#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 19, 2025; 11:54 GMT TreeBASE (cc) 1994-2008 Study reference: Lohtander K., Pasonen H., Aalto M., Palva T., Pappinen A., & Rikkinen J. 2008. Phylogeny of chitinases and implications for estimating horizontal gene transfer from chitinase transgenic silver birch (Betula pendula). Environmental Biosafety Research, null. TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S2145] BEGIN TAXA; TITLE TaxonLabelSet13883; DIMENSIONS NTAX=83; TAXLABELS Aeromonas_punctata_78 Alteromonas_sp_4 Alteromonas_sp_67 Anopheles_gambiae_33 Aphanocladium_album_61 Arabidopsis_thaliana_18 Arabidopsis_thaliana_19 Arthrobacter_sp_3 Aspergillus_nidulans_26 Aspergillus_nidulans_54 Autographa_VIRUS_76 Bacillus_cereus_15 Bacillus_circulans_12 Bacillus_halodurans_13 Bacillus_thuringiensis_14 Betula_pendula_20 Betula_pendula_21 Bombyx_VIRUS_77 Bos_taurus_36 Bos_taurus_40 Brugia_malayi_31 Bufo_japonica_35 Burkholderia_cepacea_82 Caenorhabditis_elegans_30 Candida_albicans_50 Cellulomonas_uda_44 Clostridium_paraputrificum_2 Clostridium_thermocellum_1 Coccidioides_posadasii_57 Colwellia_sp_66 Doohwaniella_chitinasigens_42 Drosophila_melanogaster_34 Entamobaea_dispar_24 Entamobaea_histolytica_25 Entamoeba_invadens_23 Enterobacter_sp_83 Glossina_morsitans_32 Grifola_umbellata_52 Halobacterium_sp_9 Helicoverpa_VIRUS_73 Homo_sapiens_37 Homo_sapiens_39 Hypocrea_rufa_59 Hypocrea_virens_55 Janthinobacterium_lividum_41 Kluyveromyces_lactis_28 Kurthia_zopfii_11 Listonella_anguillarum_70 Metarhizium_flavoviride_62 Microbulbifer_degradans_45 Momordica_charantia_16 Mus_musculus_38 Neurospora_crassa_27 Neurospora_crassa_56 Neurospora_crassa_58 Nicotiana_tabacum_17 Nostoc_punctiforme_22 Oceanobacillus_itheyensis_10 Orygia_VIRUS_75 Pantoea_agglomerans_80 Pichia_etchellsii_29 Pseudoalteromonas_sp_65 Rhizopus_microsporus_53 Sagittula_stellata_68 Salmonella_enterica_64 Schewanella_baltica_79 Serratia_marcescens_81 Sodalis_glossinidius_63 Spodoptera_VIRUS_74 Stenotrophomonas_maltophilia_43 Streptomyces_coelicolor_46 Streptomyces_coelicolor_49 Streptomyces_coelicolor_6 Streptomyces_lividans_48 Streptomyces_olivaceoviridis_7 Streptomyces_thermoviolaceus_47 Thermococcus_kodakaraensis_8 Trichoderma_harzianum_60 Ustilago_mayidis_51 Vibrio_cholerae_69 Vibrio_parahaemolyticus_5 Vibrio_parahaemolyticus_71 Vibrio_vulnificus_72 ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M3807] TITLE 'Class V chitinases, Fig. 4'; LINK TAXA = TaxonLabelSet13883; DIMENSIONS NCHAR=605; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 ] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] Aeromonas_punctata_78 FTVDKIP----AQNLTHILYGFTPICGGNG-INDSLKEIS----------------GSFEALQRSCAGRED--FK-------VSIHDPWA--AIQMSQGNL---SAWD---EPYKG-N-FGNLMALK----QAHP-DLKILPSVGGW------------TL---SDPFYF-------------------LGDK-TKRDTFVASVKEF-------LQTWK--------FFDGVDID--WEFPGG--QGANPSL-----GGPN-DGATYVVLMKELRA-MLDELEAET--GRQ----YELTSAISA-GGD----KIAK------VDYQAAQQYMDH-IFLMSYDFSGA-FDLT---NLAHQTNLFGSSW-----------------DPATKYT---------TDKG--VKALLGQG-VTPGKIVVGAAMYG-RGWTGVKNYQAG-----------NP------FTGTA----------TG--PVSGT------------------------W-E-NG-------VVDYRDIVNNRMG--------AGWEQGYDE----SAEAPYVFKASSGDLITFD--NDRSVKTKGQYVLANQLGGLFAWEIDAD Alteromonas_sp_4 YLVDDIP----WDKITHINYAFAHVDANN---KVSIGN----------------------------PTAPN--NA--------ATNMTWP--GVA--------GAEMDPS-LPYT--GHFNLLNKFK----KQHP-DVKTLISVGGW------------AE---TGGYFDETGKRIASGGFYTMTTNADGSVNHAGIDAFVASSVEF-------IRKYN---------FDGVDID--YEYPSSMNDSGHPDDFAISNPRRAALNASYQVLMKKLRE-ALDQAGQQD--NTH----YLLTIASPSSGYL-----LRG------METFQVTKYLDY-VNIMSYDLHGA-WNQ----HVGHNASLFDTGEDS-------------ELKQWNVYGTKEFEGIGYLNTDWAVK-YFRGS-VSAGRINIGIPYYT-RGFRDVTGGTNGLWGQAALPNQADC------PPGTGS--GEKNKCGNGAVGIDNLWHDKNDVGLEVPAGSNPLWHVKNLQ-N-GV-------LGSYLSDYGLDPVNNPEHQISGTYARHYDS----VAVAPWLWNATKNVFLSIE--DEESMAAKVDYVINQELGGIMFWELAGD Alteromonas_sp_67 YDVTKIP----AHNLSHILYGFIPICGP----NESLKSIEI--------------GNSWRALQTACADSQD--YE-------VVIHDPWA--AVQKSMPGV----DAK---DPIRG-V-YSQLMALK----QRYP-DLKILPSVGGW------------TL---SDPFHG-------------------FTNK-ANRDTFVASVKQF-------LKTWK--------FYDGVDID--WEFPGG--DGPNPDL-----GDPINDGPAYVALMQELRA-MLDELEAET--GRQ----YELTSAIGA-GYD----KIED------VDYQAAQQYMDY-IFAMTYDFYGA-WNN----ETGHQTGIYCGSHLSTDECNGTGVDDNGVPRKGPAYT---------GDHA--IQLLLQQG-VQPSKLVMGVAMYG-RGWEGVLDANAA-IP-------GNP------MTAPG----------NG--PLTGSTSE-------------------GVW-E-PG-------IMDYKAIAANAVGQGG--SGVNGYEVGYDE----QAQAAYVWNRSNGKLITYD--SPRSVIAKGQYANTHQLAGLFGWEIDAD Anopheles_gambiae_33 YDIEHID----PSLCTHLMYGFFGINEDA---TVRIIDP-------------------------------------------------YL--DLEENWG-----------------RGHIKRFVGLK----NVGP-GLKTLAAIGGW------------NE---GSRK------------------FSAMAASGELRKRFISDCVAF-------CQRHG---------FDGIDLD--WEYPA--QRDGNPL----------IDRDNHAQLVEEMREEFDHYG-------------LLLTAAVASVEFS----AGVS------YDIPRISKSFHF-LNVMVYDMHGA-WDS----YCGINAPLYRGSADTTDRL------------G---QI----------NVNASIHFWLAQG-CTGRKLVLGIPLYG-RNFTLASAANTQ------I---GAP------TVGGG---------------TVGRYT----------------------R-E-PG-------VMGYNEFCEKLATE--------AWDLRWSE----EQQVPYAVR--NNQWVGYD--DLRSVQLKVKYLLDQGLGGAMVWSLETD Aphanocladium_album_61 FQPADLP----ASEITHVLYSFMNVRA-D---GTIFSG------------------DTYADYEKHYAG------------------DSWN--DVGTNAY------------------GCVKQLYLLKK----QNR-NMKVMLSIGGW------------TW---STNFPA-------------------AASSAATRKTFAQSAVGF-------MKDW---------GFDGIDID--WEYPADA-----------------TQAQNMVLLLQAVRS-ELDSYAAQYAKGHH----FLLSIAAPA-GPD----NYNK------LKFAELGKVLDY-INLMAYDYAGS-WSN----YTGHDANIYANPQNP----------------NATPYN---------TDDA--VQAYINGG-VPANKIVLGMPIYG-RSFQQTEGIG-K------------P------YNGIG----------------SGS------------------------W-E-NG-------IWDYKALPKAGAT------------VKCDD----TAKGCYSYDPSTKELISFD--TPAMISTKVSWLKGKGLGGTMFWEASAS Arabidopsis_thaliana_18 PAT-DID--SSLF--THLFCTFADLEAESY--EITIAT------------------------------------------------WNQA--PFH-A----------------------FTETVQQR------NP-HVKTLLSIGGG------------NA---DKDAFA------------------SMASNPDSRASFIQSTITV-------ARSYG---------FHGLDLD--WEYPR-----------------NEEEMYDFGKLLEEWRSAVEA----ESNSSGTTA--LILTAAVY-YSSNYQ--G-VP------YPVLAISNSLDW-INLMAYDFYGPGWST----VTGPPASLYLPTD------------------GRSGDS------------G--VRDWTEAG-LPAKKAVLGFPYYG-WAWTLADPDVN---------GYDAN------TTGPAIS-------------DDGEIS----------------------Y-R-Q---------LQTWIVDNGATK-------------VHDD----MMVGDYCYAGT--TWIGYDS-EKSIVTKV-IYAKQKGLLGYFSWHVGGD Arabidopsis_thaliana_19 PLA-QID--SSLF--THLFCAFADINTLTY--QVIVSS------------------------------------------------RNKP--KFS-T----------------------FTQTVRRR------NP-TVKTLLSIGGD------------FT---YNFAFA------------------SMASNPTSRKLFISSSIKL-------ARSCG---------FHGLDLN--WKYPS-----------------ITTEMDNFGKLLREWRLAVEA----EARSSGKPR--LLLTAAVF-YSYSYY--S-VL------HPVNAVADSLDW-VNLVAYDFYESGSSR----VTCSPAPLYDPIT-T----------------GPSGDA------------G--VRAWTQAG-LPAKKAVLGFPLYG-YAWCLTDAKNH---------NYYAN------SSGPAIS-------------PDGSIG----------------------Y-D-Q---------IRRFIVDNKATM-------------VYNS----NLVQNYCYAKK--TWIGYDD-NQSIVMKV-KYAKQRGLLGYFSWHIGAD