#NEXUS [written Mon Sep 24 18:01:22 EDT 2012 by Mesquite version 2.75 (build 564) at BIO-SEKELSKYL07-7479/152.2.14.238] BEGIN TAXA; TITLE Taxa; DIMENSIONS NTAX=25; TAXLABELS Homo_sapiens_MCM8 Danio_rerio_MCM8 Strongylocentrotus_purpuratus_MCM8 Dictyostelium_discoideum_MCM8 Arabidopsis_thaliana_MCM8 Drosophila_melanogaster_REC Drosophila_pseudoobscura_REC Drosophila_virilis_REC Glossina_morsitans_REC Anopheles_gambiae_MCM8 Aedes_aegypti_MCM8 Culex_quinquefasciatus_MCM8 Homo_sapiens_MCM5 Danio_rerio_MCM5 Strongylocentrotus_purpuratus_MCM5 Drosophila_melanogaster_MCM5 Drosophila_pseudoobscura_MCM5 Drosophila_virilis_MCM5 Glossina_morsitans_MCM5 Anopheles_gambiae_MCM5 Aedes_aegypti_MCM5 Culex_quinquefasciatus_MCM5 Arabidopsis_thaliana_MCM5 Dictyostelium_discoideum_MCM5 Methanopyrus_kandleri_MCM ; END; BEGIN CHARACTERS; TITLE 'MCM5 + MCM8 metazoans MCM domain alignment'; DIMENSIONS NCHAR=720; FORMAT DATATYPE = Protein GAP = - MISSING = ?; MATRIX Homo_sapiens_MCM8 EPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGE-IQSFPLPDGK--YSLPTKC------PVPVCRGRS--FTALRSSPLTVTMDWQSIKIQELMSDDQRE-AGRIPRTIECELV-HDLVDSCVPGDTVTITGIVKVSN-----AEEGSRNKN--------DKCMFLLYIEANSISN-----------SKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAE--ENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYA---DDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCG--NTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQ-GICGIDEFDKMGNQHQALL-EAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAG----------KQRTISSATVARMNSQDSNTSVLEVV-----------------------------------------SEKPLSERLKVVPGET--IDPIPHQLLRKYIGYARQYVYP----RLSTEAARVLQDFYLELRKQSQRL---------------------------------------------------NSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSML------------------ Danio_rerio_MCM8 EPLTPLKSLRANLYGKFVVIRGTVVRVSNIKPLCMKLAFVCNSCGD-TQSVTLPDGK--YTMPTKC------LQSECRGRS--FTPNRSSPFTLTVDWQTIKVQELMSGDQRE-SGRIPRTIECELT-QDLVDSCVPGDMVTITGVIKVSN-----EEGSTRNKK--------DKCMFLLYIQANSVSN-----------SKGQKSKAVSESEGQGPSVEFSIKDLYAIQEIQAQ--EDLFKLIVNSLCPVIYGHLLVKAGLALALFGGCQKYV---DDKNRIPIRGDPHMLIVGDPGLGKSQMLQAVCNVAPRGVYVCG--NTTTTSGLTVSLSRDSGSGDYALEAGALVLGDQ-GICCIDEFDKMGSQHQALL-EAMEQQSISLAKAGIVCTLPARTSIIAAANPVGGHYNKGKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVMAMRAG----------KSGAVSGAAATRFNTHESSISILEVS-----------------------------------------SEKPLADTLKLVPGEA--FDPIPHQLLRKYVGYARHYVHP----TLSAEAAQVLQDFYLELRKQNQTA---------------------------------------------------DSTPITTRQLESLIRLTEARARVELREKATQSDAEDVVEIMKHSLT------------------ Strongylocentrotus_purpuratus_MCM8 