#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 19, 2025; 5:29 GMT TreeBASE (cc) 1994-2008 Study reference: Watanabe H., Schmidt H.A., Kuhn A., Höger S.K., Kocagöz Y., Laumann-lipp N., Özbek S., & Holstein T.W. 2014. Nodal signalling determines biradial asymmetry in Hydra. Nature, . TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S16190] BEGIN TAXA; TITLE Untitled_Taxa_Block; DIMENSIONS NTAX=76; TAXLABELS 'Acropora digitifera Smad1/5/8' 'Acropora digitifera Smad2/3' Acropora_digitifera_Smad4 'Acropora digitifera Smad6/7' 'Acropora millepora Smad1/5/8a' 'Acropora millepora Smad1/5/8b' 'Acropora millepora Smad2/3' Acropora_millepora_Smad4 'Amphimedon queenslandica R-Smada' 'Amphimedon queenslandica R-Smadb' 'Amphimedon queenslandica Smad1/5a' 'Amphimedon queenslandica Smad1/5b' 'Amphimedon queenslandica Smad2/3' Amphimedon_queenslandica_Smad4a Amphimedon_queenslandica_Smad4b 'Branchiostoma floridae Smad2/3' Branchiostoma_floridae_Smad4 'Branchiostoma floridae Smad6/7' 'Ciona intestinalis Smad1/5' 'Ciona intestinalis Smad2/3a' 'Ciona intestinalis Smad2/3b' Ciona_intestinalis_Smad4 'Ciona intestinalis Smad6/7' 'Cladonema pacificum Smad1/5/8a' 'Cladonema pacificum Smad1/5/8b' 'Cladonema pacificum Smad2/3a' 'Cladonema pacificum Smad2/3b' Cladonema_pacificum_Smad4 Danio_rerio_Smad1 Danio_rerio_Smad2 Danio_rerio_Smad3 Danio_rerio_Smad4 Danio_rerio_Smad5 Danio_rerio_Smad9 Drosophila_melanogaster_Smad1 'Drosophila melanogaster Smad2/3' Drosophila_melanogaster_Smad4 'Drosophila melanogaster Smad6/7' 'Hydra magnipapillata Smad1/5' 'Hydra magnipapillata Smad2/3' Hydra_magnipapillata_Smad4 'Lottia gigantea Smad1/5' 'Lottia gigantea Smad2/3' Lottia_gigantea_Smad4 Lottia_gigantea_Smad6 'Mnemiopsis leidyi R-Smada' 'Mnemiopsis leidyi R-Smadb' 'Mnemiopsis leidyi Smad2/3-like' Mnemiopsis_leidyi_Smad4 'Mnemiopsis leidyi Smad6/7' Mus_musculus_Smad1 Mus_musculus_Smad2 Mus_musculus_Smad3 Mus_musculus_Smad4 Mus_musculus_Smad5 Mus_musculus_Smad6 Mus_musculus_Smad8 Mus_musculus_Smad9 'Nematostella vectensis Smad1/5' 'Nematostella vectensis Smad2/3' Nematostella_vectensis_Smad4 'Nematostella vectensis Smad6/7' 'Oscarella carmela Smad1/5/8' Oscarella_carmela_Smad4 'Saccoglossus kowalevskii Smad1/5' 'Saccoglossus kowalevskii Smad2/3' Saccoglossus_kowalevskii_Smad4 