Arthrobacter_sp_3 YLASDIP----WKKLSHINYAFAHIDKNN---KVSVG-----------------------------AETPG--NA--------ATDLTWP--GGC--------GAEMDPT-LPYK--GHLNQLKKFK----KENP-GVKTLVSVGGW------------AE---TGGHFAADGTRVGDGGFYTLT-ES-----QAKIDTFSDSAVEF-------IRKYG---------FSGVDID--YEYATSNSKAGNPDDFAISEPRRAVLFENYMKLMKTLRE-KLDKASVAD--GTY----YQLTVAAPASGWL-----LRG------MEAHQVVKYLDF-VNMMSYDLHGA-WNN----FVGGNPALFDDGKDP-------------ELAAGGVYN--AYKGIGYLNSDWAYH-YFRGA-MPAGRINLGVPFYT-RGWTNVQGGTNGLYGSSVLADQNKC------APGTGPKAGGNSKCGDGAGGIDNLWHDSDPMGGELAAGANPIWHVLNLQ-K-GV-------VGDYAASYGS-PTGA----LKGTYTRHFDN----VTKNEWWWNDTTKTFLSGD--ADQAIQAKADYVADKGLGGVMIWELAGD Aspergillus_nidulans_26 LNPEDLL----MGAYTHLNYAFAFIDPES---YKIANM------------------------------------------------QDSD--EEY------------------------MPRLTALK----NYNP-SLEVWIAIGGW------------SMNDPDQPTRR---------------TFSELAASKSHQDVFFESLLSF-------MDKYG---------FDGVDID--WEYPVAEERSGAPED-----------FENYVSFLKNL---RAVLG--------N----RGLTITLPASFWY-----LQH------FDIKNMEPILDW-FNIMSYDLHGT-WDGTNP-YLGPYINSHTNLT------------------EIDLA----------------MELLWRND-IDPKKVVMGMGFYG-RSFTLSDPACN------------TP------GCGFS---------------AGGN-------------------PGKCSA-S-AG-------SLMFSEIQEIIDAG--------G-AKVTND----EKAGVQMVTWDTNQWVSYD--DDETLKAKMEYANELCLGGVMVWAASTD Aspergillus_nidulans_54 YNPQDLP----AEKLTHILYAFANVRPET---GEVYLS------------------DTWSDIEKHYPT------------------DSWN--DTGNNVY------------------GCVKQLGLLKR----QHR-QLKVLLSIGGW------------TY---SPNFTN-------------------GAGTPENRARFAQTATKL-------ITDL---------GFDGIDID--WEYPQND-----------------QQAQNYVDLLRRCRE-ALNAAQGQR----R----FQLTVAVPA-GPD----NYNK------LRLQEMTPYLDF-YNLMAYDYAGS-WDQ----TAGHQANLYPSTSNP----------------TSTPFN---------TVQA--VNHYIDAGGVPSNKIILGMPIYG-RAFQNTDGPG-R------------P------YSGIG----------------QGT------------------------W-E-QG-------VYDYKALPRPGAT------------EQLDT----NIGASWSYDPSSREMVSYD--TVAAADLKAAYIQSRRLGGAMWWETSAD Autographa_VIRUS_76 FPVDKVP----LPNLSHLLYGFIPICGGDG-INDALKTIP----------------GSFESLQRSCKGRED--FK-------VAIHDPWA--AVQKPQKGV---SAWN---EPYKG-N-FGQLMAAK----LANP-HLKILPSIGGW------------TL---SDPFYF-------------------MHDV-EKRNVFVDSVKEF-------LQVWK--------FFDGVDID--WEFPGG--KGANPSL-----GDADGDAKTYILLLEELRA-MLDDLEAQT--GRV----YELTSAISA-GYD----KIAV------VNYAEAQKSLGK-IFLMSYDFKGA-WSNT---DLGYQTTVYAPSW-----------------NSEELYT---------THYA--VDALLKQG-VDPNKIIVGVAMYG-RGWTGVTNYTND-----------NY------FSGTG----------NG--PGSGT------------------------W-E-DG-------VVDYRQIQKDLN----------NYVYTFDS----AAQASYVFDKSKGDLISFD--SVDSVLGKVKYVDRNKLGGLFAWEIDAD Bacillus_cereus_15 YQVADID----ASKLTHLNYAFADICWNG---KHGNPSTH---------------PDNPNKQTWNCKESGVPLQNKEVPNGTLVLGEPWA--DVTKSYPGS--GTTWEDC-DKYARCGNFGELKRLK----AKYP-HLKTIISVGGW------------TW---SN-RFS------------------DMAADEKTRKVFAESTVAF-------LRAYG---------FDGVDLD--WEYPGV---ETIP-----GGSYRPEDKQNFTLLLQDVRN-ALNKAGAED--GKQ----YLLTIASGASQRY-----ADH------TELKKISQILDW-INIMTYDFHGG-WEA----TSNHNAALYKDPND------------------PAANTN--------FHVDGAINVYTNEG-VPVDKLVLGVPFYG-RGWKSCGKENNGQY--------QPC------KPGSD-----------GKLASKGTWDDYSTGD----TGV-------------YD-------YGDLAANYVN----------KNGFVRYWND----TAKVPYLYNATTGTFISYD--DNESMKYKTDYIKTKGLNGAMFWELSGD Bacillus_circulans_12 YNVTDID----PTKVTHINYAFADICWNG---IHGNP--D---------------PSGPNPVTWSCQNEKSQTIN--VPNGTIVLGDPWI--DTGKQFA----GDTWD---QPYA--GNINQLNKLK----QVNP-NLKTIISIGGW------------TW---SN-RFS------------------DVAATSATREVFANSAVDF-------LRKYN---------FDGVDLN--WEYPVS---GGLD-----GNSKRPEDKQNYTLLLSKIRE-KLDAAEAVD--GKE----YLLTIASGASPTY-----AAN------TELANIASIVDW-INIMTYDFNGA-WQK----ISAHNAPLNADPAAA-------------SAGVPDSNT---------FNVAAGAQGHLNAG-VPAAKLVLGVPFYG-RGWDGCAQANNGQY--------QTC------SGG----------------SSIGTWEA----------GS-------------FD-------FYDLEANYIN----------KNGYTRYWND----TAKVPFLYNASNKRFISYD--DAESIGHKTAYIKSKGLGGAMFWELSGD Bacillus_halodurans_13 YQVWDID----ASKISHINYAFANICWDG---RHGNP--D---------------PAGPNPQTWSCQDENG-VID--VPNGSIVMGDPWI--DAQKSNP----GDTWD---EPLR--GNFKQLNKLK----EEHP-HLKTLISVGGW------------TW---SN-RFS------------------DMAATKETRENFANSAVEF-------IRKYG---------FDGVDVD--WEYPVS---GGLP-----GNSRRPEDKENHVLLLQEVRD-KLDEAGQED--GKD----YLLTIASGASPGY-----VEN------NKLNEIAEIVDW-INIMTYDFNGG-WQN----ISGHNAPLYYDPATA-------------NTELPTPEH---------FNVESAVEGHLQAG-VPEHKLVLGMPFYG-RGWSNCDGANQGEY--------QRC------AP-----------------PREGTWEN----------GV-------------FD-------FSDLEDHYIN----------KNGYQRYWND----VAKVPFLYNATNGNFITYD--DEESFRYKTDFIKSNNLAGSMFWDVSGD Bacillus_thuringiensis_14 YQVADID----ASKLTHLNYAFADICWNG---KHGNPSTH---------------PDNPNKQTWNCKESGVPLQNKEVPNGTLVLGEPWA--DVTKSYPVS--GTTWEDC-DKYARCGNFGELKRLK----AKYP-HLKTIISVGGW------------TW---SN-RFS------------------DMAADEKTRKVFAESTVAF-------LRAYG---------FDGVDLD--WEYPGV---ETIP-----GGSYRPEDKQNFTLLLQDVRN-ALNKAGAED--GKQ----YLLTIASGASQRY-----ADH------TELKKISQILDW-INIMTYDFHGG-WEA----TSNHNAALYKDPND------------------PAANTN--------FYVDGAINVYTNEG-VPVDKLVLGVPFYG-RGWKSCGKENNGQY--------QPC------KPGSD-----------GKLASKGTWDDYSTGD----TGV-------------YD-------YGDLAANYVN----------KNGFVRYWND----TAKVPYLYNATTGTFISYD--DNESMKYKTDYIKTKGLSGAMFWELSGD Betula_pendula_20 RVQ-NSD--RYSFPLTHFYLG-IDLGSSDYN-QEISST------------------------------------------------KRSP--QFETS----------------------FADTVRQR------WP-DVKILLSIGG------------------DPSFLA------------------EIASNEESRRAFIDYVPSL-------LRLWK---------FDGFDLR--WLYPV-----------------TALEMANFGSLLTGLREALP------------PP--LLLTAAVF-YSPYYW--SSLE------YPIQAIVDSCDW-INVLAFDLYTPDSSPK---LT????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????? Betula_pendula_21 RVQ-NSD--RYSFPLTHFYLG-IDLSSSDYN-QEISST------------------------------------------------TRSP--QFETS----------------------FADTVRQR------WP-DVKILLSIGGE------------SG---DPSFLA------------------EIASNEESRRAFIDYVPSL-------LRLWK---------FDGFDLR--WLYPV-----------------TALEMANFGSLLTGLREALP------------PP--LLLTAAVF-YSPYYW--SSLE------YPIQAIVDSCDW-INVLAFDLYTP??????