#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 19, 2025; 0:33 GMT TreeBASE (cc) 1994-2008 Study reference: Lian T., Guo W., Chen M., Li J., Liang Q., Liu F., Meng H., Xu B., Chen J., Zhang C., & Jiang L. 2015. Genome-wide identification and transcriptional analysis of folate metabolism-related genes in maize kernels. BMC Plant Biology, . TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S17972] BEGIN TAXA; TITLE Taxa; DIMENSIONS NTAX=23; TAXLABELS Arabidopsis_thaliana_FOLD1 Arabidopsis_thaliana_FOLD2 Arabidopsis_thaliana_FOLD3 Arabidopsis_thaliana_FOLD4 Escherichia_coli_FOLD__ Homo_sapiens_MTD2L Homo_sapiens_MTDC Mus_musculus_MTD2L Mus_musculus_MTDC Oryza_sativa_FOLD1 Oryza_sativa_FOLD2 Oryza_sativa_FOLD3 Rattus_norvegicus_MTD2L Rattus_norvegicus_MTDC Setaria_italica_FOLD1 Setaria_italica_FOLD2 Setaria_italica_FOLD3 Sorghum_bicolor_FOLD1 Sorghum_bicolor_FOLD2 Sorghum_bicolor_FOLD3 Zea_mays_FOLD1 Zea_mays_FOLD2 Zea_mays_FOLD3 ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M32439] TITLE 'Folate metabolism-related genes in maize DHC'; LINK TAXA = Taxa; DIMENSIONS NCHAR=408; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 ] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] Arabidopsis_thaliana_FOLD1 MLMIARKALASAHTKAFRLATRDVHCFSSILVSPPLVSLDLPENWIPYSDPPPPVSFETEQKTVVIDGNVIAEEIRTKIISEVGKMKKAVGKVPGLAVVLVGEQRDSQTYVRNKIKACEETGIKSVLAELPEDCTEGQIISVLRKFNEDTSIHGILVQLPLPQHLNESKILNMVRLEKDVDGFHPLNVGNLAMRGREPLFVSCTPKGCVELLIRTGVEIAGKNAVVIGRSNIVGLPMSLLLQRHDATVSTVHAFTKDPEHITRKADIVIAAAGIPNLVRGSWLKPGAVVIDVGTTPVEDSSCEFGYRLVGDVCYEEALGVASAITPVPGGVGPMTITMLLCNTLEAAKRIFL-------------------------------------------------------- Arabidopsis_thaliana_FOLD2 MASSSDHTAKIIDGKAIAHTIRSEIAEEVRGLSEKHGKVPGLAVVIVGSRKDSQTYVNTKRKACAEVGIKSFDVGLPEEVSEADLISKVHELNSNPDVHGILVQLPLPKHINEEHILGAISIDKDVDGFHPLNIGKLAMKGREPLFLPCTPKGCLELLARSGVKIKGQRAVVVGRSNIVGLPVSLLLLKADATVTTVHSHTKDPEAIIREADIVIAACGQAHMIKGNWIKPGAAVIDVGTNAVSDPSKKSGYRLVGDVDFAEASKVAGFITPVPGGVGPMTVAMLLRNTVDGAKRVFGE------------------------------------------------------------------------------------------------------------- Arabidopsis_thaliana_FOLD3 MFTDCSSSTTSRLIHLYNRNGVFLPRPSVSQFSLRTTASTWRCTLSIRSSSSPSAIVIDGKAEAKKIRDDIKIEVSRMKESIGVVPAEDSSEEEVLKYVSGFNDDPSVHGVLVQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRLAMRGREPLFVPCTPKGCIELLHRYNIEFKGKRAVVIGRSNIVGMPAALLLQKEDATVSIIHSRTMNPEELTRQADILISAVGKPNMVRGSWIKPGAVLIDVGIKPVEDPSAAGGERLVGDICYVEASKIASAITPVPGDVGPMTIAMLLSNTLTSAKRIHNFQ-------------------------------------------------------------------------------------------------- Arabidopsis_thaliana_FOLD4 