#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 18, 2025; 21:22 GMT TreeBASE (cc) 1994-2008 Study reference: Watanabe H., Schmidt H.A., Kuhn A., Höger S.K., Kocagöz Y., Laumann-lipp N., Özbek S., & Holstein T.W. 2014. Nodal signalling determines biradial asymmetry in Hydra. Nature, . TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S16190] BEGIN TAXA; TITLE Untitled_Taxa_Block; DIMENSIONS NTAX=162; TAXLABELS Acropora_digitifera_Activin_1 Acropora_digitifera_Activin_2 'Acropora digitifera Bmp2/4' 'Acropora digitifera Gdf5-like' 'Acropora digitifera Nodal-related A' Acropora_digitifera_Tgf2 Acropora_digitifera_Tgf3 Acropora_digitifera_Tgf4 Acropora_millepora_Activin_1 Acropora_millepora_Activin_2 'Acropora millepora Bmp2/4' 'Acropora millepora Gdf5-like' 'Acropora millepora Nodal-related A' 'Acropora millepora Nodal-related B' Acropora_millepora_Tgf1 Acropora_millepora_Tgf2 Acropora_millepora_Tgf3 Acropora_millepora_Tgf4 Acropora_millepora_Tgf5 Biomphalaria_glabrata_Nodal Branchiostoma_floridae_Activin Branchiostoma_floridae_Admp 'Branchiostoma floridae Bmp2/4' Branchiostoma_floridae_Bmp3 'Branchiostoma floridae Bmp5-8' 'Branchiostoma floridae Gdf5-7' 'Branchiostoma floridae Gdf8/Tgfb-like' Branchiostoma_floridae_Lefty Branchiostoma_floridae_Myostatin Branchiostoma_floridae_Nodal 'Branchiostoma floridae Nodal-related' Branchiostoma_floridae_Tgf1 Branchiostoma_floridae_Univin 'Cladonema pacificum Bmp2/4' 'Cladonema pacificum Bmp5-8' 'Cladonema pacificum Gdf8/Tgfb-like' 'Cladonema pacificum Nodal-related' Danio_rerio_Admp Danio_rerio_Bmp10 Danio_rerio_Bmp2a Danio_rerio_Bmp3 Danio_rerio_Bmp4 Danio_rerio_Bmp5 Danio_rerio_Bmp6 Danio_rerio_Bmp7 Danio_rerio_Gdf11 Danio_rerio_Gdf5 Danio_rerio_Gdf6A Danio_rerio_Gdf7 Danio_rerio_Gdf8 Danio_rerio_InhibinbA Danio_rerio_Lefty1 'Danio rerio Nodal-related' Danio_rerio_Tgfb2 Danio_rerio_Tgfb3 Danio_rerio_Vgr1 Drosophila_melanogaster_Dpp Drosophila_melanogaster_Myoglianin Gallus_gallus_Nodal 'Hydra magnipapillata Activin-like 1' 'Hydra magnipapillata Activin-like 2' 'Hydra magnipapillata Activin-like 3' 'Hydra magnipapillata Activin-like 4' 'Hydra magnipapillata Bmp2/4' 'Hydra magnipapillata Bmp5-8a' 'Hydra magnipapillata Bmp5-8b' 'Hydra magnipapillata Bmp5-8c' 'Hydra magnipapillata Nodal-related' Hydra_magnipapillata_Tgf1 Hydra_magnipapillata_Tgf2 Hydra_magnipapillata_Tgf3 Hydra_magnipapillata_Tgf4 Lottia_gigantea_Admp 'Lottia gigantea Bmp2/4' 'Lottia gigantea Bmp5-8' Lottia_gigantea_Myostatin Lottia_gigantea_Nodal Lottia_gigantea_Tgf1 Lottia_gigantea_Tgf2 Lottia_gigantea_Tgf3 Lymnaea_stagnalis_Nodal Mnemiopsis_leidyi_Myostatin 'Mnemiopsis leidyi Nodal-related' Mnemiopsis_leidyi_Tgf1a Mnemiopsis_leidyi_Tgf1b Mnemiopsis_leidyi_Tgf2 Mnemiopsis_leidyi_Tgf3 Mnemiopsis_leidyi_Tgf4 Mnemiopsis_leidyi_TgfbA Mus_musculus_Bmp10 Mus_musculus_Bmp2 Mus_musculus_Bmp3 Mus_musculus_Bmp4 Mus_musculus_Bmp5 Mus_musculus_Bmp6 Mus_musculus_Bmp7 Mus_musculus_Gdf1 Mus_musculus_Gdf11 Mus_musculus_Gdf3 Mus_musculus_Gdf5 Mus_musculus_Gdf6 Mus_musculus_Gdf7 Mus_musculus_Gdf8 Mus_musculus_InhibinbA Mus_musculus_InhibinbB Mus_musculus_Lefty1 Mus_musculus_Nodal Mus_musculus_Tgfb1 Mus_musculus_Tgfb2 Mus_musculus_Tgfb3 Nematostella_vectensis_Activin 'Nematostella vectensis Bmp2/4' 'Nematostella vectensis Bmp5-8' 'Nematostella vectensis Gdf5-like' Nematostella_vectensis_Gdf8 'Oscarella carmela Activin-like' Oscarella_carmela_Tgf1 Oscarella_carmela_Tgf2 Oscarella_carmela_Tgf3 Oscarella_carmela_Tgfb1 Oscarella_carmela_Tgfb2 'Saccoglossus kowalevskii Activin-like' Saccoglossus_kowalevskii_Admp 'Saccoglossus kowalevskii Bmp10-like' 'Saccoglossus kowalevskii Bmp2/4' 'Saccoglossus kowalevskii Bmp3-like' 'Saccoglossus kowalevskii Bmp5-8' 'Saccoglossus kowalevskii Gdf8/11-like' Saccoglossus_kowalevskii_Lefty Saccoglossus_kowalevskii_NodalA Saccoglossus_kowalevskii_Tgfb2 'Saccoglossus kowalevskii Univin-like' 'Strongylocentrotus purpuratus Bmp2/4' Strongylocentrotus_purpuratus_Bmp3 Strongylocentrotus_purpuratus_Lefty Strongylocentrotus_purpuratus_Nodal Strongylocentrotus_purpuratus_Univin Tribolium_castaneum_Activin Tribolium_castaneum_Gdf8 Xenopus_laevis_Admp Xenopus_laevis_Bmp2 Xenopus_laevis_Bmp3 Xenopus_laevis_Bmp4 Xenopus_laevis_Bmp6 Xenopus_laevis_Bmp7 Xenopus_laevis_Derriere Xenopus_laevis_Gdf6 Xenopus_laevis_Gdf7 Xenopus_laevis_InhibinbB Xenopus_laevis_InhibinbC Xenopus_laevis_Lefty Xenopus_laevis_Ndr1 Xenopus_laevis_Ndr2A Xenopus_laevis_Tgfb1 Xenopus_laevis_Tgfb2 'Xenopus laevis Vg-1' 'Xenopus tropicalis