#NEXUS
[!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file.


Generated on September 19, 2025; 0:33 GMT

TreeBASE (cc) 1994-2008

Study reference:
Lian T., Guo W., Chen M., Li J., Liang Q., Liu F., Meng H., Xu B., Chen J., Zhang
C., & Jiang L. 2015. Genome-wide identification and transcriptional analysis of
folate metabolism-related genes in maize kernels. BMC Plant Biology, .

TreeBASE Study URI:  http://purl.org/phylo/treebase/phylows/study/TB2:S17972]

BEGIN TAXA;
        TITLE  Taxa;
        DIMENSIONS NTAX=18;
        TAXLABELS
            Arabidopsis_thaliana_5FCL
            Arabidopsis_thaliana_5FCLL
            Escherichia_coli_5FCL
            Homo_sapiens_MTHFS
            Mus_musculus_MTHFS
            Mus_musculus_MTHSD
            Oryza_sativa_5FCL
            Oryza_sativa_5FCLL
            Rattus_norvegicus_MTHFD
            Rattus_norvegicus_MTHFS
            Saccharomyces_cerevisiae_FTHC
            Setaria_italica_5FCL
            Setaria_italica_5FCLL
            'Setaria italica 5FCLL-2'
            Sorghum_bicolor_5FCL
            Sorghum_bicolor_5FCLL
            Zea_mays_5FCL
            Zea_mays_5FCLL
            ;
END;

BEGIN CHARACTERS;
[! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M32435]

	TITLE 'Folate metabolism-related genes in maize 5-FCL';
	LINK TAXA = Taxa;
	DIMENSIONS NCHAR=374;
	FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -;

