLAK-ICGAKP-EVTPMNNLTVNLHLMMVSFYRPTKQRYKILMEARAFPSDQYAIDSQVQFHGFNPEDAIIEMEPRAGESLLRTEDILATIDQHGE-LALVLMGGINYLTGQLFDMEVITK--HAKQ-TVGFDLAHAMGNVPLKLHDWGVDFAMWCSYKYMNSSPGGISGIFVHENEL--F---AGWWGYEKDTRFLMTRKFK--PGAEGWQVSTSQMLLLAAH-ASLALFDRAGFDNLRAKSELLTAYLEFII--NAGYEIVTPRDKKQRGCQLSIIAPVPKK--VFEKLENGVIGDWREPNVMRFAPVPLYNTFEDVYRFGE-LLT---
Sphaeroforma_arctica_SARC_07149.1             VQR--GEV-EF-LLNK----AHLRSEYHIPKNSGLYEVRKD-IPDSE-IYLCGNSLGLQPKGTQPLVNEELLKWQRRGVQGHDDSERRWVDIAEQS-GDMAKIVGADE-EVVIMNTLTVNLHLMLASFYTPTDTRCKILIENKAFPSDHYAVRSQVKSRGYDPDTDVILVDT-EGVDNAK---LIEAIKLHGDDIALVLLPGVQYYLGDAFDMKAITSV--QMGCVVGWDLAHAVGNIELQLHDWDLDFAVWCTYKYLNSGPGGIAGAFVHSR---SNPRLTGWWSHNLKTRFKMDNEMDKIS-A-AYAMSNPPMLQVVSLRASLNVFNMTSMKDLRSKSVMLTGYLDLLLS-K-PKNSLTSSDRTKRGCQLSL-CKVPV-P-IFEFLHSGVVCDLREPDVIRIAPVPMYNNFTDCYQFAQVLKSALE
Spirosoma_linguale_284036437                  -----E----AFQLDQADLLRPFRDRFHIPR-------------NDREIYLCGNSLGLQPKTARAAVEQELATWQNLGVEGWE-A--PW---H-TCKKALGDIVGATPAEVCPMNALTVNLHLLLTSFYRPTATKFKILTI-KDFPSDQYALETHVKQHGLQPSEVIIEIAP-PDDQLIHT-DIQNAIAEHADSLAVIWMSGLNYYTGQVYNMAAIAETA----CPVGFDLAHAIGNVPLRLHDWGVDFATWCSYKYLNGGPGAVSGVFVHEKH---A-RLAGWWGYREDRRFEMTP--LPA---DGWQISTPNILAL--LHVAISITAEAGI-ALRQKSEKLTGYLEYILSP-FT--ILTPDDPNQRGCQLSLLVRK-G-E------EQGIIGDWREPDCIRLAPTPLYNTFEDVWRVGEAL-G---
Spirosoma_luteum_517450591                    -----E--S--FRLDANDPLRSFRERFHSPR-------------GK-SIYLCGNSLGLQPKTAREALERELDTWQNLGVEGWE-T--PW---H-SCKADLAQIVGAEPSEVCPMNALTVNLHLLLASFYRPTEKRYKILTI-KDFPSDQYALETHVKHRGLNPADTIIEIAP-PNDRLIHV-DIQHALAEHADELALVWMSGLNYYTGQLYNMAAITETVRQH-QPVGFDLAHAIGNVPLQLHDWGVDFATWCSYKYLNGGPGAVSGVFVHEKH---N-RLAGWWGYREDERFAMTP----VS--DGWQVSTPNILAL--LHTSLRITAEAGM-ALRQKSQRLTGFLAHILAP-FT--LLTPDDPNQRGSQLSL---L-R-D------AQGIIGDWREPDCIRLAPAPLYNSFEDVWRVGEAL-Q---
