#NEXUS BEGIN TAXA; TITLE Taxa; DIMENSIONS NTAX=76; TAXLABELS Amphimedon_queenslandica_GI_340369066 Amphimedon_queenslandica_GI_340369314 Amphimedon_queenslandica_GI_340371337 Amphimedon_queenslandica_GI_340373367 Amphimedon_queenslandica_GI_340377126 Amphimedon_queenslandica_GI_340379293 Amphimedon_queenslandica_GI_340380476 Amphimedon_queenslandica_GI_340381019 Amphimedon_queenslandica_GI_340381980 Amphimedon_queenslandica_GI_340383363 Amphimedon_queenslandica_GI_340384408 Homo_sapiens_CDK1 Homo_sapiens_CDK10 Homo_sapiens_CDK11B Homo_sapiens_CDK12 Homo_sapiens_CDK13 Homo_sapiens_CDK14 Homo_sapiens_CDK15 Homo_sapiens_CDK16 Homo_sapiens_CDK17 Homo_sapiens_CDK18 Homo_sapiens_CDK19 Homo_sapiens_CDK2 Homo_sapiens_CDK20 Homo_sapiens_CDK3 Homo_sapiens_CDK4 Homo_sapiens_CDK5 Homo_sapiens_CDK6 Homo_sapiens_CDK7 Homo_sapiens_CDK8 Homo_sapiens_CDK9 Homo_sapiens_CDKL1 Homo_sapiens_GSK3alpha Homo_sapiens_MAK Monosiga_brevicollis_GI_167516186 Monosiga_brevicollis_GI_167516210 Monosiga_brevicollis_GI_167516962 Monosiga_brevicollis_GI_167517533 Monosiga_brevicollis_GI_167522415 Monosiga_brevicollis_GI_167522771 Monosiga_brevicollis_GI_167525607 Monosiga_brevicollis_GI_167525918 Monosiga_brevicollis_GI_167536606 Monosiga_brevicollis_GI_167538010 Nematostella_vectensis_GI_156349526 Nematostella_vectensis_GI_156360882 Nematostella_vectensis_GI_156365870 Nematostella_vectensis_GI_156374066 Nematostella_vectensis_GI_156383566 Nematostella_vectensis_GI_156385093 Nematostella_vectensis_GI_156391793 Nematostella_vectensis_GI_156392090 Nematostella_vectensis_GI_156398520 Nematostella_vectensis_GI_156403969 Nematostella_vectensis_GI_156407302 Nematostella_vectensis_GI_156408568 Salpingoeca_rosetta_GI_326426444 Salpingoeca_rosetta_GI_326430756 Salpingoeca_rosetta_GI_326431660 Salpingoeca_rosetta_GI_326434528 Salpingoeca_rosetta_GI_326436991 Salpingoeca_rosetta_GI_326436992 Thecamonas_adhaerens_GI_195996637 Thecamonas_adhaerens_GI_195996663 Thecamonas_adhaerens_GI_195998898 Thecamonas_adhaerens_GI_195999760 Thecamonas_adhaerens_GI_196000717 Thecamonas_adhaerens_GI_196001193 Thecamonas_adhaerens_GI_196001971 Thecamonas_adhaerens_GI_196002669 Thecamonas_adhaerens_GI_196003954 Thecamonas_adhaerens_GI_196010283 Thecamonas_adhaerens_GI_196013334 Thecamonas_adhaerens_GI_196013348 Thecamonas_adhaerens_GI_196015356 Thecamonas_adhaerens_GI_196015366 ; END; BEGIN CHARACTERS; TITLE Alignment_of_metazoan_CDK; DIMENSIONS NCHAR=283; FORMAT DATATYPE = Protein GAP = - MISSING = ?; MATRIX Amphimedon_queenslandica_GI_340369066 YEKLEKLGEGTYATVYKGKSNITGKLVALKEIRLEH-EEGAPCTAIREVSLLKDLKHANIVFLHDIIHTARSLTLIFEYVEQDLKQYLDQCSGMMAMPNVKLFLFQLMRGLQYCHSRKILHRDLKPQNLLISEQGDLKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSIDYADSIDMWGVGCIFYEMIVGRPMFPGANVEEELVLIWKSLGTPNEKTWPGITKNKEFISHSFLRYDPQPLGLIVPRLDKEGINLMSKLLSYESQERLLARDGMKHNYF Amphimedon_queenslandica_GI_340369314 FEILSQIGEGTFGKVYKAKDLKTGEVIALKKVLIDSEREGFPITAVREIKILRQLRHENIVTLKEIISDSSSFYLVFEYCAHDLMGLIDSGMVVFSESHIQSLMRQLMEALCYCHSKNFLHRDLKCSNILINNKGQLKLGDWGLARYYFAHSRLYTNHVITLWYRPPELLLGAEHYGPAVDIWSCGCILGELFTKKPLFHGSIEMEQLDAISRVCGTPTPANWPEVIKLPLFQTFKFKKLYRRRVKEEYSNIPEVPLDLLDKLISIDPSKRISSEEALNHPFL Amphimedon_queenslandica_GI_340371337 FNKLNRIGEGTYGVVYRAEDKKSKEIVALKRIRMENEEEGLPICSVREIGLLLSLSHENIVQLKEIAVGLDNMFLVMNYCEQDLASLIDNMASPFTEPQVKCIMLQLLEGLSYLHNNHVIHRDLKVSNLLLTDKGILKIADFGLARTLGRPLKPLTPTVVTLWYRAPELLFGSREYSCSLDMWSVGCIFGELLLNKPLLPGKSEANQIELITNLIGSPNEGIWPGYSKLPLVASLEIKRQPYNNLKEKVYWISETGRGLLNDLLTYNPEYRMSSSRALRCKYF Amphimedon_queenslandica_GI_340373367 