MASMMFTDCSSTTTSRLIHLNRSSGTFLLRQCVGQLRLQTTASGRGCCIRSSSSPISSISADTKSEGGAIVIDGKAVAKKIRDEITIEVSRMKESIGVIPGLAVILVGDRKDSATYVRNKKKACDSVGIKSFEVRLAEDSSEEEVLKSVSGFNDDPSVHGILVQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRLAMRGREPLFVPCTPKGCIELLHRYNIEIKGKRAVVIGRSNIVGMPAALLLQREDATVSIIHSRTKNPEEITREADIIISAVGQPNMVRGSWIKPGAVLIDVGINPVEDPSAARGYRLVGDICYEEASKVASAITPVPGGVGPMTIAMLLSNTLTSAKRIHNFQ------------------------------------------------ Escherichia_coli_FOLD__ MAAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVQLPLPAGIDNVKVLERIHPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGINRLENGKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQACVEYHDPQDE------------------------------------------------------------------------------------------------------------------------ Homo_sapiens_MTD2L MTVPVRGFSLLRGRLGRAPALGRSTAPSVRAPGEPGSAFRGFRSSGVRHEAIIISGTEMAKHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYVRNKIRAASAVGICSELILKPKDVSQEELLDVTDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRLCLDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDATVTIAHRYTPKEQLKIHTQLADIIIVAAGIPKLITSDMVKEGAAVIDVGINYVHDPVTGKTKLVGDVDFEAVKKKAGFITPVPGGVGPMTVAMLLKNTLLAAKKIIY------------------------------------------------------------- Homo_sapiens_MTDC MAATSLMSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN---------------------------------------------------------- Mus_musculus_MTD2L MATRARGFSLLRGRLGRGPVRAPGVAERAWRGFGSSGRRHEAVIISGTNMAKQIQKEIQQGVESWIALGNRRPHLSIILVGDNPASHTYVRNKIKAASAVGICSELIIKPKNVSQEELLDITDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRLCLDQHSLIPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDATVTIAHRYTPREQLKAHTQLADIIIVAAGIPRLITADMVREGAAVIDVGINYIQDPVTGKTKLVGDVDFEAVKKKASFITPVPGGVGPMTVAMLLKNTLLAAKNIAY---------------------------------------------------------------------- Mus_musculus_MTDC MASVSLLSALAVRLLRPTHGCHPRLQPFHLAAVRNEAVVISGRKLAQQIKQEVQQEVEEWVASGNKRPHLSVILVGDNPASHSYVLNKTRAAAEVGINSETIVKPASVSEEELLNSIRKLNNDENVDGLLVQLPLPEHIDERKVCNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVQDPVTAKPKLVGDVDFEGVKKKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRPEELEVFKSKQRGVATN---------------------------------------------------------- Oryza_sativa_FOLD1 MGGAAAAAAVALLAATRRRPAAGPLAFLLPRAARAGLHEAAAPAAEEEKGRTRRRRRRRSSSSRLLGPDIPDTWDSPPRAAARPSPPSGAGVDYDSTATIIDGKSVAEDIRFQIAEEVRQMKNAVGHVPGLAVVLVGDRRDSESYVRYKIKGCEEVGIKSLLAELPGNCTEDVVVDSVSRFNEDPSVHGILVQLPLPQHMDEERILSAISLEKDVDGFHPLNVGNLALRSRKPLFVPCAAKACLELLLQSGIELMGKHVTVIGRSKVVGLPTSLLLQRHHATVSIIHAFTTNPEEITRQSDIVISAAGVANLVRGSWLKKGAVVIDVGTNPIEDPTSDYGYRLTGDVCFEEAVKLASAITPVPGGVGPVTIAMLLANTLDSAKLAYGLATESPEL------------- Oryza_sativa_FOLD2 