Spirosoma_panaciterrae_522087298              -----N----SLFLDQTDPLRHFRERFYIPQ-------------GNPV-YLCGNSLGLQPKSARAALEQELNTWQNLGVEGWE-G--PW-GYK-AL----SAIVGADPSEVCPMNALTVNLHLLLASFYRPAGKKIKILTI-KDFPSDQYALETHIKHRGYSVADVLIEIAP-PDDNLIHT-DIQKAIIEQADSLALIWMSGLNYYTGQVYNMATLAETA----CPIGFDLAHAIGNIPLRLHDWGVDFATWCSYKYLNGGPGAVSGVFIHKKH---Q-RLAGWWGYREDRRFEMTP--LPA---DGWQVSTPNILAL--LHAALSITAEAGM-ALRQKSEHLTGYLEYLLTRFDG--IITPDDPNQRGCQLSLLVRK-G-K------EQGIIGDWREPDCIRLAPTPLYNTFEDVWRVGSVIED---
Spirosoma_spitsbergense_522093455             -----E--S--FRLDADDPLRPFRDRFHIPE-------------GK-PVYLCGNSLGLQPKTAREALEQELDTWQNLGVEGWETG--PW---H-SCKADLAQIVGAEPSEVCPMNALTVNLHLLLASFYHPTEKRTKILTI-KDFPSDQYALETHVRHRGLNPADTIIEIGP-SIDGLIHV-DIQHALAEHADELALVWMSGLNYYTGQLYNMAAITDTV----CPIGFDLAHAIGNVPLRLHDWGVDFATWCSYKYLNGGPGAVSGVFVHEKH---L-RLAGWWGYREDERFAMTP--VPA---DGWQVSTPNILAM--LHISLRITAEADM-ALRQKSQQLTGFLVYILAP-FT--LLTPDDPNQRGCQLSLLVRK-G-A------EQGIIGDWREPDCIRLAPTPLYNTFEDVWRVGEAL-Q---
Spizellomyces_punctatus_SPPG_08715.3          MEVLSEEV---AIMDGRDPLKHFRAKFAIPK-KDVLGHEVNTTDCEES-YFCGNSLGLQPLGTRKLVEEELDVWARSGVVGH--HDRPWVSIDDH-IEETGRIVGAK-EEVAIMNSLTVNLHFLM-SFYRPTNDRYKILIEEHAFPSDYYAVESQVRFH----ADAIIQLGP-T-EH-IQTEDILE-IARNGDQIALVLFSGVQYYTGQFFELEKIAVAA-EK-CVVGYDLAHAVGNVPLRLHDWGVDFACWCTYKYLNAGPGGIGG-FVHEKH-VS-PRLTGWWGTDPTKKFLMDNVFRP--GAN-YRVSNP-VLATV-LLGSLEVFSR--MEDLRAKSVLLTGYLEALLEG--IFT-LTPGDPAQRGCQLSLLFR--GK--VLEELNKGVVVDERKPDVIRVAPTPLYNTFTEVHRFVEILRIALE
Stenotrophomonas_maltophilia_194366371        ----MDRT----I-DAADPLRPLRSEFLIPRHG-----------GGEQTYFVGNSLGLQPRGAQAAVQEVMKQWGELAVEGHFTGPTQWLSYHRLVSA-LARVVGALP-EVVAMNTLSVNLHLMMVSFYRPTAERPVILMEAGAFPTDRHAVEAQIRFHGFDPAECL-EVQPD-TNGTISLTAIER-IAE-GPRLALVLWPGVQYRTGQAFDLDAITRAARLQGSRIGFDLAHSVGNLPLRLHDVAPDFAVWCHYKYLNSGPGAVAGAFVHERHRDS-PRFAGWWGHEESTRFQMAPQ--FTPGAEGWQLSNPPILGLAPLRASLDLFERAGMEALRSKSQGLTGMLEALV-A-LNLDIITPAEPQRRGCQLSLRV-IGGRE-LFEHLGIGVLGDWREPDVIRISPTPLYNRYLDVHHFVEE-EA--G
Stenotrophomonas_maltophilia_515924642        MSEIL-RT----V-DAADPLRAIRSEFVFPQHN----------HRDQT-YFVGNSLGLQPRGARAAVQEVMDKWASLAVEGHFTGDTQWLRYHR-LVS-AR-VVGALP-EVVAMNTLSVNLHLMMVSFYRPTAERPVILIEAGAFPTDRHAVESQIRFHGFDPATDL-EVQPD-PNGTVSLQAIER-IVA-GPRLALVLWPGVQYRSGQVFDLDAITRMARLQGARVGFDLAHSVGNVPLQLHDIAPDFAVWCHYKYLNAGPGAVAGCFVHERHRDT-PRFAGWWGHEEATRFKMAPQ--FVPGAEGWQLSNPPVLGLAPLRASLDVLDKAGIDAMRTKSLRLTGMLDALV-A-LGLQVLTPAEPERRGCQLSLRVTERGRS-LFEYLTVGVLGDWREPDVIRISPTPLYNRYLDLHHFVEE-EA--G
