#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 19, 2025; 3:59 GMT TreeBASE (cc) 1994-2008 Study reference: Olivera I., Fins K., Rodriguez S., Abiff S., Tartar J., & Tartar A. 2016. Glycoside hydrolases family 20 (GH20) represent putative virulence factors that are shared by animal pathogenic oomycetes, but are absent in phytopathogens. BMC Microbiology, . TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S19919] BEGIN TAXA; TITLE Untitled_Block_of_Taxa; DIMENSIONS NTAX=69; TAXLABELS Achlya_hypogyna Aedes_aegypti Anopheles_gambiae Aphanomyces_astaci Aphanomyces_invadans Apis_mellifera_Hex1 Apis_mellifera_Hex2 Arabidopsis_thaliana_Hex_2 Arabidopsis_thaliana_Hex1 Arabidopsis_thaliana_Hex3 Aspergillus_nidulans Aspergillus_oryzae Beauveria_bassiana Beauveria_bassiana_KGQ03395_ Blastocystis_hominis Bombyx_mori_Hex1 Bombyx_mori_Hex2 Candida_albicans Capsaspora_owczarzaki Choristoneura_fumiferana Coccidiodes_posadasii Cordyceps_bassiana Danio_rerio_Hex1 Danio_rerio_Hex2 Dictyostelium_discoideum Drosophila_melanogaster_Hex1 Drosophila_melanogaster_Hex2 Drosophila_melanogaster_Hex3 Drosophila_pseudoobscura_Hex1 Drosophila_pseudoobscura_Hex2 Drosophila_pseudoobscura_Hex3 Entamoeba_histolytica_Hex1 Entamoeba_histolytica_Hex2 Fenneropenaeus_chinensis Homo_sapiens_Hex1 Homo_sapiens_Hex2 Lagenidium_giganteum Magnaporthe_grisea Manduca_sexta Metarhizium_anisopliae Mus_musculus Mus_musculus_Hex2 Neotyphodium_sp. Oriza_sativa_Hex1 Oriza_sativa_Hex4 Oryza_sativa_Hex2 Oryza_sativa_Hex3 Oryza_sativa_Hex5 Ostrinia_furnacalis Pan_troglodytes_Hex1 Pan_troglodytes_Hex2 Phaeodactylum_tricornutum Rattus_norvegicus_Hex1 Rattus_norvegicus_Hex2 Saprolegnia_diclina Saprolegnia_parasitica Solanum_lycopersicum Solanum_tuberosum Spodoptera_frugiperda_Hex2 Spodoptora_frugiperda_Hex1 Streptomyces_cyaneogriseus_ Streptomyces_olivaceoviridis Streptomyces_toyocaensis Thraustotheca_clavata Tribolium_castaneum Trichoderma_atroviride Trichoderma_harzianum_Hex1 Trichoderma_harzianum_Hex2 Trichoplusia_ni ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M38300] TITLE Glycoside_hydrolases_family_20_Protein_Alignment; LINK TAXA = Untitled_Block_of_Taxa; DIMENSIONS NCHAR=443; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 ] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] Achlya_hypogyna PAYSHRGIVLDTARNYYSIDSLKRLVDTMGANKLNTFHWHFSDSSSFPFEIKSEPRLTSYGAYS-----K-DQVYTQDQIRDFVQFAKARGVRIIPELDAPSHAGAGWQWGPKAGYGELTLC---YG--SDPW-MDYC----LEPPCGQ----LNPLNDHVYDILKTVFEE------MHG-------LFD-SNVFHMGGDEVSVPCWNSS---KVITDHLKNTT----SNAPFFDLWGTFQTKAGALIEKA--------------NKKIMVWTSDLTTDPYLKYFK---PSNTIVQLWGG----STDGDAER-LTSKGYEVVASYWDAYYLDCGFGG---WVSKGN-------------------------GWC-APYKSW----QVIYDLDVRA---NLTAT-NAKRVLGSEVAMWSEIADEK-AVEAKIWPRAAALAERLW Aedes_aegypti PRFSHRGLLVDTSRHFVTLCTLIKILDGMAYNKLNVFHWHIVDDHSFPYQSKVYPELSDQGAYH-----P-SMIYTPHDVQNIIEEARLRGIRVISEFDTPGHTRS-WGVSH---PQLLTAC-------------YDQ----YRGKLGP----MDPTKESTYTFLFKLFQE------IVE-------VFP-DQFVHLGGDEVGFECWASN---PDVMEYMKQNR----L-YSFEMLEEKFIQRIVD-QIDV----L---------NRSSLVWQEVYVNGVRL-------PNGTVVHVWTG----NRQDLLYR-ITSDGLPALLSSC--WYLD--------HLSTGG-------------------------DWR-KFYNCD----PHDFVGTQK----------QKNLVLGGEACMWAEVVNDH-NILQRIFPRVSATAEKLW Anopheles_gambiae PAFPHRGLALDTSRNFIDLESLRRTLDGMAMVKLNVFHWHITDSQSFPLVVKSRPTLHTYGAYS-----R-RDVYTADDVQRLVQYALERGIRIVPELDAPAHVGEGWEKLG------VTAC---FN--YQPW-ENYC----VEPPCGQ----LDPTKDAVYDILEDVYRE------MNA-------MFNRSDLFHMGGDEVSVRCWNAT---GSIQRWMGEQEWGL-QEGDFMKLWNYFQTEALRRLDKTLPVAEGGK------PRPIVMWTSKLTESPYLEQYL--DKDRYIVQVWTT----GNDSKVAN-LLQKGYRLIMSNYDALYLDCGFAG---WVTDGS-------------------------NWC-APYIGW----QKVYNNDLMA----IGGP-YAQQILGGEAALWTEQSDTH-TLDNRLWPRLSAHAERLW Aphanomyces_astaci PAYKYRGVMLDTARNFHSMAAIKRLVRTMGMHKLNMFHWHITDSSSFPIEIKFEPKFNLYGNYQ-----S-DMAYSQANVRDIVAYAKTHGVQVIPEVDAPAHAGAGWQWGPDYDVGELTLC---WA--NNPLAYNEC----YEAPCGQ----LNPMNEHVYGLLDKVWVE------MAD-------MFE-SDVLHMGGDEVFTKCWKRS---PVVSDAVANTT----DDAEYFEISAKFQERVQT-NLWK----HAP-------SRKVMLWSSELTSSLYS-KYL--PKDKIIVHTWAG----IQNGNEPRHMADAGYQYVASFQDRHYLDCGHNG---IDRKDN-------------------------GWC-APYKTW----QVIYEQVLNP---NITED-LMPLALGGELVLWTEVSGEA-SMDVRIWPRAAALAERAW Aphanomyces_invadans