YRKLDILGEGQFATVYRAEDTERNAIVAVKKIKIGQARDGINRTALREIKLLQELHHPHILGLLDVLGHKSNISLIFDFMDTDLEMIIKDKSLLLPPGVVKAYSLMILQGLEYLHAHWILHRDLKPNNLLINKDGVLKITDFGLAKAYGSPNRIMTHQVVTRWYRSPELLFGARLYSTGVDLWAVGCIIAEMLLRLPFLPGETDLGQLSTIFEFFGSPNEENWPSVKSLPDYVE--FKPSPPQSFRDVFSAAGDDLIHLLESCMKLDPSKRCTASQALQSSYF Amphimedon_queenslandica_GI_340377126 YEKLTKVGQGTFGEVFKAKDRKTGRLVALKKVCMENEKEGFPMTALREIRILQLLQHNNIVNLVEICRSKGSIYLVLDFCEHDLAGLLECKEIKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKANQRYTNRVVTLWYRPPELFLGERNYGPPIDMWGAGCIMAEMWTRRPIMQGDTEQKQITLICQLCGSISPTEWAGVEKLEYYQKLELPQKENRKLKERLRHEDPYALDLIDKLLMLDPRKRIDADSTLEHDFF Amphimedon_queenslandica_GI_340379293 YERLEKIGEGTYGVVYKARQATHGRVVALKKIRLDAECEGVPSTAIREISILKELDHVNIVSLLDVLYCDRKLFMVFEFLDYDLKKYMDRHAP---TGIPTDYLYQLLEGVAYCHAHRVLHRDLKPQNLLISSDGRIKLADFGLARAFGVPVRTYTHEVVTLWYRSPELLLGSQYYSTPVDIWSIGCIFAEMVTKRPLFPGDSEIDQLFRIFRTLGTPDESVWPGISSFPDYKSS-FPKWPRQNLQRIVKSLDTLGINLLEQMLCYEPCKRITAINGMRHPFF Amphimedon_queenslandica_GI_340380476 FEYEKKIGRGTYGHVYKAKKRSGDKEYALKQI----EGTGISMSACREIALLRELKHSNVISLQRVFLSDRKVWLLFDYAEHDLWHIIKYHQVQVPKTMVKSLMYQILSGIHYLHSNWVLHRDLKPANILVMERGRVKIADMGFARLFNAPLKPLDPVVVTFWYRAPELLLGAKHYTKAIDIWAIGCIFAELLTFEPIFHCRQEREQLERIFLVMGFPHDRDWDDMKHMPEYSTLMFGRQANCALQKYMVKHDTSAFKLLTKFLVMDPNKRITSDQAMLDTYF Amphimedon_queenslandica_GI_340381019 YTKLEKIGEGTYGVVYKARHKVTGKTVALKKIRLENEEEGVPSTAIREISILKEVQHTNVVKLEDIIHQDLKLYLVFEFMCMDLKKYLDSLPAFMEPDLVKSYTYQILKGIVFCHGRRIIHRDLKPQNLLIDNNGGIKIADFGLGRAFGIPVRAYTHEVVTLWYRAPEVLLGCPRYSCPLDIWSIGCIFAEMSNKKPFFQGDSEIDQLFRIFRILGTPSDAIWPSVTTMPNFKST-FPKWTGKSLSQLCPHLDSIGCDLLMQMVIYNPGKRISAKRAMEHPYF Amphimedon_queenslandica_GI_340381980 YKILGRIGEGAHGVVLKARHTQTGDLVALKRVHLKKPADGIPNSALREIKALQESGNHHVICLRDMFPHGPGFVLVFDYMLSDLAEVIRNAEKPLTEAQVKSYMTMLLKGVAYLHDNKIMHRDLKPANLLISQTGHLKIADFGLARVLSTEGRLYSHQVATRWYRAPELLYGARQYDTGIDMWAVGCIFGELLNTSPLFPGENDIDQLCCVLRILGTPSERIWPGMSQLPDYHKISFSEMSPTPMEVVVPDALPEAVDLLKSFLVYDSRHRLSAAKALLHSYF Amphimedon_queenslandica_GI_340383363 YEWLNRIEEGTYGVVFRARDIRTDEIVALKKLKMEKEREGFPITSLREISTLLKANHENIVNVREIVVGMDKIFIVMDYVEHDLKSLMETMKQPFLEGEVKTLLIQLLKAVHHLHDNWIIHRDLKTSNLLLSHKGILKVADFGLAREYGSPLKNYTPIVVTLWYRAPELLLGAKEYSTAIDVWSVGCIFAELLQHKPLFMGKSEIDELNLIFKELGVPNESIWPGFGELPVAKKVQFTQQPLNNLRKRFPMITKNGFVLLNKFFAYDPKRRVTAEDALKHEYF Amphimedon_queenslandica_GI_340384408 YERLEKIGEGTYGTVFKAKEKESGEIVALKIVRLDEDDEGVPSAALREICLLKELKHKNIVRLTDVLHKNLKLTMVFEYIDQDLKKYFDVSGGIISPQVVQSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGDLKLADFGLARAFGIPVRLFSAEVVTLWYRPPDVLMGAQVYNTSIDMWSAGTIFAELANGRPLFPGSDVDEQLKRIFKLVGTPTERSWPGLTKLPEFKEF--PPYPPACIESVVPALNDAGVDLLQRHLICHPTERISAEEAMRHEYF Homo_sapiens_CDK1 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT-FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF Homo_sapiens_CDK10 FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYF Homo_sapiens_CDK11B FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGLLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF Homo_sapiens_CDK12 FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL Homo_sapiens_CDK13 FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFL Homo_sapiens_CDK14 YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQE-EEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLVNHAEDLASKLLQCSPKNRLSAQAALSHEYF Homo_sapiens_CDK15 YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNA-EEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNIEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLVPEAEDLASQMLKGFPRDRVSAQEALVHDYF Homo_sapiens_CDK16 