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????? Bombyx_VIRUS_77 FPVDKVP----LPNLSHLLYGFIPICGGDG-INDALKTIP----------------GSFEALQRSCRGRED--FK-------VAIHDPWA--AVQKPQKGV---SAWN---EPYKG-N-FGQLMAAK----LANP-HLKILPSIGGW------------TL---SDPFYF-------------------MHDV-EKRNVFVESVKEF-------LQVWK--------FFDGVDVD--WEFPGG--KGANPSL-----GDAERDAKTYILLLDELRE-MLDDLEVQT--GRV----YELTSAISA-GYD----KIAV------VNYAEAQKSLDK-IFLMTYDFKGA-WSNT---DLGYQTTVYAPSW-----------------NSEELYT---------THYA--VDALLEQG-VDPNKIIVGVAMYG-RGWTGVTNYTNG-----------NY------FSGTG----------NG--PVSGT------------------------W-E-DG-------VVDYRQIQKDLN----------NYVYTFDS----AAQASYVFDKSKGDLISFD--SVDSVLGKVKYVDRNKLGGLFAWEIDAD Bos_taurus_36 ILPRDLD----PFLCTHLVFAFASMSNN----QIVPKD--------------------------------------------------PQ--DE----------------------KILYPEFNKLK----ERNR-GLKTLLSIGGW------------NF---GTVR------------------FTTMLSTFSNRERFVSSVIAL-------LRTHG---------FDGLDLF--FLYPG--LRGSPA-----------RDRWTFVFLLEELLQAFKNEAQLTM--RPR----LLLSAAVSGDPHV----VQKA------YEARLLGRLLDF-ISVLSYDLHGS-WEK----VTGHNSPLFSLPGDP----------------KSSAY---------------AMNYWRQLG-VPPEKLLMGLPTYG-RTFHLLKASQNE------L---RAQ------AVGPA---------------SPGKYT----------------------K-Q-AG-------FLAYYEICCFVR----------RAKKRWIN----DQYVPYAFK--GKEWVGYD--DAISFGYKAFFIKREHFGGAMVWTLDLD Bos_taurus_40 FKPDNID----PCLCTHLIYAFAGMSNS----EITTIE--------------------------------------------------WN--D-----------------------VALYSSFNDLK----KKNS-QLKILLAIGGW------------NF---GTAP------------------FTAMVATPENRKTFISSVIKF-------LHQYG---------FDGLDFD--WEYPG--FRGSPS-----------QDKHLFTVLVQETREAFEQEAKQTN--KPR----LLVTAAVAAGISN----IQAG------YEIPQLSQYLDF-IHVMTYDFHGS-WEG----YTGENSPLYKYPTDT----------------GSNTYL----------NVEYAMNYWKKNG-APAEKLIIGFPAYG-HNFILRDASNNG------I---GAP------TSGAG---------------PAGPYT----------------------R-E-AG-------FWAYYEICAFLKD---------GATEAWDD----SQNVPYAYK--GTEWVGYD--NVNSFRIKAQWLKENNFGGAMVWAIDLD Brugia_malayi_31 FLPGNIP----NGLCTHILYAFAKVDELG---DSKPFE---------------------------WNDED----------------TEWS---------------K-----------GMYSAVTKLR----ETNP-GLKVLLSYGGY------------NFG--SAIFTG-------------------IAKSAQKTERFIKSAIAF-------LRKNN---------FDGFDLD--WEYPVG-------------------VAEEHAKLVEAMKTAFVEEAKTSG--KQR----LLLTAAVSA-GKG----TIDGS-----YNVESLGKNFDL-LFLMSYDLHGS-WEK----NVDLHGKLHPTKGEVS---------------GIGIFN---------TEFA--ADYWASKG-MPKEKIIIGIPMYA-QGWTLDNPSETA------------I------GAAAS----------R---PSSASKT----------------------N-PAGG-------TASYWEICKYLKE---------GGKETVHQ----EGVGAYMVK--GDQWYGYD--NEETIRIKMKWLKEKGYGGAFIWALDFD Bufo_japonica_35 YVPGNID----PQLCTHLVYAFATMNEH----KIAPYE--------------------------------------------------WN--D-----------------------DVLYKQFNDLK----QKNK-NLVTLLAIGGW------------NF---GTQK------------------FTDMVASSGNRSIFIKSVIAY-------LRQNN---------FDGIDLD--FEYPG--SRGSPP-----------EDKQRFTVLIQEMLDAFNEEARSSG--LPR----LLITAAVSAGKGT----IDAG------YEIAKIGQLLDF-ISVMTYDFHGG-WDT----QSGHNSPLCKGSTDY----------------GDLQYF----------NIHFAMNYWKNNG-APAEKLLLGFPTYG-RTFRNPNPNMCD------V---GIP------VSGAG---------------SAGPYT----------------------R-E-AG-------FWAYYEICTWLS----------GSTVKWIP----DQRVPYACK--SNEWVGFD--NQESYECKVRFLKESGFGGAMVWAIDLD Burkholderia_cepacea_82 FTVDKIP----AQNLTHLLYGFIPICGGNG-INDSLKEIE----------------GSFQALQRSCQGRED--FK-------VSIHDPFA--ALQKAQKGV---TAWD---DPYKG-N-FGQLMALK----QAHP-DLKILPSIGGW------------TL---SDPFFF-------------------MGDK-VKRDRFVGSVKEF-------LQTWK--------FFDGVDID--WEFPGG--KGANPNL-----GSPQ-DGETYVLLMKELRA-MLDQLSAET--GRK----YELTSAISA-GKD----KIDK------VAYNVAQNSMDH-IFLMSYDFYGA-FDLK---NLGHQTALNAPAW-----------------KPDTAYT---------TVNG--VNALLAQG-VKPGKIVVGTAMYG-RGWTGVNGYQNN-----------IP------FTGTA----------TG--PVKGT------------------------W-E-NG-------IVDYRQIAGQFMS--------GEWQYTYDA----TAEAPYVFKPSTGDLITFD--DARSVQAKGKYVLDKQLGGLFSWEIDAD Caenorhabditis_elegans_30 FVPEDYT----PGLCTHILFAFGWMNADY---TVRAYDP---------------------------ADLP----------------NDWA--G------------E-----------GMYRRVNKLK----VTDT-QLKTLLSFGGW------------SFG--TALFQG-------------------MAASSASRKVFIDSAITF-------VRTWG---------FDGIDID--WEYPSG-----------------ATDMANYVALVKELKAACESEAGSTG--KDR----LLVTAAVAA-GPA----TIDAG-----YDIPNLAPNFDF-ILLMSYDFFGA-WAS----LVGFNSPLYATTELP---------------AEWNGWN---------VDSS--ARYWNQKG-MPKEKIIVGMPTYG-RGWTLNNASAIN------------P------GTSGS--------------PAKITQY---------------------VQ-E-AG-------VGAYFEFCEMLAN---------GATRYWDS----QSQVPYLVQ--GNQWWSYD--DEESFANKMAYVKREGYGGAFVWTLDFD Candida_albicans_50 HFPQDIP----IEYFTHIFYAFILIDEQTG--KLKFS-------------------------------------------------DEWC--DLQMPQPSP-----------NQSITGNLQQFYEMK----KKNR-HLKLIMSIGGW------------GI---CHLFES-------------------VVSNDTKFDNFVNSTIEF-------VEKYG---------FDGVDID--WEYPKN-----------------STQAAKLVELLARLRN-KLNS---K----------YIITVAAPG-GSD----NIEI------LKIQEMDKYLTF-WNLMCYDFAGEGWSS----KTAFHSNLFGNNG-------------------DNSLN-----------ASDVVQTYINKG-VHPTKLILGMPMYG-RIFHGVDRPEIG-----------IP------FTKER---------------KSGC--------------------------IEAD-------VVDYNKFGDTFDY------------EDFDP----RKVGALKYDSHSKQLITFD--NPQCARIKASFVQSRQLGGGMWWDSAGD Cellulomonas_uda_44 YHVNNIRTSGSASKLTHILYAFGNT--TGG--RCSI-------------------GDAYAAYDKAYTADQS--VD-------G-VADTWD--Q-------------------PLRG-N-FNQLRKLK----AANP-GLKVLWSFGGW------------TW---SGGFTQ-------------------AAAN---PTAFADSCYSL-------LNDPR-----WAGLFDGIDVD--WEYPNA--CG--LS------CDS-SGPQAFDRVVTALRDKFGS----------S----FLVTAAITADGSSGG--KIDA------TDYATAATKLSW-IMPMTYDYFGA-FNPQG--PTAPHSPLTSYPGIP-----------------QAGFN---------SEDA--VNKLIAKG-IPASKILLGVGFYG-RGWTGVTQSAPG----------------------GSA---------TG--AAPGT------------------------Y-E-AG-------IEDYKVLKNRCP--------------ATGT----VGGTAYAKC--GNEWWSYD--TPATIATKTAWARSKGLGGAFFWELSGD Clostridium_paraputrificum_2 FNATDLQ----WDSLTHIQYSFAMVDPSTN--KITLGD-------------------KHAAIEEDFTG----------------YDLSYKGKIVELDTS------------LPYK--GHFNVLQTMK----KSYP-DVDLLISVGGW------------AG---SRGFYT-------------------MLDTDAGINTFADSCVEF-------IRQYG---------FDGVDID--FEYPSATSQSGNPDDFDLSEPRRSKLNERYNILIKTLRQ-KIDEAAKAD--GKD----YLLTAAVTASPWV-----LGG------VSDNSYAKYLDF-LSVMSYDYHGG-WNE----YVEHLAGIYPNAEDR--------------ETVAQIMP--------TLCMD--WAYRYYRGVLPSEKILMGIPYYT-RGWENVQGGTNGLHG-----TSKTP------ASGKYN--------IWG-DDLDGDGN----------------------L-EPAG----ANPLWHVLNLMENDPN----------LKVYWDD----TSKVPYVWQNNEKVFLSFE--NEKSIDARLDYIKDKNLGGA???????? Clostridium_thermocellum_1 YEVSDIP----WDMVTHINYAFAKI------------------------------------------------EN-----GRIAIIDKWA--AIQKPFG----DDTWD---TPIR--GHFGQLIKYK----EQYP-HVKTLISVGGW------------TE---SK-YFS------------------DVALTEESRNTFADSCVEF-------IRTYR---------FDGVDID--WEYPVS---GGMP-----ENIRRPEDKQNFTLLLKCLRE-KLDAAGAED--GKH----YLLTIAAPAGSFN-----IKN------TEPEIYHQYLDF-INIMTYDYSGS-WEN----VANHLAPLYMNPNDP-------------S--YPERKEK--------FNVDWTVKEYLRLG-VPAEKINVGVPYYA-AGWQEVNGGINGLF--------GTS------SK-----------------PLSSTQFH-------------------------YI-------NSLLKSPDL-------------GFTRYWDE----YAMVPYLWNPESATFYSYE--DEISLKNKCDYVIENNLGGIMIWELSGD Coccidioides_posadasii_57 HNPQDLK----ADQFTHILYAFANIRP-S---GEVYLS------------------DTWADTDKHYPG------------------DKWD--EPGNNVY------------------GCIKQMYLLKK----NNR-NLKTLLSIGGW------------TY---SPNFKT-------------------PASTEEGRKKFADTSLKL-------MKDL---------GFDGIDID--WEYPEDE-----------------KQANDFVLLLKACRE-ALDAYSANHPNGKK----FLLTIASPA-GPQ----NYNK------LKLAEMDKYLDF-WNLMAYDFSGS-WDK----VSGHMSNVFPSTTKP----------------ESTPFS---------SDKA--VKDYIKAG-VPANKIVLGMPLYG-RAFASTDGIG-T------------S------FNGVG----------------GGS------------------------W-E-NG-------VWDYKDMPQQGAQV----------TELED------IAASYSYDKNKRYLISYD--TVKIAGKKAEYITKNGMGGGMWWESSSD Colwellia_sp_66 ????