Saccoglossus_kowalevskii_Smad6 Tribolium_castaneum_Smad1 Tribolium_castaneum_Smad4 Tribolium_castaneum_Smad5 'Tribolium castaneum Smad6/7' 'Trichoplax adhaerens Smad1/5' 'Trichoplax adhaerens Smad2/3' Trichoplax_adhaerens_Smad4 'Trichoplax adhaerens Smad6/7' ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M23500] TITLE Smad_gene_family_alignment; LINK TAXA = Untitled_Taxa_Block; DIMENSIONS NCHAR=115; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 ] [ . . . . . . . . . . . ] 'Acropora digitifera Smad1/5/8' SERFCLGLLSNVNRNSTIEST---------RRHIGKG-VHLYYVG--GEVYAECLSDSAIFVQSRNCN------HSHGFHP-TTVCKIPSG--CTLKIFNNQEFAQLLSQSVNYG 'Acropora digitifera Smad2/3' SDRFCLGLLSNINRNPQIEMT---------RKHIGKG-VRLYYIG--GEVFAECLSDSSIFVQSPNCN------QRYGWHP-ATVCKIPPG--CNLKIFNNQEFAQLLSQSVNQG Acropora_digitifera_Smad4 -SRFCLGQLSNVHRTDASEKA---------RLHIGKGVQLDLRGE--GDVWVRCLSEHSVFVQSYYLD------REAGRCPGDAVHKIYPS--AYIKVFDLRQCYHQIKQQAHAA 'Acropora digitifera Smad6/7' --GFCLADLNRSSDVSEGTKR--------VRSQIGYG-LQLTRER--EEIWIYNRSNFSLFANGPTLTFSDVNIPGGKLRHNIVVHKVPPG--CSLKVFDYKLT--PQVCRAIDS 'Acropora millepora Smad1/5/8a' SERFCLGLLSNVNRNSTIEST---------RRHIGKG-VHLYYVG--GEVYAECLSDSAIFVQSRNCN------HSHGFHP-TTVCKIPSG--CTLKIFNNQEFAQLLSQSVNYD 'Acropora millepora Smad1/5/8b' SERFCLGLLSNVNRNSTIEST---------RRHIGKG-VHLYYVG--GEVYAECLSDSAIFVQSRNCN------HSHGFHP-TTVCKIPSG--CTLKIFNNQEFAQLLSQSVNYG 'Acropora millepora Smad2/3' SDRFCLGLLSNINRNPQIEMT---------RKHIGKG-VRLYYIG--GEVFAECLSDSSIFVQSPNCN------QRYGWHP-ATVCKIPPG--CNLKIFNNQEFAQLLSQSVNQG Acropora_millepora_Smad4 -SRFCLGQLSNVHRTDASEKA---------RLHIGKGVQLDLRGE--GDVWVRCLSEHSVFVQSYYLD------REAGRCPGDAVHKIYPS--AYIKVFDLRQCYHQIKQQAHAA 'Amphimedon queenslandica R-Smada' SSRYCLGRITNVNRNEAINKA---------RKFIGNG-IIIRFRN--HELVVENHGSAAVFVNSKMTN------FEHCLPR-STVIKVPNN--YYLKIFDTSLFSYVLSKTAKDG 'Amphimedon queenslandica R-Smadb' SSRYCLGRITNVNRNETINKA---------RKFIGNG-IIIRYRN--HELVVENHGSAAVFVNSKMTN------FEHCLPR-STVIKVPNN--YYLKIFDTNLFSYVLSKTAKDG 'Amphimedon queenslandica Smad1/5a' GERFCLGQFSSIRRSGLIENT---------RRHIGKG-VHLVYVN--GEVIADCLSENAIFVHSRNNN------FSNGFHP-TTVCKIPPG--CSLRIFNNQDFASTLAESVTEG 'Amphimedon queenslandica Smad1/5b' GDRFCLGLLSSVHRNSTIENT---------RRHIGKG-VHLVYVN--GEVFAECLSENSIFVQSRNCN------SSHGFHL-TTVCKIPPG--CSLKIFNNQDFASMLAQSVHQG 'Amphimedon queenslandica