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEH-EEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF Homo_sapiens_CDK17 YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEH-EEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYF Homo_sapiens_CDK18 YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEH-EEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF Homo_sapiens_CDK19 FEYECKVGRGTYGHVYKARRKDGKKEYALKQI----EGTGISMSACREIALLRELKHPNVIALQKVFLSDRKVWLLFDYAEHDLWHIIKFHPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMERGRVKIADMGFARLFNSPLKPLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQFRRTANSSLIKYMVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYF Homo_sapiens_CDK2 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS-FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF Homo_sapiens_CDK20 YCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMENQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF Homo_sapiens_CDK3 FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGS-FPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF Homo_sapiens_CDK4 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGLPISTVREVALLRRLEHPNVVRLMDVCATEIKVTLVFEHVDQDLRTYLDKAPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ-MALTPVVVTLWYRAPEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGA---FPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL Homo_sapiens_CDK5 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY--PMYATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF Homo_sapiens_CDK6 YECVAEIGEGAYGKVFKARDLKGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLEHPNVVRLFDVCTVETKLTLVFEHVDQDLTTYLDKVPEGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ-MALTSVVVTLWYRAPEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQA---FHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF Homo_sapiens_CDK7 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT--FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF Homo_sapiens_CDK8 FEYECKVGRGTYGHVYKAKRKDGKKDYALKQI----EGTGISMSACREIALLRELKHPNVISLQKVFLSDRKVWLLFDYAEHDLWHIIKFHPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMERGRVKIADMGFARLFNSPLKPLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMFRRNTNCSLIKYMVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF Homo_sapiens_CDK9 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKARDPYALDLIDKLLVLDPAQRIDSDDALNHDFF Homo_sapiens_CDKL1 YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYF Homo_sapiens_GSK3alpha YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDK------RFKNRELQIMRKLDHCNIVRLRYFFYSKLYLNLVLEYVPETVYRVARKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPTAVLKLCDFGSAKQLVR-GEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN--PNYTEFKFPQIKAHPWTKVFKRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF Homo_sapiens_MAK YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKF-YSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-PPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYF Monosiga_brevicollis_GI_167516186 FDLVNEVGQGTYGQVSKARIKNTDQLVALKMLKMEADRDGFPVTALREIKILRQLRHESIINLIGIVADPAAFYLVFEYMEHDLYGLLSSKQCTLDQEQIRYLMFQLMDGLRYCHAKHFIHRDIKGANLLVDNQCRLKIADFGLARLYEDRSRAYTNNVITLWYRPPELLYGAEVYGPEVDVWSAGCILGEFFLCRPMFRAGTEIEQLHAISMACGTPDPTNWPEAQNLPAFKTLRPRKRYERNLAGFFRALYVRRLGLLSPLMGYSPTSR------------ Monosiga_brevicollis_GI_167516210 FRILGRIGEGAHGVVFKAKHIESGVVVALKRVGLKRIEAGIPVALLREIQALRHVQHPNVVRLHDAFAH------------------------------------------AACVLRGIIHRDLKPSNLLISPQGQLKIADFGLARIWHQDGRQYSHQVATRWYRAPELLFGARHYDLGVDLWAVGCIFAEMINSAPLFPGENDIDQLSCVLHTLGTPTPENWPEASTFPDYGKITFDETPGVPPEDLVRNTSPEGRTLFASFVPYSAKRRQSARSALRSLYF