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????GGW------------DL---SDPFYG-------------------FTEK-ANRDTFVASMKQF-------LKTWK--------FYDGVDID--WEFPGG--DGANPNL-----GNPATDGAAYVALMQELRA-MLNELEQES--GRT----YELTSAIGS-GYD----KIED------VDYAAASQYMDY-IFAMTYDFYGG-WNN----VTGHQTGVYCGSHLSTGECDGTGLDDNGEPRKGPAYT---------MDHA--AQLLLAQN-VSPSKIVLGAAMYG-RGWEGVLPANAT-DM-------DNP------MTAPG----------NG--KLTGSNAE-------------------GVW-E-AG-------VIDYKGVKANMIGASG--TGVNGFEVGYDE----QAQAAYVWNRTSGKLITYD--NPRSVKVKGQYVRQHNFAGLFGWEIDAD Doohwaniella_chitinasigens_42 TRVKQIETSGAASKLTFLNYAFGNIYQKNGGYECDIQYRTESG----N----GDGGDPFADYSKSFSADAS--VD-------G-VADKWD--S-------------------PLR--N-FGQIKRLK----ARHP-AISPMISLGGW------------SW---SKWFSA-------------------ASMTDPLRKQLVKSCVDLYIKQSAGMTAQV--VRPAAGVFDGIDID--WEFPGV--QGFGYN------TVSPADKQNFTLLLKEFRSQLDRCVTATT--GKR----YKLTVAIGA-GKD----KIDM------TEPAEYSKYLDW-INVMSYDFHGG-WDAKG--PTDFHSHLSNDPSSPNA-----------ATTLGASYN---------IEGA--VNNLLASG-TPAGKIVVGIPFYG-RGWTGVTNANNG--------------------LYQAA---------TA--PARGT------------------------Y-E-PG-------IEDYKVLKNAAGQ------------VYTHP----VTKQSWKFD--GNNFWSYD--TPANIQTKIDYVKAKTLGGMFSWSLDGD Drosophila_melanogaster_34 FGMEDID----PFLCTHLIYAFLGIEETG---QLRVIDA-------------------------------------------------YL--DLEENSG-----------------RGNIKSFNALK----LKNP-VLKTLVAVGGW------------NE---GSKR------------------FSLVARDPSKREKFVDDVVRF-------LQRHG---------FDGLDLD--WEYPG--QRHSLDN----------EDRSNYITFLKELKEGLEPFG-------------FILSAAVGSAQFS----AEIS------YDIPAMVPYLDL-INVMAYDLHGP-WDQ----VVGINAPLYAAEKDASDSS------------GRQQQL----------NVDAVVKYWLKAG-APAEKLILGVPFYG-RSFTLATAEGNQ------P---GAP------HIGKG---------------IAGNYS----------------------R-E-PG-------VLGYNELCEMMERE--------EWTQKWEA----TQQVPYAYR--QRQWVGYE--DPRSLALKAQYVMDNHLGGIMIWSLESD Entamobaea_dispar_24 YTTDNID----PTIVDVINYAFVVFDSTY---TVKEYE--------------------------------------------------WN--D-----------------------DQMIPKIVAMK----SRNP-NLKVLASIGGW------------NFNFYDSTKHL----------------YSQMAEKQATRATFIKSAMNF-------ARKYN---------LDGIDID--WEYPANEDQGGRP-----------VDTQSFTLLLKEFREAIDKEVGNG---KSK----LLLTIAAPAGPWN----IKN-------IEISKFYKYLDW-INLMTYDLHGS-WDS----VTGPHTALYATDG------------------IS--V-------------DDAVTAYLNAG-VPSAKIMLGMAHYG-RGWTLKSSSDHE------M---GSN------ATGAS---------------KSGTCT----------------------G-E-NG-------YLSKYEIDALIP----------QENIKFDS----KSKTMYGYK--NDQWFSFD--TQETFKYKADYLCKKKLGGVMFWSLDLD Entamobaea_histolytica_25 YTADNID----PTIVDVINYAFVVFDSTY---TLKEYE--------------------------------------------------WN--D-----------------------DQMIPKIVAMK----SRNP-NLKVLASIGGW------------NFNFYDSTKHL----------------YSQMAEKQATRATFIKSAMSF-------ARKYN---------LDGIDID--WEYPANEDQGGRP-----------VDTQSFTLLLKEFREAIDKEAGNG---KSK----LLLTIAAPAGPWN----IKN-------IEVSKFHQYIDW-INLMTYDLHGS-WDA----VTGSHTALYVTDG------------------IS--V-------------DDAVTAYLNAG-VPSTKIMLGMAHYG-RGWTLKSSSDHE------M---GSA------ATGAS---------------KSGTCT----------------------G-E-NG-------YLSKYEIDALIP----------QENIKFDS----KSKTMYGYK--NDQWFSFD--TKETFKYKADYLCKKKLGGVMFWSLDLD Entamoeba_invadens_23 YTPDNID----PTLVDVINYAFVVFDSSY---TVKEYE--------------------------------------------------WN--D-----------------------DQMIPKIVAMK----SKNP-NLQVLASIGGW------------NFNFYDSTKHL----------------FSEMAEKQTSRAAFIKSAMSF-------ARKYN---------LDGIDID--WEYPANKDQGGRP-----------VDVQSFTLLLKEFREAIDAEKLSGG--RSR----LLLTIAAPAGPKN----IEN-------LEISKFHKYLDW-INLMTYDLHGS-WDD----VTGSHTALYADDA------------------LS--V-------------DDAVKAYLSQG-VPPAKMFVGMAHYG-RGWTLKSANKHD------M---GSP------ASGAS---------------TSGKCT----------------------G-E-NG-------YLSKYEIDSLIP----------AANIQYDA----KSMTMFGYS--GDQWFSFD--DKDTFEHKVQYVCDHKLGGAMIWSLDLD Enterobacter_sp_83 FTVDKIP----AQNLTHLLYGFIPICGGNG-INDSLKEIE----------------GSFQALQRSCQGRED--FK-------VSIHDPFA--ALQKAQKGV---TAWD---DPYKG-N-FGQLMALK----QARP-DLKILPSIGGW------------TL---SDPFFF-------------------MGDK-VKRDRFVGSVKEF-------LQTWK--------FFDGVDID--WEFPGG--KGANPNL-----GSPQ-DGETYVLLMKELRA-MLDQLSAET--GRK----YELTSAISA-GKD----KIDK------VAYNVAQNSMDH-IFLMSYDFYGA-FDLK---NLGHQTALNAPAW-----------------KPDTAYT---------TVNG--VNALLAQG-VKPGKIVVGTAMYG-RGWTGVNGYQNN-----------IP------FTGTA----------TG--PVKGT------------------------W-E-NG-------IVDYRQIASQFMS--------GEWQYTYDA----TAEAPYVFKPSTGDLITFD--DARSVQAKGKYVLDKQLGGLFSWEIDAD Glossina_morsitans_32 FEPSNIN----PFLCTHLSYTFFGLSVQG---ELRVLDP-------------------------------------------------WL--DLDS--G-----------------LGNIKRTIALK----EFNP-KLKVIAAIGGW------------NE---GSIN------------------YSNMAADPNKREIFIKSVLQF-------LKAHQ---------FDGLDLD--WEYPA--QRGGAS-----------ADRVNFITLLKELQKSFAPYG-------------YELITAVAASEYS----AKIS------FNIPEMSKYVDY-INVMTYDFVTG-YDA----VLGFNAPLK-GQ-------------------G---AN----------NVEASIKYWLNQG-APASKLVLGLAMYG-HSFQLANPAQAT------A---GSP------SIGPG---------------KSGPYT----------------------I-Q-PG-------MLGYNEICETTTN----------WHYGWDD----RHGVPYKYK--NDQWIGYD--DERSIALKIDLLKSLNLAGAMLWSIEMD Grifola_umbellata_52 FPPSLIP----ADNLTHILYAFANVKSDT---GEVHLS------------------DPWADTDIHYPG------------------DSWN--DQGRNLY------------------GNSKAIYRLKQ----QHR-HLKVILSIGGW------------TY---SPNFHP-------------------VVVNPALRSKFVASSIWL-------LEDH---------GLDGLDVD--YEYPQND-----------------EQARGYVTLLRELRA-GLDAHASRKGANYN----FLLTIAAPC-GPD----NYQK------LHVREMDASLDF-WNMMAYDFAGS-WDK----VSGHQANVF----------------------GGPNKC---------FSSP--LIGTLAQG-VPRDKIVTGIPLYG-RSFMNTEGPG-T------------P------FKGLG----------------PGS------------------------W-E-QG-------VYD-RALPLPGSY------------VLQDD---KKLLASWTYDYEKKEMISFD--NEQVGHWKGEWIQREGLKGSMFWEASAE Halobacterium_sp_9 YFPGDIP----LDKVTHVNYAFLTVREDG---AVDYIQ--------------------ENAAMRVLEP------------------KSWH--DHT----------------------G-FDDLVD--------DP-ETSFLFSIGGW------------ND---STYFSN-------------------AAQSQASRERFADTAIEI-------MRTHN---------FDGLDID--WEYPGG---GGNSGN-----VVRDGDKQRYTELLQTVRE-KLDVAEDED--GKR----YQLTTALSA-DPE----KNTG------LDHAANAEALDF-LNVMTYDYHGA-FND----YTNHQAPLYGTEADP--------------SPNADEFY---------VDAS--MSFWLDTA-FDPAQLSLGLPFYG-RSFGNVASSDNN--------GLYQP------FDGTP----------------DGT------------------------WGQDNG-------IKEYWDITQNLAPS-------SDYETFWDD----TAKVPWLYSPSKNVLVSYD--SPRSVEAKTAYAAQHDIGGMMFWTFSGD Helicoverpa_VIRUS_73 FPVDKVP----TPNLSHILYGFIPICGGDG-INDSLKSIT----------------GSFEALQRSCAGRDN--FK-------VSIHDPWA--ALQKPQTGV---SAWN---EPYKG-N-FGQLMAAK----LANP-NLKVLASIGGW------------TL---SDPFYH-------------------MHDA-RTRQIFVESVREF-------VLTWK--------FFDGIDID--WEFPGG--KGANPNV-----GDVERDNNTYIALLGELRA-MLDQVQIQT--NRT----LELTTAISA-GID----KIAA------VNYDRAQQYLDK-IFVMSYDFKGA-WSNT---DLGHQTALYGSAW-----------------KPNEPYT---------ANVA--VDALLAQR-VNPKKLVLGVAMYG-RGWTGVHNYNSD-----------NP------FSGVA----------VG--PITGT------------------------W-E-NG-------VVDYRQIAKNIS----------RYEYAFDD----VAKAAYVFDRASGDLISYD--SERSVLAKGEYVLQRRLGGLFAWEIDAD