Bmp10-like' 'Xenopus tropicalis Bmp5-like' 'Xenopus tropicalis Gdf11-like' Xenopus_tropicalis_Gdf5 Xenopus_tropicalis_Gdf6 'Xenopus tropicalis Gdf8-like' ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M23497] TITLE 'Tgf-beta gene superfamily alignment'; LINK TAXA = Untitled_Taxa_Block; DIMENSIONS NCHAR=165; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 ] [ . . . . . . . . . . . . . . . . ] Acropora_digitifera_Activin_1 QQECCRRKLYVNF-TAQRW-D--WIIHP-SGFSANYCDGRCQKPNISLTPEK---LSKHKTV------------P-I--K------N-ESICCSPS--KYSPFSMMF-YDG---TS---FR----KI-DMTEMKIEACS------------------------CS Acropora_digitifera_Activin_2 QQECCRRMLYVNF-KKIGW-D--WIIFP-EGFHANFCDGTCNGIVD--P------FYSYPYLLQE---VSRAN-K-Q--E------R-VSICCTPT--KMSAISVLH-FNDD--ER---VM----KI-DVPNMRVDACG------------------------CF 'Acropora digitifera Bmp2/4' VNYCQRHPLYVDF-SEVGWND--WIVAP-PGYQGFYCKGECPFPIA--DHLN---TTNHAIVQTLM--NSVN--P-N--N------V-PPACCVPT--TLDAISMLF-MNEH--SK---VV----LK-NYQDMVVDGCG------------------------CR 'Acropora digitifera Gdf5-like' KDSCRRKPMHVDF-KQLGWSN--WVIAP-RGYSAYLCEGLCEFPID--DYLK---PTNHATVQTIL--NSVA--P-T--L------A-PRACCSPN--KFSAISILY-IDKG---N---II----YK-KYEDMVVERCG------------------------CK 'Acropora digitifera Nodal-related A' PSPCSRKDMMITS-SDFGKRDGLTLLHP-RVFNAYQCSGECSFKE----------KTNNSKLRALI--MRDNGHSIR---------E-SKSCCVPS--KLRSIVVMQ-RTAE--RN---YL----IS-TLKNMIVESCT------------------------CY Acropora_digitifera_Tgf2 VDRCSRRKLFVKF-RDLKFDK--WIIAP-RGFSAYYCVGTCPEIID--KGYS---PTNHAIIQNLL--HHRI--N-K--N------I-PAACCVPT--SLHSISMMY-FELD--GS---IV----LR-EYSGMVASTCG------------------------CR Acropora_digitifera_Tgf3 HKECRRRWVYVQF-KKLRWN---WIIAP-SGYSANYCEGACSSVLH--IALE---PTNHAILQNIL--HRMD----N--R------I-PSPSCVPT--KLHGISILY-RASD--RS---IA----LT-EYGGMVVSTCG------------------------CH Acropora_digitifera_Tgf4 AGKCGVRNLTIYF-KDLGWDK--WFIAP-KMYSSNYCGGTCLDRHN--TQI----MSNHALVQLLV--HEKD--S-S--S------A-HAPCCVPN--SMSALSMLY-FGDSGQST---TK----KT-AYENARLSS---------------------------- Acropora_millepora_Activin_1 QQECCRRKLYVNF-TAQSW-H--WIIHP-SGFSANYCDGRCQKPNISLTREK---LSKHRTV------------P-I--K------N-ESICCSPS--KYSPFSMMF-YDG---TS---FR----KI-DMTEMKIEACS------------------------C- Acropora_millepora_Activin_2 QQECCRRMLYVNF-KKIGW-D--WIIFP-EGFHANFCDGTCNGIVD--P------FYSYPYLLQE---VSRAN-K-Q--E------R-VSICCTPT--KMSAISVLH-FNDD--ER---VM----KI-DVPNMRVDACG------------------------C- 'Acropora millepora Bmp2/4' VNYCQRHPLYVDF-SEVGWND--WIVAP-PGYQGFYCKGECPFPIA--DHLN---TTNHAIVQTLM--NSVN--P-N--N------V-PPACCVPT--TLEAISMLF-MNEH--SK---VV----LK-NYQDMVVDGCG------------------------CR 'Acropora millepora Gdf5-like' KDSCRRKPMHVDF-KQLGWSN--WVIAP-RGYSAYLCEGLCEFPID--DYLK---PTNHATVQTIL--NSVA--P-T--L------A-PRACCSPN--KFSAISILY-IDKG---N---II----YK-KYEDMVVERCG------------------------CK 'Acropora millepora Nodal-related A' PSPCSRKDMMITS-SDFGKRDGLTLLHP-RVFNAYQCSGECSFKE----------KTNNSKLRALI--MRDNGHSIR---------E-SKSCCVPS--KLRSIVMMQ-RTAE--RN---YL----IS-TLKNMIVESCT------------------------C- 'Acropora millepora Nodal-related B' GP-CSRRPMTVHF-RAHLNMK--QVIFP-RTFESYRCGGSCKFPLD----VN---PTRHAIILAIL--YSRS-GRAG--G------G-KEPCCVPI--KLRKMTVFA-RRE---GH---IK----IQ-TFQDMIVEECG------------------------CR Acropora_millepora_Tgf1 LDICRKRRHAVRF-RDLKWNG--WIIAP-TRFGFHYCEGICSATLS--QEYN---PSNHAILQNIL--HHRL--T-S--E------I-PAATCVPI--ELHSMSLLY-YDTD--NT---IV----LR-EVPEMVASNCG------------------------CR Acropora_millepora_Tgf2 VDRCSRRKLFVKF-RDLRFDK--WIIAP-RGFSAYYCVGTCPEIID--KGYS---PTNHAIIQNLL--HHRI--N-K--N------I-PAACCVPT--SLHSISMMY-FELD--GS---IV----LR-EYSGMVASTCG------------------------CR Acropora_millepora_Tgf3 HKECRRRWVYVQF-KKLRWN---WIIAP-SGYSANYCEGACSSVLH--IALE---PTNHAILQNIL--HRMD----N--R------I-PSPSCVPT--KLHGISILY-RASD--RS---IA----LT-EYGGMVVSTCG------------------------C- Acropora_millepora_Tgf4 AGKCGVRNLTIYF-KDLGWDK--WFIAP-KMYSSNYCGGTCLDRHN--TQI----MSNHALVQLLV--HEKD--S-S--S------A-HAPCCVPN--SMSALSMLY-FGDSGQST---YV----LK-TVDGFIVRSCA------------------------CR Acropora_millepora_Tgf5 DSQCRLQTFVSNF-SMIGMGY--MIISPRNPIRFAYCRGSCDMPFS--LDAG---DDSYVTADMLI--RHLAILNGLSLSDDEKDMF-KTSYCVPV--EYTSLRVVF-GTEK--G----VR----KK-LWIRAIPRKCG------------------------CR Biomphalaria_glabrata_Nodal KVNCQLHNFEVDF-NTIGWGQ--WIIHP-KKYNAQFCFGVCPSPVD--SKYK---PTNHAMLQTLM--RLKR--P-N--V------A-PAPCCVPT--RLNPLSMMY-YEF---NE---LV----VR-HHEDMIATECG------------------------CR Branchiostoma_floridae_Activin SNECCREKFYVDF-KDIAWDD--WIISP-KGYYANFCTGSCQGTIL--P------RYHHTSVLQRV--ALSQKDR-ETRL------K-LTPCCTPT--KMSALSMLY-FDND--GY---IF----NK-NLPNMKVDACG------------------------CS