Smad2/3' TDRFCLGKMCNVNRDNITIQA---------RKHIGQG-IKLMYIG--GEVHLECLGKNAVFVQAPNAN------LRNRWES-ATVVKVPQG--CLLDLFNSQDFAKRLADAVHLG Amphimedon_queenslandica_Smad4a -DRFCLGRLSNVHRTEPSKRV---------ISHIEKGIVIEEKNE--TEVWIRCVSRHSVFVQSNYLD------YQAGQAQGDAVHKIYPN--AYIKVFDLSYY----------- Amphimedon_queenslandica_Smad4b -DRFCLGRLSNVHRTEASERA---------RLHIGKGIIIEEKNE--TEVWIRCVSEHSVFVQSYYLD------YQAGRALGDAVHKIYPK--AYIKVFDLRHCYEEMQKQAHEA 'Branchiostoma floridae Smad2/3' SERFCLGLLSNVNRNHVIEQT---------RRHIGKG-VRLYYIG--GEVFAECLSESSVFVQSPNCN------QRYGWHP-ATVCKIPPG--CNLKIFNNQEFAQLLSQSVSQG Branchiostoma_floridae_Smad4 -DRFCLGQLSNVHRTEASERA---------RLHIGKGVQLDLRGE--GDVWVRCLSDHAVFVQSYYLD------REAGRAPGDAVHKIYPS--AYIKVFDLRQCHRQMQQQAATA 'Branchiostoma floridae Smad6/7' --GFCLGLLSSS-ESHSENVV-------RTRKKIGYG-LTLSKEP--DGVWAYNRSSHAIFVNSPTLD------IPNSRT--LIVRKIPPG--FSIKIFDYGRS-EMLQRTSNPD 'Ciona intestinalis Smad1/5' SNRFCLGQLSNVNRNSTIENT---------RRHISKG-VHLYYVG--GEVYAECLSDSSIFVQSRNCN------YHHGFHP-TTVCKIPPS--CSLKIFNNQEFAALLSQSVNHG 'Ciona intestinalis Smad2/3a' SERFCLGLLSNINRNQQIELT---------RRHVGKG-VRLYYIG--GEVFAECLGESSIFVQSPNCN------NRYGWHP-ATVVKIPPG--CNLKIFNNQEFAALLSQLVNQG 'Ciona intestinalis Smad2/3b' SERFCLGLLSNINRTQHVEIT---------RRHVGKG-VRLYYIA--GEVFAECLSDSAIFVQSPNCN------QRYGWHP-ATVVKIPPG--CHLKIFNNQEFAALLSQSVNQG Ciona_intestinalis_Smad4 -NRFCLGQLSNVHRTEASEKA---------RLHIGKGVQLVCHGE--GDVWVKCLSDHAVFVQSYYLD------REAGRSPGDAVHKIYPN--AYIKVFDLRQCHRQMQQQANTA 'Ciona intestinalis Smad6/7' --GFCLSAVS----SQTSRSA-------KVRRLIGHG-VTIGIDPTLQEASLYNRSDYPVFVNSPVLE------PIPSRS--QLVHKVLPG--ECCRIFSHEVAADLKRLHSHHV 'Cladonema pacificum Smad1/5/8a' SDRFCLGGMSNVNRNSTIENT---------RRHISKG-VHLYYVG--GEVFAECLSDSAIFVQSRNCN------YHHGFHP-TTVCKIPPQ--CTLKIFNNQEFAQLLSQSVNHG 'Cladonema pacificum Smad1/5/8b' SDRFCLGGMSNVNRNSTIENT---------RRHISKG-VHLYYVG--GEVFAECLSDSAIFVQSRNCN------YHHGFHP-TTVCKIPPQ--CTLKIFNNQEFAQLLSQSVNHG 'Cladonema pacificum Smad2/3a' LDRFCLGLLSNINRTEQVEEC---------RRAIAKG-VRLYYFG--GEVFAECLSVSSIFVQSANCN------RRYGWHP-ATVCKIPSG--CNLKIFNNQEFAKLLSERVPLG 'Cladonema pacificum Smad2/3b' VERFCLGLLSNINRTEQVEES---------RRHIGKG-VRLYYFG--GEVFAECLSKGSIFVQSANCN------RRYGWHP-ATVCKIPSG--CNLKIFNNQEFAGLLSESVNKG Cladonema_pacificum_Smad4 ----------------------------------GRGIQLDRRGE--GDVWVRCLSDQSVFVSSYYLD------RQAGRSPGDAVHKIYPQ--AYIKVFDLRMCFEQMKQQAQAA