PAFPHRGITLDTSRNFYSIGAIKRVLDGMGMNKLNTFHWHVTDTNSFPIEIIGEPRLTAYGAYS-----A-RQVYTQADIRELVQYAKVRGIRVIPELDAPAHVGAGWQWGPDAGLGDLVVC---FD--HLPW-QAAC----VQPPCGQ----LNPMNPEVYSILDTVYAE------FAT-------LFD-ADVLHMGGDEVHVGCWNMT---DAITQGMPSR-----ESTDFVNVWGQFQVKAAQ-LAMA----HAT-------NRKIMLWTSDLTHTSVIQRYL--PPGQYVIQNWDA----TTTNSTAT-IAALGYHVVLSNYDKWYLDCGHGN---WLTNGT-------------------------SWC-DPLKSW----QVLYDVDMHA---DLPPE-LHQFVLGGEAALWSELADEH-SAEVKLWPRSAASAERLW Apis_mellifera_Hex1 ARLPHRGLLLDTSRHYLPIHDILLTLDAMSYNKMNVLHWHIVDDNSFPYQSSSYPNLSAKGAYH-----P-SMVYTLNDIQQIVDYARLRGIRVMPEFDTPGHTRS-WGLAY---PELLTTC----------YDVKGK----PNGKLGP----MNPTNPALYEFLRNLFAE------IVQ-------VFP-DQYVHLGGDEVPFDCWKSN---PEINSYMKSRN----M-SSYNLLESEYIGRLLR-ITDS----L---------EANTIVWQEVFENGVVM-------PNTTVVHVWTG----LWAKKLEE-ATKAGHPVLLSAC--WYLD--------HIVNPR-------------------------DWK-KFYACD----PLAFNKTVN----------SSHLMLGGEACMWGEFVDKN-NVHPKIWPHASATAERLW Apis_mellifera_Hex2 PTFPYRGLLIDTGRQFFPVERLKRVIDGMAASKLNTFHWHISDSQSFPFDSAQFPEMARWGAYS-----G-DQIYTPDDVKDLADYARIRGVRVLVEIDSPAHAGAGWQWGTEYGYGELALC---VD--QQPW-SSYC----GEPNCGQ----LNPINEHTYRILEGLYKE------LLE-------LTGIRDVVHLGGDEVNLDCWAQY---GNITAAMQAQN----M-TDHHAMWAEFETKMLHRLVKANRDET---------PKAVILWSSPLTKRPYITTYF--DPKIHVIQSWGG----SNWPETPD-LLEDGFRVILSHVDTWYLDCGFGR---WRETGE-------------------------AAC-GEYRTW----QTVYNHRPWR---DYPQQ-HWGLVLGGEAAIWSEQTGDA-SLGPRLWPRASALAERLW Arabidopsis_thaliana_Hex_2 PRFSYRGLLIDTSRHYLPLPVIKNVIDSMTYAKLNVLHWHIVDTQSFPLEIPSYPKLWN-GAYS-----S-SQRYTFEDAAEIVNYARRRGIHVLAEIDVPGHALS-WGKGY---PAL--------------WPSKNC----QEP--------LDVSSDFTFKVIDGILSD------FSK-------IFK-FKFVHLGGDEVNTTCWSAT---PRIAQWLKKHR----M--SEKEAYQYFVLRAQK-IALS----H---------GYEIINWEETFINFGSKL------NRKTVVHNW------LNTGLVEN-VTASGLRCIVSNQEFWYLD--------HIDA---------------------------PWQ-GFYANE----PFQNITDKK----------QQSLVLGGEVCMWGEHIDAS-DIEQTIWPRAAAAAERLW Arabidopsis_thaliana_Hex1 PLFGHRGVLLDTSRNYYGVDDIMRTIKAMSANKLNVFHWHITDSQSFPLVLPSEPSLAAKGSLG-----P-DMVYTPEDVSKIVQYGFEHGVRVLPEIDTPGHTGS-WGEAY---PEIVTCANMFWWPAGKSWEERLA----SEPGTGQ----LNPLSPKTYEVVKNVIQD------IVN-------QFP-ESFFHGGGDEVIPGCWKTD---PAINSFLSSGG-------TLSQLLEKYINSTLPYIVSQ--------------NRTVVYWEDVLLDAQIKADPSVLPKEHTILQTWN-----NGPENTKR-IVAAGYRVIVSSSEFYYLDCGHGG---FLGNDSIYDQ---------------KESGGGSWC-APFKTW----QSIYNYDIAD--GLLNEE-ERKLVLGGEVALWSEQADST-VLDSRLWPRASALAESLW Arabidopsis_thaliana_Hex3 PRFGYRGLLIDTSRHYLPIDVIKQIIESMSFAKLNVLHWHIVDEQSFPLETPTYPNLWK-GAYS-----R-WERYTVEDASEIVRFAKMRGINVMAEVDVPGHAES-WGTGY---PDL--------------WPSLSC----REP--------LDVTKNFTFDVISGILAD------MRK-------IFP-FELFHLGGDEVNTDCWKNT---THVKERLQGRN----F--TTKDAYKYFVLRAQQ-IAIS----K---------NWTPVNWEETFSSFGKDL------DPRTVIQNW------LVSDICQK-AVAKGFRCIFSNQGYWYLD--------HLDV---------------------------PWE-EVYNTE----PLNGIEDPS----------LQKLVIGGEVCMWGETADTS-VVLQTIWPRAAAAAERMW Aspergillus_nidulans PLYPYRGLMVDTGRNFISVRKLHEQLDGMALSKLNVLHWHLDDTQSWPVHIDAYPEMTK-DAYS-----A-RETYSHDDLRNVVAYARARGIRVIPEIDMPAHSASGWQQVD---PDIVACANSWWS--NDNWPLHTA----VQPNPGQ----LDIINPKTYEVVQDVYEE------LSS-------IFT-DDWFHVGGDEIQPNCYNFS---TYVTEWFQED-----PSRTYNDLMQHWVDKAVP-IFRS----VSD-------SRRLVMWEDVVLNTEHADDV----PTDIVMQSWN-----NGLENINK-LTERGYDVIVSSADFMYLDCGRGG---YVTNDDRYNE-QTNPDPD--TPSFNYGGIGGSWC-GPYKTW----QRIYNYDFTL---NLTNA-QAKHVIGATAPLWSEQVDDV-NISNLFWPRAAALAELVW Aspergillus_oryzae PLYPYRGIMLDTGRNFVSLPKIFEQLEGMSLSKLNVLHWHIDDAQSWPIWVDVYPEMVK-DAYS-----P-HEIYSRNDVRNIVNYARARGIRVIPEIDMPSHSSSGWKQVD---PEMVTCTDSWWS--NDDWPLHTA----VEPNPGQ----LDIIYNKTYEVVGNVYKE------LSD-------IFP-DHWFHVGGDEIQPNCFNFS---THVTKWFAED-----PSRTYHDLAQYWVDHAVP-IFQN----YSQ-------ERRLVMWEDIALSADNAHDV----PKNIVMQSWN-----NGLEYISN-LTARGYDVIVSSSDFLYLDCGHGG---FVTNDPRYNV-MANPDAN--TPNFNYGGNGGSWC-APYKTW----QRIYDYDFTL---NLTET-QAKHIIGATAPLWGEQVDDI-NVSSMFWPRAAALAELVW Beauveria_bassiana PKFPHRGMVLDVSRHWFAVEDIKHTIDALAMTKMNVLHLHMTDTQSWPLEIPALPLLAERHAYS-----K-GLTYSPAVIADLHEYGVHRGVQVIVEIDMPGHVG--IEHAY---PGLSVAY----N--ERPY-TQYC----AQPPCGS----LRLGNTKVEEFLDKLFEDL-----LPR-------LSPYTAYFHTGGDEYKANNSLLD---PDLKTN---------DVSILQPLLQRFLDHAHKKIRDF--------------GLVPMVWEEMINEWNATL------GKDVVVQSW------LAQDGIKK-LAESGHKVVVSSSDAYYLDCGRGQ---FIDYEN--------------GPAFQRAYPFTDWC-APTKNW----RLIYAQDPRA---GISGD-AAANVLGGEVAVWTETIDAT-SLDTIVWPRAAAAGESLW Beauveria_bassiana_KGQ03395_ PKFPHRGMVLDVSRHWFAVEDIKHTIDALAMTKMNVLHLHMTDTQSWPLEIPALPLLAERHAYS-----K-GLTYSPATIADLHEYGVHRGVQVIVEIDMPGHVG--IEHAY---PGLSVAY----N--ERPY-TQYC----AQPPCGS----LRLGNTKVEEFLDKLFEDL-----LPR-------LSPYTAYFHTGGDEYKANNSLLD---PDLKTN---------DVSILQPLLQRFLDHAHKKIRDF--------------GLVPMVWEEMINEWNATL------GKDVVVQSW------LGQDGIKK-LAESGHKVVVSSSDAYYLDCGRGQ---FIDYEN--------------GPAFQRAYPFTDWC-APTKNW----RLIYAQDPRA---GISGD-AAANVLGGEVAVWTETIDAT-SLDTIVWPRAAAAGESLW