Branchiostoma_floridae_Admp FEPCTRRNLYVDF-DAIGWSG--WIISP-KGYNAYHCKGKCPFPLG--QSQK---PTNHATVQSIM--NALRL-Q-E--D------V-GQPCCVPN--KLYSINLLY-FDDE--EN---VI----LK-QYDDMVAANCG------------------------CH 'Branchiostoma floridae Bmp2/4' KANCRRHSLYVDF-SDVGWND--WIVAP-PGYQAYYCHGECPFPLA--DHLN---STNHAIVQTLV--NSVN--P-L--A------V-PKACCVPT--DLSPISMLY-LNEN--DQ---VV----LK-NYQDMVVEGCG------------------------CR Branchiostoma_floridae_Bmp3 --------MRVDF-ADIGWSD--WIISP-KAFDAYYCAGTCDFPMS--KVMK---PSNHATIQSIM--RTVGI-T-S--G------V-PSPCCVPD--KLSSLSILY-FDEN--RN---VV----LK-VYPNMSVESCA------------------------CR 'Branchiostoma floridae Bmp5-8' PHVCQRRSLYVSF-RDLGWQD--WIIAP-DGYAAYYCFGECSFPLN--ALMN---ATNHAIVQTLV--HLMN--P-Q--H------V-PKPCCAPI--KLSAISVLY-FDES--SN---VI----LK-KYRNMVVKSCG------------------------CH 'Branchiostoma floridae Gdf5-7' ---CMRRSLQVSF-HDLGWDD--WIIAP-TNYDAHYCAGACSFPLR--SHLE---PTNHAIVQTLV--NSMN--P-R--A------V-EKVCCVPT--KLSPISILY-IDGK--DT---VV----YK-KYDDMVADQCG------------------------CR 'Branchiostoma floridae Gdf8/Tgfb-like' PRSCCRRSLVVSF-KDIGWDG--WVMEP-AEFDAHYCLGQCASYNL---------PSPHAAIMDQV----VS--P-V--Y------E-MKPCCVPVPGQMRDLLIRYSFDGG--KT---IS----TQ-HIPNIIVNTCG------------------------CL Branchiostoma_floridae_Lefty SNRCCRSENYIDF-SDLPFAEQ-FILEP-RGYDAFQCGGGCPKRA----------RW-YMHNDPEQ----------------------LQQTCGVV--RTAPLPVMY-LVSR--GDKTEIE----VA-DFPNMIVEQCA------------------------CT Branchiostoma_floridae_Myostatin EERCCRYPLQVDF-REFGW-D--WIIAP-NTYQAYYCAGDCPPIFL-----Q---KYPHTHLVQQV--NK--A------G------S-VGPCCTPT--KMSNISMLY-FDDD--GN---II----YA-KLPDMKVDRCG------------------------CS Branchiostoma_floridae_Nodal TP-CKKVEFWVDF-DHIGWGT--WIIYP-KRFNAFRCEGVCPTPVD--QLYH---PTNHAVMTSIL--NLHK--P-G--K------A-PMPCCIPT--KLKALSMLY-LEH---GE---VV----LR-HHEDMIVDECG------------------------CQ 'Branchiostoma floridae Nodal-related' VEECRRHDYHVVF-DDIILPE--FILQP-PRFNAYRCGGACTRPFP--SHMN---ATNHAMLMSLL--HERT--PHK---------V-PAPCCVPL--AYSAISVME-QHG---DN---IV----VK-PYPNMRVETCG------------------------CR Branchiostoma_floridae_Tgf1 CKSCKRHSLYVDF-TELGWG---WIIAP-AGYTAYYCKGHCPPIMG--QHLR---PTNHAVVQNIM--GTLH--P----R------V-PPARCVPG--MLRPISVLH-YEEN--GS---II----YK-EYPDMVAMSCA------------------------CR Branchiostoma_floridae_Univin GNICKRRKLYIRF-KDVGWDD--WIIAP-QGYMAYHCSGECPFPLN--EHLN---GTNHAVIQTLV--NSLT--P-D--S------V-PPACCAPT--KWSSISMLY-FDNN--GD---VV----LR-QYEDMVVDGCG------------------------CR 'Cladonema pacificum Bmp2/4' KEKCRLRNFFLDF-KDVAWDE--WIIAP-TGYYINYCHGVCPKPLG--PHYN---TTNHAVIQNSV--SNIN--R-N--L------V-PPLCCIPT--TLKDQTFLY-LDDH--GS---LI----IK-NPIDMVAMGCG------------------------CH 'Cladonema pacificum Bmp5-8' NASCGRRPLYIGF-KDLGWND--WILAP-AGYRAAYCDGECGFPLH--DKMN---ASNHAIIQTLV--HMIN--P-D--H------I-PQPCCAPV--RLEPLKVLY-LDER--SN---II----MK-TYGNMIVKHCG------------------------CQ 'Cladonema pacificum Gdf8/Tgfb-like' SSDCCLDNFYVSF-KAIGD----WIRNP-VGYNAQQCRGRCNS-----RHPK---SNPHRSMVSAI--STRRNIT----D------D-IKFCCTTQ--AYAPLKISY-QDFE--GN---IV----HQ-SLTNMIATQCG------------------------CG 'Cladonema pacificum Nodal-related' KKMCRRKNMVVDF-QELGWGN--WLLSP-TKYNAYHCHGHCRYPLA--TYLR---PTNHATIQSIV--HNMN--R-D--F------V-PSACCVPT--DFDVLPILS-LDGK--DR---VV----FK-LKSGLVATNCG------------------------CR Danio_rerio_Admp KMACQRQPLYVDF-EEIGWSG--WIVSP-KGYNAYHCKGSCIFPLS--QNMR---PTNHAIVQSII--NTLKL-N-K--G------I-QTPCCVPD--KLYSISLLY-FDDD--EN---VV----LK-QYDDMVAGSCG------------------------CR Danio_rerio_Bmp10 GNQCKKSSLYVDF-KDIGWDS--WILAP-TGYEAFECTGVCTYPLT--KDVT---PTKHAVIQTLV--SLKS--P-Q--V------V-SRACCVPT--ELDPISLLY-LDDA--GV---VT----YQYKFEGMVVAKCG------------------------CR Danio_rerio_Bmp2a KANCRRHSLYVDF-SDVGWND--WIVAP-PGYHAFYCQGECPFPLA--DHLN---STNHAIVQTLV--NSVN----S--N------I-PRACCVPT--DLSPVSLLY-LDEY--ER---VI----LK-NYQDMVVEGCG------------------------CR Danio_rerio_Bmp3 PRNCARRYLKVDF-ADIGWSE--WIISP-KSFDAYYCSGSCQFPMP--KSLK---PSNHATIQSIV--RAVGV-V-P--G------I-PEPCCVPE--KMSSLSILF-FDED--KN---VV----LK-VYPNMTVDSCA------------------------CR Danio_rerio_Bmp4 NRNCRRHALYVDF-SDVGWND--WIVAP-PGYQAYYCHGECPFPLA--DHLN---STNHAIVQTLV--NSVN----T--N------I-PKACCVPT--ELSAISMLY-LDET--DR---VV----LK-NYQEMVVEGCG------------------------CR Danio_rerio_Bmp5 RQACKKHELYVSF-RDLGWQD--WIIAP-EGYAAFYCDGECSFPLN--AHMN---ATNHAIVQTLV--HLMF--P-D--N------V-PKPCCAPT--KLNAISVLY-FDDS--SN---VI----LK-KYRNMVVRSCG------------------------CH Danio_rerio_Bmp6 KTACRKHDLYVSF-RELSWQD--WIIAP-EGYAANYCDGECSFPLN--AHMN---ATNHAIVQTLV--HLMN--P-E--N------V-PKPCCAPT--KLHAISVLY-YDDN--SN---VI----LK-KYRNMVVRSCG------------------------CH Danio_rerio_Bmp7 