MATRIX
[                                         10        20        30        40        50        60        70        80        90        100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340       350       360       370    ]
[                                          .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .         .    ]
Arabidopsis_thaliana_5FCL         MIGARVFCITTTALRRSPIFFFPKIPTRPVFRLSPATRPIVAMSTTSKNQEELDSIFKQKRVVRSTVRKSLKAMDPSLRTQQDEAIQKTVLEAPWFKSCKGLCAYISCKSLNEVDTSKILSEILQHPDSNTQKKLYVPWVEDKNSNMRMLHISHMEDLVANSMNILEPAPVDAQGNDREDVLQADEPIDLFILPGLAFDRCGRRLGRGGGYYDTFLKRYQDRAKEKGWRYPLMVALSYSPQILEDGSIPVTPNDVLIDALVTPSGVVPITPRATESM-------------------------------------------------------------------------------------------------
Arabidopsis_thaliana_5FCLL        MIRLSPGFAINPRFRSDSFVNSQKPPFLSVQIGSQRRNLSRIGSENGDGVAFDAVAYEADRLSLDAAAMEDMAETAKKELESDPDSDPKAWKWVIRKKMWDLMEARNYAMSPRPVHHRIPNFVGASAAARKLAELDAFRMAMVVKVNPDSPQKQIRFLTLSGEKKLLTPQPRLRTGFFSVLESDLLKPETIMEACTSVGVAKYGRAIGLDEKIKVDLIVIGSVAVNPQTGARLGKGEGFAELEYGMLRYMGAIDDSTPVVTTVHDCQLVDDIPLEKLAIHDVPVDIICTPTRVIFTNTPIPKPQGIYWDKLSPEKLRQIRILRELKNRLEKKTGRKLPTGPSEKLPPTAERKRR--------------------
Escherichia_coli_5FCL             MIRQRRRALTPEQQQEMGQQAATRMMTYPPVVMAHTVAVFLSFDGELDTQPLIEQLWRAGKRVYLPVLHPFSAGNLLFLNYHPQSELVMNRLKIHEPKLDVRDVLPLSRLDVLITPLVAFDEYGQRLGMGGGFYDRTLQNWQHYKTQPVGYAHDCQLVEKLPVEEWDIPLPAVVTPSKVWEW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Homo_sapiens_MTHFS                MAAAAVSSAKRSLRGELKQRLRAMSAEERLRQSRVLSQKVIAHSEYQKSKRISIFLSMQDEIETEEIIKDIFQRGKICFIPRYRFQSNHMDMVRIESPEEISLLPKTSWNIPQPGEGDVREEALSTGGLDLIFMPGLGFDKHGNRLGRGKGYYDAYLKRCLQHQEVKPYTLALAFKEQICLQVPVNENDMKVDEVLYEDSSTA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Mus_musculus_MTHFS                MAAVTVNSAKRGLRAELKQRLRALSAEERLRQSLLLTQKVIAHNQYQNSKRISIFLSMQDEVETEVIIKDIFKQGKICFIPRYQFQSNHMDMVRLTSSEEIALLPKTSWNIHQPGEGDVREEALSTGGLDLIFLPGLGFDKDGNRLGRGKGYYDTYLKRCVQHQEVKPYTMALAFKEQICPQIPVDEHDMKVDEVLYEDSPAS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Mus_musculus_MTHSD                METQEGVSKQSIRERIWDYMESHDIADFPRPVHHRIPNFKGAAQAAGHLPHLQAFHVARTIKVNPDAPQRNARFLVLESKKTLLVPTPRLRTGLFNKITPPPGATKDILRKCATSQGVRNFSVPVGLDSSVLVDLVVVGSVAVSEKGWRIGKGEGYADLEYAMMVSMGAVHKGTPVVTIVHDCQVVDIPEALVEDHDLTVDYILTPTRVITTGCARPKPTGIMWSKVSCEMLTKIPVLRNLREREKQAGKDVTLRDEPGSQQPAPGPIRRPQDRPQTGSRGGSRSPLQGADTQLAATVCVGNLPFTTRVRELKRVLQELGVVPLRLTWQGPQHRAVLHYTDSAAAQQAASLLQGLRLGANALRVSLGQQRDM--
Oryza_sativa_5FCL                 MIKNGAASLMVRLLHLPRAASAPTYPRRRHHLALLPSLRLRVPAPAAAAAMSSAAAAQEVADQKRALRSEVRRALRALTPEQRASEDQAIQNAILNSSWFKESKRLCAYISCAQLREVDTSKVLSEVLSPNSEHGHAKDLYVPRVEDKNRNMRMLKITTMDDLVKNSMNILEPSPLDASGNAREEVLSTSSPVDLFLLPGQAFDRTGRRLGRGGGYYDTFLMRYQELAKEKGWDQPLLVALSYSVQILEEGIIPVNSTDVPIDALVSSSGIIPISPAALARI--------------------------------------------------------------------------------------------
Oryza_sativa_5FCLL                MPLLPASPPPLSLSRSLAAAAAASRRGRAVTCAAARGAASSSSASFDAAGFEAERLRLDAEARAGMASAAAVAGAEAADPKAWKWAIRKRVWDALEAEGVARDPRPVHHRIPNFDGAAAAADSLGRLDVFQDAQCVKVNPDSPQKQVRFLTLSGDKKLLTPQPRLRTGFFSVLESHMIPIGCIPEACTSVGAAKYGRPIGLDEKIKVDLIVIGSVAVDPSTGARLGKGEGFAELEYGMLRYMGSISDSTMIVTTVHDKQLVNDIPVEKLLVHDVPVDIICTPTQVIFTNTTIAKPQGIYWEKLSPEKLGQIRILQELKRRIESETGTTLPCGPSEKLPPTAQRRRRKRRR------------------------