Blastocystis_hominis PRFPHRGILMDTSRHFESLPSIKKLIDSMTYAKLNVLHWHITDSQANPAQSQAFPKWWE-GSYT-----P-QERYSTMDFEEIVEYARMRGVRVVPEMDVPGHEAS-WCKGY---PEVCP--------------SETC----LEP--------LDPTSDKTWELIQGVLDEWSGKEQGKG-------IFF-DNYFHMGGDEVDTSCWKTT---VHIIEWMKKNN----L--TDHDTYKYFVQKVQQ-MVLK----N---------HRNGIYWEEVWLNFRTQL------DKETIIQTW------MNKKTMKD-VVANGYKVIISDPHT-YLD--------HLDE---------------------------TWK-ALYNDE----PFEFTDVPE----------EQALVLGGEACMWAETVDVS-DLYNTVWPRAGAFAERYW Bombyx_mori_Hex1 PVYPYRGILLDTARNFYSIDSIKRTIDAMAAVKLNTFHWHITDSQSFPLVLQKRPNLSKLGAYS-----P-TKVYTKQDIREVVEYGLERGVRVLPEFDAPAHVGEGWQDTG------LTVC---FK--AEPW-TKFC----VEPPCGQ----LNPTKEELYDYLEDIYVE------MAE-------AFESTDMFHMGGDEVSERCWNSS---EEIQNFMIQNRWNL-DKSSFLKLWNYFQKNAQDRAYKA----FGK-------RLPLILWTSTLTDYTHVEKFL--DKDEYIIQVWTT----GADPQIQG-LLQKGYRLIMSNYDALYFDCGFGA---WVGSGN-------------------------NWC-SPYIGG----QKVYGNSPAV----MALS-YRDQILGGEVALWSEQSDPA-TLDGRLWPRAAAFAERMW Bombyx_mori_Hex2 PRYAHRGLLVDTSRHYISMSNILLILDAMAMNKMNVFHWHIVDDQSFPYQSERFPDLSRLGAYH-----E-TLIYTKENIQTVIDHARNRGIRVIPEFDVPGHTRS-WGVAK---PDLLTHC----------YDQDGD----YVG-LGP----MNPIKDSTYTFLQELFHE------VQA-------LFP-ERYIHIGGDEVDLDCWESN---PEFQRYIQEHN----L-TSVADFHALFMRNTIP-LLSE--------------NSRPIVWQEVFDEGVPL-------PKDTIVQVWKE----NEAPEMLN-ILRASHQLIYSTG--WYLD--------HLNTGG-------------------------DWT-EFFNKD----PRDLVNGLSK-------DINVDNIVGGEACMWAEVVNDM-NIMSRVWPRASAVAERLW Candida_albicans PNFKHRGLMIDSGRNFLTVDSILEQIDIMALSKMNSLHWHLADSQSWPVALESYPHMIK-DAYS-----N-DEVYSKNDLKYIVDYARARGVRVIPEIDMPGHARAGWKQVD---PTIVECA-------DAFW-TDAA----VEPPPGQ----LNIESEKTYEVISNVYNE------LSD-------IFI-DDVFHVGNDELQEKCYSAQ---------LSPNN-------TVTDLLKRYLKKALP-IFNK----VN--------HRKLTMWDDVLLSDVSADKI----PSNITLQVW------HEISGVKN-LTSRGYDVVVSSSDFLYLDCGNAG---WVTNDPRY---VETPE----NVDFN-TGQGGSWC-GPYKSY----QRIYNFDFTA---NLTET-EKNHVLGREAALWSEQVDST-VLTTKIWPRTAALAELTW Capsaspora_owczarzaki PRFSHRGLLVDTSRHFEPVPTLKAVIESMSFAKLNVFHWHIVDTQSFPFESRTYPDLWD-GTFS-----L-NERYTQEDVMEIVEYAKLFGIRVMPEFDGPGHAAS-WCTGY---PGICP--------------SPSC----LEP--------LDPSSPLTFQVIDGLLSETSGNSRYAG-------LFP-DDMIHFGGDEVDPTCWTQT---PRIVNWMNSKN----Y--TTDDAYMYFIETVHS-MAIK----R---------GRNPVNWEEVFLHFGSSL------DNDTIVHIW------LNHDTLAQ-VVAAGYRGILSNQDVWYLD--------HLGT---------------------------TWQ-QFYLNE----PHEGIDDPN----------QQKLVLGGEVCMWGETVDTS-DIFNTVWPRAAAAAERLW Choristoneura_fumiferana PVYPYRGILLDTARNYYTIDSIKKTIDAMAAVKLNTFHWHITDSQSFPFVSERRPNLSKYGAYT-----P-AKIYTKAAIRDVVQFGLERGVRVLPEFDAPAHVGEGWQDTG------LTVC---FK--AEPW-ASYC----VEPPCGQ----LNPTKDELYDVLEDIYTD------MAE-------VFK-PDIFHMGGDEVSERCWNAS---DDIQQFMMQHRWDL-DKSSFLNLWDYFQRKAQEKVYKA----FGK-------KVPIILWTSTLTDHVYVDKYL--NKDDYIIQVWTT----GVDPQILG-LLQKGYRLIMSNYDALYLDCGFGA---WVGSGN-------------------------NWC-SPYIGW----QKVYDNSPAV----MALD-YKDQVLGGEAALWSEQSDSP-TLDDRLWPRAAALAERLW Coccidiodes_posadasii PLYPVRGIMIDTARNFISVKKIFEQLDGMALSKLNVLHWHITDTQSWPVEVRSYPQMTE-DAYS-----R-RETYGPSDIRKVIEYARARGIRVVPEIDMPGHSASGWRKID---PDIVACADSWWS--NDDWEKHTA----VQPNPGQ----LDIANNKTYKVVEKVYND------ISR-------IFT-DDWFHVGGDELQPNCFLTS---KIVRDWLKQGS------RTFNDLLQHWVDKTVP-MMKK----VKK-------NRRLLMWEDVLLSGNMHAHRV---PRDIIMQSWN-----GGLANIKK-LTARGYEVIVSSADFLYLDCGYGG---WVGNDPRYNV-MENPDPE--TPNFNYGGNGGSWC-GPYKTW----QRIYNYDFTD---GLNYA-EKKRVIGAIAPLWSEQADDV-VISNKMWPRAAALAELVW Cordyceps_bassiana PNYPYRGVMVDSGRNFISVQKLQEQIDGLALSKMNILHWHITDAQSWPIHLDALPDFTK-DAYS-----E-REIYSAQNVKDLIAYARARGVRVVPEIDMPGHSALGWQQYD---NDIVTCQNSWWS--NDNWPLHTA----VQPNPGQ----LDVLNPKTYQAVEKVYAE------LSQ-------RFS-DDFFHVGGDELQVGCFNFS---KTIRDWFAADS----S-RTYFDLNQHWVNTAMP-IFTS----KNITGNK---DRRIVMWEDVVLSPDAAAKNV---SKNVIMQSWN-----NGITNIGK-LTAAGYDVIVSSADFLYLDCGFGG---YVTNDARYNV-QENPDPTAATPSFNYGGNGGSWC-APYKTW----QRIYDYDFAK---NLTAA-QAKHIIGASAPLWSEQVDDT-IISGKMWPRAAALGELVW Danio_rerio_Hex1 PRFAFRGLLLDTSRHYLPLHAILKTLDAMAYSKFNVFHWHIVDDPSFPYQSRTFPDLSKKGAFH-----PFTHIYTQSDVMRVIEHARMRGIRVVPEFDSPGHTQS-WGKGQ---PDLLTPC----------Y-KGGK----PSGTYGP----VDPTVDTTYRFMERLLKE------VKF-------VFP-DSYVHLGGDEVSFACWQSN---PSVGKFMEKMG----FGRDFTKLESFYMESIMN-ITAA----L---------NKTSIVWQDVFDYHERI-------PQGTVLEIWKGE---TYQTELSK-MTKAGHRVLLSAP--WYIN--------HITYGQ-------------------------DWR-NSYAVQ----PQNFSGTEE----------QKKLVIGGEVAMWGEYVDAT-NLNPRLWPRACAAAERLW