Stigmatella_aurantiaca_310819994              --MTESRFEEG-R-DAEDPLRSFREEFLFP--QS---------PQGEPVYLAGNSLGLQPRRAQQYVQEEMEDWARLGVEGHFHARRPWLPYHENLTGQTARLVGALP-EVVVMNTLSVNLHLMMVSFYRPTRERFKILIEGGAFPSDQYAVASQARFHGFDPKDAV-KLEPRAGEDTLRTEDILE-LERHGSEIALVLLGNVNYLTGQAFDMKALTQAAHARGCRVGFDLAHGAGNLRLSLHDDGPDFAVWCSYKYLNGGPGALGGVFIHERHARA-PRFEGWWGNDKAIRFQMGPDFVPLPGAEGWQLSNPPIFQLAALRASMELFDRATMPSLRGKGDRLTGYLEFLLDRLSGVRITTPRDVKARGSQLSLRFS---KD-LLTRLEAGVCCDFRSPDIIRAAPAPLYNSFQDVYRFVKV-E-HRD
Streptomyces_scabiei_290956051                --RTAEEAQE--L----PG--L-RELFHIP------PADGG--RYTET-YLAGNSLGLQPKATLAELTEDLSDWSRFGVEGH-DAVRPWF-GYHR---LA-RLVGALP-ETVVMNSLTVNLHLLMVSFYRPQGERTQIVIEDSAFPSDSYAVRSHVRFRGLDPDQAVTRLRPRPGEDCLRTEDVVDFLDRHGHTVALMLLGGVNYLTGELMDVPAITAAGHAAGATVGWDLAHAAGNVPLHLHNWDVDFAAWCSYKYLNSGPGALSGVFIHQRHV-TLQRLEGWWSTDAATRFRMEPVSQP-PATDAWAISNPPILAMGPVRTSLELFDAVGMAALR-RSEKLTGYLEGLLTHTR-T-VITPRDTQRRGAQLSLRVGR-S-A-AARKLEHGVVADAREPDIIRLAPVPLYSTFHDCWRAA-ALAHCVP
Strigomonas_oncopelti_537372148               -QNPAQGVL-AF--DEDDPLREHRVAFHFPR-QA---------N-D-S-YLVGNSLGLQHTGVRSAMDEFLVKWQDQAVEGHFMQPNPW-EM--MLMG----IVGASKREVILMNALTVNLHL-MLSFYHPDGKRKKILMESHGFPSDTHCMASHLEVCGMN-EED-LFVA---GHEDWTTQMFLDAIEKHGDEVAVVVLTAVHFLTGQLFDIPTIVKAAHAKGMLVGVDAAHAVGNVPLKLHDWDVDFACWCTYKYLNSGPGNIGGAFVHNKHTDE--YFKGWWGHDRKNRFSMHRNFE--DGA---------SGSIT-MAPSLKLMASV?M-KLREKSLLLTAYMEL-L--E-G--VITPADPEQRGAQLSLRI-L---ECVMQQLDAGVMI-NRPPDVVRVSPVPLYNSYTDVLQAVRAMA-LF-
Strongylocentrotus_purpuratus_390346745       M----EKTP--F--KKMDELAPLRKEFILPKMNELPDVDLSLVDKDDEIYFCGNSLGLQPKGLK-YLDAELEKWGKVGVHGHFTGQ-PWAFC-EVL---MSNIIGCKEDELAIMNGLTVNLHLLLMSFYQPTKKRHKILIESKAFPSDHYAVESHIRLN----ATSLICVE--K-EY-LRTE-VLSMIEKEGDSIAVILLGALQYYTGQLF?MPVI--AG-TRGCYVGFDLAHAVGNVELHLHDWEVDFAVFCTYKYLNSGAGSHGG-FLHSKL-QSMPKLVGWWGHKFKSRFQMNNELELSPGIAGYRISNPSIFATCPLRASLDVFRMTSMAELRAKSMVLTGYLDYL-GHHFGITILTPSNPEDRGAQLSLYFSIPIKR-IHSEMKRGIVCDERKPNVIRIAPAPLYCNYMDVWRFMDALQTIMD