Homo_sapiens_37 ILPHDLD----PFLCTHLIFAFASMNNN----QIVAKD--------------------------------------------------LQ--DE----------------------KILYPEFNKLK----ERNR-ELKTLLSIGGW------------NF---GTSR------------------FTTMLSTFANREKFIASVISL-------LRTHD---------FDGLDLF--FLYPG--LRGSPM-----------HDRWTFLFLIEELLFAFRKEALLTM--RPR----LLLSAAVSGVPHI----VQTS------YDVRFLGRLLDF-INVLSYDLHGS-WER----FTGHNSPLFSLPEDP----------------KSSAY---------------AMNYWRKLG-APSEKLIMGIPTYG-RTFRLLKASKNG------L---QAR------AIGPA---------------SPGKYT----------------------K-Q-EG-------FLAYFEICSFVW----------GAKKHWID----YQYVPYANK--GKEWVGYD--NAISFSYKAWFIRREHFGGAMVWTLDMD Homo_sapiens_39 FMPDNID----PCLCTHLIYAFAGRQNN----EITTIE--------------------------------------------------WN--D-----------------------VTLYQAFNGLK----NKNS-QLKTLLAIGGW------------NF---GTAP------------------FTAMVSTPENRQTFITSVIKF-------LRQYE---------FDGLDFD--WEYPG--SRGSPP-----------QDKHLFTVLVQEMREAFEQEAKQIN--KPR----LMVTAAVAAGISN----IQSG------YEIPQLSQYLDY-IHVMTYDLHGS-WEG----YTGENSPLYKYPTDT----------------GSNAYL----------NVDYVMNYWKDNG-APAEKLIVGFPTYG-HNFILSNPSNTG------I---GAP------TSGAG---------------PAGPYA----------------------K-E-SG-------IWAYYEICTFLKN---------GATQGWDA----PQEVPYAYQ--GNVWVGYD--NIKSFDIKAQWLKHNKFGGAMVWAIDLD Hypocrea_rufa_59 FQPQNLV----ASDITHVIYSFMNFQA-D---GTVVSG------------------DAYADYQKHYDD------------------DSWN--DVGNNAY------------------GCVKQLFKLKK----ANR-NLKVMLSIGGW------------TW---STNFPS-------------------AASTDANRKNFAKTAITF-------MKDW---------GFDGIDVD--WEYPADD-----------------TQASNMVLLLKEIRS-QLDAYAAQYASGYH----FLLSIAAPA-GPE----HYSF------LHMSDLGQVLDY-VNLMAYDYAGS-WST----YSGHDANLFVNPSNP----------------NSSPYN---------TDQA--IKAYINGG-VPSSKIVLGMPIYG-RSF?STGGIG-Q------------T------YSGIG----------------SGS------------------------W-E-NG-------IWDYKVLPKAGAT------------VQYDS----VAQAYYSYDPSSKELISYD--TPDMINKKVSYLKNLGLGGSMFWEASAD Hypocrea_virens_55 HRPQDLP----VDKLTHVLYAFANVRQDS---GEVHMT------------------DGWADTDIHWEG------------------DSWN--DTGNNMY------------------GCLKQLNLLKK----RNR-NLKVLLSIGGW------------TY---SGNFKG-------------------PASTQQGRETFAKSSLEL-------LKNL---------GFDGLDID--WEYPQNA-----------------DEARNFVELLATVRR-ELDAYSATLQNYSH----FELTVACPA-GPT----HFQK------LDVPGMDQYLDF-WNLMAYDYAGS-WDQ----TSGHQANLHPSHDNP----------------TSTPFS---------TDAA--IDFYTRNG-VAPSKIVLGMPIYG-RAFENTDGPG-R------------P------YNGIG----------------EGS------------------------W-E-NG-------IFDYKVLPLQGSQ------------EIYDQ----ATGSSYCYNPQTRKLVSYD--TPHASRVKAGYIKEWGLGGGMWWESSGD Janthinobacterium_lividum_41 YEVANVHTSGVADKLTFINYAFGNIYPKNGGYECGMINKAEPGATNPNSPDTGTGGDAEADYIR--TPKRT--VD-------G-QVIPWD--A-------------------PLSG-N-FLQLKKLK----AAHP-NLKLFISLGGW------------SW---SKNFSV-------------------GSATDALRKQMVRSCIDIYIKGNLPVQGGRGGVGAAANIFDGIDID--WEYPVG--GGQPYN------TVSPNDKRNFTLLMAEFRSQLD-ALGAAN--GKR----YLLTAAVGA-GKD----KIDN------TEPALYSQYMDW-INLMTYDFHGG-WETS----TNFNAQLFADPADP-------------STGMAREYV---------GDKA--VQYMIAAG-VPRDKLLLGIPFYG-RGWTGVAPGPNGD------------------GLYQAA---------TG--TAPGT------------------------Y-E-SG-------IEDYKILVAKAGT------------RYYHP----VTKQLYLYTGAGGQWWSYD--DPTVIGTKVKYVKDQGLRGAFSWELDGD Kluyveromyces_lactis_28 MDPKNIP----NGPYDILHYAFVNIN-SD---FSIDD-------------------------------------------------SAFS--KSA------------------------FLKVTSS------------KKIPSFGGW------------DFSTSP-STYT---------------IFRNAVKTDQNRNTFANNLINF-------MNKYN---------LDGIDLD--WEYPGAPDIPDIPADD-------SSSGSNYLTFLKLLKG-KMPSG-------------KTLSIAIPSSYWY-----LKN------FPISDIQNTVDY-MVYMTYDIHGI-WEYGK---ANSYINCHTPRK------------------EIEDA----------------IKMLDKAG-VKFNKVFGGVANYG-RSYKMVNTNCY------------NY------GCGFQR--------------EGGN-------------------SRDMTN-T-PG-------VLSDSEIIDIDSSD--------K-KNDR??????????????????????????????????????????????????????? Kurthia_zopfii_11 YNVTDID----PTKVTHINYAFADICWNG---VHGNP--D---------------PSGPNPVTWTCQNEKSQTIN--VPNGTIVLGDPWI--DTGKTFA----GDTWD---QPIA--GNINQLNKLK----QINP-NLKTIISVGGW------------TW---SN-RFS------------------DVAATAATREVFANSAVDF-------LRKYN---------FDGVDLD--WEYPVS---GGLD-----GNSKRSGDKQNYTLLLSKIRE-KLDAAGAVD--GKK----YLLTIASGASTTY-----AAN------TELANIASIVDW-INIMTYDFNGA-WQK----VSAHNALLNYDPAAS-------------AAGVPDANT---------FNVAAGAQGHLNAG-VPAAKLVLGVPFYG-RGWDGCAQAGNGQY--------QTC------TGG----------------SSVGTWEA----------GS-------------FD-------FYDLETNYIN----------KNGYTRYWND----TAKVPYLYNASNKRFISYD--DAESIGYKTAYIKSKGLGGAMFWELSGD Listonella_anguillarum_70 YTVDNIP----ADNLTHILYGFIPICGP----NESLKSVG---------------GNSYNALMTACNGVND--YE-------GVS-DPWP--AYQRVFPQG--GHQYS---SPIKG-N-YAMLLALK----RCNP-DLKILPSIGGW------------TL---SDPFFD-------------------FTNK-ANRDTFVASVKKF-------LTTWK--------FYHGVDEL--WEFPGG--GGQAGS------GDPVNDGPAYIALMRELLAPMLDELQSET--GRT----YELTSAIGV-GHD----KIED------VNFMRSIQYMDY-ILAMTYDFYGW-WNN----VLGHQTRLYCGSFMRPGQCDGKGVDENGEPYKGPAYT---------ADNG--IQLLLAQG-VPANKLVLVAAMYG-RGWEGVMPALHKVIP-------TDP------MTGVG----------NG--KLKGTSAQ-------------------GVW-E-AG-------VIDYKGIKSFMLGANN--TGINGFEYGYDA----QAEAPWVWNRTTGQLVTFD--DNRSIKRKGAYARNLGLAGLFSWEIDAD Metarhizium_flavoviride_62 YQPADLP----ASQISHVLYSFLNLSA-N---GTVYSG------------------DTWADIDKHYPN------------------DSWN--DVGNNVY------------------GCAKQLFLLKK----ANR-KMKTMLSIGGW------------TW---STNFPA-------------------AASTAATRSNFAKSAVTI-------MKDW---------GFDGIDVD--WEYPADD-----------------TQATNMVLLLQAVRD-ELDAYAAKFAPGYH----FQLSIAAPA-GAT----NYNK------LHLADLGKVLDY-INLMAYDFSGS-WSN----SSAHNANLYANPSNL----------------NATPFN---------TDDA--VNDYIKGG-VPASKIVLGMPIYG-KSFQKTNGIG-K------------P------FSGIG----------------DGS------------------------W-E-NG-------VWDYKVLPKAGAR------------VIYDD----VAKGYYSYDNRTQELISYD--TPDITKEKVTYLKSKGLGGSMFWEASAD Microbulbifer_degradans_45 YHVKNIHTSGSADKLTHIVYAFGNV--QNG--ECKI-------------------GDSYAAYDKAYSAADS--VD-------G-VADTWD--DG------------------VLRG-N-FGQLRRLK----AMHP-QIKIVWSFGGW------------TW---SGGFGE-------------------AAAN---ADHFANSCYDL-------VFDAR-----WADVFDGIDID--WEYPND--CG--LS------CDN-SGYDGYRVLMQALRNRFG-----------N----KLVTAAIGA-GES----KQNA------ADYGGAAQYLDF-YMLMTYDFFGA-FNPQG--PTAPHSPLYNYPGMP-----------------IEGFS---------SDHG--IQVLKSKG-VPAEKILLGIGFYG-RGWTNVTQDAPG----------------------GSA---------NG--AAPGT------------------------Y-E-KG-------IEDYKVLKNTCP--------------ATGT----IAGTAYAKC--GSNWWGYD--TPATIDSKMDYAKQQGLGGAFFWELSGD Momordica_charantia_16 