KQACKKHELYVSF-RDLGWQD--WIIAP-EGYAAYYCMGECAFPLN--SYMN---ATNHAIVQTLV--HFIN--P-E--T------V-PKPCCAPT--QLHAISVLY-FDDS--SN---VI----LK-KYRNMVVRACG------------------------CH Danio_rerio_Gdf11 ESRCCRYPLTVDF-EAFGW-D--WIIAP-KRYKANYCSGQCEYMFM-----Q---KYPHTHLVQHA-------NP-R--G------S-AGPCCTPT--KMSPINMLY-FNDK--QQ---II----HG-KIPGMVVDRCG------------------------CS Danio_rerio_Gdf5 KQRCNRKQLHVNF-KEMGWDD--WIIAP-LEYEAFHCDGVCDFPIR--SHLE---PTNHAIIQTLM--NSMD--P-R--S------T-PPTCCVPT--RLSPISILY-IDSA--NN---VV----YK-QYEDMVVESCG------------------------CR Danio_rerio_Gdf6A KSRCSKKALHVNF-KELGWDD--WIIAP-LDYEAYHCEGVCDFPLR--SHLE---PTNHAIIQTLM--NSMD--P-N--S------T-PPSCCVPT--KLSPISILY-IDSG--NN---VV----YK-QYEDMVVEQCG------------------------CR Danio_rerio_Gdf7 RTRCSRKPLHVNF-KELGWDD--WIIAP-LDYEAYHCEGLCDFPLR--SHLE---PTNHAIIQTLM--NSMD--P-E--S------T-PPSCCVPS--KLSPISILY-IDSG--NN---VV----YK-QYEDMVVESCG------------------------CR Danio_rerio_Gdf8 ESRCCRYPLTVDF-EDFGW-D--WIIAP-KRYKANYCSGECDYMYL-----Q---KYPHTHLVNKA-------SP-R--G------T-AGPCCTPT--KMSPINMLY-FNGK--EQ---II----YG-KIPSMVVDRCG------------------------CS Danio_rerio_InhibinbA ARVCCKRQFYVNF-KDIGWND--WIIAP-SGYHANYCEGDCASNVASITGNS---LSFHSTVISHY--RIRGYSP-F--T------N-IKSCCVPT--RLRAMSMLY-YNEE--QK---IV----KK-DIQNMIVEECG------------------------CS Danio_rerio_Lefty1 REMCCREQYFINF-RALTWTQY-WIIEP-SGYQAFRCKGGCRQPK----------R-N-YGY--------------------------GERKCAVV--ESAPLPMMY-LVKK--GDYTEIE----VA-EFPNMIVEKCG------------------------CA 'Danio rerio Nodal-related' KPLCKKVDMWVDF-DQIGWSD--WIVYP-KRYNAYRCEGSCPTPVD--ETFT---PTNHAYMQSLL--KLHH--P-D--R------V-PCLSCVPT--RLAPLSMLY-YEN---GK---MV----MR-HHEGMVVAECG------------------------CH Danio_rerio_Tgfb2 QDNRCLRSLYIDFKKDLGWR---WIHEP-KGYNANFCAGACPYLWS-----A---DTQHSNILGLY--NTIN--P-E--A------S-ASPCCVSQ--DLEPLTILY-YIGK--TP----K----IE-QLSNMIVKSCK------------------------CS Danio_rerio_Tgfb3 EENCCVRKLYIDFRQDLGWR---WIHEP-KGYHANFCSGPCPYLRS-----A---DTTHSSLLSLY--NTLN--P-E--A------S-ASPCCVPQ--DLEPLTILY-YVGR--TP----K----VE-QLSNMIVKSCK------------------------CS Danio_rerio_Vgr1 SNVCKPRRLYIDF-KDVGWQD--WIIAP-QGYLANYCHGECPFPLS--ESLN---GTNHAILQTLV--HSFD--P-K--G------T-PQPCCVPI--KLSPISMLY-YDNN--DN---VV----LR-HYEDMVVDECG------------------------CR Drosophila_melanogaster_Dpp DDTCRRHSLYVDF-SDVGWDD--WIVAP-LGYDAYYCHGKCPFPLA--DHFN---STNHAVVQTLV--NNMN--P-G--K------V-PKACCVPT--QLDSVAMLY-LNDQ--ST---VV----LK-NYQEMTVVGCG------------------------CR Drosophila_melanogaster_Myoglianin DMRCCRYPLKVNF-TSFGWH---FVVAP-TSFDAYFCSGDCKVGYL-----E---QYPHTHLAALT-------------T------S-ATPCCSPT--KMSSLSLLY-FDDN--HN---LV----LS-VIPNMSVEGCS------------------------CS Gallus_gallus_Nodal RSLCRRVDMMVDF-EQTGWGS--WIVYP-KKYNAYRCEGLCPSPVD--ESFK---PTNHAYMQSLL--QLYK--P-S--Q------V-PCPACSPI--RMSPLSMLY-YEK---GE---IV----VR-HHEDMIIEECG------------------------CN 'Hydra magnipapillata Activin-like 1' SEECCRSSITINF-KDLGWES--WILAP-KTYEAYYCTGTCKENSN----------TNPPHFQLLR--SNNN----------------KGKCCVPK--SMSSLAILY-VGSE--G----II----KK-DLPNMIVDECW------------------------CI 'Hydra magnipapillata Activin-like 2' DASCCSRPVYVSF-EDLSWN---WVLSP-KGFWTNKCMGNCKDNKQ----------------------------------------G-INNCCIPI--EHESITMFY-YDND--YI---FY----AK-KVNNIVTKECG------------------------CR 'Hydra magnipapillata Activin-like 3' DASCCSRPFYVSF-QDLKWN---WVLSP-KGFWTNKCMGKCKDGNL----------------------------------------N-NSGCCAPK--SFGSITMFY-HNGD--YI---LY----GK-KIENIVTKDCG------------------------CL 'Hydra magnipapillata Activin-like 4' SVSCCSRPVYISF-EDINWR---WVLSP-KGFWTNKCMGKCDKENP----------------------------------------D-KSTCCAPL--TLGSITMYY-HNGD--YL---VY----GK-KLENIVIKDCG------------------------CQ 'Hydra magnipapillata Bmp2/4' QDLCHLHPFEFDL-VKVGWNE--FVLYP-SLYRLNFCAGKCPNPLS--HHFN---GTNHAVIQNNV--LKIA--K-D--K------V-PPLCCIPS--ELEAQTIIY-IDHE--NK---MI----IK-RPEKMIATACG------------------------CR 'Hydra magnipapillata Bmp5-8a' ISDCGKHLLYVSF-KDIGWSD--WIIAP-DGYITSYCGGDCSFPLE--SNLN---ATNHAILQALV--HTIF--P-K--K------I-PKPCCAPN--KLNAMSILF-FDDR--NN---VV----MQ-EIPNMIVHQCG------------------------CQ 'Hydra magnipapillata Bmp5-8b' GSRCDKHSLYIRF-KDIGWN---LIIAP-EGYEANYCGGECSFPLD--NNAS---ATNHATIQTLV--HMMF--P-E--I------I-PKPCCAPN--KLKRLKVLF-EDER--HN---VV----LS-HFPNMIVQHCG------------------------CQ 'Hydra magnipapillata Bmp5-8c' GSRCDKHPLYIGF-KDLGWSD--WIIAP-DGYRANYCGGDCSFPLD--NNAN---ATNHAIIQTLV--HMMY--P-E--I------I-PKPCCAPN--KLNTLQVLF-LDER--NN---VV----MK-RYSNMIVQHCG------------------------CQ 'Hydra magnipapillata Nodal-related' K-KCRRKSMKVNL-SELKWDK--WFMNP-IKFNAYYCHGSCAHPL---T-VT---TDNHATIQSMM--HKLN--T-K--I------V-GPPCCVPT--EYEKLLVLY-MQE---NN---PT----IR-LINGLIVKACG------------------------CK