EPTTAFKNLKANCYGKFVSVKGTVVRVSNIRPLCTKMAFQCNTCGD-IQIVHLPNGK--YILPTKC------LAPECRGRS--FVPKQKSPLTETADWQTIKLQEIVMDEQRE-AGRIPRTVECELM-HDLVDNCVPGDTVTVSGIVKVSN----VDEGKGRNK---------DKCMFLLYIHANSLSN----------LKKSKKGSDVSGGIGAGAAVDFSIKELYAIQEIQSQ--ENLFKLIIGSLCPTIYGHELVKAGLILGLLGGTHKYT---NDKNRIPVRGDPHILVVGDPGLGKSQMLQAASNVAPRGVYVCG--NTTTTSGLTVTLTKDGSSGDYSLEAGALVLGDQ-GCCCIDEFDKMGSQHQALL-EAMEQQSISIAKAGVVCSLPARTSILAAANPVGGHYNKAKTVSENLKMSGPLLSRFDLVFILLDKPDEEMDSLLSEHVMALHAG----------KQKAMSGVRVTRHPSGSITTSEDEDA------------------------------------RRLWESERPLSERLKVGRGEA--FDPIPSQLLRKYIAYARKYVYP----KLMPEAATVLQNFYLELRRQHQGM---------------------------------------------------DSTLITTRQLESLMRLTEARARLELREQATLADAEDVVELMKFSMI------------------ Dictyostelium_discoideum_MCM8 EPLLQLKKLKANLIDKFVSLKGTVIRVGNVKPLVTQMQFICNKCSTRTPTQYFTEGK--VTFPSNC------LNHGCRGKI--FEPDRST--AVTIDWQKIRIQE--DADQKE-SSGIPKAFECEIT-DEMVETIVPGDIVTISGVVKVLR----AEETGFQNQ---------NKPVFLIYIDVNSIDS----------------PKRTSGNGGKIETTSFSLKDMYGIKEIAEH--PNIFKLISNSICPTIYGHELVKAGLTLALFGGSPNRSSNGSDKNKLSIRSDPHVLIVGDPGLGKSQMLTSIYHLSPRGVYVCG--GYSSTTGLTVTLLREKGSGDFAIEAGALVLADQ-GCCCIDEFDKMTDEHPALL-EAMEQQSVSIAKAGIVCNLPARTSVVAAANPVGGHYNRAKTVSENIKMSAPLLSRFDLIFILMDKPNTEKDHIISHNILNLHSNGS-----GVKKRKPQQSSSSSSATTNSSQYTHEEDHD----------------------------------------KSLPLKQKLLITHGQE--INLIPTVILRKYISYAKKYVSP----RLSEEAIKVIQKFYLELRSKSTGS---------------------------------------------------DSMPVTTRQLESLIRLAEARAKLELRETVTEQDAIDIVEIMRDSLL------------------ Arabidopsis_thaliana_MCM8 ESSISLKNLRAAYIGKLVTVHGTVVKVSTVKPLVTQMAFDCGKCKT-GITREFTDGK--FSPPLKC------DSHGCKSKT--FTPIRSS--AQTIDFQKIRVQELQKPEDHE-EGRVPRTVECELM-EDLVDICIPGDVVTVTGIIGVINN--YMDIGGGKSKTK-------NQGFYYLFIEAVSVKNTKRQSA----FENSEDSSSSAQTADVGDLYSFSQRDLEFIVKFKEEYGSDTFRRILHSVCPSIYGHEIVKAGITLSLFGGVRKHS---MDRNKVPVRGDIHVIIVGDPGLGKSQLLQAAAAISPRGIYVCG--NATTRAGLTVAVVKDSMTNDYAFEAGAMVLADG-GLCCIDEFDKMTTEHQALL-EAMEQQCVSVAKAGLVASLSARTSVIAAANPVGGHYNRAKTVNENLKMSAALLSRFDLVFILLDKPDELLDKQVSEHIMSHH------------RMLGMQTCMQKGILYFQDCG-----------------------------------------------------------------WTLRKMTTFLRFLANCLGNIFPMHGILMSKDAGEIIQKFYLKLRDHNTSA---------------------------------------------------DSTPITARQLESLVRLAQARARVDLREEITVQDAMDVVEIMKESLY------------------ Drosophila_melanogaster_REC VPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQM-EIAMRQRGTF--QPRPYQC------KRSECVARDE-FVPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMPAEMDVELR-HDLVDAVRVGQEVVVTGILKLQE----LGDDTTTGD---------TSNQMQPYLKAVSIRD------------------------ASSIKREFSERDLEAIVMINAE--PNSFKLLVQSIAPEVYGHELPKAACLLSLLGGKGAET------------EAINVLLVGDPGIGKTKILQSCAQIAERGAHVSG--KRGAQSAQQLGVTFAGRNKR-VLQAGSLMMASGGGHCTLDDVDKLASKQAVLL-QCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSE-RDMSLTAHVRALHAG---------ARKRARIAARYALKPKMSDSMCEV---SLNVPAAGKDDDTIKTEDDNDSIMQ----------------QDYDLDKRLEVLPEEG-DLDLLPPILIKKFLSYARQELNP----VLNEDASNAVLRYFLELKGSCNLD----------------------------EDVS---------------------SQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESIT------------------ Drosophila_pseudoobscura_REC