LPASNID----ATLYTHLFCGYGEIDATSH--EVTIPS---------------------------------------------------T--EVS----------------------H-FSEKVKVS------NP-SVKTLLSIRG-------------D----SKVFSD-------------------IAKVPTARDTFVNSSIKA-------AVDCG---------FDGLDLQ--WLYPSS------P-----------TDMQNFKTLIVKWRQAAVDDARNNN--RPE----RILVASVPNLPYI----EKNVE-----YPGEAIKQNLDW-VNLVCYDFYTPAEGSSPD-YTGPSSALFNR--------------------RSNSLS---------AHFG--IESWTKYV--PAKKIVFGIPFHG-WAWTLANAAEHD-------------------MFSKA----------------TGSCV----------------------W-P-----------MDYSEVKSHRRAR------QCEYNIPNDP----RFGIAYAYV--ETTWIGYE--SESTIPVKIKFAKQNQLLGYFAWNISGD Mus_musculus_38 FKPDDIN----PCLCTHLIYAFAGMQNN----EITTIE--------------------------------------------------WN--D-----------------------VTLYKAFNDLK----NRNS-KLKTLLAIGGW------------NF---GTAP------------------FTTMVSTSQNRQTFITSVIKF-------LRQYG---------FDGLDLD--WEYPG--SRGSPP-----------QDKHLFTVLVKEMREAFEQEAIESN--RPR----LMVTAAVAGGISN----IQAG------YEIPELSKYLDF-IHVMTYDLHGS-WEG----YTGENSPLYKYPTET----------------GSNAYL----------NVDYVMNYWKNNG-APAEKLIVGFPEYG-HTFILRNPSDNG------I---GAP------TSGDG---------------PAGAYT----------------------R-Q-AG-------FWAYYEICTFLRS---------GATEVWDA----SQEVPYAYK--ANEWLGYD--NIKSFSVKAQWLKQNNFGGAMIWAIDLD Neurospora_crassa_27 MLPEQIP----YGYYTDIIFSFATIDPNS---FEIKPG------------------------------------------------DSKT--ADY------------------------MQRISAIK----LIQP-DIRIWIAVGGW------------AFNDPG-PTQT---------------TFSDIAASSANTEKFIDSLVKL-------MNKYG---------FDGIDID--WEYPVAEDRSGRGAD-----------YKNFVTFQKALYD-RMKGGG------LK----KQVSLTLPASYWY-----LQH------FDIVNLEKYVDW-FNVMSYDMHGS-WDIDNK-WTGPYANSHSNMT------------------EIQQA----------------LDLLWRNN-IKPAKVTFGMAFYS-RSFALTSPSCN------------TP------GCPIS---------------SGGN-------------------AGKCSG-T-TG-------VLLHAEIQDEISAR--------K-LTPTLH----REAAVKSVSWG-DQWVTFD--DAATWRLKANIIRGQCIPGVMVWAMSQD Neurospora_crassa_56 HRPQDLP----AEKLTHILYAFANVRPDS---GEVYLT------------------DQWADTDIHWEG------------------DSWN--DSGTNLY------------------GCLKQLNLLKR----RNR-NLKVLLSIGGW------------TY---SSNFKE-------------------PASKEEGRRRFAESAVEL-------VKNL---------GFDGLDID--WEYPQNA-----------------QEASDFVSLLSACRS-ALDAYASTVPGNPH----FEMSVACPA-GPQ----NYEK------MDLPGMDRYLDF-WNLMAYDYAGS-WDQ----VAGHQANLFHCNSNP----------------AATPFS---------TQRA--VEYYLSTG-VAADKIVLGMPLYG-RAFQGTEGLG-Q------------P------YSGVG----------------EGT------------------------W-E-NG-------VHDYKKLPLEGAE------------ERVDY----ESGATYCYHPGTKTLVSYD--TPGMARMKAEYIRERGLGGAMWWESSAD Neurospora_crassa_58 FQPQQLP----ASQITHVLYSFADIKP-D---GQVVSS------------------DTYADLEKRYPG------------------DSWS--EPGENAY------------------GCVKQMYLLKK----RNR-NMKVLLSIGGW------------TY---SPKFPP-------------------VAATEEGRRRFASSAVKL-------VQDW---------GFDGLDID--WEYPTNA-----------------REAQDFVLLLRACRQ-ALDDYARQYAPGYH----FLITIAAPA-GPQ----HYGV------MDLPGMNPYIDS-WHLMAYDYAGS-WDS----TTGHQANLLPSPKNL----------------LTTRFN---------TDQA--VRDFVRRG-IPANKIVLGLPLYG-RSFEGTDGLG-K------------P------YSGIG----------------AGT------------------------L-E-PG-------TWVYRDLPRPGAK------------EEYDN----LAKATYSYDALSRELITYDNVLSALVKTKYIFLR--GLGGAVFWEASGD Nicotiana_tabacum_17 ALN-NID--STLF--THLFCAFADLNPQSN--QLIISP------------------------------------------------ENQD--SFS-Q----------------------FTSTVQRK------NP-SVKTFLSIAGG------------RA---DTTAYG------------------IMARQPNSRKSFIDSSIRL-------ARQFG---------FHGLDLD--WEYPL-----------------SATDMTNLGILLNEWRTAINM----EARNSGRAA--LLLTAAVS-YSPRVN--G-LN------YPVESVARNLNW-INLMAYDFYGPNWSPS---QTNSHAQLFDPVN------------------HISGSD------------G--INAWIQAG-VPTKKLVLGIPFYG-YAWRLVNPNIH---------DLRAP------AAGKSNVG----------AVDDGSMT----------------------Y-N-R---------IRDYIVQSRATT-------------VYNA----TIVGDYCYSGS--NWISYDD-TQSVRNKV-NYVKGRGLLGYFAWHVAGD Nostoc_punctiforme_22 FLPAQID----PSLYTHINFAFGIFGYIT---KGIAPN--------------------NPRLTGDYRIQP----------------IEWN--D-QT---------------------VLYPEIQKLK----LKNP-NLKTLLSIGGWGFNDPQDPIQIGTY---TYNLFS------------------QMAASAAGRQQFIYSALEY-------AQKYK---------FDGIDLD--WEYPGYQGRGGRP-----------EDFANFLALVREFRT-AIS--------GRN----FLLTIASSAIVPSGVPDQYRSNPGSYFQWLAQCAQYLDW-LNVMSYDYHGAFPDDK---VTGMNAPLPQDST------------------PKGPFS---------VKNT--IEAYLAAG-IPNSKIVMGIPTYG-RTFKVSSPLSLTD---------NGPGKS---YSSVG---------------PAGIS-----------------------TVT-PG-------VLSYYEIQNRISS--------GSLTRRWHE----PTLTPYAYNSQTSEWVSYD--DTESIGYKTSYLIEKKLGGAMIWAIGLD Oceanobacillus_itheyensis_10 ?PPQNLD----ANKLTHINYAFADVCWEG---MHGNPD-----------------------NEEIPEGE----------------VKTWPCRDLQGNEADIE--NGSIVLYDYETDLVELPKLKALK----KQNE-NLKTLISIGGW------------TL---SNNLSL-------------------VASTEETRENFAESAVEF-------VREFK---------LDGLDLD--WEYPVA---GGMPNN-----ERDPSDKENHTLLLQEVRD-AFDEAEQED--NKE----YLVTIAGSATWAY-----ADN------NELGAISEIVDY-MAIMAYDINGT-WSE----ITGHNAPLYYSQLEA----------------DVRGWS---------FGVD--STPNVYSA-VPKDKLLLGLPFYG-HSWAGCNADNDG--K-------MVV------ENGAYQ---------T---CAPGWQQP----------G----------V-E-GG-------TVNYNVVKSLINQ--------DGYNYFFDN----EAKVPYLYNEQKGEFISYD--NVESLGYKVNFIEEQGLGGAMIWDLAGD Orygia_VIRUS_75 FPVDKVP----LPNLSHLLYGFIPICGGDG-LNDALKTIP----------------GSFEALQRSCKGRAD--FK-------VAIHDPWA--AIQKPQKGV---SAWN---EPYKG-N-FGQLMAAK----LANP-HLKILPSIGGW------------TL---SDPFYF-------------------MHDA-DKRRVFVESVKEF-------LQVWK--------FFDGVDID--WEFPGG--KGANPAL-----GNGERDADTYLVLLKELRA-MLDELQLQT--NKT----YELTSAISS-GYD----KIAV------VKYDAAQRFLDK-IFLMSYDFKGA-WSNT---DLGYQTTLYAPSW-----------------NANELYT---------TDHA--VKLLTGQG-VAAHKLIVGVAMYG-RGWTGVSGYAGD-----------KY------FSGTA----------DG--PVPGT------------------------W-E-NG-------VVDYRQINNELS----------KYIYRFDA----AAKAAYVFNKERGDLISFD--SVDSVLAKNVYVQQNGLGGLFAWEIDAD Pantoea_agglomerans_80 FTVDKIP----AQNLTHLLYGFIPVCGGDG-INDSLKGVE----------------GSFQALQRSCQGRED--FK-------VSIHDPFA--AVQKGQKGV---TAWD---DPYKG-N-FGQLMALK----QARP-DLKILPSIGGW------------TL---SDPFFF-------------------MGDK-VKRDRFVGSVKEF-------LQTWK--------FFDGVDID--WEFPGG--GGANPKL-----GNAQ-DGATYVQLMKDLRA-MLDQLSAET--GRK----YELTSAISA-GKD----KIDK------VDYNTAQNSMDH-IFLMSYDFYGA-FDLK---NLGHQTALKA--------------------RPGNRHG---------LYHGERRQCVAGQG-VKPGKIVVGAAKYG-RGWTGVSGYQNN-----------NP------FTGTA----------TG--PVKGT------------------------W-E-NG-------IVDYRQIANEFIS--------DEWQYSYDA----TAEAPYVFKPSTGDLITFD--DPRSVQAKGKYVLDKQLGGLFSWEIDAD Pichia_etchellsii_29 MDPLTI-----NG-YDIVHYSFAIIN-SD---LSISVG------------------------------------------------SGFD--D--------------------------FLKITS-------------KKIIAFGGW------------DFSTNP-NTYN---------------ILREVV-SDSKINTFANNVINF-------INEYN---------LDGVNFD--WEYPGAPDIPGIPAGD-------KKDGKRYSDLIGLIKQ-GIGS--------------KLVSVALPAAYWY-----LKA------FPLTDMDKHMDY-FIIMNYDYYGQ-WDYN----TDTGIGCHVDKR------------------NTTDI----------------IKMITKSG-IDTTKVYGGVANYA-RTYKLKDNNCN------------KY------GCDFTG--------------PESNAI-----------------TGDITR-T-PG-------IMTENELLAIDKST--------R-TRWSDT----D------SHCD---IMTYE--DNTNW---AAWMKSSERTNLINWYKDIG Pseudoalteromonas_sp_65 