#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 18, 2025; 21:25 GMT TreeBASE (cc) 1994-2008 Study reference: Lee B., Kim D., Kim H., Kim D., Han H., & Lee J. 2017. Identification of 74 cytochrome P450 genes and co-localized cytochrome P450 genes of the CYP2K, CYP5A, and CYP46A families in the mangrove killifish Kryptolebias marmoratus. BMC Genomics, . TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S22052] BEGIN TAXA; TITLE Taxa; DIMENSIONS NTAX=33; TAXLABELS Danio_rerio_CYP2K16 Danio_rerio_CYP2K17 Danio_rerio_CYP2K18 Danio_rerio_CYP2K19 Danio_rerio_CYP2K20 Danio_rerio_CYP2K21 Danio_rerio_CYP2K22 Danio_rerio_CYP2K31 Danio_rerio_CYP2K6 Danio_rerio_CYP2K8 Homo_sapiens_CYP2W1 Kryptolebias_marmoratus_CYP2K38 Kryptolebias_marmoratus_CYP2K39 Kryptolebias_marmoratus_CYP2K40 Kryptolebias_marmoratus_CYP2K41 Kryptolebias_marmoratus_CYP2K42 Kryptolebias_marmoratus_CYP2K43 Kryptolebias_marmoratus_CYP2K44 Kryptolebias_marmoratus_CYP2K45 Kryptolebias_marmoratus_CYP2K46 Kryptolebias_marmoratus_CYP2K47 Kryptolebias_marmoratus_CYP2K48 Kryptolebias_marmoratus_CYP2K49 Kryptolebias_marmoratus_CYP2K50 Kryptolebias_marmoratus_CYP2K51 Kryptolebias_marmoratus_CYP2K52 Oryzias_latipes_CYP2K27 Oryzias_latipes_CYP2K28 Oryzias_latipes_CYP2K29 Oryzias_latipes_CYP2K30 'Takifugu rubripes CYP2K-like1' 'Takifugu rubripes CYP2K-like2' Takifugu_rubripes_CYP2K1 ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M44213] TITLE Cytochrome_P450_genes_Fig5; LINK TAXA = Taxa; DIMENSIONS NCHAR=785; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y *" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 ] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] Danio_rerio_CYP2K16 ----MAFLDA-LLH-VSSTGTLICFLLLLLVAYLLFLRS--QSDENEPPGPKPLP----LLGNLLMLDVNKPHLSLCEMAKQFGPVFKVYFGPKKVVVLAGYKAVKQALVNYAEAF-------GDREIMPLFH-DFTKGHGIIFANGE----SWREMRRFALTNLR-------DFGMG------KKKIEEKIIEETCHLREEFEKFE------GKPFETAQLMNYAASSVISSIVYGRRFEYTDPQLRTMVDRANESVRLSGSASVQLYNMFP-------FLGPLLKN-WRQLMKNLHLDIEEI---SELVNGLHQTLNHQDLRGFVDSFLVRKQYAEDSGEKDSHFHEQNLIYTVGNLFVAGTDTTSTTLRWSLLLMAKYPHIQDRVQEEIDQVIGGRQPVSEDRK--------------------------------NLPYTDAVIHETQRLANIVPMSIPHMTSSDI----TFNGYFIKK-------GTCIFPLLTSVLWD----EDEWETPHIFNPNHFLDEQGRFVKRDAFMPFSAGRRICLGESLARMELFLFFTS---------------LLQYFRFTPPPGVSEDELELTP-----------------------AVG--FTLNPIAHKLCAVKRL---------------------------------------------------------------------------------------------------------------------------------------------- Danio_rerio_CYP2K17 -----MVVES-LLH-FSSVGTLLGTLLLLLVFYRLSRDSEFQKKRKDPPGPKPIP----LLGNLLTLDLSRPFDSLCELSKTYGNVYQVFLGPKKVVVLIGHKTVKEALVNFADEF-------GERDITPIFR-ILANDHGILFSNGE----SWKEMRRFAISNLR-------DFGMG------KRGSEEKIIEEIHHLKGEFDKFE------GKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPRFTEMVDRANENIRVSGSASMMLYNIFP-------WLGPFLNS-KRTVVRNMLKNRAEF---MKLITGLQETLNIHDRRGFVDSFLIRKQSDEQLGKKDTYFHAENLLMTVGNLFAAGTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDRVIGGRQPVVEDRK--------------------------------KLPYTDAVIHEIQRLANIVPMNLPHVTSCDV----TFNGYFIKK-------GTTVIPLLTSVLKD----ESEWEKPNSFYPEHFLDEKGQFIKRDAFMPFSAGRRVCLGESLARMELFLFFAS---------------LLQSYRFTTPPGVSEDELDLKG-----------------------TVG--VTLNPSPHKLCAIKRF---------------------------------------------------------------------------------------------------------------------------------------------- Danio_rerio_CYP2K18 ----MAVVES-LLQ-FASTGTLLGALLLFLVLYLVSSGSGSQKEGKEPPGPKPLP----LLGNLLTLDLTRAFDTFFELSKTYGNIFQVYLGPKKTVVLVGYKTVKEALVNHAEAF-------GDREIGPSFR-IMNDEHGIVFSNGE----NWKEMRRFALSNLR-------DFGMG------KRGSEEKIIEEIHHLKGEFDKFE------GKPIDTTEPVNYAVSNIISSIVYGSRFEYTDPQFTEMVDRANENVRVGGSISMGLYNMFP-------WLGPFLKN-KRIVVRNIIQSRVQM---TKLITALLETLNPNDPRGFVDSFLIHKLSDEKSGKKNSYFHNENLMMNVANLFVAGTDTTGTTLRWGLMLTAKYPQIQDRVQEEIDRVIGGRQPAVEDRK--------------------------------KLPYTDAVIHEIQRFANIVPLNLPHTTSCDI----TFNGYFIKK-------GTTVIPLLTSVLKD----ESEWEKPNSFYPEHFLDEKGQFVKRDAFMPFSAVILTLMSDARAIE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Danio_rerio_CYP2K19 ----MAVVES-LLQ-FASTGTLLAALLLFLVLYLVSSGS--QKEGKEPPGPKPLP----LLGNLLTLDLTRAFDTFFELSKTYGNVFQVFLGPRKTVVLVGYKTVKEALVNYAEQF-------GDREIGPGFR-IMNDEHGILFSNGE----NWKEMRRFALSNLR-------DFGMG------KRGSEEKIIEEIHHLKGEFDKFE------GKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPQFTEMVDRANENVRVGGSVSMWFHEMFP-------WVGPFLKS-KRIIVENIIQSRAQM---TKLITALLETLNPNDPRGFVDSFLTRKLSDEKSGKKDSYFHEENLIMTVTNLFVAGTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDRVIGGRQPVVEDRK--------------------------------KLPYTDAVIHEIQRLANIVPLSLPHKTTSDI----TFNGYFIKK-------GTTVVPLLTSVLKD----ESEWEKPNSFYPEHFLDEKGQFVKRDAFIPFSAGRRVCLGESLARMELFLFFTS---------------LLQSYRFTTPPGVSEDELDLKG-----------------------IVG--ITLNPSPHKLCAIRRS---------------------------------------------------------------------------------------------------------------------------------------------- Danio_rerio_CYP2K20 ----MAVVES-LLQ-FASTSALLGALLLLLVLYLASSGSTSQKEGKEPPGPKPLP----LVGNLLTLDLTRSFDTFFELSKTYGNIFQVFLGHRKTVVLVGYKTVKEALVNYAEVF-------GDREIGPGFNDMVLCGSGILFSNGE----NWKEMRRFALSNLR-------DFGMG------KRGSEEKIIEEIHHLKGEFDKFE------GKPFDTTQPVNYAVSNIISSIVYGSRFEYIDPRFTEMVARANENVRVGGSFSMMIYNIFP-------WLGPFLKN-RAVVVKNITQNRAEK---KKLITALLETLNPHDPRGFVDSFLIHKLSDEKSGKKDSYFHEENLMLTVANLFAAGTDTTGTTLRWGLMLMAKYPHIQDRVQEEIDRVIGGRQPVVDDRK--------------------------------KLPYTDAVIHEIQRLANIVPLSLPHRTTSDI----TFNGYFIKK-------GTTVVPLLTSVLKD----ESEWEKPNSFYPEHFLDEKGQFVKRDAFMPFSAGRRVCLGESLARMELFLFFTS---------------LLQSYRFTTPPGVSEDALDLKG-----------------------IVG--ITLNPSPHKLCAIRRS---------------------------------------------------------------------------------------------------------------------------------------------- Danio_rerio_CYP2K21 ----MAVVES-LLQ-FASTGTLLGALLLFLVLYLVSSGSESQKEGKEPPGPKPLP----LVGNLLTLDLTRPFDTFFKLSKTYGNVFQVYLGPEKAVVLVGYKTVKEALVNYAEEF-------GDREIGPGFS-IMNDEHGILFSNGE----NWKEMRRFALSNLR-------DFGMG------KRGSEEKIIEEIHHLKGEFDKFE------GKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPQFTEMVDRANENVRVGGSISMWLYDIFP-------WLGPFLKN-KRIIVENIIQSRVQM---TKLITALLETLNPNDPRGFVDSFLIRKLSDEKSGKKDSYFHEENLMMTVTNLFIAGTDTTGTTLRWGLMLMAKYPHIQDRVQEEIDRVIGGRQPVVEDRK--------------------------------KLPYTDAVIHEIQRLANIVPLSLPHRTTSDI----TFNGYFIKK-------GTTVVPLLTSVLKD----ESEWEKPNSFYPEHFLDEKGQFVRRDAFMPFSAGRRVCLGESLARMELFLFFTS---------------LLQSYRFTTPPGVSEDELDLKG-----------------------IVG--ITLNPSPHKLCAIRRS---------------------------------------------------------------------------------------------------------------------------------------------- Danio_rerio_CYP2K22 --MNMALVGALLPGLSFTVGMVVAFLLLFLVISYFSSS---KDQGKYPPGPKPLP----LLGNLHILDLKNTYMSLWKLSKQYGPVYTVHMGPRTVVVLSGYKAVKEALVNLSEEF-------GERDISPIFQ-DFNEGYGIVFSNGE----NWKEMRRFALSNLR-------DFGMG------KKRGEELITEEIKYLKEEIERFG------GKPFETKLPLAMAISNVIALIVYSIRFEYNSPKFHRAIVRANENAKLVGSPSVQLYNMFP-------WLRLFVIN-QKRVVDNVQESFKQI---GEIVNGLKKTLNPQSPRGIADKFLIQQQKDKESGKTDSLYNSNNFLTTINNLFGAGIDTTVTTLRWGLLLIAKYPEIQAKVHDEIDSVIGERQPVPGDRK--------------------------------NLPYTDAVIHEIQRFADILPIGLLRQTSCDV----HLNGYLIKK-------GTSVFPLIASVLRD----ENEWETPDSFNPKHFLNKQGQFVKKDAFMPFGAGRRLCIGESLARMELFLFFTS---------------LLQHFCFTPPPGVSEDELDLTP-----------------------VVG--FTLSPMPHKLCAVKRF---------------------------------------------------------------------------------------------------------------------------------------------- Danio_rerio_CYP2K31 ----MALVGALLPGLSFTVGMVVAVLLLFLFISFFSSS---QDEGKYPPGPKPLP----LLGNLHILDLKNTYMSLWKLSKTYGPIYTVHMGPRKVVVLSGYKTVKEALVNLSEEF-------GDRDISPIFH-DFNQGYGIVFSNGE----NWKEMRRFALSNLR-------DFGMG------RKRSEELIIEEIKQLKEEFEKFR------GKPFETKMPIAMAIANIIALIVYSIRFEYTNTKLHCMIGRAYENARLTGSPSVQLYNMFP-------WLRPFVAN-QKRIINNVKEAFKQS---GEIMNGLKNTLNPQDPRGIADKFLIRQQMDEDSGKTDTYYNSNNLLSTINNLFGAGTDTTVTTLRWGLLIMAKNPEIQAKVQDEIKRVIGDRQPVPDDRK--------------------------------NLPYTDAVIHEVQRFADVLPIGSPHQTTCDV----HLNGYLIKK-------GTSVCPLLASVLRD----ENEWETPDSFNPKHFLNKQGQFVKKDAFMPFGAGRRLCIGESLARMELFLFFTS---------------LLQHFCFTPPPGVSEDELDLTP-----------------------VVG--FTLNPIPHKLCAVKRS---------------------------------------------------------------------------------------------------------------------------------------------- Danio_rerio_CYP2K6 --MTMALIEAFLLQGS-PTGAILGALLLFLVIYLFSSSSSSQDKEKYPPGPKPLP----LLGNLHILDLKKTYLSLLELSKRYGPIYTVYLGPKKVVILSGYKIVKEALVNLSEEF-------GDRDISPIFH-DFNRGYGIAFSNGE----NWREMRRFALSTLR-------DFGMG------RKRSEELIIEEIKYVKEEFEKFG------GNPFETKLPLALAISNIIASIVFSVRFEYSNTKLHRMVGRAYENMKLTGSPSVQIYNMFP-------WLRPIVAN-RNQIVKNLKDTFKQN---EELINGVMKTLDPFNPRGIVDSFLIRQQKDEESGKTDSLYNSNNLYCTVNNLFGAGTDTTVTTLRWGLLLMAKYPEIQAKVQDEIERVIGGRQPVVEDRK--------------------------------NLPYTDAVIHEIQRFADISPIGAPRQTTCDV----HLNGYFIKK-------GTPVFPLLVSVLRD----EDEWEMPDSFNPKHFLNKQGQFVKKDAFMPFGAGRRVCIGESLARMELFLFFTS---------------LLQYFRFTPPPGVSEDDLDLTP-----------------------VVG--FTLNPKPHQLCAVKRS---------------------------------------------------------------------------------------------------------------------------------------------- Danio_rerio_CYP2K8 ----MAVMET-LLMPVSITGVLLSAVLLFLVVYLISISS--SSPE-DPPGPKPLP----LLGNLHTLDLKNLHVSLWELSKKYGPVFKVHLGRKKVVVLAGYKTVKQALVNQAEEF-------GERDITPIFQ-DCNQGQGIVFANGE----RWRTMRRFALSTLR-------DFGMG------KKLSEEKIVDETRYLREVFMKFE------GQPFDTTQPVNYAVSNIISAIVYGKRFEYEDPAFQDMVNKANMNIRMIGSAVIQIYNMCP-------FLGPWIKT-WRQLMKNMESTRRQI---QTLADVLQETLNPLDCRGLIDSFLIRKQNIQETGEKDSSFNDQNLLITVSNLFAAGTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDQVLGGREPVAEDRK--------------------------------NLPYTDAVIHETQRLANILPLNLPHKTSCDV----TFNGYFIKK-------GTCVLPLLTSVLRD----ETEWETPDTFNPQHFLDEKGQLIKRDAFMPFSAGRRACLGESLARMELFLFFTS---------------LLQYFRFSPPPGASEDELDLTP-----------------------VVG--LTLNPSPHKLCAVIRAERQLN----------------------------------------------------------------------------------------------------------------------------------------- Homo_sapiens_CYP2W1 QPRPHGPAALAVPGPPGALGAALRLRPRPLPSCPVAPGASPAAARREPALAASVATGPVPDGALRTLRAGVHRAPGAPEDGGADGVRGGQRGAGGPRAGAGRPASHRHLPAHPARWRHLLLIWGALEGCPPVHGACPAQPGRGPGAGG*QDSAGAEMPLWAAGWLQRPALPAGPTGLGSLQYHLRAPLRPPI*LPGPRVCVPAGSHR*GHGPLGVPWPAAVQRLPMARGPAPAAPARPAQDRGGPCHSEDPPGGAEAPRVPGGPRVQLCGRPDPAGTGG*PRGPVC*GQRGGLHPGHGHGRDGDDLGHAAVGRTSDGPAPGRAGPGAGGARPRAGPWADSPAGGPAGSALHKRRAPRGAAVHHAPAARAPLHRGRHTAGRLPAPQGHARDSPADLGAPG*DTVADPRPVQPRPFPGREWALCEAGGLPAFLCRPPRLCWGAPGQDRALPAVCRPPAEVPPAAPAWRQSGLPGHHARPGFYHEAEGPGPVCGAQALGAPPAPRSS*PLPSQPWVLPPSLLPPHSSDCSGRALRTPTLTPTPTGSATASGYTQDYPCPTLWDPHPSDAVCSSVPASPQERLQGPAHSPTPEAALPPT*LPPGPPSTYSWGCRETTGGCIQPETGAGGCPQRASPAPPRSWDSCRPHSIPAPGTLPAAVPGGSRPAVPDSEPSHWGHAYDWCREARPTFSFRDRHWRQRLPWGGGRAPQPLKTSSTAVAKMETLTRCGGSCL*SQHFGRPRQANHEVRSSRPACPTW*NPVSTKNTKKLTEKKKKKKKKKKKKKKKK- Kryptolebias_marmoratus_CYP2K38 ----MELLKDFVFFLFSSPTTVVGGVFLLLVFYFVFVGSTSGDGRKEPPGPRPLP----LLGNLLQLDLSRPYRTLCEFSKNYGSVFTVYFGPRKVVVLAGYETVKEALVSYAEEF-------GDRDISPIFN-DITRGHGILFSNGD----SWKEMRRFALYTLR-------DFGMG------KRVVEEKILEECGHLIQMFENQK------GKPFDTAHPLNYATSNIICSVVYGSRYEYNDPRFRNMVSRASENIRLSGSAQIQIYNMFP-------WLFRWIKN-CQLMLKNVEMTIRDM---KAIVTQLKETLDPQRCRGLVDCFLIQKQRDEDSGVKDTHFHEENLIFTATNLFAAGTETTATTLRWSLLLMAKYPHIQDQVREELLRVIGNRAARVEDRK--------------------------------NLPFTDAVIHETQRLANIVPMSIPHKTSQDV----TFQGYFIKK-------DTIVIPLLTSVLHD----EREWESPHTFNPSHFLDKEGKFIKRGAFLPFSAGRRVCLGESLAKMELFLFFTS---------------LLQRFHFTPPPGVSEDELDLTP-----------------------AIG--FTIPPSPHKLCAVSHQ---------------------------------------------------------------------------------------------------------------------------------------------- Kryptolebias_marmoratus_CYP2K39 ------MLEDIFQSP--TSVSLFGVFVALLLLHLLHS-SFSSQERREPPGPRPLP----VFGNLFQVDLKRPDQSLFNLSKKYGPVFQIYLGLKKVVVLAGYRTVKQALVNQAEEF-------GNIDISPIIY-DFNQGHGIALANGD----SWKEMKRFALTTLR-------DFGMG------KKMSEDLIIEECGYLIKEFEQLE------GETFDRSQTIDYASSNVVSALTFGKRFDYEDPIFQTMVERNHETLCLIGSASIQLYNLIP-------WLGPFLKN-WRDFMKNMEDMKADI---RKLITDLKETLDPEVCRCFIDAFLIRKKHLEDSDIIDSHYHDENLLFSVINFFGAGTETTATTLKWSLLYMAKFPHIQDRVQEELSRVVGSCQIQIDDRK--------------------------------NLPYTNAVIHETQRFANIGPFSVPHATTKDV----TLQGYFIKK-------GTTVLTLLTSVLYD----ENEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACLGESHAKMELFLFFAS---------------LLQNFHFIPPPGVSEDDLDLKP-----------------------VLG--CTLNPKPQQLCAVLRR---------------------------------------------------------------------------------------------------------------------------------------------- Kryptolebias_marmoratus_CYP2K40 ------MLEDIFQSP--TSVSLFGVFVALLLLHLLYS-SFSSQKRPEPLGPRPLP----VFGNLFQVDLKRLDQSLFNLSKTYGPVFQVYFGPKKVVVLAGYRTVKEALLNQAEEF-------GNREITPLFY-DFNQGHGIVFSNGD----SWKEMRRFALTTLR-------DFGMG------KKMSEEIIIEECGYLIKEMEQYG------GEAFNNTQAINYAASNVISALMFKKRFEYKDPVFQTMVEKDNETIRLTGSVSIMIYNLCP-------WLGPFLKN-WRDMMKNIEANKAHL---RKLISDLKETLDPEICRCFVDAFLIQKKHLKDFDEKSSHYHDENLLYSVMNLFAAGTDTTATTLKWGLLYMAKFPHIQDRVQEELSRVVGSRQIQTEDRK--------------------------------NLPYTDAVIHETQRFANIGPLAIPHKTTRNV----TFQGYFIKK-------DTTVFPLLTSVLYD----ENEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACLGESLAKMELFLFFTS---------------LLQRFHFTPPPGVPEDELDLKP-----------------------VVG--MTLAPKPQQLCAVRRR---------------------------------------------------------------------------------------------------------------------------------------------- Kryptolebias_marmoratus_CYP2K41 ------MLEDIFQSP--TSVSLFGVFVALLLLHLLHS-TFSSQKRPEPPGPRPLP----VFGNLFQVDLKRLDQSLFNLSKTYGPVFQVYFGPKKVVVLAGYRTVKEALLNQADEF-------GNREITPILN-DLTQGHGILFSNGD----SWKEMRRFALSTLR-------DFGMG------RKMSEEIIIEECGYLIKEMEQYG------GEAFNNTQAINYAASNVISALMFGKRFEYKDPVFQNMVERDNETIHLMGTASIMMYDLFP-------WLGPFFKN-WRNLMKNNEDSLADL---KKLIADLKETLDPEICRCFVDAFLIRKKHLKDDEVKNSHYHDENLLYTVDDLFAAGTDTTATTLKWGLLYMAKFPHIQRCVQEELSRVVGSRQVRIEDRK--------------------------------NLPYTDAVIHEIQRFANIAPMALPHTTSNDL----TFQGYVVKE-------GTTVFPLLTSVLYD----ESEWESPHSFNPPHFLNDEGKFIRRDAFMPFSAGRRACLGESLAKMELFLFFAS---------------LLQHFHFTPPPGVSEDEVDLKP-----------------------VVG--LTLTPKPQRLCAVHRL---------------------------------------------------------------------------------------------------------------------------------------------- Kryptolebias_marmoratus_CYP2K42 ------MLEDIFQSP--TTVSLFGVFVALLLLHLLYS-SFSSQNRPEPPGPRPLP----VLGNLFQVDLKTIHHSLFILSKKYGSVFQVRLGPKKVVVLAGYRTVKEALVNQAEAF-------RNIEITPLFH-DINQGHGIILANGD----SWKEMRRFALTTLK-------DFGMG------RKMSEEIIIEECGYLIKEFEQFE------GKAFSNTQVISYATSNVISALVFGKRFDYKDPFLNIMMERNYENIRLMSSASIQIYNVIP-------WIGPLLKN-WRDFKKNIGNSLADI---KKIIVDLKKTLDPEVCRCFVDAFLIHKKQLEDSENRNSHYHDNNLLYSVMNLFGAGTETTATTLKWGLLYLVKFPHIQDRVQEELSRVVGSRQVRIEDRK--------------------------------NLPYTDAVIHEIQRVANVAP-VLPHTTTKDV----TLQGYFLKE-------GTTVLLLLLSVLSD----ESEWESPHSFNPSHFLDDEGKFIRRDAFMPFSTGPRACLGESLARMELFLFFAS---------------LLQHFRFTLPPGVSEDELDLKP-----------------------VEG--FTLGPKPQQLCAVQRQ---------------------------------------------------------------------------------------------------------------------------------------------- Kryptolebias_marmoratus_CYP2K43 ------MLEDIFQSP--TSVSLFGVFVALLLLHLLHS-TFSSQNRPEPPGPRPLP----VFGNLFQVDLKRLDQSLFNLSKKYGPVFQVYFGPKKVVVLAGYRTVKEALVNQADEF-------GDRDICPLFY-DLNQEYGILFSNGD----SWKEMRRFALSALR-------DFGMG------RKMSEEIIIEECGYLIKEFEQFE------GEAFDNTQAINYATSNVISALMFGKRFEYKDPVFQTMVERDNETIHLMGTASLVIYNMIP-------WMGPFLKN-WTDLMKNMENNKADI---RKIIADLKQTLDPETCRCFIDAFLIRKNQLEDLEMKSSHYRDENLLYSVINLFAAGTDTTATTLKWSLLYMVRFPQIQDRVQEELSRVVGSRQVRIEDRK--------------------------------NLPYTDAVIHEIQRLANIVPMALPHATSKDI----TLQGHLIKE-------GTTVFPLLTSVLYD----ESEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACLGESLAKMELFLFFAS---------------LLQHFQFTPPPEVSEDELDLKP-----------------------VVG--LTLAPKPQKLCAVCRL---------------------------------------------------------------------------------------------------------------------------------------------- Kryptolebias_marmoratus_CYP2K44 ------MFED-LLSP--ISVSLFGVLVALLLLHLLYS-SFSSNERPEPPGPRPLP----LFGNLFQVDLKWLDKSLFELSKKYGPVFQVYFGPKKVVVLAGYKAVKQALVNQAVEF-------GNRDITPAFY-DLTKSHGIIFSNGD----SWKEMRRFALTALR-------DFGMG------KKMSEEIIIEECHYLIEELEQFE------GKAFENTKPFNYAASNVISALIFGRRFDYKDAIFQAMVRRENEIIRLTGSASVWIYNAFP-------WLAPLLKN-WRDLIKNVKGNETDA---MKLIADLKESLDPEVCRCYVEAFLIHKKQLEDSEMKNLYYHDENLLYCVTNLLEAGNDTTANTVKWGLLHMAKNPHVQDRVQEELSRVVGSRQIRTEDRK--------------------------------NLPYTDAVIHEIQRLANIFPLALPHATSTDV----TFQGYFIKQ-------GTTVFPLLTSVLYD----ESEWESPHSFNPSHFLDKEGNFIKRDALMPFSAGRRACLGESLAKMEVFLFFTS---------------LLQHFHFTPPPGVSEDEVDLTP-----------------------AVG--FSLCPRPQKLCAVRRK---------------------------------------------------------------------------------------------------------------------------------------------- Kryptolebias_marmoratus_CYP2K45 ------MFED-LQPP--TSVLLLGVIVALLLLHFFCS-NIFIQERREPPGPRPLP----VFGNLFQVDLKWLDKSLFKLSKKYGPVFQVYFGPKKVVVLAGYRTVKQALVNHAVEF-------GTREITPTFN-DLHKGHGIAFSNGD----SWKEMRRFALTTLR-------DFGMG------KKMSEKIIAKECCYLIEEFEEFE------GKAFNNTKPINYAATNVISSLMFGKRFDNKDQVFQAMVERDNEIVRLSGTASLWLYNIFP-------WLGPFFKN-WRDFMKILEDNEKTV---KKIIADLKETLDPEVCRCFVDAFLIRQKHLEDSEITNLHYHDDNLLYSVMNLFEAGNDTTANTVKWGLLYMAKFPHIQDRVQEELSRVVGSRQVRTEDRK--------------------------------NLPYTDAVIHETQRLAKNLPVGLPYTTSKNV----TFQGYFIRA-------GTTVFPLLTSVLYD----ESEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACIGESLARMELFLFFAS---------------LLQHFRFTPPPGVSEDEVDLAP-----------------------VVG--FSLCPRPQKLCAVRRR---------------------------------------------------------------------------------------------------------------------------------------------- Kryptolebias_marmoratus_CYP2K46 ------MFED-LQS-----VSLFGVFVALLILHFLYS-SFYSQETQEPPGPRPVP----LFGNLFQMDLRRLNQSLFDLSKKYGPVFQVYFGSQKVVVLSGYRTVKQALVNHANEF-------GDREITPAFF-DLTKGFGVVFSNGD----LWKEMRRFALTTLR-------DFGMG------KKRSEDIIVEECQYVINEFEQLE------GKPFDNTKFFNYAATNIVSVLMFGKRFDYKDQVFRAMVERDNELIRLLGTASISVYNCFP-------WLGPFLKD-WRDYIKHVKASREDV---KQIIADMKETLDPEVCRCFVDAFLIRKKQLEESENS--HFNDDNLLYSVINLIEAGNDTTATTLKWSLLYMAKYPHVQDRVQEELSRVVGSRQVQSEDRK--------------------------------NLPYTDAVIHETQRFADLVPLALPHTTCQDV----TLQGYFIKK-------GTTVFPLLTSVLYD----ENEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACLGEGLARMELFLVFTS---------------LLQRFCFTPPPGVSGDEVDLTP-----------------------VVG--LTLSPRPQKLCAVQRN---------------------------------------------------------------------------------------------------------------------------------------------- Kryptolebias_marmoratus_CYP2K47 -----MGEVDVFLWSFSPVSLLVAPVFLLLISLYFSSSFSSQKPRPGPPGPRPLP----LLGNLLQLDFKRPDKTFVELSKKYGSVFTFYMGLKKAVVLTGYQTVKEALVNYADEF-------GERDVPAVAK-EANLNHGIVWSNGD----SWKEMRRFALTNLK-------DFGMG------KKACEDKIIEESQSLVQEFKKFK------GEAFSTDRIITCAVSNIICSVIYGSRFEYEDPAFQTITNRTSIAVKFSASPKIQFYNLYP-------GIGKLFISARKKMSDIYAANKKDH---LKLLNNLKETLNPQMCRGVADVFMVPDLHLQESGISNSNYTDENLLATVMNLFAAGTETTTTTLRWSLLYMTKYPKIQAKVQEELNTVVGSRQVQVQDKQ--------------------------------NLPFTNAVIHETQRLANIVPLALAHRTSQDV----TFQGHFIEK-------GTIVFPVLTTVLHD----ESEWEKPYDFHPAHFLDKDGNFTKRDAFLPFSAGRRMCPGESLAKMELFIFFTT---------------FLQHFRFTPPPGVSEEDLDLTP-----------------------LPGGTGTLRPQPHKLCAVSLM---------------------------------------------------------------------------------------------------------------------------------------------- Kryptolebias_marmoratus_CYP2K48 --------------------------------------MSSKESRKEPPGPTPLP----LLGNLLQLDLKKPHETLIEFSKKYGSVFTVHFGPQKVVVLAGYRTVKEALVNHDEAF-------GVRGPLQIVD-ELNQGHGVLWTNGN----TWREMRRFSLTNLK-------DFGMG------RKACEDKIIEECQHLVEVLKNFK------GEAFDTNQSLNYAVSNIIASMIYGSRFEYEDLEFTSMVDRINRSGTLLGSPSVQVYNLYP-------FLFKWIAN-RKESHNVAAANRKQN---FALIRHLKQTLNPQMCRGFVDAFLVHKKKLEESGISDNEFSDDNLVMTVANLFAAGSETTSSTLRWGLLFMAKFPDIQGKVREELKRAVGDRQVQAADRM--------------------------------NLPYTNAVIHETQRMANILPESLPHKTSRDI----TFHGHLIRK-------GTTVYPLLMSVLRD----ANEWEKPDTFYPPHFLDKDGKFAKRDAFMPFSAGHRMCLGESLARMELFIFFTT---------------LLQHFRFTPAPGVLEEDLDLTP-----------------------RTG--LSLTPVPHKLCAVSCM---------------------------------------------------------------------------------------------------------------------------------------------- Kryptolebias_marmoratus_CYP2K49 -----MVVLDGLLQSFCSASLLVALVVLLTYFLFS-SSFSSKNPSKEPPGPRGLP----VLGNLLQIDLKRPHHTFQELSKKYGSVFTVYLGPKKVVVLTGYKTVKEALVQYDEEF-------GDRDSLPILR-EFNKGHGILWSNGD----SWREMRRFTLTNLR-------DFGMG------RKVCEDKIIEECQRLTEVFKNFN------GKPFETMQPINYAVSNIICSMVYGSRFEYSDPEFTSMVDRTNRNIQLTGSASIQVYNMFP-------WLFKWLPT-RKEINETFEMNRNQN---FSLFHQLRETLNPEMCRGVVDAFMVRRQNLEKSGVKNNHFHDDNLFMTVTNLFVAGTETTSTTLRWGLLLMAKYPNIQDQVQEELRRVIGDRQVQVSDRK--------------------------------NMPFTDAVIHETQRLGNIVPAALPHKTSKDF----SFHGYFIKK-------DTTVYPLLTSVLND----PAEWEKPHTFHPAHFLDKDGNFVKRDAFMPFSAGRRICLGESLARMELFIFFTT---------------LLQHFTFTPAPGISRDELDLTP-----------------------VGT--FTLNPSPHKLCAVSRM---------------------------------------------------------------------------------------------------------------------------------------------- Kryptolebias_marmoratus_CYP2K50 -----MGILKAFLRSFSPTSFLGDVAFLLLIYVCFSFIFSSKTYRHGPPGPKPLP----LLGNLLQLDFKRLDRTFVEFSKKYGSVFAIYLGQRKVVILAGYQTVKEAFVNYAEEF-------GDRDVPIVAK-DTNLDHGIAWVNGD----SWKEMRRFALTNLK-------DFGMG------KKACEDKIIEEFHKLIKEFKKFK------GEAFDMAQLMNFAVCNIICSMVYGNRFEYGDPEFQTVINKTGESLNLLGTPAIKLYTLFP-------SLGKLLFSARKKLKTTFEDNKRHH---LTLLNRLRETLNPQMFRGVADVFIAPDLHLQESEISTSNYTDENLLAIVINLFAAGTETTLTTLRWGLLFLTKHPKIQAKVQEELNTVVGSRQVQVQDKQ--------------------------------NLPFTNAVIHEIQRLANIVPLALAHSTSKDV----IFQGHFIEK-------GTIVFPLLTTVLHD----ESEWEKPYDFHPAHFLDKDGNFTKRDAFLPFSAGRRICPGESLAKMELFIFFTT---------------FLQHFRFTPPPGVSEEDLDLTA-----------------------LPG--GTLRPQPHKLCAVSLK---------------------------------------------------------------------------------------------------------------------------------------------- Kryptolebias_marmoratus_CYP2K51 ------MFED-LQSP--TSVLFG-VFVALLLRHLFYS-NFSSNERQEPPGPRPVP----LFGNLFQVDLKRLHQSLFNLSKKYGPVFQVYFGPRKVVVLAGYRMIKQALVNQADEF-------GTRKMIPAFY-DLSKGHGIVFSNGE----TWKEMRRFALTTLR-------DFGMG------KKMSEKIIIEECGFLIKEFEQFE------GKVFNNTKSINYATTNVISALMFGKRFEYKDQVFQGMVERGNEIIHLVGTASLWIYNIFP-------WLGPFLKN-WRDFMKILEDNEKTV---NKIIADLKETLDTEVCRCFVDAFLIRQKHLEDSEITNLHYHDENLLYSVTNLLEAGNDTTANTLKWGLLYMAKFPHIQDRVQEELSRVVGTRQIQTEDRK--------------------------------NLPYTDAVIHETQRLANILPISLLHATSKDI----TLQGYFIKE-------GTAVLPLLTSVLYD----ESEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACLGESLARMELFLFFTS---------------LLQRFRFTPPPGVSGDEVDLTP-----------------------VVG--FTLSPRPQKLCAVQRK---------------------------------------------------------------------------------------------------------------------------------------------- Kryptolebias_marmoratus_CYP2K52 ------MLEDIFQSP--TSVSLFGVFVALLLLHLLHS-TFSSQKRPEPPGPRPLP----VFGNLFQVDLKRLDQSLFNLSKTYGPVFQVYFGPKKVVVLAGYRTVKEALLNQADEF-------GNREITPIFY-DFSEGHGIVFSNGD----SWKEMRRFALSTLK-------DFGMG------RKMSEEIIIEECGYLIKEMEQYG------GESFNNTQAISYTASNVISALMFAKRFEYKDPVFQSMVEKDKQNIHLAGSASIMIYNFIP-------WLGPLLKN-RRTMLKNFIDGRADI---WRKIEELKETLDPEVCRCLVDAFLIRKKQLEDSKIKNSHYHDNNLLYSIQGLFVAGTDTTATTLKWGLLYLTKFPHIQDRIQEKLSRVVGSCQVRIEDRK--------------------------------NLPYTDAVIHETQRFANIGPLALPHTTTKDV----TLQGYFIKK-------GTTVLTVLTSVLYD----ENEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGTLLDLGISL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Oryzias_latipes_CYP2K27 --------MDLLMPLVSSPTTVIGAVFLLLVLYLASAGSTSRDLGKDPPGPRPLP----LLGNLLQLDPRRPHKALCELSKSYGPVFTVYFGIQKVVVLAGYKTVKEALVNNAEEF-------GDRDITPMFQ-DMNKGHGILFANGE----SWKELRRFALTTLR-------DFGMG------KRIAEEKILEECDYLIQGLEKHQ------GNPVDLTCPLNYATSNIISSIVYGSRFDYDDPRFRNLVSRANETIRINGHPLTHLYNMFP-------RWFRWIKN-RKIILNNVEMTVKDV---KDLVKHLKETLNPSVCRGFVDCFLIKKQKEEDSCVKESHFTEQNLVFSVSNLFAAGTDTTATTLRWGLLLMAKYPHIQDKVHEELAKVLGGRQVRVDDRK--------------------------------NLPYADAVIHEIQRVANIIPMSIPHKTNRDV----TFHGYLIQK-------GTTVIPLLASVLND----ENEWESPHTFNPHHFLSKEGKFVKRDAFMPFSAGRRACLGESLAKMELFLFFTS---------------LLQRFHFTPPPGVSEEELDLTP-----------------------AMG--FVLAPSSHELCAVSLQ---------------------------------------------------------------------------------------------------------------------------------------------- Oryzias_latipes_CYP2K28 ------MIQYIFRFMP-ASVSLMWVIVGVLVLLFLYF-QLSFFNWREPPGPRPLP----LLGNLFQVDLKRLDQSLFDLSKKYGPVFVVNFGPKKVVVLAGYRTVKQALVNQAKEF-------GNREVTPIFY-DFNKEHGILFANGE----SWNEMRRFALSTLR-------DFGMG------KRISEQNIIEECRWLIEELEKLQ------GKPFDNTHTISYAVSNVLSGLMFGKRFDYQDPLLQAIVDRDNEIIYLTGTVSILLYNMFP-------WLGPWLKN-WKTLMKNMEAAKTDM---KKIIAELKDTLDPDTRRCFVDAFLTQKQNLK--EVNGSHYHDDNLLYTVMNLFAAGTDTTATTIEWCLLFMAKYPHIQERVQEELNWVVGSRQVRIEDRK--------------------------------NLPFTDAVIHESQRLANIAPMAIPHTTSKDV----TFQGYFIKK-------GTTVLPLLTSVLYD----ESEWESPRTFNPSHFLDKEGKFLKRGAFMPFSAGRRVCLGESLARMDIFLFFTS---------------LLQHFSFTPPPGVSEDELDLTP-----------------------VVG--FTLSPQPQGLCAVRRQ---------------------------------------------------------------------------------------------------------------------------------------------- Oryzias_latipes_CYP2K29 -----MQILD-FFQSYSSVSLVGILAVLVLYFISQ-FIFNSEQHGQEPPGPRPLP----IIGNLMQIDLKRPYKTLEEFSKTYGPVFTVFFGGEKVVVLAGYKTVKNALVNHDEEF-------GERAIPPIIQ-ELNKGLGVLWSNGD----IWRDIRRFALTNLR-------DFGMG------KKACEDKITEECQYLLEVFKKFK------GNAFDTTKPLNYAVSNIICSMVYGSRFEYDDPKFTSMVDRTNRNIQLSGSPTLQAYNMVP-------WLFKWVAS-RREVHECAAANRKQN---QSIFSHLKETLNPQMCRGFVDAFLVKGQTLEKSGVTNSAFNDENLLMTVIHLFAAGTETTSTTLRWGLLLMAKYPKIQDQVQDELRRVIGDRMVQVSDRK--------------------------------NLPFTDAVIHEIQRLASIVPTALPHKTSKDV----TFQGYFIKK-------GTTVFPLLTSVLHD----ANEWEKPHTFYPAHFLDKDGKFVKREAFIPFSAGRRICLGESLARMELFMFFTT---------------LLQNFCFTPPPGVSKEELSLTP-----------------------CGG--ITVGPVPHKLCAVPCSE--------------------------------------------------------------------------------------------------------------------------------------------- Oryzias_latipes_CYP2K30 -----MGVWDTLLPSLSPSSLLGAGVLLLLVFLFCPHRTSSQKHRKEPPGPTPIP----ILGNLHQLDLKRPDQTFMKFAKKYGSVFTVYMGPKKTVVLTGYKTMKEALVNYAEEF-------GEREAPTVAK-EAHLDCGVVWANGA----SWREMRRFALSTLR-------DFGMG------KRACEDKIIPECHSLLKEIRKFQ------GEAFDPTLIINSAVCNVICSMVYGTRFEYDDPDFRTILSRTMKGIQLLGSPGVQLHNLFP-------RIGRLFLSASKQINQIFTANKNYH---LKLL---KETFTPHTCKSIADAFQLR--QQEEDGFPNSHFHDANILVTIMNLFTAGTETTAATLRWALLFMAKYPKIQDQVQEELSRVMEGRQVTVEDRQ--------------------------------RLPFTDAVIHETQRKANIIPLSLLHRTSQDV----TFKGFFIEK-------GTTVIPVLTSVLYD----ENEWEKPNIFYPAHFLSKDGKFLKRDAFMPFSAGRRLCLGESLARMELFLFFST---------------LLQHFRIAPPLGVSEEELDLTP-----------------------RPG--GTLSPQPHKLCLVSLK---------------------------------------------------------------------------------------------------------------------------------------------- 'Takifugu rubripes CYP2K-like1' -----MSLQDFLLSLG--PSTLMGSVALLLLLCLVSR-SFGRATRREPPGPRALP----LLGNLLQLDLSRPHQTLYQLSKKYGPVFKVHFGPRKVVVLAGHKTVKEALVGNAEQF-------GDRDISPIFY-DMNQGHGILFSNGE----TWKEMRRFALSTLR-------DFGMG------KRMIEDKIAEECNYLIQKFEDHE------GRAFDTSRLANYATSNIISSIVYGSRFDYDDPRFINMVNRANEVIRLTGSAPIQLYNIFP-------GLANWIKN-RQLLLKQVAMNFRDM---TDLIQQLKDTLNPGVCRGFVDCFLLRKQKAVDSGVIDSLYNEKNLLYSLSNLFGAGTDTTATTLRWGLLLMAKYPRIQDQVQQELSMVVGNRRVCVEDRK--------------------------------NLPYVDAVIHEIQRLGNIAPMAVPHKTARDV----EFRGYFIEKVKYF-SEGTTVFPLLTSVLYD----ENEWETPHTFNPSHFLDKDGKFIKRDAFMPFSAGRRLCLGEGLAKMEIFLFFTS---------------LLQQFRFTPPPGVGEDELDLTP-----------------------ALG--FTLSPSPHKLCAIPRQ---------------------------------------------------------------------------------------------------------------------------------------------- 'Takifugu rubripes CYP2K-like2' ------MIEDLFESS--TSGFLMVAIVSLLLLQLCFS-FISREKRKDLPGPEALP----LLGNLHQLDLKRLDCHLVQLSQKYGPIFRVYLASKKVVVLAGYTAVKQALVNQAEDF-------GEREIFPIFH-DFNKGNGILFTNGD----QWKEMRRFALMTLK-------DFGMG------KKIEEK-IIKECQYLIEAFEQHQ------GEAFSNAQVISYATSNIISAIMYGRRFDYKDPTFQAMIERDHEVIHLTGSPSIQIYNIFP-------WLGPFLKT-WRYIMKKVEINIEST---RRIIGEMKETRNPGTCRCFVDAFLIHKENQEESDVNAHYYHEDNLLHCAMNLFGAGTDTTATTLQWGLLYITKYPHIQDGVQEELRRVVGNRQVRVEDRK--------------------------------NLPYMEAVIHETQRMANIVPMSLPHRTSRDR----HLLGSICPQ-------GTMVIPLLTSVLYD----ESQWEKPHTFNPAHFLDDEGRFVRRDAFMPFSAGRRMCLGEGLARMELFLFFAS---------------LLQHFRFKPAPGVSEDSLDLTP-----------------------VVG--ITLNPLTHKLRAISRF---------------------------------------------------------------------------------------------------------------------------------------------- Takifugu_rubripes_CYP2K1 -----MGIVDLFLQASSSVSLLGALALLLFVYFISSVSFSSKKDRKCPPGPKPLP----ILGNLLQFDLKRPYNTLMKLSKTYGSVFTVYLGPKKVVVLAGYKTVKEALIDHAEEF-------GERDPIMLVQ-NANHEHGVLWSNGE----SWKEMRRFALTNLR-------DFGMG------KKACENKIIEECSYLMEELKKWK------GEPFDTTHPINYAVSNIICSMVYGNRFEYDDPEFTSLVDRTNTLIQISGSPSVLVYDLFP-------WIG-PLVNNKKLFQSLFAANKKQN---LQLFAAAKEMLNPQMCRSFVDSFLARQQILEKSGT-NVHFHDENLMSTVMNLFNAGTDTTATTLRWGLLLMAKYPLIQDQVQEELRRVIGSRQVQVEDRK--------------------------------SLPFTDAVIHETQRLANIVPMALPHKTSQDV----TLQGFFIEK-------GTTVYPLLTSVLYD----ETEWEKPLNFYPAHFLDKDGKFVKREAFLPFSAGRRICLGEGLAKMELFIFFST---------------LLQHFRFRPPPGVSEDHLDLTP-----------------------RVG--LTLNPSAHKLCAVSCL---------------------------------------------------------------------------------------------------------------------------------------------- ; END;