#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 18, 2025; 21:24 GMT TreeBASE (cc) 1994-2008 Study reference: Moya A., Sakamaki K., Mason B.M., Huisman L., Foret S., Weiss Y., Bull T.E., Tomii K., Imai K., Hayward D.C., Ball E.E., & Miller D.J. 2015. Functional conservation of the apoptotic machinery from coral to man: the diverse and complex Bcl-2 and caspase repertoires of Acropora millepora. BMC Genomics, . TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S18551] BEGIN TAXA; TITLE Taxa; DIMENSIONS NTAX=103; TAXLABELS Acropora_digitifera_Adicasp1 Acropora_digitifera_Adicasp10 Acropora_digitifera_Adicasp12 Acropora_digitifera_Adicasp13 Acropora_digitifera_Adicasp15 Acropora_digitifera_Adicasp19 Acropora_digitifera_Adicasp2 Acropora_digitifera_Adicasp20 Acropora_digitifera_Adicasp21 Acropora_digitifera_Adicasp22 Acropora_digitifera_Adicasp3 Acropora_digitifera_Adicasp4 Acropora_digitifera_Adicasp5 Acropora_digitifera_Adicasp6 Acropora_digitifera_Adicasp8 Acropora_digitifera_Adicaspx Acropora_millepora_Amil12671 Acropora_millepora_Amil12676 Acropora_millepora_Amil12678 Acropora_millepora_Amil12876 Acropora_millepora_Amil18519 Acropora_millepora_Amil19957 Acropora_millepora_Amil2288 Acropora_millepora_Amil26153 Acropora_millepora_Amil779 Acropora_millepora_Amil8100 Acropora_millepora_Amil8447 Acropora_millepora_Amil8454 Acropora_millepora_Amil9566 Acropora_millepora_Amil9586 Aiptasia_pallida_Aipq3hl92 Anemonia_viridis_Aviq09y99 Canis_lupus_familiaris_Canfcasp1 Canis_lupus_familiaris_Canfcasp10 Canis_lupus_familiaris_Canfcasp12 Canis_lupus_familiaris_Canfcasp14 Canis_lupus_familiaris_Canfcasp16 Canis_lupus_familiaris_Canfcasp2 Canis_lupus_familiaris_Canfcasp3 Canis_lupus_familiaris_Canfcasp4 Canis_lupus_familiaris_Canfcasp8 Canis_lupus_familiaris_Canfcasp9 Canis_lupus_familiaris_Canfclar Fugu_rubripes_Fugcasp3 Fugu_rubripes_Fugh2sku3 Fugu_rubripes_Fugh2thl4 Fugu_rubripes_Fugh2uky4 Fugu_rubripes_Fugh2v832 Gallus_gallus_Galcasp1 Gallus_gallus_Galcasp10 Gallus_gallus_Galcasp18 Gallus_gallus_Galcasp2 Gallus_gallus_Galcasp3 Gallus_gallus_Galcasp7 Gallus_gallus_Galcasp8 Gallus_gallus_Galcasp9 Homo_sapiens_Humcasp1 Homo_sapiens_Humcasp10 Homo_sapiens_Humcasp14 Homo_sapiens_Humcasp2 Homo_sapiens_Humcasp3 Homo_sapiens_Humcasp4 Homo_sapiens_Humcasp5 Homo_sapiens_Humcasp6 Homo_sapiens_Humcasp7 Homo_sapiens_Humcasp8 Homo_sapiens_Humcasp9 Homo_sapiens_Humcaspc Homo_sapiens_Humcflar Mus_musculus_Mousecas1 Mus_musculus_Mousecas12 Mus_musculus_Mousecas14 Mus_musculus_Mousecas2 Mus_musculus_Mousecas3 Mus_musculus_Mousecas4 Mus_musculus_Mousecas6 Mus_musculus_Mousecas7 Mus_musculus_Mousecas8 Mus_musculus_Mousecas9 Mus_musculus_Mouseclar Nematostella_vectensis_Nemve201 Nematostella_vectensis_Nemve202 Nematostella_vectensis_Nemve203 Nematostella_vectensis_Nemve205 Nematostella_vectensis_Nemve206 Nematostella_vectensis_Nemve207 Nematostella_vectensis_Nemve210 Stylophora_pistillata_Stpg8xqy3 Tetraodon_nigroviridis_Tetncflar Tetraodon_nigroviridis_Tetngcasp2 Tetraodon_nigroviridis_Tetngcasp3 Tetraodon_nigroviridis_Tetngcasp6 Tetraodon_nigroviridis_Tetngcasp7 Tetraodon_nigroviridis_Tetngcasp8 Tetraodon_nigroviridis_Tetngcasp9 Xenopus_tropicalis_Xencasp1 Xenopus_tropicalis_Xencasp10 Xenopus_tropicalis_Xencasp2 Xenopus_tropicalis_Xencasp3 Xenopus_tropicalis_Xencasp6 Xenopus_tropicalis_Xencasp7 Xenopus_tropicalis_Xencasp9 Xenopus_tropicalis_Xencflar ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M35273] TITLE Metazoan_Caspase; LINK TAXA = Taxa; DIMENSIONS NCHAR=238; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 ] [ . . . . . . . . . . . . . . . . . . . . . . . ] Acropora_digitifera_Adicasp1 GYCVIINNRQFQGNEMTY-REGSERDVERLRNLFE-SLRFEVIIKRDLKRDQIEGVAQEYGG-KKHDKFVAFVLIIMSHGDEDCILGVDNKPVSVRALMREFKAEKCPSLKGKPKILIIQTCR-TEFDLADNRVDPFLLDSSLS----KSVFPPETDFLLAFATVPGYVSFRSPTFGAFFIQELVEVIEKYHGSHHLLDMLTEVTRRVIDHQNREFDPARYRVQVPAPTHTLTKLLYL