FDVTKVP----GQNLTHILYGFIPICGA----NESLKEIEN--------------GNSWRALQKACGDSQD--YE-------VVIHDPWA--AIQKSLPGV----DAK---DPIRG-T-YSQLMALK----QRYP-DLKILPSVGGW------------TL---SDPFHG-------------------FTEK-ANRDVFVASMKDF-------LKTWK--------FYDGVDID--WEFPGG--GGPNPNL-----GDPAKDGQAYIDLMRELRA-MLDELEAEI--GKP----YQLTSAIGM-GYD----KIED------VNYPQAAQYMDY-IFAMTYDFYGG-WNN----VTGHQTALYCGSHMSTDECNGTGLDDKGEPRKGPAYT---------TDNG--IQLLLQQG-LDPAKIVLGTAMYG-RGWEGVTPANTT-DG-------ANP------MTAPG----------NG--KLTGTTAQ-------------------GVW-E-AG-------VIDYKGIKAHMIGAAE--TGINGFEVGYDE----VAEGAYVWNKSNGKLITYD--SPRSVKAKGQYVRNLGLAGLFAWEIDAD Rhizopus_microsporus_53 YNVVDVAT--QANKLTHILYAFANVQPD----GQVVLG------------------DAYADIEKHFPANQAVNRKE----------DGWN--DPGKNLY------------------GNFKQFYLLKQ----QHR-HLKVSLSIGGY------------TW---STHFGP-------------------VARDPQKRRLFVDSSIKH-------LANL---------GLDGLDID--WEYPKDD-----------------EEAFYYVHLLYELRL-ALDRYQQQCQQLIQSR--LLLTVAVPC-GPD----HYRK------LRLTEMQPYVDL-FYLMAYDYAGS-WDS----FADHQAAVY-----------------------GGRLN---------TEQA--VQHYIACG-IPPYKLVVGMPLYG-RGFCNTAGPG-H------------P------FQGLP----------------RGT------------------------W-E-EG-------QFNYKTLPKPGAV------------EYHD----FNRLASWSYDPQAREFITYD--TPQMVAAKCNYIQQRRLGGAMFWELSAD Sagittula_stellata_68 ???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????VGGW------------TL---SDPFYD-------------------FGVK-ANRDVFVASVKNF-------LQTWK--------FYDGVDID--WEYPGG--QGANPNL-----GDPSKDGDTYAILMAELRT-MLDGLSAET--GRT----YELTSAVGV-GYD----KIED------VNYADAVPHMDY-IFAMTYDYYGG-WNN----VVGHQAALNCGSHMSADECAGKGLDDEGKPRKGPAYT---------TANG--IDLLMAKG-VPANKLVVGAAMYG-RGWTGVTEASMS-DP-------TNP------MTGVG----------NG--KIAGS------------------------W-E-AG-------VIDYKDVVTQYENKA-------GVVVGYDE----VAEAPWAWDPSNGDLVTYD--NKRSVMAKGAYVRSLGLAGLFAWEIDAD Salmonella_enterica_64 ?RKIDK------EDRDVVAEAAALCGKVK---YEPTFL------------------DPWGDFQSYINLGFET--------------SGWD--VDPKTV------------T-QANAKGMLGALRDMQAKAKAAGH-TLALSMSIGGW------------SM---SNGFHE-------------------TAASDSSRKTFAKGVVKL-------FKQFP--------MFSEVDID--WEYPNDEGAGNPFGA---------EDGANYALLIAELRK-QLDSAGLSN---------VKISIAASA-VTT----IFDH------AKVKDLLAAGLYGINLMTYDFFGTPWAE----TLGHHTNRKA----L----------------EEGGWA---------VETI--VDHLLAEG-FSADRINIGYAGYT-RNARQVEIESLS------------P------LKGSYNP---------GSGDTTGS------------------------F-E-SGTSEWYDVIYSYLDLENQKGRNGF--------NVYTDQ----VADADYLYSPESKLFLSLD--TPRTVKAKGEYAAKLGLGGVFTWTIDQD Schewanella_baltica_79 ??????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????RVGGW------------TL---SDPFFY-------------------FGDK-SKRDTFVASVKEF-------LQTWK--------FFDGVDID--WEYPGG--GGANPNL-----GNAN-DGETYVTLMRELRA-MLDELSAET--GRT----YELTSAIGI-DAQ----KMAK------VDYQAAQQYMDY-IFLMSYDFNGG-WTNT---ELGHQTNLYEASW-----------------DPDTRYT---------TDKG--VKALLTQG-VTPGKIVVGAAMYG-RGWTGVNGYTGN-----------NP------FTGTA----------TG--KVKGT------------------------W-E-DG-------IVDYRQIVNEYMG--------SGWTYSYDE----TAEAPSLFKASTGDLITFD--DARSVKAKGQYVLANQLGGLFAWEIDAD Serratia_marcescens_81 FTVDKIP----AQNLTHLLYGFIPICGGNG-INDSLKEIE----------------GSFQALQRSCQGRED--FK-------ISIHDPFA--ALQKAQKGV---TAWD---DPYKG-N-FGQLMALK----QAHP-DLKILPSIGGW------------TL---SDPFFF-------------------MGDK-VKRDRFVGSVKEF-------LQTWK--------FFDGVDID--WEFPGG--KGANPNL-----GSPQ-DGETYVLLMKELRA-MLDQLSAET--GRK----YELTSAISA-GKD----KIDK------VAYNVAQNSMDH-IFLMSYDFYGA-FDLK---NLGHQTALNA--------------------RPGSRHR---------LHHGERRECAAGQG-VKPGKIVVGTAMYG-RGWTGVNGYQNN-----------IP------FTGTH----------R---AVKGT------------------------W-E-NG-------IVDYRQIASQFMS--------GEWQYTYDA----TAEAPYVFKPSTGDLITFD--DARSVQAKGKYVLDKQLGGLFSWEIDAD Sodalis_glossinidius_63 ????DKG-----ANQYKIEQAAAWTGKKQ---YEMTIL------------------DPWGDCQAYFNNGFSSY-------------KDFG--FGPGTTYNGG-SQEDCFKESHPNLQGVLGALLALKKKAALAGH-DLALSFSVGGW------------TM---SEIFHE-------------------MVKSDQAINTFVSSIVDF-------FQRFP--------SFSEIDID--WEYPNAAGAGNPHGP---------EDGANYQKLIAALRQ-AFNSHNRQD---------IKISIASSA-NVD----VLQH------SNIKGLLAAGLYGINVMTYDFFGTPWHE----GLTNHTNLYK----T----------------EHSSYS---------LEEA--VTYLLEQG-VDPDVINVGYAGYS-RSAKGAEISSFS------------P------LKGTYE----------GNDTTVGT------------------------F-E-SGCVEWYDVLYNYLDLENKSGRNGY--------QVYTDD----VACADYLYSPTAKVFHSID--TPRSVREKARYVIEKGLGGIFTWTIDYD Spodoptera_VIRUS_74 FPVDKVP----APNLSHILYGFVPICGGDG-INDALKTVP----------------GSFEALQRSCAGRAD--FK-------VAIHDPWA--AIQKPQKGV---SSWN---EPYKG-N-FGQLMAMK----RANP-HIKVFASIGGW------------TL---SDPFYH-------------------MHDA-DVRRVFIDSVEEF-------LLTWK--------FYDGVHID--WEFPGG--KGANPDV-----GDAERDRETYTLLLQELRL-RLNALGART--NRY----YALTSAVSA-GND----KIAV------VNYTEAQKYLDT-IFLMTYDFKGA-WSNT---ELGHQTALFAPTW-----------------RPDEPYC---------ADRA--VELLLGQH-VPAGKIALGVAMYG-RGWSGVVSDDTD-----------NP------FLGVA----------DG--PVPGT------------------------W-E-AG-------VVDYRQIVHNMS----------QYDYVYDE----VVKGAYVYNRENGNLITYD--DPKSVADKTKYVLDHELAGVFAWEIDAD Stenotrophomonas_maltophilia_43 YRVKNIDTSGSAAKLTHINYAFGNV--RNNRCEVGVTQASDP-----N---TGVGGDAFADYTKAFGAGES--VS-------G-SADTWD--Q-------------------PLRG-N-WNQLKQLK----AKHP-NVKVLISLGGW------------TW---SRGFSS-------------------AAQP-ANRQAFVASCVDAYIKGNLPVTDGAGGVGAAAGVFDGIDID--WEYPVA--CG--LS------CGTPADNANYTALLAEFRRQLD---AVRP--G------LLLTVAVGA-GID----KIRV------TDPAAYHPYLDF-INVMTYDFHGA-WDPQ----TNHHSALFDSPADP-------------STGDQKLYN---------SNDA--MEAFLSRG-VPASKLNLGIGYYG-RGWTGVASGNNG--------------------LYKSA---------GG--AAPGT------------------------Y-E-AG-------IEDWKVLKNLNWP------------VYTDT----VAKATWISN--GTTFWSVD--TPAMVTEKMGYVKAQGLGGAFFWEFSGD Streptomyces_coelicolor_46 YHVKNIESSGSADKLTHINYSFGNV--TGG--KCAM-------------------GDAYAATDRAYTAADS--VD-------G-VADTWD--Q-------------------PLRG-N-FNQLLKLK----QKHP-DLKILWSFGGW------------TW---SGGFAQ-------------------AAQN---PEAFAQSCYDL-------VENSK-----WADVFDGIDID--WEYPNA--CG--LS------CDT-SGRDAFPKLMGALRAKFGQ----------D----YLVTAAITADATAGG--KIDA------ADYAGAAQYVDW-YNPMTYDFFGA-WDATG--PTAPHSPLTSYSGIP-----------------KEDFH---------TSAT--IAKLKGLG-VPSSKLLLGLGFYG-RGWTGVTQADPG----------------------GTA---------NG--PAKGT------------------------Y-E-NG-------IEDYKVLKTSCP--------------ATGT----VGGTAYAKC--GSDWWSYD--TPQTIATKMAYKNEQGLGGTFFWELSGD Streptomyces_coelicolor_49 YHVKNLVTSGSADKITHINYAFGNV--QGG--KCTI-------------------GDSYADYDKAYTADQS--VD-------G-VADTWD--Q-------------------PLRG-N-FNQLRKLK----AKYP-NIKILYSFGGW------------TW---SGGFPD-------------------AVKN---PAAFAKSCHDL-------VEDPR-----WADVFDGIDLD--WEYPNA--CG--LS------CDETSAPNAFSSMMKAMRAEFGQ----------D----YLITAAVTADGSDGG--KIDA------ADYGEASKYIDW-YNVMTYDFFGA-WAKNG--PTAPHSPLTAYDGIP-----------------QQGFN---------TADA--MAKFKSKG-VPADKLLIGIGFYG-RGWTGVTQSAPG----------------------GTA---------TG--PATGT------------------------Y-E-AG-------IEDYKVLKNSCP--------------ATGT----IAGTAYAHC--GSNWWSYD--TPATIKSKMDWAEQQGLGGAFFWEFSGD Streptomyces_coelicolor_6 