Monosiga_brevicollis_GI_167516962 FEKLNILGEGTYGVVYRARDSRTGHQVAVKQVKMNQERGGLPLSSLREITALQQLRHTNVLQLLHVAAGLTSIFLIMEYCEHDLAALVDNMPAPFPEPAVKCLMQQLFAGLDAMHRECLIHRDLKLSNLLLTDHGILKVADFGLTRVIEDPAHHMSPTVVTLWYRPPELVFGMKNYTRAVDIWSCGCIFAELLAHEPLFPAKTEVALLEMVIGLLGAPHESIWPAFRDLPLAHRFHMPHQPYSNLKQRFGFLSSTGLDLMQDLLMYDPEKRLSAIAASVHPYF Monosiga_brevicollis_GI_167517533 YLKIEKIGEGTYGTVYKAKVKATGNLVALKKIKLEAEEEGVPSTAIREISLLKELSHPNVVSLMEVIHSENKLYLVFEFLDQDLKKHIDSQRNGLSMELIKSYMLQLLKGIDFCHARRILHRDLKPQNLLINREGFIKLADFGLARAFGIPIRAYTHEVVTLWYRAPEILLGQRQYACPVDMWSIGCIFAEMVTRRPLFPGDSEIDELFRIFRVLGTPTEQTWPGVSQLPDYKDC-FPRWSGEGLASLIPGLDAMGLDLLQKMLRYEPSQRISARQALTHPWF Monosiga_brevicollis_GI_167522415 YKKLHKLGEGTYATVFKGISHINGKIVALKEIRLEH-EEGAPCTGIREVSLLKGLKHANIVTLHDVIHTKDNLIMVFEFLSKDLKAYMDDCNSYIDLRNAKLFLFQLLRGVGFCHSRKVLHRDLKPQNLLINHAGELKLADFGLARAKSVPIKTYSNEVVTLWYRPPDVLLGSVDYSGDIDMWGVGCIFGEMISGRPMFPGATNADQLELIFKTLGSPSESTWPGVMALPEAKSNELGAYSPQPVNAILPRLDKQGGALLKSLLKLDPHGRVSAVKAMQHPYF Monosiga_brevicollis_GI_167522771 YAKIDKLGEGTYGVVFKARDRHDGSIVALKRISLESAAEGVPSNAVREISLLKSLHHPNIVRLYDVLHSEHKLTMVFEYCDQDLKKFLDSCRGTPEHHVIQSFMFQLLQGIRHCHEERVLHRDLKPQNLLINKRGQLKLADFGLARPYGVPVRSYSHEVVTLWYRAPDVLLGATGYDTSIDMWSAGCILAEMANGSPLFPGTSVQDQLDLIFRVLGTPTIESWPGLHELPNYSGPFLPHVDGVGLEAEVSSLFPEGLDLLQQLLRYVPDERLSADRALRHRFF Monosiga_brevicollis_GI_167525607 FSPVGTGGEGTYGEVKRCRHVATQQIVALKKIKTEQEANGFPQTALREIQILKQLRHENIVQLQSVAVVGKFCYMVLEFVDHDLNRILTAIKSPVSTTIFKGLALQMLRGLDHLEKNCVLHRDLKPANILLSAQGVIKLADFGLAKYHHPDRKGHTALVCSQWYRPPELLAGQVSYPEKIDSWSLAVVMGELFNLDPLFDGRTSTYQFIQIQKLCGTDSFAWLEDCPLLPAKGH--KKRQVSQRFNTLIARSSEAVVAFMDKALTVDPNHRLLAGELLKWEHK Monosiga_brevicollis_GI_167525918 FANAGCVGQGTYGIVHKVYRLEGRKPYALKGMVTVSRTEGFSTANLRELALLRELHHDNVISLREAFIHTKEVWLLFDYAEYDLWWLCNDHNLRLQEPMLKSIMFQLLQGVHYLHEQWVLHRDLKPANVFLTRGGSIKIGDLGMARVFVAPPKAFDPVVVTYWYRAPEIMLGAKHYTKAIDIWSIGCIFAELINLVPIFHVKNDAAQLEAIFKVLGMPDEQKWSLLKHMPRYPDLKFKTK-----DDVLEPESSTRLSLMRRMFHYDPEKRISADEALTAPWF Monosiga_brevicollis_GI_167536606 YEKVKYLGEGQFGTVYLERDSQTGQLYAIKRIRLGDAKEGLNQSAFREIMFLREVHHPNIIDLHDVFLKKGNLHLVLELASTDLEKLIRNKRLDFAPGDVKSLLLQTYQALDYLHARWILHRDLKPNNILITTGGQVKLTDFGLACTFGSPSREMTTQVVTIFYRAPELLLGARHYGVGVDIWAMACIHMELELRTPILPGDGPFDQLDKIMAFLSSFGHAAQPNYRELSSSWE--FKPRDPTPIRALLPAVSDAAIDLLEKQFTYDPLKRPTARETLMHPYF Monosiga_brevicollis_GI_167538010 YEHLNRIDEGTYGVVFRVRDRSSGHIRAVKRLKMEKEKSGFPVTSLREINTMLKVRHENIVRVEEIVVGMDDIFIVMEFVEHDVKALLESIQKPLLQAEVKTLMLQLLSGVAHLHDNWILHRDLKTSNLLLSHRGILKIADFGLAREYGDPLKEYTTLVVTLWYRAPELLLGAKSYSTAIDMWSVGCIFSELLTRKPLFDGNGEIDTMNKMFKMLGVPDETRWPGLNDLPVPRSMSLRGPSENRLPRSYGILPSSGVNLLSDLLCYDPAQPYLEQQ--KQSRF Nematostella_vectensis_GI_156349526 FEKLNRIGEGTYGIVYRAKDTKSGKIVALKKVRMEQERDGIPISGLREITLLLNLRHENIVQLLEVVVGLDSLFLSMEYCEQDIASLLDNMSCPFSEAQIKCLMIQLLEGTKYLHEHFIVHRDLKVSNLLLTGKGVLKIADFGLARTFGYPYKPMTPVVVTLWYRSPELLLGAKVHTTAVDMWAVGCIFGELLGNKPLLAGKSEINQLQLIVDLLGTPNDHIWPGYSSLPGVKSISLKHQPYNNLKHKFSWVSQAGLSLLNYMLMYDPCKRATAAESLQSSYF Nematostella_vectensis_GI_156360882 YKKIDFLGEGQFATVFKAEDQETGNIVAVKKIKLGNAKDGINRTALREIKLLQELSHENVIGLLDVFGHKSSISLVFPFMETDLEVLIKDTCIVLSPADVKSFTIMTLKGLEYLHSHWILHRDMKPNNLLLDDKGVLKIGDFGLARAFGSPSRVYTHQVVTRWYRPPELLFGARIYGTGVDMWAEGCILAELLLRVPFLPGATDLDQLSRTFQTLGTPTEETWPGMTSLPDYVE--FKPFPGIPLKDIFSAAGDDMLDLLDRLLDCNPNGRVNATQALNMPYF Nematostella_vectensis_GI_156365870 YERQAKIGQGTFGEVFKAKNRKNKEIVALKKVLMDNEKEGFPITALREIKILQLLNHENVVKLLEICRTKASIYLVFEFCEHDLAGLLNNQAVKFSPPEMKKIMQMLLNALYFIHSNKILHRDMKAANILITKNGVLKLAEFGLARAIHIQKQRYTNRVVTLWYRPPELLLGERNYGPPIDLWGAGCIMAELWTRTPIMQGNTEQHQLTLISHLCGSITPEVWPGVDKLELFDKMVLPSGQKRRVKERLRMKDHNALDLIDKMLSLDPGPRIDADSALNHDYF