Danio_rerio_Hex2 PRFAHRGILLDSSRHFLPLKVILANLEAMAMNKFNVFHWHIVDDPSFPFMSRTFPELSQKGAYH-----PFTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQS-WGNGI---KDLLTPC----------Y-SGSS----PSGSFGP----VNPILNSSYEFMAQLFKE------IST-------VFP-DAYIHLGGDEVDFSCWKSN---PDIQKFMNQQG----FGTDYSKLESFYIQRLLD-IVAA----T---------KKGYMVWQEVFDNGVKL-------KDDTVVEVWKGN---DMKEELQN-VTGAGFTTILSAP--WYLD--------YISYGQ-------------------------DWQ-RYYKVE----PLDFTGTDA----------QKKLVIGGEACLWGEYVDAT-NLTPRLWPRASAVAERLW Dictyostelium_discoideum PRYPWRGFMVDSARHYIPKNMILHMIDSLGFSKFNTLHWHMVDAVAFPVESTTYPDLTK-GAFS-----P-SATFSHDDIQEVVAYAKTYGIRVIPEFDIPGHAAA-WGIGY---PELVATC------------PDYA----ANVNNIP----LDISNPATFTFIQNLFTE------IAP-------LFI-DNYFHTGGDELVTGCWLED---PAIANWMTKMG----F--STTDAFQYFENNLDV-TMKS----I---------NRTKITWNDPIDYGVQL-------NPETLVQVW------SSGSDLQG-IVNSGYKALVSFA--WYLDKQNPDNNIHYEWQD-------------------------TWQ-DFYAAD----PTNNIST------------NAENIIGGEATMWAEQINQV-NWDVRVWPRAIGIAERLW Drosophila_melanogaster_Hex1 PVYKWRGLLLDTSRNYYSVKSIKRTLEGMALVKLNTFHWHITDSHSFPLEVKKRPELHKLGAYS-----Q-RQVYTRRDVAEVVEYGRVRGIRVMPEFDAPAHVGEGWQHKN------MTAC---FN--AQPW-KSFC----VEPPCGQ----LDPTVNEMYDVLEDIYGT------MFD-------QFN-PDIFHMGGDEVSTSCWNSS---QPIQQWMKKQGWGL-ETADFMRLWGHFQTEALGRVDKV----ANGT------HTPIILWTSGLTEEPFIDEYL--NPERYIIQIWTT----GVDPKVKK-ILERGYKIIVSNYDALYLDCGGAG---WVTDGN-------------------------NWC-SPYIGW----QKVYDNSLKS----IAGD-YEHHVLGAEGAIWSEQIDEH-TLDNRFWPRASALAERLW Drosophila_melanogaster_Hex2 PAFSHRGVLLDTARNFVPLKFIRSTLDAMAASKLNVLHWHVVDTHSFPLEITRVPEMQRYGAYS-----S-SQTYSRQDALNLVKYARLRGIRILIEIDGPSHAGNGWQWGPAAGLGNMSVC---LN--QSPW-RRFC----VQPPCGQ----LNPLNDHMYAVLKEIFED------VAE-------VGAPEETLHMGGDEVFLPCWNNT---DEIRDGMRARGYDL-SEQSFLRLWSQFHQRNLNAWDEI----NERMYPGIKEPKSVIIWSSHLTNPRYIETYL--PKERFIIQTWVE----SQDALNRE-LLQRGYRLIVSTKNAWYLDHGF-------------------------------------WGSTSYYNW----RTVYSSGMPV------GR-SKDQVLGGEVCMWSEYVDQN-SLESRIWPRAGAAAERMW Drosophila_melanogaster_Hex3 PKFRYRGLMLDTSRHFFSVESIKRTIVGMGLAKMNRFHWHLTDAQSFPYISRYYPELAVHGAYS-----E-SETYSEQDVREVAEFAKIYGVQVIPEIDAPAHAGNGWDWGPKRGMGELAMC---IN--QQPW-SFYC----GEPPCGQ----LNPKNNYTYLILQRIYEE------LLQ-------HTGPTDFFHLGGDEVNLDCWAQY--------F---------NDTDLRGLWCDFMLQAMARLKLANNGVA---------PKHVAVWSSALTNTKRLP------NSQFTVQVWGG----STWQENYD-LLDNGYNVIFSHVDAWYLDCGFGS---WRATGD-------------------------AAC-AQYRTW----QNVYKHRPWE-RMRLDKK-RKKQVLGGEVCMWTEQVDEN-QLDNRLWPRTAALAERLW Drosophila_pseudoobscura_Hex1 PKFKWRGLLLDTSRNYYSVKAIKRTLDGMALVKLNTFHWHITDSHSFPLELRKRPELYKLGAYS-----P-RQVYSQRTVADIVEYGRVRGVRVMPEFDAPAHVGEGWQHKN------MTAC---FN--AQPW-KDFC----VEPPCGQ----LDPTAEGLYDVLEDIYAE------MWE-------LFS-PDIFHMGGDEVSTSCWNSS---LPIRQWMKDQGWGL-ETADFMRLWGHFQTEALKRVDIV----ANGS------QTPIILWTSHLTEEPFIDEYL--NPERYIIQIWTT----GGDPHVKK-ILERGFKTIVSNYDALYLDCGGAG---WVSDGN-------------------------NWC-SPYIGW----QKVYDNSMSA----IAGD-YEHHVLGAEAAIWSEQIDEH-TLDNRFWPRASALAERLW Drosophila_pseudoobscura_Hex2 PAFPHRGVLLDTSRNFIPLRYLRSTLDAMAASKMNVLHWHVVDTHSFPLEITRVPEMQRYGAYS-----A-SQTYSRTDSVNLVKYARLRGIRILIEIDGPSHAGNGWQWGPAAGLGNMSVC---LN--QSPW-RRFC----VQPPCGQ----LNPLNDHMYAVLKEILED------VAE-------VGAPEETVHMGGDEVFLPCWNNT---EEIVTKMRAQGYDL-SEQSFLRLWSQFHQRNLNAWDDI----NERMYPSIKEPKPVILWSSHLTVPKYIETFL--PKERFIIQTWVD----SQDPLNRD-LLQRGYRLIVSTKNAWYLDHGF-------------------------------------WGSTSYYNW----RTVYASGMPM------GN-HGNQVLGGEVCMWSEFVDHN-SLESRIWPRAGAAAERLW Drosophila_pseudoobscura_Hex3 PKFRYRGLMLDTSRHFFSVEAIKRTIVGMGLSKLNRFHWHLTDAQSFPYISRNYPELAEHGAYS-----E-GETYTEQDVREVADFAKIHGVQVIPEIDAPAHAGNGWDWGPKRGMGELAVC---IN--QQPW-SFYC----GEPPCGQ----LNPKNNHTYLILQRLYEE------LLQ-------ATGPTDLFHLGGDEVNLDCWAQY--------F---------NDTDLRGLWCDFMLQAMA-RLKL----ANNGVA----PKYLAVWSSALTNTKCLP------NSQFTVQVWGG----STWQENYD-LLDNGYNVIFSHVDAWYLDCGFGS---WRSTGE-------------------------AAC-SPYRTW----QNVYKHRPWE-RMRLDKK-RRKQVLGGEACLWTEQVDEN-QLDNRLWPRAGALGERLW Entamoeba_histolytica_Hex1 PRFKWRGLMVDPSRNPLSPLMFKRIIDTLASVKANVLHIHLSDAQTFVFESKKYPLLHQKGMYD-----E-SFVLTQSFLRELAQYGANRGVIVYGEIDTPAHTAS-WNLGY---PGVVANC----------WDYIVS----TSMRYGENVLSLNPANPNTFPIIDALMKE------LSD-------TFG-TDYVHVGGDEVWTSGWSKSKEYSDIQKFMKSKG----L-NSLTELEGYFNKYAQEQVIHN--------------GKHPVVWEEVFKKGNA--------DKNTIIQVW------DDIRLLQQ-VVNSGYKAIFSAG--FYLDKQMPL---CNSYDS-------------------------STCVNTHSMWVWTNRDMYDNDPVK---SLSSS-EKENVLGGEGCSWGESTDEQ-NFFDRVFQRYSAIAERLW Entamoeba_histolytica_Hex2 