YLASDIP----WDKITHINYAFAHVDGGN---RLSVG-----------------------------SDGEK--NA--------ATGMTWP--GVE--------GAEMDPG-LPYK--GHFNLLNKFK----KQHP-DVKTMISVGGW------------AE---TGGYFADDGSRVDSGGFYSMATKADGSVNQAGIDTFADSAVDF-------VRKYG---------FNGVDID--YEYPTTMKDAGNPLDWSFANGRRAGLVKGYAALMKTLRE-KLDRAGAAD--GRH----YLLSVAAPSSGYL-----LRG------METFQVQKYLDY-VNIMSYDLHGA-WNE----YVGPNASLFDDGRDA-------------ELAAANVYGSAQYGGIGYLNTDWAYH-YFRGS-MPAGRINIGLPYYT-RGHKNVQGGTDGLWGRASA---STC------PAGSG-----LTKCGDGAVGIDNLWHDLDTNGKESPAGSNPMWHAKNLE-K-GI-------VGDYVTDYGF-PADT---KLTGTYARKYDS----TLVAPWLWNAEKKVFLSTE--DEQSVGAKADYVADRGIGGAMIWELAGD Streptomyces_lividans_48 YHVKNLVTSGSADKITHINYAFGNV--QGG--KCTI-------------------GDSYADYDKAYTADQS--VD-------G-VADTWD--Q-------------------PLRG-N-FNQLRKLK----AKYP-NIKILYSFGGW------------TW---SGGFPD-------------------AVKN---PAAFAKSCHDL-------VEDPR-----WADVFDGIDLD--WEYPNA--CG--LS------CDETSAPNAFSSMMKAMRAEFGQ----------D----YLITAAVTADGSDGG--KIDA------ADYGEASKYIDW-YNVMTYDFFGA-WAKNG--PTAPHSPLTAYDGIP-----------------QQGFN---------TADA--MAKFKSKG-VPADKLLIGIGFYG-RGWTGVTQSAPG----------------------GTA---------TG--PATGT------------------------Y-E-AG-------IEDYKVLKNSCP--------------ATGT----IAGTAYAHC--GSNWWSYD--TPATIKSKMDWAEQQGLGGAFFWEFSGD Streptomyces_olivaceoviridis_7 YLAPDIP----WDKVTHINYAFAHVDGGN---KLSVG-----------------------------ADTAA--NP--------ATGMTWP--GVA--------GAEMDPA-LPYK--GHFNLLNKFK----KQHP-DVKTLISVGGW------------AE---TGGYFGADGKRVDSGGFYSMATNADGSVNRAGIDTFADSAVAF-------VRKYG---------FNGVDID--YEYPTTMKDAGNPLDWSISNGRRAGLVKGYAALMKTLRE-RLDRAGAAD--GKH----YLLSVAAPSSGYL-----LRG------METFQVQKYLDY-VNIMSYDLHGA-WNE----YVGPNASLFDDGKDA-------------ELAAAGVYSTSQYGGIGYLNTDWSYH-YFRGS-MPAGRINIGLPYYT-RGFKNVTGGTDGLWGRAPA---TTC------PAGSG-----LTKCGDGASGIDNLWHDLDTNGKESPAGSNPMWHAKNLE-K-GV-------VGDYVTKYGF-PADT---RLTGTYARKYDA----TLVAPWLWNAEKKVFLSTE--DEQSVNAKADYVVDRGIGGTMVWELAGD Streptomyces_thermoviolaceus_47 FNVKNLDTSGTAAKITHINYAFGNV--TGG--KCAI-------------------GDSYADYDKAFTADQS--VS-------G-QADTWD--Q-------------------PLRA-N-FNQLRQLK----AKYP-HIKVLWSFGGW------------TW---SGGFAD-------------------AAKR---PAAFAQSCYNL-------VHDPR-----WDGVFDGID----WEYPNA--CG--LT------CDS-SGPDAFRNLMAAVRSTFG-----------D----ELVTAAVTADGTPGG--KIEA------TDYAGAAQYVDW-YNVMTYDFFGA-WDAQG--PTAPHSPLTSYDGIP-----------------KQGFT---------SADA--IAAFKAQG-VPADKLLLGIGFYG-RGWTGVTQDAPG----------------------GTA---------TG--PAAGT------------------------W-E-QG-------IEDYKILKNTCP--------------VTGT----VAGTAYAHC--GSNWWIYD--TPDTIASKMAWANDQGLRGAFVWDFSGD Thermococcus_kodakaraensis_8 FYVSDIP----WEKVTHVNYAFLDLKEDG---TVAFY-------------------------------------------------DTYA--DPLN-----------------------LEAMKEYK----RKYP-AVKVLISVGGW------------TL---SKYFSV-------------------VAADPAKRQRFAETAIEI-------LRKYN---------LDGIDID--WEYPGG---GGMAGN-----YESPDDGKNFVLLLKDLRE-ALDKAAKED--HKD----YLLTAATPADPVK-----AGR------IDWVEASKYLDS-INIMTYDYHGA-WET----ITGHLAPLYCDPNAP-------------YTDENVKYH---------FCVNYTVQWYIQHV-PDKTKITVGLPFYS-RSFANVPPENNG---------LYQP------FSGTP----------------AGTWGP--------------------AY-ETYG-------VMDYWDVAEKNQS--------SEYEYHWDP----IAQVAWLYSPSKRIFITFD--DPRAIGIKVDYMLKNGLGGVMIWEITAD Trichoderma_harzianum_60 FQPQNLV----ASDITHVIYSFMNFQA-D---GTVVSG------------------DAYADYQKHYDD------------------DSWN--DVGNNAY------------------GCVKQLFKLKK----ANR-NLKVMLSIGGW------------TW---STNFPS-------------------AASTDANRKNFAKTAITF-------MKDW---------GFDGIDVD--WEYPADD-----------------TQATNMVLLLKEIRS-QLDAYAAQYAPGYH----FLLSIAAPA-GPE----HYSF------LHMSDLGQVLDY-VNLMAYDYAGS-WSS----YSGHDANLFANPSNP----------------NSSPYN---------TDQA--IKDYIKGG-VPASKIVLGMPIYG-RAFESTGGIG-Q------------T------YSGIG----------------SGS------------------------W-E-NG-------IWDYKVLPKAGAT------------VQYDS----VAQAYYSYDPSSKELISFD--TPDMINTKVSYLKNLGLGGSMFWEASAD Ustilago_mayidis_51 YSPLDVP----YCNLTHVLYAFADVNPDT---GECFLT------------------DLWADEQIHYTG------------------DSWN--DTGNNLY------------------GNFKQFLLLKK----KNR-ALKLMLSVGGW------------TF---GPHFAP-------------------MAADAKKRAKFVSTAITI-------LEND---------GLDGIDID--WEYPSDS-----------------TQAANFVLLLKELRA-GLTAHQAKKNETNP----YLLSIAAPC-GPD----HYKV------LQVAKMDQYLDF-WNLMAYDFAGS-WSA----LTGHQANLWN----I----------------KGAPPS---------ADDS--INYYIGQG-VVSHKLVLGIPLYG-RGFENTDGPQ-Q------------P------YRGTG----------------QGT------------------------W-E-AG-------NWDYKFLPVKGAK------------EMIN----TKIAASWSYDSAKREFISYD--TPQNVLLKCQYIRNKRLRGAMFWELSGD Vibrio_cholerae_69 FTVDNIP----GQNLTHILYGFIPICGP----NESLKSVG---------------GNSFNALQTACKGVPD--FE-------VVIHDPWA--AYQKSFPQA--GHQYS---SPIKG-N-YAMLMALK----KTYP-DLKIIPSIGGW------------TL---SDPFFS-------------------FTDK-AKRDVFVASVKRF-------LKTWK--------FYDGVDID--WEYPGG--GGQAADL-----GDPVKDGPAYVALMAELRA-MLDELEAET--GRK----YELTSAIGV-GHD----KIED------VNYGQAVQYMDY-IFAMTYDFYGG-WNN----VLGHQTALYCGSFMRPGQCDGKGVDENGEPYKGPAYT---------TDNG--IQLLLAQG-VPPSKLVVGAAMYG-RGWEGVTPASLK-DP-------NDP------MTGVG----------NG--KLKGTTAQ-------------------GVW-E-AG-------VIDYKGVKNFMLGANK--TGVNGFEYGYDE----QAEAPWVWNRTTGQLVTFD--DDRSVKAKGAYVRNLGLAGLFSWEIDAD Vibrio_parahaemolyticus_5 YLVKDIP----WEQLTHINYAFVSIGSDG---KVNVGD----------------------------VNDPN--NA--------ATGKTWP-------------GVEVDPT-LGFK--GHFGALATYK----QKH--DVKTLISIGGW------------AE---TGGHFDANGDRVADGGFYTMTTNADGSINHAGIEKFAASAVEM-------MRKYK---------FDGLDID--YEYPTSMAGAGNPYDKDFMEPRRQYLWASYQELMKVLRE-KLDAASAQD--GTH----YMLTIAAPSSGYL-----LRG------METFDVTKYLDY-VNIMSYDLHGA-WND----HVGHNAALFDTGKDS-------------ELAQWNVYGTAAYGGIGYLNTDWAYH-YFRGS-MPAGRINIGVPYYT-RGWQGVTGGDNGLWGRAALPNQAEC------QPGTGE--GEKNNCGNGAIGIDNMWHDLDPQGREMGAGSNPMWHAKNLE-K-GI-------WGSYAQAYGLDPVNDPSDKLVGTYTRNYDS----VAVAPWLWNAEKGVFLSTE--DKASIEVKADYVIDKEIGGIMFWELAGD Vibrio_parahaemolyticus_71 YTVDNMP----ADNLTHILYGFIPICGP----NESVKSVG---------------GNSFNALQTACRGVPD--YE-------VVIHDPWA--AYQKSFPQA--GHEYS---TPIKG-N-YAMLMALK----QRNP-DLKIIPSIGGW------------TL---SDPFYD-------------------FVNK-ANRDTFVASVKKF-------LKTWK--------FYDGVDID--WEFPGG--GGAAADK-----GDPVNDGPAYVALMRELRA-MLDELEAET--GRT----YELTSAIGV-GYD----KIED------VNYADAVQYMDY-IFAMTYDFYGG-WNN----VPGHQTALYCGSFMRPGQCDGSGVDENGEAYKGPAYT---------ADNG--IQLLLAQG-VPANKLVLGTAMYG-RGWEGVHQDTLT-DP-------NDP------MTGTA----------TG--KLKGSTAQ-------------------GVW-E-DG-------VIDYKGIKSFMLGANN--TGINGFEYGYDA----QAEAPWVWNRTTGELITFD--DHRSVLAKGSYAKSLGLAGLFSWEIDAD Vibrio_vulnificus_72 YTVDNIP----AQNLTHILYGFIPICGP----NESVKSVG---------------GNSFNALQTACQGVPD--YE-------VVIHDPWA--AYQKSFPQA--GHQYS---TPIKG-N-YAMMMALK----QRYP-DLKIIPSIGGW------------TL---SDPFFD-------------------FVDK-KNRDTFVASVKRF-------LTTWK--------FYDGVDID--WEFPGG--DGAAPNL-----GDPARDGQAYVDLMRELRT-MLNELEAET--GRT----YELTSAIGV-GHD----KIED------VNYADAIQYMDY-IFAMTYDFYGG-WNN----VPGHQTALYCGNFMRPGQCDGTGVDENGVPYKGPAYT---------SDHG--IQLLLAQG-VPANKLVLGTAMYG-RGWEGVMPSTLR-DP-------NDP------MTGTA----------TG--KLKGSTAQ-------------------GVW-E-DG-------VIDYKGIKSFMLGPNS--TGINGFEYGYDD----QAEAPYVWNRTTGELITFD--DHRSVLAKGAYAKSLGLAGLFSWEIDAD ; END;