#NEXUS [written Thu Dec 12 17:48:33 WET 2013 by Mesquite version 2.75 (build 566) at pjs-MacBook-Pro.local/10.10.6.137] BEGIN TAXA; TITLE Taxa; DIMENSIONS NTAX=355; TAXLABELS Pichia_stipitis_CBS_6054_pist_igi19985888 Saccharomyces_cerevisiae_S288C_sace0c00132g Saccharomyces_cerevisiae_YJM789_sace_e_3474 Pichia_stipitis_CBS_6054_pist_igi19987745 Pichia_stipitis_CBS_6054_pist_igi20837975 Saccharomyces_cerevisiae_S288C_sace0b09020g Saccharomyces_cerevisiae_EC1118_sace_b_1b15_4786g Saccharomyces_cerevisiae_JAY291_sace_c_01581 'Saccharomyces cerevisiae RM11-1A sace d 02679' 'Saccharomyces paradoxus NRRL Y-17217 sapa c84 2183' Candida_lusitaniae_ATCC_42720_calu_03396 Pichia_stipitis_CBS_6054_pist_igi20835632 'Candida tropicalis MYA-3404 catr 02586' Pichia_stipitis_CBS_6054_pist_igi19138887 Kluyveromyces_lactis_CLIB210_klla0b00352g 'Saccharomyces bayanus 623-6C saba a 556.17' Candida_albicans_SC5314_caal_a_19.304 'Candida albicans WO-1 caal b 02627' Candida_dubliniensis_CD36_cadu_83050 Debaryomyces_hansenii_CBS767_deha2d11572g 'Kluyveromyces waltii NCYC2644 klwa 034-snap.4' Candida_guilliermondii_ATCC_6260_cagu_00085 Candida_guilliermondii_ATCC_6260_cagu_05158 Kluyveromyces_thermotolerans_CBS6340_klth0c10560g 'Kluyveromyces waltii NCYC2644 klwa 042-snap.2' 'Kluyveromyces waltii NCYC2644 klwa 116-snap.16' 'Saccharomyces bayanus 623-6C saba a 673.19' Saccharomyces_bayanus_MCYC_623_saba_b_c773_24081 Saccharomyces_cerevisiae_S288C_sace0o12012g Saccharomyces_cerevisiae_JAY291_sace_c_04464 'Saccharomyces cerevisiae RM11-1A sace d 01751' Saccharomyces_cerevisiae_YJM789_sace_e_5421 'Saccharomyces paradoxus NRRL Y-17217 sapa c93 21663' Saccharomyces_kudriavzevii_IFO_1802_saku_c2036.7 Saccharomyces_mikatae_IFO_1815_sami_a_c511_20564 Saccharomyces_mikatae_IFO_1815_sami_b_c1722.1 'Saccharomyces castelli NRRL Y-12630 saca 696.43' Candida_dubliniensis_CD36_cadu_10040 Candida_guilliermondii_ATCC_6260_cagu_02196 'Kluyveromyces waltii NCYC2644 klwa 333-snap.4' Candida_albicans_SC5314_caal_a_19.2350 Candida_guilliermondii_ATCC_6260_cagu_05806 Pichia_pastoris_GS115_pipa_3g00675 Saccharomyces_kluyveri_CBS3082_sakl0d01386g Candida_guilliermondii_ATCC_6260_cagu_05180 Kluyveromyces_thermotolerans_CBS6340_klth0c03806g Pichia_stipitis_CBS_6054_pist_igi16597754 Kluyveromyces_polysporus_DSM_70294_klpo_541.16 Candida_glabrata_CBS138_cagl0l02519g 'Lodderomyces elongisporus NRRL YB-4239 loel 03562' Candida_parapsilosis_CDC_317_capa_03043 Debaryomyces_hansenii_CBS767_deha2c03718g Candida_glabrata_CBS138_cagl0b02343g 'Candida tropicalis MYA-3404 catr 05874' Saccharomyces_kluyveri_CBS3082_sakl0f00198g 'Saccharomyces castelli NRRL Y-12630 saca 551.4' Saccharomyces_kudriavzevii_IFO_1802_saku_c2070.4 'Saccharomyces bayanus 623-6C saba a 601.4' Saccharomyces_bayanus_MCYC_623_saba_b_c68_15452 Saccharomyces_cerevisiae_S288C_sace0m09768g Saccharomyces_cerevisiae_EC1118_sace_b_1m3_4896g Saccharomyces_cerevisiae_JAY291_sace_c_03767 'Saccharomyces cerevisiae RM11-1A sace d 02175' Saccharomyces_cerevisiae_YJM789_sace_e_4461 'Saccharomyces paradoxus NRRL Y-17217 sapa c419 17887' Candida_guilliermondii_ATCC_6260_cagu_04492 'Saccharomyces castelli NRRL Y-12630 saca 692.14' Saccharomyces_cerevisiae_S288C_sace0m00462g Saccharomyces_cerevisiae_EC1118_sace_b_1m3_0188g Saccharomyces_cerevisiae_JAY291_sace_c_04366 'Saccharomyces cerevisiae RM11-1A sace d 01783' Saccharomyces_cerevisiae_YJM789_sace_e_4060 'Candida tropicalis MYA-3404 catr 03278' 'Saccharomyces bayanus 623-6C saba a 671.27' Saccharomyces_bayanus_MCYC_623_saba_b_c753_19471 Saccharomyces_cerevisiae_S288C_sace0p10472g Saccharomyces_cerevisiae_EC1118_sace_b_1p2_5457g Saccharomyces_cerevisiae_JAY291_sace_c_02068 'Saccharomyces cerevisiae RM11-1A sace d 04120' Saccharomyces_cerevisiae_YJM789_sace_e_5897 Saccharomyces_kudriavzevii_IFO_1802_saku_c1565.3 Saccharomyces_mikatae_IFO_1815_sami_a_c468_17485 'Saccharomyces paradoxus NRRL Y-17217 sapa c565 22682' Saccharomyces_cerevisiae_JAY291_sace_c_05667 Saccharomyces_kluyveri_CBS3082_sakl0f00440g Saccharomyces_mikatae_IFO_1815_sami_a_c1152_6745 Saccharomyces_mikatae_IFO_1815_sami_a_c208_6715 Saccharomyces_mikatae_IFO_1815_sami_b_c2021.3 'Saccharomyces paradoxus NRRL Y-17217 sapa c345 7127' Saccharomyces_mikatae_IFO_1815_sami_a_c551_15970 'Saccharomyces paradoxus NRRL Y-17217 sapa c443 17778' Pichia_stipitis_CBS_6054_pist_igi16258608 Kluyveromyces_thermotolerans_CBS6340_klth0h16214g Pichia_stipitis_CBS_6054_pist_igi18293386 Yarrowia_lipolytica_CLIB122_yali0f06908g Pichia_pastoris_GS115_pipa_3g03370 Kluyveromyces_lactis_CLIB210_klla0c18931g Kluyveromyces_lactis_CLIB210_klla0f17776g 'Kluyveromyces waltii NCYC2644 klwa 298-snap.4' Pichia_pastoris_GS115_pipa_3g02865 'Saccharomyces bayanus 623-6C saba a 604.18' Saccharomyces_bayanus_MCYC_623_saba_b_c553_18284 Debaryomyces_hansenii_CBS767_deha2f27082g Candida_glabrata_CBS138_cagl0m03003g 'Kluyveromyces waltii NCYC2644 klwa 093-snap.33' Candida_albicans_SC5314_caal_a_19.7554 'Candida albicans WO-1 caal b 02248' Candida_dubliniensis_CD36_cadu_34960 Saccharomyces_kudriavzevii_IFO_1802_saku_c1455.3 Saccharomyces_mikatae_IFO_1815_sami_a_c1010_16957 'Saccharomyces bayanus 623-6C saba a 622.18' Saccharomyces_bayanus_MCYC_623_saba_b_c596_2320 Saccharomyces_cerevisiae_S288C_sace0m05214g Saccharomyces_cerevisiae_EC1118_sace_b_1m3_2575g Saccharomyces_cerevisiae_JAY291_sace_c_00976 'Saccharomyces cerevisiae RM11-1A sace d 01978' Saccharomyces_cerevisiae_YJM789_sace_e_4257 Saccharomyces_kudriavzevii_IFO_1802_saku_c1803.5 'Saccharomyces paradoxus NRRL Y-17217 sapa c170 16969' Zygosaccharomyces_rouxii_CBS_732_zyro0g03234g Candida_guilliermondii_ATCC_6260_cagu_00124 'Saccharomyces castelli NRRL Y-12630 saca 616.4' Candida_glabrata_CBS138_cagl0j01375g Candida_lusitaniae_ATCC_42720_calu_02219 'Saccharomyces paradoxus NRRL Y-17217 sapa c214 2150' Pichia_stipitis_CBS_6054_pist_igi19055263 Saccharomyces_kluyveri_CBS3082_sakl0c02178g Saccharomyces_kluyveri_CBS3082_sakl0e04246g Yarrowia_lipolytica_CLIB122_yali0e18095g Pichia_stipitis_CBS_6054_pist_igi19986138 Eremothecium_gossypii_ATCC10895_ergo0b04004g Debaryomyces_hansenii_CBS767_deha2e02794g Kluyveromyces_thermotolerans_CBS6340_klth0b00132g Kluyveromyces_thermotolerans_CBS6340_klth0b10142g Kluyveromyces_thermotolerans_CBS6340_klth0h05456g 'Saccharomyces castelli NRRL Y-12630 saca 660.3' Saccharomyces_mikatae_IFO_1815_sami_a_c699_5023 Pichia_stipitis_CBS_6054_pist_igi16259683 Saccharomyces_kluyveri_CBS3082_sakl0a08228g Yarrowia_lipolytica_CLIB122_yali0c22660g 'Kluyveromyces waltii NCYC2644 klwa 305-snap.8' Pichia_pastoris_GS115_pipa_1g01100 Saccharomyces_kluyveri_CBS3082_sakl0e02992g Kluyveromyces_lactis_CLIB210_klla0f13684g Kluyveromyces_thermotolerans_CBS6340_klth0d16962g Saccharomyces_mikatae_IFO_1815_sami_a_c322_9452 Candida_guilliermondii_ATCC_6260_cagu_01265 Kluyveromyces_thermotolerans_CBS6340_klth0c10142g Saccharomyces_kluyveri_CBS3082_sakl0a07480g Kluyveromyces_thermotolerans_CBS6340_klth0e16720g Candida_guilliermondii_ATCC_6260_cagu_04556 Candida_lusitaniae_ATCC_42720_calu_04865 Kluyveromyces_thermotolerans_CBS6340_klth0d05434g Zygosaccharomyces_rouxii_CBS_732_zyro0a00330g Zygosaccharomyces_rouxii_CBS_732_zyro0g21890g 'Kluyveromyces waltii NCYC2644 klwa 074-snap.3' Kluyveromyces_lactis_CLIB210_klla0a04631g Candida_dubliniensis_CD36_cadu_43440 Saccharomyces_mikatae_IFO_1815_sami_a_c124_14118 Saccharomyces_mikatae_IFO_1815_sami_b_c2470.1 Candida_albicans_SC5314_caal_a_19.1308 'Candida albicans WO-1 caal b 03443' Candida_lusitaniae_ATCC_42720_calu_02516 Saccharomyces_cerevisiae_S288C_sace0k07392g 'Saccharomyces cerevisiae RM11-1A sace d 05344' Saccharomyces_cerevisiae_YJM789_sace_e_0518 'Saccharomyces paradoxus NRRL Y-17217 sapa c403 13057' 'Saccharomyces paradoxus NRRL Y-17217 sapa c84 2187' Saccharomyces_cerevisiae_EC1118_sace_b_1k5_3763g Candida_guilliermondii_ATCC_6260_cagu_00118 Candida_parapsilosis_CDC_317_capa_01507 Candida_guilliermondii_ATCC_6260_cagu_04884 'Kluyveromyces waltii NCYC2644 klwa 281-snap.8' Candida_lusitaniae_ATCC_42720_calu_04792 'Kluyveromyces waltii NCYC2644 klwa 073-snap.6' Zygosaccharomyces_rouxii_CBS_732_zyro0c01430g 'Candida tropicalis MYA-3404 catr 05923' 'Kluyveromyces waltii NCYC2644 klwa 021-snap.20' Candida_guilliermondii_ATCC_6260_cagu_05184 Kluyveromyces_thermotolerans_CBS6340_klth0g13464g Debaryomyces_hansenii_CBS767_deha2e02948g Candida_lusitaniae_ATCC_42720_calu_00809 Kluyveromyces_polysporus_DSM_70294_klpo_416.6 Candida_parapsilosis_CDC_317_capa_02998 Saccharomyces_kluyveri_CBS3082_sakl0a00726g 'Candida tropicalis MYA-3404 catr 01806' Pichia_stipitis_CBS_6054_pist_igi16601804 Candida_dubliniensis_CD36_cadu_22250 Candida_guilliermondii_ATCC_6260_cagu_00173 Candida_lusitaniae_ATCC_42720_calu_04864 'Kluyveromyces waltii NCYC2644 klwa 018-snap.54' Candida_albicans_SC5314_caal_a_19.2179 Candida_albicans_SC5314_caal_a_19.7336 'Candida albicans WO-1 caal b 02209' 'Candida albicans WO-1 caal b 05897' Candida_parapsilosis_CDC_317_capa_02455 Saccharomyces_mikatae_IFO_1815_sami_a_c633_10615 'Saccharomyces bayanus 623-6C saba a 479.6' 'Saccharomyces bayanus 623-6C saba a 673.6' Saccharomyces_cerevisiae_S288C_sace0o00308g Saccharomyces_cerevisiae_EC1118_sace_b_1o4_0034g 'Saccharomyces cerevisiae RM11-1A sace d 01250' 'Saccharomyces paradoxus NRRL Y-17217 sapa c416 24437' Kluyveromyces_polysporus_DSM_70294_klpo_416.5 Kluyveromyces_thermotolerans_CBS6340_klth0d18150g Pichia_stipitis_CBS_6054_pist_igi19986137 Candida_parapsilosis_CDC_317_capa_02454 'Candida tropicalis MYA-3404 catr 03960' Yarrowia_lipolytica_CLIB122_yali0f28017g Pichia_stipitis_CBS_6054_pist_igi16603947 'Kluyveromyces waltii NCYC2644 klwa 265-snap.3' 'Candida tropicalis MYA-3404 catr 04131' Kluyveromyces_lactis_CLIB210_klla0d19941g 'Kluyveromyces waltii NCYC2644 klwa 298-snap.3' Saccharomyces_kluyveri_CBS3082_sakl0c12122g Yarrowia_lipolytica_CLIB122_yali0d15972g Yarrowia_lipolytica_CLIB122_yali0f20922g Saccharomyces_mikatae_IFO_1815_sami_b_c2470.2 Saccharomyces_cerevisiae_S288C_sace0g11000g Saccharomyces_cerevisiae_EC1118_sace_b_1g1_5567g Saccharomyces_cerevisiae_JAY291_sace_c_01814 'Saccharomyces cerevisiae RM11-1A sace d 00798' Saccharomyces_cerevisiae_YJM789_sace_e_2117 'Saccharomyces castelli NRRL Y-12630 saca 705.26' Kluyveromyces_thermotolerans_CBS6340_klth0a01562g Pichia_stipitis_CBS_6054_pist_igi16606996 Saccharomyces_cerevisiae_S288C_sace0c00110g Saccharomyces_cerevisiae_S288C_sace0k07414g Saccharomyces_cerevisiae_JAY291_sace_c_04015 'Saccharomyces cerevisiae RM11-1A sace d 05343' Saccharomyces_cerevisiae_YJM789_sace_e_0517 'Saccharomyces paradoxus NRRL Y-17217 sapa c403 13053' Kluyveromyces_thermotolerans_CBS6340_klth0d00506g Saccharomyces_kluyveri_CBS3082_sakl0g03300g Kluyveromyces_polysporus_DSM_70294_klpo_358.4 'Lodderomyces elongisporus NRRL YB-4239 loel 00428' 'Lodderomyces elongisporus NRRL YB-4239 loel 02353' Saccharomyces_kluyveri_CBS3082_sakl0f00792g Kluyveromyces_thermotolerans_CBS6340_klth0b00594g 'Kluyveromyces waltii NCYC2644 klwa 331-snap.3' Pichia_pastoris_GS115_pipa_4g02960 Yarrowia_lipolytica_CLIB122_yali0c16225g Candida_guilliermondii_ATCC_6260_cagu_04513 Kluyveromyces_thermotolerans_CBS6340_klth0a07964g 'Kluyveromyces waltii NCYC2644 klwa 001-snap.4' Candida_albicans_SC5314_caal_a_19.4779 'Candida albicans WO-1 caal b 00508' Candida_dubliniensis_CD36_cadu_08690 Kluyveromyces_thermotolerans_CBS6340_klth0b10450g Kluyveromyces_thermotolerans_CBS6340_klth0d00110g 'Saccharomyces castelli NRRL Y-12630 saca 663.28' Saccharomyces_cerevisiae_EC1118_sace_b_1h21_0023g Saccharomyces_kluyveri_CBS3082_sakl0e00132g Saccharomyces_kluyveri_CBS3082_sakl0f00110g Zygosaccharomyces_rouxii_CBS_732_zyro0g21868g Debaryomyces_hansenii_CBS767_deha2b16478g Debaryomyces_hansenii_CBS767_deha2g17402g Kluyveromyces_lactis_CLIB210_klla0c19272g Yarrowia_lipolytica_CLIB122_yali0f27709g Candida_glabrata_CBS138_cagl0b02079g Debaryomyces_hansenii_CBS767_deha2a03806g Kluyveromyces_lactis_CLIB210_klla0c00220g Kluyveromyces_thermotolerans_CBS6340_klth0g09504g Candida_parapsilosis_CDC_317_capa_05437 Kluyveromyces_polysporus_DSM_70294_klpo_513.33 'Lodderomyces elongisporus NRRL YB-4239 loel 05322' Yarrowia_lipolytica_CLIB122_yali0b19250g Candida_albicans_SC5314_caal_a_19.1942 'Candida albicans WO-1 caal b 04515' Candida_dubliniensis_CD36_cadu_51060 Kluyveromyces_thermotolerans_CBS6340_klth0b00110g Pichia_stipitis_CBS_6054_pist_igi16603948 'Saccharomyces bayanus 623-6C saba a 676.52' Saccharomyces_bayanus_MCYC_623_saba_b_c280_5966 Saccharomyces_cerevisiae_S288C_sace0h00308g Saccharomyces_cerevisiae_EC1118_sace_b_1h21_0100g Saccharomyces_cerevisiae_JAY291_sace_c_03075 'Saccharomyces cerevisiae RM11-1A sace d 04665' Saccharomyces_cerevisiae_YJM789_sace_e_2345 'Saccharomyces paradoxus NRRL Y-17217 sapa c38 10565' Debaryomyces_hansenii_CBS767_deha2e15070g Saccharomyces_cerevisiae_S288C_sace0e00330g Saccharomyces_cerevisiae_EC1118_sace_b_1e8_0089g Saccharomyces_cerevisiae_JAY291_sace_c_05195 'Saccharomyces cerevisiae RM11-1A sace d 04406' Saccharomyces_cerevisiae_YJM789_sace_e_1433 Saccharomyces_mikatae_IFO_1815_sami_a_c202_5644 'Saccharomyces paradoxus NRRL Y-17217 sapa c356 5984' Debaryomyces_hansenii_CBS767_deha2d01210g Saccharomyces_kluyveri_CBS3082_sakl0g06600g Yarrowia_lipolytica_CLIB122_yali0c06105g Kluyveromyces_lactis_CLIB210_klla0e09879g 'Saccharomyces castelli NRRL Y-12630 saca 713.30' Saccharomyces_kudriavzevii_IFO_1802_saku_c1947.4 Yarrowia_lipolytica_CLIB122_yali0c02541g Debaryomyces_hansenii_CBS767_deha2a14696g Saccharomyces_kluyveri_CBS3082_sakl0b12716g Candida_parapsilosis_CDC_317_capa_03952 'Lodderomyces elongisporus NRRL YB-4239 loel 04525' Pichia_pastoris_GS115_pipa_3g03640 'Saccharomyces bayanus 623-6C saba a 602.6' Saccharomyces_bayanus_MCYC_623_saba_b_c633_10089 Kluyveromyces_lactis_CLIB210_klla0a10439g 'Saccharomyces castelli NRRL Y-12630 saca 514.3' Saccharomyces_cerevisiae_JAY291_sace_c_05665 Saccharomyces_kudriavzevii_IFO_1802_saku_c1886.4 'Saccharomyces paradoxus NRRL Y-17217 sapa c345 7143' Yarrowia_lipolytica_CLIB122_yali0a10593g Candida_dubliniensis_CD36_cadu_34690 Candida_guilliermondii_ATCC_6260_cagu_04002 'Saccharomyces bayanus 623-6C saba a 601.3' Saccharomyces_bayanus_MCYC_623_saba_b_c68_15461 Saccharomyces_cerevisiae_S288C_sace0h00198g 'Candida tropicalis MYA-3404 catr 03958' Yarrowia_lipolytica_CLIB122_yali0d05401g Yarrowia_lipolytica_CLIB122_yali0d20350g Candida_lusitaniae_ATCC_42720_calu_01670 Candida_parapsilosis_CDC_317_capa_03962 Kluyveromyces_lactis_CLIB210_klla0e14609g Pichia_pastoris_GS115_pipa_2g00050 Candida_parapsilosis_CDC_317_capa_00064 Pichia_pastoris_GS115_pipa_3g01745 Yarrowia_lipolytica_CLIB122_yali0a14883g Kluyveromyces_polysporus_DSM_70294_klpo_543.44 Kluyveromyces_lactis_CLIB210_klla0d19945g Yarrowia_lipolytica_CLIB122_yali0d22913g Candida_glabrata_CBS138_cagl0e04092g Candida_guilliermondii_ATCC_6260_cagu_05301 Debaryomyces_hansenii_CBS767_deha2e02596g 'Saccharomyces paradoxus NRRL Y-17217 sapa c290 9193' Yarrowia_lipolytica_CLIB122_yali0f19118g 'Candida tropicalis MYA-3404 catr 00078' Kluyveromyces_thermotolerans_CBS6340_klth0c10120g Candida_parapsilosis_CDC_317_capa_02689 Debaryomyces_hansenii_CBS767_deha2c05390g Saccharomyces_kluyveri_CBS3082_sakl0h16808g Candida_guilliermondii_ATCC_6260_cagu_03941 Yarrowia_lipolytica_CLIB122_yali0a17149g Yarrowia_lipolytica_CLIB122_yali0d20196g Candida_dubliniensis_CD36_cadu_61510 Candida_albicans_SC5314_caal_a_19.3444 'Candida albicans WO-1 caal b 05224' Saccharomyces_kluyveri_CBS3082_sakl0c05588g Candida_parapsilosis_CDC_317_capa_02690 Eremothecium_gossypii_ATCC10895_ergo0g10076g Zygosaccharomyces_rouxii_CBS_732_zyro0g07414g 'Lodderomyces elongisporus NRRL YB-4239 loel 03789' Saccharomyces_mikatae_IFO_1815_sami_a_c1083_3691 Saccharomyces_cerevisiae_YJM789_sace_e_1018 Saccharomyces_kudriavzevii_IFO_1802_saku_c1927.9 Saccharomyces_cerevisiae_S288C_sace0d07920g Saccharomyces_cerevisiae_EC1118_sace_b_1d0_3730g Saccharomyces_cerevisiae_JAY291_sace_c_00011 'Saccharomyces cerevisiae RM11-1A sace d 00400' 'Candida tropicalis MYA-3404 catr 02833' ; END; BEGIN CHARACTERS; TITLE 'Additional_file_3_character_matrix'; DIMENSIONS NCHAR=1263; FORMAT DATATYPE = Protein GAP = - MISSING = ?; MATRIX Pichia_stipitis_CBS_6054_pist_igi19985888 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIPLILCTISIILSIFLTAIDQTVVITALAGIEEAFG------GASQ--IGWSTAGYVLPMAVLALFWGRFGLV-MGRKSSVLISIFFFEVGSLICALSK-----SMGMFIGGRVITGIGAGGIQTNVFMISSEITPLN--QRGIIIAFVTMSLIPAA--VIGPVIGGLFTS-----SKTLTWRW-CF---YINLPFGGVAALFLSLLY-------KPK----------ND--------------------------------------------------------------------------------------KSRFI--------WN----WNKTIF-----------KRLVNTFDLVGVLLVGISLVLFLVGCSLGGT------GLN----GFNK------PVTICFTIIGGVL-F-LCFIY--YE-FYCYKVNQ------------E-----MHY-Y----------P-MLPKELI-FKRQVLAPGLIMLLSNMVF-NGSSIYISIYFENLLGNSPSRTGVHLLPMILPTIL-TTMISGLICS-K---------VGIV-KPVLIFGSIC-GVISSGLI-----TML----------------------------NY--H------SSD--GEKIGFLFLVGFSFGFFNQ-ASMIAAQLSVS-EDQTD---YTLIITSFTAFMRSFGASLGGIVLTSI-Y--SNTV-NKELQKYPQF-------------------REETVDQILKNGSLQGFD----------------QHEASILINA-LSIGLKWVFHSILILSVSCLFI--SFTTSN---A---RV-------------------------------------------------------PQKKKEDTDIVEA-------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_S288C_sace0c00132g -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNMLIVGRVVASVGGSGLQTLCFVIGCTMVGER--SRPLVISILSCAFAVAA--IVGPIIGGAFTT--H--V---TWRW-CF---YINLPIGGLAIIMFLLTY-------KAE----------NK-----------------------------GILQQIKDAIGTISSFTFSKFRHQVN-------------------------------FKRLM--------NG--------II-----------FKF----DFFGFALCSAGLVLFLLGLTFGG-------NKY----SWNS------GQVIAYLVLGVLL-F-IFSLV--YD-FFLFDKFNPEPD--------N-----ISY-R----------P-LLLRRLV-AKPAIIIINMVTFLLCTGY-NGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVI-AAIASGVITK-K---------LGLV-KPLLIFGGVL-GVIGAGLM-----TLM----------------------------TN--T------STK--STQIGVLLLPGFSLGFALQ-ASLMSAQLQIT-KDRPEAAMDFIEVTAFNTFMKSLGTTLGGVLSTTV-F--SASF-HNK----VSR---------AHLEP----YEGKTVDDMILY-RLQNYD-------------GSHSTIGNILSDS-----IKNVFWMDLGFYALGFLF--CSFSSN---K---KL-----IIP-----------------------------------------------KKDETPEDNLEDK-------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_YJM789_sace_e_3474 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGER--SRPLVISILSCAFAVAA--IVGPIIGGAFTT--H--V---TWRW-CF---YINLPIGGLAIIMFLLTY-------KAE-------------------------------------------------NKGILQQIKDAIGTISSFTFSKFRHQVN---------------------FKRLM--------NG--------II-----------FKF----DFFGFALCSAGLVLFLLGLTFGG-------NKY----SWNS------GQVIAYLVLGVLL-F-IFSLV--YD-FFLFDKFNPEPD--------N-----ISY-R----------P-LLLRRLV-AKPAIIIVNMVTFLLCTGY-NGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVI-AAIASGVITK-K---------LGLV-KPLLIFGGVL-GVIGAGLM-----TLM----------------------------TN--T------STK--STQIGVLLLPGFSLGFALQ-ASLMSAQLQIT-KDRPEAAMDFIEVTAFNTFMKSLGTTLGGVLSTTV-F--SASF-HNK----VSR---------AHLEP----YEGKTVDDMILY-RLQNYD-------------GSHSTIGNILSDS-----IKNVFWMDLGFYALGFLF--CSFSSN---K---KL-----IIP-----------------------------------------------KKDETPEDNLEDK-------------------------------------------------------------------------------------- Pichia_stipitis_CBS_6054_pist_igi19987745 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NL--ASWITTSYLITSTAFQPLYGSFSDV-IGRRKCCFFASASFALGCLGCSMAT-----DIITFNLMRALTGIGGGGLITLSTIVNSDVITKR--KRGLFQAVQNLLLGFGA--VCGASFGGSIAS--Y--F---GWRW-CF---IFQVFPSIWSLIIGYKYI-------TNQ---------------------------------------------------PGFDESQQ---------------------------------------HLSSS------------------VL-----------ERI----DYKGSIILVSALTCQLFVLTLGG-------NEL----SWSD------SRLITLAILGATL-L-FYFIY--IE-L-------------------H-----TKA-N----------P-IIPVRRF-NSLFTVLLLAQNFLLGLCA-YAYLFALPLLFQIVLGDTPSKAGLRLAVPSLSTPI-GSVITGVMMN-K---------YGVL-KGLLYVGTMT-MAIGNFLT-----LLV----------------------------SP--S------TPS--WLLNILLMPANIGQGMAYP-SSLFTFIFAYG-TT------HQATSTSTIYLSRSIGGVFGVSSVSAI-I--QAYL-KFKVRKDLSA---------------LPELSHKEIHKIVIAISKSSDA-----------IYKYPDTIKSIILLD-YERAIRLAQLFSSICCATAFIL---CLMRD----------------------------------------------------------------ITRSKPDTSVA---------------------------------------------------------------------------------------- Pichia_stipitis_CBS_6054_pist_igi20837975 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDPRPAHYTSATHEVVVIALVCMGQFLSQVGVTMILSTMNILIHSFASNSSEIDQSK--TVWFMGSFALTVGTFILLSGRLGDL-FGLKLVFCIGWFWTAIWSLVCGLSVFSN--SVTFFIVSRAFQGIGFALVLPCGMGILGNTYPNGP-RKNLAFGCVGANGPTGA--TIGALMAAVIGQ--K--S---WWPW-EF---WILAIVSGLIGLLSVFMI-------PSN----------LN--------------------------------------------------------------------------------------PNKYT-------LRE--------AW-----------DKL----DVIGSLVGIVGLILFNFVWNQG--------PVV----GWST------PYIIALLIVSVLF-I-VLFFY--LQ-L-------------------N-----VLE-H----------P-LLPKSIF--TVKIGLVLAIVCLGWGSF-GVWQYYYWKIMLNLRQYTPIMTSLTYIPFLVFGIM-ASMIVSFIIS-----------RTKP-SYIICFSAIC-FTAGCLML-----SVT----------------------------PV--H------QSYF-QLTMGQMFILCWAMDMSFP-AASIILSDYLP-AS------SQGMAGSLVATVINYGVSLFLGISSTV-E--------------------------------------------------------------------IETSEHSTTLQS-----YRSALYFGTGVAVLGVVF--SVVFII------------------------------------------------------------------------------------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_S288C_sace0b09020g ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSI--SNWITTAYLITSTSFQPLYGSFSDA-LGRRNCLFFANGAFTIGCLACGFSK-----NIYMLSFMRALTGIGGGGLITLSTIVNSDVIPSS--KRGIFQAFQNLLLGFGA--ICGASFGGTIAS--S--I---GWRW-CF---LIQVPISVISSILMNYYV-------PNQ------------------------------------------------------KEYNRQNSS-----------------------------------IFQNP--------GK--------IL-----------RDI----DVMGSILIITGLTLQLLYLSLGCST-----SKL----SWTS------PSVLLLLVGSVII-L-LLFIL--HE-R-------------------K-----TSA-R----------A-IIPMELV-NSSYSVVVLSISILVGFAS-YAYLFTLPLFFQIVLGDSTAKAGLRLTIPSLFTPV-GSLITGFSMS-K---------YNCL-RLLLYIGISL-MFLGNFLF-----LFI----------------------------EK--T------SPN--WLIGLFLIPANLGQGITFP-TTLFTFIFMFS-KS------DQATATSTLYLFRSIGSVWGVAISAGV-I--QLSF-AGLLRSNLKG-----------------LLDENKIKKLIVQ-LSANSS------YIG----SLHGEVKNTVIKS-FDEATKRAHLMSTLLSSLALIL---CILKD-------NL-----AKP-----------------------------------------------KTRR----------------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_EC1118_sace_b_1b15_4786g ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSI--SNWITTAYLITSTSFQPLYGSFSDA-LGRRNCLFFANGAFTIGCLACGFSK-----NIYMLSFMRALTGIGGGGLITLSTIVNSDVIPSS--KRGTFQAFQNLLLGFGA--ICGASFGGTIAS--S--I---GWRW-CF---LIQVPISVISSILMNYYV-------PNQ------------------------------------------------------KEYNRQNSS-----------------------------------IFQNP--------GK--------IL-----------RDI----DVMGSILIITGLTLQLLYLSLGCST-----SKL----SWTS------PSVLLLLVGSVII-L-LLFIL--HE-R-------------------K-----TSA-R----------A-IIPMELV-NSSYSVVVLSISILVGFAS-YAYLFTLPLFFQIVLGDSTAKAGLRLTIPSLFTPV-GSLITGFSMS-K---------YNCL-RLLLYIGISL-MFLGNFLF-----LFI----------------------------EK--T------SPN--WLIGLFLIPANLGQGITFP-TTLFTFIFMFS-KS------DQATATSTLYLFRSIGSVWGVAISAGV-I--QLSF-AGLLRSNLKG-----------------LLDENKIKKLIVQ-LSANSS------YIG----SLHGEVKNTVIKS-FDEATKRAHLMSTLLSLLALIL---CILKD-------NL-----AKP-----------------------------------------------KTRR----------------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_JAY291_sace_c_01581 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSI--SNWITTAYLITSTSFQPLYGSFSDA-LGRRNCLFFANGAFTIGCLACGFSK-----NIYMLSFMRALTGIGGGGLITLSTIVNSDVIPSS--KRGIFQAFQNLLLGFGA--ICGASFGGTIAS--S--I---GWRW-CF---LIQVPISVISSILMNYCV-------PNQ------------------------------------------------------KEYNRQNSS-----------------------------------IFQNP--------GK--------IL-----------RDI----DVMGSILIITGLTLQLLYLSLGCST-----SKL----SWTS------PSVLLLLVGSVII-L-LLFIL--HE-R-------------------K-----TSA-R----------A-IIPMELV-NSSYSVVVLSISILVGFAS-YAYLFTLPLFFQIVLGDSTAKAGLRLTIPSLFTPV-GSLITGFSMS-K---------YNCL-RLLLYIGISL-MFLGNFLF-----LFI----------------------------EK--T------SPN--WLIGLFLIPANLGQGITFP-TTLFTFIFMFS-KS------DQATATSTLYLFRSIGSVWGVAISAGV-I--QLSF-AGLLRSNLKG-----------------LLDENKIKKLIVQ-LSANSS------YIG----SLHGEVKNTVIKS-FDEATKRAHLMSTLLSLLALIL---CILKD-------NL-----AKP-----------------------------------------------KTRR----------------------------------------------------------------------------------------------- 'Saccharomyces cerevisiae RM11-1A sace d 02679' ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSI--SNWITTAYLITSTSFQPLYGSFSDA-LGRRNCLFFANGAFTIGCLACGFSK-----NIYMLSFMRALTGIGGGGLITLSTIVNSDVIPSS--KRGTFQAFQNLLLGFGA--ICGASFGGTIAS--S--I---GWRW-CF---LIQVPISVISSILMNYYV-------PNQ----------KE----------------------------------------YNRQNSS---------------------------------------IFQNP--------GK--------IL-----------RDI----DVMGSILIITGLTLQLLYLSLGCS-----TSKL----SWTS------PSVLLLLVGSVII-L-LLFIL--HE-R-------------------K-----TSA-R----------A-IIPMELV-NSSYSVVVLSISILVGFAS-YAYLFTLPLFFQIVLGDSTAKAGLRLTIPSLFTPV-GSLITGFSMS-K---------YNCL-RLLLYIGISL-MFLGNFLF-----LFI----------------------------EK--T------SPN--WLIGLFLIPANLGQGITFP-TTLFTFIFMFS-KS------DQATATSTLYLFRSIGSIWGVAISAGV-I--QLSF-AGLLRSNLKG-----------------LLDENKIKKLIVQ-LSANSS------YIG----SLHGEVKNTVIKS-FDEATKRAHLMSTLLSLLALIL---CILKD-------NL-----AKP-----------------------------------------------KTRR----------------------------------------------------------------------------------------------- 'Saccharomyces paradoxus NRRL Y-17217 sapa c84 2183' --------------------------------------------------------------------------------------------------------------------------------MSSGVISSSNDKKCETRQFYEVTEREKHTNDDTYS----------------------------------------------------------------------------------------------------ITSTFFKLKENEIISAQFDSLKYKILLIITSFLCGIGLSLDYTLRSTYTGYATNSYS------EHSL--LSTVQVVNDVVSVGSQVVFSRLSDY-FGRLKLFSIATIFHIMGTIIQSQAT-----SLTMYAIGSVFYNCGYVGVNLLLILILSDFSSLK--WRMFYQYTSYWPYIIIP-WISGSIITAANPE--K------NWSW-NIAMWAFIYPLSALPIMFLILYM-------TYK----------SS-------------------------------------KTPELRSLKEQARKEKISG------------------------------LFRNL--------MF--------LF-----------WKL----DVVGIVLITVSLGCVLVPLTLANE------VSQ----KWQN------PKIIGTLVVGGCL-F-VIFVF--WE-A-------------------K-----FAR-A----------P-LLPFKLL-SDRGIWAPLGVTFFNFFTF-FISCDYLYPVLLVSMKESSTSAARIVNMPDFVAAT-ASPFYSLLVA-K---------TRKL-KLSVIGGCAA-WMVCMGLF----YQYR----------------------------GG--T------GSH--GGVIAASIIMGLSGLLCSN-SVIVILQAMTT-HN------RMAVVTGIQYT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Candida_lusitaniae_ATCC_42720_calu_03396 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDSRPKILKSPLQELVLLGTVCLGQFLSQGSISMSLSTMNIIQEYFEEKGSG-SNSQ--KVWYMGSYALTLGSFILVSGRLGDL-FGLRKIFVFGWFWAALWSLVTGLSYFSE--SSILFIICRAFQGIGFALIIPCGVGILGTTYPNGK-RKNFAFAFFASAAPVGA--SLSCLMSGMLAQ--L--A---RWDW-AF---YCLAIACAILGSLSIYAI-------PGP---------FRH--------------------------------------------------------------------------------------HNYTL--------KE--------AF-----------ARF----DTWGALLGVAGLVILNFVWNHG--------PVV----GWST------PYIIVLLVLSVVL-L-ASFFS--YE-L-------------------L-----FAS-V----------P-LLPRSVF--NLRIGLVLACMSLGWGSF-GVWQYYYWSFMMGFRHYTPVETALTYMPLLILGVV-AALIVGHFMS------------KRT-APYIIFASMC-GFLGGCLF----LEFL----------------------------PV--H------QSFW-HLSFAQMFLLPWGMDCSFP-AASLILSDFLP-EE------HQGMAGSLVNTVVNYSVSFFLAVASTV----EIEV------------------------------------------HKRNND---------------------------VLSSYRSAVYLGVGIAGLAVLVAVVFIFVE----------------------------------------------------------------HGEHKKIEESD---------------------------------------------------------------------------------------- Pichia_stipitis_CBS_6054_pist_igi20835632 ---------------------------------------------------------------------------------------------------------------------------------------------------------MLAEPNYQDI-----------------------------------------------------------------------------------------------------------------------SLSREIGFMVLMCLSQLLTQAAVSQTMISADYIAPTFGVSG---SPGE--ISWFSASFSLTVGTFILISGRLGDM-YGYKLLYIVGYIWFAVFSLATGFAGFGS--SSVLFNVMRALQGIGPAIMMPNSQALISSFYPNT-FRKSICMCLFGAVAPSGF--TLGAFFSAIFAQ--F--S---WWPW-TF---WVCGIVSFFVAICAYFVI-------PNK----------IG--------------------------------------------------------------------------------------TRSSV------------------SF------------------DFYGSTAGVAGMVLINFAWNQG--------PVV----GWDK------PYVYSMLIVGIFC-I-IGFLF--IE---------------------K-----KVK-D----------P-LISQEVL--KGETGAVLCCIAAGWSTF-GIWLFYYFRWSMLVDGDTPILSVTKSLVVIFPGFI-AALSTGYLVH-----------RIPS-SFILLIAMLA-FFTGIVLM-----GTR----------------------------PV---------GQIYWSQKFVSLIIEPFGMDMSFP-AACIILSGALP-AA------QQGMAGSLVSTFVNYSISIGLGIAGTVEY------------------------------------------------YVTKNM--------------------EPSLDT-TVYGMRRAFQMGYGLAGLGVLIACSFVYIQ-------LV-------------------------------------------------------QRRKEANQESVGKNSLG---------------------------------------------------------------------------------- 'Candida tropicalis MYA-3404 catr 02586' ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKVSSFDPRPEIFKSQFHEIIVVGLICLAQLLTQGGITMSLSSMNIILKSFNS----IDSTK--QVWFMGSYALTVGTFILISGKLGDI-FGLKLIFVIGWIWITIFSIITGISNYV---SIEFFIICRALQGIGFALLIPCGMGILGHIYPNGK-RKNFAFGCVGANGPIGA--YIGAIMSAVISQ--L--W---WWPW-NF---WILSIVSAVLTVASWVFI-------PNV--------------------------------------------------------------------------------------------------NIRDT--------VD--------LF-----------NKL----DPWGCLTGVSGLILLNFVWNQG--------PIQ----GWNT------VYVIVLLIVAVLF-I-IAFFL--LE-L-------------------H-----VSK-Y----------P-LIPKPIF--NIKIGMILACISCGWGSF-GVWQYYYWNIIMNLRQYTPIEGGLTYTPFLVLGVI-ASLFVSYVIS-----------HTKP-SYIICFATIC-FMIGDLML-----AVT----------------------------PI--K------QSFF-RLTFGQMFILCWGMDMSFP-AASIILSDILP-NH------HQGMAGSLVSTMINYSVSLFLAMSSCV----EIEI------------------------------------------MKRTND---------------------------QLLSYRSGLYFGIGVACLGVLCSVIFIFIQ-------KD-------------------------------------------------------DGAGTNDLIKQQEFIDSSKESL----------------------------------------------------------------------------- Pichia_stipitis_CBS_6054_pist_igi19138887 -----------------------------------------------------------------------------------------------------------------------------------------------------MKVFTNPVPNYQDI-----------------------------------------------------------------------------------------------------------------------SIFRECFFISLLCMTQLLTQAAVSQTVNNSEYVARTFGVQD---KPGE--ISWFTASYSLTVGTFILIFGRLGDM-HGYKLMFVLGYLWFGIFSSATGFAGFSS--STILFDIMRALQGIGPAILMPNSVALIGSYYPPG-FRKNLCMCLFGSVAPTGF--ILGAFFNGIFAQ--L--V---WWPW-TF---WVCGMVCFVIAVAGFFVI-------PKG--------------------------------------------------------------------------------------------------VGILA--------KG--------SF------------------DYFGSAAGVTGLILFNFAWNQG--------PVA----GWER------PYVYVLMIVGLIS-I-ALFFY--IE---------------------K-----SVI-D----------P-LVPRSV--LKGETGAVLGCIAAGWSCF-GIWLFYMYRWSLVIDGDTPILAATKNLPCIIPGFL-AAISAAFLVQ-R----------FPT-SFVLFLSMLA-FFVGIVLM-----GTR----------------------------PV--G------QIFW-AQKFVSLLIQPIGMDMSFP-AACIILSSALP-PA------QQGIAASLVATVVNYSISIGLGFAGTV-E-----------------------------------------YYKTKD-MSPSFE--------T------------------TVHGIRVAFYMGFGLAGLGVLV--SALFMF---Q---QI------IN------KK------------------------KRSP-----------SADEEKSTRAPSV-------------------------------------------------------------------------------------- Kluyveromyces_lactis_CLIB210_klla0b00352g --------------------------------------------------------------------------------------------------------------------------------------------------------------MSSKK----------------------------------------------------------------------------------------------------LNSHEEQDSLLLQNSREWTSLLKEGFAIMVLCSAQLMTQAGLAQSIVPLQIIGDSFGIK----NPGQ--LSWFASAFSLTVGTFILIAGRLGDT-FGHKKFFVMGFLWYALWSILAGFSVYS---NQIFFDCCRAFQGIGPAFTLPNAIAIIARTYRPG-RKQNMIFSLFGACAPSGF--VVGAVFSSLLSE--F--A---WWPW-AY---WIMGITCFLLGVAGYLVI-------PHH--------------------------------------------------------------------------------------------------PPIHP--------DE-----KCSLV-----------ERI----DVAGSVTGVVGLILFNFAWNQG--------PVV----GWET------SYTYALLIVGSAF-L-AAFGF--IE---------------------S-----RAK-H----------P-LLPVRKL--SSDTIFVMGCIAAGWSSF-GIWVYYTWQLMANLRDQPPLLSSAQFVPVAISGLC-AAMSTEFLLT-----------RTSP-STVMIIAMIA-FTVGSILV-----ATV----------------------------PV--S------QTYW-AQTFVSIIVMPWGMDMSFP-AATIILSTAMP-AS------HQGLAASLVNTIINYSISIGLGFAGTI----ESQI------------------------------------------SDGEDD---------------------------LLKGYRGAYYMGIGLAGLGLGV--AISYAI---FHYSRL-----KRS-----------------------------------------------LSEKYV--------------------------------------------------------------------------------------------- 'Saccharomyces bayanus 623-6C saba a 556.17' -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNRVAEEFS------ESSK--KQWIATSFLLTNTAFQPLYGKLSDI-IGRRPALLTAQFFFGLGCLMTCFAR-----NVTEFSIARAVCGIGAGGLNAISSIAVSDICTAR--ERGVYQGYANIVFGFGQ--LLGAPLGGIFIE--T--I---GWRA-LF---GVQVPMIIVCSILAIKNI--NIKLFHVP----------PM--------------------------------------------------------------------------------------KERYT--------LK--------NL-----------SRI----DIFGSLSLVATISGVLFLCS-----------------SHMN------KIYLALFTIGS---F-IVFVL--VE-R-------------------Y-----YAT-E----------R-ILPFELL--TGSFCLSSAVTVISSFVV-FGEIFRSPIYLQLLQNISVTKTGLFLIFPSISVAV-GSLVTGWVLR-N-----TKMNLAHC-AYQIIFGGMVTQLLGLGMG-----YLLLGHLYPDYTVY-----------------DMLESITFKSHSIWWKLIYVFASVLVSFGYACLLV-ATLVSIVFTVE-KS------QQGTMTGVFYLWRSIGNVLGASLTLVS-Y--ENSL-SSM----LWS-----YMFERKRDD------GYHFTKKQYYSLINDSS------YLR--KPNFPTDIFVRILDV-YKKAFLISYLPNIALAVVGIVL--SLYLVK---H---TL-----KRS------ST------------------------------------------------------------------------------------------------------------------------------------------ Candida_albicans_SC5314_caal_a_19.304 