Hydra_magnipapillata_Tgf1 NVGCRKKNMFFKF-RDYSEFS--NVLIP-KKANFYRCVGSCTIPFGKNSKIM---KSTRAFIQELI--SSRQ-KGVK--P------M-HLPTCSPS--SLKPMKYII-FEN---EK---VK----IG-SWDDAVVSECWSITIIFMFINHNDVIYLFQYMSISCK Hydra_magnipapillata_Tgf2 KNICSVKQLFVPL-KKAGWNN--LFLYP-DHFIINQCKGQCYIK-----------KTYHSILQTLY--ADVL--KNH--E------V-KHPCCAPS--KLLPGTALI-YDHS--SGKKVFN----LV-RIHNLTVTQCE------------------------CL Hydra_magnipapillata_Tgf3 SKLCGVEPLVVPL-ELIDWHN--LFIMP-KSFSINQCKGRCFHKND-EDYLG---QTSHSILQALY--ADVL--QDD--N------V-NYPCCAPT--KFLPASAIL-NDRS--SNREVYK----LV-QLENLQVTECE------------------------CL Hydra_magnipapillata_Tgf4 AKVCGVEPLNVPL-ELIDWQK--LFIYP-THFIINHCKGFCYHKND--KDNDE--QTSHSILQALY--ADVL--QND--I------V-KYPCCAPT--KFLPGTALI-IDRS--SVNEVIK----LV-QLENLTVTECK------------------------CL Lottia_gigantea_Admp KRSCTKQDMYVDF-DEIGWSG--WIISP-KGYNANHCTGTCPFPLG--QSQK---PTNHATVQSIV--YALGV-G-K--S------V-ETPCCVPN--KLYSISLLY-FDDD--EN---VI----LK-QYDDMVAATCG------------------------CH 'Lottia gigantea Bmp2/4' KNECKRHALYVDF-GDVGWND--WIVAP-TGYNAYFCRGECPFPMG--QHLN---STHHAVMQTLV--HSVN--P-S--A------V-PKACCVPS--ELSAISMLY-LDEW--DK---VV----LK-NYQDMVVEGCG------------------------CR 'Lottia gigantea Bmp5-8' NLPCKRHSLYVSF-RDLGWQD--WIIAP-DGYSAFYCHGECSFPLA--ANMN---ATNHAIVQTLV--HLMD--P-V--L------V-PKPCCAPT--KLNAISVLY-FDAN--SN---VV----LK-KYKSMIVKSCG------------------------CH Lottia_gigantea_Myostatin EKRCCRHPLEVDF-VDFGWD---WVIAP-IRYKAGYCNGECDSTYQ-----D---EYAHTYLRQRA--SLTS----------------DGPCCTPT--QHKPLSLLY-FDHD--QN---IL----FT-ELQNMKVMKCG------------------------CA Lottia_gigantea_Nodal NSGCQLHDFEVDF-NSIGWGQ--WIIHP-KKFNARFCYGECASPID--VKYK---PTNHAMLQTLM--RSKR--K-N--S------A-PPACCVPT--KLNPLSMLY-YEF---DE---IV----VR-HHEEMIASECG------------------------CR Lottia_gigantea_Tgf1 EISCCREPVLFNF-EEAGLG---WIIAP-TGFYTSECAGSCHAHNG----------VRTSSG------------------------MTIEHSCRPN--NRKPLSVLY-ITKS--LN---IR----LG-LLPGIVVMDCS------------------------CQ Lottia_gigantea_Tgf2 TGQCCKLPSFVNF-SDLGLDD--RIVTP-NGYMTGSCIGRCPRTRH-----N---GRRNNRDQTQI--------PTERSR------S-RRSRCKPA--ETSSLTVLL-FNEN--HD---LM----QA-ELSGLVVNSCT-------------------------- Lottia_gigantea_Tgf3 ESRCCRNVVKIKA-QDIFP----QIIAP-DEFELTFCSGSCDDPMI--SPVN-----NYTRMIQSFRWRTGDELLRN---------A-IHFCCAPI--AFRAQSILL-YKA---GN---II----KY-DIPDLIPTACG------------------------CI Lymnaea_stagnalis_Nodal KENCQLHNFEVDF-NTIGWGQ--WIIHP-KKFNSRFCFGVCPSPID--VKYK---PTNHAMLQALM--RMKK--P-N--I------A-PVPCCVPS--KLNALSMMY-FEY---NE---LV----VR-HHEDMIAEECG------------------------CR Mnemiopsis_leidyi_Myostatin QKKCCRYHYFVKF-ADLGMD---WILAP-DGYDAYYCSGDCPFMYL-AEQKS---SLYYTFVIARA--NYNN--P-M--A------S-PRPCCTPA--SLSDLSIMF-SSGK--VDSTGQPLDVEIH-NLEDMVVDECG------------------------CS 'Mnemiopsis leidyi Nodal-related' SPHCRVRNLMVNF-NKIGLN---SVMAP-LEFNAHICSGQCHLDHE--E-TP---MTNHAFIQNML--YLSG--TGE--E------V-QGASCVSD--KMKPLSVLI-AAG---RD---FQ----LT-VYEDMVVDSCS------------------------CR Mnemiopsis_leidyi_Tgf1a NYHCRRQDLWINF-DEIGWD---FVITP-KDVNIGDCGGQCLDADS---------NIPHAVVKQLL--QKMH--PAR---------NAGILCCQGA--NYKEISALY-FKSK--HE---IV----IG-DMPKIIVKECR------------------------CR Mnemiopsis_leidyi_Tgf1b AFPRQKVKFDLNL-VDIGWDS--WMLIP-KMVDIGICQGTCNDMTA---------LILHAMAKHKI--SQVM--PNE--R------I-GQICCQEA--SYREIVALY--QVD--GS---LV----KS-ILPQFVVSSCK------------------------CR Mnemiopsis_leidyi_Tgf2 QHRCTMMEFYVNF-TKLGWGS--KIIHP-QIEKINQCAGQCPYPMS--HAID---HTTNALFRGAW--SKQF--P-G--S------V-ARPCCVPA--EYKPATLML-MQG---PV---TI----LK-IFDDLIITKCK------------------------CL Mnemiopsis_leidyi_Tgf3 EGKCGVRLLYLQF-EKDMSIP--SIRAP-QGVYVNYCSGSCPYLWK---TEN---PPLHTLILGQYAEQIRE-------S------R-YEPCCLPA--TYEAAEAIT-VENQ-------II-------KFEDLRVTSCK------------------------CV Mnemiopsis_leidyi_Tgf4 GEKCKLEPLYINF-RDLGWES--WVIAP-PGLEVGSCSGYCMREDI---------SSNYNLLINNI-----SRDPELYRLYGLAGIR-TERTCVPT--SFLPTVLMF-IGKD--QD---IV----VQ-LVDDILVGGCG------------------------CV Mnemiopsis_leidyi_TgfbA PRQCCKKDHWITF-KEVGLDH--IILEP-QAYNAGLCLGVCNEMWL--E------QFYHSHIMSLS--DNVQ----------------ARNCCAPA--SVDSLRIIY-YDEE--NDTHKFE-------TLPNMQVTECG------------------------CK Mus_musculus_Bmp10 GNYCKKTPLYIDF-KEIGWDS--WIIAP-PGYEAYECRGVCNYPLA--EHLT---PTKHAIIQALV--HLKN--S-Q--K------A-SKACCVPT--KLDPISILY-LDK---GV---VT----YKFKYEGMAVSECG------------------------CR Mus_musculus_Bmp2 KSSCKRHPLYVDF-SDVGWND--WIVAP-PGYHAFYCHGECPFPLA--DHLN---STNHAIVQTLV--NSVN----S--K------I-PKACCVPT--ELSAISMLY-LDEN--EK---VV----LK-NYQDMVVEGCG------------------------CR Mus_musculus_Bmp3 PRNCARRYLKVDF-ADIGWSE--WIISP-KSFDAFYCSGACQFPMP--KSLK---PSNHATIQSIV--RAVGV-V-S--G------I-PEPCCVPE--KMSSLSILF-FDEN--KN---VV----LK-VYPNMTVDSCA------------------------CR