Talaromyces_marneffei_212538249               MT---E-FPE-Y-LDRTDPLSAFREKFIIPSKANLK-TKLAKLSQD--IYFCGNSLGLQPRATSKYLEAQLDTWSSIGVLGH-LE-PSWQLA--A-AG-MARIVGANPEEVAAMGTLTANLHMLLASFYKPTESRHKVLLDWKAFPSDHYAIESQIEWHGLNPKDS-VLIGP-EGEYVISTEKILSVIDEHASETALLLLPGIQYYSGQYFDIPTITKHAQSRGIVVGWDLAHAYANVDVKLHDWNVDFAAWCTYKYGNAGPGAIGGIFVHERHGVV--VHTGWYGGDRSVRFKMDNK-KPIPGA---------AIDLAC--SSLSVFNKTSI-QIRAKSLRLTHYLEY-LL--AGFRIITPSDPNARGAQLSLLL-N-G-D-------AGIICDKRQPDVVRVAPAPLYNTFTEVWIFVNLKTAI--
Thecamonas_trahens_AMSG_00747.2               M----------V-LDKADGLSRFADAFAFPTLH------LEGENEDRQVYLCGNSLGLMPHKAR-YVNEELEAWAKSGVRGH-EGK-AWLWI-ERV-DAAR-LVGAKPIEVEVMNSLTMNLHVMM--FYRPTATRYKIMYEAKAFPSDSYAFASQVRMA----ADALIAVA--D-EY-LRTE-IEAAIAEAGDSLALVCFSGIQYYTGQLFDMPAI--A--AVGAKVGFDLAHAVGNVELRLHDWGVDFAAWCHYKYCNSGPGAIAG-FIHEKY-HDAHRMAGWWGHNKAERFLMEP--EFVPGAAGFQVSNPPVLQTVAVEASLEIFDEATLPALRAKALRLTMFLELA-ESAL-----GSDHV------LSLQFTKP-EA-VHAALAAGVYCDVRKPDVMRIAPVPLYNSFSDVLRFVELLA---K
Trametes_versicolor_392566839                 ---MA-KL-----APEQD--SKYRDEFVVPTF--MKPAEIA----DEPTYLCGNSLGLLPKRSKKLVEEELDVWG-RAVEGHPLG-RDWMFAD--VH-HLAQIVGAN-SEVACMGTLTANLHLMLNAFYKPTAERYKILCEAKAFPSDQYAMATQLTSR----ADAIIAMS--K-EHILRTEDILS-IEKEGSSIALVLFAGVQFYTGQWFQMKEIT-AA-AQ-CVCGWDLAHGVGNVPLSLHDWGVDFAVWCTYKYLNSGPGGIGG-FVHERWADAVEA--GWWGHDPATRFDMPPQFKAI-GAQGFQQSNPSVLATV-LLGALQVLAD-GIP-VRARSLRLTGYLE---QQSY-MTIITPAD-AQRGAQLSLVFGMPR---VLKGLARGVIGDSRKPDVIRLAPVPLYNTFEDVERAVKVLDEVLE
Trichinella_spiralis_339245045                MK---------F--DSVDELSHFRKMFKYPKMSDLPKVDLNLVDAESDIYLCGNSLGLQPKDVQ-YISEELDKWAKMGVHGHTNGKM-WAKC-EFV---NAALVGAKKCEVAVMNSLTINLHLLMAAFYRPTSSRKKILLENKPFPSDFYAVHSQVRFH----EECVVVLQ--Q-EH-LRTE-ILDYISQNGQSIALVLFSGVQYYTGQYFDIPSI--CG-AQGCIVGWDLAHAAGNVPLNLHEWKVDFAAWCSYKYLNSGCGGLSI-FIHENN-DSYPALWGWWGHEAESRMEMTNEMKF-PHDCAYRISHPPALLVCPMIASLKIYGKTSMQTLRQKSKLLTAYLEYL-NYYFGCEVITPQDPEQRGCQLSLKFSA-NSD-VYDQLKRGVVCDMRFPDVLRITPVHIYNSFNDVRRFTELID---S