PRLQWRGLMIDVARNSFSRSAFVKIINAMAAIKANVLHIHLSDAQTFMFESKEYPELSKKGAFF-----Q-NKVLTQSFIKQLVQYGAKRGVIVYPEIDTPAHTAS-WNAGY---PGVVADI----------WDYIVS----SSMRYGENVLALNPANEKTFSIIDALMKE------MGE-------VFG-NDYVHFGGDEVWTGAWSKAKEYPAILEWMNKKG----I-NTLKELEAYFNKYAQEQIIKN--------------GKTPVCWEEVYQKGSA--------DKKTIIQVW------NNVNLLKE-AATAGYKVILSAG--YYLDMQMPL---CSDYVA-------------------------DSCTNPNHMWVWTNRDMYRNDPIK---ELDYA-TKQNVLGGEACSWDESVDEQ-NFFDRVFQRFSAVAERFW Fenneropenaeus_chinensis PTFPYRGTLLDTSRNFFSVKSIERTLDAMAANKLNTFHWHITDSHFFPMQLETLPNMAYYGAYG-----S-RFIYSTADIRNLVEYGRIRGIRVLAEFDAPAHVGNGWRWGEGQGLGKLAVC---VN--REPW-QSYC----VEPPCGQ----LNLANPNMYDVLGQIYNE------MVE-------LFSPIDLFHYGGDEVNLNCWNTT---DEITSWMDENNFGR-DDDAYYNQWSIFQEKSRQ-LPTTANGGN---------EVPGILWTSHLTEEGRADQYL--DPTKYIIQIWTT----GTDKLIGE-LLEKNFRVIFSNYDHWYLDCGFGA---WVGEGN-------------------------NWC-SPYKGW----QAVYDNSPLDIATDLTGSAHEDLILGGEAALWTEQADEM-VLDARLWPRGAALAERLW Homo_sapiens_Hex1 PRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYN-----PVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLS-WGPGI---PGLLTPC----------Y-SGSE----PSGTFGP----VNPSLNNTYEFMSTFFLE------VSS-------VFP-DFYLHLGGDEVDFTCWKSN---PEIQDFMRKKG----FGEDFKQLESFYIQTLLD-IVSS----Y---------GKGYVVWQEVFDNKVKI-------QPDTIIQVWREDIPVNYMKELEL-VTKAGFRALLSAP--WYLN--------RISYGP-------------------------DWK-DFYVVE----PLAFEGTPE----------QKALVIGGEACMWGEYVDNT-NLVPRLWPRAGAVAERLW Homo_sapiens_Hex2 PRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYS-----L-SHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLS-WGKGQ---KDLLTPC----------Y-SRQN----KLDSFGP----INPTLNTTYSFLTTFFKE------ISE-------VFP-DQFIHLGGDEVEFKCWESN---PKIQDFMRQKG----FGTDFKKLESFYIQKVLD-IIAT----I---------NKGSIVWQEVFDDKAKL-------APGTIVEVWKDS---AYPEELSR-VTASGFPVILSAP--WYLD--------LISYGQ-------------------------DWR-KYYKVE----PLDFGGTQK----------QKQLFIGGEACLWGEYVDAT-NLTPRLWPRASAVGERLW Lagenidium_giganteum PRFAHRGLLIDTSRHFLAIPTILRALDSMAFAKLNVLHWHLSDEESFPLQSFSHPNLWN-SAYS-----P-VERYTQNELAFVVEYARVRGIRVMFELDVPGHAAS-WCVGE---PSVCPST--------------TC----RTP--------LNVANNYTFQVIQDVLEE------VTGGGIRAQGLFP-YDLLHLGGDEVDTRCWDSV---PSVSQWLQDQQ----F--SANDAYKYFVDRANA-IARQ----L---------QRRPVMWVEVFEQFRDKL------HPSTIVHVW------KDKQSLAE-VLAAGYHALLSNQHDWYLD--------HLAT---------------------------SWQ-NIYQNE----PFDGIDDEE----------QQARVLGGEAAMWGETVDGS-DFENTVWPRLAAFAERMW Magnaporthe_grisea PLYPHRGILFDTARQWYPVVNLLRTIDAMAWNKMNRLHVHVTDSQSWPLDLPSMPEVAREGAHR-----R-DLIYTADDIRRVQEYGVHRGVQVYFEIDMPGHIGS-LYHSH---PELIVAY----N--EQPY-YHYC----AQPPCGA----FKLNDSRVDAFLEKLFDDV-----LPR-------VHPYAAYFHTGGDELNANDSMLD---ENIRSN---------KSEVLQPLLQKFIDKQHERVRSH--------------DLTPMVWEEIPLDWNVTL------GKDVPVQSW--------LGNAQK-LAAAGHQVIDSNYNFWYLDCGRGQ---WINMEN--------------GAAYRQFYPFNDWC-GPTKSW----QLVYSYDPRA---GLSEE-AAKLVLGGEVAIWSETIDEQ-TIDSIIWPRANAAGEVLW Manduca_sexta PVYPYRGILLDTARNYYTIDAIKKTIDAMASAKLNTFHWHITDSQSFPFVMDKRPNLVKYGAYS-----P-SKVYTKKAIREVVEYALERGVRCLPEFDAPAHVGEGWQESD------LTVC---FK--AEPW-AKYC----VEPPCGQ----LNPIKDELYDVLEDIYVE------MAE-------AFHSTDMFHMGGDEVSDACWNSS---EEIQQFMIQNRWDL-DKSSFLKLWNYFQTKAEDRAYKA----FGK-------NIPLVMWTSTLTDYTHVDKFL--DKEKYIIQVWTT----GVDPQIQG-LLQKGYKLIISNYDALYFDCGFGA---WVGSGN-------------------------NWC-SPYIGW----QKVYDNSPAV----MALS-YRDQILGGEVALWSEQADSS-TLDGRLWPRAAAFAERVW Metarhizium_anisopliae PNYPYRGVMVDTGRNFISANKIKEQIDGLALSKMNILHWHITDTQSWPIHLEAYPQVTK-DAYS-----G-RESYSVKDVQDIISYARARGVRVIPEIDMPGHSASGWQQID---KDIVTCQNSWWS--NDNWPLHTA----VQPNPGQ----LDVMNPKTYQVVGNVYSE------LSK-------KFS-DDFFHVGGDELQIGCFNFS---KGIRDWFAADP----K-RTYFDLNQYWIDHAYP-LFMS----EENSGKK---DRRLIMWEDVVLSPDAHAHNV---SKSVIMQSWN-----NGVANIDK-LTKAGYDVIVSSADFMYLDCGNGG---YVTNDPRYNAPQSNPDATGATFSFNYGGPGGSWC-APYKTW----QRIYDYDFTA---NLTSD-QAKHIIGAAAPLWSEQVDDA-VISSKMWPRAAALAELVW Mus_musculus PRFPHRGILIDTSRHFLPVKTILKTLDAMAFNKFNVLHWHIVDDQSFPYQSTTFPELSNKGSYS-----L-SHVYTPNDVRMVLEYARLRGIRVIPEFDTPGHTQS-WGKGQ---KNLLTPC----------YNQKT-----KTQVFGP----VDPTVNTTYAFFNTFFKE------ISS-------VFP-DQFIHLGGDEVEFQCWASN---PNIQGFMKRKG----FGSDFRRLESFYIKKILE-IISS----L---------KKNSIVWQEVFDDKVEL-------QPGTVVEVWKSE---HYSYELKQ-VTGSGFPAILSAP--WYLD--------LISYGQ-------------------------DWK-NYYKVE----PLNFEGSEK----------QKQLVIGGEACLWGEFVDAT-NLTPRLWPRASAVGERLW Mus_musculus_Hex2 