TPVELTTGISADRVDTLFSVRGIVSSVGEPTYSIAWQSFRCSRCQT-EQAMRQRGSF--QPRPYHC------KQAQCVAKDS-FVPLRSSPYTRISAKQIVRLEESSLSLIADYDSILPGEIDVELR-HDLVDCVHVGQEIVVNGVLKLRD----LGEDVTSATGSVAG----DSNELKAYLKAASVQD------------------------ARHKKREFSERDLEAIAMINAE--PNSFKLLVQSLAPEVHGHELPKAACLLSLLGGGA---------------GGVNVLLVGDPGIGKSKILQNCAQITERGSHISG--KRGAQSAQRLGPTFTGRNKR-VLQAGGLMTASSPGHCTLDDVDKLASKQAVLL-QCMQSGEINMPLPGAFSTFLAQPSIIACANPQRGQYDEGRYLLQNIHIVPSLLKEFHLVYVLLDKPSVVRDISLTAHVRALHAG---------AKKRAQIAARYALKPKTSDSMCEG---TFY--DVRADDDS----EDNDSIMQ----------------QDYDLDKRLELQEEDA-ELDLLPPILIKKFLAYARQNVNP----LLNEAASRSIERFFMELREGGRTGGG--------------------------EDT--------------------EQSQLGSGQLLGLIHLSQARARLDLSNVVTPQHVRDVIALLTESIT------------------ Drosophila_virilis_REC VPVELVSSITHARVDSLFAVRGIVRSVGEPTLGLAWQAFRCTRCRT-EQTLRQRGNY--TPRPYHC------LKPRCGAKDN-FLALRSSPYTRLSVRQIIRLEESSLALLTDYDSTLPGELDIELR-HDLVDAVHVGQEIIVTGVVKLRE----LCDNSEQPSTSVGAATTTASGNLQVYLRACSVQQ------------------------ARHVKLEFSERDLEAISTINTE--PNCFKLLVQSLAPELHGHELAKAACLLSLLG------------------ENINVLLVGDPGIGKSMMLQNCAQITERGAHVSG--KRGAQAANQLGISFCGRNKR-VMDAGALLMAGTAGTCLVDGVDKLASKQTLLL-QCMQAGELNMPLPGLFASFEAQPAIIACANPQRGQYDQARYLLQNIRITAALLKEFHLVYVLLDRQSTTRDKSLTEHVRALHAG---------SKRREQIAARYALKPKKSESVCEA---TFH-------DAPVVPNDDKDSIMQ----------------QDYDLDKRLECNVLEP-ELDLLPPILMKKFIAYARQNVKP----LLNDEAANIIKWHFMELCRRSELE--------------------------------------------------HEQSQIGMGQLLGLISLSQARARLDLSSVVTPLHVRDVIAVLTESMA------------------ Glossina_morsitans_REC QPMEQIPLME---IDQLYCVRGVVKSMGEVEAYASWVAYKCSRCKQ-DQALRQGDLQ--PNRPTSC------KTLGCMAKQG-FIEMRSSPFTRLKVKQIIELAEARLDVLHYEDTSIDYCLEAELH-YDLVDSVVIGEEVVMTGVLKMRS----LQEVAGGRQMKV-------------YLKVCSITK------------------------AERAPHHFNETDIQAITTINGA--ADSFKLLVHSLAPEVYGHEVVKAGALLSIIGGSGSQL---------HDEEDINVLLIGDPGVGKSRIAKMCAQISQKGNEISSIKQGLAGCGPKLTATVKGRLNS-ILESGGLLRGNK-GHCSIDDIDRLSSQQDALV-SLMQTQIVAIPTVAIYANLKASTSVIATANSMHGHYDQSKLLTNNIRISPTLLNEFHLIFLMLDKPNKEGDAIFSEHVRAVHGG---------FKKNSTIMNKFNTLPKFNNTVSEK---DWS----------------VENI------------------KSTDLIERLKLRADEGEELDLIPSMLLKKFA-YARQQVKP----LFIAEAAEDLQKFYMEIRGQQQSE---------------------------------------------------------EDHLAGLIRLCQARARIDFSTEVTKVHVYDVISLVKYSNA------------------ Anopheles_gambiae_MCM8 GPEVSISSIKVSSMGKLVSVRGTIIRAGATQIMNTWCAFRCAQCGS-EQAVQQKDGI--YTTPTSC-------HSGCKARSH-FVLLQQSAFTRMEAYQTLRLQETTQGSRTV-AGSAAKNIEIELT-HELVDSVCPGDDVTVTGILKARS-----QDGSDGAGK---------ASMFKAYLQAVYVRS------------------NKNVLANWNRLAEFTELDMEAIRLIKAE--PSPFRLLVQSLCPTIYGHEIVKAGLLLGLFGGMANTA---------RTRAEIHVLVVGDPGIGKSQILQSCANVSPRGIFVCG--TNSSNVGLTVTVRTEKGVGA-SLEAGALVLADQ-GVCCIDEFDKMSG-HSGLL-EVMEQRSVSVAKAGVICTVPARTTVLAAANPAGGHYNKAKTVSENLKLHPALLSRFDLVFILLDRSNERTDNLLTAHIQKVHGLA------KAGSSHLQPQPSHPFFDASGHCSYEE-------------------------------------------EGEPPLEERLRLAPGEQ--MDLLPPEIVQKYIGYARKNVQP----KLTAKAAEELREFFVELRRAHNHM---------------------------------------------------DMIPVTTRQLEGLIRLTQARAKIDLSPEATVAHVRDVLAILRQSML------------------ Aedes_aegypti_MCM8 GPEVHLRHMKINSFGKLFAVRGTIIRAGNSQVLNSWMAFRCSLCHG-QQAIRQTDGM--LTLPTSC-------REGCKARSN-FIPLRSSVFTRTEAFQTVRLQESMLGARSG-HGQVPRSIEVELT-HELVDAVCPGDDVTITGILKGRP----QEENSSKART--------TASMYKMYMQAVAVRS------------------NKNSLASWHRAAEFSDLDMEAIRMIRSE--PCPFRLLVQSLCPMIYGHEMIKAGLLLGLFGGASITK---------GRRSEIHVLIVGDPGIGKSQMLQSCAEVSPRGIFVCG--NSTSNAGLTVAVRTEKCTGG-ALEAGALVLADQ-GACCIDEFDKMSGNHQILL-EAMEQQVVSVAKAGVICSLPARTCILAAANPSGGHYDKSKTVSENLKMKPALLSRFDLVFIQLDRPNAHLDNLLAAHVQRLHGM--------QNGQQPQGAAFQALLIGMGTTTIHGS------------------------------------------QAETPLHERLKIRANEK--MDLLPVELIQKYIAYARKNIHP----KLTEAAALEIRNFYAEMRRAQQGM---------------------------------------------------DSIPVTTRQLEALVRLTQARARMDLESEATLQHAQDVIAILRYSMI------------------ Culex_quinquefasciatus_MCM8 GPEVHLRYLNINNWQKLIAVRGTITRAEGSIIISTWLTFRCSLCHG-LQVIRQPTGA--YAVPTSC-------RKGCKARSN-FVADRWSPYTRNEPFQKVRLQESNMGARSE-QGQVPRSIEVEFG-HELVDAVCPGDDVTVTGIVMCRS----QEENSSRANN--------SATMYKTYLKAVAVRS------------------NKNAKPGWHRGEEFTELDLEAVKAIRAE--PSVFRLMVQSLCPMIHGHEMIKAGLLLGIFGGSAIAG---------GRRSEIHVLVVGDPGIGKSQILQACARVSPRGIFVCG--NSTTNAGLTVNVRSEKGTGA-TLEAGALVLADQ-GVCCIDEFDKMSANNQVLL-EAMEQQVISVTKAGVMCTMPARTSILAAANPAGGSYDKSKTVSENIRMKPALLSRFDLVFTQLDQNDIQLDLMYTKHV-DLRGN---------LGTQD-GAALQALLTNGHHSSQPQSS------------------------------------------QAPPLHQSLKLRPGEK--MDTLPEELMQKYIAFTRKNINP----RLSREAAQELRSFYGEIRRAQQGM---------------------------------------------------HCFPVTTRQIEALIRLTQARARMDLVAEATVGHALDVIAILRFSMV------------------ Homo_sapiens_MCM5 ASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKC-NTDQAGRPKCPLDPY-FIMPDKC---KCVDFQTLKLQE--LPDAVP-HGEMPRHMQLYCD-RYLCDKVVPGNRVTIMGIYSIKKFG-LTTSRGRDRV---------GVGIRSSYIRVLGIQV------------------DTDGS-GRSFAGAVSPQEEEEFRRLAAL--PNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRL-----PDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSG--KGSSAAGLTASVMRDPSSRNFIMEGGAMVLADG-GVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETK-GEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLH----------------VSALTQTQAV--EGE---------------------------------------------------------------------IDLAKLKKFIAYCRVKCGP----RLSAEAAEKLKNRYIIMRSGARQHERDSD--------------------------------------------RRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTL------------------ Danio_rerio_MCM5 AHPASIRSLKSEQVSRLVKIPGIIISSTAVRAKATRVCLQCRGCRAVISNIPLPPGLQGYALPRKC-NTEQAGRVKCPVDPY-FIIPDRC---VCVDFQTQRLQE--APDAVP-HGEMPRHMQLYCD-RYLCDRVVPGNRVTVMGIYSIKKVA-QTKAKGRDKGT--------GVGIRSAYLRVVGIDV------------------DTEGA-GRGATGSVSPQEEEELRSLAAS--PSVYDSLARSLAPSIYGSDDLKKAIACLLFGGSRKRL-----PDGLTRRGDINLLMLGDPGTAKSQLLKFVERCSPIGVYTSG--KGSSAAGLTASVLRDPTTRGFVMEGGAMVLADG-GVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDDTK-GEDNIDFMPTILSRFDMIFIIKDHHDQQRDMTLARHVMNVHLS----------------AQTQTEGV--EGE---------------------------------------------------------------------IPLATLKKYIAYSRVKCGP----RLSAAAAEKLKNRYVLMRSGAKEHERETD--------------------------------------------RRVSIPITVRQLEAVVRIAESLAKMKLQPIAGEEEVDEALRLFQVSTL------------------ Strongylocentrotus_purpuratus_MCM5 ANPIAIRNLKSEEVSKLIKIPGIVIAASAIRAKATRITIQCRSCRNYMPNLTLKPGLEGYSMPRKC-NTDQAGRPKCPLDPF-FIVPDKC---KCVDFQILKLQE--APEDVP-NGEMPRHLQLFCD-RYLCEKVVPGNRVTIIGVYSIKKAGPVSKRTRKTKV---------TVGIRSPYIRVVGIEV------------------DQEGLGRTSTAHHITPQEEEEFRRLSAN--PNIYEIIARSIAPSIFGSIDVKKAISCLLFGGSRKRL-----PDGLMRRGDINLLMLGDPGTAKSQLLKFVERVSPIGVYTSG--KGSSAAGLTASVMRDPATRNFVMEGGAMVLADG-GVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDDTK-GDENIDFMPTILSRFDMIFIIKDEHDEARDMRLAKHVMGVHMN----------------AQVSAAALAQEGE---------------------------------------------------------------------LSLTFLKKYIGFIRNKCGP----RISDAAADKLKNRYVLMRSGARDHEMQTD--------------------------------------------KKTSIPITVRQLEAIIRIAESLAKMRLKPFASEEDVDEALRLFQVSTL------------------ Drosophila_melanogaster_MCM5 ANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYALPRKC-NTEQAGRPKCPLDPF-FIMPDKC---KCVDFQTLKLQE--LPDFVP-QGEIPRHLQLFCD-RSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKA---------VVGVRAPYMRVVGITV------------------DSEGAGAISRYSNITSDEEEHFRRMAAS--GDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRL-----PDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSG--KGSSAAGLTASVMKDPQTRNFVMEGGAMVLADG-GVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTK-GEENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLS----------------SNKSAPSEPAEGE---------------------------------------------------------------------ISLSTFKKYIHYCRTHCGP----RLSEAAGEKLKSRYVLMRSGAGQQEKASD--------------------------------------------KRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTL------------------ Drosophila_pseudoobscura_MCM5 ANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATKISIMCLSCSTVIPNLRVNPGLEGYAMPDKC-TTEQAGRPKCPLDPF-FVMPDKC---KCVDFQTLKLQE--LPDFVP-QGEIPRHLQLFCD-RSLCERVVPGNRVLIQGIYSIRKVGKPSRQDGREKA---------VVGVRAPYMRVVGITV------------------DAEGAGAISRYNNITTDEEDNFRRMAAS--GDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRL-----PDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSG--KGSSAAGLTASVMKDPQTRNFVMEGGAMVLADG-GVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTK-GEENIDFMPTILSRFDMIFIVKDVHDETRDITLAKHIINVHLS----------------SNKSAPTEPAEGE---------------------------------------------------------------------ISLSTFKKYIHYCRTHCGP----RLSEAAGEKLKSRYVLMRSGAGQQEKNAD--------------------------------------------KRLSIPITVRQLEAVIRISESLAKIRLLPFVADDHVNEALRLFQVSTL------------------ Drosophila_virilis_MCM5 