Acropora_digitifera_Adicasp10 --GYVLVINNVQFPGRVNPRSGSDED-VQRLVDLFQEFGFEIRGSRDLERRDMMTLLRDTSAR-DFTRYDCFVCVILSHGAEDGIYGTDDQVITLEAITSLFRRDPCPSLQGKPKIFLIQACRGTQRDRVSTE--------SDSD----PSLPADSDFLICFASAPGHECYREGSVGSWFMCAIHKVFKEYADKEHIMDMMLRVNNEVA-----YLSP-RGLKQMPCEICMLTKKVFF Acropora_digitifera_Adicasp12 GWCLIINNVDFEHHT----RGGSDID-AKQLKELFTNLQYKVQEHRNQTAEQLKNTVLQFSKMSGHKEADSMVFCLLSHGLEGQVYGCDGELVSISDLVAMFNGYEAKDLIGKPKMIFIQACRGVEYDH-----GADLEVTDDGFLVEPETIPAEADMLVAYSTVPGYVSWSHLQKGSWFKLT------------------------------------------------------- Acropora_digitifera_Adicasp13 -LALIFNVVSYYNHMGDRP--GSKVD-AERLEKLFKGIGYKVQVHRDPPSARDFEIKLKDLLANHAIG-DSVIVAVMAHGNEGMICS-NGDIFSVNKIVCILG--NADMYLGKPKLIFIQASR-LNLSNISRNPVKSDGASLYARDSLPLGIPAHSDVLIGYDTLPGFLSYRDLRQGSWYIQSLVEVFSQYAFEEDVLRLLTFVNFNVSRKFE----TMPGFRQIPAPQSTLTKKLFF Acropora_digitifera_Adicasp15 GYCVIINNLKFQENEEAY-REGCGQDEKRLGNLFK-SLRFKVIIKRNLEKNQIERVAQEYGG-RNHDKFAAFVLIVMSHGDRDCILGVDNRTTSVGALMSEFQAERCPSLKGKPKILIIQTCR-TKFDGADNCVGPFSLDSSLS----KSVFPPEADFLLAFATVPGYVSFRSKKSGAFFIQELVEVIETYHGSHHLLDMLTEVTRRVIDHQNREFNSAAYRVQVPAPTHTLTKLFFL Acropora_digitifera_Adicasp19 GYCLIINNMSFE-DKKLN-RHCAIHDEQNLRALFENDLHFQVHIVNDLQNFQMEDICTEYSK-KDHSKFDAFVCIVMSHGTGDKIIGVKGRTIGIEQLMSKFKAKNCPSLAHKPKMFFIQACR-TQSKGDNDYDAGLTSDSTLAR--CSSILPQESDFLLGYATVPGYVAYKQSNYGSFYMQALTDIIKRHHRRYHLEEMLVEVNNSVSEKCN----------QVSAKHSTLRGKVFL Acropora_digitifera_Adicasp2 GYCVIINNRQFQGNDEAY-REGSEQDEERLTNLFE-SLRFEVIIKRDLKRDQIKGVAQEYGG-TNHDKFVAFVLIVMSHGDKDCIFGVDNDSISVRNLMKEFQAEMCPSLKGKPKILIMQTCR-TEFDQADNCVCRFSLDSSLS----KSVFPPETDFLLAFATVPGYVSFRSRTSGSFFIQELVEVIEKYHGSHHLLDMLTEVTRRVIDHQNREFDPARDRVQVPAPTHTLTKLLYL Acropora_digitifera_Adicasp20 ESFVRGSEQTEKEFEKEKLRQGSEKD-TISLQRLFEALDFKVRVN-NVTEKQLLKILGDVSKE-DHSNYHCFVLCLMSHGKEGQFYCADGKTVCLKEISNFFSNRNCETLKGKPKLFFIQACRGYVKDRG-VVEDSPSEQGPQQASFERDIIPNQADMLMAYSTVSGYASFRNPHYGSRFVRCLVEVFQEKASHEDVLSMLTNVNDKLS-----MGE--IDSKQVGQPTSTLRKKVYF Acropora_digitifera_Adicasp21 -------------------RFDFEQTHEP------------QISTQDLKRDQIKRVAQEYGG-ENHDKFVAFVLIVMSHGDKDRIFGVDNDWISVRELMKEFQAKKCPSLKGKPKILIIQTCR-TELYLADNPVDQFSLDSSLS----KSVFPPETDFLLAFATVPGYVSLRSRKSGALFIQVR------------------------------------------------------ Acropora_digitifera_Adicasp22 GIALIISNEHFGGNPLLRDRQGNKKD-IEHLQELWSFLNFQVEIRRDLNSQDIYNVMREIS-SLDHSQFDCFVCCLLSHGAHGGIYGTDSELVEIKDITALFKGVACPSLYNKPKLFFIQACRGQGFDR-----GARMQADAT--ALRHNAEPNESHFLLGYATPPGYVSWRSQIHGSWYISKLCEVFRNCCE-FDVTSMM------------------------------------- Acropora_digitifera_Adicasp3 ----VLVINNVNFYFTKDPRNGASHD-RDNIRAFVEEAGFEKFEEHDLTKRQMLDLFEETRLMEDLVEHDSFICIIMSHGDEEGILAADSQSVPVDSIIAKFQGNKCPQLATKPKLFFLQACRGKVDDNGYHVPEMQDQVIADAD----VKLPTDADVLIAYSTTKGYLSHRSTQLGSWFISCLVQIFLEYSHREDLMTMLTRVNNSLS-----LYSEPNGCKQISCQLSMLTKKVYF Acropora_digitifera_Adicasp4 GYCVIINNRQFQGNDEAY-RKGSEQDVERLRKLFK-SLRFEVIIKRDLERNHIEGVAQEYGR-KNHDKFVAFVLIIMSHGDEDCVLGVDNKPVSVRALMREFQAEKCPSLKGKPKILIIQTCR-TEFGLADNRMDQFLLDSSLS----KSVFPPETDFLLAFATVPGYVSFRSPTSGAFFIQELVEVIEKYHGSRHLLDMLTEVTRRVIDHQDQAFHPTRYRVQVPAPAHTLTKLLYL Acropora_digitifera_Adicasp5 GYCVIINNLQFQGNDEAD-RKGSEQDVEKLRNLFK-LLRFEVIIERELERDQIKGVAQEYGG-KNHDKFVAFVLIVMSHGEKDCIFGVDNDSISVRNLMKEFQAEKCPSLKGKPKILIIQACR-TEFGLADNLMDQFSVDSSLS----KSVFPPETDFLLAFATVPGYVAFRLPSSGALFIQELVEVIEKDHGSHHLLDMLTEVTRRVVDRQNQAVHPPKYRVQVPAPVHTLTKL--- Acropora_digitifera_Adicasp6 GIAIIINNKNFLRSSGMDKRNGTDVD-RDALKKLFESLKFEVRIYNDITKYEIRRIAKEMATF-NHSAYDAFIFSILTHGEEGLLYGTDG-TISTRDVTSAFKD--ATTLAGKPKMFFFQACQ-------------------------------EVN------------NWIGRVS-------------KNKQPARAARTSDRF--CVVLCKTS-ICHICGFEQTKVKLK-------- Acropora_digitifera_Adicasp8 GYCVIINNRQFQGNDKAY-RKGSEQDVERLRNLFE-SLRFQVIIKRDLKRDQIKGVAQEYGG-KNHDKFVAFVLIVMSHGDKDCIFSVDNDSISVRQLMKEFQAERCPSLKGKPKIFIIQTCR-TEFDLADNRVDPFSLDSSLS----KSVFPPETDFLLAFATVPGYVSLRSRKCGAFFIQVH------------------------------------------------------ Acropora_digitifera_Adicaspx