PRFPHRGVLLDTSRHYLPLSSILDTLDVMAYNKFNVFHWHLVDDSSFPYESFTFPELTRKGSFN-----PVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLS-WGPGA---PGLLTPC----------Y-SGSH----LSGTFGP----VNPSLNSTYDFMSTLFLE------ISS-------VFP-DFYLHLGGDEVDFTCWKSN---PNIQAFMKKKG----F-TDFKQLESFYIQTLLD-IVSD----Y---------DKGYVVWQEVFDNKVKV-------RPDTIIQVWREEMPVEYMLEMQD-ITRAGFRALLSAP--WYLN--------RVKYGP-------------------------DWK-DMYKVE----PLAFHGTPE----------QKALVIGGEACMWGEYVDST-NLVPRLWPRAGAVAERLW Neotyphodium_sp. PKYPYRGVMVDTGRNFISVSKIKEQIDGLALSKMNILHWHITDTQSWPIQLKSYPEVTK-DAYS-----S-KESYSEQDVQDVISYARARGVRVIPEIDMPGHSASGWRQID---RDIVTCENSWWS--NDDWPHHTA----VQPNPGQ----LDVMNPKTYKVVKKIYSE------LSK-------RFA-DNFFHVGGDELQVGCFNFS---KGIRDWFAADP----K-RTYFDLNQHWVDKSYP-LFMS----EQNTGKK---DRRLIMWEDVVLSADASASKV---SKEVIMQSWN-----NGVGNIAK-LTKAGYDVIVSSADFMYLDCGFGG---YVTNDPRYNSPQSNPDPTGTAFSFNYGGPGGSWC-APYKTW----QRIYDYDFTA---NLTDA-QAKHIIGAAAPLWSEQVDDT-IISGKMWPRAAALAELVW Oriza_sativa_Hex1 PLYPHRGLMLDTGRTYFPVADILRTIDAMAANKMNVFHWHITDSQSFPLELPSEPALAEKGSYG-----D-GMRYTVDDVKLIVDFAMNRGVRVVPEIDTPGHTAS-WAGAY---PELVSCAGEFWLPDASDWPSRLA----AEPGAGQ----LNPLEPKTYQVMSNVIND------VTS-------LFP-DGFYHAGADEVTPGCWNAD---PSIQRYLARGG-------TLSRLLEKFVGAAHPLIVSR--------------NRTAVYWEDVLLDQAVNVTASAIPPETTILQTWN-----NGGNNTRL-IVRAGYRAIVSSASFYYLDCGHGD---FAGNDSAYD--DPRSD---------YGTSGGSWC-GPYKTW----QRVYDYDVAG---GLTAE-EARLVVGGEVAMWTEQVDAA-VLDGRVWPRASAMAEALW Oriza_sativa_Hex4 PHFTHRGILLDTARNFYPVRDILHTLRAMAFNKLNVFHWHITDAQSFPIVLPTVPNLANSGSYS-----P-TMRYTENDVRHIVSFAASFGIRVIPEIDMPGHTGS-WAGAY---PEIVTCA-------NRFWAPHAEPALAAEPGTGQ----LNPLNPKTYRVAQDVLRD------MVA-------LFP-DPYLHGGADEVNTACWEDD---PVVRRFLAEGG-------THDHLLELFINATRPFVAQE----L---------NRTVVYWEDVLLGPKVTVGPTILPRETTILQTWN-----DGPENTKR-VVAAGYRAIVSSASYYYLDCGHGG---WVGNDSRYD--KQEKEREGTPLFNDPGGTGGSWC-APFKTW----QRVYDYDILH---GLTDD-EAQLVLGGEVALWSEQSDET-VLDARLWPRAAAAAETLW Oryza_sativa_Hex2 PRFAFRGLLLDTSRHFLPVDVIKQVIDSMSFSKLNVLHWHIIDEQSFPLEVPSYPKLWK-GSYS-----K-LERYTVEDARDIVSYARKRGIHVMAEIDVPGHAES-WGKGY---PKL--------------WPSPKC----REP--------LDVTSNFTFEVISGILSD------MRK-------IFP-FGLFHLGGDEVYTGCWNAT---PHVKQWLHERN----M--TTKDAYKYFVLKAQE-IAIN----L---------NWIPVNWEETFNSFKENL------NPLTVVHNW------LGPGVCPK-VVEKGFRCIMSNQGVWYLD--------HLDV---------------------------PWQ-DFYTSE----PLAGINNTA----------QQKLVLGGEVCMWGETADTS-DVQQTIWPRAAAAAERMW Oryza_sativa_Hex3 PRFPYRGLLIDTSRHYLPVTVIKKVIDTMAYSKLNVLHWHIVDAQSFPIEIPSYPKLWN-GSYS-----F-SERYTTSDAVDIVRYAENRGVNVMAEIDVPGHALS-WGVGY---PSL--------------WPSDSC----KEP--------LDVSNNFTFGVIDGILSD------FSK-------VFK-FKFVHLGGDEVNTSCWTAT---PHIKKWLDDNQ----M--NVSDAYRYFVLRSQK-LAIS----H---------GYDVINWEETFNNFGDKL------DRRTVVHNW------LGEDVAPK-VVAAGLRCIVSNQDKWYLD--------HLDA---------------------------TWE-GFYTNE----PLKGIDDPE----------QQSLVIGGEVCMWGEQIDAS-DIEQTIWPRAAAAAERLW Oryza_sativa_Hex5 PRFPYRGLLIDTSRHYLPVPVIKSVIDSMTYSKLNVLHWHIVDEQSFPIEIPSYPKLWN-GAYS-----Y-SERYTMDDAIDIVQYAERRGVNVLAEIDVPGHALS-WGVGY---PSL--------------WPSATC----KEP--------LDVSSESTFQVINGILSD------FSK-------VFK-FKFVHLGGDEVNTSCWTST---PRVKAWLAQHG----M--KESDAYRYFVLRAQK-IAKS----H---------GYEVINWEETFNNFGDKL------DRRTVVHNW------LGGGVAEK-VVAAGLRCIVSNQDKWYLD--------HLEV---------------------------TWD-GFYMNE----PLRNIKNPA----------QQKLVLGGEVCMWAEHIDAS-DIQQTIWPRAAAAAERLW Ostrinia_furnacalis PVYPYRGILLDTARNYYSIESIKRTIEAMAAVKLNTFHWHITDSQSFPFVTTKRPNLYKFGALS-----P-QKVYTKAAIREVVRFGLERGVRVLPEFDAPAHVGEGWQDTD------LTVC---FK--AEPW-KSYC----VEPPCGQ----LNPTKDELYQYLEDIYSD------MAE-------VFDTTDIFHMGGDEVSEACWNSS---DSIQNFMMQNRWDL-DKESFLKLWNYFQQKAQDKAYKA----FGK-------KLPLILWTSTLTNYKHIDDYL--NKDDYIIQVWTT----GVDPQIKG-LLEKGYRLIMSNYDALYFDCGYGA---WVGAGN-------------------------NWC-SPYIGW----QKVYDNSPAV----IALE-HRDQVLGGEAALWSEQSDTS-TLDGRLWPRAAALAERLW Pan_troglodytes_Hex1 PRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYN-----PVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLS-WGPGI---PGLLTPC----------Y-SGSE----PSGTFGP----VNPSLNNTYEFMSTFFLE------VSS-------VFP-DFYLHLGGDEVDFTCWKSN---PEIQDFMRKKG----FGEDFKQLESFYIQTLLD-IVSS----Y---------GKGYVVWQEVFDNKVKI-------QPDTIIQVWREDIPVNYMKELEL-VTKAGFRALLSAP--WYLN--------RISYGP-------------------------DWK-DFYVVE----PLAFEGTPE----------QKALVIGGEACMWGEYVDNT-NLVPRLWPRAGAVAERLW Pan_troglodytes_Hex2 PRFSHRGILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSIAFPELSNKGSYS-----L-SHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLS-WGKGQ---KDLLTPC----------Y-SRQN----KLDSFGP----INPTLNTTYSFLTTFFQE------ISE-------VFP-DQFIHLGGDEVEFKCWESN---PKIQDFMRQKG----FGTDFKKLESFYIQKVLD-IIAT----I---------NKGSIVWQEVFDDKAKL-------APGTIVEVWKDS---AYPEELSR-VTASGFPVILSAP--WYLD--------LISYGQ-------------------------DWR-KYYKVE----PLDFGGTQE----------QKQLFIGGEACLWGEYVDAT-NLTPRLWPRASAVGERLW