ANPTNIRELKSDSVSRLVKIAGIIVAASGIQAKATRMSIMCRSCSTVIPNLKINPGLEGYALPRKC-TTEQAGRPKCPLDPF-FIMPDKC---KCVDFQTLKLQE--LPDFVP-QGEIPRHLQLFCD-RSLCERVVPGNRVLIQGVYSIRKVGKPSRQDGREKA---------VLGVRAPYMRVVGITV------------------DAEGAGAVSRYTNISTEEEENFRRIAAS--SDIYDRLSKSLAPSIFGSDDIKKAITCMLFGGSRKRL-----PDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSG--KGSSAAGLTASVMKDPHTRNFIMEGGAMVLADG-GVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTK-GEENIDFMPTILSRFDMIFIVKDVHDETRDITLAKHIINVHLS----------------SNKSAPFEPEEGE---------------------------------------------------------------------ISLPMFKKYIHYCRTHCGP----RLSEAAGEKLKSRYVLMRCGAGQQEKSAD--------------------------------------------KRHCIPITVRQLEAVIRISESLAKMRLLPFVMDDHVNEALRLFQVSTL------------------ Glossina_morsitans_MCM5 AIPTNVRDLKSDCVSRLVKIAGIIVSASGIKAKATRISIMCRSCGVVIPNLKINPGLEGYMLPRKC-TTEQAGRPRCPLDPF-FIMPEKC---RCVDFQILKLQE--LPDFVP-QGEIPRHLQLFCD-RTLCERVVPGNRVLIQGIYSIRKVGKPTRQDGREKS---------VVGVRAPYMRVVGITV------------------DTEGSGAISRYSNITSEEEETFRCMAAS--PTLYDRLASSLAPSIFGSHDIKRAITCMLFGGSRKRL-----PDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIGIYTSG--KGSSAAGLTASVMRDPSTRNFVMEGGAMVIADG-GIVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTINSRCSVLAAANSIFGRWDETK-GEENIDFMPTILSRFDMIFIIKDIHDEARDITMAKHIINVHLS----------------SNKSAPNEPAEGE---------------------------------------------------------------------ISLPLFKKYIYYCRTHCGP----RLSEEAGEKLKNRYVLMRNGAGQQEKSSD--------------------------------------------KRLSIPITVRQLEAIIRITESLAKMRLLPFATDEHINEALRLFQVSTL------------------ Anopheles_gambiae_MCM5 ANPTNIRDLKSDCVSKLVKVAGIIIAASGIKAKATRISIQCRTCNNVIPNLPVNPGLEGYQLPRKC-NTEQAGRPKCPLDPY-FIMPDKC---RCVDFQVLKLQE--LPDFIP-QGEIPRHMQLFCD-RSLCERVVPGNRVLIHGIFSIRKIARQGKRDGRDKA---------IIGVRAPYMRVVGITV------------------DTEGMGAISRFNNITSEEESTFRKLAAN--PNIYDTLADSLAPSIFGSQDIKKAITSMLFGGSRKRM-----PDGLTRRGDINILLLGDPGTAKSQLLKFVEKVAPIAVYTSG--KGSSAAGLTASVIRDPATRNFIMEGGAMVLADG-GVVCIDEFDKMKEDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTK-GDENIDFMPTILSRFDMIFIVKDEHDQQRDITLAKHVMSVHMN----------------ASKAT-AEPKEGE---------------------------------------------------------------------IPLAMLKKYIHYCRTHCGP----RLNEAAAEKLKSQYVRLRAGVGEHEKAID--------------------------------------------KRLSIPITVRQLEAIIRISESLAKMQLQPFATEAHVSEALRLFAVSTM------------------ Aedes_aegypti_MCM5 ANPTNIRDLKSECVSRLVKVAGIIIAASGIKAKATKISIQCRSCSNVIPNLPVNPGLEGYQLPRKC-TTEQTGRPKCPMDPY-FIMPDKC---KCVDFQVLKLQE--LPDFIP-QGEIPRHMQLFCD-RTLCERVVPGNRVLIHGIFSIRKIGKPSKQDGREKA---------IIGVRAPYMRVVGITV------------------DTEGMGSISRFSNITTEEESTFRKLAAN--PNIYDSLSESLAPSIFGSQDIKKAIVCLLFGGSRKRM-----PDGLTRRGDINILLLGDPGTAKSQLLKFVEQVAPIAVYTSG--KGSSAAGLTASVIRDPATRNFVMEGGAMVLADG-GVVCIDEFDKMKEDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTK-GEENIDFMPTILSRFDMIFIVKDVHDQARDITLAKHVMNVHMN----------------ANKTT-LETQEGE---------------------------------------------------------------------VPLALFKKYINYCRTHCGP----RLNEEAAEKLKSRYVLMRSGAGEHERMAD--------------------------------------------KRLSIPITVRQLEAVIRISESLAKMQLQPFATEAHVTEALRLFQVSTL------------------ Culex_quinquefasciatus_MCM5 