Danio_rerio_Smad1 RNRFCLGLLSNVNRNSTIENT---------RRHIGKG-VHLYYVG--GEVYAECLSDSSIFVQSRNCN------YHHGFHP-TTVCKIPSR--CSLKIFNNQEFAELLAQSVNHG Danio_rerio_Smad2 SERFCLGLLSNVNRNATVEMT---------RRHIGRG-VRLYYIG--GEVFAECLSDSAIFVQSPNCN------QRYGWHP-ATVCKIPPG--CNLKIFNNQEFAALLAQSVNQG Danio_rerio_Smad3 SERFCLGLLSNVNRNAAVELT---------RRHIGRG-VRLYYIG--GEVFAECLSDSAIFVQSPNCN------QRYGWHP-ATVCKIPPG--CNLKIFNNQEFAALLAQSVNQG Danio_rerio_Smad4 -DRFCLGQLSNVHRTEAIERA---------RLHIGKGVQLECKGE--GDVWVRCLSDHAVFVQSYYLD------REAGRAPGDAVHKIYPS--AYIKVFDLRQCHRQMQQQAATA Danio_rerio_Smad5 KNRFCLGLLSNVNRNSTIENT---------RRHIGKG-VHLYYVG--GEVYAECLSDTSIFVQSRNCN------YHHGFHP-TTVCKIPSG--CSLKIFNNQEFAQLLAQSVNHG Danio_rerio_Smad9 KNRFCLGLLSNVNRNSTIEHT---------RRHIGKG-VHLYYVG--GEVYAECLSDSSIFVQSRNCN------YQHGFHP-TTVCKIPSG--CSLKIFNNQLFAQLLSQSVNHG Drosophila_melanogaster_Smad1 SDRCCLGQLSNVNRNSTIENT---------RRHIGKG-VHLYYVT--GEVYAECLSDSAIFVQSRNCN------YHHGFHP-STVCKIPPG--CSLKIFNNQEFAQLLSQSVNNG 'Drosophila melanogaster Smad2/3' SERFCLGLLSNVNRNEVVEQT---------RRHIGKG-VRLYYIG--GEVFAECLSDSSIFVQSPNCN------QRYGWHP-ATVCKIPPG--CNLKIFNNQEFAALLSQSVSQG Drosophila_melanogaster_Smad4 -NRFCLGALSNVHRTEQSERA---------RLHIGKGVQLDLRGE--GDVWLRCLSDNSVFVQSYYLD------REAGRTPGDAVHKIYPA--ACIKVFDLRQCHQQMHSLATNA 'Drosophila melanogaster Smad6/7' --EVDSMCLRDLTPAGNQIHS----VVPKARHTVGLG-VTLSLEN--GDVWIYNRGNTTIFVDSPTLS------ENLDR-----VCKVMPG--YCLKAFETNRA-ELLSMRDHGH 'Hydra magnipapillata Smad1/5' SDRFCLGGMSNVNRNSTIENT---------RRHISKG-VHLYYVG--GEVFAECLSDSAVFVQSKNCN------YHHGFHP-STVCKIPPQ--CTLKIFNNQEFAQLLSQSVNHG 'Hydra magnipapillata Smad2/3' QDRFCLGLLSNINRTEQIELS---------RRHIGKG-VRLYYFG--GEVFAECLSNSSIFVQSSNCN------RRYGWHP-ATVCKIPPS--CNLKIFNNQEFAELLSQCVPRG Hydra_magnipapillata_Smad4 GYNLYRSDRNDVHRG-------------------GRGIKLDRRGE--GDVWVRCLSDQSVFVSSYFLD------RQAGRSPGDAVHKIYPQ--AYIKVFDLRMCYEQMKQQAQAA 'Lottia gigantea Smad1/5' ADRFCLGLLSNVNRNSTIENT---------RRHISKG-VHLYYVG--GEVFAECLSDSSIFVQSRNCN------YHHGFHP-TTVCKIPPG--CSLKIFNNQEFATLLSQSVNHG 'Lottia gigantea Smad2/3' SERFCLGLLSNVNRTQQVEMT---------RRYIGKG-VRLYYIG--GEVFAECLSENAVFVQSPNCN------QRYGWHP-ATVCKIPPG--CNLKIFNNQEFAALLAQSVNQG Lottia_gigantea_Smad4 IDRFCLGQLSNVHRTEASERA---------RLHIGKGVQLDYRGE--GDVWIRCVSDHSVFVQSYYLD------REAGRAPGDAVHKIYPS--AYIKVFDIRQCHRQMQQQAATA