GLCLIINNMTFK-EKNLN-RYDAIFDEERLHDLFAGKLDFEVHAFNDLDNCQMQAICTEFGG-KDHCQYDAFVCIIMSHGCGDKIKGVNGRTIGIDDLMSEFNIERCPSLANKPKLFLVQACR-CPTDKSQDIVDFTVSDSTLS----RSICPQESDFLLAFSTVPGYVSYRRPNFGSFFMQGVADVFEKDHDKDHVLDMLMKVNRQVSAASN----------QVPAIHSTLRFKVYL Acropora_millepora_Amil12671 GYCVIINNLKFQENEEAY-REGCGQDDKRLGNLFK-SLRFKVIIKRNLEKNQIERVAQEYGG-RNHDKFAAFVLIVMSHGDRDCILGVDNRTTSVGALMREFQAERCPSLKGKPKILIIQTCR-TEFDGADNCVGPFSLDSSLS----KSVFPPEADFLLAFATVPGYVSFRSKKSGAFFIQELVEVIEKYHGSHHLLDMLTEVTRRVIDHQNREFDPARDKVQVPAPTHTLTKLFFL Acropora_millepora_Amil12676 GYCIVINNLKFQENDEAY-RGGSEQDEERLGNLFK-SLRFEVIIKRNLEKNQIEEVAQEYGG-KNHDKFAVFVLIVMSHGNRDCILGVDNRMTSVRALMREFQAERCPSLKGKPKILIIQTCR-TEFDQADNCVCPFSLDSSHL----KSVFPPETDFLLAFATVPGYVSLRSPTSGAFFIQELVEVIQEYHDSHHFLDMLTEVTRRVIDHQDREFDRTRYRVQVPAPTHTLTKLLYL Acropora_millepora_Amil12678 GYCVIINNRQFQGNDEAY-REGSEQDVERLRKLFK-SLRFEVIIKRDLERNHIEGVAQEYGR-KNHDKFVAFVLIVMSHGDEDCVLGVDNKPVSVKALMKEFQAQKCPSLKGKPKILIIQTCR-TELYLADNRVDQFSLDSSLS----KSVFPPETDFLLAFATVPGYVAIRLPSSGALFIQELVEVIKMHHDSRHLLDMLTEVTRRVVDQQNKAVVPAKYRVQVPAPAHTLTKLLFL Acropora_millepora_Amil12876 --GYVLVINNVQFPGRRNPRSGSDED-VQRLVDLFQDFRFEIRESRDLERRDMMILLRDTSAR-DFTKYDCFVCVILSHGEKDGICGTDDEVITLEAITSLFRRDACPSLQGKPKIFLIQACRGTQRDQVSTE--------SDSD----PSLPADSDFLICFASAPGHECYREGLIGSWFICAIHKVFKEYAHKEHIMDMMLRVNNEVA-----YLSP-RGLKQMPCEICMLTKKVFF Acropora_millepora_Amil18519 GLALIFEVVNYFHEMDVPF--GSGVD-VERLEKLFKGIGYNVRVQRDPLSAEDFEIHLKYFLAKHAIG-DSVIVTVMAHGNEGVVCC-DGSIVSVDKIVSILG--NAVIYRGKP--------------------------------------------------------------------NLVEFFSQYAF--------------------------------------------- Acropora_millepora_Amil19957 GYCVIINNRQFQGNDEAY-RKGSEQD-ERLRNLFE-SLRFEVIIKRDLERYQIEGVAKEYGG-KNHDKFVVFVLIVMSHGHESHILGVDNKSISVGELMEEFQTERCPSLKGKPKILIIQTCR-TEFHRADNRIDPFSLDSSLS----KSVFPLETDFLLAFATAPGYVSFRSKKSGAFFIQELVDVIEKYHGSHHLLDILTEVTRRVIDHQNREFDPTRYRVQVPAPTHTLTKLLYL Acropora_millepora_Amil2288 GIALIIGNEHFGGNPSLRDRQGNKKD-IEHLQELWSFLNFQVEIRRDLNSQDIYNVMREIS-TLDHSQFDCFVCCLLSHGAHGGIYGTDSELVEIKDITALFKGVACPSLYNKPKLFFIQACRGQGFDR-----GARMQADAT--ALRHNAEPNESHFLLGYATPPGYVSWRSQIHGSWYISKLCEVFRKYCE-YDVTSMMVRVNDEVSEAFT-----KMGYKQCPAPVVTLRKRIYF Acropora_millepora_Amil26153 -HRLMINNMCFE-NEKFN-RPWAIHDEEKLQALFGNDLQFQVHVENDLQNFEMQQICTEYSK-KDHSKCDAFVCILMSHGVGDKIVGCREE----RSLMPDFKTERCPSLAGKPKIFFVQACR-RQGDESRDYIAGLTCDSTLA----SSISPQEADFLLAFATVPGYVALKRRDYGSFYIQALTEVIARNHNKDHLSDMLTAVNCRVADALN----------QVSPTHSTLRLKVFL Acropora_millepora_Amil779 ---------NI-WQFTKVPRNGATHD-RENIREFVKEAGFEKFEEHDLTKGQMLDLLEKTRLTGDLVMHDSFICIIMSHGDEEGILGADSQSVPVDSIIAKFQGNKCPQLATKPKLFFLQACRGKVDDNGYHVPEMQDQVIADAG----VKLPTDADVLIAYSTTKGYLSHRSTKLGSWFISCLVQIFLQYSHREDLMTMLTRVNNSLS-----LYSEPNGCKQISCQLSMLTKKVYF Acropora_millepora_Amil8100 ESFVRGSEQTEKEFEKEKLRQGSEKD-TISLQRLFEALDFKVRVN-NVTEKQLLKVLDDVSKD-DHSDYHCFVLCLMSHGKEGQFYCADGKTVCLKEISNFFSNRNCETLKGKPKLFFIQACRGYVKDRG-VVEDSPSEQGPQQASFERDIIPNQADMLMAYSTVSGYASFRNPNYGSRFVRCLVEVFQEKASHEDVLSMLTNVNDKLS-----MGE--IDSKQVGQPTSTLRKKVYF Acropora_millepora_Amil8447 GIAIIVNNKNFLSSSGMDERKGTDVD-RDALEKLFKSLKFDVRIYNDITTHRIKQIAREMASL-NHSDYDAFIFSILTHGKEGLLYGTDG-TISTRDLTSKFKV--ATTLAGKPKMFFFQACQGGRFMDGMDVPDGSDCE-----ASSKVSVPAEADFLYVYSTVPGYYSWRNSERGSWFIQSLTKVFEENAERMDILRMLTRVNAMVSTYKSR-RKDWDDKRQGNESKKEFLPQLQS Acropora_millepora_Amil8454 GIAIIINNKNFLRSSGMDKRNGTDVD-RDALKKLFESLKFEVRIYNDITKYEIRRIAKEMATF-NHSDYDAFIFSILTHGEEGLLYGTDG-TISTRDVTSAFKD--ATTLAGKPKLFFFQACQGHEYMDGMDVTDG--PQ-----ASSKVSVPSEADFLYAYSTVPGYYSWRNSVNGSWFIQSLTEVFEEKAERMDILRMLTRVNARVSTFKSR-EYYSDSKRQVSSIVSMLRKELYF Acropora_millepora_Amil9566 GFCLIINNMSFR-DQNLH-RLGANFDEQKLCDLFG-KLHFEVWLFKDQHKHQMEWICASYGGDVDHSQYDAFVCIIMSHGSGDKIIGVNGRKIGIEDLMSEFNAVRCPSLANKPKMFVIQACR-GPTD--QQIADITFSDSTLS----GSICPKESDFLLAYATVPGYVSYRRADFGSFFIQTLVDVFEKKHHKDHLEDMLTEVRRRVSGAVC----------QVSPSHTTLRYKVF- Acropora_millepora_Amil9586 GWCLIINNVDFEYHT----RGGSDID-AKQLKELFTKLQYKVQEHRNQTAAQLKNTVLQFSKMSGHKEADSMVFCLLSHGLEGQVYGCDGELVSISDLVAMFNGYEAKDLIGKPKMIFIQACRGVEYDH-----GADLEVTDNGFLFEPETIPAEADMLVAYSTVPGYVSWSHLQKGSWFVQALVDVFGSYAR-EDVVSMLVRVNGKVAKEFE----SYNRKKQIPAPVVMLTKKVFF Aiptasia_pallida_Aipq3hl92 