Nematostella_vectensis_GI_156374066 YEEVAEIGTGAYGTVYKAKDLLDGKFVALKRVRIQNSEEGMPLSTIREIALLKQIAHPNVVRLLDIFHIETHLNLVFEHVDQDLAAYLEYCPQGLGEWKIKDLTYQILNGVDFLHTHRIVHRDIKPQNILVTKDGQVKIADFGLARVYKDA-MALTSVVVTLWYRAPEVLLQS-SYATSVDIWSVACILAELFNRRPLFEGKNDVDQLDKIFSIIGSPSQDEWPQNVSLPWTS---FSRYTTGSFQALVPEMCTEGTTLLKEMLQFLPRSRPSASEAMNHPFF Nematostella_vectensis_GI_156383566 FQWLNRIEEGTYGVVYRAKEKASGEVVALKRLKMEKEKEGFPITSLREINTLLKAQHPNIVHVREIVVGMDRIYIVMDYVEHDLKTLMEHMTSPFTVGEVKTLLIQLLRATAHLHDNWILHRDLKTSNLLLNNRGILKVGDFGLAREYGSPLRHYTPIVVTLWYRAPELLLGIKEYSCPIDMWSVGCIFAELLTMEPLFPGRSEIDQINRIFKELGTPSDKIWPGPSELPHVKKMTFTEYPYNQLRNRFGYLTDKGFSLLNRFLTYDPKKRITAETALKEDYF Nematostella_vectensis_GI_156385093 FEKVEKIGEGTYGVVYKARDKTTGRMVALKKIRLDTESEGVPSTAIREISLLKELNHPNVVSLLDVVHNQKSLYLVFEFLSQDLKKYMDCLPPGISTSLIKSYVYQLLSGVAYCHSHRVLHRDLKPQNLLIDKNGAIKLADFGLARAFGVPVRSYTHEVVTLWYRAPEILLGSRYYATPVDVWSIGCIFAEMKTRRALFPGDSEIDQLFRIFRTLGTPDDKVWPGVSELPDYKTS-FPKWPVQSIRHVLPTLDNTAIDLLQKMLTYQPNARISAKAALSHEFF Nematostella_vectensis_GI_156391793 FSKIEKIGEGTYGVVYKAKNLKTGGFAALKKIRLEVEDEGIPSTAVREISLLKELRHPNVVELQHILHQEPKLYLVFEYLTCDLKKHLDTTRGMLDKTLVKSYLYQITNAIYFCHARRILHRDLKPQNLLIDSKGLIKLADFGLGRAFGIPVRAYTHEVVTLWYRAPEVLLGGQRYSCPIDVWSIGTIFAEMVTKRPLFHGDSEIDQLFRIFRILGTPTEETWKGVTSLPDYKPT-FPKWAGDGLKKAVPQLDSDGLDLLKKMLIYDPALRISAKTSLKHPYF Nematostella_vectensis_GI_156392090 YQKLEPLGEGSYATVFKGLCTANKKIVALKQIRLQE-EEGAPFTAIREASLLKQLKHGNIVKLHDIIHTKDTLMFVFEFLDTDLNCYLEKYSRGICPHNTQLFCFQLLRGLAYIHDRKILHRDIKPQNLLISERGELKLADFGLARAKSVPSQTYSHEVVTLWYRPPDVLLGSKNYTTSLDIWGAGCIFVEMLTGIALFPGLNHIDQLNKIWQVLGTPTDETWPGVSKLPEYDPDIFINFRPRRIGQCIPRLVEGAEQLVIRMIQLDPKNRISAREAMRSTYF Nematostella_vectensis_GI_156398520 FDIIEQIGEGTYGQVYKAKDKITGELVGLKKVRTDNEKEGFPITAVREIKILCQLNHPNIINLKEIVTDKGAFYLVFEYMDHDLMGLLESGLVHLTEDHIKSFIRQLLDGLNYCHKKNFLHRDIKCSNILLNNKGEIKLADFGLARLYEAERRPYTNKVITLWYRPPELLLGEERYGPGIDIWSVGCILAELFTKKPIFPAYQEIGQLELISRVCGTPTPAVWPSIINLPHFHSIKPKRQYRRRIREEFNFLPEDALDLFDAMLTLDPSQRITAEKALEHPFL Nematostella_vectensis_GI_156403969 YTKLDKLGEGTYATVFKGKSKLTDNIVALKEIRLEH-EEGAPCTAIREVSLLKGLKHANIVTLHDTVHTQKSLTLVFEYLEKDLKQYMDDCGGIMSMNNVRIFLFQLLRGLDYCHKRKVLHRDLKPQNLLINDKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTAYSTQIDMWGVGCIFFEMATGRPLFPGSTVEDELLLIFKVLGTPSEEVWPGISANEAFIAGKFPDYPRENLIIHAPRLDNSGLELLEKFLEYTVKDRVSAHDAMRHDYF Nematostella_vectensis_GI_156407302 YDKLEKIGEGTYGTVFKGKNKETREILALKRVRLDDDDEGVPSSALREICLLKELKHNNIVRLYDVLHSEKKLTLVFEFCDQDLKKYFDSCQGEVDASVVKSFMFQLLRGLAFCHSHNVLHRDLKPQNLLINKDGELKLADFGLARAFGIPVRCFSAEVVTLWYRPPDVLMGAKLYSTSIDMWSAGCIFAEMANGRPLFPGNDVDDQLRRIFKILGTPTEESWPNVSKLPDYKEF--PPQPSVSLGMVVPKLSSTGRDLLQKLLVSNPAHRISAEDAMKHAYF Nematostella_vectensis_GI_156408568 YTILGRIGEGAHGIVFKAKHIESGEIVALKKVPLRRLEDGIPNTALREIKSLQENENPYVVKLIDVFPHGTGFVLVFEYMWSDLSEVLRNSERPLTEAQIKGYLLMLLKGVAYCHNKGIMHRDLKPANLLISSTGHLKIADFGLARVFSNEERQYSHQVATRWYRAPELLYGARKYDEGVDLWAVGCIFGELLNNSPLFPGENDIEQLCCVLKTLGTPNEEIWPGMTDLPDYNKITFPDMPAIPLEKIVPDASPEAMDLLKRFLVYPSKKRIPASEALLHPYF Salpingoeca_rosetta_GI_326426444 YVRICKVGEGTYGQVYKAQDRQNSQIVAIKAITLNGGAEGVPSNAVREISLLKRLDHPNIVRLLDVLYSQTRLMMVFEFCDQDLKQFLSHKPIQHDPNLAQTIMFQLLRAVAYIHSQHILHRDLKPQNILLDRKGRLKLADFGLARPIGVPVSKYTADVVTLWYRAPDVLLGSEHYGPCIDLWSTGVIFAEVLTGQPPFQGNSINEQLLLIFDMLGTPPP-SWD-MRQYERYKDFSMRHATSVGLETFLSRAAPVAVDLVKALLRYNPDARITAEAAMEHEFF Salpingoeca_rosetta_GI_326430756 