#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 19, 2025; 0:33 GMT TreeBASE (cc) 1994-2008 Study reference: Lee B., Kim D., Kim H., Kim B., Han H., & Lee J. 2017. Identification of 74 cytochrome P450 genes and co-localized cytochrome P450 genes of the CYP2K, CYP5A, and CYP46A families in the mangrove killifish Kryptolebias marmoratus. BMC Genomics, . TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S22043] BEGIN TAXA; TITLE Taxa; DIMENSIONS NTAX=33; TAXLABELS Danio_rerio_DrCYP2K16 Danio_rerio_DrCYP2K17 Danio_rerio_DrCYP2K18 Danio_rerio_DrCYP2K19 Danio_rerio_DrCYP2K20 Danio_rerio_DrCYP2K21 Danio_rerio_DrCYP2K22 Danio_rerio_DrCYP2K31 Danio_rerio_DrCYP2K6 Danio_rerio_DrCYP2K8 Homo_sapiens_HsCYP2W1 Kryptolebias_marmoratus_Km.CYP2K38 Kryptolebias_marmoratus_Km.CYP2K39 Kryptolebias_marmoratus_Km.CYP2K40 Kryptolebias_marmoratus_Km.CYP2K41 Kryptolebias_marmoratus_Km.CYP2K42 Kryptolebias_marmoratus_Km.CYP2K43 Kryptolebias_marmoratus_Km.CYP2K44 Kryptolebias_marmoratus_Km.CYP2K45 Kryptolebias_marmoratus_Km.CYP2K46 Kryptolebias_marmoratus_Km.CYP2K47 Kryptolebias_marmoratus_Km.CYP2K48 Kryptolebias_marmoratus_Km.CYP2K49 Kryptolebias_marmoratus_Km.CYP2K50 Kryptolebias_marmoratus_Km.CYP2K51 Kryptolebias_marmoratus_Km.CYP2K52 Oryzias_latipes_OlCYP2K27 Oryzias_latipes_OlCYP2K28 Oryzias_latipes_OlCYP2K29 Oryzias_latipes_OlCYP2K30 Takifugu_rubripes_TrCYP2K.like1 Takifugu_rubripes_TrCYP2K.like2 Takifugu_rubripes_TrCYP2K1 ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M45250] TITLE Kryptolebias_Fig._5_CYP_2k; LINK TAXA = Taxa; DIMENSIONS NCHAR=527; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 ] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] Danio_rerio_DrCYP2K16 --MAFLDALLH-VSSTG-TLICFLLLLLVAYLLFLRS---QSDENEPPGPKPLPLLGNLLMLDVNKPHLSLCEMAKQFGPVFKVYFGPKKVVVLAGYKAVKQALVNYAEAFGDREIMPLFH-DFTKGHGIIFANGESWREMRRFALTNLRDFGMGKKKIEEKIIEETCHLREEFEKFEGKPFETAQLMNYAASSVISSIVYGRRFEYTDPQLRTMVDRANESVRLSGSASVQLYNMFPFLGPLLKN-WRQLMKNLHLDIEEISELVNGLHQTLNH-QDLRGFVDSFLVRKQYAEDSGEKDSHFHEQNLIYTVGNLFVAGTDTTSTTLRWSLLLMAKYPHIQDRVQEEIDQVIG-GRQPVSEDRKNLPYTDAVIHETQRLANIVPMSIPHMTSSDITFNGYFIKK------GTCIFPLLTSVLWDEDEWETPHIFNPNHFLDEQGRFVKRDAFMPFSAGRRICLGESLARMELFLFFTSLLQYFRFTPPPGVSEDELELTPAVG--FTLNPIAHKLCAVKRL------ Danio_rerio_DrCYP2K17 ---MVVESLLH-FSSVG-TLLGTLLLLLVFYRLSRDSEF-QKKRKDPPGPKPIPLLGNLLTLDLSRPFDSLCELSKTYGNVYQVFLGPKKVVVLIGHKTVKEALVNFADEFGERDITPIFR-ILANDHGILFSNGESWKEMRRFAISNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFEGKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPRFTEMVDRANENIRVSGSASMMLYNIFPWLGPFLNS-KRTVVRNMLKNRAEFMKLITGLQETLNI-HDRRGFVDSFLIRKQSDEQLGKKDTYFHAENLLMTVGNLFAAGTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDRVIG-GRQPVVEDRKKLPYTDAVIHEIQRLANIVPMNLPHVTSCDVTFNGYFIKK------GTTVIPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFIKRDAFMPFSAGRRVCLGESLARMELFLFFASLLQSYRFTTPPGVSEDELDLKGTVG--VTLNPSPHKLCAIKRF------ Danio_rerio_DrCYP2K18 --MAVVESLLQ-FASTG-TLLGALLLFLVLYLVSSGSGS-QKEGKEPPGPKPLPLLGNLLTLDLTRAFDTFFELSKTYGNIFQVYLGPKKTVVLVGYKTVKEALVNHAEAFGDREIGPSFR-IMNDEHGIVFSNGENWKEMRRFALSNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFEGKPIDTTEPVNYAVSNIISSIVYGSRFEYTDPQFTEMVDRANENVRVGGSISMGLYNMFPWLGPFLKN-KRIVVRNIIQSRVQMTKLITALLETLNP-NDPRGFVDSFLIHKLSDEKSGKKNSYFHNENLMMNVANLFVAGTDTTGTTLRWGLMLTAKYPQIQDRVQEEIDRVIG-GRQPAVEDRKKLPYTDAVIHEIQRFANIVPLNLPHTTSCDITFNGYFIKK------GTTVIPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRDAFMPFSAVILTLMSDARAIE--------------------------------------------------------- Danio_rerio_DrCYP2K19 --MAVVESLLQ-FASTG-TLLAALLLFLVLYLVSSGS---QKEGKEPPGPKPLPLLGNLLTLDLTRAFDTFFELSKTYGNVFQVFLGPRKTVVLVGYKTVKEALVNYAEQFGDREIGPGFR-IMNDEHGILFSNGENWKEMRRFALSNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFEGKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPQFTEMVDRANENVRVGGSVSMWFHEMFPWVGPFLKS-KRIIVENIIQSRAQMTKLITALLETLNP-NDPRGFVDSFLTRKLSDEKSGKKDSYFHEENLIMTVTNLFVAGTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDRVIG-GRQPVVEDRKKLPYTDAVIHEIQRLANIVPLSLPHKTTSDITFNGYFIKK------GTTVVPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRDAFIPFSAGRRVCLGESLARMELFLFFTSLLQSYRFTTPPGVSEDELDLKGIVG--ITLNPSPHKLCAIRRS------ Danio_rerio_DrCYP2K20 --MAVVESLLQ-FASTS-ALLGALLLLLVLYLASSGSTS-QKEGKEPPGPKPLPLVGNLLTLDLTRSFDTFFELSKTYGNIFQVFLGHRKTVVLVGYKTVKEALVNYAEVFGDREIGPGFNDMVLCGSGILFSNGENWKEMRRFALSNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFEGKPFDTTQPVNYAVSNIISSIVYGSRFEYIDPRFTEMVARANENVRVGGSFSMMIYNIFPWLGPFLKN-RAVVVKNITQNRAEKKKLITALLETLNP-HDPRGFVDSFLIHKLSDEKSGKKDSYFHEENLMLTVANLFAAGTDTTGTTLRWGLMLMAKYPHIQDRVQEEIDRVIG-GRQPVVDDRKKLPYTDAVIHEIQRLANIVPLSLPHRTTSDITFNGYFIKK------GTTVVPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRDAFMPFSAGRRVCLGESLARMELFLFFTSLLQSYRFTTPPGVSEDALDLKGIVG--ITLNPSPHKLCAIRRS------ Danio_rerio_DrCYP2K21 --MAVVESLLQ-FASTG-TLLGALLLFLVLYLVSSGSES-QKEGKEPPGPKPLPLVGNLLTLDLTRPFDTFFKLSKTYGNVFQVYLGPEKAVVLVGYKTVKEALVNYAEEFGDREIGPGFS-IMNDEHGILFSNGENWKEMRRFALSNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFEGKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPQFTEMVDRANENVRVGGSISMWLYDIFPWLGPFLKN-KRIIVENIIQSRVQMTKLITALLETLNP-NDPRGFVDSFLIRKLSDEKSGKKDSYFHEENLMMTVTNLFIAGTDTTGTTLRWGLMLMAKYPHIQDRVQEEIDRVIG-GRQPVVEDRKKLPYTDAVIHEIQRLANIVPLSLPHRTTSDITFNGYFIKK------GTTVVPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVRRDAFMPFSAGRRVCLGESLARMELFLFFTSLLQSYRFTTPPGVSEDELDLKGIVG--ITLNPSPHKLCAIRRS------ Danio_rerio_DrCYP2K22 MNMALVGALLPGLSFTVGMVVAFLLLFLVISYFSSS----KDQGKYPPGPKPLPLLGNLHILDLKNTYMSLWKLSKQYGPVYTVHMGPRTVVVLSGYKAVKEALVNLSEEFGERDISPIFQ-DFNEGYGIVFSNGENWKEMRRFALSNLRDFGMGKKRGEELITEEIKYLKEEIERFGGKPFETKLPLAMAISNVIALIVYSIRFEYNSPKFHRAIVRANENAKLVGSPSVQLYNMFPWLRLFVIN-QKRVVDNVQESFKQIGEIVNGLKKTLNP-QSPRGIADKFLIQQQKDKESGKTDSLYNSNNFLTTINNLFGAGIDTTVTTLRWGLLLIAKYPEIQAKVHDEIDSVIG-ERQPVPGDRKNLPYTDAVIHEIQRFADILPIGLLRQTSCDVHLNGYLIKK------GTSVFPLIASVLRDENEWETPDSFNPKHFLNKQGQFVKKDAFMPFGAGRRLCIGESLARMELFLFFTSLLQHFCFTPPPGVSEDELDLTPVVG--FTLSPMPHKLCAVKRF------ Danio_rerio_DrCYP2K31 --MALVGALLPGLSFTVGMVVAVLLLFLFISFFSSS----QDEGKYPPGPKPLPLLGNLHILDLKNTYMSLWKLSKTYGPIYTVHMGPRKVVVLSGYKTVKEALVNLSEEFGDRDISPIFH-DFNQGYGIVFSNGENWKEMRRFALSNLRDFGMGRKRSEELIIEEIKQLKEEFEKFRGKPFETKMPIAMAIANIIALIVYSIRFEYTNTKLHCMIGRAYENARLTGSPSVQLYNMFPWLRPFVAN-QKRIINNVKEAFKQSGEIMNGLKNTLNP-QDPRGIADKFLIRQQMDEDSGKTDTYYNSNNLLSTINNLFGAGTDTTVTTLRWGLLIMAKNPEIQAKVQDEIKRVIG-DRQPVPDDRKNLPYTDAVIHEVQRFADVLPIGSPHQTTCDVHLNGYLIKK------GTSVCPLLASVLRDENEWETPDSFNPKHFLNKQGQFVKKDAFMPFGAGRRLCIGESLARMELFLFFTSLLQHFCFTPPPGVSEDELDLTPVVG--FTLNPIPHKLCAVKRS------ Danio_rerio_DrCYP2K6 MTMALIEAFLLQGS-PTGAILGALLLFLVIYLFSSSSSS-QDKEKYPPGPKPLPLLGNLHILDLKKTYLSLLELSKRYGPIYTVYLGPKKVVILSGYKIVKEALVNLSEEFGDRDISPIFH-DFNRGYGIAFSNGENWREMRRFALSTLRDFGMGRKRSEELIIEEIKYVKEEFEKFGGNPFETKLPLALAISNIIASIVFSVRFEYSNTKLHRMVGRAYENMKLTGSPSVQIYNMFPWLRPIVAN-RNQIVKNLKDTFKQNEELINGVMKTLDP-FNPRGIVDSFLIRQQKDEESGKTDSLYNSNNLYCTVNNLFGAGTDTTVTTLRWGLLLMAKYPEIQAKVQDEIERVIG-GRQPVVEDRKNLPYTDAVIHEIQRFADISPIGAPRQTTCDVHLNGYFIKK------GTPVFPLLVSVLRDEDEWEMPDSFNPKHFLNKQGQFVKKDAFMPFGAGRRVCIGESLARMELFLFFTSLLQYFRFTPPPGVSEDDLDLTPVVG--FTLNPKPHQLCAVKRS------ Danio_rerio_DrCYP2K8 --MAVMETLLMPVSITG-VLLSAVLLFLVVYLISISS---SSPE-DPPGPKPLPLLGNLHTLDLKNLHVSLWELSKKYGPVFKVHLGRKKVVVLAGYKTVKQALVNQAEEFGERDITPIFQ-DCNQGQGIVFANGERWRTMRRFALSTLRDFGMGKKLSEEKIVDETRYLREVFMKFEGQPFDTTQPVNYAVSNIISAIVYGKRFEYEDPAFQDMVNKANMNIRMIGSAVIQIYNMCPFLGPWIKT-WRQLMKNMESTRRQIQTLADVLQETLNP-LDCRGLIDSFLIRKQNIQETGEKDSSFNDQNLLITVSNLFAAGTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDQVLG-GREPVAEDRKNLPYTDAVIHETQRLANILPLNLPHKTSCDVTFNGYFIKK------GTCVLPLLTSVLRDETEWETPDTFNPQHFLDEKGQLIKRDAFMPFSAGRRACLGESLARMELFLFFTSLLQYFRFSPPPGASEDELDLTPVVG--LTLNPSPHKLCAVIRAERQLN- Homo_sapiens_HsCYP2W1 ---------------MALLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQ-LIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFP-LALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQL-HRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDD----PEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLLPK------GTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARA--FTMRPRAQALCAVPRP------ Kryptolebias_marmoratus_Km.CYP2K38 --MELLKDFVFFLFSSPTTVVGGVFLLLVFYFVFVGSTS-GDGRKEPPGPRPLPLLGNLLQLDLSRPYRTLCEFSKNYGSVFTVYFGPRKVVVLAGYETVKEALVSYAEEFGDRDISPIFN-DITRGHGILFSNGDSWKEMRRFALYTLRDFGMGKRVVEEKILEECGHLIQMFENQKGKPFDTAHPLNYATSNIICSVVYGSRYEYNDPRFRNMVSRASENIRLSGSAQIQIYNMFPWLFRWIKN-CQLMLKNVEMTIRDMKAIVTQLKETLDP-QRCRGLVDCFLIQKQRDEDSGVKDTHFHEENLIFTATNLFAAGTETTATTLRWSLLLMAKYPHIQDQVREELLRVIG-NRAARVEDRKNLPFTDAVIHETQRLANIVPMSIPHKTSQDVTFQGYFIKK------DTIVIPLLTSVLHDEREWESPHTFNPSHFLDKEGKFIKRGAFLPFSAGRRVCLGESLAKMELFLFFTSLLQRFHFTPPPGVSEDELDLTPAIG--FTIPPSPHKLCAVSHQ------ Kryptolebias_marmoratus_Km.CYP2K39 ----MLEDIFQSP--TSVSLFGVFVALLLLHLLHS-SFS-SQERREPPGPRPLPVFGNLFQVDLKRPDQSLFNLSKKYGPVFQIYLGLKKVVVLAGYRTVKQALVNQAEEFGNIDISPIIY-DFNQGHGIALANGDSWKEMKRFALTTLRDFGMGKKMSEDLIIEECGYLIKEFEQLEGETFDRSQTIDYASSNVVSALTFGKRFDYEDPIFQTMVERNHETLCLIGSASIQLYNLIPWLGPFLKN-WRDFMKNMEDMKADIRKLITDLKETLDP-EVCRCFIDAFLIRKKHLEDSDIIDSHYHDENLLFSVINFFGAGTETTATTLKWSLLYMAKFPHIQDRVQEELSRVVG-SCQIQIDDRKNLPYTNAVIHETQRFANIGPFSVPHATTKDVTLQGYFIKK------GTTVLTLLTSVLYDENEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACLGESHAKMELFLFFASLLQNFHFIPPPGVSEDDLDLKPVLG--CTLNPKPQQLCAVLRR------ Kryptolebias_marmoratus_Km.CYP2K40 ----MLEDIFQSP--TSVSLFGVFVALLLLHLLYS-SFS-SQKRPEPLGPRPLPVFGNLFQVDLKRLDQSLFNLSKTYGPVFQVYFGPKKVVVLAGYRTVKEALLNQAEEFGNREITPLFY-DFNQGHGIVFSNGDSWKEMRRFALTTLRDFGMGKKMSEEIIIEECGYLIKEMEQYGGEAFNNTQAINYAASNVISALMFKKRFEYKDPVFQTMVEKDNETIRLTGSVSIMIYNLCPWLGPFLKN-WRDMMKNIEANKAHLRKLISDLKETLDP-EICRCFVDAFLIQKKHLKDFDEKSSHYHDENLLYSVMNLFAAGTDTTATTLKWGLLYMAKFPHIQDRVQEELSRVVG-SRQIQTEDRKNLPYTDAVIHETQRFANIGPLAIPHKTTRNVTFQGYFIKK------DTTVFPLLTSVLYDENEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACLGESLAKMELFLFFTSLLQRFHFTPPPGVPEDELDLKPVVG--MTLAPKPQQLCAVRRR------ Kryptolebias_marmoratus_Km.CYP2K41 ----MLEDIFQSP--TSVSLFGVFVALLLLHLLHS-TFS-SQKRPEPPGPRPLPVFGNLFQVDLKRLDQSLFNLSKTYGPVFQVYFGPKKVVVLAGYRTVKEALLNQADEFGNREITPILN-DLTQGHGILFSNGDSWKEMRRFALSTLRDFGMGRKMSEEIIIEECGYLIKEMEQYGGEAFNNTQAINYAASNVISALMFGKRFEYKDPVFQNMVERDNETIHLMGTASIMMYDLFPWLGPFFKN-WRNLMKNNEDSLADLKKLIADLKETLDP-EICRCFVDAFLIRKKHLKDDEVKNSHYHDENLLYTVDDLFAAGTDTTATTLKWGLLYMAKFPHIQRCVQEELSRVVG-SRQVRIEDRKNLPYTDAVIHEIQRFANIAPMALPHTTSNDLTFQGYVVKE------GTTVFPLLTSVLYDESEWESPHSFNPPHFLNDEGKFIRRDAFMPFSAGRRACLGESLAKMELFLFFASLLQHFHFTPPPGVSEDEVDLKPVVG--LTLTPKPQRLCAVHRL------ Kryptolebias_marmoratus_Km.CYP2K42 ----MLEDIFQSP--TTVSLFGVFVALLLLHLLYS-SFS-SQNRPEPPGPRPLPVLGNLFQVDLKTIHHSLFILSKKYGSVFQVRLGPKKVVVLAGYRTVKEALVNQAEAFRNIEITPLFH-DINQGHGIILANGDSWKEMRRFALTTLKDFGMGRKMSEEIIIEECGYLIKEFEQFEGKAFSNTQVISYATSNVISALVFGKRFDYKDPFLNIMMERNYENIRLMSSASIQIYNVIPWIGPLLKN-WRDFKKNIGNSLADIKKIIVDLKKTLDP-EVCRCFVDAFLIHKKQLEDSENRNSHYHDNNLLYSVMNLFGAGTETTATTLKWGLLYLVKFPHIQDRVQEELSRVVG-SRQVRIEDRKNLPYTDAVIHEIQRVANVAP-VLPHTTTKDVTLQGYFLKE------GTTVLLLLLSVLSDESEWESPHSFNPSHFLDDEGKFIRRDAFMPFSTGPRACLGESLARMELFLFFASLLQHFRFTLPPGVSEDELDLKPVEG--FTLGPKPQQLCAVQRQ------ Kryptolebias_marmoratus_Km.CYP2K43 ----MLEDIFQSP--TSVSLFGVFVALLLLHLLHS-TFS-SQNRPEPPGPRPLPVFGNLFQVDLKRLDQSLFNLSKKYGPVFQVYFGPKKVVVLAGYRTVKEALVNQADEFGDRDICPLFY-DLNQEYGILFSNGDSWKEMRRFALSALRDFGMGRKMSEEIIIEECGYLIKEFEQFEGEAFDNTQAINYATSNVISALMFGKRFEYKDPVFQTMVERDNETIHLMGTASLVIYNMIPWMGPFLKN-WTDLMKNMENNKADIRKIIADLKQTLDP-ETCRCFIDAFLIRKNQLEDLEMKSSHYRDENLLYSVINLFAAGTDTTATTLKWSLLYMVRFPQIQDRVQEELSRVVG-SRQVRIEDRKNLPYTDAVIHEIQRLANIVPMALPHATSKDITLQGHLIKE------GTTVFPLLTSVLYDESEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACLGESLAKMELFLFFASLLQHFQFTPPPEVSEDELDLKPVVG--LTLAPKPQKLCAVCRL------ Kryptolebias_marmoratus_Km.CYP2K44 ----MFED-LLSP--ISVSLFGVLVALLLLHLLYS-SFS-SNERPEPPGPRPLPLFGNLFQVDLKWLDKSLFELSKKYGPVFQVYFGPKKVVVLAGYKAVKQALVNQAVEFGNRDITPAFY-DLTKSHGIIFSNGDSWKEMRRFALTALRDFGMGKKMSEEIIIEECHYLIEELEQFEGKAFENTKPFNYAASNVISALIFGRRFDYKDAIFQAMVRRENEIIRLTGSASVWIYNAFPWLAPLLKN-WRDLIKNVKGNETDAMKLIADLKESLDP-EVCRCYVEAFLIHKKQLEDSEMKNLYYHDENLLYCVTNLLEAGNDTTANTVKWGLLHMAKNPHVQDRVQEELSRVVG-SRQIRTEDRKNLPYTDAVIHEIQRLANIFPLALPHATSTDVTFQGYFIKQ------GTTVFPLLTSVLYDESEWESPHSFNPSHFLDKEGNFIKRDALMPFSAGRRACLGESLAKMEVFLFFTSLLQHFHFTPPPGVSEDEVDLTPAVG--FSLCPRPQKLCAVRRK------ Kryptolebias_marmoratus_Km.CYP2K45 ----MFED-LQPP--TSVLLLGVIVALLLLHFFCS-NIF-IQERREPPGPRPLPVFGNLFQVDLKWLDKSLFKLSKKYGPVFQVYFGPKKVVVLAGYRTVKQALVNHAVEFGTREITPTFN-DLHKGHGIAFSNGDSWKEMRRFALTTLRDFGMGKKMSEKIIAKECCYLIEEFEEFEGKAFNNTKPINYAATNVISSLMFGKRFDNKDQVFQAMVERDNEIVRLSGTASLWLYNIFPWLGPFFKN-WRDFMKILEDNEKTVKKIIADLKETLDP-EVCRCFVDAFLIRQKHLEDSEITNLHYHDDNLLYSVMNLFEAGNDTTANTVKWGLLYMAKFPHIQDRVQEELSRVVG-SRQVRTEDRKNLPYTDAVIHETQRLAKNLPVGLPYTTSKNVTFQGYFIRA------GTTVFPLLTSVLYDESEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACIGESLARMELFLFFASLLQHFRFTPPPGVSEDEVDLAPVVG--FSLCPRPQKLCAVRRR------ Kryptolebias_marmoratus_Km.CYP2K46 ----MFED-LQS-----VSLFGVFVALLILHFLYS-SFY-SQETQEPPGPRPVPLFGNLFQMDLRRLNQSLFDLSKKYGPVFQVYFGSQKVVVLSGYRTVKQALVNHANEFGDREITPAFF-DLTKGFGVVFSNGDLWKEMRRFALTTLRDFGMGKKRSEDIIVEECQYVINEFEQLEGKPFDNTKFFNYAATNIVSVLMFGKRFDYKDQVFRAMVERDNELIRLLGTASISVYNCFPWLGPFLKD-WRDYIKHVKASREDVKQIIADMKETLDP-EVCRCFVDAFLIRKKQLEESENS--HFNDDNLLYSVINLIEAGNDTTATTLKWSLLYMAKYPHVQDRVQEELSRVVG-SRQVQSEDRKNLPYTDAVIHETQRFADLVPLALPHTTCQDVTLQGYFIKK------GTTVFPLLTSVLYDENEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACLGEGLARMELFLVFTSLLQRFCFTPPPGVSGDEVDLTPVVG--LTLSPRPQKLCAVQRN------ Kryptolebias_marmoratus_Km.CYP2K47 --MGEVDVFLWSFS--PVSLLVAPVFLLLISLYFSSSFSSQKPRPGPPGPRPLPLLGNLLQLDFKRPDKTFVELSKKYGSVFTFYMGLKKAVVLTGYQTVKEALVNYADEFGERDVPAVAK-EANLNHGIVWSNGDSWKEMRRFALTNLKDFGMGKKACEDKIIEESQSLVQEFKKFKGEAFSTDRIITCAVSNIICSVIYGSRFEYEDPAFQTITNRTSIAVKFSASPKIQFYNLYPGIGKLFISARKKMSDIYAANKKDHLKLLNNLKETLNP-QMCRGVADVFMVPDLHLQESGISNSNYTDENLLATVMNLFAAGTETTTTTLRWSLLYMTKYPKIQAKVQEELNTVVG-SRQVQVQDKQNLPFTNAVIHETQRLANIVPLALAHRTSQDVTFQGHFIEK------GTIVFPVLTTVLHDESEWEKPYDFHPAHFLDKDGNFTKRDAFLPFSAGRRMCPGESLAKMELFIFFTTFLQHFRFTPPPGVSEEDLDLTPLPGGTGTLRPQPHKLCAVSLM------ Kryptolebias_marmoratus_Km.CYP2K48 -------------------------------------MSSKESRKEPPGPTPLPLLGNLLQLDLKKPHETLIEFSKKYGSVFTVHFGPQKVVVLAGYRTVKEALVNHDEAFGVRGPLQIVD-ELNQGHGVLWTNGNTWREMRRFSLTNLKDFGMGRKACEDKIIEECQHLVEVLKNFKGEAFDTNQSLNYAVSNIIASMIYGSRFEYEDLEFTSMVDRINRSGTLLGSPSVQVYNLYPFLFKWIAN-RKESHNVAAANRKQNFALIRHLKQTLNP-QMCRGFVDAFLVHKKKLEESGISDNEFSDDNLVMTVANLFAAGSETTSSTLRWGLLFMAKFPDIQGKVREELKRAVG-DRQVQAADRMNLPYTNAVIHETQRMANILPESLPHKTSRDITFHGHLIRK------GTTVYPLLMSVLRDANEWEKPDTFYPPHFLDKDGKFAKRDAFMPFSAGHRMCLGESLARMELFIFFTTLLQHFRFTPAPGVLEEDLDLTPRTG--LSLTPVPHKLCAVSCM------ Kryptolebias_marmoratus_Km.CYP2K49 --MVVLDGLLQSFC--SASLLVALVVLLTYFLFS-SSFSSKNPSKEPPGPRGLPVLGNLLQIDLKRPHHTFQELSKKYGSVFTVYLGPKKVVVLTGYKTVKEALVQYDEEFGDRDSLPILR-EFNKGHGILWSNGDSWREMRRFTLTNLRDFGMGRKVCEDKIIEECQRLTEVFKNFNGKPFETMQPINYAVSNIICSMVYGSRFEYSDPEFTSMVDRTNRNIQLTGSASIQVYNMFPWLFKWLPT-RKEINETFEMNRNQNFSLFHQLRETLNP-EMCRGVVDAFMVRRQNLEKSGVKNNHFHDDNLFMTVTNLFVAGTETTSTTLRWGLLLMAKYPNIQDQVQEELRRVIG-DRQVQVSDRKNMPFTDAVIHETQRLGNIVPAALPHKTSKDFSFHGYFIKK------DTTVYPLLTSVLNDPAEWEKPHTFHPAHFLDKDGNFVKRDAFMPFSAGRRICLGESLARMELFIFFTTLLQHFTFTPAPGISRDELDLTPVGT--FTLNPSPHKLCAVSRM------ Kryptolebias_marmoratus_Km.CYP2K50 --MGILKAFLRSFS--PTSFLGDVAFLLLIYVCFSFIFSSKTYRHGPPGPKPLPLLGNLLQLDFKRLDRTFVEFSKKYGSVFAIYLGQRKVVILAGYQTVKEAFVNYAEEFGDRDVPIVAK-DTNLDHGIAWVNGDSWKEMRRFALTNLKDFGMGKKACEDKIIEEFHKLIKEFKKFKGEAFDMAQLMNFAVCNIICSMVYGNRFEYGDPEFQTVINKTGESLNLLGTPAIKLYTLFPSLGKLLFSARKKLKTTFEDNKRHHLTLLNRLRETLNP-QMFRGVADVFIAPDLHLQESEISTSNYTDENLLAIVINLFAAGTETTLTTLRWGLLFLTKHPKIQAKVQEELNTVVG-SRQVQVQDKQNLPFTNAVIHEIQRLANIVPLALAHSTSKDVIFQGHFIEK------GTIVFPLLTTVLHDESEWEKPYDFHPAHFLDKDGNFTKRDAFLPFSAGRRICPGESLAKMELFIFFTTFLQHFRFTPPPGVSEEDLDLTALPG--GTLRPQPHKLCAVSLK------ Kryptolebias_marmoratus_Km.CYP2K51 ----MFED-LQSP--TSVLFG-VFVALLLRHLFYS-NFS-SNERQEPPGPRPVPLFGNLFQVDLKRLHQSLFNLSKKYGPVFQVYFGPRKVVVLAGYRMIKQALVNQADEFGTRKMIPAFY-DLSKGHGIVFSNGETWKEMRRFALTTLRDFGMGKKMSEKIIIEECGFLIKEFEQFEGKVFNNTKSINYATTNVISALMFGKRFEYKDQVFQGMVERGNEIIHLVGTASLWIYNIFPWLGPFLKN-WRDFMKILEDNEKTVNKIIADLKETLDT-EVCRCFVDAFLIRQKHLEDSEITNLHYHDENLLYSVTNLLEAGNDTTANTLKWGLLYMAKFPHIQDRVQEELSRVVG-TRQIQTEDRKNLPYTDAVIHETQRLANILPISLLHATSKDITLQGYFIKE------GTAVLPLLTSVLYDESEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACLGESLARMELFLFFTSLLQRFRFTPPPGVSGDEVDLTPVVG--FTLSPRPQKLCAVQRK------ Kryptolebias_marmoratus_Km.CYP2K52 ----MLEDIFQSP--TSVSLFGVFVALLLLHLLHS-TFS-SQKRPEPPGPRPLPVFGNLFQVDLKRLDQSLFNLSKTYGPVFQVYFGPKKVVVLAGYRTVKEALLNQADEFGNREITPIFY-DFSEGHGIVFSNGDSWKEMRRFALSTLKDFGMGRKMSEEIIIEECGYLIKEMEQYGGESFNNTQAISYTASNVISALMFAKRFEYKDPVFQSMVEKDKQNIHLAGSASIMIYNFIPWLGPLLKN-RRTMLKNFIDGRADIWRKIEELKETLDP-EVCRCLVDAFLIRKKQLEDSKIKNSHYHDNNLLYSIQGLFVAGTDTTATTLKWGLLYLTKFPHIQDRIQEKLSRVVG-SCQVRIEDRKNLPYTDAVIHETQRFANIGPLALPHTTTKDVTLQGYFIKK------GTTVLTVLTSVLYDENEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGTLLDLGISL------------------------------------------------------------ Oryzias_latipes_OlCYP2K27 ------MDLLMPLVSSPTTVIGAVFLLLVLYLASAGSTS-RDLGKDPPGPRPLPLLGNLLQLDPRRPHKALCELSKSYGPVFTVYFGIQKVVVLAGYKTVKEALVNNAEEFGDRDITPMFQ-DMNKGHGILFANGESWKELRRFALTTLRDFGMGKRIAEEKILEECDYLIQGLEKHQGNPVDLTCPLNYATSNIISSIVYGSRFDYDDPRFRNLVSRANETIRINGHPLTHLYNMFPRWFRWIKN-RKIILNNVEMTVKDVKDLVKHLKETLNP-SVCRGFVDCFLIKKQKEEDSCVKESHFTEQNLVFSVSNLFAAGTDTTATTLRWGLLLMAKYPHIQDKVHEELAKVLG-GRQVRVDDRKNLPYADAVIHEIQRVANIIPMSIPHKTNRDVTFHGYLIQK------GTTVIPLLASVLNDENEWESPHTFNPHHFLSKEGKFVKRDAFMPFSAGRRACLGESLAKMELFLFFTSLLQRFHFTPPPGVSEEELDLTPAMG--FVLAPSSHELCAVSLQ------ Oryzias_latipes_OlCYP2K28 ----MIQYIFRFMP-ASVSLMWVIVGVLVLLFLYF-QLS-FFNWREPPGPRPLPLLGNLFQVDLKRLDQSLFDLSKKYGPVFVVNFGPKKVVVLAGYRTVKQALVNQAKEFGNREVTPIFY-DFNKEHGILFANGESWNEMRRFALSTLRDFGMGKRISEQNIIEECRWLIEELEKLQGKPFDNTHTISYAVSNVLSGLMFGKRFDYQDPLLQAIVDRDNEIIYLTGTVSILLYNMFPWLGPWLKN-WKTLMKNMEAAKTDMKKIIAELKDTLDP-DTRRCFVDAFLTQKQNLK--EVNGSHYHDDNLLYTVMNLFAAGTDTTATTIEWCLLFMAKYPHIQERVQEELNWVVG-SRQVRIEDRKNLPFTDAVIHESQRLANIAPMAIPHTTSKDVTFQGYFIKK------GTTVLPLLTSVLYDESEWESPRTFNPSHFLDKEGKFLKRGAFMPFSAGRRVCLGESLARMDIFLFFTSLLQHFSFTPPPGVSEDELDLTPVVG--FTLSPQPQGLCAVRRQ------ Oryzias_latipes_OlCYP2K29 --MQILD-FFQSYS--SVSLVGILAVLVLYFISQ-FIFNSEQHGQEPPGPRPLPIIGNLMQIDLKRPYKTLEEFSKTYGPVFTVFFGGEKVVVLAGYKTVKNALVNHDEEFGERAIPPIIQ-ELNKGLGVLWSNGDIWRDIRRFALTNLRDFGMGKKACEDKITEECQYLLEVFKKFKGNAFDTTKPLNYAVSNIICSMVYGSRFEYDDPKFTSMVDRTNRNIQLSGSPTLQAYNMVPWLFKWVAS-RREVHECAAANRKQNQSIFSHLKETLNP-QMCRGFVDAFLVKGQTLEKSGVTNSAFNDENLLMTVIHLFAAGTETTSTTLRWGLLLMAKYPKIQDQVQDELRRVIG-DRMVQVSDRKNLPFTDAVIHEIQRLASIVPTALPHKTSKDVTFQGYFIKK------GTTVFPLLTSVLHDANEWEKPHTFYPAHFLDKDGKFVKREAFIPFSAGRRICLGESLARMELFMFFTTLLQNFCFTPPPGVSKEELSLTPCGG--ITVGPVPHKLCAVPCSE----- Oryzias_latipes_OlCYP2K30 --MGVWDTLLPSLS--PSSLLGAGVLLLLVFLFCPHRTSSQKHRKEPPGPTPIPILGNLHQLDLKRPDQTFMKFAKKYGSVFTVYMGPKKTVVLTGYKTMKEALVNYAEEFGEREAPTVAK-EAHLDCGVVWANGASWREMRRFALSTLRDFGMGKRACEDKIIPECHSLLKEIRKFQGEAFDPTLIINSAVCNVICSMVYGTRFEYDDPDFRTILSRTMKGIQLLGSPGVQLHNLFPRIGRLFLSASKQINQIFTANKNYHLKLL---KETFTP-HTCKSIADAFQLR--QQEEDGFPNSHFHDANILVTIMNLFTAGTETTAATLRWALLFMAKYPKIQDQVQEELSRVME-GRQVTVEDRQRLPFTDAVIHETQRKANIIPLSLLHRTSQDVTFKGFFIEK------GTTVIPVLTSVLYDENEWEKPNIFYPAHFLSKDGKFLKRDAFMPFSAGRRLCLGESLARMELFLFFSTLLQHFRIAPPLGVSEEELDLTPRPG--GTLSPQPHKLCLVSLK------ Takifugu_rubripes_TrCYP2K.like1 ---MSLQDFLLSLG--PSTLMGSVALLLLLCLVSR-SFG-RATRREPPGPRALPLLGNLLQLDLSRPHQTLYQLSKKYGPVFKVHFGPRKVVVLAGHKTVKEALVGNAEQFGDRDISPIFY-DMNQGHGILFSNGETWKEMRRFALSTLRDFGMGKRMIEDKIAEECNYLIQKFEDHEGRAFDTSRLANYATSNIISSIVYGSRFDYDDPRFINMVNRANEVIRLTGSAPIQLYNIFPGLANWIKN-RQLLLKQVAMNFRDMTDLIQQLKDTLNP-GVCRGFVDCFLLRKQKAVDSGVIDSLYNEKNLLYSLSNLFGAGTDTTATTLRWGLLLMAKYPRIQDQVQQELSMVVG-NRRVCVEDRKNLPYVDAVIHEIQRLGNIAPMAVPHKTARDVEFRGYFIEKVKYFSEGTTVFPLLTSVLYDENEWETPHTFNPSHFLDKDGKFIKRDAFMPFSAGRRLCLGEGLAKMEIFLFFTSLLQQFRFTPPPGVGEDELDLTPALG--FTLSPSPHKLCAIPRQ------ Takifugu_rubripes_TrCYP2K.like2 ----MIEDLFESS--TSGFLMVAIVSLLLLQLCFS-FIS-REKRKDLPGPEALPLLGNLHQLDLKRLDCHLVQLSQKYGPIFRVYLASKKVVVLAGYTAVKQALVNQAEDFGEREIFPIFH-DFNKGNGILFTNGDQWKEMRRFALMTLKDFGMGKKIEEK-IIKECQYLIEAFEQHQGEAFSNAQVISYATSNIISAIMYGRRFDYKDPTFQAMIERDHEVIHLTGSPSIQIYNIFPWLGPFLKT-WRYIMKKVEINIESTRRIIGEMKETRNP-GTCRCFVDAFLIHKENQEESDVNAHYYHEDNLLHCAMNLFGAGTDTTATTLQWGLLYITKYPHIQDGVQEELRRVVG-NRQVRVEDRKNLPYMEAVIHETQRMANIVPMSLPHRTSRDRHLLGSICPQ------GTMVIPLLTSVLYDESQWEKPHTFNPAHFLDDEGRFVRRDAFMPFSAGRRMCLGEGLARMELFLFFASLLQHFRFKPAPGVSEDSLDLTPVVG--ITLNPLTHKLRAISRF------ Takifugu_rubripes_TrCYP2K1 --MGIVDLFLQASS--SVSLLGALALLLFVYFISSVSFSSKKDRKCPPGPKPLPILGNLLQFDLKRPYNTLMKLSKTYGSVFTVYLGPKKVVVLAGYKTVKEALIDHAEEFGERDPIMLVQ-NANHEHGVLWSNGESWKEMRRFALTNLRDFGMGKKACENKIIEECSYLMEELKKWKGEPFDTTHPINYAVSNIICSMVYGNRFEYDDPEFTSLVDRTNTLIQISGSPSVLVYDLFPWIG-PLVNNKKLFQSLFAANKKQNLQLFAAAKEMLNP-QMCRSFVDSFLARQQILEKSGT-NVHFHDENLMSTVMNLFNAGTDTTATTLRWGLLLMAKYPLIQDQVQEELRRVIG-SRQVQVEDRKSLPFTDAVIHETQRLANIVPMALPHKTSQDVTLQGFFIEK------GTTVYPLLTSVLYDETEWEKPLNFYPAHFLDKDGKFVKREAFLPFSAGRRICLGEGLAKMELFIFFSTLLQHFRFRPPPGVSEDHLDLTPRVG--LTLNPSAHKLCAVSCL------ ; END;