Phaeodactylum_tricornutum PVYPYRGLMIDTARHFLPLPLILQNLDAMEASKLNVLHWHVTDSQSWPYVSTAFPELSARGAFG-----P-EETYTATDIALVVREAAARAI----------------GRSH---PEWLTPC-------------GSK----PRP-QEP----LDATNPAVYEFVHRLYDE------LAI-------LFAHESFLHVGGDEVNLDCYHNS---TTVQRWMRKHN----M-TQELEVLSYFERDLLSYVTAV----L---------NRRPIVWQELFDSGLGL-------PNQTIVDVWK-----SWEPSSRYNATLRGHEVILSSC--WYLD--------HLNE---------------------------DWQ-SFYACD----PREFNGTKE----------QKNLILGGHASMWGERVDAT-NFLSRVWPRASATAEKLW Rattus_norvegicus_Hex1 PRFPHRGILLDTSRHYLPLSSILNTLDVMAYNKFNVFHWHLVDDSSFPYESFTFPELTRKGSFN-----PVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLS-WGAGV---PGLLTPC----------Y-SGSR----LSGTYGP----VNPSLNSTYDFMSTFFLE------ISS-------VFP-DFYLHLGGDEVDFTCWKSN---PNIQAFMKKKG----F-TDYKQLESFYIQTLLD-IVSD----Y---------DKGYVVWQEVFDNKVKV-------RPDTIIQVWREEMPVQYMKEIEA-ITQAGFRALLSAP--WYLN--------RVKYGP-------------------------DWK-EMYKVE----PLAFRGTPA----------QKALVIGGEACMWGEYVDST-NLVPRLWPRAGAIAERLW Rattus_norvegicus_Hex2 PRFPHRGILIDTSRHYLPVKTIFKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYS-----L-SHVYTPNDIHMVLEYARLRGIRVIPEFDSPGHTQS-WGKGQ---KNLLTPC----------FIQKIR----TQK-VGP----VDPSLNTTYVFFDTFFKE------ISR-------VFP-DQFIHLGGDEVEFECWASN---PNIQNFMKKKG----FGNNFRRLESFYIKKILD-IITS----L---------KKSSIVWQDVFDDQVEL-------QPGTVVEVWKSE---NYLNELAQ-VTASGFPAILSAP--WYLD--------LISYGQ-------------------------DWR-NYYKAE----PLNFEGSEK----------QKQLVIGGEACLWGEYVDAT-NLIPRLWPRASAVGERLW Saprolegnia_diclina PAYSHRGIVLDTSRNYFSIESLRRLIDTMAANKLNTFHWHFSDSGSFPMELTSEPRLTMYGAYS-----R-DQIYTLDQVRELVQFAKSRGVRIIPELDVPSHAGAGWQWGPKAGYGELTLC---YG--SDPW-MNYC----VQPPCGQ----LNPLNAHVYDILKTVFAE------LHS-------IFD-DEVFHMGGDEVSVACWNST---KTITDHIKDTS----TNAPFFELWGDFQLKAGEYVEKA--------------NKKIMVWTSDLTTDSYLKYFK---PKNTIVQLWGA----ATDGDAAR-LTSKGFSVVASYYDTHYLDCGFGG---WVSKGN-------------------------GWC-APYKSW----QVIYDLDVRA---NLTEA-SAKLMLGSEVVMWSEIAGDR-AVEAKIWPRAAALAERLW Saprolegnia_parasitica PAYRHRGVVLDTSRQYYSVAAIRRLLDGMGATKLNTFHWHFTDTASFPVEIKGEPRLTSYGALH-----P-RQIYTQPAIRELVAYAKARGVRVIPEVDAPSHAGAGWQWGVDAGLGELGVC---FG--HNPW-YDAC----VEPPCGQ----LNPFNDHVYDILKTVYSE------LHG-------LFD-ADVFHMGGDEVHLGCWNMT---KAVTDHMSSDR----SPDAFYHIWGAFQKRARS-LVDA--------------HKKIAIWTSDLTNAPYLRSYF--EPGNTIVQMWTR----SNAGDAAK-LTAQGYEVVASYYDAYYLDCGFGN---WLRKGD-------------------------DWC-HPYHHW----SVLYDLDLVQ---HVPVS-QRRLVLGGEVALWSEEVDEA-TMDAKIWPRAAAAAERWW Solanum_lycopersicum PRFAYRGLLLDTSRHYLPIEIIKQIIESMSYAKLNVLHWHIIDEESFPLEVPSYPNLWK-GAYT-----K-WERYTLEDAIEIVDFAKMRGINVMAEVDVPGHAES-WGAGY---PDL--------------WPSPSC----KEP--------LDVSKNYTFDVISGILAD------MRK-------IFP-FELFHLGGDEVNTTCWTTT---PHVKQWLQDHK----M--TAKDAYQYFVLKAQE-IAIS----H---------NWTPVNWEETFNNFPSKL------NPRTVVHNW------LVGDVCAK-AVASGFRCIYSNQGYWYLD--------HLDV---------------------------PWE-EVYYAE----PLEGIKSIS----------EQKLILGGEVCMWGETADAS-DVQQTIWPRAAAAAERLW Solanum_tuberosum PRFAYRGLLLDTSRHYLPIEIIKQIIESMSYAKLNVLHWHIIDEESFPLEVPSYPNLWK-GAYI-----K-SERYTVEDAIEIVDFAKMRGINVMAEVDVPGHAES-WGAGY---PDL--------------WPSPSC----KEP--------LDVSKNYTFDVIAGILAD------MRK-------IFP-FELFHLGGDEVNTTCWTTT---PHVKQWLQDHN----M--TAKDAYQYFVLKAQE-IAIS----H---------NWTPVNWEETFNNFPSKL------NPRTVVHNW------LRGDVCAK-AVASGFRCIWSNQGYWYLD--------HLDA---------------------------PWE-EVYYAE----PLEGIKSIS----------EQNLVLGGEVCMWGETADAS-NVQQTIWPRAAAAAERLW Spodoptera_frugiperda_Hex2 PKYTHRGLLVDTSRHYITVPTLLKTLDAMEMNKMNVLHWHIVDDQSFPYKSDMFPQLSD-AAYD-----P-TMVYTAVDITQIVSYARHRGIRVLPEFDVPGHTSS-WGVAY---PNILTKC------------YSLG----RELGLGP----MDPTKNITYKLIGDLIRE------VQE-------RFP-DKYFHVGGDEVELDCWISN---SEIRDFMKDHN----M-TDASELHSYFMANVIP-LLGD--------------RSKPIVWQEVFDEGVSL-------PSGTIVQVWKN----TEAREMQN-ILSGGYKVIYSSS--WYLD--------HINGGG-------------------------DWA-KYYGVD----PREIVKGSVP-------EDKEVDILGGEACMWGEVVDDT-NIISRVWPRASAVAEALW Spodoptora_frugiperda_Hex1 PRYTYRGLLIDTSRHYLSVANILKTLDAMEMNKMNVLHWHIVDDQSFPYQSERFPQLSEQGAYD-----P-SMIYTKANINKIIKYAQDRGIRVLPEFDVPGHTRS-WGVAY---PGILTEC------------YKSG----KVVGLGP----MDPTKNITYKLIGELFHE------VQE-------LFP-DKYFHLGGDEVALNCWRSN---PAICKFMDNHN----M-TRTSELHAYFMTKVLP-LLDQ--------------KSKPIVWQEVFFNNVTL-------PSDAIVQVWKT----IGPKDMIS-VLQANHKVIYSAS--WYLD--------YLANGG-------------------------DWE-GFYAVD----PRQLIPKHYK-------ELDLNKILGGEACMWGEAVDDR-NLISRVWPRASAVAEKLW