ANATNIRDLKSECVSRLVKVAGIIISASGIKAKATRISIQCRTCSNVIPNLPVNPGLEGYQLPRKC-NTEQAGRPKCPLDPY-FIMPDKC---RCVDFQVLKLQE--LPDFIP-QGEIPRHMQLFCD-RSLCERVVPGNRVLIHGIFSIRKIGNPGKQDGREKA---------IIGVRAPYMRVVGITV------------------DTEGVGSISRFNNITIEEESMFRKMAAN--PNIYDTLTESLAPSIFGSQDIKRAIVCMLFGGSRKRM-----PDGLTRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSG--KGSSAAGLTASVMRDPATRNFVMEGGAMVLADG-GVVCIDEFDKMKEDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTK-GEDNIDFMPTILSRFDMIFIVKDVHDQARDMTLAKHVMNVHMN----------------ANKAT-VETQEGE---------------------------------------------------------------------VSLATFKKYINYCRTHCGP----RLNEGAAEKLKARYVTMRSGAGEAERQSD--------------------------------------------KRLSIPITVRQLEAVIRMSESLAKMQLQPFATEQHVTEALRLFQVSTL------------------ Arabidopsis_thaliana_MCM5 EDPVSMRLLGAQYISKLVKISGISIAASRVKAKATYVFLVCKNCKK-TREVPCRPGLGGAIVPRSCDNIPQPGEEPCPLDPW-MVVPDRS---QYVDQQTLKLQE--NPEDVP-TGELPRNMLLSVD-RHLVQTIVPGTRLTVMGIYSIFQ---ASSSSNSHKG---------AVAIRQPYIRVVGLED----------------TNEASSRGPA----NFTPDEEEEFKKFADS--QDVYKNICTKIAPSIFGHEDVKRAAACLLFGGSRKSL-----PDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSG--KGSSAAGLTASVIRDSSTREFYLEGGAMVLADG-GVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDIRKYSQDKEIASHIIRVHAS----------------ANKFSDENTDSKE-----------------------------------------------------------------------DNWLKRYIQYCRARCHP----RLSKDAAENLQRKYVTIRMDMKRRAHETG--------------------------------------------EAAPIPITVRQLEAIVRLSESLAKMRLSHEATPDDVDKAFKLFDTSTM------------------ Dictyostelium_discoideum_MCM5 ANPEPIRYLRAGLISKLVKVQGIVISASRTQPKPSTMVVKCKNCQH-TQTLHIRPGIVSSVLPQQCERGSNDAGKPCPNNPY-VVLSDQS---TFVNQQILKLQE--SPETIP-TGEMPRHIILSLD-KSLADKITPGTRIKVLGVLGIFE----GGGKRREIA---------GGTIRTNYLRVLGITS------------------DNAGRDSM----HFTPSEEQSFKVFSRR--QDLRNIIASSIAPSIYGHEDIKRAISCQLFGGSSKKL-----PDKMRLRGDINLLLLGDPGTAKSQLLKFVEKVAPISVYTSG--KGSSAAGLTASVIREPSTGEYYLEGGAMVVADG-GVVCIDEFDKMNVDDRVAIHEAMEQQTISIAKAGITTILNSRTSVLAAANPVYGRYNDA--ADDNINFQSTILSRFDLIFIVKDPKNEKRDFIISKHVINIHEK-----SSRSGGSGSVGNNTYDLSNTVVDDSH-------------------------------------------------IG-------------ENEVTIQYLKKYIAYARSRISP----RLSEDAVTTLKNHYVSVRAKSKEQEMINNGSYGGGGSKNSVETERKK--------------------------RKNAIPITVRQLEAIIRISESLAKMSLSPIATNEHAKEAIRLFDISTF------------------ Methanopyrus_kandleri_MCM -----MFRLGTTPRATTYDPDARIGEVASRFGLPTRVLIEIVRTESFQRSLARVTSGKPVVLDLRELDSDLASWIATHARLVEPALRELVRTVAPDVEPRVRFRG--LPHRFR-RVERIRPMDGALISIEGVVREVRGAERLEHAIVDTGSELVAVRLHGHRLGPG-------LRVEILGIVRSATLDA------------------LEVHKKDPIPEVHPDPAELEEFRELADK---DPLTTFARAIAP-LPGAEEVGKMLALQLFSCVGKNS------------ERLHVLLAGYPVVCSEILHHVLDHLAPRGVYVDL--RRTELTDLTAVLKED---RGWALRAGAAVLADG-GILAVDHLEGAPEPHRWALMEAMDKGTVTVDG----IALNARCAVLAAINP--GEQWPSDPPIARIDLDQDFLSHFDLIAFLGVDPRPGEPEEQDTEVPSYT--------------------------------------------------------------------------------------------------------LLRRYLLYAIREHPAP---ELTEEARKRLEHWYETRREEVEERLGMG----------------------------------------------LPTLPVTRRQLESVERLAKAHARMRLSDDVEPEDVDIAAELVDWYLETAMQIPGGDEIRISSLKP ; END; BEGIN ASSUMPTIONS; TYPESET * UNTITLED = unord: 1 - 720; END; BEGIN TREES; Title 'MCM5 + MCM8 metazoans ML tree'; LINK Taxa = Taxa; TRANSLATE 1 Homo_sapiens_MCM8, 2 Danio_rerio_MCM8, 3 Strongylocentrotus_purpuratus_MCM8, 4 Dictyostelium_discoideum_MCM8, 5 Arabidopsis_thaliana_MCM8, 6 Drosophila_melanogaster_REC, 7 Drosophila_pseudoobscura_REC, 8 Drosophila_virilis_REC, 9 Glossina_morsitans_REC, 10 Anopheles_gambiae_MCM8, 11 Aedes_aegypti_MCM8, 12 Culex_quinquefasciatus_MCM8, 13 Homo_sapiens_MCM5, 14 Danio_rerio_MCM5, 15 Strongylocentrotus_purpuratus_MCM5, 16 Drosophila_melanogaster_MCM5, 17 Drosophila_pseudoobscura_MCM5, 18 Drosophila_virilis_MCM5, 19 Glossina_morsitans_MCM5, 20 Anopheles_gambiae_MCM5, 21 Aedes_aegypti_MCM5, 22 Culex_quinquefasciatus_MCM5, 23 Arabidopsis_thaliana_MCM5, 24 Dictyostelium_discoideum_MCM5, 25 Methanopyrus_kandleri_MCM; TREE Imported_tree_0 = ((((((1:0.11079373,2:0.12659203)0.8940:0.0592661,3:0.16913702)0.9570:0.11348575,4:0.44132737)0.4970:0.09632478,5:0.52818436)0.7260:0.10908799,((((6:0.2159182,7:0.12415931)0.4550:0.08404008,8:0.21230169)1.0000:0.43391146,9:0.58503768)1.0000:0.66928667,(10:0.26969282,(11:0.10022856,12:0.29152596)0.9680:0.08977074)0.8560:0.16180074)0.9090:0.18889281)0.9650:0.44509851,((((13:0.11600401,14:0.14997354)0.9790:0.06673105,15:0.12324)0.8210:0.0415688,((((16:0.02191323,17:0.02336376)0.8680:0.02592887,18:0.03813234)0.9640:0.02573063,19:0.07699501)1.0000:0.05115367,(20:0.05872628,(21:0.02960792,22:0.04253459)0.5370:0.01828838)0.9980:0.06322941)1.0000:0.1113423)1.0000:0.16679895,(23:0.3356605,24:0.37998073)0.5540:0.11720663)0.9940:0.56867385,25:1.8825241); END; BEGIN CODONS; CODESET * UNTITLED = universal: 1 - 720; END; BEGIN MESQUITECHARMODELS; ProbModelSet * UNTITLED = 'Mk1 (est.)': 1 - 720; END; Begin MESQUITE; MESQUITESCRIPTVERSION 2; TITLE AUTO; tell ProjectCoordinator; timeSaved 1348524082598; getEmployee #mesquite.minimal.ManageTaxa.ManageTaxa; tell It; setID 0 5483103315002429434; endTell; getEmployee #mesquite.charMatrices.ManageCharacters.ManageCharacters; tell It; setID 0 4904332917991181579; mqVersion 275; checksumv 0 3 1673839923 null getNumChars 720 numChars 720 getNumTaxa 25 numTaxa 25 short false bits 1048575 states 1048575 sumSquaresStatesOnly 9.7619953650507E13 sumSquares 9.7619953650507E13 longCompressibleToShort false usingShortMatrix false NumFiles 1 NumMatrices 1 errorReportedDuringRun; mqVersion; endTell; getWindow; tell It; suppress; setResourcesState true false 100; setPopoutState 400; setExplanationSize 0; setAnnotationSize 0; setFontIncAnnot 0; setFontIncExp 0; setSize 1212 780; setLocation 194 60; setFont SanSerif; setFontSize 10; getToolPalette; tell It; endTell; setActive; desuppress; endTell; endTell; end;