Mus_musculus_Bmp4 NKNCRRHSLYVDF-SDVGWND--WIVAP-PGYQAFYCHGDCPFPLA--DHLN---STNHAIVQTLV--NSVN----S--S------I-PKACCVPT--ELSAISMLY-LDEY--DK---VV----LK-NYQEMVVEGCG------------------------CR Mus_musculus_Bmp5 KQACKKHELYVSF-RDLGWQD--WIIAP-EGYAAFYCDGECSFPLN--AHMN---ATNHAIVQTLV--HLMF--P-D--H------V-PKPCCAPT--KLNAISVLY-FDDS--SN---VI----LK-KYRNMVVRSCG------------------------CH Mus_musculus_Bmp6 KTACKKHELYVSF-QDLGWQD--WIIAP-KGYAANYCDGECSFPLN--AHMN---ATNHAIVQTLV--HLMN--P-E--Y------V-PKPCCAPT--KLNAISVLY-FDDN--SN---VI----LK-KYRNMVVRACG------------------------CH Mus_musculus_Bmp7 RQACKKHELYVSF-RDLGWQD--WIIAP-EGYAAYYCEGECAFPLN--SYMN---ATNHAIVQTLV--HFIN--P-D--T------V-PKPCCAPT--QLNAISVLY-FDDS--SN---VI----LK-KYRNMVVRACG------------------------CH Mus_musculus_Gdf1 VGTCRTRRLHVSF-REVGWHR--WVIAP-RGFLANFCQGTCALPET-LRGPGGPPALNHAVLRALM--HAAA--PTP--G------A-GSPCCVPE--RLSPISVLF-FDNS--DN---VV----LR-HYEDMVVDECG------------------------CR Mus_musculus_Gdf11 ESRCCRYPLTVDF-EAFGW-D--WIIAP-KRYKANYCSGQCEYMFM-----Q---KYPHTHLVQQA-------NP-R--G------S-AGPCCTPT--KMSPINMLY-FNDK--QQ---II----YG-KIPGMVVDRCG------------------------CS Mus_musculus_Gdf3 RNFCHRHQLFINF-QDLGWHK--WVIAP-KGFMANYCHGECPFSMT--TYLN---SSNYAFMQALM--HMAD--P-K---------V-PKAVCVPT--KLSPISMLY-QDSD--KN---VI----LR-HYEDMVVDECG------------------------CG Mus_musculus_Gdf5 KARCSRKALHVNF-KDMGWDD--WIIAP-LEYEAFHCEGLCEFPLR--SHLE---PTNHAVIQTLM--NSMD--P-E--S------T-PPTCCVPT--RLSPISILF-IDSA--NN---VV----YK-QYEDMVVESCG------------------------CR Mus_musculus_Gdf6 RLRCSRKPLHVNF-KELGWDD--WIIAP-LEYEAYHCEGVCDFPLR--SHLE---PTNHAIIQTLM--NSMD--P-G--S------T-PPSCCVPT--KLTPISILY-IDAG--NN---VV----YK-QYEDMVVESCG------------------------CR Mus_musculus_Gdf7 RSRCSRKSLHVDF-KELGWDD--WIIAP-LDYEAYHCEGVCDFPLR--SHLE---PTNHAIIQTLL--NSMA--P-D--A------A-PASCCVPA--RLSPISILY-IDAA--NN---VV----YK-QYEDMVVEACG------------------------CR Mus_musculus_Gdf8 ESRCCRYPLTVDF-EAFGW-D--WIIAP-KRYKANYCSGECEFVFL-----Q---KYPHTHLVHQA-------NP-R--G------S-AGPCCTPT--KMSPINMLY-FNGK--EQ---II----YG-KIPAMVVDRCG------------------------CS Mus_musculus_InhibinbA VNICCKKQFFVSF-KDIGWND--WIIAP-SGYHANYCEGECPSHIAGTSGSS---LSFHSTVINHY--RMRGHSP-F--A------N-LKSCCVPT--KLRPMSMLY-YDDG--QN---II----KK-DIQNMIVEECG------------------------CS Mus_musculus_InhibinbB TSLCCRQQFFIDF-RLIGWND--WIIAP-TGYYGNYCEGSCPAYLAGVPGSA---SSFHTAVVNQY--RMRGLNP----G------P-VNSCCIPT--KLSSMSMLY-FDDE--YN---IV----KR-DVPNMIVEECG------------------------CA Mus_musculus_Lefty1 GTRCCRQEMYLDL-QGMKWAEN-WILEP-PGFLTYECVGSCLQLPE--------SLTSRWPFL-------------------------GPRQCVAS--EMTSLPMIV-SVKE--GGRTRPQ----VV-SLPNMRVQTCS------------------------CA Mus_musculus_Nodal SQLCRRVKFQVDF-NLIGWGS--WIIYP-KQYNAYRCEGECPNPVG--EEFH---PTNHAYIQSLL--KRYQ--P-H--R------V-PSTCCAPV--KTKPLSMLY-VDN---GR---VL----LE-HHKDMIVEECG------------------------CL Mus_musculus_Tgfb1 EKNCCVRQLYIDFRKDLGWK---WIHEP-KGYHANFCLGPCPYIWS-----L---DTQYSKVLALY--NQHN--P-G--A------S-ASPCCVPQ--ALEPLPIVY-YVGR--KP----K----VE-QLSNMIVRSCK------------------------CS Mus_musculus_Tgfb2 QDNCCLRPLYIDFKRDLGWK---WIHEP-KGYNANFCAGACPYLWS-----S---DTQHTKVLSLY--NTIN--P-E--A------S-ASPCCVSQ--DLEPLTILY-YIGN--TP----K----IE-QLSNMIVKSCK------------------------CS Mus_musculus_Tgfb3 EENCCVRPLYIDFRQDLGWK---WVHEP-KGYYANFCSGPCPYLRS-----A---DTTHSTVLGLY--NTLN--P-E--A------S-ASPCCVPQ--DLEPLTILY-YVGR--TP----K----VE-QLSNMVVKSCK------------------------CS Nematostella_vectensis_Activin MRECCRQEFYVSF-EEMGWDN--WILVP-RGFNANYCTGSCYGHIL--P------VYHHTEVIQKVA-LLRKQR-----E--------LSPCCAPT--KMFDLSLLY-YDKD--EN---LF----QE-NVSNMVVEECG------------------------CS 'Nematostella vectensis Bmp2/4' PQYCQRHPLYVDF-TDVGWND--WIVAP-PGYHAFYCTGVCPYPIA--KHLN---ATNHAIVQTIM--NTVD----S--N------V-PNACCIPT--TLNPISILS-LNEF--DK---VV----LK-NYKDMVIEGCG------------------------CR 'Nematostella vectensis Bmp5-8' KKVCQRQALHVSF-RKLRWQD--WVIAP-EGYSAFYCSGECSFPLN--ANMN---ATNHAIVQTLV--HLMN--P-K--T------V-PKPCCAPT--ELSPISVLY-FDQD--NN---VV----LK-KYNKMVVKACG------------------------CH 'Nematostella vectensis Gdf5-like' KRKCRRKRMYVDF-RLLGWSD--WIIAP-QGYDAYLCEGECKYPID--NYLR---PTNHATVQTIV--NSLD--P-S--I------A-PKACCTPN--ELSPISILY-TEDGS-NN---VV----YK-NYKDMVVERCG------------------------CS Nematostella_vectensis_Gdf8 ERRCCRYELTVDF-EKFSWN---WIIAP-KRFRAYYCTGECQEIML-----P---MYPHAHMVKKS-------------T------G-KRPCCSPT--KMSSISMIY-FDFN--QQ---IM----FE-EVPAMVAETCG------------------------CT 'Oscarella carmela