YRIERRVGEGAHGVVFLGVHLASGQRVALKKVTLARLDDGIPTQVIREIRALCQLTHKNVVTLHDVFPSGMGIMLCFEYMASDLARVLQGQNLPLSAPHVKRYMSMLLSGVDFCHSHAIVHRDLKPANLLISATGQLKIADFGLARVYDE-ARPMSHQVATRWYRAPELLYGARVYDFGVDIWAVGCIFGELLNNSPLFPGENDIDQLSCVIQALGTPTRQDWPELDSLPDFAKINFDPTDPQPMHEILPDATQDAINLCSQFLVYSSSRRLPAAKALVHPYF Salpingoeca_rosetta_GI_326431660 FERLGRLGEGTYGIVYKAKDIETGAIVAVKRIKMKDEREGMPQTSLREVTTLKAMEHENVVQLLDIAVGHDQVYLIFEYCEHDLAWLVDNLPAPFPETVAKSLTVQLLKGLRALHSMFIVHRDIKLSNLLLNSRGYLKIADFGLARRSGDPPRPKTTNVVTLWYRAPELLFGDKAYTSKVDCWSAGCVMGELLAHKPILPGKSEVSQLDLIIQLLGTPNEAIWPGFSSLPLASRFQLTAQPYSNLKDEFRFISDRGIDLLQRLLTYDPHQRWSCDRALGHAYF Salpingoeca_rosetta_GI_326434528 YKKIAVLGEGQFGTVFLAEHTDTKERFAVKKIKVGSAEEGLHRTAFREIKFLQELRHANIIQLRDIFAKGFNIHLVLELCKCDMRAIILEN-IQLTPSDIKSLMLQCLQGLEYLHSHWIIHRDLKPENIFITRKGIVKLADFGLASTFGSPSRAYTAQVVTIYYRAPELLFNSKAYGAGVDVWAMGCVHGELELRRPLLPGTSEIDQLSRIFALRGSVNEHNWPGVTKLPGFLEVRFDQQNPTPLRHVMPAASDLALSLMDGLLTCDPAKRLTIKQALKHAYF Salpingoeca_rosetta_GI_326436991 FEKTEKLGEGTYGSVYKAIDKTTMAVVALKKIKLNDQEFGVPASALREIALLRELDHPNIVQLLDVIPSSSELHLILEYVYEDLRKFMHRVK-VLERPMYQSFLRQLLLGLEYCHIHRILHRDLKPENLLINHTGALKLADFGLARAFGIPVRAYTHEVVTLWYRAPEILLGSKQYACPVDMWAVGCIFAEMASSKPLFPGDSEVDQIMRIFRYLGTPTEKTWPGVSNLPDFRAN-FPRFPAIDLAPIVPQMDPVSMALLQHMLVYLPASRIPANQALKHPFF Salpingoeca_rosetta_GI_326436992 YEKIEKIGEGTYGTVYKAKLITSGELVALKKIKLETEEEGVPSTAIREISLLKELNHRNVVRLIEVIHSEHDLHLVFEFLDCDLKKHMEVS-RQLAPDLVRSYLFQLLKGIEFCHTHRILHRDLKPQNLLIDSDGNIKIADFGLARAFGIPVRAYTHEVVTLWYRAPEILLGARQYACPVDIWSIGCIFAEMVTTRPLFPGDSEIDELFRIFRYLGTPNEHVWPGVSELPDFKTT-FPQWKRQDLAKLVPGLDPTGLDLLEQMLRYAPSARISATRALRHPYF Thecamonas_adhaerens_GI_195996637 YDKLHKLGEGTYATVFKGRSKLTNDFVALKEIRLEH-EEGAPCTAIREVSLLKDLKHANIVTLHDTIHTERSLVLVFEYLDRDLKQYMDSCGSILDMSNVKIFLFQLLRGLAYCHSRRVLHRDLKPQNLLINERGELKLADFGLARAKSVPSKTYSSEVVTLWYRPPDVLLGSTEYSTSIDMWGVGCIFYEMATGLPMFPGSSTENQLQTIWEILGTPTEEEWSGLTRNLKVNSLSFHDCKGEPLRNRAPRLEADGLDLLAKFLQYKAKSRISSADAMKHKYF Thecamonas_adhaerens_GI_195996663 FTILGRVGEGAHGVVFKAKHVGNGEVVALKKIHLKKIDDGIPNNILREIKTLQAITHENIVRLFDVFPDGSSLVLAFEYMVTDLSEILRSSQNTLPE-VSSYYMIMLLRGISFCHENHIIHRDLKPANLLISSSGQLKLADFGLARVMSVEERLYSHQVATRWYRAPELLYGSRTYDEGVDLWYLGCIFAELINKSPLFPGDSDIKQLGCVLSILGTPTTSTWPGLIELPDYNKITFSGFLPIPFESIVPDATSEVGKIK----------------------- Thecamonas_adhaerens_GI_195998898 YEKITKIGHGTFGEVFKARNRISKEFVALKRVLLGNEKEGFPITSLREIKILRALKHDNIVRLQEICRSRGSIYLVFEFCAHDLAGLLQNPQVKFNLSEIKRMMKHLLSGLFYIHSNKVLHRDLKAANVLVTRDGVLKLADFGLARVYSRKTHCFTNRVVTLWYRAPELLLGCRDYGPAIDMWAIGCIMAEFWTRSAIMQGNSETNQLTLITQLCGSITPEVYPDVDKLDLFKKFDLPASQKRRVKERLSHRDRHALDLIDRCLTIDPAKRIDSDSALNHDFF Thecamonas_adhaerens_GI_195999760 YVQVTEIANGAYGRVYKARDLNHNRLVALKKIAVINDEQGIPISTIREITSLKSLGHQNIVRLYDIFANTMDLTLVFEHVEQDLQTYIRNCPSGIDTRKIKDIIYQIVNAIDFLHANRIVHRDLKPQNVLISRQGIVKVADFGLAKVFCEN-VPITSVVVTLWYRCPEVLLQS-TYATPVDMWSVGCIMAELYLREPLFCGQTDIDQLQKIFSMTGLPDESEWPVNIPFSRST---FCQYTRRQYSEMMPEICQDGVDLLQKLLKFNPKERLTAEESLQHPYF Thecamonas_adhaerens_GI_196000717 YEKLVKIGEGTYGTVYKAVNHDTGEIVALKKVRIDDENEGIPSFALREICLLKELKHKNIVMLYDVIHGNKELMIVFEYCDQDLKRYCDACQGKIDPSIVQSFTNQLLQGLAYCHSHHILHRDITPQNILVTGNGDIKLADFGLARNFGIPVKSFSAEVVTLWYRSPDVLLGATLYDTSIDIWSTGCIFAELSNGQPLLPGKDVADQLKIIFKIFGTPNEQIWPGVSQLMKDKDY--PSYNAMSILHVVPNLNQLGCDLFQLMMVLDPSKRCTAEQALQHAYF Thecamonas_adhaerens_GI_196001193 YEKLEPLGEGSYATVYKGYSIGHQKLVALKEITLNE-EEGTPFTAIREASLLKQLKHANIVVLHDIIQTPTKLTFVFEYVTTDLSQYLNLHPGGLNMKNVKLFLYQLLRGLSYCHQRRILHRDIKPQNILVSEIGEIKLADFGLARAKSVPSKTYSPDVVTLWYRPPDVLLGSTNYSTSLDIWGVGCIFTEMVSGIATFPGVRNIDQLDKIWHKLGTPTEETWPGVTSYPEYCAAETMFYESRTIAEVIPRLDPGAADLATKMLQYQPFKRIFCQAAMNHQYF Thecamonas_adhaerens_GI_196001971 