GVAVIINNKSFLPASGMHRRNGTDVD-RDALDKVFQKLGFNTLVYNDQSVYEIQKIFKSLAAR-DYSKENALIVSILTHGEEGILYATDG-TIQIRDMMRWFK---GTNLVGKPKIFIFQACQGHEYMDGVDATDAP-PA-----DK-RVQIPVEADFLYAYSTVPGYYSWRNSVNGSWFIQSIAEVFDKYAKTTDLLTMMTRVNALVATHQSR-DPYSDRKKQIPSIVSMMRKDFYF Anemonia_viridis_Aviq09y99 GMAIIINNKTFLPSSGMHRRNGTDVD-RDALEKTFNRLMFNTLVYNNQSVYETQKIFKGLATK-DFSNENALVVCILTHGEEGILYATDG-TILIKDMMGWFK---GSNLVGKPKVFIFQACQGHEYMDGKDATDAP-PP-----DK-RVQIPVEADFLYAYSTVPGYYSWRNSVNGSWFIQSIVEVFNKYAKTTDLLTMMTRVNALVATYQSR-DPYSDRKKQIPSIVSMLRKDLYF Canis_lupus_familiaris_Canfcasp1 RLALIICNIEFDHLSTRDG---AELD-IAGMESLLEGLGYSVVVKRKLTAKGMESVLREFAARPEHKSSDSTFLVLMSHGILNGICGT---VLAYDTIFQIFNNRHCLNLKDKPKVIIIQACRGENPGELWVS--DSPKASTDSWSDAIHKVHVEKDFIAFCSSTPHNVSWRHITKGSLFIAQLITCFQKYSWCCHLEGVFRKVQQSFEKP--------DVKAQMPTIERVSMTRYFY Canis_lupus_familiaris_Canfcasp10 -HCVIVNNHTFAKMPD---RPGTDKD-AECLSRVFQWLGFSVHVYKNVTKGHLDEVLQEFKCHPDHVDGDCFVFCVLTHGKFGAVYSSDGTLVPIREIMSHFTAQKCPGLAHKPKLFFIQACQGKGIQT-----PVSIEADAVNPSLKD-SIPDAADFLLGLATVPGYVSFRHVEKGSWYIQSLCNRLKSLVP-EDILSILTAVNNDVSQQAD----KQGTMKQMPQPAYTLRKKLVF Canis_lupus_familiaris_Canfcasp12 RLALIICNSEFDYLSKRQG---SEID-ILGMQDLLENLGYSVVVKENLSALEMKTELKNFAARQEHKFSDSTFLVFMSHGTLDGICGT---ILHDDTIFQIFNNRNCRSLKDKPKVIIMQACRGRGDGAVWVT--DVGEASAWTCNDAIEKTHVEKDFIAFKSSTPHNVSWRLNTDGSLFISHLIHYFREFSCCHHLEEIFRKVQNSFETP--------NTMIQMPTIERVSMTRYFY Canis_lupus_familiaris_Canfcasp14 ---------------KARE--GSEAD-LDALERMFQQLGFESTMKRDPTAQQFQEELDKFQQAMDARDDSCAFVVLMAHGLEGRLKGEDGEMVELEDLFKVLNNKNCRALRAKPKVYIVQACRG-QRDPGETVSGD---------KDNPQTIPTYTDILHVYSTVEGYIAYRHDKEGSCFIQT------------------------------------------------------- Canis_lupus_familiaris_Canfcasp16 ----------------SRP--GAKHD-VEALGSLCQALNFKITLRTNPTAQAFQEEMVQFRECLDALSASCALVALMAHGPQGQLLGADGQEVQPEALVQELN--RCRALWGCPKIFLLQACRG-HRDAGVGPTALS--------RASP-TTPSHADVLEIYTDAQG-SASRGPTAGSSDQADILMVYAAAEGCVAYRDEKGSDFIQTLAEVL----RADPGGDLLELLTEVNRRV-- Canis_lupus_familiaris_Canfcasp2 -LALVLSNVHFT--GEKDLRSGGDVD-HSTLVTLFKLLGYKVHVLLDQTAQEMKEKLQNFAQLPAHRVTDSCIVALLSHGVEGGIYGVDGKLLQLQEVFRLFDNASCPNLQNKPKMFFIQACRGDETDRGVDQQDGKNHTGSSEC--LKTRLPTRSDMICGYACLRGTAAMRNTKRGSWYIEALTQVFSERACDTHVADMLVKVNALIKEREG-PGTEFHRCKEMSEYCSTLCRH--- Canis_lupus_familiaris_Canfcasp3 GLCIIINNKNFHKSTGMA-RSGTDVD-AANLRETFTNLKYEVRNKNDLTCEEILELMNSVSKE-DHSKRSSFVCVLLSHGDEGIIFGTNG-PVDLRKVTGFFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGIEDD------MACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKLYAHKLEFMHILTRVNRKVATEFESLDSAFHGKKQIPCIVSMLTKELY- Canis_lupus_familiaris_Canfcasp4 RLALIICNIEFDHLSTRDG---AELD-IAGMESLLEGLGYSVVVKRKLTAKGMESVLREFAARPEHKSSDSTFLVLMSHGILNGICGT---VLAYDTIFQIFNNRHCLNLKDKPKVIIIQACRGENPGELWVS--DSPKASTDSWSDAIHKVHVEKDFIAFCSSTPHNVSWRHITKGSLFIAQLITCFQKYSWCCHLEGVFRKVQQSFEKP--------DVKAQMPTIERVSMTRYFY Canis_lupus_familiaris_Canfcasp8 -YCLIFNNYDFSVARREVPRNGTDLD-ADALSKTFSELHFEIVHFKDATAKKICEVLQSYQ-SMDHSSKDCFICCILSHGDKGIIYGSDGQEAPIYELTSYFTGSKCPSLAGKPKIFFIQACQGDKYQK-----GIAVETDSEQKSYQKRYIPEDADFLLGMATVNNCVSYRNPMEGTWYIQSLCQSLRERCP-EDILTILTEVNFEVSNKDD----RKNMGKQMPQPTFTLRKKLFF Canis_lupus_familiaris_Canfcasp9 GYCLIINNVNFCPESRLT-RGGSNID-CEKLQRRFCLLRFTVEVKWDLTAKQMVQALVELARRD-HSALDCCVVVVLSHGFPGAVYGTDGCPVSIEKIVNIFNGTGCPSLGGKPKLFFIQACGGEQKDH-----GFAVASASPE-LDAVSSLPTPSDIFVSYSTFPGFVSWRNTKSGSWYVETLDGVFEQWAH-EDLQTLLLRVANAVS--------QKGVYKQIPGCFNFLRKKLYF Canis_lupus_familiaris_Canfclar -------------------------NDTDFLRDTFTSLGYEVQYFLYLNVDSIIQILRQVARMPQHQDYDSFVCVLVSRGGSQSVFGVDHTGFPLDQVRRMFMGDACPFLLGKPKLFFIQNYVVGQMDSSSFLEVDGPEVNNVES---PCTIHREADFLWSLCKADVSLLEQ--GSPSLYLKCLSQKLGQDRRR--LLELHTELNSSVYDWNSRAKERYYVWLQHTLR---------- Fugu_rubripes_Fugcasp3 -HCIIINNKNFDRRTGMN-RNGTDVD-AANAMKVFLSLGYKVKVHNDQTVNQMKQLLVSAAEE-DHSACASFVCVLLSHGDEGVFFGTDG-SVELKYLTSLFRGDRCKSLVGKPKLFFIQACRGNDLDGGIETDSAADS--------STTKIPVEADFLYAFSTAPGYYSWRNTTSGSWFMQSLCDAISKYGKELELQHILTRVNHKVAVDFESNLPGFDAKKQIPCIVSMLTKEMYF Fugu_rubripes_Fugh2sku3 -VALVITN-----ITFFQG---AEKD-EENMETLLKGLGYEVVKYRNLTGRAIEDAVIDFSKRPKLKDTDSVVVVIMSHGRLGVVAGVS--HFSLDKMYRLLGPEHCPALLNKPKIIIIQACRGDERGEIIFN----DQHPPENPEDAIRIEHKEKDFVSLLSCTPDTVSYRALAKGSFLVQVLVDVFNASVERDDLEELFRKVQHRFEDFPI------GNRRQMPTKDRCTLTKRFY Fugu_rubripes_Fugh2thl4 GLCVIINNENFLDMKQ---RSGTNKD-AQSLAEVFTWLGFRVLMCKDQTKEKMDRALNCFASLVDPKHGDAFICCILSHGEKSAVLGIDGEPLCIKQIIRTFKATRQSALVSKPKMFLIQACQGKGTHR-----GVLLK-DLQTD-CHTLSIPEEADILVATATVEDYVSFRHKIDGSWFIQSLCQELKEGCL-EDMTTILHRVNSEVSQKEAF--IHPGEQKQMPEVRFTLRKRLVL Fugu_rubripes_Fugh2uky4 GFALVISNVTFNPCAAPELRKGGEVD-DEVLRKVFTELEYSVTVQRDLTAQGIKTCIQNFSGRPEHRSVDSCVVCLLSHGVEGAVYGIDGELLQLDWVFEAFDNAHCPLLQNKPKMFFIQACRGDEMDCGVEQIDGPSRTSSPSCCRPRIKLPQRSDMICGFASLKGTAAMRNTK-GSWFIQELNTALRLHARDRHLADILVQVNRRIKDREG-PGTAHHRCKEMSEFTSSLCKDLFL Fugu_rubripes_Fugh2v832 GHCLIINNVDFEPRSELN-RKGSNTD-CDRLESRFKALNFIVKVKTNLKQRQIKHELSALSKMD-HSQYDCCVVVLLSHGFPGAVYGVDGQFVPVQHITTYLNGQHCPSLQGKPKLFFIQACGGDEKDT-----GFEVSPDEFE-PDARASLPTPSDILVSYSTFPGYVSWRDTQSGSWYIETLDRILEENAA-DDLVTMLMMVNHEVSQN-Q----AKGLYKQMPGSFNFLRKLLYF Gallus_gallus_Galcasp1 RRALLICNTKFKHLRQRDG---AEVD-VKEMTKLLEGLGYNVECHEDKTSQEMTTVMKKFADHKDHLTSDSTFLVFMSHGMSTGICGT---ILSFNTIYENFNNKHCRALMGKPKVVIIQCCRGDNIGSVQIRDSIDPEMPTSTSGSKTREAHLESDFATLYSSTPDTVSWRSPTEGSVFIQRLVEQFRNHAFNSDLQEMFRKVQRSFEN----------FPRQLPTQERTTMLKKFY Gallus_gallus_Galcasp10 GICLVINNVKFDGVLQE--RKGSYKD-ACELERVFTWLGLDVRTYTDQTSDQIKELMQAWQRSEDHKNRDCFVCCILSHGESGAVYGKDGKLVSIRTIMTYFTAKQCPQLTEKPKLFFVQACQGKEVQR-----PVYVETDARVPSPSE-SIPEEADFLLGMATIDGYASFRHVQEGTWYIQALCSKLQLLVPSEDILSILTEVNEDVSKRVD----RYGTRKQMPQPAYTLRRKLIF Gallus_gallus_Galcasp18 GYCVILNNYRFKNPNET--RKGTVED-GKALKRVFKWLQFDTIEYMDLEAKQIFAKVNEYS-KKDHSNMDCFVCFILSHGEKGKIKGVDNELVNIKDLLSCFSGSNCPSLAGKPKLFFIQACQGSVGHP-----AVTVKEDCSG-AIPALSIPDQADVLVGMATVEDFECYRSIETGSVYIQCLCDKMELLCP-KDLITILTEVNKEVGRRVL------NGWKQMPKITSTLRKQFIF Gallus_gallus_Galcasp2 GLALILSNIHFS--SEKDLRSGGDVD-CASLELLFKHLGYQVTVFHDQSAEEMESALERFSKLPDHQDVDSCIVALLSHGVEGGVYGTDGKLLQLQEAFRLFDNANCPNLQNKPKMFFIQACRGDETDRGVDQRDGKEWSDSPGC--LKLRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALTTVFAEDSRDTHVADMLVKVNRQIKQREG-PGTEFHRCKEMSEYCSTLCRDLYL Gallus_gallus_Galcasp3 GVCVIINNKNFHRDTGLS-RSGTDAD-AASVREVFMKLGYKVKLNNDLSSRDIFKLLKNVSEE-DHSKRSSFVCVLLSHGDEGLFYGTDG-PLELKVLTSLFRGDKCRSLAGKPKLFFIQACRGTELDSGIEADSGPDE-------TVCQKIPVEADFLYAYSTAPGYYSWRNAAEGSWFIQSLCRMLKEHARKLELMQILTRVNRRVA-EYESTRQDFNAKKQIPCIVSMLTKEFYF Gallus_gallus_Galcasp7 GKCIIINNKNFEDKTGMG-RNGTDKD-AGDLSKSFRSLGFDVYTYNDRSCEDMQTLLKQAAEE-NHSDAACFACILLSHGEEGLIYGTDG-PMAIKHLTTLFRGDKCKTLIGKPKLFFIQACRGSEFDEGIQTDSGPANDTLETDANPRYKIPVEADFLFAYSTVPGYYSWRNPGRGSWFVQSLCSVLNEHGKQLEIMQILTRVNYVVATNFESDDPRFSEKKQIPCVVSMLTKELYF Gallus_gallus_Galcasp8 GVCLILNNHNFAKAREAVPRNGTHVD-ADALRKVFSNLHFTVAEYKDCTAEEIRNIVNNYR-CMDHNNKDCFVCCILSHGKKGIIYGVDGQEVPIQELTTSFTGQNCQSLAGKPKVFFVQACQGDAYQK-----GVTIETDSGEQRFQLDCIPSEADFLLGMATLQDYVSYRSPSQGTWYIQSLCQHLESSCP-EDILTILTAVNQEVSSKID----KQNAGKQMPQPSFTLRKKLIF Gallus_gallus_Galcasp9 GHCLIFNNVSFSRDSDLS-RAGSDID-CEKLEKRFRSLCFHVRTLRNLKAQEIDVELRKLARLD-HSALDCCLVVILSHGFPGGIYGTDGKIIPIERIVNYFNGSQCPSLRGKPKLFFIQACGGEQKDQ-----GFEVDCESPQ-PDAVASLPTPGDILVSYSTFPGFVSWRDKVSGSWYVETLDSVLEHYAR-EDLLTMLLRVSDIVS--------TKGRYKQIPGCFNFLRKKFFF Homo_sapiens_Humcasp1 RLALIICNEEFDSIPRRTG---AEVD-ITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGK---ILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFK---DSVGVSGNLDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQP--------DGRAQMPTTERVTLTRCFY Homo_sapiens_Humcasp10 GLCVIVNNHSFTSLKD---RQGTHKD-AEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQP-----SVSIEADALNPSLQD-SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKL----------------------------------------------- Homo_sapiens_Humcasp14 -------LALILCVTKARE--GSEED-LDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDSCAFVVLMAHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRG-QRDPGETVGGD---------KDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQ----EGKARKTNPEIQSTLRKRLYL Homo_sapiens_Humcasp2 