Activin-like' QERCCRMPLTITL-EDLGWSS--WVFAP-SEFEAFFCKGSCPKHYK-----P---ASRHASITSLL--AGKY----KRYR------K-GNRCCSPT--SLSSVTLIH-FSNS--GE---IT----ST-EFENLSVENCG------------------------CS Oscarella_carmela_Tgf1 NGVCSRRSYYVDF-QKIGWS---HIVRP-LGYFAYYCGGECPKFFT--SAMN---MTNHASLQALM--HYLYGGP----K------Y-PPVSCVPV--SYEPLVVAF-PDRN--GH---FK----IR-TYKNMVAKHCG------------------------CH Oscarella_carmela_Tgf2 NKVCRRKKLNFSF-VEMAWGN--WIVAP-LVFDGGVCRGECRAPLT--HATN---NTNHAIMQSLL--ARGS----K--K------M-PKVPCAPI--SFKPLKILF-YDSD--NS---LK----YV-FYKQSSVAVCG------------------------CR Oscarella_carmela_Tgf3 EDVCKRHPLLVNF-TDVGWF---HIIHP-PVVDIGVCSGVCGSLEK---VYH---NSVHAEVLAIL--RARTKGKESNRK------QKPGPSCTPM--TFKAIKVKR-RLGN--TT---------FDGVIPRLVVESCM------------------------CS Oscarella_carmela_Tgfb1 LDNCCIREFYIDFKKDLGWT---WIIQP-KGFYANECSGECPMYWA-----E---DTNHTQVINEY--RTLN--PEA---------S-VAPCCTPK--TLNDLEMLH-FPGG--GPPGPPI----TS-TLTDMLVTSCI------------------------CA Oscarella_carmela_Tgfb2 SGCCGLNELYVDFHRDLGFH---WIIQP-SGYWVNECTGECPDFLE-----S---DVEHGRILNLF--YSVN--PTA---------S-ASPCCVAK--SYESIDVLY-VTEK--NE---IK----VK-EMSDMIASACS------------------------CR 'Saccoglossus kowalevskii Activin-like' ISICCRKSFYVSF-EDIHWND--WIIEP-SGFYANHCNGSCEGNTL--P------RYQHTTMMQRVS-RLYSRHNS-QRPS-----D-LTPCCTPT--AMSGITLLY-YNST--GY---II----KK-NLPNMSVESCG------------------------CS Saccoglossus_kowalevskii_Admp KTPCSKQKLYVDF-EEIGWSG--WIISP-RGYNAYHCKGECPFPLG--QTSK---PTNHATVQSIV--NALKL-G-D--E------V-AMPCCVPD--KLFSISLLY-FDED--DN---VV----LK-QYDDMVAASCG------------------------CH 'Saccoglossus kowalevskii Bmp10-like' KNACQRQPMYVHF-KDIGWDE--WIIAP-KGYQAYQCNGKCTFPLT--DHWS---PTKHAIVQTLV--HSAK--P-S--K------V-SRVSCVPT--KLDPISILY-YDDA--GV---VT----YKYKYDGMVVAECG------------------------CR 'Saccoglossus kowalevskii Bmp2/4' KLNCKRHELYVDF-NDVGWND--WIVAP-PGYHAFYCHGECPFPIA--EHLN---STNHAIVQTLV--NSVS--P-D--S------V-PKACCVPT--DLSPISMLY-LDEF--DK---VV----LK-NYQDMVVEGCG------------------------CR 'Saccoglossus kowalevskii Bmp3-like' WKLCGRHVMRVDF-QLIGWNA--YVISP-KSFDAFYCSGECPFPMT--KELN---PSNHAAVQSIV--HALDA-V-K--G------V-PPPCCVPD--KLSPLSILY-FDES--RN---VV----LK-VYPNMVVDTCA------------------------CR 'Saccoglossus kowalevskii Bmp5-8' DRSCKKRSLVVSF-RELGWQD--WIIAP-DGYSAFYCNGECSFPLN--AHMN---ATNHAIVQTLV--HLMD--P-E--A------V-PKPCCAPT--KLNAISVLY-FDDS--SN---VI----LK-KYRNMIVKSCG------------------------CH 'Saccoglossus kowalevskii Gdf8/11-like' EERCCRYPLVVDF-VELTW-D--WIIAP-KTYSAYYCAGECPNVYN-----L---QNAHSYFVERA-------NP-R--G------H-AGRCCTGS--EMSPISMIY-FIDE--KS---IM----FG-VVPDMVTIKCE------------------------CS Saccoglossus_kowalevskii_Lefty SETCCRRPKYISF-RNMEWTNR-WIIEP-RGYEAYECVGPCHI------------RHSSQAT--------------------------DLINCGVS--KSSPLPMMY-LIQK--GDITQVE----VS-EIPNMVVEECE------------------------CL Saccoglossus_kowalevskii_NodalA HP-CERVELIVDF-DKIGWGS--WIIFP-KKFDAYQCVGSCPGPVD--GEHN---PNNHAIIQNMV--HTSN--P-D--R------V-PLPCCVPT--KLSSLSMLY-YER---GN---IV----VK-EHEGMVIQECG------------------------CR Saccoglossus_kowalevskii_Tgfb2 ETNCCLRQLYIDFKKDLGWT---WIHAP-QGYNANYCGGACPYLWS-----Q---NTQHTTILSLY--QSLN--P-D--A------S-AVPCCVPK--TLESLTILY-YESR--KP----K----IT-QLTNMVLTSCK------------------------CS 'Saccoglossus kowalevskii Univin-like' ADICKRHPLYVNF-REVGWHD--WIIAP-AGYEAFYCHGDCPFPLN--ENLN---GTNHAIIQTLV--NTIE--P-N--A------VKSKACCAPT--KLSSISMLY-FDNN--DN---VV----LR-QYENMVVEACG------------------------CL 'Strongylocentrotus purpuratus Bmp2/4' KANCRRHELYVDF-SDVHWND--WIVAP-AGYQAYYCRGECPFPLA--EHLN---TTNHAIVQTLV--NSVN--P-A--L------V-PKACCVPT--ELSAISMLY-LDEY--EK---VV----LK-NYQDMVVEGCG------------------------CG Strongylocentrotus_purpuratus_Bmp3 TNVCDRHSMNVDF-QAIGWDD--YVIAP-ATFQAFYCAGQCAFPIQ--KELH---PSNHALIQSIM--HLLG--VQT--G------V-PTPCCVPD--KMEPLVLLY-IEQD--ST---VT----LK-KYSDMVVESCG------------------------CH Strongylocentrotus_purpuratus_Lefty EHRCCRRRKYVDF-RDLSWTSR-WIIEP-AGFEAFDCYGPCHNLRS---------RHIRDIFRLPFYGGSPSGLPSR---------SGGHRTCGVS--RSSALPMMY-LSATE-SGAVELK----VE-EIPNMIVEDCS------------------------CL Strongylocentrotus_purpuratus_Nodal GP-CRRIDMDVDF-GRIGWDE--WIIYP-KQFNAYRCVGTCKGPLD--SRDN---PSNHAVMQDLV--RLHQ--PER--R------T-PEPCCVPT--ILRPLSMLY-FEE---GA---VL----VR-HHENMIVEECG------------------------CR Strongylocentrotus_purpuratus_Univin TNLCQRHRLFVSF-RDVGWEN--WIIAP-MGYQAYYCDGECPFPLG--ERLN---GTNHAIIQTLV--NSID--N-R--A------V-PKVCCAPT--KLSGISMLY-FDNN--EN---VV----LR-QYEDMVVEACG------------------------CR Tribolium_castaneum_Activin GNQCCKQRFYVSF-KQLGWDD--WVIAP-QGYHANYCRGDCGLHRT--PDTY---VTYHTHVIEEV--RKTHHLS----G--------MQPCCAPL--KFSSMSLIY-YGPD--MT---II----KR-DLPKMVVDECG------------------------CP Tribolium_castaneum_Gdf8 