YKKIKLLGEGQFAVVYQAEDTHKNKIVAVKKIKLGPANDGINRTALREIKLLQELKHENIIGLLDVFGHKSNISLVFDYMEADLEVIIKDSSIILTNAHIKQYIIMTLRGLEYIHSNWILHRDMKPNNLLIDSNGILKLADFGLARYFGSPNRYYTNQVVTVWYRAPELLFGANSYGTGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFQTLGTPIEDKWADIHKLPGYIK--FKTLPAIPLNEIFTAASDDMLDLLRRLFEYNPSSRITATEALQMKYF Thecamonas_adhaerens_GI_196002669 --ILKQIGEGTYGQVFKAKIKDTDKLVALKKVRTDHEREGFPITAVREIKILKQLNHQSIVNLLGIVSNRCAFYLVFEYMDHDLMGLLESGLVTFDEEHIRSFMRQIMEGLNYCHKRQLLHRDIKCSNLLMNNKGQIKIADFGLARFYNPKSRPYTNKVITLWYRPPELLLGEERYGPSVDVWSCGCILGEFFTKKPIFQANSEINQLDLISQICGTPCPENWPSVVELPYYNNFKLRKY-ERRLEQEFHDLPELAVDLMQYMLILDPSMRYNAEQSLQHPFI Thecamonas_adhaerens_GI_196003954 YLKIEKIGEGTYGVVYKGKNRNTQQLVALKKIRLENEEEGIPSTAIREVSLLKELKHPNIVDLIEVLYEESKLYLVFEFLDMDLKRYLDTLPKTIDAMLMKSYLYQILLGVVYCHSHRVLHRDLKPQNLLINSKGCIKLADFGLGRAFGVPVRVYTHEVVTLWYRAPEVLLGSTRYSCPLDIWSTGTIFAEMWLRRPLFQGDSEIDELFRIFRILGTPDDDIWPGVSSLPEFKSS-FPKWSKQSYDTFVPNMSESGIDLLSKMLIYDPANRISGKRALSHPYF Thecamonas_adhaerens_GI_196010283 FDKLNRIGEGSYGVVYRARDLDSKEIVAIKKIRMENERDGIPVSSLREITLLVNLKHINIVNLKDVVVGLDSIFLVMEYCEQDLSSLLYNMKAPFTEPQVKCLSLQLIHGVQYLHHNFVIHRDLKVSNLLLTDKGILKVADFGLARNYGLPAAPMTPTIVSLWYRAPEVLLGCTKHTLAVDMWSVGCIIAELFDHNVFLKGKSEKDQLDLMCQMLGTPNEAIWEDIRDMPLYGKIILRQQPYNNLKHKFSWLSAAGLNLLNSLLTYDPGRRITADETLKLSYF Thecamonas_adhaerens_GI_196013334 FEWLNRIEEGTYGVVYRAKDLKSDEVVALKRLKMEKEREGFPITSLREINTLLKADHPNIVHVREIVVGMDKIYIVMEYVEHDLKTLMESMSQPFSISEVKCLMKQLLSAVQHLHDNWILHRDLKTSNLLLSHQGILKVGDFGLAREYGSPLKVYTSIVVTLWYRCPELLLGVKEYSTAVDMWSVGCIFGEFLVKKPLFPGKSEIDQLNKIFKDLGTPNDQIWSGFSELPVAKKVTFTEQPYNRLRDRFGYLTDQGFDLLNRFLTYDPKKRISAEDALNHEYF Thecamonas_adhaerens_GI_196013348 FHKLEKIGEGTYGKVYKACNKITGQTVALKKIRLDSDKEGVPSTTLREISILRSLNHSFVVRLYDVVHSDQCLYLVFEYLDHDLKHYLDHA-YKIPPALLKSYLYQMLRAISYCHSRRVLHRDLKPQNLLIDSTGTLKLADFGLARIFGLPVRQYTHEVITLWYRAPEILLGSTYYSTPVDIWSIGCIFVEMINRRPLFAGDSEIDQLFRVFRTLGTPDEITWPGVSEMSDYKST-FPKWPSRDLNSVIYSHDEDCVDLIKQMLVYEPNGRISARLALQHPYF Thecamonas_adhaerens_GI_196015356 FEFECKVGRGTYGHVYKAKMKSSGKEYALKLI----EGSGISMSACREIALLREVHHPNVISLQGVFLTNRKVWLLFDFAEHDLWHIIKYHAISLDSKMVKSLLKQILEGIHYLHANWILHRDLKPANILVMERGRVKIADMGFARHYWSPLKPLDPVVVTSWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQERDQLERIFMVMGYPHEKDWEDIKKTPNYAKLAFRKITNCSLAKYMIKQDSKEFILLQKCLTIDPNKRISSEQAIDDAYF Thecamonas_adhaerens_GI_196015366 FDFECKVGRGTYGHVYKAKMKTSGKEYALKLI----EGTGISMSACREIAILREISHTHVISLQGVFLTSRKVWLLLDFAEHDLWHIIKFHSVPIDTKIVKSLLRQILDGIQYLHSNWILHRDLKPANILVMERGRVKIADMGFARHFWAPLKPLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEHDQLDRIFTVMGFPHERDWEDIKIMPEYKRLQFKKPASCSLAKYMIRHDSREFSLLQKFLIADPNKRISAELAMDDAYF ; END; BEGIN TREES; Title Figure_1_Alignment_of_metazoan_CDK_BI; LINK Taxa = Taxa; TRANSLATE 1 Amphimedon_queenslandica_GI_340369066, 2 Amphimedon_queenslandica_GI_340369314, 3 Amphimedon_queenslandica_GI_340371337, 4 Amphimedon_queenslandica_GI_340373367, 5 Amphimedon_queenslandica_GI_340377126, 6 Amphimedon_queenslandica_GI_340379293, 7 Amphimedon_queenslandica_GI_340380476, 8 Amphimedon_queenslandica_GI_340381019, 9 Amphimedon_queenslandica_GI_340381980, 10 Amphimedon_queenslandica_GI_340383363, 11 Amphimedon_queenslandica_GI_340384408, 12 Homo_sapiens_CDK1, 13 Homo_sapiens_CDK10, 14 Homo_sapiens_CDK11B, 15 Homo_sapiens_CDK12, 16 Homo_sapiens_CDK13, 17 Homo_sapiens_CDK14, 18 Homo_sapiens_CDK15, 19 Homo_sapiens_CDK16, 20 Homo_sapiens_CDK17, 21 Homo_sapiens_CDK18, 22 Homo_sapiens_CDK19, 23 Homo_sapiens_CDK2, 24 Homo_sapiens_CDK20, 25 Homo_sapiens_CDK3, 26 Homo_sapiens_CDK4, 27 Homo_sapiens_CDK5, 28 Homo_sapiens_CDK6, 29 Homo_sapiens_CDK7, 30 Homo_sapiens_CDK8, 31 Homo_sapiens_CDK9, 32 Homo_sapiens_CDKL1, 33 Homo_sapiens_GSK3alpha, 34 Homo_sapiens_MAK, 35 