Lottia_gigantea_Smad6 --GMSLEILQN--KPNLESVK-------RTREKIGFG-IILSKEA--DGVWVYNRSSYPIFVNSPTLD------DPESRT--LIVRKVLPG--YSIKIYDFELA-KELELSRDPA 'Mnemiopsis leidyi R-Smada' QQRFCLGQLSNVSRNNTVEKT---------RKHIGRG-VKISFED--NKVYIECLGDSAVFVQSRNSN------KEYGFHP-STVVKIQSG--VKLKIFCHKLFHEILTQQLTEG 'Mnemiopsis leidyi R-Smadb' KDRYCIGLLSNVARNPMIEAT---------RKHINRG-VKLTKVN--GEVHAECLSDSAIFVQSRNCN------RERGFHP-STVCKLPPG--YKLRIFNYSDFYRLLQDNVHNG 'Mnemiopsis leidyi Smad2/3-like' NRRFCLGQLTNINRTPPVEKC---------RKQIGKG-IHLQYVQ--GEVHAVCLSDSSIFVQSQNCN------QRNGWHP-NTVCKIPTG--CHLNIFNNTEFANLLSQSVGHG Mnemiopsis_leidyi_Smad4 -NRFCLGQLSNVHRTEASEKA---------RLHVGKGVKLTLSGE--GDVWLECQSQHPVFVQSQYLD------KEAKRAPGDAVHKIFPG--THLKVFDLHDCYDTIKNKAQKA 'Mnemiopsis leidyi Smad6/7' --GLDLSKIANDDVSRDEVTA-------RVRKHIGSG-ILVSLEE--DGIWLYNRSEISIFVQSPTMS------TGDKSR--LQVHKVLPG--YALNSY--------HFAHHSTV Mus_musculus_Smad1 KNRFCLGLLSNVNRNSTIENT---------RRHIGKG-VHLYYVG--GEVYAECLSDSSIFVQSRNCN------YHHGFHP-TTVCKIPSG--CSLKIFNNQEFAQLLAQSVNHG Mus_musculus_Smad2 SERFCLGLLSNVNRNATVEMT---------RRHIGRG-VRLYYIG--GEVFAECLSDSAIFVQSPNCN------QRYGWHP-ATVCKIPPG--CNLKIFNNQEFAALLAQSVNQG Mus_musculus_Smad3 SERLCLGLLSNVNRNAAVELT---------RRHIGRG-VRLYYIG--GEVFAECLSDSAIFVQSPNCN------QRYGWHP-ATVCKIPPG--CNLKIFNNQEFAALLAQSVNQG Mus_musculus_Smad4 -DRFCLGQLSNVHRTEAIERA---------RLHIGKGVQLECKGE--GDVWVRCLSDHAVFVQSYYLD------REAGRAPGDAVHKIYPS--AYIKVFDLRQCHRQMQQQAATA Mus_musculus_Smad5 KSRFCLGLLSNVNRNSTIENT---------RRHIGKG-VHLYYVG--GEVYAECLSDSSIFVQSRNCN------FHHGFHP-TTVCKIPSS--CSLKIFNNQEFAQLLAQSVNHG Mus_musculus_Smad6 --GFCLGQLNL--EQRSESVR-------RTRSKIGFG-ILLSKEP--DGVWAYNRGEHPIFVNSPTLD------APGGRA--LVVRKVPPG--YSIKVFDFERS-GLLQH--AD- Mus_musculus_Smad8 RNRFCLGLLSNVNRNSTIENT---------RRHIGKG-VHLYYVG--GEVYAECVSDSSIFVQSRNCN------YQHGFHP-ATVCKIPSG--CSLKVFNNQLFAQLLAQSVHHG Mus_musculus_Smad9 RNRFCLGLLSNVNRNSTIENT---------RRHIGKG-VHLYYVG--GEVYAECVSDSSIFVQSRNCN------YQHGFHP-ATVCKIPSG--CSLKVFNNQLFAQLLAQSVHHG 'Nematostella vectensis Smad1/5' SERFCLGLLSNVNRNSTIENT---------RRHIGKG-VHLYYVG--GEVYAECLSDSAIFVQSRNCN------HSHGFHP-TTVCKIPSG--CTLKIFNNQEFAQLLSQSVNYG 'Nematostella vectensis Smad2/3' SDRFCLGLLSNINRNPPIEMT---------RKHIGKG-VRLYYIG--GEVFAECLSDSSIFVQSPNCN------QRYNWHP-ATVCKIPPG--CNLKIFNNQEFAQLLSQSVNQG Nematostella_vectensis_Smad4 -NRFCLGQLSNVHRTEASERA---------RLHIGKGVQLDVRGE--GDVWVRCLSEHSVFVQSYYLD------REAGRCPGDAVHKIYPS--AYIKVFDLRALLPQMGQTSVGV 'Nematostella vectensis Smad6/7' --GFCLAGLDRNQNVSDGTKR--------ARNHVGFG-LQLSREE--DGIWIYNRSEYAVFANGTTFPYVTTTPSAS---QNITVTKVPPG--FSLKIYDYNHS--PATCRTFEG 'Oscarella carmela Smad1/5/8' SDRFCLGLLSNVNRNSTIENT---------RRHIGRG-VHLYYVG--GEVFAECLSDSAVFVQSRNCN------HHHGFHP-STVCKIPHG--CSLKIFNNQEFAELLSRNVNEG Oscarella_carmela_Smad4 -GRFCLGQLSNVHRAEQIERV---------RLHIGRGIQLDSRSN--GDVWLRCLSEHSVYVQSYYLD------QEAGRAPGDAVHKIYPN--AYIKI--------------ANE 'Saccoglossus kowalevskii Smad1/5' SDRFCLGLLSNVNRNSTIENT---------RRHIGKG-VHLYYVG--GEVYAECLSDSSIFVQSRNCN------YTHGFHP-TTVCKIPPG--CSLKIFNNQEFAALLSQSVNHG 'Saccoglossus kowalevskii Smad2/3' SERFCLGLLSNINRNQTIELT---------RRHIGKG-VRLYYIG--GEVFAECLSESSIFVQSPQCN------LRYGWHP-ATVCKIPPG--CNLKIFNNQEFAALLSQSVNQG Saccoglossus_kowalevskii_Smad4 -DRFCLGQLSNVHRTEASERA---------RLHIGRGVQLDLRGE--GDVWVRCLSDHAVFVQSYYLD------REAGRAPGDAVHKIYPN--AYIKVFDLRQCHQQMRQQAATA Saccoglossus_kowalevskii_Smad6 --GLCLGLLDR--ECRTESVI-------RTRTKIGYG-VTISREQ--DGVWAYNRSNHAMFVNSPTLD------TPNSRT--LSVWKVSPG--YSIRIFDYEKS-ELLRRTRNPE Tribolium_castaneum_Smad1 SDRFCLGQLSNVNRNSTIENT---------RRHIGKG-VHLYYVN--GEVYAECLSDSPIFVQSRNCN------HHHGFHP-SAVCKIPAG--CSLRIFNNAEFAQLLSQCVNHG Tribolium_castaneum_Smad4 -NRFCLGALSNVHRTDQSERA---------RLHIGKGVQLDLRGE--GDVWLRCLSDHSVFVQSYYLD------REAGRQPGDAVHKIYPS--AYIKVFDLRQCHNQMTTQAATA Tribolium_castaneum_Smad5 -DRFNLFEKENAGREWTVKNT---------RQQIGRG-ITLHYVK--GQIYVQLWSDSDLYVNSRFYN------RLKNYPG-GTICKLSPFRCRHMKLFRDDEFHEMLSAEVAKG 'Tribolium castaneum Smad6/7' --GLSLETLAQQNCNAPESVR-------HGRCKIGLG-VTLSHEG--GSVWVYNRSENPIFVNSVTLD------SADS----PLPTRVPAE--QCLCVYDPQK--AAAHRTCWDF 'Trichoplax adhaerens Smad1/5' ADRFCLGLLSNVNRNSTIENT---------RRHIGKG-VHLYYVG--GEVYAECLSESSIFVQSRNCN------YHHNFHP-TTVCKIPSS--CSLKIFDNQDFAALLSESVSKG 'Trichoplax adhaerens Smad2/3' SERFCLGLLSNVNRDPTVEMT---------RREIGKG-VRLCYVH--GEVFAECCSKHAVFVQSPNSN------RRYGWHP-AAVCKIPPG--SSLRIFNSQEFANLLSQSVTQG Trichoplax_adhaerens_Smad4 -NRFCLGQLSNVHRTKESERA---------RLHIGKGVRLECHGE--GDVWLSCLSEHSVFVQSYYLD------REAGRGPFDYVHKVYPK--AYIKVFDLQLCYQQMQQEASKA 'Trichoplax adhaerens Smad6/7' --GFWLGALNRDGVSGNISNTDSNQCDSRVFHRIGYG-LQLSRED--DSVWIYNRSEHPLYVNSPLYN------KNIQSTHNTEVKKVQPG--YSLKVFNYARV-DMPQQIRP-- ; END;