GLALVLSNVHFT--GEKELRSGGDVD-HSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGC--PKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREG-PGTEFHRCKEMSEYCSTLCRHLYL Homo_sapiens_Humcasp3 GLCIIINNKNFHKSTGMT-RSGTDVD-AANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKE-DHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDD------MACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFDATFHAKKQIPCIVSMLTKELYF Homo_sapiens_Humcasp4 RLALIICNTEFDHLPPRNG---ADFD-ITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGT---VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVR--DSPASLEVASEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETP--------RAKAQMPTIERLSMTRYFY Homo_sapiens_Humcasp5 RLALIICNTKFDHLPARNG---AHYD-IVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGT---VLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVR--DSPASLALISADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVP--------QAKAQMPTIERATLTRDFY Homo_sapiens_Humcasp6 GIALIFNHERFFWHLTLP-RRGTCAD-RDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTV-SHADADCFVCVFLSHGEGNHIYAYDA-KIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDKDPSAIGKKQVPCFASMLTKKLHF Homo_sapiens_Humcasp7 GKCIIINNKNFDKVTGMG-RNGTDKD-AEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEE-DHTNAACFACILLSHGEENVIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPIN---DTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESDDPHFHEKKQIPCVVSMLTKELYF Homo_sapiens_Humcasp8 GYCLIINNHNFAKAREKVPRNGTHLD-AGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ-LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQK-----GIPVETDSEE-SPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCP-DDILTILTEVNYEVSNKDD----KKNMGKQMPQPTFTLRKKLVF Homo_sapiens_Humcasp9 GHCLIINNVNFCRESGLR-RTGSNID-CEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQD-HGALDCCVVVILSHGFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDH-----GFEVASTSPE-LDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAH-EDLQSLLLRVANAVS--------VKGIYKQMPGCFNFLRKKLFF Homo_sapiens_Humcaspc -----IRNKEFNYLHNRNG---SELD-LLGMRDLLENLGYSVVIKENLTAQEMETALRQFAAHPEHQSSDSTFLVFMSHSILNGICGT---VLHDDTIFEIFNNRNCQSLKDKPKVIIMQACRGNGAGIVWFTT-DSGKAGADTHNDAVTKAHVEKDFIAFKSSTPHNVSWRHETNGSVFISQIIYYFREYSWSHHLEEIFQKVQHSFETP--------NILTQLPTIERLSMTRYFY Homo_sapiens_Humcflar -------------------------NETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVGQLEDSSLLEVDGPAMKNVEF---LCTVHREADFFWSLCTADMSLLEQ--SSPSLYLQCLSQKLRQERKR--LLDLHIELNGYMYDWNSRAKEKYYVWLQHTLRKKLILSYT-- Mus_musculus_Mousecas1 RLALIICNTEFQHLSPRVG---AQVD-LREMKLLLEDLGYTVKVKENLTALEMVKEVKEFAACPEHKTSDSTFLVFMSHGIQEGICGT---ILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEKQGVVLLK---DSVRDS-EEDDGIKKAHIEKDFIAFCSSTPDNVSWRHPVRGSLFIESLIKHMKEYAWSCDLEDIFRKVRFSFEQP--------EFRLQMPTADRVTLTKRFY Mus_musculus_Mousecas12 RLALIICNKKFDYLFDRDN---ADTD-ILNMQELLENLGYSVVLKENLTAQEMETELMQFAGRPEHQSSDSTFLVFMSHGILEGICGV---VLHDDTIFKIFNNSNCRSLRNKPKILIMQACRGRYNGTIWVST-NKGIATADTDNNSITKAHVETDFIAFKSSTPHNISWKVGKTGSLFISKLIDCFKKYCWCYHLEEIFRKVQHSFEVP--------GELTQMPTIERVSMTRYFY Mus_musculus_Mousecas14 ---------------KARE--GSEVD-MEALERMFRYLKFESTMKRDPTAQQFLEELDEFQQTIDNWEESCAFVVLMAHGEEGLLKGEDEKMVRLEDLFEVLNNKNCKALRGKPKVYIIQACRG-HRDPGEELRGNEELGGDEELKNNPQSIPTYTDTLHIYSTVEGYLSYRHDEKGSGFIQTLTDVFIHKKGSILELTEEITRLMANTEVMQ----EGKPRKVNPEVQSTLRKKLY- Mus_musculus_Mousecas2 -LALVLSNVHFT--GEKDLRSGGDVD-HTTLVTLFKLLGYNVHVLHDQTAQEMQEKLQNFAQLPAHRVTDSCVVALLSHGVEGGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHTQSPGC--MKMRLPTRSDMICGYACLKGNAAMRNTKRGSWYIEALTQVFSERACDMHVADMLVKVNALIKEREG-PGTEFHRCKEMSEYCSTLCQQ--- Mus_musculus_Mousecas3 GICIIINNKNFHKSTGMS-RSGTDVD-AANLRETFMGLKYQVRNKNDLTREDILELMDSVSKE-DHSKRSSFVCVILSHGDEGVIYGTNG-PVELKKLTSFFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGTDEE------MACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCSMLKLYAHKLEFMHILTRVNRKVATEFESLDSTFHAKKQIPCIVSMLTKELYF Mus_musculus_Mousecas4 