#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 18, 2025; 21:23 GMT TreeBASE (cc) 1994-2008 Study reference: Li G., Jiang L., Ni J., Liu Q., & Zhang Y. 2014. Computational identification of a new SelD-like family that may participate in sulfur metabolism in hyperthermophilic sulfur-reducing archaea. BMC Genomics, . TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S16227] BEGIN TAXA; TITLE Untitled_Taxa_Block; DIMENSIONS NTAX=46; TAXLABELS HypE_Escherichia_coli HypE_Geobacter_metallireducens HypE_Methanocaldococcus_jannaschii HypE_Methanococcus_maripaludis HypE_Mycobacterium_rhodesiae HypE_Sulfolobus_acidocaldarius PurL_Geobacter_lovleyi PurL_Methanococcus_maripaludis PurL_Methanosarcina_acetivorans PurL_Moorella_thermoacetica PurL_Pyrobaculum_islandicum PurM_Escherichia_coli PurM_Geobacter_lovleyi PurM_Methanosarcina_mazei PurM_Shewanella_oneidensis PurM_Sulfolobus_islandicus PurM_Thermococcus_barophilus SPS2_Caenorhabditis_elegans SPS2_Danio_rerio SPS2_Dictyostelium_discoideum SPS2_Mus_musculus SelD_Archaea_Haloterrigena_turkmenica SelD_Archaea_Methanocaldococcus_jannaschii SelD_Archaea_Methanoplanus_petrolearius SelD_Archaea_Methanopyrus_kandleri SelD_Bacteria_Ammonifex_degensii SelD_Bacteria_Escherichia_coli SelD_Bacteria_Ralstonia_eutropha SelD_Bacteria_Syntrophomonas_wolfei SelD_like_Acidianus_hospitalis SelD_like_Caldivirga_maquilingensis SelD_like_Metallosphaera_cuprina SelD_like_Pyrobaculum_aerophilum SelD_like_Sulfolobus_tokodaii SelD_like_Thermoproteus_uzoniensis SelD_like_Vulcanisaeta_distributa ThiL_Acidothermus_cellulolyticus ThiL_Escherichia_coli ThiL_Mariprofundus_ferrooxydans ThiL_Methanocaldococcus_jannaschii ThiL_Methanococcus_vannielii ThiL_Vibrio_shilonii other_Methanobrevibacter_smithii other_Methanococcus_maripaludis other_Methanopyrus_kandleri root ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M23571] TITLE 'Multiple sequence alignment of APT-binding superfamily'; LINK TAXA = Untitled_Taxa_Block; DIMENSIONS NCHAR=1202; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 ] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] HypE_Escherichia_coli ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-------NNIQLAHGSGGQ--------------AMQQLINSLFM------EA--FANPWL-AEQEDQARLDLAQL---------------------------------VAEG-DRLAF-----------------------------STDSYVIDPLFF----PGGNIGKLAICGTANDVAVSG--AIPRYL-SCGFILEEG-L----------------PMETLKAVVTSMAETARTAGIAIV-TGDTKVVQRD-AVDKLFINTAGMGAIPANI----HWGAQTLTAGDVLLVSG----TLGDHG--ATILNLREQLG------------LDGELVSDCAVLTPLIQTLR-DI-----------------P-GVKALRDATRGGVNAVVHEFAAACG-CGIELSEAALPVKPAV-RGVCELL----GL-------D-------------ALNFANEG---KLVIAVERNAAEQVLAALHSHPLGKD------AALIGEVVERKGV--R--LAGLYGVKRTL----DLPHAEPLPRIC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HypE_Geobacter_metallireducens --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNK-------DLILLGHGSGGK--------------LSHQLLDDLII------PT--LSGIPL-AGQNDAAVV--------------------------------------EHGG-QRLAF-----------------------------TTDSYVVDPIFF----PGGNIGSLAVNGTVNDLAMMG--ARPLFI-SAGLIVEEG-F----------------SRTELAGILASMRGAADAAGVRIV-TGDTKVVPRG-KADRIFINTSGIGAVEHDF----AINGANARAGDVVIING----TIGDHG--IAVMAEREGLD------------LRTAIRSDCAALNDLVAEII-AA---------------GGD-AVHVLRDPTRGGVATTLKEIALQSD-KTITLREETLPLNGAV-KGVCSIL----GL-------D-------------PLYVANEG---KLLAVVAPEAAERVLTRIKGHRLGRD------AAIIGHVAEGGG---RVQMETAVGGMRAV----EMLAGEQLPRIC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HypE_Methanocaldococcus_jannaschii ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKITRMHGAGGK--------------VMQELIKDVIL------KN--LEITSVNGGIGLESLDDSATI---------------------------------PIGD-KEIVF-----------------------------TVDGHTVKPIFF----PGGDIGRLAVSGTVNDLAVMG--AKPLAL-SLSLIIPEG-F----------------NLEDLEKIVKSINETSKEAEVAII-TGDTKVSDG---VDDIIISTAGIGIVDRGK----AIRDCNVQEGDAIIVSG----NIGEHG--LAILLSREGFD------------FETNIKSDVAPINKLIERVL-EE----------------GI-QINAMKDPTRGGLADALNEMAEKSN-IGITIFEDKIPISDEV-QSICDIL----GL-------D-------------PLTIANEG---KVVMAVKKEDAERCLEILREHPLGKN------AEIIGYATKEHKG--V--IIETIVGRRIV----DMPIGDPIPRVC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HypE_Methanococcus_maripaludis ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNITRMHGAGGT--------------VMQKLIKETIL------GN--LENTKIEGGIGLESLDDASTI---------------------------------PLGD-KEIVF-----------------------------TVDGHTVQPIFF----PGGDIGRISVCGTVNDLSVMG--AKPVAL-SLSIVLPEG-F----------------DIEKLDKIMKSINEACKEAGVAII-TGDTKVS-N---VDDIIISSAGIGLVDSGK----AVRDCGMREGDVIIVTG----NIGEHG--LTILLTREGFE------------FESDLKSDVAPVNGIVQSVL-NA----------------GF-EINAMKDPTRGGLADSLNEMAEKSD-LGILIYEDQIPISDEV-QAIGEAL----GI-------D-------------PLTVANEG---KVVMSVNEKDSEKILEILKAHPLGKN------AKIIGNVTSEHKG--V--LMETIVGKRIV----DTPMGDPIPRVC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HypE_Mycobacterium_rhodesiae ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPDTPAEADTAIDMESWVCPAPLRDS-------PNIVMGHGGGGA--------------MSAELIEHLFL------PA--FGRAAE-AGMGDSAVL--------------------------------------DVGN-VRLAF-----------------------------STDSFVVKPLSF----PGGTIGDLAVNGTVNDLAMAG--ARPLVM-STAFILEEG-T----------------SLDDLARVAQAVGTAAMAAGVKLV-TGDTKVVDAG-HGDGVYINTAGIGLIDERA----DIRPQRATEGDVVIVSG----DIGVHG--VAVMSCREGLE------------FGTTVASDTAPLHGLVAAMI-DT----------------GA-DIHALRDPTRGGVAATLNEIAKTAD-VGISLDERTFPIPAEV-RDACGLL----GL-------D-------------PLYVANEG---KLLAFVAPTEADRVLTAMRAHPLGAH------ATVIGRCVAEHPK--MVSAKTALGGTRVV----DLPIGEQLPRIC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HypE_Sulfolobus_acidocaldarius -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--------------RFGKLNPKAFL------HRLPIGNCVVCPGIG----EDDAYV---------------------------------KVEG-EYLVI-----------------------------HSD-----PITE----TGKDAGYLSVVVACNDVNMKG--VECKSI-ITTLLLHD--------------------EESLSPVIEGISEACNILKCKVV-GGHTELTKG---LDRDIVVTTAFSFSNH------VLRLSDVRENDYIVLFG----NPGIEG--TWILANEYEDKL-------SRLGVSRNLIERAKRFKYLIPVQD-KAMK-------------VKD-YAISMHDATEGGIYQALLEVAQATN-LRVVVEKEKIPLLEET-VEITKAL----NI-------N-------------PYTLISSG---AFIVITRD---YEKLTRLGGVLIGKLKRDTPALEVNGEVYTEDFEEELVRFEGYNNGGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PurL_Geobacter_lovleyi ----------MSSRVEVALKDGVRDSRGERIKREIEHFLHLKVKQVRTIDVYTVDAALTREELEAAASGPFCDPVIQSYSVDLPQASGFDWAVEVGFRPGVTDNIGRTAGEAVSYLIQRPLADSEAVYSSVQYLLTGDLSNEQVEKIATGLLCNTLIQRYSIMSAADFMARRGFPVTVPKVTGETKGQVREIDLEVSDEELLRISKDGVLALTLEEMKIIQTHYRDPQVLAERSKQGLGSKPTDVELECLAQTWSEHCKHKIF-------AGTVQYEDENGN------------KQEIKSLFKSYIQRVTKEVRQNMGDKDFCLSVFK----DNAGVI---------------------------------TFDENNSLVF-----------------------------KVE-----THNSPSALDPYGGALTGIVGVNRDPFGTGQGSKLIFN-TDVFCFADP------FYDKPLPARLLHPRRIFEGVVEGVEHGGNKSGIPTV-NGSIVFDERF--AGKPLVFCGTAGMMPAR-VNGIPGHEKSIKPGDLIVMAGGRIGKDGIHGATFSSEELNENSP------------VTAVQIGDPITQKRMFDFLI-RARD---------------KGLYRFITDNGAGGLSSSIGEMAGECN--GCRMDLAKAPLKYP-------------GL-------N-------------PWEILISEAQERMSMAVPPEKLDEFMAMSKR--------FGVESTVLGEFTDSGTFH-----IQYGEATVAW--LPMEFMHEGLPPMQIPAKWQPPVTPEA-----PAQHKEDWTADLLGLLGQLNICSKESVVR-RYDHEVQGGSVVKPFTGVTNDGPSDAAVVRPILDSYKGVVVSHGICPRYSDIDAYHMAANAIDEALRNYVAVGGNPEHWAGLDNFCWCDPVLSEKTPDGPYKMAQLVRANQALLDYCVPLNLPLISGKDSMKNDFYD-----GSTKISIPPTLLFSVIGTIPDIRNAVTMDFKRPGDIICLLGATKDELGGSEYLAM-QGYTGNKVPKVDLASALARYKALHQAIMNGLVASCHDLSDGGLAVALAESSFSGGFGCRVELGNVHFEGDQRYRTDEVLLFSESASRLLVTVHPAQWSAFEE--AMAGTTFSQIGQVADTDMVSIAGLEGKTVLHSSLKQLKEAWQATLREL--- PurL_Methanococcus_maripaludis MQTINAENNGKIYRIEIDTKEKSSEATG--IEKKLSELGY--DVSVDVSKVYTINYDFSIEDVEKI-ANSLHNPVTEIPRINVPSNNKFDWTLELGFLPGVTDNVANTTTEIINDLLKINIGLS-KVFSSKVVYLSGNLAKHDVEKIAEE-LINILIERYHIKTYDNYVKDCGMDYIIPKVNLTSEPKVIEISLNVSDDELIEIGKKGILDPETGERRGPLALDLDYITAIKKYYQKEGRNPTDIELEALAQTWSEHCKHTIF-------ASQIDDIE--------------------EGIFKKYIRNATNEIREELGEKDFCISVFS----DNSGGI---------------------------------IFDDEWMVTD-----------------------------KAE-----THNSPSALDPFGGAITGIVGVNRDTVGFGLGALPVAN-KYGFCVGRPEDTKIIYRGQNKSNPSLLPRRILDGIVHGVNVGGNQSGIPTP-NGFVYFDDTY--KGKPLVFVGTIGLIPRKLPDGRLSHEKAAENGDNIVIIGGRVGKDGIHGATFSSEAMDEGSP------------ATAVQIGDPITQKKLSDAVIKEARD---------------RELYNSITDNGAGGISCSVAEMAEECG--GFVVELEEVPLKYP-------------GL-------E-------------PWEIWISESQERVTLSVSDDKLEEFMDLMKI--------RGVEAVVIGKFNNTDRAV-----VNYNGKTIMD--LNMDFLHNGLPKRKLITKPYPYKTEE------PEITVKNQLKTFEKILGNHNNCSFEYISK-QYDHEVQNNSVIKPLQGKGRV-NGAASVIRPLLSSQKGLVMSQSLFPRLSEISCYDMAACALDTAIRNCVAVGGNINHIAIMDNFCWCS-------SDEPERLYQLKDAAKSCYDYAKIYLTPLISGKDSMFNDFKGFDENNNQIKISVHPTLMMSALGVIDNVEKTNSMDLKLKDDLIYVIGETKDECGGSEFYHA-FGEVGGKSPKVDAKSARKLYEKMYELSQKGIFSSCASVAAGGLAITLAKMAISGMLGLEADLSKAPNEN----LDFGKIMYSETQSRFIVTIAPENEKEFEN--LMKEFKIGKIGKVTEKEFVIKN--NEDIVITSSLENMDEVYRSRFEDF--- PurL_Methanosarcina_acetivorans --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLPEEDLKIIRKELGREPTLVEQGCFLNLWSEHCSYRSS-------APLLKTF---------------------------------------TSTGENVLIGPG----DDAAII---------------------------------KFEDGYVLAI-----------------------------GME-----SHNHPSYVDPYNGAATGIGGIVRDIISMG--ARPIAL-MDPLYFGPLDTPK--------------NLFLFEQIIKGIAGYGNCIGVPVV-NGETFFDRRY--SGNPLVNVVAVGLCKEEN----VTTSRSQKAENKLILAGSSTGKDGLGGASFASRDLSESAEA---------EDRPSVQVGDPYTEKLVMEMTL-EAIE---------------KGYVKSCKDLGAAGLGGASSELAAKGG-LGARIIADAVPQREP-------------NM-------N-------------AYEILLAESQERMLFEVAPEDVDAVLALVQK--------YDLNGAVVGYLTKEPTYT-----VEFGGEIVAD--IPIAFLTGGAPTCEKPSEAPTLREEGK-----KPETPEDLKVAFLKVLSSYNIASKEWIYR-QYDHEVQLRTVVKPG-------EDS-GVLR-I-TGTKGIALTCGCQPRATLLDPYNGGKTAIIENSMNLAVKGAEPLAIVNCLNF---------GNPERPETYWQFENAVLGLGDEARKLSIPVVGGNVSLYNESDEF-------KTAIPPTPSIGMIGKVDLEIPLPSGFFAKDGDSIILVGETTPEMGGSEYYACMDSGNAGMVPAVPENAPELIKAII-EAVKSGKLSSAHDLSLGGIGAGLARMCRSM--GAKVDLSELA-GE----TQADELLFSEAPARALLAISEPEAVRE----ILKDVPHAVIGKVGGETLEIKG---KNFELSVSLKEIAEAYGSLTRFMMG- PurL_Moorella_thermoacetica -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEPEIYRRMGLTDAEFEKVKAILGREPNYVELGMFAVMWSEHCGYKSS-------RSVLKLF---------------------------------------PTKAPWVLQGPG----ENAGIV---------------------------------DIGDGQAVVF-----------------------------KIE-----SHNHPSAIEPFQGAATGVGGIVRDIFAMG--ARPIAV-LNSLRFGPLDDSR--------------TRYLMGGVVGGIAFYGNCLGLPTV-AGEVYFEPSY--ACNPLVNVMAVGLIEQKN----IRRGTAAGVGNAVMLIGARTGRDGIHGATFASEELSEASE----------ERRPSVQVGDPFREKLLIEACL-EIIN---------------EDLIIGMQDMGAAGITSSSCEMAARAG-TGMEIDIALVPRREE-------------GM-------T-------------PYEVMLSESQERMLLVPKKGAEERIRAICRR--------WGLEAVIIGRVTGDGLMR-----IMENGRVVAE--VPAKALTDQCPVYERERRRPAYLDEVRQRDLSRLPEPEDYGRVLLGLLAAPNLASKEWVYR-QYDYMVRTDTVAGPG-------GDA-AILR-VKGTSKGLALTVDGNGRYCYLDPERGGAIAVAEAARNLACVGARPLAITDCLNF---------GNPEKPEVAWQFYQAVSGMSRACEVLRTPVTGGNVSFYNETES---------GAIYPTPVVGMVGLLPDIEKRCGIGFRREGDLLILMGETYPEIGGSEYLATFHGLVAGEPPALDLEREKAVQALVREVIAAGLATAAHDCAEGGLAVALAESALAGGLGAEVEL---A-SD----LRPDFLLFSESQSRILLAVAPEARDRVLDLAREKGVRASVIGRCGGHSLVVRI--NGRTLFNLSLEEMGKQWRESIPVLMAR PurL_Pyrobaculum_islandicum -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGLTQRELEIIRERLGREPTAAELAFFTSHWSEHCSYKST-------KMWLREL---------------------------------------PGSAPWVVRGRG----TDAPLV---------------------------------EVAHGLYVSF-----------------------------KIE-----SHNHPSAVDPYNGAATGVGGIIRDILTVG--ATPIAL-LVNLHFGPPEDPH--------------AKWIFSNVIKGISDYGNRVGVPVV-GGETWFDEDF--TYTPIVLATCVGVVEAEA----VP-KGYVEPGDYIVVAGLGADRSGLGGSAFASKTLEGGED------------LGAIQVADPLMGKKLIDVVK-EV-----------------SRCVKFIKDLGGGGLATALAELSHWFS-LGVEFHLDKLHVRDA-------------SA-------L-------------PEELLISETQERLIFVISPRDLPCLEEALRK--------YEVPYSIPGRFVKSDRVL-----VMWKGVKIVD--IPIS-LADGAPEILWPQEP------YQPSDIPEIPEPPID-KAIDIVLSSPNVAKKESIYM-RFDFDVGVRTAVKPG-------EGDAAVLKLYQRGQLGLVVKGDANPRYTFLDPRLGAANAFVKAYRNVAVVGGVPLAAVDSINV---------GSPERPQVYWRFVQAVQGLKEAATELEVPIVGGKVSLYNEYMG---------RPIKPTVAVVVLGKIDDVSKAN-RALWHDGDKIYIWGVTKGEVGGSEYLKRVHGILAGRPPSIDYAAEKEIVAVIQS--WLGKISGATDVGLGGLITALAKMAINSGIGGEIDVCKAPAET----TRLDYLLFSESNGRFIATGAEGPGVA-----IGEAYGEEFVVKCGGTLIYKRG--VEELKRLMSL----------------- PurM_Escherichia_coli --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTDKT--------SLSYKDAGVDIDAG-------NALVG---------------------RIKGVVKKTR-------------RPEVMGGLG----GFGALYALPQ-----------------------------KYRE-PVLVS-----------------------------GTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQG--AEPLFF-LDYYATGK--L----------------DVDTASAVISGIAEGCLQSGCSLV-GGETAEMPGMYHGEDYDVAGFCVGVVEKSE----IIDGSKVSDGDVLIALG----SSGPHSNGYSLVRKILEVSGCDPQTTE--LDGKPLADHLLAPTRIYVKSVL-ELIE---------------KVDVHAIAHLTGGGFWENIPRVLPDN--TQAVIDESSWQWPEVF-NWLQTAG----NV-------ER-----------HEMYRTFNCGVGMIIALPAPEV-DKALALLNA--------NGENAWKIGIIKASDSEQRVVIE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PurM_Geobacter_lovleyi ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSKP--------RATYKEAGVDIEAG-------NSFVQ---------------------KIKPLVKSTF-------------RPEVMTEIG----GFGGLFSLNAA----------------------------KYKN-PVLVS-----------------------------GTDGVGTKLKLAFLADRHDTVGIDLVAMCVNDIVVQG--AEPLFF-LDYLATGK--L----------------DPDKAAQIVAGIAEGCRQAGCALI-GGETAEMPGFYADGEYDIAGFTVGVVEKDQ----IIDGSSITVGNKLIGIG----SSGLHSNGYSLARRIIFDRMGLAINSPLPDSTKTVDEELLTPTRIYVRSVM-NLLK---------------DFRINGIAHITGGGLLENVPRILPKG--CSASFKLGSWDMPSIF-TTLQEAG----NV-------EQ-----------NEMYRTFNMGIGMVLAVAAADV-DDILSRLNG--------LGEQAWLIGEVKSMSKNQTEQVVLV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PurM_Methanosarcina_mazei ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSEK--------HLTYADSGVDIKEE-------EKTVK---------------------TLID----KLS-------YVRKGIGAPLTGIG----HYAGLL---------------------------------DFGE-YALAM-----------------------------TTDGVGSKVLIANEMQRWNTVGIDCIAMNVNDLLAIG--AEPVAF-VDYLALEK--H----------------EEGFAEQIGEGLLKGAEISRMSIV-GGETATLPDIIKG--FDLAGTCLGYLKKED----IIEGGRVRVGDVIVGIP----STGVHSNGYTLVRKIIQESGYYYHDPCPYDSSKTIGDDLLEPTRIYIEVLD-V-LK---------------ACEVHGLAHITGSGLLKL-RRVTKLG--FDFY---DPLEPQEIF-KFLQKEG----GV-------DD-----------LEMYRTFNMGMGFLIILPEKDA-AKAAEITG-------------GKIVGKIVESGIRVKDLVIE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ PurM_Shewanella_oneidensis --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSTPT--------PLSYKDAGVDIDAG-------NALVN---------------------NIKAAVKRTR-------------RPEVMGNLG----GFGALCELPT-----------------------------KYKQ-PVLVS-----------------------------GTDGVGTKLRLAIDYKKHDTVGIDLVAMCVNDLIVQG--AEPLFF-LDYYATGK--L----------------DVETATAVVNGIGEGCFQSGCALI-GGETAEMPGMYEGEDYDLAGFCVGVVEKAD----IIDGSKVAAGDALIALA----SSGPHSNGYSLVRKVLEVSQADPQQD---LNGKPLIQHLLEPTKIYVKSLL-KLIE---------------ASDVHAMAHITGGGFWENIPRVLPEN--CKAVIQGDSWQWPAVF-SWLMENG----NI-------AE-----------YEMYRTFNCGVGMIVALPADKV-DAALALLAA--------EGEQAWLIGAIAAREGNEEQVEIL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ PurM_Sulfolobus_islandicus ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--------SEEYKKAGVDLERL-------RNYHN---------------------AISQIISS--------------TYKNTIVGAG----HYSGVI---------------------------------KIGN-LNIAM-----------------------------HTDGVGTKTSLALQTGIIKPVGIDCVAMNVNDLICVG--AKPVAL-VDYIALEK--P----------------MDNVINEIINGIVQGAKDADVEVI-GGETAIMPDVIRG--FDLSCTAIGVVDNLK------TGVDIKPGDYILGLE----SNGIHSNGYSLVRKLIEEGK---------ISLDEYKRELLKPTRIYAKQVL-EVM-----------------NMIKGAAHITGGAFTKL-KRLTSYK--IVLN---MPEPP-EIF-KII-EKA----GV-------PH-----------EEMYKVFNMGIGIVLFISEELM-KEVKTKLER--------YGT-VYELGRVYNGNGITIKTYKNEILRV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PurM_Thermococcus_barophilus ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLTYAQAGVDERKA-------QKALR---------------------SIISLARKTFR-------FRRGKIGEPVEDIG----HYAALM---------------------------------DFGD-FYLAM-----------------------------TTDGVGTKILVAEAVGKFDTIGIDMVAMNVNDLICVG--AEPIAL-VDYLAVRD--P----------------NDKIFREIAKGLYEGAKQSGIAIV-GGETAVMPDLING--FDLAGTAIGIVGKEK----VITGNKIKPGDVVIGIE----SSGIHSNGLTLARKLLIPKYGLEYE----FEGKTLWEHLLEPTRIYVKPIL-ELLE---------------KVEVKGLAHITGGGLLNL-KRLTKYG--FSLE---MPPIR-GIF-KLI-YEN----GV-------PL-----------EEMFKVFNMGIGFVVIVSQGEK-EETLQILNN--------YYL-SYEIGKVIKKPKIKIENYKIMF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SPS2_Caenorhabditis_elegans ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNRIERILEGFDPVSNGLD-EDFVLTKLTGMKGCGCKVPRNVL-----LQLLQTFK--TDLVIN----------------------------------NDEVD-IG----LDSCVIP--------------------------------LRHPGLRLVQ-----------------------------TTD-----FFYPL-IDDPYIMGRVTCANVLSDLYAMG--VSECDNMLMLLAVAID-------------LNEKQRDIVVPLFIQGFKDAADEAGTKIR-GGQTVR------CPWLLLGGVATSVAHESE----IIKVDQAVPGDVLILTK----PIGGQVAVNSYEWIKKKNGKI---EE-LNLEIPKIEKAFKQVCEQMSRLNR-NAAKLLH------------KYDAHSSTDVTGFGLLGHAENLARVQK-QPMEFIIEKLPIIEYM-DEIADKMIAKGGE-------GFK-----------LYQGTSAETSGGLLIAMSEENAKKYIAELSSL-------DNAPAWIIGKVTAKTTDSSI--ARI----------LPDAVRISVPSHI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ SPS2_Danio_rerio --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-----SGSEPPSGDSGGAGGYAVFYPAGYQALNPEEHGLD-RGFRLTAFSDMKGCGCKVPQETL-----LKLLQGLE---PDRPPGEDGGLGTGVGDETADFGLVS------A----AQGPRLG-IG----MDSCVIP--------------------------------LRHGGLSLVQ-----------------------------TTD-----FFYPL-VEDPYMMGRIACANVLSDLYAMG--ITECDNMLMLLSVSQK-------------MNEKERDLVLPLMMKGFRDAAEEGGTSVT-GGQTVI------NPWIIIGGVASVVCQPND----FILPDGAVPGDVLVLTK----PLGTQVAVNAHQWLDIPEKWNK--IK-LVISREEVEQAYQEAMLNMATLNR-TAAALMH------------KFNAHAATDITGFGIIGHARNLAKQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SPS2_Dictyostelium_discoideum --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSISIKDKKEE-LLCRLTDFTKLKGCGCKVPQAEL-----LSLLDGIG--GGI-------------GYDCSISQTK-------------FPDIVM-IQ----TTDVSLKLFKNK----------NKLIKLYIYIYL----IYIYIFFIIFL-----------------------------KKK-----FFFPL-VDDPYFQGKIACANVLSDLYSFG--IEDCDNMLMLLACSTD-------------MTAEQRQWSSKLMKQGFNDQAICAGSKVS-GGQTVK------NPWPIVGGVATSILKTNE----FIKPVNAVPGDVLVLTN----PLGTQFCVNFHQWLSKPKRGEK--IN-TITNAKECEQVFNYATLSMAKLNR-VGAKLMK------------NYNAHAATDVTGFGILGHSTNLAQNQL-LPIRFEIHTLPIIKHM-KKLEDH----LNH-------PFK-----------LLKGTSAETSGGLLISMSRENAEAFCKEIYEI-------EKQPAWIIGDVID----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SPS2_Mus_musculus ------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAEA-------AAA------------GASGETM-----AALVAAEGSLGPAGWSAGRSFSNYRPFEPQTLGFS-PSWRLTSFSGMKGCGCKVPQETL-----LKLLEGLT--RPALQPPLTSGLVGGQEETVQEGGLST------RPGPGSAFPSLS-IG----MDSCVIP--------------------------------LRHGGLSLVQ-----------------------------TTD-----FFYPL-VEDPYMMGRIACANVLSDLYAMG--ITECDNMLMLLSVSQS-------------MSEKEREKVTPLMIKGFRDAAEEGGTAVT-GGQTVV------NPWIIIGGVATVVCQQNE----FIMPDSAVVGDVLVLTK----PLGTQVAANAHQWLDNPEKWNK--IK-MVVSREEVELAYQEAMFNMATLNR-TAAGLMH------------TFNAHAATDITGFGILGHSQNLAKQQK-NEVSFVIHNLPIIAKM-AAISK-----ASG-------RFG-----------LLQGTSAETSGGLLICLPREQAARFCSEIKSSKYG----EGHQAWIVGIVEKGNRTARI--ID------------KPRVIEVLPRGASAAAAAAPDNSNA---------------------------ASEPSS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_Archaea_Haloterrigena_turkmenica ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTDRSDV-ADVRLTEYADLHGCSCKVGRSDL-----DDLLREAG--LTE--SRDELL--------------------------------FG-VG----EDAAARQLT------------------------------D---DLALVS-----------------------------TVD-----FFTPI-IDDPYDFGRVAACNAASDAFATG--AVDNLDCLAVLGLPQ-----------------ELT-TAAPMILAGIADAIDGMGGVVA-GGHTII------SPWPFAGGAVSATAPPEE----LLTSQRATTGDRLYLTK----PLGTQSAMGALRVSDDEFVD----VV-AEAAGRSVRTIGDEAVAWMTTPNR-AAAVAAR-------------DVASAATDITGFGLVGQAEVLADNAD-VGIEV--TRLPVIEGT-EGLSALF-------------GYG-----------LEDGESAETSGGLLLSVPPSHTATLESRLDDA-------GVF-YRQIGRVTDGDGVSLR--DPT----------VEP--IARAER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_Archaea_Methanocaldococcus_jannaschii --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERGN-EKIKLTELVKLHGCACKLPSTEL-----EFLVKGIV--TDDDLLDKNIL--------------------------------VG-LG----DDASIIKRN----------------------------------GLVIAK-----------------------------TVD-----VFTPI-VDDPYIQGKIAACNSTSDIYAMG--LLDIVGVLAIVGIPE-----------------KLPIHVVREMLKGFQDFCRENKTTIV-GGHTIL------NPWPLIGGAVTGVGREEE----VLTKAGVKVGDVLILTK----PLGTQTAMALSRIPEEFKDL----IS---ITEEERDYIINKAIEIMTTSNR-YALKALRKAEERVG-----DKIANALTDITGFGILGHSNEMAKNSN-VLIEI--NLLPCIKRT-PELSRLF-------------GHA-----------LLDGYGAETAGGLLISAKEEYKDNLIDELEKA-------KCY-AFEVGRVVKKGEGKAV--LSK----------DVK--VIEI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_Archaea_Methanoplanus_petrolearius ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSDI-EKRKLTSIAPLFGCSCKLPETEL-----ETLLEDIN--IS----YSPEI--------------------------------LC-PG----DDAAVIKIN------------------------------D---DLAIIK-----------------------------TTD-----FFTPI-VDDPYIQGKIAACNATNDVYAMG--ATEIVGVLALLGIPR-----------------ELPLENARMMLKGFQDFCNSIGTSIV-GGHTII------NPWPFIGGAVTAISSPDK----IVYHSGAQPGDVLLLTK----PLGIQPAMASTRLSSEYSSI----IQ-STLDSDIVANAVNLAIECMTTSNL-NAAKAIN------------EVGANALTDVTGFGLYGHGLNIARKSN-VSLNI--DLIPIISGT-LELSALF-------------EHG-----------LEEGKSAETAGGLLMSVSEENLDEIIHSLNKY-------NVP-AYEIGTVKEKGNEHVV--IDN----------PEI--LEISSLSVKFES-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_Archaea_Methanopyrus_kandleri -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MS-RKKSLVEMADLHGCACKLPQGDL-----EDLLKGVE--LPE--EGGRVE--------------------------------VG-VG----DDAAVIRVD----------------------------------GGYVIQ-----------------------------SVD-----FFTPI-HPDPYTQGRIAANNSINDVFAMG--ATEVLSVLVVSGFPR-----------------ELPEEDAREMLQGFADQCREVDALIV-GGHTIM------NPWPILGGCVTGFAERY------VTVGGAEPGDVLYLTK----PLGTQPAMAALRLPEDVRKQ----F----LTDSELEEAVDLAVEVMTEPLK-DAAEAAL------------EVGVHAMTDVTGFGLKGHAGEMAEASG-VRVVI--ERLPVIPGT-TELSRAL-------------GYG-----------LERGESAETAGGLLVAVPEEHAEDLEDAFERR-------DVW-YRRIGRVEEGSGVEVR--GDV-----------EE--VEDYP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_Bacteria_Ammonifex_degensii ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-ERIRLTALTTSSGCAAKIGPGTL-----ARILQDLP---LIKDPRLLVG--------------------------------IE-TS----DDAGVYLLT------------------------------E---EIALIQ-----------------------------TVD-----FFTPV-VDDPFFFGQIAAANALSDVYAMG--GKPLTA-LNIICFPTA----------------CGDLEILAQILRGGAEKVKEAGVVLL-GGHSVE------DKEPKYGLAVTGIVHPAK----VLTNRGSRPGDRLVLTK----RLGTGIVVTALKA------------------DLAPAELVAEATQEMATLNQ-AAAEAMQ------------EVGVNACTDITGFGLLGHALEMARASG-VHLVIKASQLPLFPQV-LDFAAMGLIPAGAYANRQFVAERVEISPAVPPELQDILFDPQTSGGLLISVPAERLEALLEALKRK-------GVATVAVIGEVTEGPPGTIE--VIP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_Bacteria_Escherichia_coli ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSE-NSIRLTQYSHGAGCGCKISPKVL-----ETILHSEQ--AKFVDPNLLVG--------------------------------NE-TR----DDAAVYDLG------------------------------N---GTSVIS-----------------------------TTD-----FFMPI-VDNPFDFGRIAATNAISDIFAMG--GKPIMA-IAILGWPIN----------------KLSPEIAREVTEGGRYACRQAGIALA-GGHSID------APEPIFGLAVTGIVPTER----VKKNSTAQAGCKLFLTK----PLGIGVLTTAEKK------------------SLLKPEHQGLATEVMCRMNI-AGASFAN------------IEGVKAMTDVTGFGLLGHLSEMCQGAG-VQARVDYEAIPKLPGV-EEYIKLGAVPGGTERNFASYGH---LMGEMPREVRDLLCDPQTSGGLLLAVMPEAENEVKATAAEF-------GIE-LTAIGELVPARGGRAM--VEI----------R------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ SelD_Bacteria_Ralstonia_eutropha -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA-ESIRLTQYSHGAGCGCKISPKVL-----DVILAGSG--AQNLDPRLWVG--------------------------------NA-SR----DDAAVYAID------------------------------GDDSGRGVVS-----------------------------TTD-----FFMPI-VDDPFDFGRIAATNAISDIYAMG--GDPLMA-IAILGWPVN----------------VLPPEVAREVVAGGRKACDDAGIPLA-GGHSID------APEPIFGLAVTGMVDRMH----MKRNDTATAGCRLYLTK----PIGIGVLTTAEKK------------------GLLRPEHAHVARDWMCVLNR-PGSAFGR------------LAGVRAMTDVTGFGLLGHLVEMADGSG-LTARLDYAAVPVLPEI-RRYIDAGCVPGGTQRNFDSYGH---RIGTLTDEQRALLCDPQTSGGLLVAVEPAGEAAFLDACTRL-------GLD-LAPIGELAARGEHAVE--VA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ SelD_Bacteria_Syntrophomonas_wolfei ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-KQTRLTEMVRAAGCAAKIGPEAL-----ESILKDFP---LPVHPDLLIG--------------------------------IE-SR----DDAAVLKLD------------------------------E---EKALIQ-----------------------------TID-----FFTPM-VDDPFIFGQIAATNALNDIYAMG--GTPILA-LNVVCFPE-----------------CADLQVLRKILEGGLSKVLEAGALLV-GGHTVD------DNEPKYGLAVSGLVHPQK----IIANNGAQPGDLLFLTK----PLGNGVIATSIKA------------------EMVSGEAYKEAIKWMSMLNR-ESSQAMM------------EVGVNAATDITGFGLMGHLYEMAWGSD-VQVEVFADKVPFMEGT-LEYAGLGLIPGGAYNNRDYLKDKVEYAGNIDPLIRDLFFSPETAGGLLIAVAEKKAGELLQVMEKR-------GSF-CNLIGRVRGEHFSPIR--VRD----------SRG--AEGQNP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_like_Acidianus_hospitalis ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEEVFERFRKNLEVY-NKMGLNPLSLATGCAVKVDLIDTVYPALEKIKNKLE--NIEILPREDADIFITREKMEIKRIIGG-----------------GNFD----ADRGVSLIQVNQDTAGNPEKFANFLLKTYSSIRS-RRKLTIGKGHSIVTTIPSAEVAVLDLIKLDGSKINSYTLANNDTIQ-----IVDPLEDPGSQMQVDVAISNSLNDLFTKG--AYQNLKMLPLFDAPND--------------------DLKERIMKNYENYSEKYDIPII-NDIQPN------TKSLMLGATVLGESDHEL----PTYYDKVEEGDEIIVTR----PIGELAPINVYLWILVVPEVLELMES-RGISFKRLEKVKMEVIEQMRKPNI-PTAKVIYNYLPEFGKSFDRENYITMTTDVTGPGIFVI-KEFAEKAG-VDVRL--DKIPVIDEEIAEFATE--------------GF------------IIPNSTSGTNGATVVFYSRRISDDIIEDLQK--------EGLKPIKIGKVLGKGQGVVH--VNK----------DIERFIHRKNVLSHFKID------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_like_Caldivirga_maquilingensis ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKVSKEERMSRFLKHVSKY-ASIGVNLTSLALGCSVKVDLYNVLYPALSIVKRELGELHIKIAPREDVAVLRGSEL-DLMRVITS------VDSPKLPINTISDFN----PDALILLVESFQGNASDPDSFANIMIRLFKELAKVNKELVIGKGHSIVSTQPNASIHVLDFIKVKNKD-DAYTLVNNDTIQ-----VIDPMDEIASRRQVSVALNNALNDLFSKG--AFKDLEFYPVYDAPGE---------------------YKHGLFNEVKAYVNELGGRLH-DVEQPN------LGYLLIGSTVASRLDREP----PMFYNEVKEGFKIIVTR----PFGELSIIGTYVALHVDEELYDKFER-EVMTVDELEEIKEYALNQMAKPNI-DVAKVIYNHLPELGRRFNDDEHVAATIDISGPGIFVF-KELAETAN-VKIRL--SNIPLISPEVAEFAAS--------------NY------------IISDATAGTNGAVALVVSSGLVDDVLDELGKI-------PGLKPMVIGEVVGRGEGTLI--VPD----------YVTRYIKDKVMLTKLTIASNILQGVSRQ------------------------AALRLARAEIMVTGKVQGV-GFRPLVRRNAKSLGLTGFARNNEDGSVLIIVEGEE-----------GNIKAFIESLRNI------NIAEVRELNIKWSS-----------------------------------------YKGEFQDFTIE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_like_Metallosphaera_cuprina --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAMSDLFERFRDNLNKY-KKMGINPLSLATGCAVKVDLIDTVYPALEKLKEKLLANNIEVMPREDTDIFVSRESEVLKRVING-----------------GEFD----ADRAISLIQVNQETAGNPEKFANFLLKIYTGVKT-RRKLIVGKGHSIVTTNPKAEVGILDLFKLDGRELRSYTLSNNDTIQ-----IVDPLDDPGSQMQVDVGVSNSLNDLFTKG--AFQDLKMIPVADAPDP--------------------DLKKTLLNNFERFSKRYNVELL-TDVQPS------TGTLMIGATVVGKSDHEL----PTYYDKVDEGMEILVTR----PVGELTPINVHMWLLTVPELIDTMEE-RGITLNKVEEAKKRALDYMTKPNF-DSAEVIYNHLPEFGGKFDLESHVAMTTDVTGPGIFVV-KEFAEKAL-VDVDL--YDVPVIDREISEFATE--------------NF------------IIPNSTAGTNGAIVIFASKKVIDDIAQDLTK--------RGLEPRIIGRVLRKGTGVVY--VKK----------DVCKLIHRENILKHFKVRDAN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_like_Pyrobaculum_aerophilum -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNRLERFKERVKLY-REAGIALESLSLGCSVKVDLYNVLYPALQLLREEMYKLNLVIAPREDAAIMPGASA-ALRRYFLD------VENPRLDPAEVEKLS----PTVAIVLAQVYMGKAAAPDLFAKYVAGLYKALGSSRHKVWLGKGHSIISTKKGAEFFMVDFLKAEGQ--EGYIVANNDTIQ-----VIDPSEDFDSPLQIAVAVNNALNDLFTKG--AWKDIHIAPVYDAPPP---------------------FRGPLEARVKSYASSLGKLV--EAPQPE------MGYLLLGATAYARLDREP----PLFYDKIREGFVVVVTR----PFGELAYFTTYVAVHTDETLMKKFEE-EVMPIEQFEAEKRRVLEIMATPNL-EAAKAIYQYLPDLGERFDPEAHIAATIDVSGPGIFVF-KEVAERAG-VDIRL--FDVPLMSSAVSKFAAD--------------NY------------IMPDATAGTNGAIAIFASRKVAEELVEKLSKA-------PHAKPTVIGVVEGKGEGRLI--VPE----------WALQYISSKKLREKL-GAASVLGGLARV-------------------------VGRPIRAVAYVEGAVQGV-GFRPMARARAKALGLLGYAKNLPDGRVEVVVEGDE-----------ERVRKYVEELCKG-------FENCRVGQVIYAE-----------------------------------------ARGEFSDFSIL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_like_Sulfolobus_tokodaii -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHSNMDIFTKFKENLEVY-KSMGLNPLSLATGCAVKVDLIDTVYPALEKIKKILEERNITILPREDADIFVSREKMEMKRLING-----------------GEFD----ADRAITLIQVNQETAGNPDAFSEFLVRVYTSIKT-SRKLTIGKGHSIVTTKKDGEVAVLDLFRLEGREEKSYTVANNDTIQ-----IVDPLDNPGSQVQVDVAISNSLNDLFTKG--VFQELTVVPVVDAPNS--------------------ELKKKLLSNYENYVKKYNMNLR-NDIQPS------VGTLMMGATVVGKSDHEL----PTFYDKVNENMVIITTR----FFGELTPINVHLWSLAVPELIEMMES-RGISFSRIEKVKSEALEIMRRPNI-HVAKVIYSYLPEFGKSFDEKSHIAMTTDVTGPGIFVI-KEFAEKAK-VDVEL--NDIPVIDRDICEFATE--------------NF------------IIPNSTIGTNGAIVMFADKRIADDIMEDLIK--------VGEKPEIVGYVKGKGNGTVY--APK----------DVMKLIRRDNVLKQFKIKE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ SelD_like_Thermoproteus_uzoniensis -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNPVEKFRERVRLY-REAGIALESLSLGCSVKVDLYDVLYPALELLRDDVRRLNLVIAPREDAAIMRGAGA-ELRRLYLD------PEDPHIDPAFLESYA----PDLAVVLVQLYMAKAATPSKFAEYAARLYKALGSSRHRVWLGKGHSIVSTKKGAEFFMVDFLKAEPG--EGYVLANNDTIQ-----VIDPSEDFDSPLQAAVAVNNALNDLYVKG--VYKDVEIAPVYDAPEP---------------------YRARVKAAVESHAASLGRLV--EAPQPG------RGYLLLGATAYGRLDREP----PTYYSQLGEGFVVLVTR----PFGELAYFTTYVAVNTDEELLKAFEK-SVMPLDQFEKEKRRVLELMAAPNA-DVARVIYDHLPDLGERFDPEAHIAATIDISGPGVFVF-KEVAERAG-VDVEL--WDVPLLGPSVSRFAAE--------------NF------------IMPDATAGTNGAIAVFLHKKLADEVLDELSKI-------PRLRPAVVGRVLGKGEGRLA--VPR----------EALAYISSEKLREKLVGAAQVLGGL----------------------------AGKAVRARAYLEGDVQGI-GFRPTARAKARALGLTGYAANLPDGRVELVVEGDR-----------DRVEKLLQELCAR-------F-NCRVAELAWEP-----------------------------------------AEGAYKDFEIR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_like_Vulcanisaeta_distributa -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEMRDDRIRVFRERLDKY-LDLGINLLSLAIGCSVKVDLYDTLYPALSLVNNEIAKLNIEIQPREDVAVLRSNGDYSLVRRIYD------ITGNGVNKDELVSIN----PSVALLLLQVHQSRASSPREFASSIISLYRRLGSSPVRVRIGKGHSIVSTKEKAEFALIDFISTKSG--DGYLLANNDTIQ-----IIDPTEDPGSYRQVATAVSNALNDLFIKG--VYRDITIYPVYDAPIE--------------------DLKEKLMKNFREFSSKWDLQLSTDVQQPR------VNYLLMGATVVGTLDREP----PMFYDNIKAGFKILITR----PFGELSIISTYLTAHVDESIMDELER-NVMSIEDLEKLKIKIMDILSRPNI-EIARVISKYLPEIGEAFREDEHIAATIDVSGPGIFVF-KELAEQAN-VDVAL--YNIPLISPEVARFAAE--------------HY------------IITDATAGTNGAIAIVASKDVIDSIVRDLRGI-------EDVQPMVIGEVMGKGSGRLF--VPD----------YVTRYITSKSLLMKLTMNIDVLRSLRRQ-----------------------QVKCEKVRVEARVFGNVQGV-GFRPTLRRQALSLGLTGYVRNLPDGSVEVVAEGCK-----------EDVMALIEWIRSS------PVGSVETINYVIKQ-----------------------------------------YFGEFEDFEIR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ThiL_Acidothermus_cellulolyticus ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTSNAATLLGPG----DDAAVV---------------------------------AVPD-GRVVV-----------------------------TTDLLVDGRHFRRDWSTPYDVGRKAAAQNMADIAAMG--AVPVAL-VVGLATPPD-I----------------PAFWAERLADGLREEAARTGAAVV-GGDVVR------SDTVVVAVTALGDLQGRT----PVTRGGARPGDVVAVIG----RLGWAEAGLAALRRGFRT--------------------PRAAVEAHRRPEP-PYEAGP-----I-----AADRGATSMIDVSD-GLLGDLGHVAVASR-IRIDVESAALPVADVV-AEVAAAC----GV-------D-------------PLRWVLTGGEDHALAATFPDR-AAVPDGW---------------VVIGRAHEPAGETGDVVVDG---RRYPG----SGFSHFAADA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ThiL_Escherichia_coli ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MACGEFSL-------------------IARYFD-------RVRSSRLDVELGIG----DDCALL---------------------------------NIPEKQTLAI-----------------------------STDTLVAGNHFLPDI-DPADLAYKALAVNLSDLAAMG--ADPAWL-TLALTLPD--V----------------DEAWLESFSNSLFDLLNYYDMQLI-GGDTTR------GP-LSMTLGIHGFVPMGR----ALTRSGAKPGDWIYVTG----TPGDSAAGLAILQNRLQV---------------ADAKDADYLIKRHLRPSP-RILQGQ-----A-----LRD-LANSAIDLSD-GLISDLGHIVKASD-CGARIDLALLPFSDAL-SRHVEPE-------------Q-------------ALRWALSGGEDYELCFTVPEL-NRGALDVALGHL------GVPFTCIGQMTADIEGL--CFIRDGEPVTLDW----KGYDHFATP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ThiL_Mariprofundus_ferrooxydans ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGEFDL-------------------IDRCFA------GRGGQPRTFTRLGIG----DDASVH---------------------------------QPAAGMELVV-----------------------------STDTSLAGVHWPTDL-PLAVAADRAVCAALSDLAAMG--AEALCC-WLN--VMA--E----------------DAGAVAQMGDGATAALARFDVELV-GGDTTR------SSCNALAVTVAGQLPAGS----AMRRSGAQAGDNIWLCG----CVGFHASGLKQWINDCK---------------------DGSFVEYFTGVVP-MLKQGV-----R-----LREQGVQCCMDISD-GLLQDATHLACASD-VGMEIELSLLPDWPQL-VDEIGEA-------------Q-------------ALQNAAHGGEDYALLFTAPAS-MRFTDACMIGRCREL--PGVSLMLGGQP-----------------VSVEK----GGYDHFQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ThiL_Methanocaldococcus_jannaschii ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDEMKV-------------------IEIIKK-------TLKFSNENIVKGID----DDCAII---------------------------------KIDENFYLVA-----------------------------TTDMMVKKAHIPSIL-SPYEIGGRILTANVSDIASMG--AKPLAF-LVSISLSKEEA----------------NEKFIKELYSGLDDFSKLYDCPVV-GGDTNR------GDELILSGTAFGITDNP-------IYRRGKVGDDICVTN----DLGRVYCALTLYYMLKENKI-------SYKEFERLCQKYPKIIEKLRKPIA-RIKEGL-----L-----MNK-LINGCCDISD-GLGKEITYFKNFEI-YSDRIFK---LIPEDV-IEFCDAF----NL-------N-------------PIKVALNSGEEFELLFTTSKF-NKVKDSLKG---------YSKIYKIGKIIEDGQFI--------DGEEFYG----GGYIHKW---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ThiL_Methanococcus_vannielii ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNEFDI-------------------INI-IS-------KNISYKNGVERGIG----DDCAVF---------------------------------KLEN-QHLVI-----------------------------TTDMMFRSTHFPEIL-TPFQIGMRIVTANVSDIAAMC--AKPLGM-VISMGFDKP------------------DLKFIDEMSKGMNFISKEYGCPIV-GGDTNK------SKELTLSGTAFGITNNP-------IYRGGNLGNEICITG----TIGRVFCALKILEMSKNGII-------DKLKFEKLIEEFPEIIKKLSEPKA-RVLEGI-----S-----LNN-VVTSCSDISD-GLSKDLNHVGFFEI-YSKELLK---AVPKDV-VEFSEKF----DI-------N-------------LIDIALNSGEEFELLFTVKDF-KNAKKVLKG---------INTVTKFGKVVESGKTV--------DGNNITF----EGYVHKW---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ThiL_Vibrio_shilonii -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSGEFSL-------------------IDKYFA-------HKQQQRKDVVLAQG----DDCAIV---------------------------------APPADSHIAI-----------------------------STDTLVSGTHFLADA-DPAWIAHKALASNISDLAAMG--ASPAWV-SMGISLPE--V----------------NERWLERFCNAFFSLADYYGIQLI-GGDTTK------GP-LAITLTVQGTLPQGK----ALTRSGANSGDWIYVTG----HLGDAKAGLDVILEKNIS---------------ANTELNRVLEKRHFEATP-RVLAGI-----T-----LRD-IASAAIDISD-GLISDLGHILKRSD-VGARIDVDLLPVSSEL-KQFVESD-----D-------I-------------AKQYALTSGEEYELCFTVPEA-NRGQLEIALS--------NTPFTCIGQITGTGY-L--DLHSNDQPLDWQL----GGFDHFKVSQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- other_Methanobrevibacter_smithii -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMDGVFISDF-------KNLVKAVQEFEGV---------TRKSSIDTVTSLLTE------SYN--VSGDVVIDIG----DDASAI---------------------------------DIGNNQVVLI-----------------------------AADGIWGQIMNV----NPYWAGYCSVLVNVNDIAAMG--GKPLAM-VNIMSVKHD--------------------EIYENLLAGIKDGCLKFGVPMV-GGHLHPD-----GEVDSLGVAIVGIAKKDK----LITSFGAEVGDKIIVAI----DLDGKPHEM------------------FELNWDT----TYDKDKQLVQDQI-TAVQYL-----A-----ERD-YIKSGKDISNPGILGTLEMLLETSD-KGAIVNLEDIPKNENI-S----------------------------------WENWLKSYPGSGFIFTANEE-N-CEFIKKYL---KD--YSIEANVVGEVTGECSLY----LVNGDGEKLEVFNQKTNPVFKSKKE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- other_Methanococcus_maripaludis ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGDFMDL-------SKLADELRNFEGV---------TRKKEIKNVVNNFNF------QED--YEFDIVVDFG----DDAAII---------------------------------GIDDENAVLL-----------------------------AADGIWGKLLET----DPFWAGYCAVLVNANDIAAMG--GRSIGM-TNIIGIKDC--------------------DKGRDLLKGLKEGVSKFGIPVV-GGHTHPD-----AQCNVLDISITGLVKRDN----VLRSDAAKTGDKIVFAY----DLDGKIHET------------------FNLNWDT----TSMKSKKYVRDQL-KVLEII-----G-----EEH-LANSCKDISNPGGLGTLGMLLEVSK-KGAMVDVSKIPVPEDV-S----------------------------------LNHWLKMYPGSGFVFTAPEN-K-TKDLIERL---EF--TGIASAVCGEVKNDRKFM----ITDGNEKTVFFDFEKEY-ICGC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- other_Methanopyrus_kandleri --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNL-------RELARELRSFEGV---------TRKHPVKTVVEGLLE------PLDVTFEGEVIADVG----EDAAAV---------------------------------KVGD-DILLI-----------------------------AADGIWGKLIDR----DPWWAGYCAVLVNVNDVLAMG--GRPVGL-VNVLSTSDV--------------------DVCREILEGMREGAWKFSTPVL-GGHTHPD-----TPYTAVDAAIVGVTDEEH----LVLSSTAEEGDLIVFVI----DLNGRPYPE------------------YPLNWDT----TTMKDPDYLRRQM-EAV--V-----E-----ASK-LVKAGKDVSNPGLVGTLAMMLEASGCLGAEVWLDSIPKPEDV-D----------------------------------MVTWLKMYPGMGFVYAVDSE-RDVRAIRRVL---SD--ARLEVSVIGEVTEDGVVK----VSEGDESARVFDFREDR-ILGVSPR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- root --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCGCK-----------EKLLK-LG--------------------------------------------VVGGIG----DDAAVI---------------------------------KIGDGLSLVS-----------------------------TTD-----FFFP--V-DPYDQGRIAVANAVNDLAAMG--AKPLAL-LDVLALPE---------------------EVLEEILKGIREGAKEAGVPLV-GGHTVV------GPWPILGGTVVGVVDREK----PITYSGAKPGDVIILTG----PLGIHGAGLALLAL-E-E-------------FETVEEADPEATKIMVRPNL-EAAK---------------D-GVNAMTDITGGGLLGHLKELAEASG-VGIEI--DKLPVIEEV-SEFA----------------N-------------PLEGALAGT-GGLLIFVAPEA-DEVLDILKK---------GL-AAVIGEVTGKGGG-----VP----------------I------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ; END;