Streptomyces_cyaneogriseus_ PRYAWRGAMLDVARHFFTVDEVKRYIDQIALYKINKLHLHLSDDQGWRIAVDSWPRLAPYGGSTEVGGGP-GGYYTKEQYKEIVRYAGSRHLEVVPEIDMPGHTNAALASYAELNCDGVAPP------------LYTG----IKVGFSS----LCVGKDITYDFIDDVVRE------VAA-------LTP-GRYFHIGGDE---------------------------AHSTSHADYVAFMDRVQP-VVAK----Y---------GKTVIGWHQLTGATP---------AEGALAQYWGLDRTSAAEKAQVAKAAQNGTGLILSPADRSYLDMKYTK---DTPLGL-------------------------SWA-GYVEV-----RRSYDWDPGA---YLPGA-PASAIRGVEAPLWSEAIENSAHIDHMAFPRLPGIAELGW Streptomyces_olivaceoviridis PRYGWRGAMLDVSRHFFTVDEVKRYIDQLALYKINKLHLHLSDDQGWRIAIDSWPNLAAYGGSTEVGGTP-GGFYTKDEYKEIVRYASSRFLEVVPEIDMPGHTNAALASYAELNCDGVAPP------------LYTG----IRVGFSS----LCVGKDITYDFVDDVVRE------IAE-------LTP-GRYFHIGGDE---------------------------GHSTPHADYVAFMDRVQP-VVAK----Y---------GKTVIGWHQLTSANP---------AEGALAQYWGVDATGAAEKARVAAAAQNGTGLILSPADRVYLDMKYDR---NTQLGL-------------------------SWA-GYVEV-----QRSYDWDPGA---YLPGA-PESAIRGVEAPLWTETIENSAHIEHMAFPRLPGVAELGW Streptomyces_toyocaensis PRFGWRGAMLDVSRHFFSVDEVKRYIDQIALYKINKLHLHLSDDQGWRIAVDSWPRLATYGGSTEVGGGP-GGYYTKADYKEIVRYASSRHLEVVPEIDMPGHTNAALASYADLNCDGVAPP------------LYTG----TKVGFSS----LCVGKEITYDFVDDVVRE------TAA-------LTP-GRYLHIGGDE---------------------------AHSTPHEDFVTFMDRVQP-IVAK----Y---------GKTVVGWHQLTGAEP---------AEGALVQYWGLDRTSDAEKERVAEAARNGTGLILSPADRAYLDMKYDK---NTPLGL-------------------------SWA-GYVEV-----RRSYDWDPGT---YLPGV-PASAVRGVEAPLWTETLSESGELEYMAFPRLPGIAELGW Thraustotheca_clavata PFYPHRGVSLDTSRQFYSVASIRRLLDGMGATKLNSFHWHLTDSSSFPIEIKSEPRLTSNGAFS-----S-HKVYTQREIRELVAYGKARGVRIIPELDAPAHAGAGWQWGAKAGLGELGVC---FQ--HNPW-PEAC----VEPPCGQ----LNPFNDHVYDILDMVYGE------LDY-------LFE-SDVFHMGGDEVHLGCWNMS---EAVTKHMTNR-----TSKAFYNVWGMFQEKARA-LVRQ--------------EKIAI-WTSDLTKAPYLNKYF--DPNSTIVQMWTL----STSSDAKF-YTSQGYSVIASYYDAYYLDCGFGN---WILKGS-------------------------DWC-HPYHHW----SVLYDLNLLH---NVPQK-HHKLVLGGEVALWSEEADES-SMDVKIWPRAAAAAERWW Tribolium_castaneum PRFPHRGFLLDTSRHFEPVRIILQMLDAMAYNKLNVFHWHITDDHSFPYKSRTYHELSDKGAYH-----PVSGVYEQSDVMKIIEYARVRGIRVIPEFDTPGHTRS-WGVAH---PELLTSC----------F-TDNV----ANGELGP----MDPTKDTTYDFINNLFTE------IVD-------VFP-DSYFHIGGDEVEFDCWKSN---PDVSNFMKQNN----F-STYEQLESYFIQHVVD-ILDN----L---------SSKYLVWEEVFVNGVEL-------PNSTVVHVWKD----NGLSTLNN-VIKAGKYGLYSSC--WYLS--------VLHSGS-------------------------DWD-AFYKCE----PGLLLHTEE----------EKKLLLGGEACMWGEYVNEF-SVIPRVWPRASAVAERLW Trichoderma_atroviride PNYPHRGVMLDLARTYQTVADIKRTIDAMSWNKLNRLHLHITDSQSWPLVIPSLPKLSQEGAYH-----P-SLVYSPADLAGIFQYGIDRGVEVITEIDMPGHIGV-VELAY---SDLIVAY----Q--EMPY-QYYC----AEPPCGA----FSLNDSKVYDFVDKLFDDL-----LPR-------VTPYSSYFHTGGDELNANDSMID---PRLKSN---------SSDVLQPLLQKFISHAHSKIRAQ--------------GLSPLVWEEMVTTWNLTL------GSDTVVQSW------LGGDAVKN-LAESGYKVIDTDYNFYYLDCGRGQ---WVNFPN--------------GDSFNTYYPFSDWC-APTKNW----RLIYSHDPAK---GVSKA-NAKNVLGGELAIWSEMIDGS-NMDNIIWPRGSAAGEVWW Trichoderma_harzianum_Hex1 PKYPHRGIMLDLARNYQTIDDIKRTIDAMSWNKLNRLHLHITDSQSWPLVIPSLPKLSQAGAYH-----P-SLVYTPADLAGIFQYGVARGVEVITEIDMPGHIGV-IELAY---SDLIVAY----E--EMPY-QYYC----AEPPCGA----FSINNTKVYSFLDTLFDDL-----LPR-------VAPYSAYFHTGGDELNANDSMLD---SHIKSN---------ETSVLQPLLQKFINFAHSKVRAA--------------GLSPFVWEEMVTTWNLTL------GSDTVVQSW------LGGDAVKN-LAESGHKVIDTDYNFYYLDCGRGQ---WVNFPP--------------GDSYNTYYPFNDWC-QPTKNW----RLIYSHDPAA---NVSAS-AAKNVLGGELAIWSEMIDAS-NLDNIIWPRGSAAGEVWW Trichoderma_harzianum_Hex2 PKYPHRGLLLDVSRHWFEVSDIERTIDALAMNKMNVLHLHATDTQSWPLEIPSLPLLAEKGAYH-----K-GLSYSPSDLASIQEYGVHRGVQVIVEIDMPGHVG--IDKAY---PGLSNAY----G--VNPW-QWYC----AQPPCGS----FKLNNTDVEKFIDKLFEDL-----LPR-------LSPYSAYFHTGGDEYKANNSLLD---PALRTN---------DMNTLQPMLQRFLDHVHGKVRDL--------------GLVPMVWEEMILDWNATL------GKDVVAQTW------LGGGAIQK-LAQAGYKVIDSSNDFYYLDCGRGE---WLDFAN--------------GDPFNNNYPFLDWC-DPTKNW----KLMYSHEPTD---GVSDD-LKKNVIGGEVAVWTETIDPT-SLDSIIWPRAGAAAEIWW Trichoplusia_ni PTYPYRGILLDTARNYYSIDSIKATIDGMAAVKLNTFHWHITDSQSFPFEVSKRPQLSKLGALT-----P-AKVYTKEMIKEVVEYGLVRGVRVLPEFDAPAHVGEGWQDTG------LTVC---FN--AEPW-SHYC----VEPPCGQ----LNPTKEELYEYLEDIYQE------MAD-------TFN-TDIFHMGGDEVSERCWNTS---EEIQNFMIQNRWDVGDKSSFLKLWNYFQKKAQDKAYKA----FGK-------KLPLILWTSTLTDYTHVDKFL--DKDDYIIQVWTT----GVDPQIKG-LLEKGYRLIMSNYDALYLDCGYGA---WVGEGN-------------------------NWC-SPYIGW----QKVYDNSPAA----IAKE-YKHLVLGGEAALWSEQSDTA-TLAGRLWPRAAALAERLW ; END;