Monosiga_brevicollis_GI_167516186, 36 Monosiga_brevicollis_GI_167516210, 37 Monosiga_brevicollis_GI_167516962, 38 Monosiga_brevicollis_GI_167517533, 39 Monosiga_brevicollis_GI_167522415, 40 Monosiga_brevicollis_GI_167522771, 41 Monosiga_brevicollis_GI_167525607, 42 Monosiga_brevicollis_GI_167525918, 43 Monosiga_brevicollis_GI_167536606, 44 Monosiga_brevicollis_GI_167538010, 45 Nematostella_vectensis_GI_156349526, 46 Nematostella_vectensis_GI_156360882, 47 Nematostella_vectensis_GI_156365870, 48 Nematostella_vectensis_GI_156374066, 49 Nematostella_vectensis_GI_156383566, 50 Nematostella_vectensis_GI_156385093, 51 Nematostella_vectensis_GI_156391793, 52 Nematostella_vectensis_GI_156392090, 53 Nematostella_vectensis_GI_156398520, 54 Nematostella_vectensis_GI_156403969, 55 Nematostella_vectensis_GI_156407302, 56 Nematostella_vectensis_GI_156408568, 57 Salpingoeca_rosetta_GI_326426444, 58 Salpingoeca_rosetta_GI_326430756, 59 Salpingoeca_rosetta_GI_326431660, 60 Salpingoeca_rosetta_GI_326434528, 61 Salpingoeca_rosetta_GI_326436991, 62 Salpingoeca_rosetta_GI_326436992, 63 Thecamonas_adhaerens_GI_195996637, 64 Thecamonas_adhaerens_GI_195996663, 65 Thecamonas_adhaerens_GI_195998898, 66 Thecamonas_adhaerens_GI_195999760, 67 Thecamonas_adhaerens_GI_196000717, 68 Thecamonas_adhaerens_GI_196001193, 69 Thecamonas_adhaerens_GI_196001971, 70 Thecamonas_adhaerens_GI_196002669, 71 Thecamonas_adhaerens_GI_196003954, 72 Thecamonas_adhaerens_GI_196010283, 73 Thecamonas_adhaerens_GI_196013334, 74 Thecamonas_adhaerens_GI_196013348, 75 Thecamonas_adhaerens_GI_196015356, 76 Thecamonas_adhaerens_GI_196015366; TREE '[1]Tree1' = ((34:0.884985,(32:0.798028,33:0.950484)1:0.185902)1:0.009333079,((64:0.418034,(36:0.435605,58:0.40015)0.88:0.100133,(9:0.215464,(24:0.240841,56:0.126784)0.86:0.050155)0.97:0.056692)1:0.455657,(((43:0.517355,60:0.337341)1:0.233851,(4:0.32326,(46:0.143944,(29:0.113972,69:0.215394)0.85:0.058487)0.72:0.054436)1:0.200065)1:0.241482,(((42:0.652534,(22:0.034788,(30:0.026951,(7:0.131684,(75:0.091477,76:0.109547)1:0.12471)0.71:0.043438)0.51:0.023983)1:0.366767)1:0.564746,((41:1.38146,((65:0.209454,(5:0.244114,(31:0.108352,47:0.164341)0.96:0.042787)0.94:0.080833)1:0.359902,(2:0.236986,((35:0.658776,70:0.129256)1:0.150746,(53:0.146011,(15:0.048272,16:0.044807)1:0.083132)0.65:0.05151)1:0.117607)1:0.242149)0.84:0.102873)1:0.178476,((44:0.43204,(10:0.140199,(14:0.093003,(49:0.14577,73:0.098695)1:0.051903)1:0.050316)0.69:0.075451)1:0.226302,((37:0.399687,59:0.383249)1:0.15053,(3:0.315283,(72:0.290019,(13:0.205729,45:0.205653):0.054392)0.93:0.058321)1:0.052691)0.54:0.123401)1:0.200727)1:0.146128)0.95:0.139239,(((26:0.223444,28:0.177226)1:0.130299,(48:0.28413,66:0.507538)1:0.130139)1:0.515815,((61:0.440124,((38:0.172746,62:0.165788)1:0.10191,((8:0.259515,(51:0.242594,(12:0.148714,71:0.228961)0.84:0.056035)0.65:0.029174)1:0.133613,(74:0.340113,(6:0.261146,(50:0.160809,(23:0.111417,25:0.1806)1:0.066248)0.73:0.028338)0.55:0.040519)1:0.081871)0.61:0.039221)0.94:0.085562)0.93:0.066392,(((40:0.253062,57:0.634576)1:0.207506,(67:0.390266,(11:0.250841,(27:0.117293,55:0.094037)0.87:0.045394)0.69:0.057487)1:0.136324)0.93:0.084708,((39:0.341851,(68:0.275368,(52:0.296175,(17:0.135626,18:0.230683)1:0.104896)0.62:0.052245)1:0.224095)0.64:0.056675,(1:0.230166,(63:0.212665,(19:0.087799,(21:0.145346,(20:0.055839,54:0.195437)0.94:0.034622)0.89:0.021192)1:0.058433)1:0.069562)1:0.06101)1:0.291085)1:0.106437)0.92:0.094629)1:0.182388)0.96:0.101262)0.86:0.077816)0.54:0.22710492); END;