Trichoplax_adhaerens_Triad1_28018             --EAA---GE-FQLDSQDKFKEFRELFYIPRKKTLPLIDLS-VDGESEIYLLGNSLGLQPKQTRQRLIEHLDKWAEMGIEGQ-HGNDRWVDFQDTMTK-C-PIVGAKP-EICVMNAVTVNIHLLMISFYQPTAERCKILIEDGAFPSDHYAVQSQIRMRGYDPDDAMIIVKARDGETTIRTEDVIAKINEFGDSIAMILLPGVQFYTCQLFDIKEITKAAHDKGCNIGWDLCHAAGAVELKLHEWDVDFAVWCSYKYLNSGPGSVSACFVHEKHAHR-DRLEGWFGHRLETRFDMSNVMES-PGA-GFQISNTPVAEVVKLVSSLDIYSRVSLPLFERKGVI---YMEALY-YFN-ADIISPTDPFGRGNHLAFKFS--G-D-V-DGLKRGIVVDVRN-EVIRASFAPLYNSFQDVYTFITLFTQGKK
Trichosporon_asahii_406700278                 ---MA----D-L-MDKEDPLNWTRSEFEIPDASGLPTVTSSSVARDGE-YFCGNSLGLLSKRGRELVMQELDTWSTSAVTGH-KYDRPWKHLDAP-T-IMAELVGAKESEVSHSGTLTGNLHNLF-TFYRPTQKRWKIVIERGSFPTDWYAAHSHPNLHDL--DNAIIALE--K-EDTFREEDILK-IEENGDEIALVWLPIVQYYTGQYFNVELCKKTH----ATFGLDMAHGVGNVKIELDKWGVDFAVWCTYKYLNAGPGAIGG-FVRDG-----DGMAGWWGNDPSVRFEMK-E-QA-PGAK-YQHSCTSALGTI-LLGTLEIIKK-GFDNMRKKADKLTGTLQELLEASDV--ILTP---EARGTQLSIEI---K-G-VFDRMKQGLVGDERFPYVIRLSPCVLYNTFSEVGRAVEILNKAL-
Trypanosoma_brucei_71744026                   -------------MDRNDPLQVHRDAFNIPKRRD---------G-DH--YLCGQTLGLQHKDVESSVAGALKRWRELGVLQHP---NPW-EV----LG-RKEIVGAQESEVITMNSYTVNLHLLLIAFYKPKGNRRLVMMGNYALPNNVYAVMSQLEARGLNPEDL-TVCAP-DGKDS-PMTEYLSIIDKRGSEIAVILLSALHFITGQLVDVQAITKAAHAKGIIVGVDCAHAVGNVPLKLHEWEVDFASWCTYRYLNSGPGNLAGAFVHTKHTQVL-TLRGCRGHE--PRDLIDPSYKFEEGA---------VLGMM-LLPSVRLIAKVGM-SLREKSLLLTSYLEL-L-E-VG--LLTSVDPSQRGAQLTIRI-L-N--G----MRY--LRDTCSTDLVFLAPVPLYNTFKDV-----LLAAIA-
Trypanosoma_cruzi_71409561                    -RNL-ESI--GF-MDRTDPLHEHREAFHFPKRRD---------G-DY--YVSGNTLGLQHKDVESNVGGVLKKWRDLGVMGNYQHPNPW--E----ES-RKEIVGAQESEVITMNSFGVNLHLLLMAFYRPKGKRRRIVTGNHASPSSTYAIISQLDSRGMNPAED-IYVSA-N-WES-PIEQFLSVIEKRGDEIAVILLSAVHFLTGQFYDLQAITKAAHEKGIFVGVDCSHAVGNVPLKLHDWEVDFACWCNYRYLNSGPSNLGGAFVHSKHTSVL-PLRGSWGHDRRNRASLHHNFE--EGA---------AVGMM-MLPSIRLMAEVGM-PLREKSMLLTSYMEL-L-ELQG--VITPVDPNQRGAQLSLRI-L-N-VC----MRQ--LCDHCPPNVIRLAPVPLYNSFMDV-----LLTAIA-