EPLCCRYPLTVDF-EEFGW-D--FIIAP-KRYDAHYCSGECPYVTL-----Q---KYPHTHLMKMA-------SP----N------S-AQPCCAPR--KMSAISMLY-FDNQ--LN---VV----YG-SLPGMVVDRCG------------------------CS Xenopus_laevis_Admp QLPCQRHPLYVDF-EEIGWSG--WIISP-RGYNAYHCKGSCPFPLG--QNMR---PTNHATVQSII--NALKL-T-K--G------V-SSPCCVPD--KLFSINLLY-FDDD--EN---VV----LK-QYDDMVAGSCG------------------------CH Xenopus_laevis_Bmp2 KSSCRRHPLYVDF-SDVGWND--WIVAP-PGYHAFYCHGECPFPLA--DHLN---STNHAIVQTLV--NSVN----T--N------I-PKACCVPT--ELSAISMLY-LDEN--EK---VV----LK-NYQDMVVEGCG------------------------CR Xenopus_laevis_Bmp3 PRNCARRYLKVDF-ADIGWSE--WIISP-KSFDAYYCSGACQFPMP--KSLK---PSNHATIQSIV--RAVGV-V-P--G------I-PEPCCVPE--KMSSLSILF-LDEN--KN---VV----LK-VYPNMTVESCA------------------------CR Xenopus_laevis_Bmp4 NKHCRRHSLYVDF-SDVGWND--WIVAP-PGYQAFYCHGDCPFPLA--DHLN---STNHAIVQTLV--NSVN----A--S------I-PKACCVPT--ELSAISMLY-LDEY--DK---VV----LK-NYQEMVVEGCG------------------------CR Xenopus_laevis_Bmp6 KTACRKHELYVSF-QDLGWQD--WIIAP-KGYSANYCGGECSFPLN--AHMN---ATNHAIVQTLV--HLMN--P-E--Y------V-PKPCCAPT--KLNAVSVLY-FDDN--SN---VI----LK-KYRNMVVRACG------------------------CH Xenopus_laevis_Bmp7 KQACKKHELFVSF-RDLGWQD--WIIAP-EGYAAYYCEGECAFPLN--SFMN---ATNHAIVQTLV--HFIN--P-E--T------V-PKPCCAPT--QLNGISVLY-FDDS--AN---VI----LK-KYKNMVVQACG------------------------CH Xenopus_laevis_Derriere SNICKKRRLYIDF-KDVGWQN--WVIAP-RGYMANYCHGECPYPLT--EMLR---GTNHAVLQTLV--HSVE--P-E--N------T-PLPCCAPT--KLSPISMLY-YDNN--DN---VV----LR-HYEDMVVDECG------------------------CK Xenopus_laevis_Gdf6 RLRCSKKPLHVNF-KELGWDD--WIIAP-LEYEAHHCEGVCDFPLR--SHLE---PTNHAIIQTLM--NSMN--P-G--S------T-PPSCCVPT--KLTPISILY-IDAG--NN---VV----YK-QYEDMVVESCG------------------------CR Xenopus_laevis_Gdf7 KTRCSKKPLLVNF-KELGWDD--WIIAP-LDYEAYHCEGVCDFPLR--SHLE---PTNHAIIQTLM--NSMD--P-E--S------T-PPSCCVPS--KLSPISILY-IDSG--NN---VV----YK-QYEDMVVESCS------------------------CR Xenopus_laevis_InhibinbB TNLCCRQQFYIDF-RLIGWND--WIIAP-AGYYGNYCEGSCPAYLAGVPGSA---SSFHTAVVNQY--RMRGLNP----G------T-VNSCCIPT--KLSTMSMLY-FDDE--YN---IV----KR-DVPNMIVDECG------------------------CA Xenopus_laevis_InhibinbC SNLCCRKDYYVDF-KDIGWND--WIIKP-EGYQINYCMGLCPMHIAGAPGMA---ASFHTTVLNLI--KANNIQT-----------A-VNSCCVPT--KRRPLSMLY-FDRN--NN---VL----KT-DIADMIVEACG------------------------CS Xenopus_laevis_Lefty DNICCREEYFINF-RELTWTQY-WIIEP-AGYNAFRCAGSCKQPKY---------PLSH-HY--------------------------GERMCAVV--ESAPLPVMY-LVKK--GDYTEIE----VA-EFPNMIVEKCG------------------------CT Xenopus_laevis_Ndr1 KPLCRRVDMIVDF-EDIGWSS--WIVYP-KKYNAYRCEGACPIPLN--ETFK---PTNHAYMKSVV--KLYQ--P-E--R------V-ECPLCVPV--KMSPLSMLY-YEG---DE---VV----LR-HHQEMIVEECG------------------------CS Xenopus_laevis_Ndr2A KTLCRRVDMIVDF-EKIEWGD--RIVYP-KRFNAYRCEGACPIPLN--ETFK---PTNHAYIKSLV--KLYD--Q-E--K------V-ECSSCVPV--KMSPLSMLL-YED---GE---VV----LK-HHEDMIVDECG------------------------CN Xenopus_laevis_Tgfb1 GPNCCVKPLYINFRKDLGWK---WIHEP-KGYEANYCLGNCPYIWS-----M---DTQYSKVLSLY--NQNN--P-G--A------S-ISPCCVPD--VLEPLPIIY-YVGR--TA----K----VE-QLSNMVVRSCN------------------------CS Xenopus_laevis_Tgfb2 QDNCCLRPLYIDFKKDLGWK---WIHEP-KGYNANFCAGACPYLWS-----S---DTQHSRVLSLY--NTIN--P-E--A------S-ASPCCVSQ--DLDSLTILY-YIGN--KP----K----IE-QLSNMIVKSCK------------------------CS 'Xenopus laevis Vg-1' SNICKKRRLYVEF-KDVGWQN--WVIAP-QGYMANYCYGECPYPLT--EILN---GSNHAILQTLV--HSIE--P-E--D------I-PLPCCVPT--KMSPISMLF-YDNN--DN---VV----LR-HYENMAVDECG------------------------CR 'Xenopus tropicalis Bmp10-like' GNYCKKTPLYIDF-GEIGWNS--WIIAP-QGYEAYECRGVCSYPLT--EHVT---PTKHAIVQTLV--HMKN--A-Q--K------A-SKACCVAT--KLDPISILY-LDA---GV---VT----YKFKYEGMVVAECG------------------------CR 'Xenopus tropicalis Bmp5-like' KQACKKHELYVSF-RDLGWED--WIIAP-EGYAAFYCDGECSFPLN--AHMN---ATNHAIVQTLV--HLMF--P-D--H------V-PKPCCAPT--KLNAISVLY-FDDS--SN---VI----LK-KYRNMVVRSCG------------------------CH 'Xenopus tropicalis Gdf11-like' ESRCCRYPLTVDF-EAFGW-D--WIIAP-KRYKANYCSGQCEYMFM-----Q---KYPHTHLVQQA-------NP-R--G------S-AGPCCTPT--KMSPINMLY-FNDK--QQ---II----YG-KIPGMVVDRCG------------------------CS Xenopus_tropicalis_Gdf5 KARCSKKPLHVNF-KDMGWDD--WIIAP-LEYEAYHCEGLCEFPLR--SHLE---PTNHAVIQTLM--NSMD--P-E--T------T-PPTCCVPT--RLSPISILY-TDSA--NN---VV----YK-QYEDMVVESCG------------------------CR Xenopus_tropicalis_Gdf6 RLRCSKKPLHVNF-KELGWDD--WIIAP-LEYEAYHCEGVCDFPLR--SHLE---PTNHAIIQTLM--NSMD--P-G--S------T-PPSCCVPT--KLTPISILY-IDAG--NN---VV----YK-QYEDMVVESCG------------------------CR 'Xenopus tropicalis Gdf8-like' ESRCCRYPLTVDF-EAFGW-D--WIIAP-KRYKANYCSGECGIVFL-----Q---KYPHTHLVQQA-------NP-R--G------S-AGPCCTPT--KMSPINMLY-FNEN--EQ---II----YG-KIPAMVVDRCG------------------------CS ; END;