RKALIICNTEFKHLSLRYG---ANFD-IIGMKGLLEDLGYDVVVKEELTAEGMESEMKDFAALSEHQTSDSTFLVLMSHGTLHGICGT---VLQYDTIYQIFNNCHCPGLRDKPKVIIVQACRGGNSGEMWIR--ESSKPQLCRGADAVKLSHVEKDFIAFYSTTPHHLSYRDKTGGSYFITRLISCFRKHACSCHLFDIFLKVQQSFEKA--------SIHSQMPTIDRATLTRYFY Mus_musculus_Mousecas6 GVALIFNHERFFWHLTLP-RRGTNAD-RDNLTRRFSDLGFEVKCFNDLRAEELLLKIHEVSTS-SHIDADCFICVFLSHGEGNHVYAYDA-KIEIQTLTGLFKGDKCQSLVGKPKIFIIQACRGSQHDVPVVPLDMVDHQTDKLDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLARYGSSLEFTELLTLVNRKVSQRRVDKDPDAIGKKQVPCFASMLTKKLHF Mus_musculus_Mousecas7 GKCIIINNKNFDKATGMD-RNGTDKD-AGALFKCFQNLGFEVTVHNDCSCAKMQDLLRKASEE-DHSNSACFACVLLSHGEEDLIYGKDG-VTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPIN---DIDANPRNKIPVEADFLFAYSTVPGYYSWRNPGKGSWFVQALCSILNEHGKDLEIMQILTRVNDRVARHFESDDPRFNEKKQIPCMVSMLTKELYF Mus_musculus_Mousecas8 GYCLIINNHDFSKAREDITRKGTDCD-KEALSKTFKELHFEIVSYDDCTANEIHEILEGYQ-SADHKNKDCFICCILSHGDKGVVYGTDGKEASIYDLTSYFTGSKCPSLSGKPKIFFIQACQGSNFQK-----GVPDEAGFEQQSSHKNYIPDEADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRERCP-DDILSILTGVNYDVSNKDD----RRNKGKQMPQPTFTLRKKLFF Mus_musculus_Mousecas9 -HCLIINNVNFCPSSGLG-RTGSNLD-RDKLEHRFRWLRFMVEVKNDLTAKKMVTALMEMAHRN-HRALDCFVVVILSHGFPGAVYGTDGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQACGGEQKDH-----GFEVACTSSQ-LDAVSSLPTPSDILVSYSTFPGFVSWRDKKSGSWYIETLDGILEQWAR-EDLQSLLLRVANAVS--------AKGTYKQIPGCFNFLRKKLFF Mus_musculus_Mouseclar -------------------------NDTKYLQETFTSLGYHIQLFLFPKSHDITQIVRRYASMAQHQDYDSFACVLVSLGGSQSMMGRDQVGFSLDHVKNMFTGDTCPSLRGKPKLFFIQNYESSQLEDSS-LEVDGPSIKNVDS---HCTTHPEADIFWSLCTADVSHLEK--SSSSVYLQKLSQQLKQGRRR--LVDLHVELMDK------------------------------- Nematostella_vectensis_Nemve201 GICLIISNQHFD-KPELRKRDGNEQD-VENLKRTFENLHFVVEIRQDKTASEMYTIAREFS-SIDHSAYDLFVCCILSHGMLGSIYGSDSNLIEINEISSQFKGNACPTLAHKPKLFFIQACRGQDFDR-----G--IQADATR-AVRQNAEPNESHFLLGYATPPGYVSWRSQVHGSWYISFLCEVLSTYCE-YDLVTMMVKVNDKVSEAFT-----RKGYKQCPAPVVTLRKRIYL Nematostella_vectensis_Nemve202 ---YVLIINNQEFPSRSDVRKGSAED-VKQLYQLFDDFGMTVKTIQNKTSLEMLELLEETSEK-DFTKFDCFICIILSHGSHSGIYGVDEKAVQVESLTNKFRGSTCPSLQGKPKVFFLQACRGAKKELVAVE--------SDSE----SGLPSDSDFLICYASSPGYESYRNPELGSWFIRSIVDVFRNFGETEHLMDLMLRVNHRVA-----LNSN-LGHKQMPSEVCMLTRKVYF Nematostella_vectensis_Nemve203 ------------------------------------------------------------------------ICVIMSHGGKNGILTNDLNFVDVDEITGKFQGTNCPQLATKPKLFFIQACRGDDVDKGYRG-------HRNHH----VTLPSEADFLIAYSTTKGKVSFRLASMGSWFISCLVDVLLAYSHREDLMSMLTRVNHAMA-----LYSN-AGNKQMACQLSMLTKKLYF Nematostella_vectensis_Nemve205 KKFD-----SSLKFPSEKFRLGSDKD-TASLVRLWKAYDFEVPEPYDLSYDETKAAVNKLALK-DYSQYDCLAIFLMSHGKEDFIYTSDGGELKINEIRKRFSNARCRSLAGKPKLFFIQACRGEKKDFGTIVQDGPKTPEEHQEHNKGASTAEMADFLLAYSTVGGHASFRNTADGSRFIRALVTTFALHSGSEDVLSMLTRVNREVN-----QGD--IGNKQVSQPETTLTKKLFL Nematostella_vectensis_Nemve206 GVAVIINNKDFLPASGMHRRNGTNVD-RDSLEKTFKALQFDVEVHNNKTTYETNRIIKELGQR-SYSNYNAMIFAILTHGEEGILYTTDG-TIEIRSMMKAFK---GDNLVGKPKIFIFQACQGHEYMDGKDATDAG-PE-----DANRVQVPVEADFLYAYSTVPGYYSWRNSVNGSWFIQSICEVFNKHMHNMDVLRMMTRVNSLVSTYQSR-DYYSDRKKQVPSIVSMLRKDLFF Nematostella_vectensis_Nemve207 GWCLIINNVRFDADSGLK-RAGSDID-ASNLQSLFMSLRYRVKRLNDLTMRQMKNTLFDFAKNN-HKNSDSVVVCILSHGLEGRIYGVDGGLLNISDVISMFNGYQAKDLIGKPKLFFLQACRGGDFDH-----GARMEQIDS--------LPSEADFLIAYATVPGYVSWRHQEKGSWFIQALVEVFKTDAT-EDVLSMLIKVNRKVALEFE----SFNRKKQMPSPVVMLTKKLFF Nematostella_vectensis_Nemve210 GICLIINNMNYIGNR----RNGANNDVNALRRLFK-DLHFCVIIKTDLASRDLRETFQEYAM-MDHSNFDAFACVIMSHGEGDVLNCMDGRDVRLEDLMTEFKSLHCATLAGKPKMFFVQACRLSTPSFDSIPGEVLERDSSLP----RSLNPVEADVLLAYATPPGYVAYRSPTDGSFFIRALVETMREYHQKYHLLEILTLVNGVV------------------------------ Stylophora_pistillata_Stpg8xqy3 GIAIIINNKEFLRTSGMDRRNGTDVD-RDALQKLFRMLKFDVRVYNNRTRAEINRIAKEMATY-NHSNYDAFIFSILTHGEEGVIYGTDG-TLTIKEITSEFKY--SASLAGKPKLFFFQACQGHEYMDGMDVTDA--PQ-----DN-RVSVPAEADFLYAYSTVPGYYSWRNSVNGSWFIQSLTKVFEDNAERMDILRMLTRVNAMVSTYKSR-DHYSDSKRQISSIVSMLRKELYF Tetraodon_nigroviridis_Tetncflar --------------------------DGDLLEQTFRALHFSVVVHRWLRGFEILTTLKETMRQRECTEGDVFACCIISRGTSNHLLGTDSHGLHVNSIRRQFAANECLALAGKPRLLFLHKYSVFQMHNGREHRDEDLETDGLSG-----LIPENADTFWSHCWTDGHQLEK--IHCSVYVRALTDALLKAHRRLHLNELHMDVNRVV------------------------------ Tetraodon_nigroviridis_Tetngcasp2 -LALVISNVRFSPFAAPDLRQGGEVD-DEVLRKVFTELDYLVTVQRDLTAQGIKTCIENFSRRPEHQSVDSCVVCLLSHGVEGAVYGVDGKLLQLDWVFTAFDNAHCPLLQNKPKMFFIQACRGDEMDCGVEQIDGPSRTGSPSC-RPRIKLPQRSDMILRSKSPSGTAAMRNTKRGSWFIQELNKALRLHARDK------------------------------------------- Tetraodon_nigroviridis_Tetngcasp3 -HCIIINNKNFDRRTGMN-RNGTDVD-AANAMKVFSNLGYRVRVHNDQTVAQISQLLTSAAKE-DHSRCASFVCILLSHGDEGVLYGTDG-PMEIKSLTSLFRGDRCRSLVGKPKLFFIQACRGNDLDGGIETDSIEDN--------STTKIPVEADFLYAFSTAPGYYSWRNTMSGSWFMQSLCDTISKYGKELELQHILTRVNHKVAVEFESSLPGFNAKKQIPCIVSMLTKEMYF Tetraodon_nigroviridis_Tetngcasp6 -LAIIFNQESFFWRLGLK-RHGTNAD-SYNLQRRLRELNFDVNVYNNYKQQEVLDIINAAAKA-DHSDVDCFLLVFLSHGENDHIYANDD-KISIQDITSLFKGDKCKSLVGKPKIFIWQACRGDKHDEPATAAAFDDVDSESKKASAVHTLPAGADFIMCYSVAEGYYSHRETVNGSWYIQDLCDLLLRYGDSLEFTELLTLVNRKVSMRSVGRDPNAIGKKQVPCFASMLTKKLYF Tetraodon_nigroviridis_Tetngcasp7 GKCIIINNKNFDEKTGMN-RNGTDRD-AGELYKCFKSLGFDVFIYNDQTCEKMEHLLREASEE-DHSDSSCFACILLSHGEEGMIYGTDG-AMPIKTMTSMFRGDMCKSLVGKPKLFFIQACRGSEFDDGIQTDSGPPNDTMETDANPRHKIPVEADFLFAYSTVPGYYSWRNPGRGSWFVQALCNVLNEFGKQLEIMQILTRVNYMVATSFESEDPRFSEKKQIPCVVSMLTKELYF Tetraodon_nigroviridis_Tetngcasp8 GLCVVFNNEFFPRTGLR--RAGTIEDDADSLRAVFTKLGFTVVVHKDLTATDIERELQRLA-NRNFVNEDALVVCVLSHGQKGCFYGTDGATVKIQDVTQPFTSTRVPTLAGKPKLFFIQACQGDDLQMGCVPCPPRPAQNVDMEFVRGETVPDGADFLLGMATVQDYKAFRNTTTGSIYIQELCSPVTKSAESDDILSILTRVNREVSKGVF-----QWRKKQMPEPKYTLTKK--- Tetraodon_nigroviridis_Tetngcasp9 -HCLIINNVEFEPKSGLS-RNGSNVD-CDRLERRFKALNFTVKVKTNLKQRQIRQELSALSKVD-HSQYDCCVVVILSHGFPGAVYGVDGQFVPVQHIATYLNGQYCPSLQGKPKLFFIQACGGDEKDT-----GFQVSPDEFE-PDARASLPTSSDILVSYSTFPGYVSWRDPKAGSWYVETLDRVLEENAA-HDLVVMLTMVNDEVSQN-Q----AKGLYKQMPGSFNFLRKRLYF Xenopus_tropicalis_Xencasp1 RFALIICNEKFETLTERQG---AKVD-LDGMTKLLNELGYQVLQETNLAKEEMLKVLKEFAAREEHVDSDSTFIVLMSHGDKPGVCGTDSKLLQTDEIFSIFNNIHCPKLRDKPKVIIIQACRGEERGQKLVC---------DAVDDALHRVQRETDFICFCSSTPDTVSWRHPTMGSLFITGLIKKMNELAHCQPLMDIFLEVQSSFK-----------GQRQMPTQERSTLTKKFY Xenopus_tropicalis_Xencasp10 GYCLIIDNSVFMKGNR---REGSDKD-AGALSDVFSWLGLEVDIFENLMSEQIRDCLKRFK-SRDHSERDCFVCCILTHGESGTVMGSDDKEVSIREIMSYFTAISCTSLVLKPKLFFIQACQGKFTHP-----SSKVEADAIVPKYVV-NVPKDADFLLGMSTVDGYAAYRHTREGSWYIQALCKNLVELVP-EDILAILTKVNKDVSLKEG----QQGILKQMPQPSYTLLKKLRF Xenopus_tropicalis_Xencasp2 -RALIISNVAFE--T-QDLRYGGEVD-VTSLEKLFSSLGFQVEVRRNLNAQNMMSQLGAFSALPAHSALDSCVVAVLSHGLDGAVYGTDGKLVQLQDVFTAMDNAHCPQLQNKPKMFFIQACRGEEADRGVDQRDGREQSASPGC--IKVRLPTQSDMICAYACLKGTVSLRNTKRGSWFVQDLVSVFSQYSKNTHVADMLVKVNALIKEREG-PGTEFHRCKEMSEYCSTLCRDLYL Xenopus_tropicalis_Xencasp3 GICLIINNKNFQSSTNMG-RNGTDVD-ARKLHETFTGLGYKVKVCNDQKSNDIFTLLKKMSEE-DHSKRSSFVCAILSHGEDGLVYGVDG-PIQIKNLTDLFRGDRCKTLVGKPKLFFIQACRGTDLDSGIETDSGSEPG------EEIQRIPVEADFLYAYSTVPGYYSWRNTMNGSWFIQSLCEMIKLYGPHLELIQILTCVNHMVALEFESTQQAFHAKKQIPCVVSMLTKAFYF Xenopus_tropicalis_Xencasp6 GLALIFNHEDFYWQLRLG-RRGTNTD-SMNLNRILTDLGFDVQNYYNLRTLDILEKIQEASTA-DHSNADCFLCVFLSHGEDRHIYSYDS-LIDIQELTNSFKGDKCESLVGKPKIFIFQACRGEKHDNPVLPTDETD--SVTLTAASLYTLPAGADFIMCYSVAEGYYSHRETVNGSWYIQDLCEVLKAHAASLEFTEILTLVNRKVSQRSVANDPKAIGKKQIPCFSSMLTKKLFL Xenopus_tropicalis_Xencasp7 GRCIIINNKNFDDITGMS-RNGTDID-ARDLLRCFKGLGFDVTVFNNKSCTEMETLLRSVAEQ-DHKDSACFACIFLSHGEEGLIYGTDG-AMPIKVLTTLFRGDKCRSLVGKPKLFFIQACRGCEFDDGLETDAGPSNDSLETDANPRHKIPVEADFLYAYSTVPGYYSWRNPGRGSWFVQALCNVLNEHGKELEVMQILTRVNYLVATQFESDDPQFNKKKQIPCVVSMLTKELYF Xenopus_tropicalis_Xencasp9 ---------------------------------------------------AIHDHLEELAAQD-HSLRDCCLVVILSHGFPGGVYGTDGIRIPVERIVSYFNGSKCPSLRGKPKIFFIQACGGDQKDK-----GCSVT--------------------------------------------------------------------------------------------------- Xenopus_tropicalis_Xencflar -------------------------NDASLLENTFKSLHFTVMIHRYCIIEQLESILKDVANMEQHINHDIFVCIIISRGNDDSIFCTDSSGFSLDRIKYFFTGKSCPRLVGKPKLFFIQNYIAGDKDLDNMLEADGPTTVCANR-----NIPVEADIFWSHCKVEEIYLQQ--SLPSLYFRFLSQLLNDVEKRKHLLDIHTELNRIVRDK----KEECIIYQQHTLTKKLFF----- ; END;