Rattus_norvegicus_MTHFD           QGASRAAEHFPHLHAFSAARTIKVNPDAPQRNARFLVLESRKTLLVPTPRLRTGLFNKIIPPPGATKDILRKCATSQGVRNFSVPVGLDSNVLVDLVVVGSVAVSEKGWRIGKGEGYADLEYAMMVSMGAVHEGTLVVTIVHDCQVVDIPEALLEDHDLTVDYILTPTRVIATGCARPKPTGILWSKVSCEMLTKIPVLRSLREREKRAGTDVTLQAEPGNTQQPAPSTVRRPQDRPQSRFRGRSHSSLEGTDTHLAATVCLGNLPYSARVRELKRALQELGAVPLRLTWQGPQHRAILHYTDSAAAQQAASLLQGLRLGDNALRVSLGQQRDT----------------------------------------
Rattus_norvegicus_MTHFS           MAAVTVNSAKRGLRAELKQRLRALGAEERLRQSHLLTQKVIAHSQYQNSKRISIFLSMQDEIETEEIIKDIFKQGKICFIPRYQFHSNHMDMVRLTAPEEVALLPKTSWNIHQPGEGDVREEALSTGGLDLIFLPGLGFDKDGNRLGRGKGYYDTYLKRCVQHQKVKPYTLALAFREQICPQIPVDEHDMKVDEVLYEDSPTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Saccharomyces_cerevisiae_FTHC     MATKQLLRRQIKRVINALDYDIIAAESHTISQAVRSLIASANSRRVACYMSMDKGEVTTGEIIKNLFQDGQEVFLPRCTHTSESKHFKLREDHHPHLIFHRMSSLKMVRDLKPQGPYQLKEPEPHIEESDILDVVLVPGVAFDIKTGARMGHGAGYYDDFFQRYKILHEGQKPLLVGLCLMEQVASPIPLEKHDYSMDCIVCGDGSIHWFQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Setaria_italica_5FCL              MIKNAVASLMVRLHHLPLPRAAPASTYRHHHHHALHLPPPASVPLRPAAGAAMSTTAEQAVADQKRALRTEVRRALKALSPDQRASEDLAIQTTILDSSWFKASKRLCAYISCQQLREVDTSKILAECLPSSPGQEELAKDLYVPRVEDKNRNMRMLKITTMDDLVKNSMNILEPSPVDASGNDREDVLSSSSPIDLFLLPGQAFDRTGRRLGRGGGYYDTFLLKYQELAKEKGWNQPLLVALSYSVQIMEEGIIPVNSTDVPIDALVSSSGVIPISPTALERM------------------------------------------------------------------------------------------
Setaria_italica_5FCLL             MPLLFPKAAPPLPLCLAARASRRARLAVASTAGGSSSSSSSASASFDAAAFEAERLRLDAAARDGMASAAAVAEADPRAWKWAIRKRVWDALEAEGIARDPRPVHHRIPNFDGAPAAADALGRLDVFQNSQWVKVNPDSPQKQVRFLTLSGDKKLLTPQPRLRTGFFSVLDSQMIPIGCVPEACTSVGAAKYGKPIGLDERIKVDLIVIGSVAVDPSSGARLGKGEGFAELEYGMLRYMGAIDDSTMIVTTVHDKQLVDDIPVEKLLIHDVPVDIICTPTQVIFTKTTIPKPQGIYWEKLSPEKLGQIRILRELKKRIEQETGTILPCGPSEKLPPTAQRRRRVRQQRRR------------------------
'Setaria italica 5FCLL-2'         MLRYMGATDDSTVILTTVHDSQLVDDIPVEKLQIHDVPVDIICTPTQVIFTNTTIPKPQGIYWEKLSPEKLGQIRVLRELKARIEQEMGTKLPCGPPVKLPQASKQEGLECKREGR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Sorghum_bicolor_5FCL              MIKNAVATLMVRLHHLPLPRAAPAPTYRCRRHITLPLPRPQASAAAMSTATEQAVADQKRALRADVRRALKALSPDQRASEDLAIQTTIMDSSWFKASKRLCAYISCKQLREVDTSKILEECLSSNPGQEELAKDLYVPRVEDKNRNMRMLKITTMDDLVKNSMNILEPSPVDATGKDREDVLSSSSPVDLLLLPGQAFDRTGRRLGRGGGYYDTFLMKYQELAKEKGWNQPLLVALSYSVQIMDEGVIPVNSTDVPIDALVSSSGVIPISAAALQRMR-----------------------------------------------------------------------------------------------
Sorghum_bicolor_5FCLL             MPLVFPATPPLPLCPAARRATAAVASAARSSSSSSSSASFDAAAFEAERLRLDAAARAGMESTARAAAAEANPRAWKWAIRKRVWDALEAEGVARDPRPVHHRIPNFDGAPAAADALGRLDIFQNSQCVKVNPDTPQKQVRFLTLSGDKKLLTPQPRLRTGFFSVMDSQMIPVGCIPEACTSVGAAKYGRPIGLDESLKVDLIVIGSVAVDPSSGARLGKGEGFAELEYGMLRYMGAIDDSTMIVTTVHDKQLVDDIPVEKLLVHDVPVDVICTPTQVIFTKTTIPKPQGIYWEKLSPEKLGQIRILRELKQRIEQETGTILPCGPSEKLPPTAQRRQRWRRRR------------------------------
Zea_mays_5FCL                     MIKNTVATLMVRLHHLPLPRAAPAPTYRCGRHLALAPPLPRLRASAAVMSTAAEQTIADQKRTLRAEVRRALKALSADQRASEDLAIQTTILDSSWFKASKRLCAYISCQQLREVDTSKILAECLPSNPGQEELAKDLYVPRVEDKNRNMRMLKITTMDDLVKNSMNILEPSPVDATGNNREDVLSSLSPVDLFLLPGQAFDRTGRRLGRGGGYYDTFLLKYQELAKEKGWNQPLLVALSYSVQIMDEGIIPVNSTDVPIDALVSSSGVIPISAAALQRMQ---------------------------------------------------------------------------------------------
Zea_mays_5FCLL                    MDSQMIPVGCIPEACTSVGAAKYGRPIGLDESLKVDLIVIGSVAVDPSSGARLGKGEGFAELEYGMLRYMGAIDDSTMIVTTVHDKQLVDDIPVEKLLVHDVPVDIICTPTQVIFTKTTIPKPQGIYWEKLSPEKLGQIRILRELKQRIEQETGTMLPCGPSEKLPPTAQRKQRWQRRR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
;
END;