Verrucosispora_maris_330469682                ---------EAELLDAAEP-GH-RHLFHVP------PADGG--RYPET-YLAGNSLGLQPKATRTELLADLEAWSRLGVEGHEA-ERPWLPYHELLTAP--RLVGALP-ETVVMNSLTVNLHLLMVSFYRPAGERTRIVIEDSAFPSDSYAVRSQARFHGLDPDTTVVRLTPRPGEENLRTEDVTAFLAAEGHTVALVLLGGVNYLTGELMDIPTITAAGRAAGAVVGWDLAHAAGNVPLSLHDWDVDFAAWCSYKYLNSGPGALGGVFVHERHH-GLHRFEGWWSTAAATRFEMT-PVSR-PAVEAWQISNPPIFAMGPVRTSLELFDSVGMPALR-RSLRLTGYLERLL-VVA-LTVVTPRDPSRRGCQLSVRIGV-TAN----ELKRGVIADARQPDVVRFAPVPLYSTYHDCWRVA-ALAATVE
Winogradskyella_psychrotolerans_527071721     M-LFQEK-PYK-LQD-LDELSQYRTQFHIPK--D---------K-HGNIYLCGNSLGLQPKSTKDYINQELEDWANLGVEGH-DAKNPWLPYHEFLAEA---LVGAKP-EVVTMNSLTANLHFMMASFYKPTKERYKILIESDAFPSDKYAVESQLRHHGYDDKEGL-LWKPREGEELLNYED-LE-ILKTGNEIALIMIGGVNYYTGQFFDFKRITDLGHSYGCKVGFDCAHGAGNVNLDLHNSGADFAVWCTYKYMNSGPGSLSGCFVHERHAYD-DLFTGWWSHNKDTRFNMRHEFDVLPGAEGWQLSNPPILSMAAIKASLDMFNEVGIDKIIKKSKKLTGYFEFLL-D-LDIRIITPENPDERGCQLSIQVLKADKS-LHDKLEAGVISDWREPDVIRCAPVPLYNSFEDVYLMVEK-KE-LK
Xanthomonas_albilineans_285018529             -------MPRQ-M-DAADPLFALRQEFLFPQHQ----------GADQ-AYFVGNSLGLQPRGARAAVQEVLDTWSAVAVEGHFNGATQWMSYHELLAA-LARLVGAQP-EVVAMNTLTVNLHLLMVSFYRPTRARPAILIEAGAFPSDRHAVASQIRFHG--FDPAT-LIEVQ-G--TVSLEAIAR-IGE-APRLALVLWPGVQYRTGQAFDLAAIAQLARKAGAALGFDLAHAIGNLPLHLHDIAPDFAVWCHYKYLNAGPGAIAGAFVHERHGHG-PRFAGWWGHDKRSRFQMEPDFVAAPGADGWQLGNPPILSMAPLRASLELFERAGMPALRHKSQQLTGYLEMLI-HALNLEILTPSDPAQRGCQLSLRVVARGRS-LLEYLSVGVLGDWREPDVIRISPVPLYNQYHDVYRFIEA-EA---
Xanthomonas_arboricola_515423494              --MIMDRA----V-DAADPLRHLREDFVFP--QH--------AGQDQT-YFVGNSLGLQPRGARAMVAEVLDQWGALAVEGHFTGPTQWLTYHQ-LVR-AR-VVGAQP-EVVAMNTLSVNLHLMMASFYRPTPERGAILIEAGAFPSDRHAVESQLRLHGL--DPAT-LIEV--ADQTVSMAAIAD-IAR-GPRLALVLWPGIQYRTGQAFELGEIARLARAQGAMVGFDLAHAVGNIALTLHDDGADFAVWCHYKYLNAGPGAVGGCFVHARHANS-PRMAGWWGHEQQSRFRMEP--QFVPGAEGWQLSNPPVLAVAPLRASLELFDQAGMPALRAKSEQLTGHLEQLI-H-RQLQIVTPAAPAQRGCQLSLRVAAQGRS-LFEYLSVGVLGDWREPDVIRIAPVPLYNRFSDLHRLVEQ-ET--S