MAQIIDGKGVAADIRREVAADVAALSSAHNLVPGLAVVIVGSRKDSQTYVQMKRKACAEVGIRSVDVDLAEDISEAALVAEVHRLNADPAVHGILVQLPLPKHINEEKILNEISLEKDVDGFHPLNIGKLAMKGRDPLFLPCTPKVPGLAVVIVGSRKDSQTYVQMKRKACAEVGIRSVDVDLAEDISEAALVAEVHRLNADPAVHGILVQLPLPKHINEEKILNEISLEKDVDGFHPLNIGKLAMKGRDPLFLPCTPKGCMELLTRSGVTINGKRAVVVGRSNIVGLPVSLLLLKADATVSIVHSRTPNPESIVREADIVIAAAGQAMMIKGDWIKPGAAVIDVGTNSISDPTRKSGYRLVGDVDFAEVSKVAGHLTPVPGGVGPMTVAMLLKNTVDGAKRGIVQ-- Oryza_sativa_FOLD3 MASSILSDCSSSATSRLLPLRRALLAPPCRFRPATVAAPPRRPLAIAAPQLPLLPRARGTASASAAAAAAASSTDSDACAKIIDGKLVAKQIREEIAVEIAKMKDAIGVVPGLAVILVGSRKDSQTYVRNKKKACEAVGIKSYEVNLPEDSSEDEVLKHIATFNSDPSVHGILVQLPLPHHMNDENILNAVSIEKDVDGFHPLNIGRLAMQGRDPFFVPCTPKGCMELLHRYGVEIKGKRAVVIGRSNIVGMPAALLLQKANATVSIVHSNTKKPEEITRQADIVIAAVGVANLVRGSWIKPGAAIIDVGINPVDDPESPRGYRLVGDVCYEEASKIAGLITPVPGGVGPMTIAMLLSNTLESAKRIHKFK------------------------------------- Rattus_norvegicus_MTD2L MATRARGLSLLRGRLGRGPARAPGVAERAWRGFGSSSRRHEAVIISGTEMAKQIRRELQQGVESWLALGNRRPHLSIILVGDNPASHTYVRNKIRAASAVGICSELIVKPKNVSQEELLDITDQLNMDPRVSGILVQLPLPDHVDERTICNGIAPEKDVDGFHIINIGRLCLDQHSLIPATASAVWEIIKRAGIETFGKNVVVAGRSKNVGMPIAMLLHTDGEHERPGGDATVTIAHRHTPREQLKAHTQLAEIIIVAAGIPGLITADMVREGATVIDVGINYVQDPVTGKTKLVGDVDFEAVKKKASFITPVPGGVGPMTVAMLLKNTLLAAKNITY---------------------------------------------------------------------- Rattus_norvegicus_MTDC MVSVSLSALAVRLLRPTHGCHSRLQSFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGDNPASHSYVLNKTRAAAEVGINSETIVKPASVSEEELLNSIRTLNDDENVDGLLVQLPLPEHIDERKICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEILKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRHTPKEQLKKHTILADIVISAAGIPNLITADMIKEGATVIDVGINRVQDPVTAKPKLVGDVDFEGVKKKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRPEELEVLKSTQRGVATN----------------------------------------------------------- Setaria_italica_FOLD1 MGGAAVAVLAAAATRHNRAPLASLIYRVARGLHDASAAAAAAEEEKAGTQSRRRRRRSSSSLLLGPDFPDTWDTPPRAASRTPPPRDTGADYDCTATIIDGKSIAEDIRLHIAEEVRQMKSVVGHVPGLAVVLVGNRRDSESYVRYKTKGCEEVGIKSLLAKLPGNCTEDQVMDSVSRFNEDPSVHGILVQLPLPQHMDEERILSAISLEKDVDGFHPLNVGNLALRSRKPLFLPCAAKACIELLLQSGIEIMGKHVTVIGRSKVVGLPTSLLLQRHHATVSIIHAFTTNPEAITRESDIVISAAGVANLVRGSWLKQGAVVIDVGTNPIEDPTSDYGYRLTGDVCFEEAVKVASAITPVPGGVGPVTIAMLLSNTLDSAKRVYGLSD-------------------- Setaria_italica_FOLD2 MAQIIDGKAIAADIRREVAAEVATLSSAHNVVPGLAVVIVGSRKDSQTYVNMKRKACAEVGIRSVDVDLPEDISELALVAEVHRLNADPAVHGILVQLPLPKHINEEKILSEISIEKDVDGFHPLNIGKLAMKGREPLFVPCTPKGCMELLSRSGVTVKGKRAVVVGRSNIVGLPVSLLLLKADATVSIVHSRTSNPESIVREADIVIAAAGQAMMIKGDWIKPGAAVIDVGTNSVDDPTRKSGYRLVGDVDFAEVSKVAGYLTPVPGGVGPMTVAMLLKNTVDGAKRGIVE-------------------------------------------------------------------------------------------------------------------- Setaria_italica_FOLD3 MASSILSDCSSARLLPLRRALLPQRVPRIRPCPALASSRRLFAAARPQLLPRPPRMDSVPAAAASSAESATVAADASAKVIDGKLVAKQVREEIAVEVTKMKDVIGIVPGLAVILVGSRKDSQTYVRNKKKACEAVGIKSYEVNLPEDSSEEEVIQHIASFNSDPSVHGILVQLPLPRHMNDENVLNAVSIEKDVDGFHPLNIGRLAMQGRDPFFVPCTPKGCMELLHRYGVEIKGKRAVVIGRSNIVGMPAALLLQKANATVSIVHSQTKNPEEITRQADIIIAAVGVANLVRGNWIKPGAAIIDVGINPVDDPESPRGYRLVGDVCYEEASKVAGAITPVPGGVGPMTIAMLLSNTLESAKRIHNFK--------------------------------------- Sorghum_bicolor_FOLD1 