Xanthomonas_fragariae_488893332               IDPLS-RS----A-DVADPLRSLRDDFVFP--Q----------HGDQETYLVGHSLGLQPRATRAMVAEVLDQWGALGVEGHFTGPTQWLTYHQ-LVR-AR-VVGALP-EVVAMNALSVNLHLMMVSFYRPTPQRGAILIEAGAFPSDRHAVESQLRLHGL--DPAT-LIEV--ADETLSMAAITD-IAQ-GPRLALVLWPGVQYRTGQAFDLGEIVRLARAQGAAVGLDLAHAVGNLPLTLHDDGVDFAVWCHYKYLNAGPGAVGGCFVHQRHAHS-PRMAGWWGHAQQTRFRMDP--QFVPGAEGWQLSNPPVLALAPLRASLELFDHAGMAALRTKSEQLTGYLEQLI-H-RQLQIVTPAEPSQRGCQLSLRVAAQGRS-LFEYLSVGVLGDWREPDVIRIAPVPLYNRFCDLHQFVEH-ET--A
Xanthomonas_oryzae_84623962                   ----MDRA----D-DAADPLRSLRDAFVFPQHGD----------RDQT-YLVGNSLGLQPRAARAMVDEVLDQWGTLGVEGHFTGPTQWLTYHQ-LVR-AR-VVGAQP-EVVAMNTLSVNLHLMMASFYRPTHERGAILIEAGAFPSDRHAVESQLRLRGL--DPAT-LIEV--ADETLSMAAIAD-IAQ-GPRLALVLWPGIQYRTGQAFDLAEIVRLARAQGAAVGCDLAHAVGNIPLTLHDDGVDFAVWCNYKYLNAGPGAVGGCFVHERHANS-PRIAGWWGHEQQTRFRMDP--QFVPGAEGWQLSNPPVLALAPLRASLALFDQTGMAALRAKSERLTGHLEQLI-H-RQLQIVTPAEPMRRGCQLSLRVAAQGCS-LFEHLAAGVLGDWREPDLIRIAPVPLYNRFSDLHTFVGQ-EA--A
Xenopus_tropicalis_301615894                  M----------L--DDQDELKHLRQCFHVPKIKDIPTTDKSLVNEEDDVYLCGNSLGLLPKTVK-YIDEELDKWAKMGVHGHFTGK-PWALC-ECI---MA-IVGARKEEVALMNGLSVNLHLQMLSFYRPTKDRYKILLEAKAFPSDHYAVESQIRLH----GKSMLLLY--K-ED-LRTE-ILSVIEEDGDSIAVILFSGVQYYTGQLFDMEKI--AG-KKGCFVGFDLAHAVGNVELHLHDWGVDFACWCSYKYLNSGAGGLAG-FLHKKH-NTIPTLMGWWGHDFKTRFKMENEMELSPGINGFRISNPPILLVCSLHASLEVFNQTTMKALRKKSILLTGYLEQL-KY-YFAKILTPSNVKERGCQLSLTFSLPIKA-VFEELKRGVVCDMREPHGLRIAPVPLYNTFHDVYRFIQILG---E
Yarrowia_lipolytica_50547545                  -----------------MPL-NFRDRFNVP-------VL---KNGE---YLVGNSLGLMPHKTRDYVNQEMDAWSQLGV-GHFVGQG-WYSCDEP-HGLVGPILGAS-DEVAIMNTLTSNIHSLF-AFYKPTAKRSKILFEAKAFPSDTYAMEAQARLH----DPSEALIKPKD-LH-LSDDDIIK-IEEQGDEIAVVFFSGIQFYTGQLFDIPRIT-AA-AKGCVVGWDLAHAAGNVPLKLHDWNVDFAVFCTYKYMNSGPGGIGG-FVHDKYADD-PRLAGWWGNNAETRFKMLDEFDP--GARGYKQSNP-VLCVL-LRASLELFKEAGIE-LRERSIELTNRL----PENFGFTIITPQAE-QRGAQLSLLF--GDKK-VFDYLD-GVLGDERNPDVIRLAPAPLYNNERDVDLAINDSINLIN
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