MGGAAVAVLAAATARRKSGPFVSLFSRAARRLHDAAETAAAEEDKAGTQSRRRRRSSSSLLLGPDFLDTWDPISRDTTPQAPPRCAQADYDRTATIIDGKSIAEDIRFHIAEEVCQMKRSVGHVPGLAVVLVGDRRDSESYVRYKVKGCEEVGIKSLLAKLPGNCSEDEVMDSVSRFNEDPSVHGILVQLPLPEFMDEERILSTISLEKDVDGFHPLNVGNLALRSRNPLFVPCAAKACIELLLQSGIELMGKHVAVIGRSKVVGLPTSLLLQRHHATVSVIHAFTTNPEAITRESDIVISAAGVANLVRGSWLKQGAVVIDVGTNPIEDPTSDYGYRLTGDVCFEEAVNVASAITPVPGGVGPVTIAMLLGNTLDSAKRVYGQSD---------------------- Sorghum_bicolor_FOLD2 MAQIIDGKAIAADIRREVAADVAALSSAHGLVPGLAVVIVGSRKDSQTYVNMKRKACAEVGICSIDVDLPEDISEPALVAEVHRLNADPAVHGILVQLPLPKHINEEKILNEISIEKDVDGFHPLNIGKLAMKGREPLFQPCTPKGCMELLSRSGVTVKGKRAVVVGRSNIVGLPVSLLLLKEDATVSIVHSRTPDPESIVREADIVIAAAGQAMMIKGDWIKPGAAVIDVGTNSVDDPTRKSGYRLVGDVDFAAVSKVAGYLTPVPGGVGPMTVAMLLKNTVDGAKRGIVE-------------------------------------------------------------------------------------------------------------------- Sorghum_bicolor_FOLD3 MASSILSDCSSARLLPLRRALLPPAPGLRPCPALAHPRRLLVAARPQLLPRPRRMDSVPAATASSADSATVSADALAKVIDGKLVAKQVREEIAVEVTRMKDAIGIVPGLAVILVGSRKDSQTYVRNKKKACEAVGIKSYEVNLPEDSSEEEVIKHIASFNSDPSVHGILVQLPLPRHMNDENILNAVSIEKDVDGFHPLNIGRLAMQGRDPFFVPCTPKGCMELLHRYGVEIKGKRAVVIGRSNIVGMPAALLLQKANATVSIVHSQTKNPEEITRQADIVIAAVGVANLVRGNWIKPGAAIIDVGINPVDDPESPRGYRLVGDVCYEEASKVAGAITPVPGGVGPMTIAMLLSNTLESAKRIHKFK---------------------------------------- Zea_mays_FOLD1 MGGAAAAVLAVAAARRKSGPFVSLFSRAARRLHDAVETAAAEEDMAGTRSPRRRRRSSSSLLLGPEFPDTWDPSSRDTTPQSPPRCAQADYDRTASIIDGKSIAEDMRLHIAEEVCQMKCSVGHVPGLAVVLVGDRRDSESYVRYKTKGCEEVGIKSLLAKLPGNCSEDEVMDSVSRFNEDPSVHGILVQLPLPEFMDEEKILSIISLNKDVDGFHPLNVGNLALRSRNPLFVPCAAKACIELLLQSGIELMGKHVSVIGRSKVVGLPTSLLLQRHHATVSVIHAFTTNPEAITRESDIVISAAGVANLVRGSWLKQGAVVIDVGTNPIEDPTSDYGYRLTGDVCFEEAVNVASAITPVPGGVGPVTIAMLLGNTLDSAKRVYGLSD--------------------- Zea_mays_FOLD2 MAQIIDGKAIAADVRREVAADVAALSSAHGLVPGLAVVIVGSRKDSQTYVNMKRKACAEVGICSIDVDLPEDISETALVAEVHRLNADPAVHGILVQLPLPKHINEEKILSEISIEKDVDGFHPLNIGKLAMKGREPLFVPCTPKGCMELLSRSGVTVKGKRAVVVGRSNIVGLPVSLLLLKADATVSVVHSRTPDPESIVREADIVIAAAGQAMMVCMQLCRQILTVRCSILQPVQRCSLSPSMCSFLARQIKGDWIKPGAAVIDVGTNSVDDPTRKSGYRLVGDVDFAAASKVAGYLTPVPGGVGPMTVAMLLKNTVDGAKRGIVE-------------------------------------------------------------------------------- Zea_mays_FOLD3 MASSILSDCSSARLLPLRRSLLPPRAPRLRSCPALATPRRLLVAARPQLLPRPRHMDSVPAATASSADSATVSADAPAKLIDGKLVAKQVREEIAVQVTRMKDVIGIVPGLAVILVGSRKDSQTYVRNKKKACEAVGIKSYEVNLPEDSSEEEVIKHIASFNSDPSVHGILVQLPLPRHMNDENILNAVSIEKDVDGFHPLNIGRLAMQGRDPFFVPCTPKGCMELLHRHGVEIKGKRAVVIGRSNIVGTPAALLLQKANATVSIVHSQTKNPEQITRQADIVIAAVGVANLVRGDWIKPGATIIDVGINPVDDPESPRGYRLVGDVCYEEASKVAGAITPVPGGVGPMTIAMLLSNTLESARRIHGFK--------------------------------------- ; END;