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVSLDPRPTIFTSSHHEIIVVTLICLAQFFTQAGITLSLSTMNIILKSFDT-I---NSAK--QVWFMGSYALTVGTFILISGKLGDL-LGLKLIFVIGWIWTTVFSAITGLSNYV---SVEFFIICRALQGIGFALLIPCGMGILGNIYPNGE-RKNLVFGCVGANGPAGA--FFGAFIAALIAQ--L--W---WWPW-IF---WLLSIGCVVLTIISMIYI-------PPI---------THH--------------------------------------------------------------------------------------KLESY--------SE--------FF-----------KRI----DPLGTLTGIIGLILFNFVWTQG--------PVV----GWNT------AYIIALLIIAVLS-I-VAFFI--IE-L-------------------Y-----IAK-Y----------P-LVPKSVF--NLKIGMVLACISCGWGSF-GIWQYYYWNIILNLRKYTPIAGSLTYVPFLVMGII-AAIASSIIIS-----------HTKP-SYIISFSTIC-FMVGCLML-----SVT----------------------------PI--Q------QSYF-RLTLGQMFILCWAMDMSFP-AASIILSDYLP-NH------HQGMAGSLVSTVINYSVSLFLGMSSCV----ETEI------------------------------------------KLSTHN---------------------------VLLSYRSGLYFGIGVASLGIFCSLIFIFVQ---R----------NDG-----------------------------------------------KGTNALLVDSEEEIIRESTEDVMEKK------------------------------------------------------------------------- 'Candida albicans WO-1 caal b 02627' -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVSLDPRPTIFTSSHHEIIVVTLICLAQFFTQAGITLSLSTMNIILKSFD------TIDSAKQVWFMGSYALTVGTFILISGKLGDL-LGLKLIFVIGWIWTTVFSAITGLSNYV---SVEFFIICRALQGIGFALLIPCGMGILGNIYPNGE-RKNLVFGCVGANGPAGA--FFGAFIAALIAQ--L--W---WWPW-IF---WLLSIGCVVLTIISIIYI-------PPI--------------------------------------------------------------------------------------------------THHKL-----ESYSE--------FF-----------KRI----DPLGTLTGIIGLILFNFVWTQG--------PVV----GWNT------AYIIALLIIAVLS-I-VAFFI--IE-L-------------------Y-----IAE-Y----------P-LVPKSVF--NLKIGMVLACISCGWGSF-GIWQYYYWNIILNLRKYTPIAGSLTYVPFLVMGII-AAIASSIIIS-----------HTKP-SYIISFSTIC-FMVGCLML-----SVT----------------------------PI--Q------QSYF-RLTLGQMFILCWAMDMSFP-AASIILSDYLP-NH------HQGMAGSLVSTVINYSVSLFLGMSSCV----ETEI------------------------------------------KLSTHN---------------------------VLLSYRSGLYFGIGVASLGIFCSLIFIFVQ---R----------NDG-----------------------------------------------KGTNALLVDSEEEIIRESTEDVMEKK------------------------------------------------------------------------- Candida_dubliniensis_CD36_cadu_83050 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVISLDPRPKIFTSRYHEIIVVTLICLAQFFTQAGITLSLSTMNIILNSFNT-I---DSAK--QVWFMGSYALTVGTFILISGKLGDL-LGLKLIFVIGWIWTTVFSTITGLSNYV---SVEFFIICRALQGIGFALLLPCGMGILGNIYPNGE-RKNLVFGCVGANGPSGA--FFGAFIAALIAQ--L--W---WWPW-IF---WLLSIGGAMLTIISIIYI-------PPI--------------------------------------------------------------------------------------------------PHHKF-----ESYSE--------FF-----------KRI----DPLGTSTGIVGLILFNFVWTQG--------PVV----GWNT------AYIIVLLIIAVLS-I-VAFFI--VE-L-------------------F-----IAE-Y----------P-LVPKSVF--NLKIGMVLACISCGWGSF-GIWQYYYWNIILNLRKYTAIAGSLTYVPFLVMGII-AAIASSIIIS-----------HTKP-SYIISFATIC-FMVGCLML-----SVT----------------------------PI--Q------QSYF-RLTMGQMFILCWAMDMSFP-AASIILSDYLP-SH------HQGMAGSLVSTVINYSVSLFLGMSSCV----ETEI------------------------------------------KLRTHN---------------------------VLLSYRSGLYFGIGVASLGIFCSLIFIFIQ---R----------NDG-----------------------------------------------KGTNALLVDSEEEIIRDSTEDIIEKK------------------------------------------------------------------------- Debaryomyces_hansenii_CBS767_deha2d11572g ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDPRPIYFKTTLHEILFVFVICMAQLLAQGGITMSLTPMNIILDSFAENSDSIEGSE--RVWFMGSFALTVGTFILISGRLGDL-FGLKQMLLVGWAWVVVWAIVTGLSYYSH--SIIFFIICRAFQGIGFALILPCALGILGNIYPIGD-RKNLAFGCVGASGPVGA--TFGAIFAAILAE--L--A---WWPW-VF---WILAIVACLLGITSFFII-------PNN-----------------------------------------------------ISNVN----------------------------------------SELDT--------RE--------KL-----------KRM----DILGSTFGIVSLVIFNFVWNQG--------PVE----GWDT------PYIIVLLIISSIG-I-ISFFY--IE-L-------------------K-----VAE-Y----------P-LLPKSIF--NFKIGLLLLCISFGWGSF-GIWQYYYWSIVLNLRQYTPIAAGLTYIPFFVLGII-AALSVSVLIS-----------KIKP-SYIICFASVS-FMCGCIML-----SIM----------------------------PV--D------QSYF-QISMGQMFLLAWGMDLSYP-AAALILSDFLP-LH------HQGMAGSLVSTVVNYSVSLFLGIASTV-E--------------IQT-------------------------------MQHHHN---------------------------TLKSYRAAIYMGIGVAFLGVLFAIIFIVAQ---H---TK-----NDP-----------------------------------------------DPEITVVKEPSITDVDSKEIKVPLDI------------------------------------------------------------------------- 'Kluyveromyces waltii NCYC2644 klwa 034-snap.4' ----------------------------------------------------------------------------------------------------------------------------------------------------MDAELESLEAQFVEL----------------------------------------------------------------------------------------------------KNEEGESLQLVQSHVEKPQSLMREALFVGILSCAQLMTQAGLAQSIAPVRIIGNSFGIS----NPGQ--LSWFSAAYSLTVGTFILIAGRLGDL-FGHKKLFVVGFLWYSLWSLLAGFSVYS---NQIFFDCCRALQGIGPAFLLPNSIAILGRTYTPG-KRKQMVFSIFGATAPGGF--VLGSVFSSIFSQ--L--A---WWPW-AY---WAMGTACLVLGVAGIIVI--------PQ---------APP--------------------------------------------------------------------------------------PKIDI---------S------AGIL-----------ERI----DAAGATTGILGLALVNFAWNQG--------PVV----GWQT------PYTYALLIVGFVF-L-LVFSL--IE---------------------S-----RAR-F----------P-LLPFAAL--STDLAYVLGCIAAGWSSF-GIWIFYFWQFLEDSRSQSPLLTSAQFVPVAISGLC-AALTTGYILS-----------HVPA-CAVMLIAMIA-FTVGGVLV-----ATA----------------------------PI--N------QTYW-AQTFVSLIIMPWGMDMSFP-AATIMISNAMP-HE------HQGLAASLVNTVVNYSISLALGFAGTI-E-------TRV--------------------------------------NNKGAN---------------------------RLEGYRGAWYMGIGLSGLGVLV--AIVYAW---S---TL-----KKF-----------------------------------------------KEEQLSEKSSNN--------------------------------------------------------------------------------------- Candida_guilliermondii_ATCC_6260_cagu_00085 ---------------------------------------------------------------------------------------------------------------------------------MVTFLNWKKIVM--------SNISNMNTDVSDPE----------------------------------------------------------------------------------------------------TVTGNEDKTNTIEIIEPQISLFHEILFVLIIFSGQFVTQVSVAQGLSSIRIIGEWFN------ITNEAELTWSIASLSLSAGTLIIIAGRLGDI-LGHKRMFLFGYVWLTIWSLLTGASSYS---NAVFYYCCKGFQGVGPAFLLPNGLAILGRFYPPG-KRKTIAFVVFGAGTPLGF--VFGSIFGAIFSQ--F--T---HWAW-IY---WSMGIACACLTILAFLII-------PQD--------------------------------------------------------------------------------------------------TLDEG--------RN---------------------KEF----DFLGAFTGVGGLVLFNVAWNQA--------PIV----KWST------PYTYILLVIGVLL-L-SIFVY--VE-L-------------------K-----VSQ------------P-LIPIKQM--SPIVLRVLICVACGFGTF-GILIYFYFNFLLSLRGDSPILAAVKFTPAIVSGLL-AAAFTGFMLS-----------KGVTTQVLMVIGLLA-FVISAAML-----SVV----------------------------DV--H------DSYW-ASCFITFIIAPFGVDVCFP-AATLLLSDVVP-HE------WQGISASLVATVVNYSISLALGVAGTA-V--------------LKQ---------------------------------APGT-------------DFNAEVKATKTAA-YVGC--ALSAVGSLVAIYGVIV--DHFKRN--------------RKS-------------------------------------------------------------------------------------------------------------------------------------------------- Candida_guilliermondii_ATCC_6260_cagu_05158 --------------------------------------------------------------------------------------------------------------------------------------------MSMRSASTTCEATICDEPQIVVV----------------------------------------------------------------------------------------------------KEENEENAHTNAVPSCVEIRFFHEIAFVFCMCCGQLHAQAAVAQAMAATQEIAKSFGV-----ENSPGEQAWFSASFSSTVGTFILVSGKLGDM-FGYKLMYITGLLFFALWSLICGFSAYAK--SAVFFDVCRALQGAGSALLLPNAVAVLGHYYPPGSMRKTIVMCLFGAAAPSGF--NIGALFSSFFAM--K--V---WWPW-TF---WVCGIASVCLALLSYLCI-------PKK--------------------------------------------------------------------------------------------------IGTPS--------RN---------------------EPF----DWIGSILAISGLILFNFAWNQG--------SNV----GWKI------VYNYVLLIVSVGL-V-VAFAI--VE-V-------------------------YLK-H----------P-LVPIKSLKGEPAFVLGCIAT--GWSCF-GIWLYYTFQWAFYIDNVNAVVASVQFIPCSVTGFM-ASFTTAYLLR-----------RTRS-SFVMIMAMCA-FFAGIIII-----GTR----------------------------HV--G------QTYW-GQKFVSCLIQPFGMDMSFP-AAIIILSNHFP-PS------KQGIAASLVATVQNYSVSLGLGFAGTV--------------------------------------------------------------------EKYKTDHLPQTFES-KLLGIRVAFYMGMGLAGLGVVF--SVIGGI-------LQ-------------------------------------------------------WKRTKKDQE------------------------------------------------------------------------------------------ Kluyveromyces_thermotolerans_CBS6340_klth0c10560g ----------------------------------------------------------------------------------------------------------------------------------------------MSFTDKEENQKKDDGLTREST----------------------------------------------------------------------------------------------------HDQGQELSQPHHNGIQKPESLLGEAAFVGVICGAQLMTQAGLGQSIAPLHIIGDSFG------TRNPGQLSWFAAAYSLTVGTFILIAGRLGDV-YGHKKFFIIGFFWYALWSLLAGFSVYS---NQIFFDCCRAFQGIGPALLLPNAIAILGRTYVPG-RRKAMILSLFGATAPAGF--VLGAVFSSIFGQ--L--T---WWPW-AY---WAMGIVCFFLAVAGILVI--------PR---------MPL--------------------------------------------------------------------------------------PELDT---------S------VSTY-----------QRL----DIPGSVTGVIGLVLLNFAWNQG--------PVV----GWQT------PYTYSLLIVSAVF-L-CVFAF--IE---------------------S-----RAP-H----------P-LLPLSAL--SSDAAFVLGCVGAGWSSF-GIWIYYFWLFLEELRGHSPLLTSAQFAPVAISGLC-AALTTGFVIT-----------RVRA-SLVMLFAMTA-FTVGGILI-----ATA----------------------------PV--K------QVYW-AQAFVSIIVMPWGMDMSFP-AATIMLSDSMP-HE------HQGLAASLVNVVVNYSISIGLGLAGTV-E-------GRV--------------------------------------NNGGAN---------------------------LLKGYRGAWYMGIGLSGFGILI--AFMYEY---H---TF-------------------------------------------------------KKSKKMPSEKPFA-------------------------------------------------------------------------------------- 'Kluyveromyces waltii NCYC2644 klwa 042-snap.2' ---------------------------------------------------------------------------------------------------------------------------------MNMKENDDEENW--------EKLQSSSAAGEERD----------------------------------------------------------------------------------------------------GQTEAIGPKSRLQNPDYFDKPWKEYIFVLSSMLSQLLNQAATTQTNPLFDVLSKDLNA-----KVSQ--QPWLMASFPLVSGSFILVSGKVGDI-YGLKKTLLGGYVVVVIWSLICGLSSYAH--NVDFFVVARSFQGLGIAFVLPNVMGIVGNIYKPNTEAKNLVFSLIGACAPIGA--TLGCVFSGLIGA--R--T-D-LWGW-TF---YAYAITAALNGLVALWII-------PNN--------------------------------------------------------------------------------------------------IPTNV--------NE---------------------YKM----DWIGSAIGVFGLILFNFVWNQA--------PIA----GWGS------AYIIVLLIVAVVA-L-IAFIT--YE-I-------------------R-----FAK-Q----------P-LLPHSVL-FNRKLMMILSSLFFGWGSF-GIWTFYYMSFMLNLRHYSPLWAGGTYFMFAIWGIV-ASLLVGYTIH-K---------TGPA--VILFLSMVA-FDCGCIML-----AVT----------------------------PV--H------QTYF-RMTLGIMIILSFGMDLSFP-AASIILSDQLP-SQ------YQGMAGSLVSTMISYSMSLCLGISGTA-E--HQVN-------------------------------------------KNGID---------------------------LLKGYQAALYVGIGLASLGVVI-SGAFMIE-------DW-------------------------------------------------------WTSRRKRTT------------------------------------------------------------------------------------------ 'Kluyveromyces waltii NCYC2644 klwa 116-snap.16' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTGYNLPNALCMLLWGRIASL-VGLKNSLVASIVIFEAGSLLAALAT-----SMGMLIGGRVIAGFGGSGIETLVFAVGTRMVDEK--HRARVVTILGIAYMLAE--GAGPFIGGAFAE--H--V---SWRW-CF---FINIPIGGVALAILCWGY-------NPA----------GR--------------------------------TPINALNHYWKSYRKCS-------------------------------------WKKVF------------------RLTSLTKVVKLFIYQL----DIVGLLLSSGGFALIMLALTFGG-------NKF----AWNS------ASIICMFTIGIAL-L-GIFML--YD-FVVLPYIGRRLE--------N-----GEA-M----------P-LVPWSLA-CNMPILTSSMAGFFNSFAF-ELQSIYLVQYYQLVTNEGPVFASIHLWQMSVPALI-TVIVSAAINE-K---------FGIV-KPIIVTGVVF-GFIGSGLL-----TLF----------------------------GS--N------TST--GASIGYSMLAGASFGCVYQ-LSLLSSQLEVR-KDDPEYHKNFIEVTAYNTFIKTMGFSFAGILSTTI-F--SVSL-KNLASSHVGL------------------PHFSTVEDIMDY-RSQHYD-------------GRNSPLGKIMAQS-----IRNVFYCALACSALSFIF--GIFTSS---K---RT-----ATS-----------------------------------------------RDEQMQEMSENESLTPESKKEGII--------------------------------------------------------------------------- 'Saccharomyces bayanus 623-6C saba a 673.19' ------------------------------------------------------------------------------------------------------------------------------------------------MPRRPSVTQKNLETSAETT----------------------------------------------------------------------------------------------------KTDDEVLLNQFELQDETPGSLVWEAAFVGVLCSAQLMTQAGLGQSIAPLHIIGDSFG------TTNPGQLSWFASSYSLTVGTFILIAGRLGDI-FGHRKFFILGFFWYALWSLLAGFSVYS---NKIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPG-KRKNMVFSLFGASAPGGF--VLGAVFSSMLGQ--L--A---WWPW-AY---WIMGIACFLLAVAGYFVI-------PHV----------QM--------------------------------------------------------------------------------------PSRDS------PSFN--------ML-----------ERV----DFAGSVTGVIGLILFNFAWNQG--------PVV----GWET------PYTYVLLIVGTVF-L-GVFVF--IE---------------------S-----RAA-Y----------P-LLPFAAL--SSDAAFVLGCIAAGWSSF-GIWIFYTWQFMEESRKQSPLLSSAQFAPVAISGFC-AAVTTGFLLS-----------HTPA-STVMLFAMTA-FTVGIILI-----ATA----------------------------PV--H------QTYW-AQTFVSIIVMPWGMDMSFP-AATIMLSNSMP-HE------HQGLAASLVNTVVNYSISIGLGIAGTI----ESQV------------------------------------------NDGGAN---------------------------ALKGYRCSWYMGIGLSGLGIFV-AAVYASS-------TF---------------------------------------------------------LKSKKKASEKQYIE----------------------------------------------------------------------------------- Saccharomyces_bayanus_MCYC_623_saba_b_c773_24081 ------------------------------------------------------------------------------------------------------------------------------------------------MPRRPSVTQKNLETSAETT----------------------------------------------------------------------------------------------------KTDDEVLLNQFELQDETPGSLVWEAAFVGVLCSAQLMTQAGLGQSIAPLHIIGDSFG------TTNPGQLSWFASSYSLTVGTFILIAGRLGDI-FGHRKFFILGFFWYALWSLLAGFSVYS---NKIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPG-KRKNMVFSLFGASAPGGF--VLGAVFSSMLGQ--L--A---WWPW-AY---WIMGIACFLLAVAGYFVI-------PHV----------QM--------------------------------------------------------------------------------------PSRDS------PSFN--------ML-----------ERV----DFAGSVTGVIGLILFNFAWNQG--------PVV----GWET------PYTYVLLIVGTVF-L-GVFVF--IE---------------------S-----RAA-Y----------P-LLPFAAL--SSDAAFVLGCIAAGWSSF-GIWIFYTWQFMEESRKQSPLLSSAQFAPVAISGFC-AAVTTGFLLS-----------HTPA-STVMLFAMTA-FTVGIILI-----ATA----------------------------PV--H------QTYW-AQTFVSIIVMPWGMDMSFP-AATIMLSNSMP-HE------HQGLAASLVNTVVNYSISIGLGIAGTI----ESQV------------------------------------------NDGGAN---------------------------ALKGYRCSWYMGIGLSGLGIFV-AAVYASS-------TF-----LKS-----------------------------------------------KKKASEKQYIE---------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_S288C_sace0o12012g -------------------------------------------------------------------------------------------------------------------------------------------------MSTSSSVTQKNLDTNAEA----------------------------------------------------------------------------------------------------LKKEDKVLSEFDIQDERPKSLLWESAFVGVLCSAQLMTQAGLGQSLAPLHIIGNSFG------TTNAGQLSWFASAYSLTVGTFILIAGRLGDI-FGHKKFFVLGFFWYALWSLLAGFSVYS---NQIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPG-RRKNMVFSLFGASAPGGF--FLGAVFSSMLGQ--L--A---WWPW-AY---WIMGIACFVLAVAGYFVI--------PH---------TPM--------------------------------------------------------------------------------------PSRDA--------SS------FKLL-----------ERI----DFAGSVTGVVGLILFNFAWNQG--------PVV----GWQT------PYTYALLIVGTFF-L-VIFAY--IE---------------------S-----RAA-F----------P-LLPFAALSSDTAFVLSCIAA--GWASF-GIWIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFC-AAVTTGFLLS-----------HTPP-STVMLFAMTA-FTVGTILI-----ATA----------------------------PV--H------QTYW-AQTFVSIIVMPWGMDMSFP-AATIMLSDSMP-HE------HQGLAASLVNTVVNYSISIGLGIAGTI----ESRV------------------------------------------NDGGAK---------------------------PLKGYRCSWYMGIGLSGLGIFVAATYAWST-------FM-------------------------------------------------------KSKKRISEKQHFIE------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_JAY291_sace_c_04464 -------------------------------------------------------------------------------------------------------------------------------------------------MSTSSSVTQKNLDTNAEA----------------------------------------------------------------------------------------------------LKKEDKVLSEFDIQDERPKSLLWESAFVGVLCSAQLMTQAGLGQSLAPLHIIGNSFG------TTNAGQLSWFASAYSLTVGTFILIAGRLGDI-FGHKKFFVLGFFWYALWSLLAGFSVYS---NQIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPG-RRKNMVFSLFGASAPGGF--FLGAVFSSMLGQ--L--A---WWPW-AY---WIMGIACFVLAVAGYFVI--------PH---------TPM--------------------------------------------------------------------------------------PSRDA--------SS------FKLL-----------ERI----DFAGSVTGVVGLILFNFAWNQG--------PVV----GWQT------PYTYALLIVGTFF-L-VIFAY--IE---------------------S-----RAA-F----------P-LLPFAAL--SSDTAFVLSCIAAGWASF-GIWIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFC-AAVTTGFLLS-----------HTPP-STVMLFAMTA-FTVGTILI-----ATA----------------------------PV--H------QTYW-AQTFVSIIVMPWGMDMSFP-AATIMLSDSMP-HE------HQGLAASLVNTVVNYSISIGLGIAGTI-E--SRVN-------------------------------------------DGGAK---------------------------PLKGYRCSWYMGIGLSGLGIFV--AATYAW---S---TF-----MKS------KK---------------------------------------RISEKQHFIE----------------------------------------------------------------------------------------- 'Saccharomyces cerevisiae RM11-1A sace d 01751' -------------------------------------------------------------------------------------------------------------------------------------------------MSTSSSVTQKNLDTNAEA----------------------------------------------------------------------------------------------------LKKEDKVLSEFDIQDERPKSLLWESAFVGVLCSAQLMTQAGLGQSLPPLHIIGNSFG------TTNAGQLSWFASAYSLTVGTFILIAGRLGDI-FGHKKFFVLGFFWYALWSLLAGFSVYS---NQIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPG-RRKNMVFSLFGASAPGGF--FLGAVFSSMLGQ--L--A---WWPW-AY---WIMGIACFVLAVAGYFVI--------PH---------TPM--------------------------------------------------------------------------------------PSRDA--------SS------FKLL-----------ERI----DFAGSVTGVVGLILFNFAWNQG--------PVV----GWQT------PYTYALLIVGTFF-L-VIFAY--IE---------------------S-----RAA-F----------P-LLPFAALSSDTAFVLSCIAA--GWASF-GIWIFYIWQFMEDSRGQTPLLSSAQFSPVAISGFC-AAVTTGFLLS-----------HTPP-STVMLFAMTA-FTVGTILI-----ATA----------------------------PV--H------QTYW-AQTFVSIIVMPWGMDMSFP-AATIMLSDSMP-HE------HQGLAASLVNTVVNYSISIGLGIAGTI----ESRV------------------------------------------NDGGAK---------------------------PLKGYRCSWYMGIGLSGLGIFVAATYAWST-------FM-------------------------------------------------------KSKKRISEKQHFIE------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_YJM789_sace_e_5421 -------------------------------------------------------------------------------------------------------------------------------------------------MSISSSVTQKNLDTNAEA----------------------------------------------------------------------------------------------------LKKEDKVLSEFDIQDERPKSLLWESAFVGVLCSAQLMTQAGLGQSLAPLHIIGNSFG------TTNAGQLSWFASAYSLTVGTFILIAGRLGDI-FGHKKFFVLGFFWYALWSLLAGFSVYS---NQIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPG-RRKNMVFSLFGASAPGGF--FLGAVFSSMLGQ--L--A---WWPW-AY---WIMGIACFVLAVAGYFVI--------PH---------TPM--------------------------------------------------------------------------------------PSRDA--------SS------FKLL-----------ERI----DFAGSVTGVVGLILFNFAWNQG--------PVV----GWQT------PYTYALLIVGTFF-L-VIFAY--IE---------------------S-----RAA-F----------P-LLPFAAL--SSDTAFVLSCIAAGWASF-GIWIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFC-AAVTTGFLLS-----------HTPP-STVMLFAMTA-FTVGTILI-----ATA----------------------------PV--H------QTYW-AQTFVSIIVMPWGMDMSFP-AATIMLSDSMP-HE------HQGLAASLVNTVVNYSISIGLGIAGTI-E--SRVN-------------------------------------------DGGAK---------------------------PLKGYRCSWYMGIGLSGLGIFV--AATYAW---S---TF-----MKS------KK---------------------------------------RISEKQHFIE----------------------------------------------------------------------------------------- 'Saccharomyces paradoxus NRRL Y-17217 sapa c93 21663' -------------------------------------------------------------------------------------------------------------------------------------------------MSTSSSVTQKNLDTNAGA----------------------------------------------------------------------------------------------------LKKEDEVLSEFDIQDERPKSLLWESAFVGVLCSAQLMTQAGLGQSLAPLHIIGNSFG------TTNAGQLSWFASAYSLTVGTFILIAGRLGDI-FGHKKFFVLGFFWYALWSLLAGFSVYS---NQIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPG-RRKNMVFSLFGASAPGGF--VLGAVFSSMLGQ--L--A---WWPW-AY---WIMGIACFLLAVAGYFVI--------PH---------TPM--------------------------------------------------------------------------------------PSRDA--------PS------FKLL-----------ERV----DFAGSVTGVVGLILFNFAWNQG--------PVV----GWQT------PYTYALLIVGTFF-L-VIFAF--IE---------------------S-----RAA-F----------P-LLPFAAL--SRDTAFVLTCIAAGWASF-GIWIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFC-AAVTTGFLLS-----------HTPP-STVMLFAMTA-FTVGTILI-----ATA----------------------------PV--H------QTYW-AQTFVSIIVMPWGMDMSFP-AATIMLSDSMP-HE------HQGLAASLVNTVVNYSISIGLGIAGTI-E-------SRV--------------------------------------NDGGAK---------------------------PLKGYRCSWYMGIGLSGLGIFV--AALYAW---S---TF-----MKS-----------------------------------------------KKRVSEKQHFIE--------------------------------------------------------------------------------------- Saccharomyces_kudriavzevii_IFO_1802_saku_c2036.7 ------------------------------------------------------------------------------------------------------------------------------------------------MSISSPVMQKDFDTNTGTL----------------------------------------------------------------------------------------------------KKDDEVVLDEFDIQDETPGSLLWETAFVGVLCSAQLMTQAGLGQSLAPLHIIGKSFG------TTNPGQLSWFASAYSLTVGTFILIAGRLGDI-FGHKKFFVLGFFWYALWSLLAGFSVYS---NKIFFDCCRAFQGMGPAFLLPNAIAILGRTYKSG-KRKNMVFSLFGACAPGGF--VLGAVFSSLLGQ--L--A---WWPW-AY---WIMGIACFFLAIAGYFII--------PH---------TAM--------------------------------------------------------------------------------------PSRHA--------SS------FKLL-----------ERV----DFAGSVTGVIGLILFNFAWNQG--------PVV----GWQT------PYTYILLIVGTVF-L-AIFAF--IE---------------------S-----RAA-F----------P-LLPFAALSSDTAFVLSCIAA--GWASF-GIWIFYTWQFMEDSRGQTPLLSSAQFSPVAVSGFC-AALTTGYLLS-----------RTPP-STVMLFAMTA-FTAGTILI-----ATA----------------------------PV--H------QTYW-AQTFVSIIVMPWGMDMSFP-AATIMLSDSMP-HE------HQGLAASLVNTVVNYSISIGLGIAGTI-E--SNVN-------------------------------------------DGGAK---------------------------PLKGYRCSWYMGIGLSGLGIFV--AAIYAW---S---TF-----KKS-----------------------------------------------KKRTSEKQHFIE--------------------------------------------------------------------------------------- Saccharomyces_mikatae_IFO_1815_sami_a_c511_20564 ------------------------------------------------------------------------------------------------------------------------------------------------MTLSSPVTEENLDMNVETL----------------------------------------------------------------------------------------------------KKDDEVLSDEFDVQEEKPESLLWESAFVGVLCSAQLMTQAGLGQSLAPLHIIGDSFG------TANPGQLSWFASAYSLTVGTFILIAGRLGDI-FGHKKFFVLGFFWYALWSLLAGFSVYS---NQIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPG-RRKNMVFSLFGASAPGGF--VLGAVFSSMLGQ--L--A---WWPW-AY---WLMGIACFLLAVAGYYLI--------PH---------TPM--------------------------------------------------------------------------------------PNRDA--------AS------FKLL-----------NGI----DFAGSVTGVVGLILFNFAWNQG--------PVV----GWQT------PYTYALLIVGTVF-L-IIFAF--IE---------------------S-----RAA-F----------P-LLPFAALSSDTAFVLSCIAA--GWASF-GIWIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFC-AALMTGFLLS-----------HTPP-STVMFFAMTA-FTVGTILI-----ATA----------------------------PV--H------QTYW-AQTFVSIIVMPWGMDMSFP-AATIMLSDSMP-HE------HQGLAASLVNTVVNYSISIGLGIAGTI----ESNV------------------------------------------NDGGAN---------------------------VLKGYRCSWYLGIGLSGFGIFVAATYAVST-------FM-------------------------------------------------------KSKKRVSEKQHFIE------------------------------------------------------------------------------------- Saccharomyces_mikatae_IFO_1815_sami_b_c1722.1 ------------------------------------------------------------------------------------------------------------------------------------------------MTLSSPVTEENLDMNVETL----------------------------------------------------------------------------------------------------KKDDEVLSDEFDVQEEKPESLLWESAFVGVLCSAQLMTQAGLGQSLAPLHIIGDSFG------TANPGQLSWFASAYSLTVGTFILIAGRLGDI-FGHKKFFVLGFFWYALWSLLAGFSVYS---NQIFFDCCRAFQGMGPAFLLPNAIAILGRTYKPG-RRKNMVFSLFGASAPGGF--VLGAVFSSMLGQ--L--A---WWPW-AY---WLMGIACFLLAVAGYYLI--------PH---------TPM--------------------------------------------------------------------------------------PNRDV--------AS------FKLL-----------ERI----DFAGSVTGVVGLILFNFAWNQG--------PVV----GWQT------PYTYALLIVGTVF-L-IIFAF--IE---------------------S-----RAA-F----------P-LLPFAAL--SSDTAFVLSCIAAGWASF-GIWIFYTWQFMEDSRGQTPLLSSAQFSPVAISGFC-AALMTGFLLS-----------HTPP-STVMFFAMTA-FTVGTILI-----ATA----------------------------PV--H------QTYW-AQTFVSIIVMPWGMDMSFP-AATIMLSDSMP-HE------HQGLAASLVNTVVNYSISIGLGIAGTI-E--SNVN-------------------------------------------DGGAN---------------------------VLKGYRCSWYLGIGLSGFGIFV--AATYAV---S---TF-----MKS-----------------------------------------------KKRVSEKQHFIE--------------------------------------------------------------------------------------- 'Saccharomyces castelli NRRL Y-12630 saca 696.43' ---------------------------------------------------------------------------------------------------------------------------------------------------MENKEPIVSSSQKKTL----------------------------------------------------------------------------------------------------SCDSLLENSTPWQNEQYFQSHLKEYFFIFTCMFANLLNQAGQTQVLSTMNVISESFHS-----DVGT--QTWLMASFPLVSGSFILISGRIGDI-YGLKKTMIGGYIFMIIWTLLCGFADYTH--SDTFFIVCRAFQGLGISFILPNIMGLVGNIYKVGTLRKNIVISLIGITAPTGA--CMGALWGGLIAT-----ESSRQWPW-IF---YAYALAAFVNLIMAIYSV-------PEN--------------------------------------------------------------------------------------------------VPTNV--------HN---------------------FAM----DWMGAIIGVVGLILFNFVWNQG--------PVN----GWAK------PYIIVLLIISIIF-L-VAFII--YE-L-------------------K-----FPI-S----------P-LLPREVT-KNGQILTILGILFLGWGSF-GIWTFYYYAFQLNLRNYSPLWAGATHFMFIIWGSI-AAFIVGFTIN-R---------VGPA--VLLFFSALG-FTMGSLML-----SVT----------------------------PI--H------QTYW-RMNVGMQIILSFGMDLSFP-ASSIILSDHLP-MQ------YQGMAGSLVNTIINYSTSLCLGMGTTV----ERQI------------------------------------------NKTGEE---------------------------LLRGYRSALYLAVGLGGLGACV--AFLNLC---Y---DL-------------------------------------------------------WRKRKSRLDDIRSLNTNDSA------------------------------------------------------------------------------- Candida_dubliniensis_CD36_cadu_10040 ------------------------------------------------------------------------------------------------------------------------------------------MSDSTSSNSVDEFIPHTVNELGKKS----------------------------------------------------------------------------------------------------SNVTVTTVSQLPEPNYESISVIREILFMFFMCMSQLLTQAAVSQTMNTQLKIADTYSIQD---DPGE--MSWFAASFSMTAGTFILVSGRLGDM-YGYKCLYIIGYLWFGVFSLLCGFAGLTK--SNIFFTTMRGLQGIGPALMMPNSQALIASFYPES-FKKNVCLALFGAIAPSGF--VVGALFSGLLAD--L--A---KWQW-TF---WLCGIVSICLAALAFLII-------PKK--------------------------------------------------------------------------------------------------IGLKS--------GG--------KF------------------DFWGSLFGVSGLVLINFAFNQG--------PNI----GWHV------PYVYVLLIVGFLC-I-VAFHF--VE---------------------E-----RVE-D----------P-LVPKEALQGDTGFILGCIAA--GWSCF-GVWLFYTLRWSLVVDNDNTVMSAVKMIPCGPMGVI-AAISGAVLLM-----------KIPS-AIVMFLAMMA-FFIGIVIM-----GTR----------------------------PV--G------QIYW-AQKFVSLLIQPIGMDMSFP-AACILLSSSLP-SR------QQGIAGSLVSTFVNYSISIGLGFAGTV-E--YYTT-KNK-------------------------------ESNLNT----------------------------------SILGMRNAFRMGMGLAGVGVVL-SSIFMLI-------QI-------------------------------------------------------INRRKSARLQDI--------------------------------------------------------------------------------------- Candida_guilliermondii_ATCC_6260_cagu_02196 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MARPAVFKSCLHEISTVYMICLAQFLAQGGVLMALSTKNIILQSFNDPNF--DHSQ--AVWFMGSFALTVGTFILISGKIGDV-FGLKLVFVVGWVWVSILSIITGFSYYSK--SVIFFIICRALQGIGFALILPCGMGILGTLYPNGE-RKNIAFGCVGASGPSGA--FFGAFMAAVIAQ--L--A---WWPW-VF---WIMGIVAAIGAVISYWVI-------PME---------LTN--------------------------------------------------------------------------------------KECST--------RE--------KL-----------RRI----DTYGSLTGVAGLVLLNFVWTQG--------PVV----GWGT------AYIIILLVVSLAL-T-GIFFY--LE-V-------------------K-----VIE-M----------P-LLPAGVF--NRKIGLCLLCLGLGWGSF-GIWQYYYWSLLLDLRHYTSIHGGLTYLTFCIMGII-AALSCGFIMS-----------RTSP-SYIISFASIA-FMCGCIML-----SVT----------------------------PV--K------ESFF-RMSFGQLFILVWGMDLSFP-AASLILSDNLP-IE------QQGMAGSLVTTVTNFSVSLILGISSTA-E--------------IEV-------------------------------FRRTGD---------------------------TLSSYRAALYLGIGVSGLGVLC--SFVFIY---Q---QL-----KES--------------------------------KQIKEQEKMGEIDQENHESTLRPTTDKSDLTEQALDISISN------------------------------------------------------------------------- 'Kluyveromyces waltii NCYC2644 klwa 333-snap.4' -----------------------------------------------------------------------------------------------------------------------------------------------------------------MQ----------------------------------------------------------------------------------------------------DEFGKLRNGLKCLRLKCQNSRYQLGINITLIFFGCTFDLLNVAGVISVIEDLGETYKL-----GYTG--ASWALTSYAITFAGFIAFMGRLGDI-VGNSVLFTISCFLFTLFSLLCAVVR-----DFPTFAVFRALQGISAAGIVPCGYALIPLLAEPQ--DIQKFFSIVSCGFSSTI--GIGLIVGGAFAL--T--KV--GYAG-IF---YLSFAGMLVVSIAASFYT-------YRI-------------------------------------------------EERKFLEVKVEDI------------------------------------PHDHP------------------KV-----------ASL----DFVGSLIFVSGSVLIVAGLTEGGE-------------SWRR------PVAYVPFSIGVLL-F-CSFFI--WN-CYYQKMVSRLKAVGF-NTPQY-----LNNVQ----------V-LVPKDVL-FMPNFIPIILSFACNNACL-FSVIYIIDQYSQYVEKNSPLIAGVRLIPLIVSMVI-GNTTCAIRSL-----------QLRP-KVGVVLGFLF-MLCGSIIL-----IQL----------------------------HTIEN------GIFW-KLFFCSQISVGLGAAIFYP-YALKLVVGGAP-DG------AKGIASGMTQTFAQFGVEVTFSVMVSV-L--GNIT------------------------------------DVKET-LNSQET---------------------------FKDRFQNCAYFSVAVAALGLIL--TLCLSN-------KQ-----KPI-------------------------------------------------------------------------------------------------------------------------------------------------- Candida_albicans_SC5314_caal_a_19.2350 -------------------------------------------------------------------------------------------------------------------------------MSDCTSSNSVSVEE--------FNPDPVNELEKKES----------------------------------------------------------------------------------------------------NVTVTTVSQLPEPNYENISVIR-EILFMFFMCMSQLLTQAAVSQTMNTQLKIADTYSI--QD-DPGE--MSWFAASFSMTAGTFILVSGRLGDM-YGYKLLYIIGYLWFGVFSLLCGFAGLTK--SNVFFTTMRGLQGIGPALMMPNSQALIASFYPES-LKKNVCLALFGAIAPSGF--VVGALFSGLLAD--L--A---KWQW-TF---WLCGIVSIGLAALAFFII-------PKK--------------------------------------------------------------------------------------------------IGLKS--------SG--------KF------------------DFWGSLFGVSGLVLINFAFNQG--------PNI----GWHV------PYVYVLLIVGFLC-I-VAFHF--VE---------------------E-----RVE-D----------P-LVPKEALQGDTGFILGCIAA--GWSCF-GVWLFYTLRWSLVVDNDNAVMSGVKMIPCGPMGVV-AAIGGAILLM-----------KVPS-AVVMFLAMMA-FFIGIVIM-----GTR----------------------------PV--G------QIYW-AQKFVSLLIQPIGMDMSFP-AACILLSSSLP-RH------QQGIAGSLVSTFVNYSISIGLGFAGTV-E--YYTT-KNK-------------------------------EPNLST----------------------------------SIFGMRNAFRMGMGLAGVGVVL-SSIFMLL-------QI-------------------------------------------------------INRRKSTRSQDV--------------------------------------------------------------------------------------- Candida_guilliermondii_ATCC_6260_cagu_05806 ------------------------------------------------------------------------------------------------------------------------------------------------MSMSSERTTLEHEPQILAM----------------------------------------------------------------------------------------------------KEEGEKDAHTNAVPSCDEIGFFHEVVFVFCMCCGQLFSQAAVAQAIAATKGIANTFGV-----EDSPGEQAWFTASFSSTVGTFILASGKFGDM-FGYKFMYITGVLWFALWSLICGFSAYAK--SAVFFDVCRALQGAGSALLFPNGIAVLGHYYPPGSMKKNIVMCLFGAAAPSGF--NIGALFSSLFAM--K--V---WWPW-TF---WVCGIASVCLAVLSYLFV-------PKK--------------------------------------------------------------------------------------------------IGTPS--------RK---------------------EPF----DWIGSTLGISGLILFNFAWNQG--------SNV----GWKT------VYNYVLLIVSVGL-V-VAFDI--VE-V-------------------------YLK-H----------P-IVPIKSLKGEPSFVLGCIAA--GWSCF-GIWLYYTFQWAFYVDNVNPVVASVQFIPCSISGFI-AALTTAYLLH-----------KIPS-SFVMMLSMCA-FFAGITVM-----GTR----------------------------HV--G------QTYW-GQKFVSCLIQPFGMDMSFP-AATIILSNHFP-PS------KQGISASLVATVQNYSVALGLGFAGTV-E--KYKT-----------------------------------DHLPQT-------------FDS------------------KLLGIRVAFYMGMGLAGLGVVF--SVIGGI---L---QW-----KED-----------------------------------------------RKAKVDKAQAIRNEG------------------------------------------------------------------------------------ Pichia_pastoris_GS115_pipa_3g00675 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLKIPRPTKVDPRPECFSSTLKECFCIFTLTFAPAAASMATGAYQISINKVADHFHV-----AGGA--LTWSISSVGLANGSLLLLMGSIADL-FGRRYSVLTAFTLYSMFSLIGGFMN-----NYIALCIFRALQGVVVAVGTPAAAGIIGANYPIG-RRKNRAFACFAAGAPLGM--CFGLVVGGIAAEFST-------WRA-IH---FFNTVWYALLATVAFITV-------PKD----------------------------------------------------QDTELSK---------------------------------------KGKLA------------------TL-----------KEL----DYMGAFLSLTGFTLFCFSLTQVDV------TVH----GWKT------PYIIALLIVGSLL-I-VALFV--WE-K-------------------Y-----VPR-R----------P-LMPMEMW-SNSRFARSITIMSLLWLCFAGTLTYFSILFFENVQARSPLLTTAYILPMGIVGIL-TNIFIAFTLHVI---------PGRI----LLLAASL-SFCGSAVI-----WAT----------------------------VS--K------NRLYWAGPFQAISLSVIGADTAYN-VCNMVTMTSVS-KD------LQSSAAGVFNTVIQLSGAVGLAISSAV-VNARNPL------------------------------------------YGTPQQ--------------NDDPVK-------LLDGFRNAWYCAIGYSVVAVVL--SCFLKI---G---TY-----GNS-----------------------------------------------QHEEAEPEIASETLPQGFDGKTSP--------------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0d01386g --------------------------------------------------------------------------------------------------------------------------------------MWFKRSNESVSSQSKELGTQSATAFTEHS----------------------------------------------------------------------------------------------------DVQVDDKKWPSIQDPTYFSAPWKEYLFIFASMMSQLLNQAGTTQTLSLINILSKNFDS-----STSQ--QTWLMASFPLVSGSFILVSGKIGDI-YGLKKTLLVGYVVTIIWSLICGLTSYTS--SVEFFIISRAFQGLGIAFILPNIMGIVGNIYVAGTTRKNMVISLIGACAPIGA--TMGVLFSGLIGT--L--S-E-RWAW-TF---YAYTITAAINMGLSIWVI-------PNT--------------------------------------------------------------------------------------------------IPTNV--------RG---------------------SSM----DWIGSGIGLLGMILFNFVWNQG--------PIV----GWDT------AYIIVLLIVSVAA-I-VAFFL--YE-T-------------------K-----YAN-D----------P-LIPRPAM-HNHRLLMTLLAVFFGWGSF-GIWTFYYFCFVLNLREYTPLWAGGSYFMFLIWGII-AAISVGYTIK-----------RIPP-SLILFLSMLA-FDCGCIML-----SVT----------------------------PV--D------QTYF-RMILGMMIILSFGMDLSFP-ASSIILSDELP-ME------NQGMAGSLVSTMINYSMSMCLGIAGTV----EHQI------------------------------------------NKNGDD---------------------------LLKGYRAALYLGIGLASLGVFISALFMLEN-------YL-------------------------------------------------------RMRRRNVKEEV---------------------------------------------------------------------------------------- Candida_guilliermondii_ATCC_6260_cagu_05180 -----------------------------------------------------------------------------------------------------------------------------------------------------MDENSSLIPDEDDI----------------------------------------------------------------------------------------------------TDSAKLQNDQTDFQNDFMSIN--KWAIIPSLWCGAFLAALDSTIITATYTVIGTEFK------KSEQ--ASWIATLYMLSSSAFQPLYGGLSDM-FGRKIVLVYANAIFLLGSFGCYLAQ-----TMTQLLVARVVAGIGGAGLGTLSSIIVSDLVPLK--ERSTYNGFANLVFGIGQ--VIGAPVGGYLAD--S--L---GWRY-AF---LIQCPITAISILIIHYRV-------RLP--------------------------------------------------------------------------------------------------VKSSA--------RA--------RL-----------RDI----DFVGSIFLIGAVILALLALQFSKS-------------RGAS------QITLLTLCCSICC-F-MLTFY--VE---------------------S-----VVQ-N----------P-IISIKVL-LSRNPLLSGLTNFFGYMGF-FSITFNIPLFLQVIHDEPASKAGSRLITSVVGMCV-GSLTAGVITR-K---------TKRY-YELVVLGVIC-EIVGSVLV-----STF----------------------------SQ--E------TAS--WKFQLYLFPSGLGHGLVLS-STLMAIISSVK-KS------EQAKATSMSYLFRVLGSAFGVSLTSTL-N--SFLL-RKWLTVALEN--------------------IPGNKQITDKVMHSFLD-----------IRNLPQGIRSLVKQE-FAGMLHTSFSLVILIEFVSLSF--AVFIKQ---Y---SL------DR-------------------------------------------------------------------------------------------------------------------------------------------------- Kluyveromyces_thermotolerans_CBS6340_klth0c03806g ---------------------------------------------------------------------------------------------------------------------------------MNSEYTPVSKQR--------TGSDISRKVVDNHE----------------------------------------------------------------------------------------------------DSDMLLASRSRLQNPDYFDKQWKEYLFVISSMLSQLLNQAAALQANPLFDLLSEDLKA-----KASQ--QAWLMASFPLVSGSFILVSGKVGDI-YGLKKTLLGGYAVVVIWSLICGLSSYAH--NVDFFIVARSFQGLGIAFVLPNVTGIVGNIYKPNTKAKNMVFSMIGACAPIGA--TLGCLFSGLIGT--E--S-E-AWAW-TF---YAYTIVAALNGLIAWYVI-------PDN--------------------------------------------------------------------------------------------------IPTNV--------HK---------------------FKM----DWLGSFLGVCGLIMFNFVWNQA--------PTD----GWDS------AYIIVLLVISVIL-L-LIFII--FE-A-------------------R-----FAK-E----------P-LLPRAVL-FNRKLMMILASLFLGWGSF-GIWTYYYMAFVLNLRHYTPLWAGGSYFMFAIFGTI-AAFLVGHTIH-K---------TGPA--IILLASVIA-FDVGCIML-----SVT----------------------------PV--D------QTYF-RMSLGTMVILSFGMDLSFP-ASSIILSDQLP-SQ------YQGMAGSLVNTMINYSMSLCLGVSGTA-E--RQVN-------------------------------------------KDGTD---------------------------LLKGYRAALYVGIGLASVGIFV-SGAYAIE-------DW-------------------------------------------------------WTRRRERSVRIKLDEKHQE-------------------------------------------------------------------------------- Pichia_stipitis_CBS_6054_pist_igi16597754 -----------------------------------------------------------------------------------------------------------------------------------------------------------------KE----------------------------------------------------------------------------------------------------EVFEESNAGDGTRREDQYLHGYRLALCVVALLLSLFIMSISQTIILIILTEVGNKFD------GVGK--INWITSGYLLAIAVLTQTWGKLSIL-IGRKLTLSISLIFFEAGTLLCALSN-----SMDMLIGGRVLAGVGAGGIQASVFVVLSEVLPIQ--YRTYGMMLMSMTGTTAS--IIGPLIGGALSR--V------SWRW-CF---YFNIPIGGAAFVYLQLFF-------NPP-----------K--------------------------------------------------------------------------------------PKGKL--------LK--------KL-----------KLL----DYVGTLLVCGAAVLILLGLSFGSN------QEF----DWKS------APVIVCLTVGGLL-L-IAFLI--WN-F-------------------N-----YSK-Y----------P-LIPVDVA-KSWQVEASVLTGCAMFGYF-FSNQIYISVYFQVIHGWNAWESGLHLLPLIISSVI-SSIGGSLLIQ-K---------TKFI-KPFSIFAAAC-GLVGNSIL-----YLL----------------------------DV--D------SNL--AKIIGLLILPGLSTGMQVQ-STVMLVQVSAP-KTAG----STIMATTYYNFLRTLCGAVAADLATLT-Y--NESL-KSKLTHALSN---------ITDPA-----LAQELSSIELSEILSNTT------ILN----QLSSAAQYFIKNE-IMGAIRNVFHVSAGFGGLCLIA--SCFQVN---H---RL-----P---------------------------------------------------------------------------------------------------------------------------------------------------- Kluyveromyces_polysporus_DSM_70294_klpo_541.16 -----------------------------------------------------------------------------------------------------------------------------MDTDLKKKNIEVSSYI--------AEETIRSDCSDAND----------------------------------------------------------------------------------------------------ESPSMELKNSSLRNPDYFNSTTQEYAFIFSCMLSQLLNLAGTTQTLSIMNVLTRQLHS-----SDSL--KVWLVASFPLVSGSFILVSGRLGDI-YGLKKMLILGYVILVIWSLITGLSGYS-H-SGIFFIIARAFQGLGISLVLPNVLGLIGMIYKPGTLKKNMVISIVGAMSPIGA--TLGGLFSGLVAT-----ESEGSWPW-AF---YAYTLAAFINTFISYYSI-------PNN--------------------------------------------------------------------------------------------------IPTNV--------NR---------------------LSM----DWIGSFTGVLGLILFNFVWNQA--------PAD----GWNS------AYLIVLLVISVIA-L-IAFGI--YE-L-------------------R-----YAE-N----------P-LLPSEII-RNRQLIMILTAMTFGWGSF-GIWTFYYFSFVLNLRNYSPLWAGGSYFIFVISGTI-TAISCGFLMK-----------KIRP-AVLLTFSMVG-FNLGCIIF-----SVT----------------------------PV--H------QTYF-RNILGTMIILPLGMDLSFP-ASSIILSDNLP-NQ------HQGMAGSLVNTVINYSNSLFLGIAGTV----EQHC------------------------------------------NKNGTD---------------------------LLRGYRGALYFGIACSGVAVLI-AGLYMVE-------TI-----FDS-----------------------------------------------YKDRKEKDCENCEQ------------------------------------------------------------------------------------- Candida_glabrata_CBS138_cagl0l02519g -----------------------------------------------------------------------------------------------------------------------------------------------------MSKSNLSSTSTSSD----------------------------------------------------------------------------------------------------TEYSAEKLTEVDTSIRLPKTWIREIFLVIILISSQLVTLIGAVQGVPIAAYLRERYRIEPA--KGGL--VGWANASYMLGSAVMVLIAGKLGDL-NGHKRMVVFGWIWLTIWSLITGFSYYD-RGNQAFYYTARALQGIGSGFIVPNSLAIMGRTYFEPGLKKTIIFSIFGMMTSTGF--VIGTTFSSLFAQ--L--T---KWAW-NY---WALACVCVLYTVGAILFI-------PPDNIV-----------------------------------------------------------------------------------------------HKPNS--------KP--------LY-----------KRF----DYLGAITGVSGLVLFDVAFTQA--------SAL----GWSP------PHTYITLIIGVILILIAMFVD--WR---------------------------VDD------------P-LVPLQHL--RADVVVILICVYFGFLSF-VIWANWFWQFYELVHNDSPLRIAAKLVPLAIGSIP-AAIFTVTCLQ-L---------NIKA-PTMMVISMVC-FLVPNILM-----ATV----------------------------TP--N------TTYW-AQPFVSSIIAPFAVDITVP-TATLLFSDSVR-KE------SQGIAASLIITVISYAISIGPSYTAMVMW------------------------------------------------YVAPLG-------------NDSTPGG-------FTHSLHSNFICGIVLSGIGLVTAVIAGLID---Y---KI-------------------------------------------------------TRTHCGDIPPPLSKIGRKSKK------------------------------------------------------------------------------ 'Lodderomyces elongisporus NRRL YB-4239 loel 03562' -----------------------------------------------------------------------------------------------------------------------------------------MSDHSLDLDANSAASETPRNEKQENI----------------------------------------------------------------------------------------------------SKQTTREEVYHSQPNFEEISFPHEAAFIFLMCMSQLLTQAANAQAMPTMVIVGRAFGVED---KPGE--ISWFSAAYSLTVGTFILTSGRLGDM-FGYKKMFIIGYLWFGIFTLLVGFAGLTK--SVVFFTTMRGLQGIGPAIMMPNSQALIGNFYPNI-FRKNVCFALFGAVAPNGF--IVGALFSSMFAH--V--A---WWPW-TF---WVCGIVSIVIAGIAFFVI-------PNK--------------------------------------------------------------------------------------------------IGSKS--------KG--------SF------------------DYWGSISGVSGLVLINFAFNQG--------PNV----GWDK------VYVYVLLIAGFLC-M-GAFYF--IE---------------------K-----RVQ-D----------P-LVPPEV--LKGDTGFILACISAGWSCF-GVWLYYQFRWALLVDNDSSVMAAVKNIPAGPVGII-AAIAAAYLLT-K----------LPS-ALVMFFAMIA-FLAGIIIM-----GTR----------------------------PV--G------QIYW-AQKFVSLLVQPIGMDMSFP-SAVILMSAALP-RH------QQGIAGSLVSTFVNYSISIGLGFAGTV-E-----------------------------------------YYTTKD-MQTGFD--------K------------------TVLGMKNAYRMGMGLAGFGVVV--STIYLY---L---QL------KN------RR------------------------QNNIN----------SEDSTTLEDEEAK-------------------------------------------------------------------------------------- Candida_parapsilosis_CDC_317_capa_03043 --------------------------------------------------------------------------------------------------------------------------------------------------MSDDATINSSTEVDAKV----------------------------------------------------------------------------------------------------TENENQGDVYRSVPNFQQISLLHESIFIFFICMSQLLTQAANAQTMVNSVVLGKAFNVAD---NAGQ--ISWFSAAISLTVGTFILVSGRLGDL-YGYKKLYIIGYLWFGVFSLLCGFTGFTT--SHVFLSTMRGLQGIGPAIMMPNSQALVGNFYPNG-RRKNMCFALFGAVAPSGF--IIGALFSGLFTD--V--V---WWPW-TF---WLCGIVSIALAILAFFVI-------PAK--------------------------------------------------------------------------------------------------VGSRS--------PG--------KF------------------DYWGSITGVSGLILINFAFNQG--------PTV----GWEK------VYVYVLLIVGFLL-M-GAFFF--IE-K-------------------K-----VAD------------P-LVPPEV--LRGDTGFILACISAGWSCF-GVWLYYQFRWALLVDKHSEVVAAVQNVPCAPVGVI-AAVGVAILLT-K----------IPS-AVVMFLSMLA-FLVGSILM-----GTR----------------------------PV--G------QTFW-AQKFVSLLIQPLGMDMSFP-AAVILLSAALP-RH------QQGIAGSLVSTFVNYSISIGLGFAGTV-E-----------------------------------------YYTTKD-KPQNFD--------T------------------TVLGFRNAYRMGMGLAGFGVVV--AAVYMF---K---QF------QS------RK------------------------RELERREF-------SEERLARGQEQEKTTESTVPV------------------------------------------------------------------------------ Debaryomyces_hansenii_CBS767_deha2c03718g -------------------------------------------------------------------------------------------------------------------------------MESSCRDNIDLNRD--------VSQDSNYIEEDEIL----------------------------------------------------------------------------------------------------EIKSSISTLKPTPPPEEISVGR-EILFLLCMALQQMLTQAGVAQTTNPSTPIAEQFGV-----EDLNGEKSWFTASYSLTVGTFILIAGRLGDM-YGYKKMYLIGFAWFALWSLVVGFSGFT-K-SQIFFDVARALQGMGPALSTPNAMALVGHYYPKG-FRKDLCMCLYGSVAPTGF--MLGALFSGIVAQ--L--VDSMALPG-VFLGYFLMAIVCVIFLVVGYFAI-------PEN----------IG--------------------------------------------------------------------------------------NVDPE--------KE------EGSF------------------DWLGSFFGVSGLVLINFAWNQG--------PNV----GWDK------PYVYVLLIVGFIL-I-GLFFV--AE---------------------G-----KVK-D----------P-LVPSAA--LKGETGFVLGCIAAGWSCF-GVWLYYTFQWNEFVDGQTAIIGGVHFVPAAIVGYV-AAALTAVLLQ-K----------LPL-SIVMHFAMLF-FFVGIVLM-----GTR----------------------------PV--G------QIYW-TQKFFSLIIQSFGMDMSFP-AATVILSNSLP-KA------QQGIAASLVATFQNYAISIGLGIAGTV-E-----------------------------------------YYQTRN-LPDSLE--------T------------------DIHGFRVAFYMGMGLAGCGVVL--SLIFIL---K---QA------KD------NA------------------------QRRK---------------LEKSEKPAV-------------------------------------------------------------------------------------- Candida_glabrata_CBS138_cagl0b02343g -----------------------------------------------------------------------------------------------------------------------------MGIFRKSGTDSVQQETLSSSSSGSSFKQDNNDIVDEKQ----------------------------------------------------------------------------------------------------CDTQAIDGNQKWQNPEYFDSTLKEYLFLCSCFVSQLLNQAGAIQTQPIMNIVADSLDS-----QNGK--QAWLMAAFPLISGSFILISGRIGDI-YGLKKTLLVGYLFLIVWSLICGLTKYAH--SDSFFIVSRAFQGLGISLILPNILGIVGSIYIAGSKRKNMVISLIGCMAPIGA--TLGAVFSGLIGT-----EDANQWPW-AF---YSYAITAAINFVLSIWLI-------PNT--------------------------------------------------------------------------------------------------IPTNV--------HG---------------------HKM----DWIGSGLGVVGLIMLNFVWNQA--------PID----GWDS------AYLIVLLIISVLL-L-IAFFI--YE-L-------------------H-----FVNGN----------P-LLPKEVL-KSPKTIIVLFALFFGWGSF-GIFSFYYFTFQLNLRHYTPLWAGGTYFMFLIWGIV-AALVVGFTIK-----------KVYP-SIILFLSMVA-FNCGSIIM-----SVT----------------------------PI--H------QTYF-RNHLGMMIILSFGMDLSFP-ASSILLSDKLP-LQ------YQGMAGSLVNTMVNYSMSFCLGVAGVV----EQHV------------------------------------------NNHGKD---------------------------VLKGYRGAFYLGIGLASMACIISGALMLSE-------II-------------------------------------------------------QGRKNEKDSAVVEIAK----------------------------------------------------------------------------------- 'Candida tropicalis MYA-3404 catr 05874' --------------------------------------------------------------------------------------------------------------------------------------------------------------MSEKS----------------------------------------------------------------------------------------------------IAEVKQLSEQLGDVHYNILPLRKLLICLGCLSLALFVSFVDQTGLTIALPTIGRDLN------SEST--INWAPTASLLANTVCQVIFGRLSDI-FGRKIMLILCLFGLSIGDLICGFVK-----TGIEFFIFRAITGLSCGGIQSLCMVILSDVVSLR--QRGKYQGILGASVGLGN--SIGPFLMSSFIE--N--N---SWRN-FY---HMMSPLVFLIMIVNLIFI-------DNK----------------------------------------------------QQSKELK---------------------------------------SIITK--------SQ--------QF-----------KKL----DYWGILFGCSSIILLLIPISGGG-------STY----PWNS------SLVISMFTIGGAL-F-LVFLLVEWK---------------------------IPE-L----------P-MIPMTLF-TRISLALILGSNFFFGMAY-YGFTFYIAYYYQIVRGLDSIHSSILMLPLVIPQSV-VSVISGQIIS-Y---------TGHY-IYVVIFGYSI-WTLSCGLT-----LLF----------------------------DL--N------TNY--GIIVIVLLLMGSGVACTFQ-PTMVAAQSQAK-KS------ERAVVISCRNVIRSFGGAMGLAIASLI-I--SNTL-ISE----INH-----------------QRSQGVLPNDYLN-YMQNHI------YSKIDTSVLTHDQVVVVRQM-YMTSIRNFFYLTIPLLAICLIT--NLFVKD---K---GL-----QCI-----------------------------------------------DEEPEE--------------------------------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0f00198g ---------------------------------------------------------------------------------------------------------------------------------------------------MDNCGKVIESMGVIVE----------------------------------------------------------------------------------------------------DRSSAQDESSGHVGDPQPLSGFKLYANMGSLTLVLFLAALDILIMSASIEVISEQFN------DYSK--SGWIVSGYSLPEALLTLLWGRFATI-FGFKLSLLLSILIFETGSLISAVSN-----SMNVLIGGRVVAGIGGSGIQSLCFVIASTLTTER--SRGVAISVLSCAYAVAA--VASPFMGSAFTT--H--V---TWRW-CF---YINLPIGGLAFAVLVLTY-------KPH----------EG-----------------------------NSARSIVSVLKSCCEFGTARLFSKDL-------------------------------YLKMF--------NE--------LV-----------FGF----DFIGFIFCSVGFILFRLGLTFGG-------DKY----TWSS------GAIIVYFVVGVTI-S-VAFLL--YD-FMVFPKFGRVRK--------N-----ASF-R----------P-LVPWSVV-SRPGIATAVAANFLMCVAY-SAQVVYIIQFFQLVRGSDAWRASIHVVALEIPDII-TVAISGAISR-M---------TGHV-KPIIFVGIIA-GLVGAGLL-----TLL----------------------------DN--D------SGS--SKHIGLLILPGVAFGAMLQ-GSLLSCQLQIP-KDSASFMPDFVSTTTVHTFSISLGMYFGSVLATMV-F--GTSL---------------------------------------------------------------------------HNKIASSGFEFLSTKSVDKLVS-----------Y---RI-----QSF-----------------------------------------------DGTRSRLG------------------------------------------------------------------------------------------- 'Saccharomyces castelli NRRL Y-12630 saca 551.4' -----------------------------------------------------------------------------------------------------------------------------MSLPSILQTDSDNFSSSTVSFPNEDKNISHNEKEVYSN----------------------------------------------------------------------------------------------------STDSVLDDDSPWQNPNYFSSKYKEYFFIFTCMVANLLNQAGQTQVLSTMNVISESFHS-----DSGK--QTWLMASFPLVSGSFILISGRIGDI-YGLKKTMIGGYIFMIIWSLLCGFADFTH--NDTFFIVCRAFQGLGISFILPNVMGLIGNIYKVGTLRKNIVISMIGLTAPTGA--CMGALWGGLIVT-----ENAKQWPW-IF---YAYALTGLVNLIMALYSV-------PNC--------------------------------------------------------------------------------------------------IPTNV--------HN---------------------FAM----DWIGSIIGVVGLILFNFVWNQG--------PVA----GWDK------AYIIVLLIISVLF-L-VAFVV--YE-L-------------------K-----YPI-S----------P-LLPVEVT-KNGQILTILSILFLGWGAF-GIWTFYYFAFQLNLRDYSPVWVGGTYFMFIIWGTI-AALIVAFTIK-K---------VGPA--ILLFFSALG-FTMGSLML-----SVT----------------------------PI--H------QMYW-RMNLGMQIILCFGMDLSFP-ASSIILSDHLP-MQ------YQGMAGSLVNTVINYATSLCLGMGTTV----ERQI------------------------------------------NKSGED---------------------------LLKGYRSALYLAVGLGGLGSCI--AFINLC---Y---TL-------------------------------------------------------WMKRRDRLADLKSVSTDDSV------------------------------------------------------------------------------- Saccharomyces_kudriavzevii_IFO_1802_saku_c2070.4 -----------------------------------------------------------------------------------------------------------------------MLPSFERKMSVQGTSSPVNDKISMKEEDKVIVSTDEEVTTVASS----------------------------------------------------------------------------------------------------SKSNQISNDSPWQDPTYFSSFGKELMFIGTCMLAQLLNQAGQTHALCIMNVLSKSFGS-----ESNN--QAWLMASFPLAAGSFILISGRLGDI-YGLKKMLMIGYVIIIVWSIISGLSKYSN--NDSFFITCRAFQGVGIAFILPNIMGLVGHVYKVGSLRKSLVISVIGACGPTGA--LFGGVFGGLIVI-----EDPNQWPW-VF---YAFGIATFISMLMAWYSI-------PNN--------------------------------------------------------------------------------------------------VPTNV--------HG---------------------LSM----DWTGSVLAVIGLILFNFVWNEA--------PIA----GWDK------AYIIVLLVVSVFF-L-VAFFV--YE-I-------------------K-----YAE-V----------P-LLPHAVT-KNRHMIMILLAVFVGWGSF-GIWTFYYVSFQLNLRHYSPVWTGGTYFVFAIFGTI-AAFFVAFSIK-R---------LGPA--LLLCFALMA-FDAGSIMF-----SVL----------------------------PV--E------QSYW-KLNFAMQAVLCFGMDLSFP-ASSIILSDGLP-MQ------YQGMAGSLVNTVINYSASLCLGMGATV----EHQI------------------------------------------NKSGKN---------------------------VLEGYRAAVYLGIGLASLGVLISVTYMLET-------VW-------------------------------------------------------NERKKCQRKSLEA-------------------------------------------------------------------------------------- 'Saccharomyces bayanus 623-6C saba a 601.4' ----------------------------------------------------------------------------------------------------------------------------------------------------------------MLW----------------------------------------------------------------------------------------------------NKFARVGKALEKIRNRCQKSTYQLNVNVALIFLGCTFDLLNVASMISLIDDLAQKYDI-----SYTT--ASWSLTSYAVTFAGFIAFMGRLGDI-VGNSILFTVSCFFFAILSLLCAVMP-----NFPAFAVFRAIQGISAAGLVPCAYALIPMLAPEE--EVQKYFSIVSCGFSSTI--GLGLIIGGAFAA--T--KI--GYKG-IF---YLTFAVMFLISIVAFFFTYGVENLSEPP--------------------------------------------------------------------------------------------------RKDQA--------TN--------RV-----------RSL----DFIGSLIFVTGSILIVVGLTEGGE-------------SWNR------PATYVTLVIGIIL-F-FGFFF--WN-CSYARIVRGIRCCGI-DTSRY-----FEKVQ----------L-LIPVDVL-FMKNFIPIVLAFALNNACL-FSCIYIIDQYSQYEEKNSPLYAGVKLVPLIICMVI-GNGLCAFEST-----------KLKP-KVGVVLGFSL-ALAGSIIL--TQLHLI--------------------------------K------EDMFWKIFFSSQALVGFGVAIFYP-YALQIAVGGAP-DR------SKGIASGVAQTFGQLGIEITFSVMASV----------------LGN------------------------IDGIRGKSGASQK---------------------------FRTGFQNCTYFTVAVGALGFLV--TLFGLK----------------------------------------------------------------DTRPPTDDISDVESSIQRTKVEMDQEKSRI--------------------------------------------------------------------- Saccharomyces_bayanus_MCYC_623_saba_b_c68_15452 ----------------------------------------------------------------------------------------------------------------------------------------------------------------MLW----------------------------------------------------------------------------------------------------NKFARVGKALEKIRNRCQKSTYQLNVNVALIFLGCTFDLLNVASMISLIDDLAQKYDI-----SYTT--ASWSLTSYAVTFAGFIAFMGRLGDI-VGNSILFTVSCFFFAILSLLCAVMP-----NFPAFAVFRAIQGISAAGLVPCAYALIPMLAPEE--EVQKYFSIVSCGFSSTI--GLGLIIGGAFAA--T--KI--GYKG-IF---YLTFAVMFLISIVAFFFT---YGVENLS---------EPP--------------------------------------------------------------------------------------RKDQA--------TN--------RV-----------RSL----DFIGSLIFVTGSILIVVGLTEGGE-------------SWNR------PATYVTLVIGIIL-F-FGFFF--WN-CSYARIVRGIRCCGI-DTSRY-----FEKVQ----------L-LIPVDVL-FMKNFIPIVLAFALNNACL-FSCIYIIDQYSQYEEKNSPLYAGVKLVPLIICMVI-GNGLCAFEST-----------KLKP-KVGVVLGFSL-ALAGSIIL--TQLHLI--------------------------------K------EDMFWKIFFSSQALVGFGVAIFYP-YALQIAVGGAP-DR------SKGIASGVAQTFGQLGIEITFSVMASV----------------LGN------------------------IDGIRGKSGASQK---------------------------FRTGFQNCTYFTVAVGALGFLV--TLFGLK----------------------------------------------------------------DTRPPTDDISDVESSIQRTKVEMDQEKSRI--------------------------------------------------------------------- Saccharomyces_cerevisiae_S288C_sace0m09768g ----------------------------------------------------------------------------------------------------------------------MFSIFKKKTSVQGTDSEIDEKITVKAKDKVVVSTEDEEVTTIVSS----------------------------------------------------------------------------------------------------TKSTQVTNDSPWQDPTYFSSFGKELMFIATCMLAQLLNQAGQTHALCIMNVLSKSFNS-----EANN--QAWLMASFPLAAGSFILISGRLGDI-YGLKKMLIVGYVIVIVWSIISGLSKYSN--SDAFFITSRAFQGVGIAFILPNIMGLVGHVYKVGSFRKNIVISFIGACAPTGG--MFGGLFGGLIVT-----EDPNQWPW-VF---YAFGIATFLSLLMAWYSI-------PNN--------------------------------------------------------------------------------------------------VPTNI--------HG---------------------LSM----DWTGSALAIIGLILFNFVWNQA--------PIV----GWDK------PYIIVLLIISVIF-L-VAFFV--YE-S-------------------K-----YAE-V----------P-LLPRAMT-KNRHMIMILLAVFLGWGSF-GIWTFYYVSFQLNLRHYSPVWTGGTYFVFVIFGSM-AAFFVAFSIK-R---------LGPA--LLLCFSLMA-FDAGSIMF-----SVL----------------------------PV--E------QSYW-KLNFAMQAILCFGMDLSFP-ASSIILSDGLP-MQ------YQGMAGSLVNTVINYSASLCLGMGGTV----EHQI------------------------------------------NKSGND---------------------------LLKGYRAAVYLGVGLASLGVVISVTYMLEN-------LW-------------------------------------------------------NRHRKSEDRSLEA-------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_EC1118_sace_b_1m3_4896g ----------------------------------------------------------------------------------------------------------------------MFSIFKKKTSVQGTDSEIDEKITVKAKDKVVVSTEDEEVTTIVSS----------------------------------------------------------------------------------------------------TKSTQVTNDSPWQDPTYFSSFGKELMFIATCMLAQLLNQAGQTHALCIMNVLSKSFNS-----EANN--QAWLMASFPLAAGSFILISGRLGDI-YGLKKMLIVGYVIVIVWSIISGLSKYSN--SDAFFITSRAFQGVGIAFILPNIMGLVGHVYKVGSFRKNIVISFIGACAPTGG--MFGGLFGGLIVT-----EDPNQWPW-VF---YAFGIATFLSLLMAWYSI-------PNN--------------------------------------------------------------------------------------------------VPTNI--------HG---------------------LSM----DWTGSALAIIGLILFNFVWNQA--------PIV----GWDK------PYIIVLLIISVIF-L-VAFFV--YE-S-------------------K-----YAE-V----------P-LLPRAMT-KNRHMIMILLAVFLGWGSF-GIWTFYYVSFQLNLRHYSPVWTGGTYFVFVIFGSM-AAFFVAFSIK-R---------LGPA--LLLCFSLMA-FDAGSIMF-----SVL----------------------------PV--E------QSYW-KLNFAMQAILCFGMDLSFP-ASSIILSDGLP-MQ------YQGMAGSLVNTVINYSASLCLGMGGTV-E--HQIN-------------------------------------------KSGND---------------------------LLKGYRAAVYLGVGLASLGVVI--SVTYML---E---NL-------------------------------------------------------WNRHRKSEDRSLEA------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_JAY291_sace_c_03767 ----------------------------------------------------------------------------------------------------------------------MFSIFKKKTSVQGTDSEIDEKITVKAKDKVVVSTEDEEVTTIVSS----------------------------------------------------------------------------------------------------TKSTQVTNDSPWQDPTYFSSFGKELMFIATCMLAQLLNQAGQTHALCIMNVLSKSFNS-----EANN--QAWLMASFPLAAGSFILISGRLGDI-YGLKKMLIVGYVIVIVWSIISGLSKYSN--SDAFFITSRAFQGVGIAFILPNIMGLVGHVYKVGSFRKNIVISFIGACAPTGG--MFGGLFGGLIVT-----EDPNQWPW-VF---YAFGIATFLSLLMAWYSI-------PNN--------------------------------------------------------------------------------------------------VPTNI--------HG---------------------LSM----DWTGSALAIIGLILFNFVWNQA--------PIV----GWDK------PYIIVLLIISVIF-L-VAFFV--YE-S-------------------K-----YAE-V----------P-LLPRAMT-KNRHMIMILLAVFLGWGSF-GIWTFYYVSFQLNLRHYSPVWTGGTYFVFVIFGSM-AAFFVAFSIK-R---------LGPA--LLLCFSLMA-FDAGSIMF-----SVL----------------------------PV--E------QSYW-KLNFAMQAILCFGMDLSFP-ASSIILSDGLP-MQ------YQGMAGSLVNTVINYSASLCLGMGGTV-E--HQIN-------------------------------------------KSGND---------------------------LLKGYRAAVYLGVGLASLGVVI--SVTYML---E---NL-------------------------------------------------------WNRHRKSEDRSLEA------------------------------------------------------------------------------------- 'Saccharomyces cerevisiae RM11-1A sace d 02175' ----------------------------------------------------------------------------------------------------------------------MCFIFKKKTSVQGTDSEIDEKITVKAKDKVVVSTEDEEVTTIVSS----------------------------------------------------------------------------------------------------TKSTQVTNDSPWQDPTYFSSFGKELMFIATCMLAQLLNQAGQTHALCIMNVLSKSFNS-----EANN--QAWLMASFPLAAGSFILISGRLGDI-YGLKKMLIVGYVIVIVWSIISGLSKYSN--SDAFFITSRAFQGVGIAFILPNIMGLVGHVYKVGSFRKNIVISFIGACAPTGG--MFGGLFGGLIVT-----EDPNQWPW-VF---YAFGIATFLSLLMAWYSI-------PNN--------------------------------------------------------------------------------------------------VPTNI--------HG---------------------LSM----DWTGSALAIIGLILFNFVWNQA--------PIV----GWDK------PYIIVLLIISVIF-L-VAFFV--YE-S-------------------K-----YAE-V----------P-LLPRAMT-KNRHMIMILLAVFLGWGSF-GIWTFYYVSFQLNLRHYSPVWTGGTYFVFVIFGSM-AAFFVAFSIK-R---------LGPA--LLLCFSLMA-FDAGSIMF-----SVL----------------------------PV--E------QSYW-KLNFAMQAILCFGMDLSFP-ASSIILSDGLP-MQ------YQGMAGSLVNTVINYSASLCLGMGGTV-E--HQIN-------------------------------------------KSGND---------------------------LLKGYRAAVYLGVGLASLGVVI--SVTYML---E---NL-------------------------------------------------------WNRHRKSEDRSLEA------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_YJM789_sace_e_4461 ----------------------------------------------------------------------------------------------------------------------MFSIFKKKTSVQGTDSEIDEKITVKAKDKVVVSTEDEEVTTIVSS----------------------------------------------------------------------------------------------------TKSTQVTNDSPWQDPTYFSSFGKELMFIATCMLAQLLNQAGQTHALCIMNVLSKSFNS-----EANN--QAWLMASFPLAAGSFILISGRLGDI-YGLKKMLIVGYVIVIVWSIISGLSKYSN--SDAFFITSRAFQGVGIAFILPNIMGLVGHVYKVGSFRKNIVISFIGACAPTGG--MFGGLFGGLIVT-----EDPNQWPW-VF---YAFGIATFLSLLMAWYSI-------PNN--------------------------------------------------------------------------------------------------VPTNI--------HG---------------------LSM----DWTGSALAIIGLILFNFVWNQA--------PIV----GWDK------PYIIVLLIISVIF-L-VAFFV--YE-S-------------------K-----YAE-V----------P-LLPRAMT-KNRHMIMILLAVFLGWGSF-GIWTFYYVSFQLNLRHYSPVWTGGTYFVFVIFGSM-AAFFVAFSIK-R---------LGPA--LLLCFSLMA-FDAGSIMF-----SVL----------------------------PV--E------QSYW-KLNFAMQAILCFGMDLSFP-ASSIILSDGLP-MQ------YQGMAGSLVNTVINYSASLCLGMGGTV-E--HQIN-------------------------------------------KSGND---------------------------LLKGYRAAVYLGVGLASLGVVI--SVTYML---E---NL-------------------------------------------------------WNRHRKSEDRSLEA------------------------------------------------------------------------------------- 'Saccharomyces paradoxus NRRL Y-17217 sapa c419 17887' ----------------------------------------------------------------------------------------------------------------------MFPIFKKKTSVQGTDSEINEKTTMKTNDKVIVSTEDEEVTTIASS----------------------------------------------------------------------------------------------------IKSNQVTNDSPWQDPTYFGSFGKELMFIATCMLAQLLNQAGQTHALCIMNVLSKSFNS-----EANN--QAWLMASFPLAAGSFILISGRLGDI-YGLKKMLMVGYVIVIVWSIISGLSKYSN--SDAFFITSRAFQGVGIAFILPNIMGLVGHVYKVGSFRKNIVISFIGACAPTGG--MFGGLFGGLIVT-----EDPDQWPW-VF---YAFGIATFLSLLMAWYSI-------PNN--------------------------------------------------------------------------------------------------VPTNI--------HG---------------------LSM----DWTGSALAIVGLILFNFVWNQA--------PIV----GWDK------AYIIVLLIISVIF-L-VAFFV--YE-S-------------------K-----YAE-V----------P-LLPREMT-KNRHMIMILLAVFLGWGSF-GIWTFYYVSFQLNLRHYSPVWTGGTYFVFVIFGSM-AAFFVAFSIK-R---------LGPA--LLLCFSLIA-FDAGSIMF-----SVL----------------------------PV--E------QSYW-KLNFAMQAILCFGMDLSFP-ASSIILSDGLP-MQ------YQGMAGSLVNTVINYSASLCLGMGGTV----EHQI------------------------------------------NKSGND---------------------------LLKGYRAAIYLGIGLASLGFLISVTYMLEN-------LW-------------------------------------------------------NQRRKCEKKSLEA-------------------------------------------------------------------------------------- Candida_guilliermondii_ATCC_6260_cagu_04492 -------------------------------------------------------------------------------------------------------------------------------------------------------------MDIEAR----------------------------------------------------------------------------------------------------EVDPLIPNSDTHRRTGKFSSAPNFTCIEIALLLNVFLSGFDATVTASTYTTIGNEFG------TARF--ASWITTSYLITSTAFQPLYGSLSDV-VGRRVCVFFALSFFLVGCFGCSVAP-----TFLFLNIMRGITGIGGGGLLTLATIIHSDIIYPE--KRGLFQAFQNLTLGFGS--ICGASLGGYISS--I--V---GWRF-CF---LLQCPLTAFSILVAYSYV-------NNQ-----------R--------------------------------------------------------------------------------------GFQEL--------HI------SKLL-----------TKV----DLKGAVLIFLAISSQLLVLTLGG-------NEL----AWTD------YRLIGLGFLSLLL-T-LVFID--AE-N-------------------K-----TTA-V----------P-IIKLSDY-KDLFSISQLAINFLIGLAA-FAYLFTLPLLFQLEFGDTASAAGFRLMLPALSTPI-GGLLAGLLME-R---------YKLL-RSLAISGIFT-MLVGNSLI-----LTV--------------------------------T------NSTRKWVLNFLLMPANLGQGLAYP-SSLFTFIFAHG-IE------HQASSTATVYVLRSIGGVWGVTGSSLI-I--SKLT-RARISRHLKD----------------YGLKHREVKTIVKR-ISQSIA------SIQ----DLPPDIKSLVLKD-YVSAIKVSF-----LSSCSLLL--GTVRQE-------KA-----TDA-----------------------------------------------TRLNYGIGSCMRAVTYLN--------------------------------------------------------------------------------- 'Saccharomyces castelli NRRL Y-12630 saca 692.14' -----------------------------------------------------------------------------------------------------------------------MFRIFNRKSHRSEEIMESAASSITEETSIIKHGDIEEIEKDVIS----------------------------------------------------------------------------------------------------QTETPQLEHSKWQNPDYFQNQWQEYLFIFSCMMSQLLNQAATPQTLSIMNIITDSFNS-----EGGK--ETWLIASFPLVSGSFILISGRIGDI-YGLKKTLVGGYIFFIIWSIISGLTKYSH--SDTFFIVSRAFQGLSIAFILPNVMGIVGNIYKPDSNRKNIVISMIGASAPIGA--FFGSLFAGLIGT-----EDPDQWPW-AF---YAFAIASAFNLAISIYSI-------PNS--------------------------------------------------------------------------------------------------VPTNV--------HG---------------------FAM----DWIGSVLAVIGLILLNFVWNQG--------PIV----GWQT------AYIIALLVVSVFF-L-ALFFT--YE-V-------------------K-----YAE-S----------P-LLPVEVT-KNRHIIMILAALFLGWGSF-GIFSFYYFSFLLNLRHYSALWAGTTYFMFAIWGTV-AAVIVGAFIK-----------KISA-AFILFMSMVA-FNIGIIML-----SVT----------------------------PV--D------QTYF-RMNLGTMIILSFGMDMSFP-AAAIILSDGLT-MQ------YQGMAGSLANTMVNYSMSLCLGMGTTV----ERQI------------------------------------------NKSGND---------------------------LLKGYRGAEYLGIGLAGLGIII-TAIYLGE-------IL-------------------------------------------------------WGKRKQHLAANVVPDLS---------------------------------------------------------------------------------- Saccharomyces_cerevisiae_S288C_sace0m00462g -----------------------------------------------------------------------------------------------------------------------MGNQSLVVLTESKGEYENETELPVKKSSRDNNIGESLTATAFTQ----------------------------------------------------------------------------------------------------SEDEMVDSNQKWQNPNYFKYAWQEYLFIFTCMISQLLNQAGTTQTLSIMNILSDSFGS-----EGNS--KSWLMASFPLVSGSFILISGRLGDI-YGLKKMLLVGYVLVIIWSLICGITKYSG--SDTFFIISRAFQGLGIAFVLPNVLGIIGNIYVGGTFRKNIVISFVGAMAPIGA--TLGCLFAGLIGT-----EDPKQWPW-AF---YAYSIAAFINFVLSIYAI-------PST--------------------------------------------------------------------------------------------------IPTNI--------HH---------------------FSM----DWIGSVLGVIGLILLNFVWNQA--------PIS----GWNQ------AYIIVILIISVIF-L-VVFII--YE-I-------------------R-----FAK-T----------P-LLPRAVI-KDRHMIQIMLALFFGWGSF-GIFTFYYFQFQLNIRQYTALWAGGTYFMFLIWGII-AALLVGFTIK-----------NVSP-SVFLFFSMVA-FNVGSIMA-----SVT----------------------------PV--H------ETYF-RTQLGTMIILSFGMDLSFP-ASSIIFSDNLP-ME------YQGMAGSLVNTVVNYSMSLCLGMGATV----ETQV------------------------------------------NSDGKH---------------------------LLKGYRGAQYLGIGLASLACMI-SGLYMVE-------SF-------------------------------------------------------IKGRRARAAAEYDCTVA---------------------------------------------------------------------------------- Saccharomyces_cerevisiae_EC1118_sace_b_1m3_0188g -----------------------------------------------------------------------------------------------------------------------MGNQSLVVLTESKGEYENETELPVKKSSRDNNIGESLTATAFTQ----------------------------------------------------------------------------------------------------SEDEMVDSNQKWQNPNYFKYAWQEYLFIFTCMISQLLNQAGTTQTLSIMNILSDSFGS-----EGNS--KSWLMASFPLVSGSFILISGRLGDI-YGLKKMLLVGYVLVIIWSLICGITKYSG--SDTFFIISRAFQGLGIAFVLPNVLGIIGNIYVGGTFRKNIVISFVGAMAPIGA--TLGCLFAGLIGT-----EDPKQWPW-AF---YAYSIAAFINFVLSIYAI-------PST--------------------------------------------------------------------------------------------------IPTNI--------HH---------------------FSM----DWIGSVLGVIGLILLNFVWNQA--------PIS----GWNQ------AYIIVILIISVIF-L-VVFII--YE-I-------------------R-----FAK-T----------P-LLPRAVI-KDRHMIQIMLALFFGWGSF-GIFTFYYFQFQLNIRQYTALWAGGTYFMFLIWGII-AALLVGFTIK-----------NVSP-SVFLFFSMVA-FNVGSIMA-----SVT----------------------------PV--H------ETYF-RTQLGTMIILSFGMDLSFP-ASSIIFSDNLP-ME------YQGMAGSLVNTVVNYSMSLCLGMGATV----ETQV------------------------------------------NSDGKH---------------------------LLKGYRGAQYLGIGLASLACMI-SGLYMVE-------SF-------------------------------------------------------IKGRRARAAAEYDCTVA---------------------------------------------------------------------------------- Saccharomyces_cerevisiae_JAY291_sace_c_04366 -----------------------------------------------------------------------------------------------------------------------MGNQSLVVLTESKGEYENETELPVKKSSRDNNIGESLTATAFTQ----------------------------------------------------------------------------------------------------SEDEMVDSNQKWQNPNYFKYAWQEYLFIFTCMISQLLNQAGTTQTLSIMNILSDSFGS-----EGNS--KSWLMASFPLVSGSFILISGRLGDI-YGLKKMLLVGYVLVIIWSLICGITKYSG--SDTFFIISRAFQGLGIAFVLPNVLGIIGNIYVGGTFRKNIVISFVGAMAPIGA--TLGCLFAGLIGT-----EDPKQWPW-AF---YAYSIAAFINFVLSIYAI-------PST--------------------------------------------------------------------------------------------------IPTNI--------HH---------------------FSM----DWIGSVLGVIGLILLNFVWNQA--------PIS----GWNQ------AYIIVILIISVIF-L-VVFII--YE-I-------------------R-----FAK-T----------P-LLPRAVI-KDRHMIQIMLALFFGWGSF-GIFTFYYFQFQLNIRQYTALWAGGTYFMFLIWGII-AALLVGFTIK-----------NVSP-SVFLFFSMVA-FNVGSIMA-----SVT----------------------------PV--H------ETYF-RTQLGTMIILSFGMDLSFP-ASSIIFSDNLP-ME------YQGMAGSLVNTVVNYSMSLCLGMGATV----ETQV------------------------------------------NSDGKH---------------------------LLKGYRGAQYLGIGLASLACMI-SGLYMVE-------SF-------------------------------------------------------IKGRRARAAAEYDCTVA---------------------------------------------------------------------------------- 'Saccharomyces cerevisiae RM11-1A sace d 01783' -----------------------------------------------------------------------------------------------------------------------MGNQSLVVLTESKGEYENETELPVKKSSRDNNIGESLTATAFTQ----------------------------------------------------------------------------------------------------SEDEMVDSNQKWQNPNYFKYAWQEYLFIFTCMISQLLNQAGTTQTLSIMNILSDSFGS-----EGNS--KSWLMASFPLVSGSFILISGRLGDI-YGLKKMLLVGYVLVIIWSLICGITKYSG--SDTFFIISRAFQGLGIAFVLPNVLGIIGNIYVGGTFRKNIVISFVGAMAPIGA--TLGCLFAGLIGT-----EDPKQWPW-AF---YAYSIAAFINFVLSIYAI-------PST--------------------------------------------------------------------------------------------------IPTNI--------HH---------------------FSM----DWIGSVLGVIGLILLNFVWNQA--------PIS----GWNQ------AYIIVILIISVIF-L-VVFII--YE-I-------------------R-----FAK-T----------P-LLPRAVI-KDRHMIQIMLALFFGWGSF-GIFTFYYFQFQLNIRQYTALWAGGTYFMFLIWGII-AALLVGFTIK-----------NVSP-SVFLFFSMVA-FNVGSIMA-----SVT----------------------------PV--H------ETYF-RTQLGTMIILSFGMDLSFP-ASSIIFSDNLP-ME------YQGMAGSLVNTVVNYSMSLCLGMGATV----ETQV------------------------------------------NSDGKH---------------------------LLKGYRGAQYLGIGLASLACMI-SGLYMVE-------SF-------------------------------------------------------IKGRRARAAAEYDCTVA---------------------------------------------------------------------------------- Saccharomyces_cerevisiae_YJM789_sace_e_4060 -----------------------------------------------------------------------------------------------------------------------MGNQSLVVLTESKGEYENETELPVKKSSRDNNIGESLTATAFTQ----------------------------------------------------------------------------------------------------SEDEMVDSNQKWQNPNYFKYAWQEYLFIFTCMISQLLNQAGTTQTLSIMNILSDSFGS-----EGNS--KSWLMASFPLVSGSFILISGRLGDI-YGLKKMLLVGYVLVIIWSLICGITKYSG--SDTFFIISRAFQGLGIAFVLPNVLGIIGNIYVGGTFRKNIVISFVGAMAPIGA--TLGCLFAGLIGT-----EDPKQWPW-AF---YAYSIAAFINFVLSIYAI-------PST--------------------------------------------------------------------------------------------------IPTNI--------HH---------------------FSM----DWIGSVLGVIGLILLNFVWNQA--------PIS----GWNQ------AYIIVILIISVIF-L-VVFII--YE-I-------------------R-----FAK-T----------P-LLPRAVI-KDRHMIQIMLALFFGWGSF-GIFTFYYFQFQLNIRQYTALWAGGTYFMFLIWGII-AALLVGFTIK-----------NVSP-SVFLFFSMVA-FNVGSIMA-----SVT----------------------------PV--H------ETYF-RTQLGTMIILSFGMDLSFP-ASSIIFSDNLP-ME------YQGMAGSLVNTVVNYSMSLCLGMGATV----ETQV------------------------------------------NSDGKH---------------------------LLKGYRGAQYLGIGLASLACMI-SGLYMVE-------SF-------------------------------------------------------IKGRRARAAAEYDCTVA---------------------------------------------------------------------------------- 'Candida tropicalis MYA-3404 catr 03278' ---------------------------------------------------------------------------------------------------------------------------------MKEEMAESVNSNEVNDFEIEQGINQEIFDLQRHE----------------------------------------------------------------------------------------------------TTASIITISLLPEPNHTEISKFREILFMSFMCLSQLLTQAGVAQTMNTQFHIAETFGVQD---NPGE--MSWFASSYSMIVGTFILISGRLGDM-YGYKLLYVIGYLWFGVFSLMCGFSGLTK--SNVFFTTMRGLQGMGPAIMMPNTQALIGSYYPES-LKKNICLALFGAIAPTGF--IAGSLFSGMFAV--V--S---SWKW-TF---WTCGIISIFFGVSAILVI-------PKK--------------------------------------------------------------------------------------------------IGIKS--------DG--------KF------------------DYWGSIFGVSGLVLINFALNQG--------PNV----GWNV------PYVYALLIVGVLS-M-VVFFF--VE---------------------K-----KVD-D----------P-LVPSSV--LKGDTGFILGCIAAGWSCF-GVWLYYMFRWSLIIDGDNAVMSAVKTIPCCPMGLI-AAITGAILLT-K----------VPS-GIVMWLANLA-FLVGILLM-----GLR----------------------------PV--G------QIYW-GQKFVSLIIQPIGMDMSFP-AGCILLSSFLP-RR------QQGIAGSLVSTVVNYSIALGLGFAAAV-E-----------------------------------------YYTG-S-ADNQFD--------S------------------DIKGIRHAFYMGIGLAGLGLLI--STRFAY---S---QL------RN------RK------------------------KQSQ-----------ESSELSNSSDPVEMKRQSSSS------------------------------------------------------------------------------ 'Saccharomyces bayanus 623-6C saba a 671.27' ----------------------------------------------------------------------------------------------------------------------MYPVIEEKVNVQSKDSPVIDKISMKAEDKVVVSSEDEDVTTVASS----------------------------------------------------------------------------------------------------NKSTQVSNDSPWQDPTYFSSFGRELMFIVTCMLAQLLNQAGQTHALTIMNVLSKSFNS-----ESDK--QAWLMASFPLVAGSFILISGRLGDI-YGLKKMLMIGYVTIIVWSLICGLSKYSN--NDAFFITCRAFQGLGIAFILPNVMGLVGHVYKVGSTRKNLVISFIGACAPAGG--MFGGLFGGLIVN-----EDSEQWPW-VF---YAFAIAFFLNMILAWYSI-------PNN--------------------------------------------------------------------------------------------------IPTNV--------HG---------------------FSM----DWTGSVLAVIGLILFNFVWNQA--------PTA----GWGT------AYIIALLIISVFF-L-VAFFV--YE-V-------------------K-----YAK-V----------P-LLPHAVT-KNRHMIMILLAVFLGWGSF-GIWTFYYMSFQLNLRHYSPVWTGGTYFVFVIFGTI-AAFMVALSIK-R---------VGPA--FLLCFALVA-FDVGSIMF-----SVL----------------------------PV--K------QSFW-KLNFGMQAILCFGMDLSFP-ASSIILSDGLP-ME------YQGMAGSLVNTVINYSASLCLGMGATV----EHQI------------------------------------------NKNGKD---------------------------LLKGYRGAIYLGVGLASLGVLISFTYMLET-------FW-------------------------------------------------------NNRRDRQKDSVITEMS----------------------------------------------------------------------------------- Saccharomyces_bayanus_MCYC_623_saba_b_c753_19471 ----------------------------------------------------------------------------------------------------------------------MYPVIEEKVNVQSKDSPVIDKISMKAEDKVVVSSEDEDVTTVASS----------------------------------------------------------------------------------------------------NKSTQVSNDSPWQDPTYFSSFGRELMFIVTCMLAQLLNQAGQTHALTIMNVLSKSFNS-----ESDK--QAWLMASFPLVAGSFILISGRLGDI-YGLKKMLMIGYVTIIVWSLICGLSKYSN--NDAFFITCRAFQGLGIAFILPNVMGLVGHVYKVGSTRKNLVISFIGACAPAGG--MFGGLFGGLIVN-----EDSEQWPW-VF---YAFAIAFFLNMILAWYSI-------PNN--------------------------------------------------------------------------------------------------IPTNV--------HG---------------------FSM----DWTGSVLAVIGLILFNFVWNQA--------PTA----GWGT------AYIIALLIISVFF-L-VAFFV--YE-V-------------------K-----YAK-V----------P-LLPHAVT-KNRHMIMILLAVFLGWGSF-GIWTFYYMSFQLNLRHYSPVWTGGTYFVFVIFGTI-AAFMVALSIK-R---------VGPA--FLLCFALVA-FDVGSIMF-----SVL----------------------------PV--K------QSFW-KLNFGMQAILCFGMDLSFP-ASSIILSDGLP-ME------YQGMAGSLVNTVINYSASLCLGMGATV----EHQI------------------------------------------NKNGKD---------------------------LLKGYRGAIYLGVGLASLGVLISFTYMLET-------FW-------------------------------------------------------NNRRDRQKDSVITEMS----------------------------------------------------------------------------------- Saccharomyces_cerevisiae_S288C_sace0p10472g ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKSTLSLTLCVISLLLTLFLAALDIVIVVTLYDTIGIKFH------DFGN--IGWLVTGYALSNAVFMLLWGRLAEI-LGTKECLMISVIVFEIGSLISALSN-----SMATLISGRVVAGFGGSGIESLAFVVGTSIVREN--HRGIMITALAISYVIAE--GVGPFIGGAFNE--H--L---SWRW-CF---YINLPIGAFAFIILAFCN-------TSG----------EP-------------------------------------HQKMWLPSKIKKIMNYDYGELLKASF-----------------------WKNTF--------EV--------LV-----------FKL----DMVGIILSSAGFTLLMLGLSFGG-------NNF----PWNS------GIIICFFTVGPIL-L-LLFCA--YD-FHFLSLSGLHYD--------N-----KRI-K----------P-LLTWNIA-SNCGIFTSSITGFLSCFAY-ELQSAYLVQLYQLVFKKKPTLASIHLWELSIPAMI-ATMAIAYLNS-K---------YGII-KPAIVFGVLC-GIVGSGLF-----TLI--------------------------------N------GEL--SQSIGYSILPGIAFGSIFQ-ATLLSSQVQIT-SDDPDFQNKFIEVTAFNSFAKSLGFAFGGNMGAMI-F--TASL-KNQ----MRS-----SQLNIPQFT--------SVETLLAY-STEHYD-------------GPQSSLSKFINTA-----IHDVFYCALGCYALSFFF--GIFTSS---K----------KTT-----------------------------------------------ISAKKQQ-------------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_EC1118_sace_b_1p2_5457g ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKSTLSLTLCVISLLLTLFLAALDIVIVVTLYDTIGIKFH------DFGN--IGWLVTGYALSNAVFMLLWGRLAEI-LGTKECLMISVIVFEIGSLISALSN-----SMATLISGRVVAGFGGSGIESLAFVVGTSIVREN--HRGIMITALAISYVIAE--GVGPFIGGAFNE--H--L---SWRW-CF---YINLPIGAFAFIILAFCN-------TSG----------EP-------------------------------------HQKMWLPSKIKKIMNYDYGELLKASF-----------------------WKNTF--------EV--------LV-----------FKL----DMVGIILSSAGFTLLMLGLSFGG-------NNF----PWNS------GIIICFFTVGPIL-L-LLFCA--YD-FHFLSLSGLHYD--------N-----KRI-K----------P-LLTWNIA-SNCGIFTSSITGFLSCFAY-ELQSAYLVQLYQLVFKKKPTLASIHLWELSIPAMI-ATMAIAYLNS-K---------YGII-KPAIVFGVLC-GIVGSGLF-----TLI--------------------------------N------GEL--SQSIGYSILPGIAFGSIFQ-ATLLSSQVQIT-SDDPDFQNKFIEVTAFNSFAKSLGFAFGGNMGAMI-F--TASL-KNQ----MRS---------SQLNI----PQFTSVETLLAY-STEHYD-------------GPQSSLSKFINTA-----IHDVFYCALGCYALSFFF--GIFTSS---K---KT-----TIS------AK---------------------------------------KQQ------------------------------------------------------------------------------------------------ Saccharomyces_cerevisiae_JAY291_sace_c_02068 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKSTLSLTLCVISLLLTLFLAALDIVIVVTLYDTIGIKFH------DFGN--IGWLVTGYALSNAVFMLLWGRLAEI-LGTKECLMISVIVFEIGSLISALSN-----SMATLISGRVVAGFGGSGIESLAFVVGTSIVREN--HRGIMITALAISYVIAE--GVGPFIGGAFNE--H--L---SWRW-CF---YINLPIGAFAFIILAFCN-------TSG----------EP-------------------------------------HQKMWLPSKIKKIMNYDYGELLKASF-----------------------WKNTF--------EV--------LV-----------FKL----DMVGIILSSAGFTLLMLGLSFGG-------NNF----PWNS------GIIICFFTVGPIL-S-LLFCA--YD-FHFLPLLGLHYD--------N-----KRI-K----------P-LLTWNIA-SNCGIFTSSITGFLSCFAY-ELQSAYLVQLYQLVFKKKPTLASIHLWELSIPAMI-ATMAIAYLNS-K---------YGII-KPAIVFGVLC-GIVGSGLF-----TLI--------------------------------N------GEL--SQSIGYSILPGIAFGSIFQ-ATLLSSQVQIT-SDEPDFQNKFIEVTAFNSFAKSLGFAFGGNMGAMI-F--TASL-KNQ----MRS-----SQLNIPQFT--------SVETLLAY-STEHYD-------------GPQSSLSKFINTA-----IHDVFYCALGCYALSFFF--GIFTSS---K----------KTT-----------------------------------------------ISAKKQQ-------------------------------------------------------------------------------------------- 'Saccharomyces cerevisiae RM11-1A sace d 04120' ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKSTLSLTLCVISLLLTLFLAALDIVIVVTLYDTIGIKFH------DFGN--IGWLVTGYALSNAVFMLLWGRLAEI-LGTKECLMISVIVFEIGSLISALSN-----SMATLISGRVVAGFGGSGIESLAFVVGTSIVREN--HRGIMITALAISYVIAE--GVGPFIGGAFNE--H--L---SWRW-CF---YINLPIGAFAFIILAFCN-------TSG----------EP-------------------------------------HQKMWLPSKIKKIMNYDYGELLKASF-----------------------WKNTF--------EV--------LV-----------FKL----DMVGIILSSAGFTLLMLGLSFGG-------NNF----PWNS------GIIICFFTVGPIL-L-LLFCA--YD-FHFLSLSGLHYD--------N-----KRI-K----------P-LLTWNIA-SNCGIFTSSITGFLSCFAY-ELQSAYLVQLYQLVFKKKPTLASIHLWELSIPAMI-ATMAIAYLNS-K---------YGII-KPAIVFGVLC-GIVGSGLF-----TLI--------------------------------N------GEL--SQSIGYSILPGIAFGSIFQ-ATLLSSQVQIT-SDDPDFQNKFIEVTAFNSFAKSLGFAFGGNMGAMI-F--TASL-KNQ----MRS---------SQLNI----PQFTSVETLLAY-STEHYD-------------GPQSSLSKFINTA-----IHDVFYCALGCYALSFFF--GIFTSS---K---KT-----TIS------AK---------------------------------------KQQ------------------------------------------------------------------------------------------------ Saccharomyces_cerevisiae_YJM789_sace_e_5897 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKSTLSLTLCVISLLLTLFLAALDIVIVVTLYDTIGIKFH------DFGN--IGWLVTGYALSNAVFMLLWGRLAEI-LGTKECLMISVIVFEIGSLISALSN-----SMATLISGRVVAGFGGSGIESLAFVVGTSIVREN--HRGIMITALAISYVIAE--GVGPFIGGAFNE--H--L---SWRW-CF---YINLPIGAFAFIILAFCN-------TSG----------EP-------------------------------------HQKMWLPSKIKKIMNYDYGELLKASF-----------------------WKNTF--------EV--------LV-----------FKL----DMVGIILSSAGFTLLMLGLSFGG-------NNF----PWNS------GIIICFFTVGPIL-L-LLFCA--YD-FHFLPLLGLHYD--------N-----KRI-K----------P-LLTWNIA-SNCGIFTSSITGFLSCFAY-ELQSAYLVQLYQLVFKKKPTLASIHLWELSIPAMI-ATMAIAYLNS-K---------YGII-KPAIVFGVLC-GIVGSGLF-----TLI--------------------------------N------GEL--SQSIGYSILPGIAFGSIFQ-ATLLSSQVQIT-SDEPDFQNKFIEVTAFNSFAKSLGFAFGGNMGAMI-F--TASL-KNQ----MRS---------SQLNI----PQFTSVETLLAY-STEHYD-------------GPQSSLSKFINTA-----IHDVFYCALGCYALSFFF--GIFTSS---K---KT-----TIS------AK---------------------------------------KQQ------------------------------------------------------------------------------------------------ Saccharomyces_kudriavzevii_IFO_1802_saku_c1565.3 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNKTLSLTLCIISLLLTLFLAALDIVIVVTLYDTIGIKFH------DFGN--IGWLVTGYALTNAVFMLLWGRLAEI-LGTNECLMISVIIFEVGSLISALSN-----SMGTLISGRLIAGFGGSGIESLAFVVGTSIVQEN--HRGTMITALATSYVIAE--GVGPFIGGAFNE--H--L---SWRW-CF---YINLPIGAFALIILAFCN-------TSG----------ES-----------------------------LPKVSLLSKIKSIMSYKYDEVFKASF-------------------------------WKKAF--------KV--------FV-----------FKL----DMIGVTLSSAGFTLLMLGLSFGG-------NNF----AWNS------STIISLFTVGPIL-L-ILFCA--YD-FHFLPLLGLRYE--------N-----KRT-K----------P-LLTWSIA-SNSGIFTSSVTGFFSCFAY-ELQSAYLVQLYQLVLKRKPTLASIHLWELSIPAII-ATMAIAYLNA-K---------YGII-KPAIVFGVLC-GIVGSGLF-----TLI--------------------------------N------GKS--SQSIGYSILPGLAFGSIFQ-ATLLSSQVQIK-SDDPEFQNKFIEVTAFNSFAKSLGFAFGGNMGAMI-F--TASL-KNQ----MRS-----SHLSLPEFT--------SVETLLAY-NTEHYD-------------GSQSLLSQLINTA-----IHDVFYCALGCYALSFFF--GVFTSS---K----------KTA-----------------------------------------------ISVKKQQ-------------------------------------------------------------------------------------------- Saccharomyces_mikatae_IFO_1815_sami_a_c468_17485 ----------------------------------------------------------------------------------------------------------------------MLPIFKKKMSVQGTDYQIHDKTIMKVDDKVVISTEDEEVTTVTSS----------------------------------------------------------------------------------------------------NESNQVTNDSPWQDPIYFSSFGKELMFIATCMLAQLLNQAGQTHALCIMNVLSKSFNS-----ESNN--QAWLMASFPLAAGSFILISGRLGDI-YGLKKMLLIGYVIIIIWSIISGLSKYSN--SDAFFITCRAFQGLGIAFILPNIMGLVGHVYKVGSLRKNLVISVIGACAPAGG--MFGGVFGGLIVT-----EDPEQWPW-VF---YAFSIATFISLLMAWYSI-------PNN--------------------------------------------------------------------------------------------------VPTNV--------HG---------------------LSM----DWTGSTLAVLGLILFNFVWNQA--------PIA----GWGE------AYIIVLLILSVFF-L-IAFFV--YE-I-------------------K-----YAE-V----------P-LLPHAVT-KNRHMIMILLAVFLGWGSF-GIWTFYYVSFQLNLRHYSPVWTGGTYFVFVIFGSI-AAFFVAFSIK-R---------LGPA--ILLCFALMA-FDAGSIMF-----SVL----------------------------PV--E------QSYW-KLNFAMQAILCFGMDLSFP-ASSIILSDGLP-MQ------YQGMAGSLVNTVINYSASLCLGMGVTV----ERQI------------------------------------------NKSGQN---------------------------LLKGYRAAIYLGIGLASLGLLISVTYMLEN-------FW-----NKH-----------------------------------------------KESEKKRLEAETS-------------------------------------------------------------------------------------- 'Saccharomyces paradoxus NRRL Y-17217 sapa c565 22682' ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKNTLSLTLCVISLLLTLFLAALDIVIVVTLYDTIGIKFH------DFGN--IGWLVTGYALSNAVFMLLWGRLAEI-LGTKECLMISVIIFEIGSLISALSN-----SMATLISGRIVAGFGGSGIESLAFVVGTSIVREN--HRGIMITALAISYVIAE--GVGPFIGGAFNE--H--L---SWRW-CF---YINLPIGAFAFIILAFCN-------TSG----------EP-------------------------------------HQKMWLPSKIKKIMNYNYGELLKVSF-----------------------WKNTF--------EV--------LV-----------FKL----DMIGIILSSAGFTLLMLGLSFGG-------NNF----PWNS------SIIISFFTVGPIL-L-LLFCV--YD-FHFLPLLGLHYD--------D-----KRT-K----------P-LLTWNIA-SNCGIFTSSITGFLSCFAY-ELQSAYLVQLYQLVFKKKPTLASIHLWELSIPAML-ATMAIAYLNA-K---------YGII-KPAIVFGVLC-GIVGSGLF-----TLI--------------------------------N------GEL--SQSIGYSILPGIAFGSIFQ-ATLLSSQVQIT-SDDPDFQNKFIEVTAFNSFAKSLGFAFGGNMGAMI-F--TASL-KNQ----MRS-----SHLNLPQFT--------SVETLLAY-STEHYG-------------GPQSLLSKFINTA-----IHDVFYCALGCYGLSFFF--GIFTSS---K----------KTT-----------------------------------------------ISAKKQQ-------------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_JAY291_sace_c_05667 ----------------------------------------------------------------------------------------------------------------------------------------------------------------MAF----------------------------------------------------------------------------------------------------NKVTLLLKWFGDIRNKCQKSRYQLNVNVGLIFLGCTFDLLNVASMISLIDDLAKTYNI-----SYTT--ASWSLTSYAVTFAGFIACMGRLGDI-VGNSVLFTISCSLFAILSLLCAVMP-----NFPAFAVFRAIQGICAAGLVPCAYALIPILAPKE--KVQTYFSIVSCGFSSTI--GLGLIIGGAFAA--T--KI--GYRG-IF---YLTFAVMSVISIVAFFFTYDVERLNKKP--------------------------------------------------------------------------------------------------EKDQV--------QT--------SV-----------KSL----DFIGSLIFVAGSILIVVGLTEGGE-------------SWNR------PVTYVTLIIGIIL-F-FGFFV--WN-CTYAKIVRGIRCVGI-DTSKY-----FEKVQ----------L-LIPVDVL-FMKNFIPIVLAFALNNACL-FSCLYIIDQYSQYAERDSPLLAGVKLVPLIICMVI-GNALCAFEST-----------KLKP-RVGVALGFFL-ALAGSVIL-----IQL----------------------------HLVKE------DVFW-KIFFSSQALVGFGVAIFYP-YALQIAVGGAP-DQ------SKGIASGVAQTFGQLGIEITFSVMASV-L--------------------------------------GNINEMKGR-TDAVQK---------------------------FRTGFQNCSYFTVAVGALGFLV-TAICIRD---I---HP-----PND--------------------------------DNSDLESS-------IHRTKIEIDQEKSGSEGEA-------------------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0f00440g ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFNTIIKTRDSIRSNFQNISFHRYINLVLIMVSCAFDLINVTAVLSATRDIENTYQI-----EFTT--ASWALTAYAITFAGFIAFLGRVGDI-IGNSVLFVSSCFLFSILSLICAVVN-----NFGTFAVFRALQGIAAAGIVPSGYALIPTLSDEH--EVQSFFAIVSCGFSTSF--GIGFIIGGAFTLTRI------GYKG-IF---YLTFAVMLVISIISYFSI-------GTS-------------------------------------------------ANQKPCTKDS---------------------------------------PKTTK--------WS--------DA-----------LSL----DFIGSFMFISSTILIVVGLTEGGE-------------SWKK------PSAYVTLIVGIAL-F-VLFFI--WN-ICYGVLVKNLKSASNPKVYNY-----FRTIQ----------V-LIPKDVL-MMKNFIPITVAVFANYGCL-FSNLYIVNQYCQYVSKNSPLLAAVKLLPLVVSMLI-PNVVIAIKSD-----------LISP-RKAVVLGFFI-MFIGSIIL--IQLHLI--------------------------------T------DNLYWKIFFCSQSLIAFGAAIFFP-YSLNILIGFAP-DE------YKGIASGVMQTFGQFGVEVTFSVMTSI----------------LGN------------------------INELSGKSGSAGI---------------------------YKTRFQNCTYFTLASSVVGLIS-TAFFVKE-------NK-----PTD--------------------------------------DTGSLSTICEEVARGETKDESSIYQNFV-------------------------------------------------------------------------------- Saccharomyces_mikatae_IFO_1815_sami_a_c1152_6745 ----------------------------------------------------------------------------------------------------------------------------------------------------------------MAS----------------------------------------------------------------------------------------------------NKIANLTKALQEIRNKCQKSPYQLNVNVGLIFLGCTFDLLNVASMISLIDDLAKKYNI-----SYTT--ASWSLTSYAVTFAGFIACMGRLGDI-VGNSVLFTISCSCFAILSLLCAVMP-----NFPAFAVFRAIQGICAAGLVPCAYALIPILAPKE--KVQKYFSIVSCGFSSTI--GLGLIIGGAFAA--T--KI--GYRG-IF---YLTFAVMSLISVIAFFFT-------YNV------------------------------------------------------ENFDK---------------------------------------KPQKI--------QA------QTSV-----------KSL----DFIGSLIFVAGSILIVVGLTEGGE-------------SWNR------PVTYVTLIIGILL-F-FGFFV--WN-CTYAKIVRGIRFVGI-DTSKY-----FEKVQ----------L-LIPVDVL-FMKNFIPIVLAFALNNACL-FSCLYIIDQYSQYAEKDSPLLAGVKLVPLIICMVV-GNALCAFEST-----------KLKP-RVGVALGFSL-ALAGSIIL-----IQL----------------------------HLIKD------NVFW-KIFFSSQALVGFGVAIFYP-YALQIAVGGAP-DQ------SKGIASGVAQTFGQLGIEITFSVMASV-L--------------------------------------GDINEMKGK-EDAIQN---------------------------FRTGFQNCSYFTVAVGALGFLV-TAICIRD---I---HT-----PND--------------------------------DISDLESS-------IHRTKIEMDQEKDGPEGKA-------------------------------------------------------------------------------- Saccharomyces_mikatae_IFO_1815_sami_a_c208_6715 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNKTLSLTLCITSLLLTLFLAALDIVIVVTLYDTIGIKFH------DFGN--IGWLVTGYALSNAVFMLLWGRLAEI-LGTTECLMISVVIFEIGSLISALSN-----TMGTLIGGRVIAGFGGSGIESLAFVVGTSIVQEN--YRGIMITALAVSYVIAE--GVGPFIGGAFNE--H--L---SWRW-CF---YINLPIGAFAFISLAFCCASGGKWLSKK---------------------------------------------WLLSKINSITSYKYYEIFKASF-------------------------------WKKVF--------QI--------LV-----------FKL----DMIGIILSSAGFTLLMLGLSFGG-------NNF----AWNS------SIIISFFTLGPIL-L-ILFCA--YD-FHILPLLGVHYKS-------K-----YAR------------P-LLTWKIA-SNAGIFTSSITGFFSCFAY-ELQSAYLVQLYQLVLKRNSMLASIHLWELSIPAMI-TTMATAYLNA-K---------YGII-KPAIVFGVLC-GIVGSGIF-----TLI--------------------------------N------GEI--SQSIGYSLLPGIAFGSIFQ-ATLLSSQVQIT-PDDPDFQNKFIEVTAFNSFAKSLGFSFGGNIGAMI-F--TASL-KNQ----LRS-----SNANLPQFT--------SIETLLAY-RTENYD-------------GPQSLLSQFINTA-----IHNVFYCALGCYALSFFF--GVFTSS---K----------KTS-----------------------------------------------VSVKKQQ-------------------------------------------------------------------------------------------- Saccharomyces_mikatae_IFO_1815_sami_b_c2021.3 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNKTLSLTLCITSLLLTLFLAALDIVIVVTLYDTIGIKFH------DFGN--IGWLVTGYALSNAVFMLLWGRLAEI-LGTTECLMISVVIFEIGSLISALSN-----TMGTLIGGRVIAGFGGSGIESLAFVVGTSIVQEN--YRGIMITALAVSYVIAE--GVGPFIGGAFNE--H--L---SWRW-CF---YINLPIGAFAFISLAFCC-------ASG----------GK------------------W------------------LSKKWLLSKINSITSYKYYEIFKASF-----------------------WKKVF--------QI--------LV-----------FKL----DMIGIILSSAGFTLLMLGLSFGG-------NNF----AWNS------SIIISFFTLGPIL-L-ILFCA--YD-FHILPLLGVHYKS-------K-----YAR------------P-LLTWKIA-SNAGIFTSSITGFFSCFAY-ELQSAYLVQLYQLVLKRNSMLASIHLWELSIPAMI-TTMATAYLNA-K---------YGII-KPAIVFGVLC-GIVGSGIF-----TLI--------------------------------N------GEI--SQSIGYSLLPGIAFGSIFQ-ATLLSSQVQIT-PDDPDFQNKFIEVTAFNSFAKSLGFSFGGNIGAMI-F--TASL-KNQ----LRS---------SNANL----PQFTSIETLLAY-RTENYD-------------GPQSLLSQFINTA-----IHNVFYCALGCYALSFFF--GVFTSS---K---KT-----SVS------VK---------------------------------------KQQ------------------------------------------------------------------------------------------------ 'Saccharomyces paradoxus NRRL Y-17217 sapa c345 7127' ----------------------------------------------------------------------------------------------------------------------------------------------------------------MAP----------------------------------------------------------------------------------------------------NRVTKLLKALEDIRNKCQKSPYQLNVNVGLIFLGCTFDLLNVASMISLIDDLAKTYNI-----SYTT--ASWSLTSYAVTFAGFIACMGRLGDI-VGNSVLFTISCSFFAILSLLCAVMP-----NFPAFAVFRAIQGICAAGLVPCAYALIPILAPKE--KVQTYFSIVSCGFSSTI--GLGLIIGGAFAA------TKIGYRG-IF---YLTFAVVSLISIIAFFFT---YDVERFN---------KKP--------------------------------------------------------------------------------------QNDQV--------RT--------SV-----------KSL----DFIGSLIFVAGSILIVVGLTEGGE-------------SWNR------PVTYVTLIIGIIL-F-FGFFV--WN-CTYAKVVRGIRCVGI-DTSKY-----FEKVQ----------L-LIPVDVL-FMKNFIPIVLAFALNNACL-FSCLYIIDQYSQYAEKDSPLLAGVKLVPLIVCMVI-GNALCAFEST-----------KLKP-RVGVALGFFL-ALAGSVIL--IQLHLV--------------------------------K------EDVFWKIFFSSQALVGFGVAIFYP-YALQIAVGGAP-DQ------SKGIASGVAQTFGQLGIEITFSVMASV----------------LGN-------------------------------INEMRG-------------------KNDAVQK-FRTGFQNCSYFTVAVGALGFLV-TALCIRD---I---RP-----PND---------------------------------------GTSDLESSIHRTKIEIDQEKDETEEKA-------------------------------------------------------------------------------- Saccharomyces_mikatae_IFO_1815_sami_a_c551_15970 --------------------------------------------------------------------------------------------------------------------MSVHVLVESEEKNDDCMEVENEAVFPPKKSSRDNGSEETLRGTAFTN----------------------------------------------------------------------------------------------------FEDEMVECNQKWQNPKYFKYAWQEYLFIFTCMISQLLNQAGTTQTLSIMNILSDSFGS-----EGNS--KSWLMASFPLVSGSFILISGRLGDI-YGLKKMLLVGYVLVIIWSLICGITNYSG--SDTFFIICRAFQGLGIAFVLPNVLGIIGNIYVGGTFRKNIVISFVGAMAPIGA--TLGCLFAGLIGT-----ENPNQWPW-AF---YAFSIASLINFGLSIYAI-------PNN--------------------------------------------------------------------------------------------------IPTNI--------HH---------------------FSM----DWIGSVLGVIGLILLNFVWNQA--------PIS----GWSQ------AYIIVILIISVIF-L-AVFII--YE-M-------------------W-----FAK-S----------P-LLPHAVI-KDYHMIQIMLALFFGWGSF-GIFTFYYFQFQLNIRHYTALWAGGTYFMFLIWGII-AALLVGFTIK-N----------VSP-SVYLFFSMVA-FNVGSIMA-----SVT----------------------------PV--H------ETYF-RTQLGTMIILSFGMDLSFP-ASSIIFSDNLP-ME------YQGMAGSLVNTVVNYSMSLCLGMGATV-E-------TQL--------------------------------------DPDGKH---------------------------LLKGYRGAQYLGIGLASLACMI-SGLYMVE-------SF------IN-----------------------------------------------DHKAKAATENDCATT------------------------------------------------------------------------------------ 'Saccharomyces paradoxus NRRL Y-17217 sapa c443 17778' --------------------------------------------------------------------------------------------------------------------MSKQSLVELTESKDEYLELENEETLPVKKSSRDNGNEETLIATAFTH----------------------------------------------------------------------------------------------------SEDEMVESNQKWQNPNYFKYAWQEYLFIFTCMISQLLNQAGTTQTLSIMNILSDSFGS-----EGNS--KSWLMASFPLVSGSFILISGRLGDI-YGLKKMLLIGYVLVIIWSLICGITKYSG--SDTFFIISRAFQGLGIAFVLPNVLGIIGNIYVGGTFRKNIVISFVGAMAPIGA--TLGCLFAGLIGT-----EDPKQWPW-AF---YAYSIASLINFALSIYAI-------PNA--------------------------------------------------------------------------------------------------IPTNI--------HH---------------------FSM----DWIGSVLGVIGLILLNFVWNQA--------PIS----GWSQ------AYIIVILVISVVF-L-VAFVI--YE-I-------------------R-----FAK-S----------P-LLPRAVI-KDRHMIQIMLALFFGWGSF-GIFTFYYFQFQLNIRHYTALWAGGTYFMFLIWGII-AALLVGFTIK-----------NVSP-SVFLFFSMVA-FNVGSIMA-----SVT----------------------------PV--H------ETYF-RTQLGTMIILSFGMDLSFP-ASSIIFSDNLP-ME------YQGMAGSLVNTVVNYSMSLCLGMGATV----ETQL------------------------------------------NPDGKN---------------------------LLKGYRGAQYLGIGLASLACMISGLYMVES-------FI-----KDH-----------------------------------------------RARAAAEYDCAMT-------------------------------------------------------------------------------------- Pichia_stipitis_CBS_6054_pist_igi16258608 ----------------------------------------------------------------------------------------------------------------------------------------------------------MAAKKEKQE----------------------------------------------------------------------------------------------------IFEESNAGDGTRREDQYIGGYK-LIIVVTSLLISMLLSVMDATIVVTILPQISNKFD------GFEK--INWLTSGFLLAIASLTATWGKLSIV-IGRKLGIVLSIIIFMIGSLVCALAN-----SMDMLIGGRVVAGVGGGGLQSLVLVVLTEILPIE--YRTFGIMLLSITTALGS--VIGPLIGGAFSR--F------DWRW-CF---YINLPVGGLSLLLLVAVF-------NPP-----------A--------------------------------------------------------------------------------------PKGKI--------KD--------KI-----------KMI----DYFGTFLLSSGSVLVLLALSFGSS------YQY----TWNS------AAFISCIVIGVIS-S-VLFCV--WN-Y-------------------N-----YSK-Y----------P-LIPPEIT-EVLSLDATVITATAMFGFF-FANQIYLSVYFQSIKGMDGWHSGLHLLPIIVSSVV-STLIGGMISQ-I---------TGYL-KPISILAGII-GVVGNALL-----YLL----------------------------KV--D------SSL--GKIIGLLILPGISSGLQIQ-STAMLSQVSAP-KTPG----GTILATTLYTFGRTMGGAIGSELATLT-Y--SESL-KHIFKRALKH---------ETNST----VLQDIQEIGFGS-LLENTS------LLA----KLHPVTQEFFKAQ-MMKSIVNVFHMGTGLAALALIA--SVFQSN---L---KV-----PKQ-----------------------------------------------SKGVDEDNDQEENTD------------------------------------------------------------------------------------ Kluyveromyces_thermotolerans_CBS6340_klth0h16214g -------------------------------------------------------------------------------------------------------------------------------------------------------------MANMHT----------------------------------------------------------------------------------------------------TAAPKLSEGIYNLRRRCQNSKYQLIINMALIFLGCTFDLLNVAGVISVIEDLGETYGL-----EYTT--ASWALTSYAITFAGLIAFMGRLGDI-IGNSVLFTISGFFFSLFCLLCAVVT-----NFPAFAVLRALQGIAAAGLVPCGYALIPTLADPE--DVQLFFAVVSCGFSSTI--GIGLIIGGAFAL------TNVGYKG-IF---YLSFAGMLLVSIAAFFFT-------YRI---------EEH----------------------------------------KFAEQD----------------------------------------YEGSI--------HR------PGKV-----------ASL----DFVGSLIFISGSVLIVVGLTEGGE-------------SWKR------PVAYVPFTIGMIF-F-CGFFA--WN-CSYQNLVIFLKKLGC-DTSRY-----LEKVQ----------V-LIPRDVL-FMTNFIPITLGFLCNGGCL-YSNIYIIDQYSQYVDKNSPLLAGVKLVPLIITMVI-GNTICASKSV-----------KLRP-RIGVALGFLS-MVCGSIIL--IQLHLV--------------------------------E------ENLYWKIMFCSQILVGFGAAIFYP-YALKLVVGDAP-SG------AKGIASGVTQTFAQLGIEMTFSVMVSV-L--GNIT---------------------------------------QV-KSRPDS------FER------------------FRDGFQKCTYFTLASGAFGLVL-TTFFVRG---P---RF-----SNG--------------------------------SPKDATAL-------ENGSYSQTESNCEKKEQQY-------------------------------------------------------------------------------- Pichia_stipitis_CBS_6054_pist_igi18293386 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTRKAELLNEQYQSPHLKVCLFVSIFFVAYTYGIESTLRGNIQAYATSSYT------QHSL--LSTVNVIKSVVAAASQPMYARLSDK-FGRLELMLVSIVFYIVGTVIQSQAF-----DINRFAGGSVLYQVGFSGVMIMLQIILADFSNLN--WRLVCSFVPALPFIINT-WVAAEVQASLLAN--H------SWNF-AIGIWAFIFPLSCVPLLLCFIHM-------IWK----------AR-------------------------------------KTDEWQRLKEERTKTP---------------------------------FIQKA--------VE--------LF-----------WEL----DVVGIVLLVCVFGFILVPFTIAGG------VTD----KWKE------ASTLAPLIIGFAL-L-PVFVW--WE-Y-------------------K-----YAK-F----------P-ISPFPLL-KDRGVWSALIIAILIDWVW-YMPNDFMYTVLIVGMRASVKAATRISSLYSFVSVI-VGPLLGLLVV-R---------VRRL-KGFIIFGTIC-WIISLGLL----VHFR----------------------------GS--NDGLESEKYL--DGVIGSLCLLGFGAGFFTY-STQVSIETVTN-HE------YMSIVLSLYLSSYNIGAAIGASVSGAV-W--TNEM-YKAIAANFEE--------------------AGFDSELAALAYGSPFE------FIK--EYTWGTPERIAVVLA-YAKVQRYLCISGLVLCFPLLMA--TFFLRD---H---RL-------------------------------------------------------DSVQSLELDNDH--------------------------------------------------------------------------------------- Yarrowia_lipolytica_CLIB122_yali0f06908g -----------------------------------------------------------------------------------------------------------------MATKGIEVNELALESPAQKSPVSEQDLHSSPVFSEKHIQTHTVDGIELDT----------------------------------------------------------------------------------------------------PPTPPQTHRNVQGRPEVFSSTIVEILCIFLMALATMLESISIGALLVALEDVSAAFKV-----DGGE--LSWTLSAFSLGTGSSLLIMAGIADA-FGRKKVLLAGYGVFALTSLISGFVR-----NDIAFDVLRGLQGLATGAAVPAAIGILGSLYRKPSRRKNYAMACFAAGAPIGF--VCGLVIGGICAE--F--I---GWRG-IL---FFLAIIYAIACIGVFFVV-------PAD--------------------------------------------------------------------------------------------------APLTL--------KE--------AK-----------EKMLVQ-DYGGAFLCLTGFTLFVFAMTQADA------APE----KWNT------PYIIALIVLGGVF-I-GVFVV--YE-C-------------------Y-----VPT-N----------P-IMPPHIW-KCVGFPICMACSALGISTFLGTNQFFMTMYFQKVKGTGPILTTAYFVPMAIAGVC-VNIFAAMTLH-----------IIPG-RILMIMAQC--GFLGASLL----MAFT----------------------------KP---------TTIFWALPFPAEILSVLGADLVYN-VSTLLTINSVG-EE------LQSRAAGIFNTITMLSAAVSLGASSSI-V--STKI----------------------------------------------------------------VDEKTATKQE-FNDGYHYAFWFSVACAGAGLIL--SFFLKL-------GV-------------------------------------------------------TGGDEKLEDEESE-------------------------------------------------------------------------------------- Pichia_pastoris_GS115_pipa_3g03370 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAYHEAAAGDGTTREEQFLKGQKLVLCICSLMLILFLVALDQTIVSTTFTEVGKDFG------SFDK--ISWLVSGYMLASASVVTVYGKLSIV-FGRKYSLLLAIFLFELGSLLCAVSQ-----NMTMLIVARVIAGIGGGGIQSLTTVVASEVVHMN--KRPAIMSLFGIVFAISS--VLGPLVGGVFTT--E--V---TWRW-CY---YINLPVGGFATALLLYAF-------NPP--------------------------------------------------------------------------------------------------RPKFT--------WS--------KI-----------REI----DYIGISSFMAGIVLILLAMSLGG-------INY----PWNS------AAVICCFVLGGLS-L-IVFSI--WN-F-------------------K-----FSS-N----------P-LIPYFVI-KVPGVFVCTLVYFFTFCNF-MTLVIYGTLYFQTILNRSAFQSGIDTLALIIPLMVATLISTGLVQG-----------SKQV-KPVIIIGTIL-GPIGGGLM-----TLL----------------------------DV--D------SPL--SKRIGLFIISGVSLGIQMQ-TVLISAQLAAP-KQAS----GLILTTVVVNFSRSIGGAIGANLANTI-Y--SVTF-SKK----IRP------------------YTENSIIRIPDSVLLNSPE------AIL----SLPENLQELVTEK-LMESLRATFYFGLGCASVAFII--SLFVSN---D---KL-----PKK-----------------------------------------------EKKPEVTETPDQSQDDNKSPSLDKSLEFINVHSKN---------------------------------------------------------------- Kluyveromyces_lactis_CLIB210_klla0c18931g --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPSEKSVTFPKGSLFHQDTLKHLKFICILIACGLDLASVGAMIVLVTDIETRFNV-----SHTQ--SGWALTSYVITFAGFIAFFGRVGDI-VGNGIMMCVFSVIFGIFSLLCAVVP-----NFIAFTVFRAFQGMAGAGIVPCAYALVNKMFQGP--NLQRYFSILSSVISAMA--GVGFIIGGAFGETAL------GYKS-FF---YFLFAASLATAAVICVLI-------GYP----------------------------------------------------ELLLNRH---------------------------------------SYKEK--------FQ--------RV-----------YKL----DVIGCLLFISGSILLVVGLTQGGE-------------SWND------PTAYVPLAVSIVL-L-IIFFM--WN-LGYAVVLKLIKPISTHKGYAY-----MESVN----------L-LIPKNLM-FSHNFIPVLLATFFLFCGF-MVVMYVIANYSATVEGNSMIVASIKIIPMISGLVL-ANGTVAYKQD-----------LFKP-KNALVVGSFI-SILGGAFF--VPIKYV--------------------------------D------DNLFWKLFFMGGFFTGLGGAFFFC-YMITMAIGDAP-DQ------YKALAGGIVQTSGQFGNEVSLSIVISL-L-------GNQ--------------------------------------TTDKAD---------------------------LRDRFQNASYIVITAATISTLV--SLFLVK---G---PL-----ESS------------------------------GDEEKQLSECSESTTSSNSNPENQIETVMVICPDTRDKKEETVDQYLA-------------------------------------------------------------------- Kluyveromyces_lactis_CLIB210_klla0f17776g ------------------------------------------------------------------------------------------------------------------------------------------------------------MTDELQP----------------------------------------------------------------------------------------------------LLSPVPQLPDQAAHDKNVEPLRDVNWIVFALFVGSYLAALDTTIVTTLLPTIASELD------ASNQ--MSWIATSYLLSCSAFQPLYGKLSDV-FGRKPLLIWSNLCFGFGCILCGAPFTK---SLWMLCIGRFIAGVGGGGLNSLSTITTSDIIPLR--QRGVYQGMGNIVFALGC--ASGSLIGAFLQQ--R--I---GWRW-AF---LCQVPLSLLSCSLIMKFL-------NLP----------AG------------------------------------SPGRGLINLSNKKI------------------------------------TTADV--------RE--------HV------------------DFTGSFTLITTMLLLMIILSVLDN------PSHLTYGTW------------ALFIVGLAL---AGYTFVSTE---------------------------LSVHN----------P-MVPIRLLGSNRTVLASSLTNWFFTMST-FVLAYYVPVFWQTVYHLKPWNIGVRTVSNFFGIAI-GSMMTGLYMK-R---------TGKY-KALSNTLNTV-TVAGTLIV-----YLS----------------------------TY--N------TEPKGLLEYFMLFLPGLGYASMLT-ITLLSLIASVD-TS------HQAQVTSIQYAFRAIGSTLGVSFAGLI-Y--QSKL-QTSLLRNIVE-------NKTLNDK----YSTHQLRKWCQT-LLENNS------FDV----SFDPLLESLAKIS-FQGGSRLVLGFAVLASILGLLS--SLFIRE---H---VL-----HTD-----------------------------------------------IQRR----------------------------------------------------------------------------------------------- 'Kluyveromyces waltii NCYC2644 klwa 298-snap.4' ----------------------------------------------------------------------------------------------------------------------------------------------------------------MST----------------------------------------------------------------------------------------------------GKESLCPEQEECETSKAKNNNTRLLLSLFSLGLSMFVTALDVLIVGTIIDTVCKSFG------DYTK--SGWIVTGYSLPNALFSLLWGRISAN-LGPRISIVACIVLFEAGSLISALAR-----SMNMLIAGRVVSGVGGSGLQTLSLVIGCQLVDEK--SRPLVLSLLNCTFAIAS--IIGPFIGGAFTT--H--V---TWRW-CF---YINLPIGGVAILTFLCFY-------NPH----------NE-----------------------------------NLLEEGKKAFKRVLKFKPTSLF-----------------------------SSKAM--------HQ--------LL-----------FGF----DIVSFALFTAGWVLFLLALTFGG-------QSY----SWDS------GVVISFLVVGILL-I-LLSLF--YD---------------------------FKL-FEAMKSQENIRP-LLCWRLM-SQPTIVLSNFSGFFSTVAY-NVQMIYSVQFFQLVYGFTAWKAGLHLIPILVSTVV-FSIMSGVLTK-K---------TGHI-KPLLVFGSAM-GVLGGGLM-----TLL----------------------------NN--T------STK--HTQIGVLILPGVALGFVLP-SALIACHVQLD-KSNSRYGADMLEVTSVNALLKSLGTTLGSILSTMI-F--STSM-YNK----MKS-----RGMSLEEYM--------KLDGIASY-RMSNFD-------------GARSEMGYMLSDS-----IKNTFWMALGSSATAFLC--SLFVSK---S---KV-----NTQ-------------------------------------------------------------------------------------------------------------------------------------------------- Pichia_pastoris_GS115_pipa_3g02865 ------------------------------------------------------------------------------------------------------------------------------MSVKSLETTPLITTT--------VVQSTSDSEVDKDS----------------------------------------------------------------------------------------------------QVQFPIQPVDAVDEDISIWDIPNIFKIELALFTNVFVGSFEGTVTSSTYAIISNEFD------AVNI--GSIITIAYLITSTSFQPLYGSLSDV-LGRRFMSFFAIGVFSVGSLFCGLAR-----DIYSLFLFRAITGIGGAGIISMSTIINSDVIPRK--KRGLFQSFQNIMLGVGS--IIGASLGGLICD--T--I---GWRW-CF---IILLPMSLLSLVLTYLYV-------SNP----------PH--------------------------------------------------------------------------------------HLSGL------------------KL-----------SSV----DIKGSVLLVVGLSLQLIALY-----------------SRSL------RFFLFFLISSSLL-L-FYFIYDLSK-N-------------------D-----PST-I----------K-LIPWETV-NKLPQLLTLNFGFIVGFAN-FANIYVLPLLFQLVLNDSATKAGLRLAIPSFFTSV-GALITGYVMNKN---------VNHL-NWLIKLGFVI-LILGTFLN-----SLI---------------------------------------TPSLKKYVNFIIIPNNIGLGIAYP-ASLFLYIFLFP-NS------LQASSTTTLLLARGVGQVWGMAGASVV-V--AHLV-KFKLWHVLAE-----HKKDLD-------LTDSQIADIIEQ-SSKSLT------YVR----HLPENIAVFVHSS-YKAGLWGAQMVSIAVLVLGLLA--SIFKDF--------------SSK-----------------------------------------------AGKKFVI-------------------------------------------------------------------------------------------- 'Saccharomyces bayanus 623-6C saba a 604.18' ------------------------------------------------------------------------------------------------------------MIVGKEECVIQNPEVKTAGKEEDYLEIENEVALEAEDSSPRNNKEGALTTIVLTN----------------------------------------------------------------------------------------------------SEDEVMKTKQKWQNPNYFKYPWQEYLFIFTCMISQLLNQSGTTQTLSIMNILADSFGS-----DANS--RSWLMASFPLVSGSFILISGRMGDI-FGLKNMLLIGYVMIIIWSLICGLTKYSG--SDTFFIVSRAFQGLGIAFVLPNVLGIIGNVYVGGTFRKNIVISFIGAMAPIGA--TLGCFFAGLIGT-----MNPNQWPW-AF---YAYTITAVINLILSIYAI-------PNN--------------------------------------------------------------------------------------------------IPTNV--------HR---------------------FSM----DWIGSGLGVIGLVLLNLVWNQA--------PIS----GWNQ------AYIIVLLIISVLF-L-VLFGV--YE-I-------------------H-----FAK-S----------P-LLPQAVM-KDRHMIQIMLSLFFGWGSF-GIFTFYYFQFQLNIRHYTPLWAGGSYFMFLIWGII-AALLVGFSIK-----------RVSP-SVFLFFAMVA-FNVGSIMA-----SVT----------------------------PV--H------ETYF-RMQMGTMIILSFGMDLSFP-ASSIIFSDYLP-ME------YQGMAGSLVNTVVNYSMSLCLGMGATV-E------------------------------------------------MQLDPD------GKH------------------ILKGYRGAQYLGIGLASLACII-SGLYMVE---C---YI-----KDH-----------------------------------------------RAKAVAEDKRSMS-------------------------------------------------------------------------------------- Saccharomyces_bayanus_MCYC_623_saba_b_c553_18284 ------------------------------------------------------------------------------------------------------------MIVGKEECVIQNPEVKTAGKEEDYLEIENEVALEAEDSSPRNNKEGALTTIVLTN----------------------------------------------------------------------------------------------------SEDEVMKTKQKWQNPNYFKYPWQEYLFIFTCMISQLLNQSGTTQTLSIMNILADSFGS-----DANS--RSWLMASFPLVSGSFILISGRMGDI-FGLKNMLLIGYVMIIIWSLICGLTKYSG--SDTFFIVSRAFQGLGIAFVLPNVLGIIGNVYVGGTFRKNIVISFIGAMAPIGA--TLGCFFAGLIGT-----MNPNQWPW-AF---YAYTITAVINLILSIYAI-------PNN--------------------------------------------------------------------------------------------------IPTNV--------HR---------------------FSM----DWIGSGLGVIGLVLLNLVWNQA--------PIS----GWNQ------AYIIVLLIISVLF-L-VLFGV--YE-I-------------------H-----FAK-S----------P-LLPQAVM-KDRHMIQIMLSLFFGWGSF-GIFTFYYFQFQLNIRHYTPLWAGGSYFMFLIWGII-AALLVGFSIK-----------RVSP-SVFLFFAMVA-FNVGSIMA-----SVT----------------------------PV--H------ETYF-RMQMGTMIILSFGMDLSFP-ASSIIFSDYLP-ME------YQGMAGSLVNTVVNYSMSLCLGMGATV----EMQL------------------------------------------DPDGKH---------------------------ILKGYRGAQYLGIGLASLACIISGLYMVEC-------YI-----KDH-----------------------------------------------RAKAVAEDKRSMS-------------------------------------------------------------------------------------- Debaryomyces_hansenii_CBS767_deha2f27082g ----------------------------------------------------------------------------------------------------------------------------------MLEIRKVDERS--------SLIDKTETLSGVHI----------------------------------------------------------------------------------------------------ERDGSSQFPNTTTSRSIFSQVDNFLWIELSLFMNVFLSGFDGTVAASTYTTIGNEFG------AMNL--ASWITTSYLITSTAFQPLYGSFSDI-IGRRKCVIFAVICFLVGCFGCSIAK-----SMLMLNLMRAFTGIGGGGLITLSTIINSDIVIPE--KRGLFQAFQNLLLGFGA--ICGASLGGLIAL--T--L---GWRW-CF---IIQIFPALISVFIAFNYI-------PNQ------------------------------------------------------PEFSNE--------------------------------------SISSV--------KN--------IF-----------SRI----DIKGSIILVTALTFQLFVLTLGG-------NVL----AWND------YRLICLGISGFSL-L-LYFLY--VE-C-------------------N-----TTA-N----------P-IIPINKF-KGLFPICLIAFNFLIGLAG-YAYLFILPLLFQIELGDTPSKAGFRLIFPALSTPI-GGVIAGVTMA-R---------FNCL-RLLVYSGSFI-MSIGNFLA-----LLI--------------------------------N------KSTKPWLLNLLLMPANIGQGLAYP-SSLFTFIFAYG-TS------NQATSTSMVYLLRSIGGVWGVAGVSAI-I--QIFT-SSKVSKDLHK---------------LGELNNDEINKILSD-LKKSTD----------AAFTLPDHIKCIVLQD-YESAIKIAQAVSAICCAIAFFL---FLLSD-------VL-------------------------------------------------------KAKTKLVSL------------------------------------------------------------------------------------------ Candida_glabrata_CBS138_cagl0m03003g -----------------------------------------------------------------------------------------------------------------MVLIVTHNMTSEKNNPKSEKTNYDGVVTKSIAFDGCEECSSSDECQSNSD------------QLSVTSKGCIC-----------------------------------------------------------------------------SVDDCHENDSPFQNPEYFETGFKEVMFIISCMVAQLLNQAGQTQSLSTMNVLADYFKS-----NSSK--QPWLMASFPLVSGSFILISGRLGDI-YGLKKALSVGYIIMTLWSIICGLAKYTN--SDAFFIVCRSFQGLGIAFILPNIMGLVGNIYKVGTLRKNIVISCIGCMAPAGA--ALGALFGGLIVT-----EDAEQWPW-VF---YAFGIASFVNMLLALYSI-------PNN--------------------------------------------------------------------------------------------------VPTNL--------NN---------------------LNM----DWIGSLLGVSGLLLLNIVWNQA--------PIV----GWGE------AYIIVLLIISIIL-L-LIFVV--YE-I-------------------K-----YAT-S----------P-LLPPSVL-ENKKILMILAALFFGWGSF-GIWTYYYYAFQLNLRKYTPLWAGGTHFMFVIWGTV-AAFVVALTIK-K---------VGPA--VLLCFSMVA-FDCGSIML-----SVT----------------------------PV--H------QTYW-RMNVGMQIILSFGMDLSFP-ASSIILSDFLP-MQ------YQGMAGSLVNTVVNYSTSLCLGMGNTV----EQQY------------------------------------------NAHGAD---------------------------LLKGYRSALYLAIGLASAGVCVSLVFLVTD-------II-------------------------------------------------------AKRHRKRIESECESC------------------------------------------------------------------------------------ 'Kluyveromyces waltii NCYC2644 klwa 093-snap.33' ----------------------------------------------------------------------------------------------------------------------------------------------------MSSPVQDENTRLLSP----------------------------------------------------------------------------------------------------VDEDNNVHSILEKEYHEQNLNLPKTPILVSLWLGSFLVALDGTIVANVMNRIAEEFQ------ESDK--KQWIATSFLLTNTAFQPLYGKLSDVATGRKGAALVAQFFFCLGLVISCFAQ-----NVTQFAVGRAVCGIGGGGIAAMSSIVVSDICTAK--ERGMYQGYANIVFGSGQ--LLGAPLGGLLIT--T--L---GWRA-IF---AIQVPVTLLCMVLAFRNV--NIKLAHLP----------PP--------------------------------------------------------------------------------------KECFT--------LK--------NL-----------SRL----DLLGSCTLVMSISGLLFLFSTT--------LNK----LWIS-------------IFTAVS-F-GLFVY--NE-Y-------------------Y-----WAT-E----------R-IIPFELL-RGESGVTSALTV-LSSFVM-FGDVFRSPIYLQVVQNVSLARSGLFILFGSIACAG-SSMLTGWLIR-R-----TNMGLVKC-AYLIVLGMIISQLAGTAINAVLIAKLKPNQTSHALTDSITQQTL-----------QP--E------GLLWKIIYVSATVLNTFGYGGVLV-AVLVSIVFTVP-KS------QQATLTGVFYLWRSIGNVLGTSVTLTL-Y--DLTL-KAK----LWK----------Y-------MSSNGLSSSYTQ-LIRDSG------YLR---NQFSGKTLSALLKV-YNASFLWSFGPNIAVGLLAVVL--AYVLVR-------LH-----RTA-----------------------------------------------H-------------------------------------------------------------------------------------------------- Candida_albicans_SC5314_caal_a_19.7554 ---------------------------------------------------------------------------------------------------------------------------------------------------MVSNTLPEHESNTSLH----------------------------------------------------------------------------------------------------DMEKKQLADQLGDIHYKILPIKKLLICLFSLSLALFLSFVDQTSVTIALATIGKDLN------AETT--INWAPTASLLANCICQVLFGRLSDI-FGRKVMLITCLICLSLGELICSFAK-----SGVEFFVFRALTGLSCGGIQSLCMVILSDVVTLK--QRGKYQGILGASVGLGN--SIGPFMMAAFIE--H--N---TWRN-FY---RMMCPINILAFVIIAIFI-------DTK----------------------------------------------------QQTKQLN---------------------------------------QLLSK--------SE--------QF-----------KKL----DYLGMLIGCSGLTLLLVSISSGG-------STY----NWNS------APVISMFVIGGIL-L-ITFLFVEWK---------------------------VPE-L----------P-MIPLNLF-SRFSLGLILGSNFFFGMAY-YGFTFYIAYYYQIVLGLDSIHSAILMLPLVIPQSV-VSAIAGQIIS-Y---------TGHY-IYVIIFGYSL-WTLSCGLT-----LLF----------------------------DS--N------TNY--GVITVVLLLMGTGVACTFQ-PTMVAAQSQAK-KS------ERAVVISCRNVIRSLGGAVGLAVASLI-I--TNSL-LKE----ITK-----QENRQDISS------TSSVPTGYLM-YLKTHV------YSKVDTTQLTADQVLIVRQM-YMQAIRNFFYLTIPLLALCLIS--SLFVKD---K---GL-----QCI-----------------------------------------------DEEPEKEEKELQ--------------------------------------------------------------------------------------- 'Candida albicans WO-1 caal b 02248' ---------------------------------------------------------------------------------------------------------------------------------------------------MVSNTLPEHESNTSLH----------------------------------------------------------------------------------------------------DMEKKQLADQLGDIHYKILPIKKLLICLFSLSLALFLSFVDQTSVTIALATIGKDLN------AETT--INWAPTASLLANCICQVLFGRLSDI-FGRKVMLITCLICLSLGELICSFAK-----SGVEFFVFRALTGLSCGGIQSLCMVILSDVVTLK--QRGKYQGILGASVGLGN--SIGPFMMAAFIE--H--N---TWRN-FY---RMMCPINILAFVIIAIFI-------DTK----------------------------------------------------QQTKQLN---------------------------------------QLLSK--------SE--------QF-----------KKL----DYLGMLIGCSGLTLLLVSISSGG-------STY----NWNS------APVISMFVIGGIL-L-ITFLFVEWK---------------------------VPE-L----------P-MIPLNLF-SRFSLGLILGSNFFFGMAY-YGFTFYIAYYYQIVLGLDSIHSAILMLPLVIPQSV-VSAIAGQIIS-Y---------TGHY-IYVIIFGYSL-WTLSCGLT-----LLF----------------------------DL--N------TNY--GVITVVLLLMGTGVACTFQ-PTMVAAQSQAK-KS------ERAVVISCRNVIRSLGGAVGLAVASLI-I--TNSL-LKEITKQENR----------------QDISSTSSVPTGYLMYLKTHV------YSKVDTTQLTADQVLIVRQM-YMQAIRNFFYLTIPLLALCLIS--SLFVKD---K---GL-----QCI-----------------------------------------------DEEPEKEEKELQ--------------------------------------------------------------------------------------- Candida_dubliniensis_CD36_cadu_34960 ---------------------------------------------------------------------------------------------------------------------------------------------------MTSNNLSEQETNHSIQ----------------------------------------------------------------------------------------------------DIEKKQLADQLGDIHYKILPTKKLLICLFSLSLALFLSFVDQTSVTIALPTIGKDLN------AETT--INWAPTASLLANCICQVLFGRLSDI-FGRKVMLITCLICLSLGELICSFVQ-----TGVEFFVFRALTGLSCGGIQSLCMVILSDVVTLK--QRGKYQGILGASVGIGN--SIGPFMMAAFIE--H--N---NWRN-FY---RMMCPINILAFVIIAIFI-------DTK----------------------------------------------------QQTKQLN---------------------------------------QLLSK--------SE--------QF-----------KKL----DYLGMFIGCSGLTLLLVSISSGG-------STY----NWNS------ALVISMFVIGGVL-L-ITFLFVEWK---------------------------VPE-L----------P-MIPLNLF-SRLSLGLILGSNFFFGMAY-YGFTFYIAYYYQIVLGLDSIHSAILMLPLVIPQSV-VSVIAGQIIS-Y---------TGHY-IYVIIFGYSL-WTLSCGLT-----LLF----------------------------DL--T------TSY--GVITVVLLLMGTGVACTFQ-PTMVAAQSQAK-KS------QRAVVISCRNVIRSLGGAVGLAVASLI-I--TNSL-LKEISKQENH----------------QDISSNVSVPTGYLMYLKTHI------YSKIDTTQLTAAQILIVRKM-YMNSIRNFFYLTIPLLALCLIS--SLFVKD---R---GL-----QCI-----------------------------------------------DEEPERSEKELQ--------------------------------------------------------------------------------------- Saccharomyces_kudriavzevii_IFO_1802_saku_c1455.3 ---------------------------------------------------------------------------------------------------------------------------------------MLKSIRHISPNKNKDGIYGSIEVTETSL----------------------------------------------------------------------------------------------------VEDNADIEDVDKDEDMALSRIPNLWIIEATLFSNVFLSGFDGTVTASTYQTIGNEFN------QMSI--SNWITTAYLITSTSFQPLYGSFSDA-LGRRNCLFFANAAFTIGCLACSLST-----NIYTLSLMRALAGIGGGGLITLSTIVNSDVIPSS--KRGIFQAFQNLLLGFGA--ICGASFGGTIAS--T--I---GWRW-CF---LIQVPISIISSVLMNYYV-------PNQ------------------------------------------------------KEYNHENSN-----------------------------------IFRNS--------KR--------IL-----------TDI----DITGSILIITGLTLQLLYLSLGC-------SGSKL--SWTS------PSVLLLLVGSIAI-L-LLFIS--HE-K-------------------K-----TTA-R----------A-IIPMELV-SSSYSFVVLLISILVGFAS-YAYLFTLPLFFQIVLGDSTAKAGLRLAIPSLFTPV-GSLITGFSMS-K---------YNCL-RSLLYVGVSL-MFLGNFLF-----LFI----------------------------EK--T------SPN--WLISLFLIPANLGQGITFP-TTLFTFIFLFP-KS------DQATATSTLYLFRSIGSVWGVAISAGV-I--QLSF-AKYLRSNLKD-----------------MLDENTIAKLITK-LNANSS------YIE----SLHGEVKNTVIES-FDAATKRAHLMSTLLSLLALIL---CIVKN-------NL-----TKP-----------------------------------------------KTRK----------------------------------------------------------------------------------------------- Saccharomyces_mikatae_IFO_1815_sami_a_c1010_16957 --------------------------------------------------------------------------------------------------------------------------------------------------------MQTLDETSNLL----------------------------------------------------------------------------------------------------PVPEEVETLPLEQKFHEYNLALPKFPILFSLWLGSFLSSLDGTIVANIMNRVAEEFS------ESSR--KQWIATSFLLTNTAFQPLYGKLSDI-TGRKSALLTAHFFFGIGCLLTCFAR-----NVTEFSIARAICGIGAGGLNAIGSIAVSDICTAR--ERGVYQGYANIVFGLGQ--LLGAPLGGVFIE--T--I---GWRA-LF---GVQVPVIMLCSVLAIKNI--NIKLFHVP----------PM--------------------------------------------------------------------------------------KERYT--------LK--------NL-----------SRI----DIFGSLSLVATISGVLFLCS-----------------SHLN------KLYLTLFTIGS---F-IVFIL--VE-R-------------------Y-----YAT-E----------K-ILPLELL--TRSFCLSSAVTVISSFVV-FGEIFRSPIYLQLLQNISVTKTGLFLIFPSVSVAV-GSLVTGWLLR-N-----TKINLAHC-AYQIIFGGMITQLLGLGLG-----YLLLAYLNPDYTIYDMLESITF---------ES--D------SIWWKLIYVFASVLVSFGYACLLV-ATLVSIVFTVE-KS------QQGTMTGVFYLWRSIGNVLGASLTLVS-Y--ENSL-SSM----LWN-----YMFETKRSD------KYHFTKKQYYSLINDTS------YLR--GPNFPTDIFVRILDI-YKKAFLISYLPNIVLAVVGIVL--SFYLVH---H---TY-----KRT------ST------------------------------------------------------------------------------------------------------------------------------------------ 'Saccharomyces bayanus 623-6C saba a 622.18' ----------------------------------------------------------------------------------------------------------------------------------MESSSIKHVTLKKKGDCTYGSIDGSGIVIANNH----------------------------------------------------------------------------------------------------VRDNEEIQNADDDEDIPLSRIPNLWIIEATLFSNVFLAGFDGTITASTYQTIGNEFN------QMSI--SSWITTAYLITSTSFQPLYGSFSDA-LGRRNCLFFANAVFTIGCLACSFST-----NIYMLSFMRALAGIGGGGLITLSTIVNSDVIPSS--KRGIFQAFQNLLLGFGA--ICGASFGGTITS--T--I---GWRW-CF---LIQVPISMIASLLMNYYV-------PNQ------------------------------------------------------KEYDDQKIN-----------------------------------ILLSS--------KK--------IL-----------KDI----DITGSILIIAGLTLQLLYLSLG--------ASF----SWTN------PPVLMLLLASIVI-I-ILFIL--NE---------------------R-----KTTAR----------A-IIPMELV-NSSFSFVVLSISILVGFAS-YAYLFTLPLFFQIVLGDSTAKAGLRLTIPSLFTPV-GSLITGISMS-K---------YDCL-QSLLYIGIFL-MFLGNFLF-----LFI----------------------------EK--T------SPN--WLIGVFLIPANLGQGITFP-TTLFTFIFAFP-KR------DQATATSTLYLFRSIGSVWGVAISAGV-I--QLYF-ARYLRFNLKD-----------------LLDEHTINKIITR-INANSS------YIG----SLHGEVKNTVIKS-FDSATKKAHLMSTLLSLLALIF---CIVKD-------NL-----KKP-----------------------------------------------NSRK----------------------------------------------------------------------------------------------- Saccharomyces_bayanus_MCYC_623_saba_b_c596_2320 ----------------------------------------------------------------------------------------------------------------------------------MESSSIKHVTLKKKGDCTYGSIDGSGIVIANNH----------------------------------------------------------------------------------------------------VRDNEEIQNADDDEDIPLSRIPNLWIIEATLFSNVFLAGFDGTITASTYQTIGNEFN------QMSI--SSWITTAYLITSTSFQPLYGSFSDA-LGRRNCLFFANAVFTIGCLACSFST-----NIYMLSFMRALAGIGGGGLITLSTIVNSDVIPSS--KRGIFQAFQNLLLGFGA--ICGASFGGTITS--T--I---GWRW-CF---LIQVPISMIASLLMNYYV-------PNQ------------------------------------------------------KEYDDQKIN-----------------------------------ILLSS--------KK--------IL-----------KDI----DITGSILIIAGLTLQLLYLSLG--------ASF----SWTN------PPVLMLLLASIVI-I-ILFIL--NE-R-------------------K-----TTA-R----------A-IIPMELV-NSSFSFVVLSISILVGFAS-YAYLFTLPLFFQIVLGDSTAKAGLRLTIPSLFTPV-GSLITGISMS-K---------YDCL-QSLLYIGIFL-MFLGNFLF-----LFI----------------------------EK--T------SPN--WLIGVFLIPANLGQGITFP-TTLFTFIFAFP-KR------DQATATSTLYLFRSIGSVWGVAISAGV-I--QLYF-ARYLRFNLKD-----------------LLDEHTINKIITR-INANSS------YIG----SLHGEVKNTVIKS-FDSATKKAHLMSTLLSLLALIF---CIVKD-------NL-----KKP-----------------------------------------------NSRK----------------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_S288C_sace0m05214g --------------------------------------------------------------------------------------------------------------------------------------------------------MQTLDETSNLL----------------------------------------------------------------------------------------------------PPPEEAEAPPLEQKFHEYNLALPKFPILFSLWLGSFLSSLDSTIVANIMNRVAEEFS------ESSK--KQWIATSFLLTNTAFQPLYGKLSDI-TGRKSALLTAQFFFGLGCLLTCFAR-----NVTEFSIARAICGIGAGGLNAISSIAVSDICTAR--ERGVYQGYANIVFGFGQ--LLGAPLGGVFIE--T--I---GWRA-LF---GIQVPVIMLCSVLAIKNI--NIKLFHVP----------PM--------------------------------------------------------------------------------------KERYT--------LK--------NL-----------SRI----DIFGSLSLVATISGVLFLCSSQLN-----------------------KLYLALFTIGS---F-IVFIL--VE-R-------------------Y-----YAT-E----------K-ILPFELL--TRSFCLSSAVTVISSFVV-FGEIFRSPIYLQLLQNISVTKTGLFLIFPSISVAV-GSLVTGWVLR-N-----TKINLAHC-AYQIIFGGMIMQLLGLGLG-----YFLLSHLNPDYTIYD--MLESITF-------RS--N------SIWWKLIYVFASVLVSFGYACLLV-ATLVSIVFTVE-KS------QQGTMTGVFYLWRSIGNVLGASLTLVS-Y--ENSL-SSM----LWN-----YMFKTK-RD----DEYHFTKKQYYS-LINDSS------YLR--GPNFPTDIFVRILDV-YKKAFLISYIPNIALAAVGIVL--SLYLVK---HTYKRS-----SSS-------------------------------------------------------------------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_EC1118_sace_b_1m3_2575g --------------------------------------------------------------------------------------------------------------------------------------------------------MQTLDETSNLL----------------------------------------------------------------------------------------------------PPPEEAEAPPLEQKFHEYNLALPKFPILFSLWLGSFLSSLDSTIVANIMNRVAEEFS------ESSK--KQWIATSFLLTNTAFQPLYGKLSDI-TGRKSALLTAQFFFGLGCLLTCFAR-----NVTEFSIARAICGIGAGGLNAISSIAVSDICTAR--ERGVYQGYANIVFGFGQ--LLGAPLGGVFIE--T--I---GWRA-LF---GIQVPVIMLCSVLAIKNI--NIKLFHVP----------PM--------------------------------------------------------------------------------------KERYT--------LK--------NL-----------SRI----DIFGSLSLVATISGVLFLCSSQLN-----------------------KLYLALFTIGS---F-IVFIL--VE-R-------------------Y-----YAT-E----------K-ILPFELL--TRSFCLSSAVTVISSFVV-FGEIFRSPIYLQLLQNISVTKTGLFLIFPSISVAV-GSLVTGWVLR-N-----TKINLAHC-AYQIIFGGMIMQLLGLGLG-----YLLLSHLNPDYTIYD--MLESITF-------RS--N------SIWWKLIYVFASVLVSFGYACLLV-ATLVSIVFTVE-KS------QQGTMTGVFYLWRSIGNVLGASLTLVS-Y--ENSL-SSM----LWN-----YMFKTK-RD----DEYHFTKKQYYS-LINDSS------YLR--GPNFPTDIFVRILDV-YKKAFLISYIPNIALAAVGIVL--SLYLVK---HTYKRS-----SSS-------------------------------------------------------------------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_JAY291_sace_c_00976 --------------------------------------------------------------------------------------------------------------------------------------------------------MQTLDETSNLL----------------------------------------------------------------------------------------------------PPPEEAEAPPLEQKFHEYNLALPKFPILFSLWLGSFLSSLDSTIVANIMNRVAEEFS------ESSK--KQWIATSFLLTNTAFQPLYGKLSDI-TGRKSALLTAQFFFGLGCLLTCFAR-----NVTEFSIARAICGIGAGGLNAISSIAVSDICTAR--ERGVYQGYANIVFGFGQ--LLGAPLGGVFIE--T--I---GWRA-LF---GIQVPVIMLCSVLAIKNI--NIKLFHVP----------PM--------------------------------------------------------------------------------------KERYT--------LK--------NL-----------SRI----DIFGSLSLVATISGVLFLCS-----------------SQLN------KLYLALFTIGS---F-IVFIL--VE-R-------------------Y-----YAT-E----------K-ILPFELL--TRSFCLSSAVTVISSFVV-FGEIFRSPIYLQLLQNISVTKTGLFLIFPSISVAV-GSLVTGWVLR-N-----TKINLAHC-AYQIIFGGMIMQLLGLGLG-----YLLLSHLNPDYTIYD--MLESITF-------RS--N------SIWWKLIYVFASVLVSFGYACLLV-ATLVSIVFTVE-KS------QQGTMTGVFYLWRSIGNVLGASLTLVS-Y--ENSL-SSM----LWN-----YMFKTK-RD----DEYHFTKKQYYS-LINDSS------YLR--GPNFPTDIFVRILDV-YKKAFLISYIPNIALAAVGIVL--SLYLVK---HTYKRS-----SSS-------------------------------------------------------------------------------------------------------------------------------------------------- 'Saccharomyces cerevisiae RM11-1A sace d 01978' --------------------------------------------------------------------------------------------------------------------------------------------------------MQTLDETSNLL----------------------------------------------------------------------------------------------------PPPEEAEAPPLEQKFHEYNLALPKFPILFSLWLGSFLSSLDSTIVANIMNRVAEEFS------ESSK--KQWIATSFLLTNTAFQPLYGKLSDI-TGRKSALLTAQFFFGLGCLLTCFAR-----NVTEFSIARAICGIGAGGLNAISSIAVSDICTAR--ERGVYQGYANIVFGFGQ--LLGAPLGGVFIE--T--I---GWRA-LF---GIQVPVIMLCSVLAIKNI--NIKLFHVP----------PM--------------------------------------------------------------------------------------KERYT--------LK--------NL-----------SRI----DIFGSLSLVATISGVLFLCS---------------------SQLNKLYLALFTIGS-----F-IVFIL--VE-R-------------------Y-----YAT-E----------K-ILPFELL--TRSFCLSSAVTVISSFVV-FGEIFRSPIYLQLLQNISVTKTGLFLIFPSISVAV-GSLVTGWVLR-N-----TKINLAHC-AYQIIFGGMIMQLLGLGLG-----YLLLSHLNPDYTIYD--MLESITF-------RS--N------SIWWKLIYVFASVLVSFGYACLLV-ATLVSIVFTVE-KS------QQGTMTGVFYLWRSIGNVLGASLTLVS-Y--ENSL-SSM----LWN-----YMFKTK-RD----DEYHFTKKQYYS-LINDSS------YLR--GPNFPTDIFVRILDV-YKKAFLISYIPNIALAAVGIVL--SLYLVK---HTYKRS-----SSS-------------------------------------------------------------------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_YJM789_sace_e_4257 --------------------------------------------------------------------------------------------------------------------------------------------------------MQTLDETSNLL----------------------------------------------------------------------------------------------------PPPEEAEAPPLEQKFHEYNLALPKFPILFSLWLGSFLSSLDSTIVANIMNRVAEEFS------ESSK--KQWIATSFLLTNTAFQPLYGKLSDI-TGRKSALLTAQFFFGLGCLLTCFAR-----NVTEFSIARAICGIGAGGLNAISSIAVSDICTAR--ERGVYQGYANIVFGFGQ--LLGAPLGGVFIE--T--I---GWRA-LF---GIQVPVIMLCSVLAIKNI--NIKLFHVP----------PM--------------------------------------------------------------------------------------KERYT--------LK--------NL-----------SRI----DIFGSLSLVATISGVLFLCSSQLN-----------------------KLYLALFTIGS---F-IVFIL--VE-R-------------------Y-----YAT-E----------K-ILPFELL--TRSFCLSSAVTVISSFVV-FGEIFRSPIYLQLLQNISVTKTGLFLIFPSISVAV-GSLVTGWVLR-N-----TKINLAHC-AYQIIFGGMIMQLLGLGLG-----YLLLSHLNPDYTIYD--MLESITF-------RS--N------SIWWKLIYVFASVLVSFGYACLLV-ATLVSIVFTVE-KS------QQGTMTGVFYLWRSIGNVLGASLTLVS-Y--ENSL-SSM----LWN-----YMFKTK-RD----DEYHFTKKQYYS-LINDSS------YLR--GPNFPTDIFVRILDV-YKKAFLISYIPNIALAAVGIVL--SLYLVK---HTYKRS-----SSS-------------------------------------------------------------------------------------------------------------------------------------------------- Saccharomyces_kudriavzevii_IFO_1802_saku_c1803.5 --------------------------------------------------------------------------------------------------------------------------------------------------------MQTLDETSNLL----------------------------------------------------------------------------------------------------PAPEEAEAPPLEQKYHEYNLALPKFPILFSLWLGSFLSSLDSTIVANIMNRVAEDFS------ESSR--KQWIATSFLLTNTAFQPLYGKLSDI-TGRKSALLIAQFFFGLGCLLTCFAR-----NVTEFSIARAICGIGAGGLNAISSIAGSDICTAR--ERGVYQGYANIVFGFGQ--LLGAPLGGVFIE--T--I---GWRA-LF---GVQVPMIMLCTILAIKNI--NIKLFHVP----------PM--------------------------------------------------------------------------------------KERYT--------LK--------NL-----------SRI----DLFGSLSLVATISGVLFLCS-----------------SHLN------KLYLSLFTIGS---F-IVFVL--VE-R-------------------Y-----YAT-E----------R-ILPFELL--TPSFCLSSAVTVISSFVV-FGEIFRSPIYLQLLQNISVTKTGLFLIFPSISVAV-GSLVTGWVLR-N-----TKINLAHC-AYQIIFGGMVTQLLGLGLG-----YLLLAHLNPDYTVYD--MLESITF-------KS--N------SIWWKLIYVFASVLVSFGYACLLV-ATLVSIVFTVE-KS------QQGTMTGVFYLWRSIGNVLGASLTLVS-Y--ENSL-SSM----LWN-----YMFKSK-RE----DEYHFSKKQYYS-LIDDSS------YLR--GNNFPKYVFVRILDV-YKKAFLISYIPNIALAVIGMVL--SLYLVK---HTLKRS-----SSC-------------------------------------------------------------------------------------------------------------------------------------------------- 'Saccharomyces paradoxus NRRL Y-17217 sapa c170 16969' --------------------------------------------------------------------------------------------------------------------------------------------------------MQTLDETSNLL----------------------------------------------------------------------------------------------------PPPEEAEAPPLEQKFHEYNLSLPKFPILFSLWLGSFLSSLDSTIVANIMNRVAEEFS------ESSR--KQWIATSFLLTNTAFQPLYGKLSDI-TGRKSALLTAQFFFGLGCLLTCFAR-----NVTEFSIARAICGIGAGGLNAISSIAVSDICTAR--ERGVYQGYANIVFGFGQ--LLGAPLGGVFIE--T--I---GWRA-LF---GVQVPVIMLCAVLAIKNI--NIKLFHVP----------PL--------------------------------------------------------------------------------------KERYT--------LK--------NL-----------SRI----DIFGSLSLVATISGVLFLCSSQLN-----------------------KLYLTLFTIGS---F-VVFIL--IE-R-------------------Y-----YAT-E----------K-ILPFELL--TRSFCLSSAVTVISSFVV-FGEIFRSPIYLQLLQNISVTRTGLFLIFPSISVAV-GSLVTGWVLR-N-----TKINLAHC-AYQIIFGGMITQLLGLGLG-----YLLLLHLNPDYTVYD--MLESITF-------RS--N------SIWWKLVYVFASVLVSFGYACLLV-ATLVSIVFTVE-KS------QQGTMTGVFYLWRSIGNVLGASLTLVS-Y--ENSL-SSM----LWN-----YMFKTK-RN----DEYHFTKKQYYS-LINDSS------YLR--GPNFPTDIFVRILDV-YKKAFLISYIPNIALAVVGIVL--SLYLVK---HTYKRS-----SSS-------------------------------------------------------------------------------------------------------------------------------------------------- Zygosaccharomyces_rouxii_CBS_732_zyro0g03234g -----------------------------------------------------------------------------------------------------------------------------------------------------------MDDDTAPL----------------------------------------------------------------------------------------------------IPPESRDEESLEAEYHRYNLSLPKLPILTSLWLGSFIGSLDGTIVANIMNRVAEEFE------ESDK--KQWIATSFLLTNTAFQPLYGKLSDI-TGRRFALLTAHFFFGLGCLLTCFAQ-----SVEQFALARAICGIGGGGINACSSIAVSDICTAK--ERGSYQGYANIVFGTGQ--MLGGPIGGLLID--T--I---GWRA-IF---AVQVPIIMFCSFLTYKNI--TIKLSHIP----------PV--------------------------------------------------------------------------------------SERFT--------WM--------NL-----------SRI----DIMGSSSLVVVICGILFICST----------------NWNK------VILSTFTIVGFLF-----FIV--TE-T-------------------Y-----FAK-E----------C-ILPLKLL-KGASGLCSLVTVLSSFITF--GEIFRAPIYYQVVQDMSVTKTGLFVLFPAVSVAV-GSVVTGTALR-H-----TKLDLGHY-CYLIILRSIFTQLIGLLLA-----YVVINGTEPTIGASSSTFAVHWFQF------SS--D------SIWWKILLVSAGCMVSYGYSGLLV-ATLVSIVCSVE-KS------EQATLTGIFYLWRSIGSVLGTSLTLVI-Y--ENSL-TKS----LWG-----------------AMFGSRNDDSYHYTKKEYYNLIGDSSYLR---SHFPVQSIEYLLKA-YRGSFLISYLPSIGLAILGIVTSWVLITVN-------RF-----SRQ-----------------------------------------------KTF------------------------------------------------------------------------------------------------ Candida_guilliermondii_ATCC_6260_cagu_00124 ------------------------------------------------------------------------------------------------------------------------------MKTASEESNSRANTP--------NEKLEVHEPHANHG----------------------------------------------------------------------------------------------------SKLDHELAEKLGASHLNILPTRQLISVLAVLSLGLLMMMTDQSAVTVALPLIGKDLH------AQNT--INWAGTASLLANCVSQVLLGRFSDI-FGRKSVLVSSLVILSIAELCCGFAQ-----TGPQFYIFRAFCGIGGGGVQSMTMVILSDVVTLK--QRGRFQGILGAQIGIGN--AVGPFLMAAFAE--H-----HSWRD-FY---YFLAPTNLLVITAICFVV-------KSK--------------------------------------------------------------------------------------------------KSSTV-----LTRSQ--------KF-----------KKI----DYLGLVFSTASLTLLLIPVSGGG-------STY----AWNS------SLVIVLFIIGGLC-M-ISFILIEWK---------------------------VPP-L----------P-MIPLRLF-GSASLSLLLFFNFLYGMAY-YAFQYYLPYYFQIIRQDSSLRTAVFLLPLVLTQSV-SSTVAGNLIS-I---------MGHY-KIVLCCGFGI-WTLGYGLL-----CIW----------------------------TK--S------TPA--GPLVGILLVIGIGAGCIFQ-PSMVAIQAHAR-KA------DRAVVISARNVLRSFGGAVGIAVGSLI-V--SNSL-LKEVNEELNH---------------------PRIPVEYLH-YLKDHI------YSKISITGLSDSEVSIVKDM-YMSAIKNFFYAIIPIIGVCFVG--SLFIKD---R---GL-----QCI-----------------------------------------------DEIVTTDKDENH--------------------------------------------------------------------------------------- 'Saccharomyces castelli NRRL Y-12630 saca 616.4' --------------------------------------------------------------------------------------------------------------------MVAASSSTSTTDRTLKIQDTGNTDHYLPSNSTASSLHSQRTKEQCSN----------------------------------------------------------------------------------------------------LQPAQAQDQLESMNPPPGPSRLRECMFIVIIASSQFISLAAASQAILQMDAITAWFQLP----ADRSLEAGWANAAFAITCGTFIIPAGKLCDL-IGSKTVFIFGYAWYTLWSLLVGISRYAPKGQATFFFFGRGCQGIGAAALFPSSLALLGKYYPPS-CKKNIVFSLYGFCVPLGV--VVGGVFSAIFTQ--L--A---HWSW-NY---WSMAIVSAFFTLISCFYI-------PPD---------------------------------------------------EIIKSEEQ---------------------------------------KKKRA--------WF--------HL-----------PKF----DYLGTFLYVASLLLFAVCWNQA--------TGF----KFKS------VQVYVTLIVSLVC-F-VAMVI--VE-F-------------------------YVD-D----------P-IIPARKI--HPQTIKALLVVFFSYLSF-TIWLFYLWKYFTVVRNDTVLLGAAKFVPLSIAGFI-AALFSILLIS-----------TAVPVQIRLLAGACS-FLLAHILF-----ITL----------------------------SR--T------ESYW-ARPFLTIIIISIGLDISFP-SATLLLSNGVP-QE------LRGISAALVGTALNYGTGIGPPIAQTI-I-----------------------------------------------------------------GYQCDKCMASGDMDQ-FVKAIHIAAAVGIGASGIAVVV--GLYGTV--------------TEY-----------------------------------------------SWETHSYSKRCVEPYDDE--------------------------------------------------------------------------------- Candida_glabrata_CBS138_cagl0j01375g -------------------------------------------------------------------------------------------------------------------------------------------------------MENLDETTGLLE----------------------------------------------------------------------------------------------------QTPDTTEQDALEQEYHEHNLSLPKLPIVLSLWLGSFLSSLDGTIVANIMNRVAEEFQ------ESDK--KQWIATSYLLTNTAFQPLYGKLSDL-TGRKFAVLTAHFFFGLGCLLTCFAN-----SVTQFAIARAICGVGGGGINAMSSITVSDICTQR--ERGIYQGYANIVFGLGQ--ILGAPIGGLFID--T--L---GWRI-LF---GLQVPTILLCSSLVHKNV-------NIK----------------------------------------------------LSHLLPV---------------------------------------EERFK--------WS--------NL-----------SRI----DILGSSTLVFTISGVLFLCST----------------ELNK------ALLSIFTVIS----F-IAFIL--IE-L-------------------Y-----YSK-E----------R-IMPFELL--KGSFGLASAATVISSFII-FGDIFRSPIYLQLIQGVSVTKTGFFMLFPSISVAV-GSLATGWILR-H-----TKMKLSHCAYWIVTIGMSI-QLLGLVVA-----YYLIQNLEPSLSGSAIFGAFVQIGQ------NISSQ------SYTWVVIYALALILVSFGYACLLV-ATLVNIVFTIP-KS------QQGTVTGIFYLWRSIGNVLGASLTLVF-Y--EKGV-SSF----LWN-----YMFNKQHDD------YNFSKKEYRK-LLSDTS------YLR--SGHFPDGILFELLKV-YRNSFLLSYLPNFILAIAGVAICGGLLVVS---Y----------AQD-------------------------------------------------------------------------------------------------------------------------------------------------- Candida_lusitaniae_ATCC_42720_calu_02219 ----------------------------------------------------------------------------------------------------------------------------------------------------------MTGPTEDTQ----------------------------------------------------------------------------------------------------KGFFESDAGDGTRREEMYLEGKKLVLCFVAIFFCFFLFALDQTIIATLLTTVGNKFN------AFDK--IGWISAGFLISMAVLVAVWGKLSII-FGRKVTMMAAIILFEAGSLMCALAN-----SMNVLIGGRVLAGIGGGGIQSITFIIGTEILPIQ--KRPIAMAILSTVFAVAS--VLGPLIGGAFTS--H--V---SWRW-CF---YINLPVGGAAFSLFVLVY-------NPP-----------K--------------------------------------------------------------------------------------AKGSI--------RQ--------KL-----------KLI----DYPGVILLSAGLVVFLLALTFGAG------GQY----AWNS------AAVIACFVVGGVV-S-IIFFV--WN-V-------------------R-----FSK-H----------P-MLPWEVL-RVFQVEASAFALFGAYASF-ISAVLYLSVYFQVIHDADAWESGVHLLPLIIAVVV-VSFASAIISK-----------VTRYVKPFAVFGAFL-GMVGAGLL-----CLL----------------------------EV--D------SSS--SRKIGLLIPMGLGIGFLMQ-ACMLSGQISAP-KTPG----GTILATVLVNFMRSFGGALSSNLADAV-Y--SASY-LNKVHENLKK---------QPEEV------IKELSTIDVRAIVSSTA------AIA----KLSAPAQKFLKHQ-VMSAIRNTFYMNLGFSAIAVIA--VCFITN---K---RL-----PDA-----------------------------------------------SVQERDEKITETKPAENDSAEPTRSGTAK---------------------------------------------------------------------- 'Saccharomyces paradoxus NRRL Y-17217 sapa c214 2150' -----------------------------------------------------------------------------------------------------------------------------------MLKSVRHKSLPKNGDGNYGSIEGDEIPFVEYN----------------------------------------------------------------------------------------------------EGAEDLDEDLDKDEDMALSRIPNLWIIEATLFSNVFLSGFDGTVTASTYQTIGNEFN------QMSI--SNWITTAYLITSTSFQPLYGSFSDA-LGRRNCLFFANGAFTIGCLACSFSR-----NIYMLSFMRALTGIGGGGLITLSTIVNSDVIPSS--KRGIFQAFQNLLLGFGA--ICGASFGGTIAS--S--I---GWRW-CF---LIQVPISVVSSILMNFYV-------PNQ------------------------------------------------------KEYNHQNSS-----------------------------------IFQNP--------KK--------IL-----------TDI----DVMGSILIITGLTLQLLYLSLGCST-----SKL----SWTS------PSVLLLLVGSVII-L-LLFIL--HE-R-------------------K-----TSA-R----------A-IIPMELV-SSSYSFVVLLISILVGFAS-YAYLFTLPLFFQIVLGDSTAKAGLRLTIPSLFTPV-GSLITGFSMS-K---------YNCL-RLLLYIGISL-MFLGNFLF-----MFI----------------------------EK--T------SPN--WLIGLFLVPANLGQGITFP-TTLFTFIFMFP-KS------DQATATSTLYLFRSIGSVWGVAISAGV-I--QLSF-ASF----LRS-----NLKGLMDES--------KIKKLIVK-LSANSS------YIG----SLHGEVKDTVINS-FDAATKRAHLLSTLLSLLALTL---GILKD-------NL-----AKP-----------------------------------------------KTRK----------------------------------------------------------------------------------------------- Pichia_stipitis_CBS_6054_pist_igi19055263 -----------------------------------------------------------------------------------------------------------------------------------------------MDPSNKKEKDQVHIVEKVKR----------------------------------------------------------------------------------------------------PHRDSDLSDQLGDAHFNILPQRRIITILLILALANLVSFADQTGITVGLSAIASDLN------SEKT--INWAGTASLLANCVCQILFGRLSDI-FGRKNVLMWCLAILIIGQVACSTAR-----NGPEFYVFRALAGIGNGGVSSLGMVILSDIVSLK--DRGKYQGILGASVGLGN--IVGPFVMSAFVK--H--Y---SWRG-FY---YLFAPLGCLVNVAIYFTI-------DGN----------TK--------------------------------------------------------------------------------------LDGVL------SKKE--------KF-----------KKI----DYLGIIIASIALTCLLVAISGSG-------TSF----PWDS------KLTITLFCVGGIA-F-IVFFLVEWK---------------------------IPE-L----------P-MIPLRLF-KSPSMCLLFASTFLFGATY-FSLLYYLPYYFQIVRSKSEIQTSVFIVPLVAAQAL-MSIVGGQIIT-L---------TGHY-FFVVCGGYAL-WLTGCGLL-----IIW----------------------------NE--H------TSD--GVLVVVMLIIGTGVGFSFQ-PSMVAIQANCK-KA------ERAVAISTRNVLRSFGGAIGIASGSTM-I--SNTL-LNHLAQIQGQ---------------------SDLTEATID-YLKDHI------YSKINLAGVSASEITTISQL-YISALRYYYYLIVTFMGICLVC--SIFVKD---R---GL-----QCT-----------------------------------------------DEHPVRTRKDLESSASSYTVNS----------------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0c02178g ---------------------------------------------------------------------------------------------------------------------------------------------------MSDETAALLVPVISPT----------------------------------------------------------------------------------------------------TETALVDTGEESTTSHSELPPTKVRITVLALLMGSFLSALDTTIVATLLPTIASDLD------ASSQ--MSWIATAYLLSCSAFQPLYGKLSDI-FGRKILLILSNLTFALGCAICGSPWTN---NVWVLSTGRFVAGIGGGGQATLSTITTSDIIPLR--KRGVYQGLVNICFSLGC--ASGSVLGAVLQQ--G--I---GWRW-AF---LVQVPMALVCALMIAVVL-------DLP----------AD----------------------------------SPGRGLLWLELKRGKRL-----------------------------------KWCTV--------TE--------MV------------------DFVGSFTLIASMILLMTAISLLS-------DPT----QLST------SLWLLLGVLLTAS-S-LQFAY--TE-C-------------------T-----TR--N----------P-MVPLRLLWENRTVCASSFTNWFMTMTT-FTVMYYVPVFWHTVYKFTPWDIGVRSMSNFVGIAS-GSMLAGMYMK-R---------TGKY-WSFSVATNSL-FAVGVLSL--FAFSFK----------------------------GSPQG-----------VVEYLLMFLPGFGYATMLT-VTLLALIASVS-VE------HQAQVTSIQYAFRATGSTLGVALASLI-Y--QSCL-QSRLYNNVLT-----------DGPLLAQYGSRRLMDWCQSILQDNSF-----------DISFDHRLAELVRQG-FQFSNQCALGFAFVVCVLGVLS--SCFMRE---H---VL-----HTS-----------------------------------------------VSRK----------------------------------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0e04246g ---------------------------------------------------------------------------------------------------------------------------------------------------MPQETDLLLAPCLSPI----------------------------------------------------------------------------------------------------PEIPTFDSSYDAAANHSVLTETKTRIIVIALFLGSFLSALDTTIVSTLLPTIASDLD------ASSQ--MSWIATSYLLSCSAFQPLYGKLSDI-FGRKILLVWSNLVFAIGCALCGSPWTT---NIWILSAGRFIAGIGGGGLTTLSTITTSDIIPLR--KRGVYQGLGNICFSLGC--ASGSVLGAVLQQ--G--I---GWRW-AF---LIQVPIALISGLLIVFVL-------ELP---------SDS-----------------------------------PGRGLIWLEHAR---------------------------------------GNTFQ--------WS--------KV-----------TKMI---DFVGSITLVMSMLLLMITISFLSD------PSQ----LSEN------SWVVLVLLVAGFC---AKFVH--TE-C-------------------T-----IHN------------P-MVPLRLLWENRTVFASSFTNWFMTMST-FAVMYYIPVFWQTVFKFTPYDIGFRSISNFVGIAT-GSMLAGVYMK-C---------TGKY-WNFSLVTNIL-YFTGILSL--FACTFR---------------------------------------NTPQGVLEYLLMFLPGFGYATMLT-VTLLALIASVD-FE------HQAQVTSIQYAFRATGSTLGVSLAGLI-Y--QASLQYKLYRDILGD------------QTLLGKYGQDQLRKWCKEILQDNSF-----------DTSFDQRLAKEVHRG-FQFSSECALGFALAACTLGVVL--SCFMRE-------HVLGKTVPSK-------------------------------------------------------------------------------------------------------------------------------------------------- Yarrowia_lipolytica_CLIB122_yali0e18095g ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLLTLIALYTGVFLSALDATIVTSIYATIASDLN------ELSR--ISWIATGYLVSCAAFQPLYGRLSDI-FGRKAMLLVSSACFGVGCTLCGLSY-----SLMPLIVGRVIAGIGGGGLLTVSTIAVSDLIPLR--QRGIYQGVGNIAYGSGA--AIGGALGGVLSQ--W--I---GWRG-VF---LIQVPFIVCSGTLVVFGM-------TNSNTKNQKLDDPESADENADENTPVSPLTTSPADSDVANPLSGANSSVLYGSVESENLPHAKSTDSDP--------------------------------TGETT--------WQ--------KV-----------KNI----DFAGSALLVTSLSLLLFAISSA--------TKS----AWTE------PIIYTPLIISVIA-G-VVFWN--YE-L-------------------K-----CAN------------P-VIPVSLL-YRQTIFASSLTNLFMTMGI-FAMLYNVPLWYKSVLGDSDAKAGARLVGNFIGVSF-GSMSSGIYMR-K---------TGKY-YNLGIAAGVL-TTMGVFAL-----IPL----------------------------SA--E------TPA--WLQYTMLFVPGAGYAAMLT-VSLLALISAVS-NQ------EQATATSIQYAFRGVGSTLGVSLSSTI-F--QAVI-SKWLPVKMYA--------VVDKPT----PKEVRLIELTIAAVKESVT------AIR----EAPAKFQPAIIAS-YDLAIKDVFFYATAMCAISTIC--LYFVKE---H---EL------RQ-------------------------------------------------------------------------------------------------------------------------------------------------- Pichia_stipitis_CBS_6054_pist_igi19986138 --------------------------------------------------------------------------------------------------------------------------------------------MSRDSSTEAPQALVEDPEKQSQK----------------------------------------------------------------------------------------------------KVFIESDAGDGTKREDQYLHGIHLVICFVAVFLSMFLVALDQTIVTTILTTVGNKFN------DFDK--VGWLASGFLLAMAVCIQPFGKFSII-FGRKYTMVTAIVLFEAGSLMCALAK-----SMNVLIGGRVLAGVGAAGIQGMVFVIISEVVPIE--KRPIGMAIISSVFAVAS--VLGPLIGGAFTS--H--V---SWRW-AF---YINLPIGGIALAFLLWAF-------NPP-----------R--------------------------------------------------------------------------------------PTSSI--------VE--------EL-----------KTF----DYFGTFLLISGCVIFLLALTFGG-------SDF----SWDS------AAVILCFVLGGLL-I-IAFII--WNGW-------------------------FSK-N----------Q-IIAVEVL-KIPQIVASTFALSGVFAAF-ILSMVFLPIYFQVIHGASAMGAGLHLLPMIVAVVL-CSIISGVGIQ-K---------SKYV-KPFSVAAGIL-APVGFGLL-----AIL----------------------------GV--D------SSF--SAQVGLLIIGGIAVGAQMQ-PAIVSAQICAP-KTPG----STIMVTVFLNFSRSIASALAADLGDAI-Y--ASSF-KNY----FKK-----AFKATTNTT----ILSDLQDVDISE-LVSNTS------VLA----QLNPVTQHFVKTQ-IVKAIRNVFYMGIGLSAITFIA--CFFVTN---K---NL-------------------------------------------------------LKNVQKDHQRSTVQFTPQFA------------------------------------------------------------------------------- Eremothecium_gossypii_ATCC10895_ergo0b04004g ----------------------------------------------------------------------------------------------------------------------------------------MDESE--------SQLRGTLLPHDSLE----------------------------------------------------------------------------------------------------YGTNSDKTLTETQRCQEHNRSLPKAPILTSLWLGSFLASIDASIVANIMNKIAEEFH------ESDK--KQWMATSFLLTNAAFQPLYGRCSDI-VGRKCALLIAQSFFLLGTLLTCFAR-----NVTEFAIARAICGMGGGGIGAMSSITVSDICTTK--ERGMYQGYANVIFGAGQ--VLGAPVGGLIME--T--F---NWRI-IF---AAQVVAIMICMILAYRNI-------NLK----------------------------------------------------LLHIPPF---------------------------------------HQRFT--------RK--------NL-----------SRI----DLFGSSMLSCSLVSFLMLFSSGV-------SRS----LW--------------FLLTLVS-L-TLFCI--NE---------------------R-----YIATE----------R-LLPNGIL-RGHFGLSALLIVVSSFMMF--AELYRMPVYLQLIQDISVSRSGIFLLFASVSSSG-ASLFTGWLLRTT------KQDLGKLVYKIALASSFI-QLVGMMLA-----LFTTSVTEPSQAVHAGWAVFSPRSAGQMHYFKS--D------SIAWRVLLTVALMCSSFAYASLLV-SILVSIVDTTE-KS------QQATMIGVFYLWRSIGNTLGASVPLSV-Y--EFEV-ARK----LWD-----------------YMEAQGLRDTYLD-LLHDSS------ILR---QRFRNHTLAALLQI-YRSCFQVSYLPSICVCILGILA--ATRLTQ-------RA-----AHK-------------------------------------------------------------------------------------------------------------------------------------------------- Debaryomyces_hansenii_CBS767_deha2e02794g -----------------------------------------------------------------------------------------------------------------------------------------------MSQQNKIHSLEKDSDINVMQ----------------------------------------------------------------------------------------------------KSINSDLSEKLGDSHMNILPTKKIVICLSVLAMALMISFIDQTGVTVATSVIGKDLD------SETT--INWAGTASLLANCICQVLFGRLSDI-FGRKNVLMSGLLILAIADIGCGVSQ-----TGVQFYVCRALAGIGNGCSSSLPQIILSDIVTLR--DRGRYQGILGMSIGLGN--SIGPFLMAGFIH--G--A---TWR--CF--YYMLCPLNLLVIVVIYVFI-------KNP----------VK--------------------------------------------------------------------------------------KLEII-----LTRKE--------KF-----------MKI----DYIGIFFATACLTLLLIPISGGG-------STY----PWNS------PIIIAMFIVGGGL-F-FVFLLVEWK---------------------------FAK-L----------P-MIPLRIF-KLPMVSLIFLSTFFFGMAY-FSFLYYQPYYFEIVKDKDIVHTSLFVLPLVLCQAV-MSAVSGQIIT-Y---------TGHY-IYVIITGYAL-WLLGNCLL-----LLW--------------------------------N------ENVNDGVNVVSLLIIGCGVGFTFQ-PSMVAVQAQAK-KA------DRAVVISTRNVIRSFGGAVGIAVGSTT-V--SNSF-LNNIKQLEKD-------------------NTTKIPSSYLR-YLETNI------YSRFDTSSLTTKQTSAVRLM-YVNALKNYFYLLIPFIAICLIT--SFFIKD---RGLQCI-----DEI-----------------------------------------------EPPTRKNSDTESSVSRNRA-------------------------------------------------------------------------------- Kluyveromyces_thermotolerans_CBS6340_klth0b00132g ------------------------------------------------------------------------------------------------------------------------------------------------MTEIETGQNSEYNRKISDE----------------------------------------------------------------------------------------------------TKDLSVKQSACIAPDASKRNRVKLFLSLLSLGLSMFVTALDVLIVGTIIDTVCTSFG------DYTK--SGWIVTGYSLPNALFSLLWGRLSAV-LGPRISVISCIILFETGSLISALAK-----SMNMLISGRVIAGVGGSGLQTLSLVIGCQLVNEK--SRPLVLSLLNCTFAVAS--IVGPFLGGAFTT--H--V---TWRW-CF---YINLPIGGLAIAIFIFFY-------NPE----------GA-----------------------------------DLLEKGSQTFKKLLSYRRANLS-----------------------------LKQLL--------DQ--------LL-----------FGF----DIVSFVLFTAGWLLFLLALTFGG-------QTH----PWKS------GIVISFIIVGVLL-I-ALSLI--YD-F-------------------R----LFDHIKTMDT---F-RP-LLSWHLM-SQRAILNANFTGFFSTIAY-NVQMIYSVQFFQLVYGFSAWKAGLHLIPILVSTVV-FSIASGVIIK-K---------TGHI-KPLLVFGSAM-GVLGSGLM-----ILL----------------------------NN--T------STK--HTQIGVLILPGVALGFVLP-AALITCHVQLD-RTSPSYGADMLETTSVNALLKSLGTTVGSILSTMV-F--STSL-HNK----MKN------------------------SNILFE-VSGELD------SIASYRLDHFDGPRSEMGCM-LNDSIRNTFWMALGSSVVAFLC--SLLVSR-------RK-----VSM-------------------------------------------------------------------------------------------------------------------------------------------------- Kluyveromyces_thermotolerans_CBS6340_klth0b10142g ------------------------------------------------------------------------------------------------------------------------------------------------MSDIETGIHSDRDRKISGE----------------------------------------------------------------------------------------------------SDDLSLKHKRCITLDRPKINKVKLFLSLFSLGLSMFVTALDVLIVGTIIDTVCKTFG------DYTK--SGWIVTGYSLPNALFSLLWARLSAV-LGPRISVVSCIILFEAGSLISALAN-----SMNMLIAGRVVAGIGGSGLQTLSLVIGCQLVDEK--SRPLVLSLLNCTFAVAS--IVGPFLGGAFTT--H--V---TWRW-CF---YINLPIGGLAIAIFVFFY-------NPE-------------------------------------------------GVNLLEKFGNTFKKVSSFHPVKKS-------------------------PKKVL--------QQ--------LL-----------FGF----DILSFISFTAGWLLFLLALTFGG-------QTH----AWNS------GIVISFIIIGVLL-I-AISLV--YD-F-------------------K----VFEQIK----TQDSFRP-LLSWEIM-SNRSILLSNFTGFFSTVAY-NVQMIYSVQFFQLVYGFSAWKAGLHLIPILVSTVV-FSIASGILTK-K---------TGHI-KPLLVFGSAM-GVLGGGLM-----TLL----------------------------DN--K------STK--HTQIGVLILPGVALGFVLP-SALIACHVQLD-KGNPSYGADLLETTSVNALLKSLGTTLGSILSTMV-F--STSM-NNK----MKH---------GGLSL----EEYDRLDGIASY-RMDHFD-------------GPRSEMGYILSDS-----IKNAFWMALGSSAIAFLC--SIFVSK---R---KI--------------AM------------------------------------------------------------------------------------------------------------------------------------------ Kluyveromyces_thermotolerans_CBS6340_klth0h05456g --------------------------------------------------------------------------------------------------------------------------------------------MGEEEGRPGSIELDEIHSSKGES----------------------------------------------------------------------------------------------------TVPSFPDTGEEEDLEKDFRDPNTFPYILLSLWLNTSICAVDGTIISTTMNEIASIFQ------EASK--VTWVATAYMLTTCAVQPLYGKTSDL-LGRKKCLLFAEVVFIVGLVMCGAAR-----TIEELIVARAICGVGGSGLGAMCNIILSDLAPLS--QRSIYWGWGSVIWGFSQ--SVGGPLGGLLLN--W--F---GVRG-LF---VVQIPFCLFSLSLTVKYI-------HDL----------SN--------------------------------------------------------------------------------------QTQGT--------WR--------DI------------------DFAGSFCLITGISAFIFLCSSSG-------DVT--DDSAVS------LFKVGCFLITVLS-V-SGFIY--VE-K-------------------N-----VAA-K----------S-ILPAEVL---KGSLGVISFIYGLASMLSYVGLFVVPLYLQLVWGVSVAGSGGYIMYAVISTSI-GSFGSGWLLR-K---------YGAPDKDATLLNSGM-MLIGSTLINTLGFFVMFKNILEIKPAFE----------------GVKSP------SPDQKFWFLLGFAIMGLSAGFQSV-SVMLYTVAKVG-RK------GQASSTSVTFLFRSLGNVLSVSISLSV-F--VASL-KGK----LKS------------------YFQGQQSDLYRK-LLKENA------FLR--SGEVPSDQLKDLLQV-FKSAIVKAFWPSVVCCFLSVTFAGVLFVMI---R------------------------------------------------------------RSRRFAGLSA----------------------------------------------------------------------------------------- 'Saccharomyces castelli NRRL Y-12630 saca 660.3' ----------------------------------------------------------------------------------------------------------------------------------------------------MDPLDETSSLLPIRS----------------------------------------------------------------------------------------------------SIEDGEEDNGLEEQYHEYNLSLPKFPILLSLWLGSFLSSLDSTIVANIMNKVAEEFE------ESDK--KQWIATSFLLTNTAFQPLYGKLSDI-TGRKFAVLTSHFFFGLGCFLTCFAQ-----NITQFSIARAICGIGAGGVNAMSSITVSDICSTR--ERGIYQGYANIVFGLGQ--LLGAPLGGLFID--S--V---GWRV-IF---GVQVPMLLLCSTLATRNI--NVKLAHIP----------PR--------------------------------------------------------------------------------------KERFT--------WK--------NL-----------SRI----DIFGSLALVGTISSLLFLTS----------TTL--------------NKIVLTLSMIASF---ILFIW--IE-L-------------------Y-----YAK-E----------R-ILPFDLL-KGSFGLCSLVTVASSFVVF--GDIFRSPIYLQLVQDISVTKTGLFLVFPSIAVAG-GSLVTGWILR-H-----TKKNLSHCAYGIILGGVCI-QLCGLVIA-----YYLIKNLKPAMVHIDDSAMAFFTF-------TP--N------SIMWKIIYALALILVSYGYASLLV-ATLVSIVFTIE-KS------QQGTMTGIFYLWRSIGNVLGASLTLVI-Y--ENSL-AKK----LWN-----YMFETNNKK----DSYIFSKEEYYT-LVRDSS------YLR--AANFPALTLRSLLNV-YRDSFLISYWPNIALAFLGLIV--SWVLVR-------KY-----PRT-----------------------------------------------TKI------------------------------------------------------------------------------------------------ Saccharomyces_mikatae_IFO_1815_sami_a_c699_5023 -------------------------------------------------------------------------------------------------------------------------------MLKSTKHSSLQKNANGSYGSIERNEDPFIENNEEIE----------------------------------------------------------------------------------------------------NLNEDLDEDLDKDQDIALSRIPNLWIIEATLFSNVFLSGFDGTVTASTYQTIGNEFN------QMSI--SNWITTAYLITSTSFQPLYGSFSDA-LGRRNCLFFANATFTIGCLACGFSS-----NIYMLSFMRALTGIGGGGLITLSTIVNSDVIPTS--KRGIFQAFQNLLLGFGA--ICGASFGGTIAS--T--I---GWRW-CF---LIQVPISMISSILMNYYV-------PNQ------------------------------------------------------KEYNDQNSK-----------------------------------IFNDP--------KK--------IL-----------TGI----DVMGSILIITGLTLQLLYLSLGC-------STSNL--SWTS------PSVLLLLFGSVII-L-LLFIL--HE-R-------------------K-----TTA-R----------A-IIPMELV-SSSYSFVVLSISILVGFAS-YAYLFTLPLFFQIVLGDSTAKAGLRLTIPSLFTPV-GSLITGFSMS-K---------YNCL-RSLLYLGISL-MFLGNFLF-----LFI----------------------------EE--T------SPN--WLISLFLIPANLGQGITFP-TTLFTFIFMFP-KS------DQATATSTLYLFRSIGSVWGVAISAGV-I--QLSF-ANF----LCT-----NLKGLLDEN--------TIKKLVIK-LSDNSS------YIG----SLHGEVKSAVIKS-FDAATKRAHLMSTLLSLLALIL---CVLKD-------NL-----ARP-----------------------------------------------RTRK----------------------------------------------------------------------------------------------- Pichia_stipitis_CBS_6054_pist_igi16259683 -------------------------------------------------------------------------------------------------------------------------------------------------MEDIKVQTSRVIDVNDSQ----------------------------------------------------------------------------------------------------VIEKQALDDRLGDAHLNILPTKKIIVCLAALSLGLFASFADQTSITIALPAIAKDLR------AETT--INWAGTAALLANCVCQVLFGRLADI-FGRKNILLFSLGTQAVADIGCAVSR-----TGVEFYIFRAIAGIGCGGTQSLTMVMLSDICTLK--QRGKYQGILGAQVGLAN--ALGPFIMAAFVE--H--T---TWRD-FY---YMMIPLVISVMVTIYFLI-------DGK----------------------------------------------------KNASQLN---------------------------------------NVLSR--------KE--------KF-----------KKI----DYLGMFFSTASLTLLLIPISGGG-------SSY----PWNS------PLIIGMFVSGGLS-F-FVFIYIEWK---------------------------LAE-L----------P-MIPLRIF-ASPSLSLILGSNFLYGMAY-YGFTYYLPYYLQIVRGLDSIHASIILLPLVLTQSI-ASIIGGTLIS-Y---------FGHY-KNIILMGYGL-WTVSCGLL-----YIF----------------------------NT--Q------TNW--GVIVVILLVMGVGVGWTFQ-PTMVAAQSQAK-KS------DRAIVISARNVLRSFGGSVGISIASMI-V--SNSL-LREIRRESKN--------------------EGSILDGYLD-YLKDHI------YSRVDTSKLNHAQQVVVREM-YMKAIKNYFYICLPLIAVCFIS--TIFVVD---R---GL-----QCI-----------------------------------------------DEEPEQKNKDKESDIDTSSNSSRQ--------------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0a08228g -----------------------------------------------------------------------------------------------------------------------------------------------------MFSVSEPNNQPKPI-----------------------------------------------------------------------------------------------------------------------SLLRLIMCIISLLLVLFLSSLDIIIVVTILNTIADKFN------AYSK--IGWLITGYSLSNALFTLLWGRFAVI-FGSKTTLMVSIIIFEIGSLVIAVSN-----SMDMIIGGRVIAGCGASGIQTLVFAIATSLVDEH--TRGTIVTLLSLSYAVAS--ALGPYIGGALTE--Y--V---TWRW-CF---YINLPIGGLALGVFYLSY-------NPA----------QR-----------------------------KVLKCFPHFFKSVTSLEFKQLLSLKF-------------------------------YRMLL--------KF--------LV-----------FEL----DFFGFTFCSVGFVLLLLGLTFGG-------NLH----PWQS------GTIIAYLVVGSFF-I-VIFFV--YE-FVIFDMFWQSQR--------N-----GNA-R----------P-LISWTTF-SKSGIFTATATMFFGCCAY-NLQSIHVVQLFQLVFGQSPSRAASHLWSLLIPAFV-SIIISGKITS-R---------YGYV-KPITLFAGIS-GVIGAGLL-----TLL----------------------------NG--E------STN--SEQIGYAILSGAAFGCINL-STLLSAQIQID-KSDPKYDEKFIEVTALNTFGKSLGISLGGILGTTV-F--TASV-KNK----LSN---------HNYDA----NIGKSVEALIAY-RSQNFD-------------GPNSEIGRLLTSS-----IRNVFFTSLGFSCMAFIF--GIFTSK---K---RV-----EKS-----------------------------------------------VQKERVKGDLEENHGNP---------------------------------------------------------------------------------- Yarrowia_lipolytica_CLIB122_yali0c22660g ---------------------------------------------------------------------------------------------------------------MVMFKRSKKTVETVETLPTGADTDNARLPDKNGLETHNEKCRPEGTTNDTND----------------------------------------------------------------------------------------------------TNEMMPDREKNGARPPIFSSTWKEIICIFLLALSPVLEALTTGALLVALDKIGQSYKI-----EGGQ--LSWTLSAFSLGTGSSLLIMAGLADS-FGRKKTLIAGYTVFAATSLISGFMK-----NDVAFDVLRAIQGVATGAAIPASVGILGSIYRKPSKRKNRAMAGFAAGAPLGF--VVGLVVGGICGE--F--I---GWQG-IL---FFFAIMYFLAALACVWYV-------PPD---------PPM--------------------------------------------------------------------------------------SKPEV--------IE--------KL-----------KNL----DYGGAALCLAGFTLFVFAMTHADS------TEK----GWKT------PYIIGLFVTGFVL-I-VLFVL--YE-C-------------------Y-----IAS-N----------P-IMPPHIW-KCKGFAVCMACVALGMSTFLGTTQFYITMYFQNIKGTNPILTTAYFVPMVVAGIC-VNVFAAMTLH-----------LIPG-RFLMMLAQAG-FFGAALLM-----ALV----------------------------GV--H------TSYW-AIPFPAEILSVIGADLLYN-VSTLLTINSVS-ED------LQSRAAGIFNTIAMLSAAVALAAASSI-A--SAKV--------------------------------------------------------------SADETHKVSKET-LLDSYHAAFWFSVGTSAAGLVL--SFFLDL-------GT-----SGG-----------------------------------------------DEGKDVDQDTEEVETDSITGVNNN--------------------------------------------------------------------------- 'Kluyveromyces waltii NCYC2644 klwa 305-snap.8' ---------------------------------------------------------------------------------------------------------------------------------MTKNDDLLDSLE--------LEEVRNYKVGENTG----------------------------------------------------------------------------------------------------DEGIYDLEETEEDLERDFRDPKTFPLVLLSLWLNTSICAIDGTIISTTMNEVASIFQ------EASL--VTWVATAYMLTTCSVQPLYGKTSDL-LGRKKCLLFAEVVFIIGLVLCGMAR-----TVKELAIARAICGIGGSGLGAMCNIILSDLAPLS--QRSIYWGLGSLIWGFSQ--SIGGPLGGLLLN--W--F---GVSG-LF---VIQVPFCLFSLFLTVRYI-------HDL----------TD--------------------------------------------------------------------------------------QRQGT--------WR--------DI------------------DFAGSFCLIIGISAFIFSCSAGDG------VDS----NDEG------PFKVVCLIVTIAA-V-AGFVV--VE-K-------------------R-----MAT-K----------S-ILPAHVL---KGSLGVVGLIYGLSSMLSYVGLFIVPLYLQVVWGTSVAGSGGYIIYAVVSTSV-GSFSSGWLLR-RYGSPTRCTTLFNS-GIMLVSSTLI-NVLGFAILFRNILSIS----------------------------PNFENTGGPSGSQK--FWFLLGFVIMGCSQGFQNV-SVMLYTVAKVG-RK------GQAASTSVTFLFRSLGNVLSVSIALSV-Y--VASL-KHD----LTI------------------YFEGQKTDLYFK-LLKENA------FLR--SGSVPEDQLKDLLQL-FKAAITDAFWPSVGCCFLSVIS-ATVLFKL---V----------QRS-----------------------------------------------RYSESLNL------------------------------------------------------------------------------------------- Pichia_pastoris_GS115_pipa_1g01100 -----------------------------------------------------------------------------------------------------------------------------MSETTPLLPEIIEDPS--------TGTPGIVANELMQE------------EQLTKV----------------------------------------------------------------------------------YSSSRSTGSLASSDGEYAVPSKQLYVIISSLFMCSYLSALDTTVVTTLLSTISSDLE------EMDR--SSWIATSYLLSCCAFQPLFGKISDI-FGRKVMILLCIGSFAIGCLISSYSY-----SLWPLVISRYLAGIGAGGMSVLGTVAMSDLISLR--KRGVFQGGANIFYGLGS--ASGGVIGGLIAD-NW------GWRA-VF---SFQVPIALCCATAITICF-------HLP---------------------------------------------------EGSPGNGY---------------------------------------PNSDM--------WK--------KF-----------QSI----DFAGSILLATSLTGLVAAAALGG-------HEL----PYGS------ASFILLVVISLGL-L-AWFAY--IE-L-------------------H------SE-Q----------P-AIPIELL-NTRTVLSACLANWFYSISV-YSYMYYIPIYFTTSMDFSPTDNGLRMIPNFFGIAF-GSVGSGIYMR-K---------TGKY-LKFIAVTCLL-GVLGTIRI-----CFI----------------------------NP--D------ISL--FTQFTLTVVPGFGYSCMLT-VTLLALIASVP-ME------KQASTTSIQYAFRSTGSTIGVSLAAAI-F--RHGL-STT----LGR-----NVSNALPDT----EDPKIISEILQQ-ALKSTD------YIK----EAPKWAIEAIRSS-YDFSCHLVFYFCLITVTMGYVS--VMMMRE---H---KL-----HTS-----------------------------------------------VNRE----------------------------------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0e02992g ----------------------------------------------------------------------------------------------------------------------------------MDKATADERTN--------LLPDTLDPQSLSLN------------L---------------------------------------------------------------------------------------EDEFNRKNSSLEEEYHKHNLDLPKLPIVFSLWMGSFLGALDGTIVANIMNRVAEEFQ------ESDK--KQWIATSFLLTNTAFQPLYGKLSDI-TGRKFALLVAHTFFCLGCLLTCFAR-----NVTEFSIARAICGIGGGGISAMSSITVSDICTAR--ERGAYQGYANVVFSTGQ--LLGAPLGGFALD--R--I---GWRA-IF---GLQVPMLLICMVLGYRNV--NIKLAHVP----------PL--------------------------------------------------------------------------------------EERFT--------WK--------NL-----------SRI----DIGGSITLVCTISGVLFLCS----------TSL--------------NKAILSVFTGLSF---MLFMY--NE-L-------------------Y-----LAR-E----------R-ILPFELL-GGSFGLASILTV-GSSFVI-FGDVFRSPIFLQLVQNISVTKTGGFLLFSSIATAA-ASLITGWILR-N----TKMNLAKCS-YLIVFFSIFL-QLCGLVIA-----VTLLSYLEPNQTSLMANNTR----LKRDYLFKS--D------SLAWKCVYICASAFTGYGYASLLV-STLVSIVFTID-KS------QQATITGLFYLWRSIGNVLGASLTLSL-Y--EATL-SKK----LWSYLSAND-----------------ITEQYNN-LSRDSS------YLR--K-NFSGELLSGLLDV-YNSSFIVSYVPSVGICLCGIVL--AWALIK----------------------------------------------------------------LCRTL---------------------------------------------------------------------------------------------- Kluyveromyces_lactis_CLIB210_klla0f13684g ----------------------------------------------------------------------------------------------------------------------------------------------------MNHSTDETTRLLSNR----------------------------------------------------------------------------------------------------ITSSSADEDDLEEMYHRHNLALPKGPILYSLWMGSFLGSLDSTIVANIMNKVAEEFE------ESDK--KQWIVTSFLLTNTAFQPLYGKLSDL-AGRKTALMVAHSFFLVGCLFTALSR-----NLVEFSIARAVCGMGAGGISALSSISVSDICTPK--ERGVYQGYANVVFGTGS--MLGGPIGGWLMD--S--F---GWKV-IF---AGQVPLIMTCMFLGYRNV--NIKLLHVP----------PR--------------------------------------------------------------------------------------HERYR--------WE--------NI-----------KRI----DLGGSISLIGTISGFLCLCST----------------DLNK------PLLATLTLLSLVL-----FIM--NE-L-------------------Y-----WAP-E----------R-IIPTDLL-SGTFGITSLLTVFSSFIAF--GDVFRNPVYLQLVQNISPTSTGGFLLFSSISSAL-ASLATGWILR-N-----TSLGLATCSYLLITIAVCL-HFISLSLGYTTISHLEPNPTSHVSALDTS---------------GT--NYWFTSNQFRWRVLYVIAMILNSWGYASLLV-ATLVSIVFTIP-KS------QQATITGCFYLWRSIGTVLGASSVLTI-F--ESSA-TTK----LYQ-----------------YLHPINMDKEYES-LIHDTS------FLR---NHFSGKILRDLLEI-YNESFLISYIPTFAVSILALIIAFKLFISC--------------DKE-----------------------------------------------VTETKDDSSDSS--------------------------------------------------------------------------------------- Kluyveromyces_thermotolerans_CBS6340_klth0d16962g -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRKVAVIVCVTSLCVTLFLGALDIVICITLYDTIGQEFN------DYAN--VGWLMAGYNLPNALFMLLWGRIASL-VGLKCSLMASIVIFEAGSLMAGAAN-----SMGMLIGARVISGFGGSGIESLVYGVGTSIVEEK--HRARVITVLGIAYMLAE--GAGPFVGGGLAE--H--V---SWRW-CF---YVNLPIGGVALAALGWGY-------NPA----------GR--------------------------------APGRALARFWVRARAFPYGTLLQAQF----------------------------WRRAA--------AL--------MV-----------FRL----DIPGLALSSGGFALVMLALTFGG-------NQY----AWRS------ATIVCMFVFGAAL-L-ALFML--YD-FVVLPRVGARIA--------G-----YEP-L----------P-LVPWRLA-ANVPVLTSSLCGFFNCFAF-ELQSIYLVQYYQLVVNKGPTLASVHLWQMSLPALV-SVIASAVVNE-R---------FGVV-KPLVLAGVVM-GFVGSGLL-----TLV----------------------------RS--D------TTL--GQSIGFSVLAGASFGCVYQ-LSLISAQLQVE-RDDPDFHARFIEVTSYNTFIKTLGFSFAGIVSTTV-F--TVSL-KNLASSHSAS-----------------VPSFSTVEDLIRY-RSENFD------------------GRNSLLGRLLAKSVRNVFYCALVCSALSFLF--GLFTSK---K---RT-----DIT-----------------------------------------------KGAESTELAELCELAEPAEEKPVSKTPTSTLC------------------------------------------------------------------- Saccharomyces_mikatae_IFO_1815_sami_a_c322_9452 -----------------------------------------------------------------------------------------------------------------MVSANSHDYVSGEKIHVLTDVEHELNAETHTGSNSISFGLPQLSEKYDAL----------------------------------------------------------------------------------------------------RQNRSLIIQQTEIFGAAYNKWYLQVFLLLSAFICGYGYGLDGNIRYIYTGYATSSYS------EHSL--LSTINVINAVVSAASQIIYARLSDV-FGRLYLFISAVILYVVGTIIQSQAY-----DVQRYAAGAIFYNAGYVGVILILLIILSDFSSLK--WRLLYQFAPTWPFIINT-WIAGNITSRANPV--V------NWSW-DVGMWAFIFPLSCIPIVLCMLHM-------QWR----------AK-------------------------------------KTPEWHTLKGQKSYYQEHG------------------------------FIKII--------KQ--------LF-----------WML----DIIGVLLMGCSLGCILVPLTLAGG------VKT----TWND------SRLIGPFVLGFVL-I-PVLWI--WE-Y-------------------R-----FAR-D----------P-ILPYKLV-KDRAVWSSMGISFLIDFIY-YMAADYLYTVMIVAVNESVKSATRISTLSSFVSTV-ASPFFALLVT-R---------CTRL-KPFIMFGCSL-WMVAMGLL----YHFR----------------------------GG--S------QSH--SGIIGALGVWGVGTTLFTY-PVTVSVQSAVS-HE------NMATVTALNYTLYRIGSAVGSAVSGAI-W--TQTL-YKQILKRMGD------------------------VALATAAYDSPYT------FIE--TYTWGTPQRVALMNA-YKYVQRLENIVALVF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Candida_guilliermondii_ATCC_6260_cagu_01265 -----------------------------------------------------------------------------------------------------------------------------------------------------------MSSEDSEK----------------------------------------------------------------------------------------------------KVFVEADAGDGTNREEHHLHGTQLMMCILSVFLCLFLFALDQTIVATILTTVGNKFD------GFDR--IGWLSSGFLLSTAVLVPSWGKVAMV-FGRKITMYAAILIFEAGSLMCALSN-----NMNTLIGGRVLAGVGGGGVQSLSFVITSEVVPIE--RRPFAMAAMGCTFAVAS--VLGPLVGGAFTD--N--V---SWRW-CF---YINLPIGAVAAIALFFSF-------KPP-----------K--------------------------------------------------------------------------------------TKGSI--------RE--------KL-----------KLI----DYWGTFLFTSGLVVLLLAITFGSG------NEY----AWNS------AAIIVCFILGTLA-L-IVWCI--YN-F-------------------R-----FSK-N----------P-LLPWEAV-RIIQVSAPALTLFCTYGSF-MSGILYISIYFQVIHGANAWRSGVDLLPFIIASVV-SSVSSGIVIA-K---------SRFV-KPFVVVAGSF-GPLGYGLL-----TLL----------------------------KV--D------SST--SSKIGLLILPGVCTGIQTQ-ASIIASQVSAP-KSPG----GMIYATTYINFARATGGALASALSTTV-Y--SSAL-KNALSSHLKN---------ASNDI------QQQLSSVPTDTLVNSTE------LIK----TLSPEARAFVKDQ-VMWAIERVFYMTVGFASLGFIA--CLFATN---H---RL-----PKK-----------------------------------SMGASAAETKEEEQEGLTNCDSQPTPVDRENVKNVESSG------------------------------------------------------------------------ Kluyveromyces_thermotolerans_CBS6340_klth0c10142g -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRKLSLVLCLTSLALTLFLAALDIVIVITLYETIGEKFK------DYAR--IGWLVTGYALPNALFTLLWGRLASI-LGLKTSLTFSIVIFEIGSLIVAVSN-----SMGMIIGGRVVAGCGGSGIQSLVFVVGTSLVEER--NRGMVITVLGLAFAVAF--AVGPVIGGAFTE--N--V---SWRW-CF---YINLPIGGVALTMLTFSY-------NTT----------EK---------------------SVQETLTYNCRQLQTYRYGQWVTASF---------------------------------------WRRAY--------NF--------LM-----------FDL----DFIGFALSSTGFVLFMLGLTFGG-------NTY----AWNS------GTIISFLTVGAIL-V-LFWLV--FD-FVLLYKWAAWCR--------K-----REA-T----------P-LLRRSLC-FRPGIFTSSIANLFTCFGF-NMQTVYIVQLYQLVFNSGPTAASMHLWAFLIATMV-SVIIIGKAAA-I---------FGLI-KPAIVFGATC-GLVGSGLM-----TLV----------------------------RN--T------STT--GNVIGYCILPGAAFGSIMQ-GTLLSAQVQVD-HDDENFQTMFIEATALNTFVKSLGFSFGGVVATMI-F--TNSV-KNQ----LRS---------TSAGV----AAFSSVEALIAY-RGQNYD-------------GPGSTLSLMFVKA-----IKDVMYAALGCYGIVFIA--SLFTSN---R---RL-----RLP--------------------------------SKNDGVEATAQEKSISGGDKSQLAPQSTSENDEN-------------------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0a07480g -----------------------------------------------------------------------------------------------------------------------------------------------MPSEQGALLSSKVGSSVDYS----------------------------------------------------------------------------------------------------SVPPTPRGNFEPNVQKPWIDRYRIVFIETALFANVFLSGLDGTITASTYQLIGNEFD------NFEI--SNWITTAYLVATTSFQPLYGSFSDT-LGRRHCLFFANTVFALGCLGCGLAP-----GILSLIFMRALTGIGGGGLITLSTIVNSDIIPPE--SRGIYQAFQNVLLGIGA--VIGASTGGAVAS--Y--L---GWRW-CF---LLQVPVSVGGTIMAYMFL-------ENQ--------------------------------------------------KGFVSESES---------------------------------------SGQLL--------KN--------RF-----------SKI----DLKGSLLLIVGLASQLMYLTVNS-------SMASSGSQWLS------KESIGLILLTVLS-L-VMFIH--TE-R-------------------T-----TQA-N----------P-IIPTKLL-SQSHSTMVLVISVLVGFVS-YAYLFTLPLFFQIVVGDSAARAGFRLAIPSFCTPI-GGLITGLSMR-----------IPKTLPFLLSFGMVL-MMIGNAFF-----LLL----------------------------KT--T------TPE--WLVCLLLTPANVGQGVTFP-ATLFSFLFSFH-PE------NQATATSTLYLFRSIGSLWGVAGTSGL-I--QLLV-GRK----IRE-----KLHGILSPE--------EIARLRSK-IGHKTS------YIE----KLPSEIKEAVVES-YESAIKFAHILSVSFCVIAIGI--SIVRHF--------------SKG-----------------------------------------------YRNLKEHNDPDLESPDRRNSVSLL--------------------------------------------------------------------------- Kluyveromyces_thermotolerans_CBS6340_klth0e16720g -------------------------------------------------------------------------------------------------------------------------------------------------MSVLGQNPNERKNVPPSY----------------------------------------------------------------------------------------------------SSISREEQMFSLTERPSWSERHKVLLIETALFTNVFLSGLDSTISASTYQLIGNEFG------DVKL--SSWITTAYLITCTSFQPLYGSFSDT-LGRRHCLFFANTIFALGCFGCGTTT-----TIYSLILMRALTGIGGGGLITLSTIINSDIIPAK--KRGIYQAFQNVLLGTGA--VVGASCGGLIAT--T--M---GWRW-CF---LLQVPISVGGTLVAFFFV-------HDQ-------------------------------------------------RPDINGGVSA---------------------------------------VRTTG--------WE--------KL-----------EKI----DFSGALLLVLGLACQLFFLTLNS-------TSKSSESYWYS------PQSIVLTLSTGVS-L-ILFAY--VE-H-------------------T-----TKA-N----------P-IIPHDLL-RQAHGATVLIISVLVGFVA-YAYIFTLPLYFQVVIGDTAAKAGLRLTVPSFCTPI-GGLITGLSMK-N---------PNHL-PVLLISGITC-MLLGNLCF-----LFI----------------------------KP--W------TPY--WQTSLLLVPANVGQGITFP-STLFTFLFAFP-PY------KQATATSTLYLFRSVGCVWGVAGTSSL-I--QYAV-RNQAKKSLNG-----------------LLTEKEIRKLLLQ-LSHTTS------QIK----KLPPDVRSAVISS-YDNAIRQAYFLSVFLCTIAILL--SFLKRV---F---KK-----RDE-----------------------------------------------HEGQDSNETENMHIRRESFTSLI---------------------------------------------------------------------------- Candida_guilliermondii_ATCC_6260_cagu_04556 ---------------------------------------------------------------------------------------------------------------------MSLQPSILKDSTTMGSGVVAAELAAQEEGLISKQNLRSHSYGALLD----------------------------------------------------------------------------------------------------GEEAANDEEDASSPDNYALPRFKLYTVISSLFMAAFLAALDTTVVTTLLTVIASDLN------AIAN--ISWIATAYLLSCAAFQPLFGKLSDI-FGRKILLLLCCFFFAVGCLICVTD------SLAMLVLGRFITGWGGSGLTTLGTITLSDLIPLR--DRGLYQGMANIFFGLGA--AFGGIFGGIVAD--W--L---GWRY-VF---LLQTPLAGAVGLALWWNL-------QLP---------------------------------------------------EGSPGLG----------------------------------------AKGDI--------RD--------KL-----------KRV----DFQGSFFLVSALMCIMAAASFGG-------DVL----AYSS------PYFIGLCVVSLVF-L-AAFVY--TE-L-------------------Y-----VSD-E----------P-ILPIELL-TERTILSSSLTNWFVTMGV-FANLFYVPVFFTSVMGYSATQSGMRMIPNFIGVSV-GSVGAGLVMK-H---------TGRY-YRLNVGAGFL-TVLGAILI-----VTV----------------------------PA--D------ASI--LRQYSLFAPSGLGYSCILT-VTLLALIAAVP-MK------YQACTTSIQYTFRSTGSTLGVSIASAI-F--QSIL-RSN----LNS-----KVSSVVSDA-------KTAHKIIKK-ALENTN------YVN----KAPLVAQKAILES-YYAACKGAFGFSVTVITIGVFC--SWFMKE---H---KL-----HSS-----------------------------------------------LDRE----------------------------------------------------------------------------------------------- Candida_lusitaniae_ATCC_42720_calu_04865 ---------------------------------------------------------------------------------------------------------------------------------------------------------MSDPTEENAP----------------------------------------------------------------------------------------------------KAYFESDAGDGTKREEMYLEGKELILCFVAIFACFFLFALDQTIIATLLTTVGNKFN------AFDK--IGWLSAGFLISMAVLVAVWGKLSII-FGRKITMMVAIVLFEAGSLMCALAS-----SMNILIGGRVLAGIGGGGVQSIAFIIVTEILPIQ--KRPMGMAILSTVFAVAS--VLGPLIGGAFTS--H--V---TWRW-CF---YINLPVGGAAFSLFVFVY-------NPP-----------K--------------------------------------------------------------------------------------AKGSI--------RE--------KL-----------KSI----DYPGVLLLSAGLVVFLLALTFGAG------GQY----AWNS------AAVITCFVVGGAV-S-IIFFI--WN-V-------------------W-----FSK-H----------P-MLPWEVL-RVFQIEASALALFGSYASF-ISAILYLSVYFQVIHDANAWKSGVHLLPLIISVVL-FSFSSAIACK-----------VTRYVKPFVVFGAFL-AMIGAGLL-----CLL----------------------------DV--N------SSS--SKKIGLLIPLGVGMGCLMQ-ACMLSAQIPAP-KTPG----GTILATTFANLLRSFGGALAANLADAV-Y--SASY-LNKVHHNLKK---------QPDEI------VKELSTIDIRAIVNSTA------AIS----KLSAPAQKFLKAQ-LMSAIKNIFYMSLGFSAIAVVA--SCFITN---K---RL-----PKA---------------EP---------------QERDEKNAEPEAARDDSVEAAENDSVEANTKDESSATE---------------------------------------------------------------------------- Kluyveromyces_thermotolerans_CBS6340_klth0d05434g ----------------------------------------------------------------------------------------------------------------------------------------------------MSGSPPGEDTALLGS----------------------------------------------------------------------------------------------------ISEENECDVGLEREYHEHNLALPKIPILVSLWLGSFLVALDGTIVANVMNRIAEEFQ------ESDK--KQWIATSFLLTNTAFQPLYGKLSDVATGRKLATLIAQFFFFLGLIISCFAQ-----NVTQFAIGRAVCGIGGGGVSAMSSIAVSDICTAK--ERGMYQGYANIVFGSGQ--LLGAPLGGLLIT--T--I---GWRA-IF---AIQVPMALFCMFLTGRNV--NIKLAHLP----------SR--------------------------------------------------------------------------------------NERFT--------LK--------NL-----------SRL----DLLGSCTLVLSISGLLFLFSTS--------MNR----TWIS------AFTIVTF---------AIFIY--NERF-------------------------WAK-E----------R-IIPFDLL--CGTSGITSLLTVLSSFIM-FGDVFRSPIYLQIVQNVSLAKSGIFILFGSVACAA-TSVLTGWIIR-R----TTMDLVKCT-YLIVLVMIFL-QLVGTASN-----AILIANLIPNNTTYADKD--VAIKVAL----SA--K------GFTWKVVYVFSTVLNSFGYGGVLV-AVLVSIVFTVP-KS------QQATLTGVFYLWRSIGNVLGTSITLAL-Y--DLIL-KSK----LRV-----FMEAHG------------LSKSYSK-LVRDSG------YLR--N-HFSGETLAELLGV-YNESFLWSFGPNIVVGLVAVIL--AYVLVR-------KY-----RPL-----------------------------------------------EQQGVHLAAGERSDACKH--------------------------------------------------------------------------------- Zygosaccharomyces_rouxii_CBS_732_zyro0a00330g -------------------------------------------------------------------------------------------------------------------------MDGEIAQPLLTRTVSSSNKQTNADKINQHYLSISHSDVGEYR----------------------------------------------------------------------------------------------------EEPNDDEQGDLDDETTPLSRIPHLWLIEAALYTNVFLSGFDSTVTASTYQTIGNEFN------HMDL--SSWITASYLITSTSFQPLYGSFSDV-LGRRKCLFFASMIFSIGCLGCGISI-----NILWLSFMRAFTGIGGGGLITLSTIVNSDMIPTS--KRGIFQAFQNLLLGLGA--ICGASFGGVITS--S--I---GWRW-CF---LLQVPISLAGALIGHLYV-------RNQ---------------------------------------------------DEYERRKSK--------------------------------------ESSQT--------KE--------ML-----------KHI----DFSGAFLIIIGLTLQLVYLSLGS-------AADESGNTWSS------PGLSAVLVASFIV-L-VLFVL--TE-E-------------------R-----TSA-R----------A-IIPSKLV-RSLFSFLVLTISVLVGFAS-YAYLFTLPLFFQVILGDSTAKAGLRLAIPSVFTPV-GGLIAGICMS-K---------FNCL-QTLLYVGIAF-MCLGNFLF-----LYI----------------------------GA--D------ATD--SLIGFFLIPANLGQGITFP-SSLFTFIFAFS-KI------DQATATSTLYLFRSIGSVWGVTGSAGI-V--QFCF-SHHLEKALEG-----------------LLDERKIRKLIKK-ITSNTS------YIK----ELEGPVKVAVIES-FDTATKKVHLISTSFCLVALIL---CVIKD----------------------------------------------------------------VFKPKTTKS------------------------------------------------------------------------------------------ Zygosaccharomyces_rouxii_CBS_732_zyro0g21890g --------------------------------------------------------------------------------------------------------------------------------MSTDQETVQNIELTSFDKSGAKVSSQYPLDEESYP----------------------------------------------------------------------------------------------------YEGEIEVGVAEEEDLEEDLRDSNFSWVLTSIWTNSALAALDGTIVSTTVNDIASQFQ------QASM--VTWVATAYLLTTTAVQPLYGKISDI-IGRRKCLLFGEVIFALGVLLCNFAN-----TIPQLAIARAICGIGGSGNSAMGNIMLNDILPLS--VRATYWSYGAILASIFQ--SLGGPIGGLLLK--W--F---GVGG-LF---TPQIPFCIGSIYLSYKYI--------HD--------------------------------------------------------------------------------------------------YKEHA--------RS--------SW-----------KRI----DFGGSICLLVGISSFIFFFSASD-------NTTIEDDGWST------PKKWSVVLLIVSI---IAFAF--IE---------------------N-----FVAVE----------C-IIPRVIL---EGTLGLMVCIHGLVAVINYTCLFMVPLFLQLNWGVSVSRSGGYIMFIVIFSSA-GSLFTSMILN-RFSKPTRSSQLFCA-ASAIFYMSIL-TIVGYYYMQKAIYYSK----------------------------PI--YGSDTQIPKYDNWSIILGIAILGFCQGSQNV-TISIYNVAKVG-RK------EQASSTSVNLLFRSMGNVLSVSIALNI-F--TNVL-KKKLSIVLND------------------------DLDLLAVLLKDNA------FLR--SDIMPTERIGPILGA-FHDALGTSIVPCKWCVYISLILSLMLFVTEYRQH----------KDL-------------------------------------------------------------------------------------------------------------------------------------------------- 'Kluyveromyces waltii NCYC2644 klwa 074-snap.3' ---------------------------------------------------------------------------------------------------------------------------------------MSNSAS--------TERGWIDQKKVPRS------------Y---------------------------------------------------------------------------------------ASIQTEETTTEPLAPSSWTERNRILLIETALFTNVFLSGLDSTITASIYQLIGNEFE------DVKV--SSWITTAYLVTCTSFQPLYGSFSDT-LGRRRCLFFANTIFALGCLGCGLTS-----TIYSLIIMRAVTGIGGGGLITLSTIVNSDIIPAK--KRGMYQSFQNILVGTGA--VVGASCGGEIAS--S--M---GWRW-CF---LLQVPISIGGAVMAYLFV-------QDQ--------------------------------------------------DVVDKNPRSGAL------------------------------------PSNVS------------------KI-----------KKI----DFLGAFLLISGLVSQLIFLTINS-------SAQEGKSTWLS------GRSLALGLVTAVS-L-ILFAY--VE-K-------------------T-----TTA-N----------P-IIPHDLL-GQWYSTTVLIVGVLVGFVS-YAYIFTLPLYFQVVVGDTAAEAGLRLTVPSFCTPI-GGVIMGISMK-D---------PKRL-PGLLIVGISL-MLFGNLCF-----LLI----------------------------KP--T------TPY--WLTSLLLVPANIGQGITFP-STLFSFLFAFP-PY------KQATATATLYLFRSVGCVWGVAGTSSL-I--QSVV-RKQATKRLQG-----------------ILTDEEIKSLLVK-LSHKTS------LIE----KLPDNVRAAVLTS-YEISIKSTYFFSVILCLIAIIL--ALMRRV--FK---KF-----DGT-----------------------------------------------NDRDLEEREDLTNRRDSFASLL----------------------------------------------------------------------------- Kluyveromyces_lactis_CLIB210_klla0a04631g -------------------------------------------------------------------------------------------------------------------------------MVESDRTSLLQPVRNALNPELSEGLPAYVGAEVAET----------------------------------------------------------------------------------------------------EHLLESEDEAREGLQVSEMSRARLHIIISSMCLGSFLAALDNTIVTTLLSHIASEFN------ELSH--ISWIATAYLLSSATFQPLYGKISDI-FGRRPLIIISNLFFILGCLICGLSK-----NLWTLVAGRFIAGIGGGGVTSLGSITASDIVPLR--SRALYQGIFNFFFGLGI--AIGGLIGGWFSESKN------GWRM-AF---LVQVPLCAISLVLIIIFL-------KLP----------PG-----------------------------------CKGLGLVSNDKD---------------------------------------GKVDI--------KD--------KL-----------KRI----DWLGSLSLVTFLFAFMLASSLGG-------KEI----PYNS-------NIFKLLVVATILSG-TAFIY--VE-L-------------------Y-----ISD-D----------P-ILPIRFL-TNRSILGASFANWFCMMSG-VTLAFYVPVYWSSVQNLKPTDMGKRIAPNFFSTAF-GSIGAGYYMK-K---------TGRY-YGFLLKFTGL-MVLGQLQV-----LLM----------------------------KP--D------IST--WRQYILLPLPHFGSSVLIT-VTLLAMIAAVP-HE------HQAATTSISYAFRSTGSTLGVSVGAAL-F--RNKL-SGS----LFD-----SVMKFESDK----YSKEYLLSIIKQ-ASESSE------YVH---ANAPKFIQATLIQC-YEQACKSTFAFCFLISIFAWIS--CGVIKE---Y---KL-----HTS-----------------------------------------------MERK----------------------------------------------------------------------------------------------- Candida_dubliniensis_CD36_cadu_43440 ------------------------------------------------------------------------------------------------------------------MTIQDHNSIHPNVIQDISTDAPGIVAGELAAEDEGLLSNNALKTHTYGS----------------------------------------------------------------------------------------------------VATQETHYEIDDPNGGYALPKAQLYTVVSSLFMASFLAALDGTVVTTLLTLIASELH------AVSN--ISWIATAYLLSSAAFQPIFGKLSDI-FGRKTLLLGCSTLFAVGCAICGIAD-----SVLVLVIGRFVTGCGGSGLTSLGTITMSDIIPLR--DRGYFQGLANIFFGLGA--ASGGAIGGLLAD--W--L---GWKY-VF---ILQVPLALSVFFAIYFFL-------NLP----------EG-----------------------------------------SPGLGM----------------------------------------EGNV--------SE--------KL-----------KRV----DFLGSFFLVSSLMVFLSAASLGG-------REI----AYSS------FTFIGLSISALAL-L-AAFVA--VE-L-------------------Y-----VSQ-E----------P-ILPIELF-ANRTVLASSLTNWFYTMAI-FTTLFYVPIYYSSVIGLTPTQNGMRLVPNFFGVSF-GSVGAGIYMK-K---------TGRY-YKLAVVAGVL-AIFGVAKI-----VLL----------------------------TP--N------IPT--WQQFLLLIPSGLGYSCILT-VTLLALIAAAP-LK------YQACTTSIQYTFRSTGSTLGVSAATAV-F--QNVL-LHQ----LTN-----KINKLVTDP-------KEAAKIIAK-ALDSTE------YVN----EAPKYVREVIRAS-YDAGCKGAFGFAFATIVLGVIS--SLFMRE---H---VL-----HTS-----------------------------------------------INRD----------------------------------------------------------------------------------------------- Saccharomyces_mikatae_IFO_1815_sami_a_c124_14118 ---------------------------------------------------------------------------------------------------------------------------------------------------------MGEEKNSSQA----------------------------------------------------------------------------------------------------EVKAYESDTELNVNSSDERGGISLYLCLTSLTLVLFITALDILIVGTIIDVVAEQFG------NYSK--TGWLVTGYSLPNAILSLVWGRFASI-IGFQHSLILAVLIFEAGSLVAALAN-----SMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVNER--SRPLVISILSCAFAVAA--IVGPIIGGAFTT--H--V---TWRW-CF---YINLPIGGFAVIMFLLTY-------KTK----------SE-----------------------------NILQQTRNILGRISKFELRRLTEPGN-------------------------------LRKAL--------IG--------IL-----------FKF----DFLGFALSSAGLVLFLLGLTFGG-------NKY----SWNS------GQIITYLVLGILL-F-VFSLI--YD-FFIFQKFNPEPD--------N-----TSY-R----------P-LFLKRLV-AKPAVIIVNMVTFLLCIGY-NGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVI-AAIASGVITK-K---------LGLV-KPLLIFGGIL-GVIGAGLM-----TLM----------------------------SN--N------STS--STQIGVLILPGLSLGFALQ-ASLMSAQLQIK-KDRPEATTDFIEITAFNTFMKSLGTTLGGVLSTTV-F--SASL-RNK----VKH---------AQLEM----YVGKTVDDMILY-RLQNFD-------------GPHSSIGNILSDS-----IKNVFWMDMGFYALGFIF--CIFSSN---R---RL-----VIP-----------------------------------------------KKDIPSEESVESN-------------------------------------------------------------------------------------- Saccharomyces_mikatae_IFO_1815_sami_b_c2470.1 ---------------------------------------------------------------------------------------------------------------------------------------------------------MGEEKNSSQA----------------------------------------------------------------------------------------------------EVKAYDSDTELNVNSSDERGGISLYLCLTSLTLVLFITALDILIVGTIIDVVAEQFG------NYSK--TGWLVTGYSLPNAILSLVWGRFASI-IGFQHSLILAVLIFEAGSLVAALAN-----SMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVNER--SRPLVISILSCAFAVAA--IVGPIIGGAFTT--H--V---TWRW-CF---YINLPIGGFAVIMFLLTY-------KTK---------------------------------------SENILQQTRNILGRISKFELRRLTEPGN-------------------------------LRKAL--------IG--------IL-----------FKF----DFLGFALSSAGLVLFLLGLTFGG-------NKY----SWNS------GQIITYLVLGILL-F-VFSLI--YD-FFIFQKFNPEPD--------N-----TSY-R----------P-LFLKRLV-AKPAVIIVNMVTFLLCIGY-NGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVI-AAIASGVITK-K---------LGLV-KPLLIFGGIL-GVIGAGLM-----TLM----------------------------SN--N------STS--STQIGVLILPGLSLGFALQ-ASLMSAQLQIK-KDRPEATTDFIEITAFNTFMKSLGTTLGGVLSTTV-F--SASL-RNKVKHAQLE-----------------MYVGKTVDDMILY-RLQNFD-------------GPHSSIGNILSDS-----IKNVFWMDMGFYALGFIF--CIFSSN---G---RL-----VIP-----------------------------------------------KKDIPSEESVESN-------------------------------------------------------------------------------------- Candida_albicans_SC5314_caal_a_19.1308 -----------------------------------------------------------------------------------------------------------------MTIQDHNTIHPNVIQDVSTEAPGIVAGELAAEDEGLLSNDALKTHTYGSV----------------------------------------------------------------------------------------------------STPETTHYEIDDPNGGYALPKTQLYTVVSSLFMASFLAALDGTVVTTLLTLIASELH------AVSN--ISWIATAYLLSSAAFQPIFGKLSDI-FGRKALLLGCSTLFAVGCAICGAAD-----SVLVLVIGRFVTGCGGSGLTSLGTITMSDIIPLR--DRGYYQGLANIFFGLGA--ASGGAIGGLLAD--W--L---GWKY-VF---ILQVPLALSVFFAIYFFL-------NLP----------EG-----------------------------------------SPGLGM----------------------------------------EGNV--------SE--------KL-----------KRV----DFLGSFFLVSSLMVFLSAASLGG-------REI----AYSS------FTFIGLIISAFVL-L-TAFVA--VE-L-------------------Y-----VSE-E----------P-ILPIELF-ANRTVLASSLTNWFYTMSI-FTTLFYVPIYYSSVIGLTPTENGLRLVPNFFGVSF-GSVGAGIYMK-K---------TGRY-YKLAVLAGIF-AIFGIGKI-----ALL----------------------------TP--N------IPT--WQQFLLLIPSGLGYSCILT-VTLLALIAAAP-LK------YQACTTSIQYTFRSTGSTLGVSAATAV-F--QNVL-LLQ----LTK-----KINELVSDP-------REAAKIIAK-ALDSTE------YVN----EAPKYVREAIRAS-YDAGCKGAFGFAFATIVLGVIS--SLFMRE---H---VL-----HTS---------------------------------------------------INRD------------------------------------------------------------------------------------------- 'Candida albicans WO-1 caal b 03443' -----------------------------------------------------------------------------------------------------------------MTIQDHNTIHPNVIQDVSTEAPGIVAGELAAEDEGLLSNDALKTHTYGSV----------------------------------------------------------------------------------------------------STPETTHYEIDDPNGGYALPKTQLYTVVSSLFMASFLAALDGTVVTTLLTLIASELH------AVSN--ISWIATAYLLSSAAFQPIFGKLSDI-FGRKALLLGCSTLFAVGCAICGAAD-----SVLVLVIGRFVTGCGGSGLTSLGTITMSDIIPLR--DRGYYQGLANIFFGLGA--ASGGAIGGLLAD--W--L---GWKY-VF---ILQVPLALSVFFAIYFFL-------NLP----------EG-----------------------------------------SPGLGM----------------------------------------EGNV--------SE--------KL-----------KRV----DFLGSFFLVSSLMVFLSAASLGG-------REI----AYSS------FTFIGLIISAFVL-L-TAFVA--VE-L-------------------Y-----VSE-E----------P-ILPIELF-ANRTVLASSLTNWFYTMSI-FTTLFYVPIYYSSVIGLTPTENGLRLVPNFFGVSF-GSVGAGIYMK-K---------TGRY-YKLAVLAGIF-AIFGIGKI-----ALL----------------------------TP--N------IPT--WQQFLLLIPSGLGYSCILT-VTLLALIAAAP-LK------YQACTTSIQYTFRSTGSTLGVSAATAV-F--QNVL-LLQ----LTK----------KINE--LVSDPREAAKIIAK-ALDSTE------YVN----EAPKYVREAIRAS-YDAGCKGAFGFAFATIVLGVIS--SLFMRE---H---VL-----HTS-----------------------------------------------INRD----------------------------------------------------------------------------------------------- Candida_lusitaniae_ATCC_42720_calu_02516 ------------------------------------------------------------------------------------------------------------------------MSSSKESNDGSLHGSSSIENNPPIISRTETRTTAPADELPYGR----------------------------------------------------------------------------------------------------SETVQNLEDKLGDSHVNLLPKKKLIICLMGMSLSLFACFCDQTSVTVALPYIAKDLH------ATDS--INWAGTSALVANCVSQVLFGRFADI-FGRKTVLLFSLCLLMISNMLCGFAQ-----TAVQFYIFRAFAGIGAGGTQSLTMVIVSDIVTLR--QRGKFQGILGANVGLGN--AVGPLIMGVYTE--K--L---SWRY-FY---RTLPPIVAVVTVTVYLLV-------DNK------------------------------------------------------KPHSH---------------------------------------SVLTT--------KE--------KF-----------QKI----DYYGIVFAMAGLLLLLIPISGGG-------STY----KWNS------PIVIVMFCVGGVC-L-IIFLLIEWK---------------------------IPE-L----------P-MIPLQLF-QNRSLCILLGTTFLNGAAY-FGFLFIVSYYYELVKGGSPMRSAVLMLPLVLTQAT-MSSIAGTIIS-Y---------IGHF-LPIMYSGYSF-WLTGCGMT-----VAW----------------------------KE--D------TST--AYIAGTLIMLGTGIGFIFQ-PTMVAAQANSR-MS------QRAVVISTRNVLRSFGAAFGTAICSLI-I--TNTL-VTEINKKMNE----------------GGASMSYLSSLKKNIYSRPDT------------ANLTEAQLHVVRSL-YMKAIRNVFYLTIPLVSICLLS--TFFVKD---N---GL-----QCL-----------------------------------------------DEVPKATEEKNASE------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_S288C_sace0k07392g -------------------------------------------------------------------------------------------------------------------------------------------------------MEETKYSSQQEI----------------------------------------------------------------------------------------------------EGACGSDASLNARGSNDSPMGLSLYLCLASLTLVLFITALDILIVGTIIDVVAEQFG------NYSK--TGWLVTGYSLPNAILSLIWGRFASI-IGFQHSLILAILIFEAGSLIAALAS-----SMNMLIFGRVVAGVGGSGLQTLCFVIGCTMVGER--SRPLVISILSCAFAVAA--IVGPIIGGAFTT--H--V---TWRW-CF---YINLPIGGLAIIMFLLTY-------KAE----------NK-----------------------------GILQQIKDAIGTISSFTFSKFRHQVN-------------------------------FKRLM--------NG--------II-----------FKF----DFFGFALCSAGLVLFLLGLTFGG-------NKY----SWNS------GQVITYLVLGVLL-F-IFSLV--YD-FFLFDKFNPEPD--------N-----ISY-R----------P-LLLRRLV-AKPAIIIVNMVTFLLCTGY-NGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVI-AAIASGVITK-K---------LGLV-KPLLIFGGVL-GVIGAGLM-----TLM----------------------------TN--T------STK--STQIGVLLLPGFSLGFALQ-ASLMSAQLQIT-KDRPEAAMDFIEVTAFNTFMKSLGTTLGGVLSTTV-F--SASF-HNK----VSR---------AHLEP----YEGKTVDDMILY-RLQNYD-------------GSHSTIGNILSDS-----IKNVFWMDLGFYALGFLF--CSFSSN---K---KL-----IIP-----------------------------------------------KKDDTPEDNLEDK-------------------------------------------------------------------------------------- 'Saccharomyces cerevisiae RM11-1A sace d 05344' -------------------------------------------------------------------------------------------------------------------------------------------------------MEETKYSSQQEI----------------------------------------------------------------------------------------------------EEACGSDASLNARGSNDSPMGLSLYLCLASLTLVLFITALDILIVGTIIDVVAEQFG------NYSK--TGWLVTGYSLPNAILSLIWGRFASI-IGFQHSLILAILIFEAGSLIAALAS-----SMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGER--SRPLVISILSCAFAVAA--IVGPIIGGAFTT--H--V---TWRW-CF---YINLPIGGLAIIMFLLTY-------KAE-------------------------------------------------NKGILQQIKDAIGTISSFTFSKFRHQVN---------------------FKRLM--------NG--------II-----------FKF----DFFGFALCSAGLVLFLLGLTFGG-------NKY----SWNS------GQVIAYLVLGVLL-F-IFSLV--YD-FFLFDKFNPEPD--------N-----ISY-R----------P-LLLRRLV-AKPAIIIINMVTFLLCTGY-NGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVI-AAIASGVITK-K---------LGLV-KPLLIFGGVL-GVIGAGLM-----TLM----------------------------TN--T------STK--STQIGVLLLPGFSLGFALQ-ASLMSAQLQIT-KDRPEAAMDFIEVTAFNTFMKSLGTTLGGVLSTTV-F--SASF-HNK----VSR---------AHLEP----YEGKTVDDMILY-RLQNYD-------------GSHSTIGNILSDS-----IKNVFWMDLGFYALGFLF--CSFSSN---K---KL-----IIP-----------------------------------------------KKDETPEDNLEDK-------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_YJM789_sace_e_0518 -------------------------------------------------------------------------------------------------------------------------------------------------------MEETKYSSQQEI----------------------------------------------------------------------------------------------------EEACGSDASLNARGSNDSPMGLSLYLCLASLTLVLFITALDILIVGTIIDVVAEQFG------NYSK--TGWLVTGYSLPNAILSLIWGRFASI-IGFQHSLILAILIFEAGSLIAALAS-----SMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGER--SRPLVISILSCAFAVAA--IVGPIIGGAFTT--H--V---TWRW-CF---YINLPIGGLAIIMFLLTY-------KAE----------NK-----------------------------GILQQIKDAIGTISSFTFSKFRHQVN-------------------------------FKRLM--------NG--------II-----------FKF----DFFGFALCSAGLVLFLLGLTFGG-------NKY----SWNS------GQVIAYLVLGVLL-F-IFSLV--YD-FFLFDKFNPEPD--------N-----ISY-R----------P-LLLRRLV-AKPAIIIVNMVTFLLCTGY-NGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVI-AAIASGVITK-K---------LGLV-KPLLIFGGVL-GVIGAGLM-----TLM----------------------------TN--T------STK--STQIGVLLLPGFSLGFALQ-ASLMSAQLQII-KDRPEAAMDFIEVTAFNTFMKSLGTTLGGVLSTTV-F--SASF-HNK----VSR---------AHLEP----YEGKTVDDMILY-RLQNYD-------------GSHSTIGNILSDS-----IKNVFWMDLGFYALGFLF--CSFSSN---K---KL-----IIP-----------------------------------------------KKDETSEDNLEDK-------------------------------------------------------------------------------------- 'Saccharomyces paradoxus NRRL Y-17217 sapa c403 13057' -------------------------------------------------------------------------------------------------------------------------------------------------------MKETKYSSQPEI----------------------------------------------------------------------------------------------------EEACDSDASLNAKSSNDPPMRLSLYLCLASLTLVLFITALDILIVGTIIDVVAAQFG------NYSK--TGWLVTGYSLPNAILSLIWGRFASI-IGFQHSLVLAILIFEAGSLIAALAS-----SMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGER--SRPLVISILSCAFAVAA--IVGPIIGGAFTT--H--V---TWRW-CF---YINLPIGGLAIIMFLLTY-------KGE----------NK-----------------------------SILQQTKDIMGKISSFEFGKFRKQVN-------------------------------SKRVM--------NG--------II-----------FKF----DFFGFSFCSAGLVLFLLGLTFGG-------NKY----SWNS------GQVITYLVLGTLL-F-MFSLV--YD-FFIFNKFNPEPD--------N-----ISY-R----------P-LLLKRLI-AKPAVIIVNMVTFLLCTGY-NGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVI-AAIASGVITK-K---------LGLV-KPLLMFGGFL-GVIGAGLM-----TLM----------------------------KN--N------STR--STQIGVLLLPGFSLGFALQ-ASLMSAQLQIN-KDHPEASMDFIEITAFNTFMKSLGTTLGGVLSTTV-F--SASL-HNK----VSQ---------ARLEP----YVGKTVDDMILY-RLQNYD-------------GSHSTIGNILSDS-----IENVFWMDLGFYALGFLF--CIFSSN---K---KL-----IIP-----------------------------------------------KKNPTPEDNIEDK-------------------------------------------------------------------------------------- 'Saccharomyces paradoxus NRRL Y-17217 sapa c84 2187' -------------------------------------------------------------------------------------------------------------------------------------------------------MKETKYSSQPEI----------------------------------------------------------------------------------------------------EEACDSDASLNAKSSNDPPMRLSLYLCLASLTLVLFITALDILIVGTIIDVVAAQFG------NYSK--TGWLVTGYSLPNAILSLIWGRFASI-IGFQHSLILAILIFEAGSLIAALAS-----SMNMLIVGRVVAGVGGSGLQTLCFVIGCTMVGER--SRPLVISILSCAFAVAA--IVGPIIGGAFTT--H--V---TWRW-CF---YINLPIGGLAIIMFLLTY-------KGE---------------------------------------NKSILQQTKDIMGKISSFEFGKFRKQVN-------------------------------SKRVM--------NG--------II-----------FKF----DFFGFSFCSAGLVLFLLGLTFGG-------NKY----SWNS------GQVITYLVLGTLL-F-MFSLV--YD-FFIFNKFNPEPD--------N-----ISY-R----------P-LLLKRLI-AKPAVIIVNMVTFLLCTGY-NGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVI-AAIASGVITK-K---------LGLV-KPLLMFGGFL-GVIGAGLM-----TLM----------------------------KN--N------STR--STQIGVLLLPGFSLGFALQ-ASLMSAQLQIN-KDRPEASMDFIEITAFNTFMKSLGTTLGGVLSTTV-F--SASL-HNKVSQARLE-----------------PYVGKTVDDMILY-RLQNYD-----------------GSHSTIGNI-LSDSIENVFWMDLGFYALGFLF--CIFSSN---K---KL-----IIP-----------------------------------------------KKNPTPEDNIEDK-------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_EC1118_sace_b_1k5_3763g ----------------------------------------------------------------------------------------------------------------------------------------------------------------MYS----------------------------------------------------------------------------------------------------MTSTFFKLKENEIMSAQFDSLKYKILLISTAFVCGFGISLDYTLRSTYTGYATNSYS------EHSL--LSTVQVINAVVSVGSQVVYSRLSDH-FGRLRLFLVATIFYIMGTIIQSQAT-----RLTMYAAGSVFYNCGYVGTNLLLTLILSDFSSLK--WRMFYQYASYWPYIIIP-WISGNIITAANPQ--K------NWSW-NIAMWAFIYPLSALPIIFLILYM-------KYK----------SS-------------------------------------KTAEWRSLKEQARKERTGG------------------------------LFENL--------VF--------LF-----------WKL----DIVGILLITVSLGCILVPLTLANE------TSQ----KWHN------SKIIATLVSGGCL-F-FIFLY--WE-A-------------------K-----FAK-S----------P-LLPFKLL-SDRGIWAPLGVTFFNFFTF-FISCDYLYPVLLVSMKESSTSAARIVNLPDFVAAT-ASPFYSLLVA-K---------TRKL-KLSVIGGCAA-WMVCMGLF----YKYR----------------------------GG--S------GSH--EGVIAASVIMGLSGLLCSN-SVIVILQAMTT-HS------RMAVITGIQYTFSKLGAAIGASVSGAI-W--TQTM-PNQLYKNLGN------------------------DTLAEIAYASPYT------FIS--DYPWGSPERDAVVES-YRYVQRIIMTVGLACTVPFFAF--TMFMRD---P---EL-----IDK----------------------------------ATHEEFTEDGLVVLPDEENTFSQIKTLFRHNRSNKKSGC------------------------------------------------------------------------- Candida_guilliermondii_ATCC_6260_cagu_00118 -------------------------------------------------------------------------------------------------------------------------------------------------MSEANSMKKGTAAVEITN----------------------------------------------------------------------------------------------------IDSPNLAEKLGDAHMNILPARK-VIICLSALALGMIISFADQTGVTVALPHIGKELH------AETT--INWAGTASLLANCVCQVLFGRLSDI-FGRKQIMIGCLAILVVADLCCGFAQ-----TGVQFYIFRAFAGIGNGGVSSLSMVILSDVVTLE--QRGKFQGILGANVGVGN--AIGPFLMAAFVK--H--R---SWRD-FY---YLLAPMGLLVIIAVYFLV-------EDK----------QK--------------------------------------------------------------------------------------DSRLL------NYKE--------KF-----------QKI----DYFGILFATAGLTLLLIPISGGG-------STY----AWNS------PIVITMFVVGGVL-M-IVFLLIEWK---------------------------VPQ-L----------P-MIPLYIF-KRASLSLLLGSTFFFGMAY-FGFMYYVPYYFHVVKGRDIIHTSIFLLPLVLSQSI-MSIVSGQIIT-R---------TGHY-IYVVWAGYVM-WFVSCGLL-----ILW--------------------------------D------DKLSDGVNVVVLLLMGSGVGFTFQ-PTMVAAQAQSK-KA------DRAVVISTRNVLRSFGGAVGIAIGSTT-V--SNTF-LNNISSIEEN-------------------NVTNIPQSYFD-FLRKHI------YQTIDTTKLNPQQAEVVRRM-YVKALKNYFYLLIPFIGICLIC--SLFVRD---RGLQCI-----DEP------------------------------------TKEERDLGTEIEKTRYANSSHDLESTAGSNATVDSEATRTH--------------------------------------------------------------------- Candida_parapsilosis_CDC_317_capa_01507 ----------------------------------------------------------------------------------------------------------MSTEANTRNGQHNHHLYPNIIHDASADSAGIIASELAAEDGSLFNNSVLKSHSYGAT----------------------------------------------------------------------------------------------------ESETPESYEIDEPNGGYALPKKQLITVVSSLFMASFLAALDATVVTTLLAVIASELK------AVKN--ISWIATSYLLSSSAFQPIFGKLSDI-FGRRFILIGCSLMFGIGCTICVTD------SLWWLVIGRFITGWGGSGLTAVGTITMSDLIPLR--DRGLYQGLANICYGLGA--ASGGFVGGIVAD--T--L---GWKY-VF---ILQVPLAAIVGIAIYWNL-------NLP----------AG-----------------------------------------SPGLGA---------------------------------------HGQDI--------KQ--------KL-----------KRV----DFLGSFCLISALMLFLTATSMGG-------RDI----AFTS------NLFISLSVASFAL-I-LAFLY--VE-A-------------------Y-----VSE-E----------P-IIPIELL-GNRTVLASSLTNWFYTMGI-FAIMFYVPVYYTSVLYLTASENGLRLVPNFIGISM-GSVGAGLYMK-R---------TGRY-YNLAVAAGIL-AIYGAYRV-----TRL----------------------------DT--H------TPT--WQQFLMMLPQGMGYSCILT-ITLLALIAATP-MK------YQACTTSIQYTFRSTGSTLGVSAASAI-F--QTVL-GSS----LRK-----KIWDLVKDL-------EEAKKIIAR-ALDDTN------YVH----EAPKYVREAIRSS-YDEGCRGAYYFALIVLIIGVIS--SLFMRE---H---KL-----HTS-----------------------------------------------LNRD----------------------------------------------------------------------------------------------- Candida_guilliermondii_ATCC_6260_cagu_04884 -------------------------------------------------------------------------------------------------------------------------------------------------------MSSEDLEKKEKK----------------------------------------------------------------------------------------------------VFVEADAGDGTHREDHHLHGTQ-LMMCIFSVFLCLFLYALDQTIVATLLTTVGNKFD------GFDR--IGWLSSGFLLSTAVLVPSWGKVAMV-FGRKITMYAAIVIFEAGSLMCALSN-----NMNTLIGGRVLAGVGGGGIQSLAFIIISEVVPIE--KRPLSMAVMGCTFAVAS--VLGPLIGGAFTD--N--V---TWRW-CF---YINLPIGAVAAFVLFFSF-------KPP-----------K--------------------------------------------------------------------------------------TKGNI--------RE--------KL-----------KMI----DYLGTFLFTSGLVVFLLAITFGSG------NDF----AWDS------AAVIVCFILGTLV-L-IGWCV--YN-F-------------------G-----FSK-N----------P-LLPWEVV-RIIQVSAASLTLFCAFGSF-MSGIIYVSIYFQVIHGANAWHSGVDLLPFIIAVVI-SSIMSGIIIA-K---------SRFV-KPFTVIAGAL-GPLGYGLV-----SLL----------------------------EV--D------SSS--SSKIGLLIVPGVSTGMQMQ-ASMIASQVAAP-KTPG----GMIYATTYINVARATGGALASALSTAV-Y--SSAL-KDA----LSS-----HLKIAS-QD----IQRQLSSVPIDT-LVNSTE------LIK----TLSPEAQKFVKDQ-VMWAIKRVFYMALGFAGLGFIS--SLFATN---H---RL-----PKQ-------------SVGA---------------AAASSEPKEESKEESKEERLETDNDSSVTPVDGANEEKISRSSVEVKN------------------------------------------------------------------ 'Kluyveromyces waltii NCYC2644 klwa 281-snap.8' ----------------------------------------------------------------------------------------------------------MSPGERTSFLAPIDKDVIQDPSTGLAGFVANEVEQQDYNSRTGHDSYGATAVDDRTA----------------------------------------------------------------------------------------------------TSARCDLTFPPSETPEFALSSSRIRIIMISMFLGIFLAALDGTIVSTLLTRIGSEFN------SLDK--VSWIATSYLLSSSTCQPLYGKLSDQ-LGRKPLLVFSNVVFSIGCLICGMST-----SIWWVVVGRFVSGIGGCGLTCLASMVISDLVPLR--ERAVYQGLCNFIFGLGT--ASGGLVGAAFQD----------WRM-AF---TIQCPISLASCALIVSYL-------ELP----------PR------------------------------------------HEDDKDRH------------------------------------WTSKL-------------------------------RDL----DWAGVVTLVCFLFLFMLVSSLGG-------KEI----AYDS------VLFALLCVTTLVL-G-SIFAY--VE-L-------------------Y-----VAV-D----------P-VLPIAFL-KYRSVLGSSLANWFAMMSM-LTTNYYLPVYWASVLNMKPTDIGKRSIPSFFSVAF-GSLGAGIYMK-R---------TGKY-YWFLLAFCGI-GILGQLKI-----NLL----------------------------TP--A------TPV--WQQYLLLVVPSFGLSVLIT-VTLLAMISAVP-HE------HHAATTSISYAFRSTGATLGVSIGAAI-F--RSTL-NTL----LQN-----KVLQFASDE----HPREELLRIINN-AAHSAN------WVH---KEAPEFVRATLVEC-YHYASKSTFKFCLITMILAGAS--CSIIQE---H---TL-----HTT-----------------------------------------------LKRDK---------------------------------------------------------------------------------------------- Candida_lusitaniae_ATCC_42720_calu_04792 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKFLQSDAGDGTHAKDHYVHGMR-LVLILVSIVATLFISALDQTIVSTLLVDIATHFD------SFSR--VGWLTTGYMLPMTCLAPSYGKLAVA-FGRKYTLAAAIVIFEIGSLVAALST-----SMDMLIGGRVVQGIGGGAIQAVSVVVLSETVAIN--RRALAMSLIGVTFTVAS--VCGPFIGGAFAT--H--A---TWRW-CF---YINLPVGGAALALLWTVF-------RPP-----------P--------------------------------------------------------------------------------------PQGSI--------RA--------HL-----------REV----DWIGTCLVAAGLVLVLLALTWGG-------IEH----PWDS------AQVIVCFVIGGLV-L-VVWAA--WN-Q-------------------GIRPPALAS-I----------PALLDPRVV-LVPQILAAAASSSFAFAFF-MGLMNYLAIYFQVVHNASAWQSGVDMLPFIITVSV-ASALNGVFIR-----------FTYFIKVPFMASAIL-GPIGVGLL-----LLL----------------------------GR--H------VPL--GKRIGLLIPAGISVGLMFQ-SSLMSAQLKAPGHVPG----SMITATVFINFAKTLGGVIGVVTSQLM-L--MERG-ERY----LSA-----ARASSP-------ELASSLNAPISAVLQSPSL-----------IWHLPPTARDIVLDE-FLRALHDVFYLNLAFASMALVL--TIFSTN---E---RI-----PRG--------------------------------DQIAYNDDEEKADKSDEKASEHEGELRDHRESRPLTQIESQSSASPPLPTPTASPEKILL------------------------------------------------------ 'Kluyveromyces waltii NCYC2644 klwa 073-snap.6' -----------------------------------------------------------------------------------------------------------------------MKYSSFMNRIPNERTHLLDRTLEDGIGDSDMLNSDLKSTKIKHT------------QRHQLYHSNLDK----------------------------------------------------------------------------ARNGNDSATDFSSNNLSDLMSRRIFMISASMFLGIFLAALDNTIVSTLLPHIGSELN------DMPN--VSLVATSYVFSCAIFQPLFGKTSDV-FGRKPLLISSNLLFFAGCLTCGLSK-----TIWWLILGRLVTGIGGGGLTSMCTIIINDIVPLR--NRAVYQGFGNLFYALGT--ACGGLVGGLFSEYGN------GWRM-AF---MIQLPFCFLSTISIIVYL-------DLS---------------------------------------------------DDKQDLGR---------------------------------------SSLYC------------------KL-----------RLI----DWLGALTLVTFLLLFLVTMTIGG-------QHV----PYGS------LRFFLLCVAVCAS-G-LALAY--VE-I-------------------F-----LAN-D----------P-ILPISFL-RNKNVLGSSLANWFCMMGM-MTITYYLPIYWSSVSNQGPIQVGKKSIPSFFSMAL-GSFGTAYYVQ-K---------NGTY-YRLLMTSCLI-IIFGQLQI-----VYI----------------------------TP--E------MPQ--WRQYILLAVPGFGVSILIT-VTLLAMIAAVP-HK------HQAATTSLSYAFRTTGCIIGASLAGAI-F--QNTL-KKNVTTAVMK---------FLGDE----HSKKELNLVIEK-ALRSSD------WVN---NGSPEFVHEALLKC-YENACGQTFRFCLLCFLLTVIS--CSFITE---I---NL-----PTT-----------------------------------------------LGS------------------------------------------------------------------------------------------------ Zygosaccharomyces_rouxii_CBS_732_zyro0c01430g ----------------------------------------------------------------------------------------------------------------METNNSKNDLTSRTNFLNPVRDDILQDAS--------TDIPGFVAEELEER------------EELYRECQGTD-----------------------------------------------------------------------------YGSIDNEDDSRDGVASSPVPPDKLLVITLSMYLGIFLAAADGTLVSTIMAHIASEFN------ELPR--ISWIATAYLLSSATFQPLYGKLSDI-FGRKPLLMLNNIVFLVGCLMCGLTP-----SFWGLVGARFISGIGGGGVTSMCSITISDIVPLR--DRALYQGMCNFFFGLGT--ACGGVVGGWFSD--H-GG---GWRM-AF---LIQVPLSALSSLLIAVFM-------KLP----------PR------------------------------------------SKRVN---------------------------------------SPASI--------KN--------KL-----------LSV----DWIGASALVVFLSLFLVTASLGG-------KEI----AFNS-------KTFVALCIGSSLAC-AFFIG--VE-L-------------------Y-----GAK-D----------P-ILPLSFL-RNRSVLGSSFSNWFCMMAM-MTTSYYLPIYYSGVLNMNPTRVGKRLMPNFFSTAL-GSLGAGYYMK-R---------TGKY-YWLTVGFCTL-SLLGHLQI-----NLM----------------------------KP--D------IAT--WRQFILLVIPGFGYSVLIT-VALLAMIAAVP-HN------HHAATTSISYAFRSTGSTLGVSIGGAI-F--RQSL-NGL----LSR-----KVLKFA-DK----HPRKELLEIIEK-ASKSSE------WVH---DSAPEFIRPTLIGC-YHFACKDTFLFCTLCSIGTLAS--ISIIKE---Y---KL-----HAS-----------------------------------------------LDRKN---------------------------------------------------------------------------------------------- 'Candida tropicalis MYA-3404 catr 05923' --------------------------------------------------------------------------------------------------------------------------MKFDNSDKDIAVTFEEKSSFPNTPPESIHTLTKSDNQQPNN----------------------------------------------------------------------------------------------------GIDSKELCEKLGDAHSNILPTSQIIIILLTLSLATLVSFMDQTGITVGLSEIGKDLN------SQQT--INWAGSASLLANTVCQVLFGRMSDI-FGRKKVIMTCLMILIIGDVACSVAK-----TGIEFYIFRALAGIGNGGVSSLSMVILSDIVSLK--DRGKFQGILGSSVGIGN--AIGPFLMGAFIK--T--S---SWRS-YY---YFLAPLGFMVNVIFYFCL-------NNN----------SK--------------------------------------------------------------------------------------KLNQV-----VSRKE--------KF-----------KNI----DYFGILIASASLTLLLIPLNGGG-------STY----PWDS------KIVIIMFTLGGSL-M-ILFLVIEWK---------------------------FAK-L----------P-MIPLRLF-KSKSLCLLYFATFCFGAAY-FSFTYYMPYYFQIIKGKDEIQTAIFVLPLVLTQAG-GSIISGQIIT-R---------TGHY-FYVVTAGYIL-WLLSCCLL-----ILW--------------------------------N------ESLNDGICILILLIMGSGVGCSFQ-PSMVAVQANCL-KS------ERAVAISTRNVLRSLGGCVGIAVGSTI-V--SNTV-LKELNSINDD--------------------NTSLTDSIIT-YIQGHI------YEKINISNLDPIQVSEIRDI-YSRGLRNYFYFLIPLMGICVVT--ALFVKD---N---GL-----KAL-----------------------------------------------DEQEDQVPTQKVKDIESSATSITIR-------------------------------------------------------------------------- 'Kluyveromyces waltii NCYC2644 klwa 021-snap.20' ------------------------------------------------------------------------------------------------------------------------------------------------MSLKGHTEKKIDAHAQQIL----------------------------------------------------------------------------------------------------QRRKDAGVNNIEVYADQYSHIGYRILLFFSLFLVAYAYGLDGMVRYNFQAYATNSYG------SHSL--LSTVNCIKAVIAAAGQLCFARAADI-FGRISIIIVSILFYVVGTIIDSQAT-----TVSKYAAGACIYQLGYTGIILILEIIAMDFSNLN--WRLLASFVPAIPFIINT-WISGDVVSAVGAN----------WKW-GIGMWAFIFPLSALPLLGCMFHM-------RYL----------AR-------------------------------------RRASDRLVTEVSLYKHMS-------------------------------WSTYL--------TE-------VFF-----------WRL----DAVGLIMVCVVFGCILIPFTLAGS------LKD----KWQT------AEIIVPEVIGWCVAL-PLFLL--WE-M-------------------K-----FAK-H----------P-LVPWNVI-KDRGIWSALIIAIHINFIW-YMQGSFMYTVLIIAVNESVKSATRITSLYSFVSVL-TGLGLGFVIA-Y---------IRKT-KKFIMFGIGC-WVVSFGLL----IHYR----------------------------GD--S------SSH--SGIIGAQCLLGFGAGFFTY-TTQTSIQASAKTHQ------DMAVITALYLSFYNIGSALGSSVSGAI-W--TNIL-PRE----LRK--------------------RITDPTTYALAYGSPFT------FII--TYVWGTPEREAVVKS-YQYVQKLLCVVGICFCATLIAS--ALFLRD---H---RL-----GDS--------------------------------VALEDEDE-------KFSINSDAEGELQDSTESRNLKL---------------------------------------------------------------------------- Candida_guilliermondii_ATCC_6260_cagu_05184 ----------------------------------------------------------------------------------------------------------------------------------MSSRDSQEDQV--------KLPDNEENSVPVQK----------------------------------------------------------------------------------------------------HNFKSIGALKSELMISQYSEVVPKIAVLFSSFLIGFSYMLDGNVRSSFTGYATGSYG------HHSL--LSTINVVTTIIAAAGQVVYARLTDT-FGRAEMYVISIILYVVGTIIQSQAT-----NVARFATGAVFYQLGYVGVVLILLVMLSDFSSMR--SRLFFMLCPTFGYIIVT-WVSGNILNAVGPV--Q------HWSW-GIGMWAFIFPLANIPFLLCLGHM-------WYK----------AR-------------------------------------KLPEWKELKGTRSRIIREQG-----------------------------IGSFL--------VQ--------MF-----------WEL----DLVGALLLAVTLGCILVPLTLAGG------VKT----EWQK------AHIIVPIVIGGVL-I-PVFLA--WE-A-------------------Y-----VAR-Y----------P-LAPMVFF-SSRGIWCPLAISFTFMFVD-MLISEYLYTILIVAVNDTVTSGQRIITLSSFTSEI-VGFFYGLLII-Y---------VRRL-KPGLIFGTSM-WLVALGLM----YHFR----------------------------GG--T------SSK--PGIIGAEVVLGFGTAFFSY-PITVVMQSHLS-HD------YMAVVTGMGLTLYRIGGAVGSAVGGAI-W--SQLL-YKRLAKKLSP-------------------------EVASAAFSDPFT------WIL--TYTWDTPERQWAVQE-YRYVQRILITVGLVFTAPLILF--AVFTKE---R---RL-----SNE-----------------------------------------------ITVDQESNPDENDKDFDVIAFFKRKTK------------------------------------------------------------------------ Kluyveromyces_thermotolerans_CBS6340_klth0g13464g -----------------------------------------------------------------------------------------------------------------------MVQSEHSPLLTPVDRDAMQDPSTDLPGFVANQIEQQDHLLDIEQ------------GRAYGSTTKSSISSENE-----------------------------------------------------------------------REDAGGATVAGCGSAEFYLPSSRILIIMFSMFLGIFLAALDGTIVSTLLTHIGSEFN------SLDK--ASWIATSYLLSSSTCQPLYGKLSDR-LGRKPLLVFSNAVFAIGCLICGLSN-----SIWAVVAGRFISGIGGCGLTSLATMIMSDLVPLR--DRAVYQGLCNFVFGLGT--ASGGLVGAYFRD----------WRL-AF---ILQCPISVLSGILIVVYL-----ELPPR---------ASA--------------------------------------------------------------------------------------SNKDC--------WS-------ARL-----------RRL----DWAGATSLIAFLFLFMLTSSMGG-------SSV----AYGS------RLFAAMCAATLVF-G-AVFVY--VE-L-------------------R-----VAA-D----------P-VLPVTFL-RDRSVLGSSLANWFCMMSM-MTTNFYLPVYWSSVLGMKATDVGKRAMPSFFSVAF-GSLGAGLYMK-R---------TGKY-YYFLLAFCVL-AIAGQVQI-----VLI----------------------------TP--Q------MPV--WRQYLLQVVPGFGVSVLIT-VTLLAMIAAVP-HE------HHAATTSISYAFRSTGATLGVSVGAAV-F--RSSL-TSLLDAKVMR---------FASDG----HSERELRGIIAS-AARSSD------WVH---RSAPPFVRATLLEC-YHFASRATFKFCLTTMVLAGVS--CSIIKE---H---KL-----HTS-----------------------------------------------IKRGS---------------------------------------------------------------------------------------------- Debaryomyces_hansenii_CBS767_deha2e02948g ----------------------------------------------------------------------------------------------------------------MQEHVNFDGANKNLENLENQLSASLNTANISQVEGNTKSRVVRETDVQNNI----------------------------------------------------------------------------------------------------GDDELDLAERLGDAHLNILPTKKMIVCLATMSLGLFISFVDQTGITIALPHIAKDLN------AETT--INWAGTSSLLANCVCQVLVGRFADI-FGRKTVLLYSFFLLAVADLACGLAK-----TGVQFFIFRACCGIANGGIQLLTNIIISDIVVLK--KRAKYYGILSSSIGLAN--CTGPLILAGFIK--G--S---SWRT-FY---YIMPAICFLVAVIIYFVV-------NKN----------RK--------------------------------------------------------------------------------------DKQEV-----LSRRE--------KF-----------KKI----DYLGFIFSSAGLILLLIPISGGG-------STY----KWNS------GLIIAMFIVGGLC-L-VGFLLIEWK---------------------------IPR-L----------P-MIPLGLF-KSGLLSLVLSTNFLYGMTY-YSFTYYIPYYFQIVRGYDSIMASVLLIPLVLMQAI-NSIISGQIIS-Y---------TGHY-KHVILFGYGS-WVLSCGLL-----LLW--------------------------------S------ETINIGVVIVVLLIMGIGLGFTFQ-PCMVAAQAQAR-KS------ERAVVIGARNVIRSFGGAIGIAMGSLI-V--SNTL-LKEINQALVH-----------------KEKYANIPTDYLN-YLKLHI------YTRIEVTGLNEKQVKVIKSM-YMKSLMNYFYLGIPLIGICFIS--SFFLKD---RGVQCI-----DEQ-----------------------------------------------PEPKDKEKDITSK-------------------------------------------------------------------------------------- Candida_lusitaniae_ATCC_42720_calu_00809 --------------------------------------------------------------------------------------------------------------------MSITPKSSNAHNNTPLSPNIIKDSSTGGAGVIAGELAAEDVGLISKD------------TLASHQYGSLSEENTGYR----------------------------------------------------------------------APEEREGEGETDDLNGFALPKRQLYTVIGSLYMASFLAALDTTVVTTLLSVIASDLN------AVEN--IAWIATAYLLSCSAFQPLFGKLSDI-FGRKVLLVICCAFFGVGCCICVTD------SLFWLVFGRFITGCGGSGLTTLGTITMSDLIPLR--ERGLYQGLANICFGLGA--ASGGIIGGAVAD--Y--F---GWKY-VF---VLQVPLAAIVGVAIYSYL-------NLP----------AG-----------------------------------------SPGLGS---------------------------------------PGTEF--------KE--------KL-----------KRV----DFLGAFLLVSALMSILTAASMGG-------KQL----AYSS------PFFITLIIVSAAL-L-VAFVY--VE-T-------------------Y-----VSS-E----------P-IIPMEVM-TERTVLASSLSNWFYTMGV-FAYLFYVPLFFQAGMGFSATQGGERLIPNFFAVSC-GSVGAGLYMR-K---------TGRY-YKLTVAVGLL-SLLGMIRI-----ILL----------------------------SP--K------SSL--FTQFTILLIPGLGYSCMLT-VTLLSLIAAVP-VK------YQACTTSIQYTFRATGSTLGVAIASAV-F--QNVT-RSQ----MVS-----RIHALV-------SDEKLANDIISR-ALENTS------YAK----EAPKIVQHAIMKS-YQLGCRGTFIFSTVTIALGYFS--SLFMRE---H---VL-----HTK-----------------------------------------------IERD----------------------------------------------------------------------------------------------- Kluyveromyces_polysporus_DSM_70294_klpo_416.6 ---------------------------------------------------------------------------------------------------------------------------MITDKDENIKQNETIHSEEFSSNITVSSITTNSLNGEKEP----------------------------------------------------------------------------------------------------HLEESAGVYNSEVYAKYYSSPTRRSIVFLCLFFICYAYGLDNKLRSPYQTLATSSYK------QHSL--LSTVNAIKSVISAAGQIWFARASDL-FGRGTILIVAVMFYVVGTIVESQAV-----DVSKFAAGACLFQLGYDGVVMMVQILVSDFSNLN--WRVTAVAFPVLPNVINT-WVSGDIASAVDEN----------WKW-GIGMWAFIFPLSCIPFGILLLHM-------KYL----------AR-------------------------------------KNNDTLKSSFDKPEDIT--------------------------------WKQYL--------TE-------IFL-----------WKL----DFIGLLLAVAFFGLVLVPFTLAGG------LNK----KWKT------ARIIVPEVLGWVVAF-PAFLT--WE-I-------------------K-----FAK-Y----------P-LTPWKTV-KDRGVFSALIIAIFLQTAF-YMQKTYMYTILLVAVNQTKKSATRINSLFTFVTAL-SGTLLGLVIV-K---------VRRT-KEFIFFGIAV-WFLSFGLL----ERYT----------------------------GG--T------NAY--AGIIAALCLLGFGNGFIKY-PTKASMQASALTHE------MMAIITSLFMAISTIGTSVGSSVAGAI-W--TNVL-PDKIEKGLNN------------------------STLANFAYNSPTK------FIL--QYNWESPERQIVVNA-YKHVEKILIIVGLCFLVPLLGG--AFLLRN---Q---RL-----EDA-----------------------------------------------VALDKVEPKNEKKEMEV---------------------------------------------------------------------------------- Candida_parapsilosis_CDC_317_capa_02998 ---------------------------------------------------------------------------------------------------------------MSQDRTNSTSSTETSYSHDKHIKFDETQGIKYSEKTVPTTPSESIHTVVGNQ----------------------------------------------------------------------------------------------------AVEANALADKLGDAHFNQLPTSQIITILLTLSLANFVSFADQTGITVGLSEIGKDLN------AQQS--INWAGSASLLANTVCQVLFGRLSDI-FGRKNVIMTCLMILCIGDIACSVAR-----NGVEFFVFRALAGIGNGGVSSLCMVILSDIVSLK--DRGKYQGILGSSVGIGN--AVGPFIMAGFIK--Q--S---SWRS-YY---YFLAPLAFCVNIVLFFSL-------KNN----------KK--------------------------------------------------------------------------------------LNDVI------SRKE--------KF-----------KSI----DYLGIISATIGLTLILVPLNGGG-------VTY----AWDS------TLVIVMFTIGGVF-M-ILFLG--IE-G-------------------K-----VAK-L----------P-MIPLRLF-KNLSLCLIYLATFCFGATY-YSFTYYLPYYFQIVKGKDEIQTSVFVLPLVLCQAA-FSVVAGQLIT-F---------TGHY-FYVVVAGYIL-WCLACCLL-----VLW--------------------------------N------ASLPDGINILILLIMGTGVGFSFQ-PSMVAAQANCK-KA------ERAVAISTRNVLRSLGGCVGIAVGSTI-V--SNSV-LSS----LNN---------LGSST--------SLTQSTID-YVKGHI------YNKVNVDSLTAAETKEIRDI-YTNALRNYFYLLIPLMAICVIT--TCFVKD---NGLCSL-----DER----------------------------------------------PPLKKKEDLESSASSMTLRN-------------------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0a00726g -----------------------------------------------------------------------------------------------------------------------------------------MSAL--------EDNSSKELCTQAES----------------------------------------------------------------------------------------------------STSEVVEQNKKVVSQDQVVKGFALYACLGSLTLALFLSALDILIVSTIIETVSRDFN------EYSK--SGWLVTGYSLPTALLSLVWGRAASI-IGFKSSMLLSIIIFEVGSLVSALAN-----SMNMLIGGRVISGVGGSGLQTLCFLIISTLVNER--SRGMAISVLSCSFAVAS--IVGPFLGGAFTT--H--V---TWRW-CF---YINLPIGGLAFLVFVLSY-------NPN-------------------------------------------------GGNSIKNFTKAVRSISHVDFGGLLKAKS---------------------YYNTF--------EK--------LV-----------FKF----DFVGFALCSAGFCLILLGLTFGG-------NEY----SWGS------GTIIAYLVIGIVL-S-IAFFL--YD-FFVFNRFKAPRE--------N-----MVY-R----------P-LVSWNVI-SKPGVITATAVNFTICLMY-NAQVIYIVQFFQLIHGSTAWKAGIHLIACVVPTII-TVNISGIING-K---------TGHV-KFIIVVGVVA-AIVGAGLL-----TLL----------------------------DN--N------SGS--SKHIGLLILPGIAFGAIIQ-STLMSSQIQID-KSSPSFRHDFISVTTINSFAKALGTAFGGVISNTV-F--TTSV-HNK----LVE-----SHLNLPTGS--------SASQLIIY-RAQNFD-------------GPKSAVGYILSDS-----IKNVFWMALGFSAVALIF--GLLCSN---K---KI-------------------------------------------------------DIRKPGTDQAETEVTKDEEAEQTPKI------------------------------------------------------------------------- 'Candida tropicalis MYA-3404 catr 01806' ------------------------------------------------------------------------------------------------------------------------------------MSTYPTMTDEAKESSEKSYYRSNPTDTESVE----------------------------------------------------------------------------------------------------EEKSIGVHKAEILANQWKHTFWYKVILGFSAFLCGYAYGLDSQIRYIFTAYATSAFS------EHSL--LTTVNAIIGVVAAASQPVYARLSDV-FGRLELFIVAVLFYVVGTIIEGQSP-----NINTYVAGAVLFQVGYSGIIIMVVFIMSDFSSLR--WRLFFTLCPAFPFIINT-WISGNVTAAVGTN----------WKW-GISMWSFIFPLACIPLVCCLLHM-------RYL----------AG-------------------------------------KTEEWKVFKQRKTKFQELG------------------------------PVGFA--------KF--------LF-----------WRL----DVIGLILLVAALGCLLVPITLAGG------ISS----SWKK------AHIIVPVVIGGAL-F-PVFGL--WE-V-------------------Y-----GAK-E----------P-IIPLYLM-KDRGIWAPAVISFLFDFVY-AVESNFLYTVLMVAVNESQASATRISSISSFVSVI-VGFFFGLFVV-Y---------FRRL-KGFAIFGCVL-WLVGFGIL----YHFR--------------------------------S------QLHAHSGIIGGMVVIGFGTGLLTY-PINVLAQSCVK-HE------YLAIVTSAMYTLYRVGWSVGSAVASAV-W--SSKL-YKRLVHYLGD------------------------ETLAASIYGDPYT------FIA--EYAWGSPEREAAVLA-YADVQRILMTVCMCFVAPMIIV--GFFMRD---P---KL-----TNE-----------------------------------------------QSLDEKERQEQKDSISGFFQGLRKNKSEV---------------------------------------------------------------------- Pichia_stipitis_CBS_6054_pist_igi16601804 -----------------------------------------------------------------------------------------------------------------MTNTIAGKSSLGSQAYETDSSSITPVIVSIVDSSEVSVNTDDGKEGKIQE----------------------------------------------------------------------------------------------------PILNVEDSTSGETSNEQYLHGTRLWACMVSVLSCLFLLGLDQTIVITIISEVGNKFN------AIEK--VGWLSSGFLLAVCIFAPFWGNFSIS-FGRKTTMIISVVIFEIGCLICALAN-----SMELLIAGRFIAGIGGGGIQSTSYIICAEIVPIE--QIPLSMSCIAMVYALST--IAGPLVGGAFTT--H--V---TWRW-SF---YINLPVGAIALLLLIFSW-------HPP-----------K--------------------------------------------------------------------------------------SHGTL--------KE--------KL-----------KKI----DYLGTILIIVGLVLILLALTFGAS------YEF----PWRS------GLIISFFIVGALF-L-VAFCI--WN-F-------------------K-----YSH-N----------P-LIPLSVV-KVPQINAAAVGMGFMFAYF-TATTLYLSIYFQIVRNRTAFQTGIALFPIIIGVVL-SSGVSGYLSK-L---------TGHV-KLWVVFAGIL-GPIGVGLL-----TLY----------------------------DV--H------NPN--SQDIGLQIVLGVALGIQFQ-ALLISAQIKAP-TVPG----GKIMTISYIVFARCLGGAISANLADLA-Y--ASTF-VNKFRSLLSK--------------------STDPTILSELGSMSPYE----LLHSSTRINSLSIVSQQFVKNQ-YVAAINNVYYMCIAFACVSLVG--CILTTN-------KM-----LPQ-----------------------------------------------EEISNNDATVVNRSEKEDVDNAV---------------------------------------------------------------------------- Candida_dubliniensis_CD36_cadu_22250 --------------------------------------------------------------------------------------------------------------------------------MTSYQSNNHFSEEDKRFSGDEKTFSPSDIVEKAIV----------------------------------------------------------------------------------------------------EEKSIGVEKAEILANQWKHTFWFKLLLGFSAFLCGYAYGLDSQTRYVYTAYATASWS------EHSL--LTTVNAITGVVAAASQPVYARLSDV-LGRLELFIVAVLFYVVGTIIECQSP-----TINAYVAGAVLYQIGYSGIIIMLLFILSDFSSLR--WRLFFTLCPSFPFIINT-WISGNVTAAIGTR----------WKW-GIGMWAFILPLSCIPLVCCMLHM-------RWL----------AG-------------------------------------KTEEWRVFKQRKTKFQELG------------------------------VLGFT--------KY--------LF-----------WRL----DVIGLLVLTVSLGCLLVPLTLAGG------IKE----TWQK------AHIIVPIVIGGVL-I-PVFLL--WE-G-------------------Y-----GAR-D----------P-IVPLHLM-KDRGIWSVVTISFFLDFVF-AVESNFLYTVLMVAVNESQSSATRIASLSSFVSVV-TGFIFGLFVV-Y---------FRRV-KGFVVFGCAM-WMVAFGIM----YHFR--------------------------------S------QLHAHAGIIGGMCLMGFGTGFFSY-PINVSAQSCVT-HE------HMAVISSALFTTYRIGYAVGSSVAGAI-W--SQML-YSRLVKYLSD------------------------ATLATSVYTDPYT------FIA--TYVWGSPEREAAVKA-YGEVQRVLMSVCIAFVAPMIVS--ALFMRD---H---KL-----TNE-----------------------------------------------QSLEDVEKQEKKDSLSNFFSRFKKRQADV---------------------------------------------------------------------- Candida_guilliermondii_ATCC_6260_cagu_00173 ---------------------------------------------------------------------------------------------------------------------MSTFNQALKEPSISEQIKPTEISSLAGSQNEEKTQVAVKTSAQNED------------SLEFERGESSDQ----------------------------------------------------------------------------PQDAILLGAAKVEATLLVWSKTAVYFTFLWIWVCFFLLNLQSSIASNIMYYAYADFA------AAPQ--INTAFILSSIIGGVLQLPIGRALTI-WGRAEGFLVVLSVYVLGLIVSAACT-----GPDSFAAGYVLHSVGYQSLGFILSVFVADASGLR--NRGLAYAFVGTPTLCTA--FTGPLAAQSFIK--M-----SSWRW-AYGTFAIVQTVTFIPLAVLFKHF-------EKK----------AK-------------------------------------KEGILNEVDKGRT------------------------------------TLQSI--------VH--------YF-----------HDF----DIVGAFVLSSAFILLLLPFSLKTY------GRT----EYKS------VTFIIMVVLGGLL-I-PVFGI--WE-K-------------------Y-----FAR-T----------H-FIKWQLF-RDRTVLGSCVLAACIFFNF-YCWDAQYYNFVIVVYNLSVSMAGYMAQIYTVGSVI-WSVLFGLYIR-Q---------VNRFKKACLYFGLPL-MMLGAGLM----VRFR----------------------------GQ--E------SNI--GYIIMCQIFLAFSGGTLII-GNEVAGLCAAD-IG------EIPMILSLLGLWSNLGGAIGSAVAAAI-Y--TNTF-PSTLYKNLPE------------------SAKPNATEIYLGGYTTQML------------YPVGSDERKAINQA-WGQTQKNSCIAALCVMVLAFPA--IASWKN---Y---NV-----KST-----------------------------------------------HHKGIVL-------------------------------------------------------------------------------------------- Candida_lusitaniae_ATCC_42720_calu_04864 -----------------------------------------------------------------------------------------------------------------------------MQRQKKRNFNVINQNITHKDLISGEDKMADPTEEKTTK----------------------------------------------------------------------------------------------------AYFESDAGDGTKREDMYLEGKE-LILCFIAIFCSFFLFALDQTIIATLLTTVGNKFH------SFDK--IGWLSAGFLISMAVLSAIWGKLSII-FGRKITMMVAIVLFEAGSLMCALAN-----NMNVLIGGRVLAGVGGGGIQSVAFIIITEILPIH--KRPMGMAIISMVFAVAS--VLGPLIGGAFTS--H--V---TWRW-CF---YINLPVGGAAFLLFVFVY-------NPP-----------K--------------------------------------------------------------------------------------SKGSI--------RE--------KL-----------KLI----DYPGVLLLSSGLVVLLLAITFGAG------GQY----AWNS------AAVIVCFVVGGVV-T-IVFFI--WN-V-------------------R-----FSK-N----------P-MLPWEVL-RVFQIEASAFALFGSFASF-MSSALYLSVYFQVIHDADAWKSGLHLLPLIVAVVL-FSFSSAMLCK-----------ITRYVKPFAVFGAVW-CMVGAGLL-----CLL----------------------------DV--D------SSK--SKKIGLLIPMGVGIGSLMQ-AGILSAQIMAP-KTPG----GTIMATVLANFLRSFGGALSSNLADAV-Y--AATY-LNKVNENLKY---------------QPEEVIKELSTIDVRAIVNSTA----------ALAKLSAPARKFLKAQ-LMSGIKNTFYMNLGFCAITVVS--ACFITN---K---RL-----PKA------------------------------VPQERDEKKTESEAAESDSVEAAENDSVEANTKDESSATE---------------------------------------------------------------------------- 'Kluyveromyces waltii NCYC2644 klwa 018-snap.54' ---------------------------------------------------------------------------------------------------------------------------------------------MIFKSKSDAIISDTFVDTQEFL----------------------------------------------------------------------------------------------------HRRKDAGVKNIKVYADQYNNVFYRVALFFSLFLVAYSYRLDGLVRGKLETYATDSYG------HHSL--LSTVNCIKTVIGAAGLIAYARASDI-FGRMTMLAIAVLLYVVGTIVECQSN-----TVSKFATGASIFQLGKAGIVLLLQVIAMDFSTLN--WRMVALYVPALPIIINT-WVSGDIIKAINGN----------WKW-GIGMWAFILPLACLPLFGCLIHM-------RYL-----------------------------------------AHKNCKDQLVNEWELYKNTS-------------------------------------WPAYL--------KE-------VFF-----------WRL----DILGLILITAGLGCVLIPFTLAGG------LSD----KWKS------AHIIVPEVIGWCVAF-PLFVL--WE-K-------------------K-----YAR-H----------P-LTPWRLL-KDRGVISAIIIGFHIHFVV-YMQADYMYTVLVVAVNESVKSAQRITTLFNFVTII-TGTLLGFVIA-Y---------VKRT-KKFILFGICI-WFVAFGLL----IRYR----------------------------GD--S------SSH--SGIVGALCLLGFGGGFFNY-ATQVSLHASTSSHQ------DMAVITSLYLASYNVGSAVASAVAGAI-W--TNVL-PKQLHKRISD------------------------ASIANIAYSSPFK------FIK--KYKWGSPERIAVMQA-YQVVQKILCTVGLCFCVTLLVA--ALFLRD---K---KL-----ESV----------------------------------VALEDAEEKEPSINSQHSSTNGPEWGLQEEKTKTDSEKSN------------------------------------------------------------------------ Candida_albicans_SC5314_caal_a_19.2179 -------------------------------------------------------------------------------------------------------------------------------MTSYQSSNNHSSEEDKHLSGDEKTFSPSDIVEKAIV----------------------------------------------------------------------------------------------------EEKSIGVEKAEILANQWKHTFWFKLLLGFSAFLCGYAYGLDSQTRYVYTAYATASWS------EHSL--LTTVNAITGVVAAASQPVYARLSDV-LGRLELFIVAVLFYVVGTIIECQSP-----TINAYVAGAVLFQIGYSGIIIMLLFILSDFSSLR--WRLFFTLCPSFPFIINT-WISGNVTAAVGTR----------WKW-GIGMWAFILPLSCIPLVCCMIHM-------RWL----------AG-------------------------------------KTEEWRVFKQRKTKFQELG------------------------------VAGFS--------KY--------LF-----------WRL----DVIGLLLLTVSLGCLLVPLTLAGG------IKE----TWKK------AHIIVPIVIGGVL-I-PVFLL--WE-G-------------------Y-----GAR-D----------P-IIPLHLM-KDRGIWSVVSISLFFDFVF-AVESNFLYTVLMVAVNESQSSATRIASLSSFVSVV-TGFIFGLFVV-Y---------FRRL-KGFVVFGCAM-WMVAFGIM----YHFR--------------------------------S------QLHAHAGIIGGMCLMGFGTGFFSY-PINVSAQSCVS-HE------HMAVISSALYTTYRIGYAVGSSVAGAI-W--SQML-YSRLVKYLGD------------------------STLATSVYTDPYT------FIA--QYVWGTPEREAAVKA-YGEVQRVLMSVCIAFVAPMIVS--ALFMRD---H---KL-----TNE-----------------------------------------------QSLEDVEKQEEKDSLANFFGNFKKKRVAV---------------------------------------------------------------------- Candida_albicans_SC5314_caal_a_19.7336 -------------------------------------------------------------------------------------------------------------------MSLDYTKDRKTTITFDEKQLPGTPPESITTLTDLNNNNNNNNDKSKDH----------------------------------------------------------------------------------------------------EIKPQELADKLSDAHSNLLPKSQIIIILSTLALASIVSFMDQTGITVGLSEIGKDLN------AQQS--INWAGSASLLANTVCQVLFGRMSDI-FGRKNVIMTCLMILVIGDIACSVAR-----NGIEFFVFRALAGIGNGGVSSLSMVILSDIVSLK--DRGKYQGILGASVGIGN--AIGPFIMGAFIK--K--S---SWRS-YY---YFLAPLGFVVNVILYFCL-------KNN----------KK--------------------------------------------------------------------------------------LNDVI------SRKE--------KF-----------MSL----DYTGILAATASLTLILIPLNGGG-------STY----SWDS------NIVIIMFTVGGVL-L-IVFLGIEWK---------------------------FAK-L----------P-MIPLRLF-KSPSLCLLYLATFCFGATY-FSFTYYMPYHFQMIKGKDEIGTAIFLLPLVLMQAL-SSIICGRIIS-F---------TGHY-FYVVQAGYLL-WLLSVCLL-----ILW----------------------------KK--T------LPD--GIHILILFIMGTGVGAAFQ-PSMVAVQANCK-KA------ERAVAISTRNVLRSLGGTVGIAIGSTI-V--SNSV-LKE----LKP---------LN-------SSNSNLSPETIN-YIKGHI------YEKIPLTNLNNQQINEIKDI-YTAALRNYYYFLIPLMAICVIT--AMFVKDNGLK---AL-----DEQ--------------------------------TPIDTKDF-------IERKKDLESSASSMTVKCENV------------------------------------------------------------------------------ 'Candida albicans WO-1 caal b 02209' -------------------------------------------------------------------------------------------------------------------MSLDYTKDRKTTITFDEKQLPGTPPESITTLTDLNNNNNNNNDKSKDH----------------------------------------------------------------------------------------------------EIKPQELADKLSDAHSNLLPKSQIIIILSTLALASIVSFMDQTGITVGLSEIGKDLN------AQQS--INWAGSASLLANTVCQVLFGRMSDI-FGRKNVIMTCLMILVIGDIACSVAR-----NGIEFFVFRALAGIGNGGVSSLSMVILSDIVSLK--DRGKYQGILGASVGIGN--AIGPFIMGAFIK--K--S---SWRS-YY---YFLAPLGFVVNVILYFCL-------KNN----------KK--------------------------------------------------------------------------------------LNDVI------SRKE--------KF-----------MSL----DYTGILAATASLTLILIPLNGGG-------STY----SWDS------NIVIIMFTVGGVL-L-IVFLGIEWK---------------------------FAK-L----------P-MIPLRLF-KSPSLCLLYLATFCFGATY-FSFTYYMPYHFQMIKGKDEIGTAIFLLPLVLMQAL-SSIICGRIIS-F---------TGHY-FYVVQAGYLL-WLLSVCLL-----ILW--------------------------------K------KTLPDGIHILILFIMGTGVGAAFQ-PSMVAVQANCK-KA------ERAVAISTRNVLRSLGGTVGIAIGSTI-V--SNSV-LKELKPLNSS--------------------NSNLSPETIN-YIKGHI------YEKIPLTNLNNQQINEIKDI-YTAALRNYYYFLIPLMAICVIT--AMFVKD---NGLKAL-----DEQ-----------------------------------------------TPIDTKDFIERKKDLESSASSMTVKCENV---------------------------------------------------------------------- 'Candida albicans WO-1 caal b 05897' -------------------------------------------------------------------------------------------------------------------------------MTSYQSSNNHSSEEDKHLSGDEKTFSPSDIVEKAIV----------------------------------------------------------------------------------------------------EEKSIGVEKAEILANQWKHTFWFKLLLGFSAFLCGYAYGLDSQTRYVYTAYATASWS------EHSL--LTTVNAITGVVAAASQPVYARLSDV-LGRLELFIVAVLFYVVGTIIECQSP-----TINAYVAGAVLFQIGYSGIIIMLLFILSDFSSLR--WRLFFTLCPSFPFIINT-WISGNVTAAVGTR----------WKW-GIGMWAFILPLSCIPLVCCMIHM-------RWL----------AG-------------------------------------KTEEWRVFKQRKTKFQELG------------------------------VAGFS--------KY--------LF-----------WRL----DVIGLLLLTVSLGCLLVPLTLAGG------IKE----TWKK------AHIIVPIVIGGVL-I-PVFLL--WE-G-------------------Y-----GAR-D----------P-IIPLHLM-KDRGIWSVVSISLFFDFVF-AVESNFLYTVLMVAVNESQSSATRIASLSSFVSVV-TGFIFGLFVV-Y---------FRRL-KGFVVFGCAM-WMVAFGIM----YHFR--------------------------------S------QLHAHAGIIGGMCLMGFGTGFFSY-PINVSAQSCVS-HE------HMAVISSALYTTYRIGYAVGSSVAGAI-W--SQML-YSRLVKYLGD------------------------STLATSVYTDPYT------FIA--QYVWGTPEREAAVKA-YGEVQRVLMSVCIAFVAPMIVS--ALFMRD---H---KL-----TNE-----------------------------------------------QSLEDVEKQEEKDSLANFFGNFKKKRVAV---------------------------------------------------------------------- Candida_parapsilosis_CDC_317_capa_02455 -----------------------------------------------------------------------------------------------------------------------------MPSSIHSDLKATSMDEEKQTYDKTFSDNTSTELEHAIE----------------------------------------------------------------------------------------------------EEKSIGVLKAELLAEQWKHTFWYKLVLLISAFLVGYAYGLDSQIRYVFTGYATASWS------EHSL--LTTVNAITALAGAAAQPVYARLSDV-FGRLELFIVSVLFYVVGTIIECQSP-----TINAYVAGAVLYQIGYSGVLIVLIFILSDFSSLR--WRLFYAICPSLPFIINT-WISGNVTSAVGMN----------WKW-GIGMWAFIFPLACIPFVCCMIHM-------RWL----------AG-------------------------------------RTPEWVEFKKKETLYQKFG------------------------------FWGFM--------KY--------LF-----------WKL----DCIGLLLMVVSLGCLLVPLTLAGG------VSE----KWKQ------GNIIAPIVVGCVL-I-PVFCI--WE-C-------------------------FAK-D----------P-IIPFTLM-KDRGIWSAGLISFLFDFVF-AVEANLLYTVLVVAVNESQKSATRITSLGSFASTV-CGGLFGLVIV-Y---------IRRL-KGFVIFGCSL-WMVAMGLM----YHYR----------------------------ST--L------SAH--GGIIGGQVVMGIGTGFFSS-SLAVTAQSCVN-HE------HMAVITSGIYTLYRIGSAVGASVAGAI-W--SQTL-LKR----LEK--------------------YLDSTTAVSV-YGSPYV------FAQ--NYAWGTPEREGATKA-YGEVQRLLIIVAICFVAPMIIS--ALFLRD---R---KL-----TRE-----------------------------------------------QTIENVEEENANDSLGKFIKGFGLRRSEKA--------------------------------------------------------------------- Saccharomyces_mikatae_IFO_1815_sami_a_c633_10615 -----------------------------------------------------------------------------------------------------------------------------METDASRNDNLDDKSTVCYSEKVGTDINRSTKSGLHRI----------------------------------------------------------------------------------------------------DAVNKVLSDYGSFTAFGITFNSLKITLLVALFLQGYCTGLGGQISQSIQTYAANSFG------KHSQ--VGSINTVKSIVASVVAVPYARMSDR-FGRIECWMFALVLYTVGEIISAATP-----TFAGLFAGIVIQQFGYSGFRLLATALTGDLSGLR--DRTFAMNIFLIPVIINT-WVSGNIVSSVAGH-----TTPYNWRW-GYGIFCIIVPFSTLMLVLPHAYA-------QYI----------------------------------------------------GWRNGTLPPYKLRE--------------------------------KGQNL--------RQ--------ML-----------WKIVEDINLIGVILFSAFLVLLLLPLTIAGG------ATS----KWRE------GYIIAMIVVGGCL-G-FIFLI--WE-L-------------------R-----FAK-N----------P-FIPRVYL-GDPTIYVALLMEFVWRLSL-QIELEYLVTVLMVAFGESKLSAQRIAQLYNFLQSC-TNIVVGIILH-F---------YPHP-KLFVVAGSLL-GVLGMGLL----YKYR----------------------------VV--Y------DGI--SGLIGAEIVVGIAGGMIRF-PMWTLVHASTT-HN------EMATVTGLLMSVYQIGDAVGASIAGAI-W--TQCL-AKELIQRLGS-------------------------NLGMSIYKSPLN------YLK--KYPIGSEVRDQMVES-YSKIQRLLIIVSISFAAFNAVL--CFFLRGFTVNKKQSF-----STE-----------------------------------------------EREKEKLRITQQSWLRRVVGY------------------------------------------------------------------------------ 'Saccharomyces bayanus 623-6C saba a 479.6' ----------------------------------------------------------------------------------------------------------------------------MMETDPSKNDNLDDKSTAGYSEKAETEDDKSTGSGIRRI----------------------------------------------------------------------------------------------------DAVNRVLSDYGSFTAFGVTFSTLKTVLLVALFLQGYCTGLGGQISQSIQTYAANGFG------KHSQ--VGSINTVKSIVASVVAVPYARMSDR-FGRIECWIFALVLYTVGEIISAATP-----NFGGLFAGIVIQQFGYSGFRLLATALTGDLSGLR--DRTFAMNIFLIPVIINT-WVSGNIVSSLAGS-----VAPYKWRW-GYGIFCIIVPFSTLILVLPYAYA-------QYI----------------------------------------------------SWRNGTLPPFKLKE--------------------------------KGQNL--------RQ--------TI-----------WKFAEDINLIGIILFTAFLVLVLLPLTIAGG------ATS----KWRE------GYIIAMIVVGGFL-G-FIFLI--WE-L-------------------R-----FAK-N----------P-FIPRVYL-GDPTIYVALLMEFVWRLGL-QIELEYLVTVLMVAFGESTLSAQRIGQLYNFLQSC-TNIVVGIILH-F---------YPHP-KVFVVAGSLL-GVLGMGLL----YKYR----------------------------VV--Y------DGI--SGLIGAEIVVGIAGGMIRF-PMWTLVHASTT-HK------EMATVTGLLMSVYQIGDAVGASIAGAI-W--TQRL-AKELIQRLGY-------------------------DLGMSIYKSPLN------YLK--KYPIGSEVRVQMLDS-YSKIQRYLIIVSISFAAFNAVL--CFFLRGFTVNNKQSF-----STE-----------------------------------------------EREQEKLKIKQQSWLRRVIGY------------------------------------------------------------------------------ 'Saccharomyces bayanus 623-6C saba a 673.6' ----------------------------------------------------------------------------------------------------------------------------MIETYPSKNDNLDDKSTAGYSEKAETEDDKSTGSGIRRI----------------------------------------------------------------------------------------------------DAVNRVLSDYGSFTAFGVTFSTLKTVLLVALFLQGYCTGLGGQISQSIQTYAANGFG------KHSQ--VGSINTVKSIVSSVVAVPYARMSDR-FGRIECWIFALVLYTVGEIISAATP-----NFGGLFAGIVIQQFGYSGFRLLATALTGDLSGLR--DRTFAMNIFLIPVIINT-WVSGNIVSSLAGS-----VAPYKWRW-GYGIFCIIVPFSTLILVLPYAYA-------QYI----------------------------------------------------SWRNGTLPPFKLKE--------------------------------KGQNL--------RQ--------TI-----------WKFAEDINLIGIILFTAFLVLVLLPLTIAGG------ATS----KWRE------GYIIAMIVVGGFL-G-FIFLI--WE-L-------------------R-----FAK-N----------P-FIPRVYL-GDPTIYVALLMEFVWRLGL-QIELEYLVTVLMVAFGESTLSAQRIGQLYNFLQSC-TNIVVGIILH-F---------YPHP-KVFVVAGSLL-GVLGMGLL----YKYR----------------------------VV--Y------DGI--SGLIGAEIVVGIAGGMIRF-PMWTLVHASTT-HK------EMATVTGLLMSVYQIGDAVGASIAGAI-W--TQRL-AKELIQRLGY-------------------------DLGMSIYKSPLN------YLK--KYPIGSEVRTQMLDS-YSKIQRYLIIVSISFAAFNAVL--CFFLRGFTVNNKQSF-----STE-----------------------------------------------EREQEKLKIKQQSWLRRVIGY------------------------------------------------------------------------------ Saccharomyces_cerevisiae_S288C_sace0o00308g ----------------------------------------------------------------------------------------------------------------------------MLETDHSRNDNLDDKSTVCYSEKTDSNVEKSTTSGLRRI----------------------------------------------------------------------------------------------------DAVNKVLSDYSSFTAFGVTFSSLKTALLVALFLQGYCTGLGGQISQSIQTYAANSFG------KHSQ--VGSINTVKSIVASVVAVPYARISDR-FGRIECWIFALVLYTIGEIISAATP-----TFSGLFAGIVIQQFGYSGFRLLATALTGDLSGLR--DRTFAMNIFLIPVIINT-WVSGNIVSSVAGN-----VAPYKWRW-GYGIFCIIVPISTLILVLPYVYA-------QYI----------------------------------------------------SWRSGKLPPLKLKE--------------------------------KGQTL--------RQ--------TL-----------WKFADDINLIGVILFTAFLVLVLLPLTIAGG------ATS----KWRE------GHIIAMIVVGGCL-G-FIFLI--WE-L-------------------K-----FAK-N----------P-FIPRVYL-GDPTIYVALLMEFVWRLGL-QIELEYLVTVLMVAFGESTLSAQRIAQLYNFLQSC-TNIVVGIMLH-F---------YPHP-KVFVVAGSLL-GVIGMGLL----YKYR----------------------------VV--Y------DGI--SGLIGAEIVVGIAGGMIRF-PMWTLVHASTT-HN------EMATVTGLLMSVYQIGDAVGASIAGAI-W--TQRL-AKELIQRLGS-------------------------SLGMAIYKSPLN------YLK--KYPIGSEVRVQMIES-YSKIQRLLIIVSISFAAFNAVL--CFFLRGFTVNKKQSL-----SAE-----------------------------------------------EREKEKLKIKQQSWLRRVIGY------------------------------------------------------------------------------ Saccharomyces_cerevisiae_EC1118_sace_b_1o4_0034g ----------------------------------------------------------------------------------------------------------------------------MLETDHSRDDNLDDKSTVCYNEKTDSNVEKSTTSGLRRI----------------------------------------------------------------------------------------------------DAVNKVLSDYSSFTAFGVTFSSLKTTLLVALFLQGYCTGLGGQISQSIQTYAANSFG------KHSQ--VGSINTVKSIVASVVAVPYARMSDR-FGRIECWIFALVLYTVGEIISAATP-----TFGGLFAGIVIQQFGYSGFRLLATALTGDLSGLR--DRTFAMNIFLIPVIINT-WVSGNIVSSVAGN-----VAPYKWRW-GYGIFCIIVPISTLILVLPYVYA-------QYI----------------------------------------------------SWRNGKLPPLKLKE--------------------------------KGQTL--------RQ--------TL-----------WKFAEDINLIGVILFTAFLVLVLLPLTIAGG------ATS----KWRE------GHIIAMIVVGGCL-G-FIFLI--WE-L-------------------R-----FAK-N----------P-FIPRVYL-GDPTIYVALLMEFVWRLGL-QIELEYLVTVLMVAFGESTLSAQRIAQLYNFLQSC-TNIVVGIMLH-F---------YPHP-KVFVVAGSLL-GVLGMGLL----YKYR----------------------------VV--Y------DGI--SGLIGAEIVVGIAGGMIRF-PMWTLVHASTT-HN------EMATVTGLLMSVYQIGDAVGASIAGAI-W--TQRL-AKELIQRLGS-------------------------SLGMAIYKSPLN------YLK--KYPIGSEVRVQMIES-YSKIQRLLIIVSISFAAFNAVL--CFFLRGFTVNKKQSL-----SAE-----------------------------------------------EREKEKLKIKQQSWLRRVIGY------------------------------------------------------------------------------ 'Saccharomyces cerevisiae RM11-1A sace d 01250' ----------------------------------------------------------------------------------------------------------------------------MLETDHSRNDNLDDKSTVCYSEKTDSNVEKSTTSGLRRI----------------------------------------------------------------------------------------------------DAVNKVLSDYSSFTAFGVTFSSLKTALLVALFLQGYCTGLGGQISQSIQTYAANSFG------KHSQ--VGSINTVKSIVASVVAVPYARISDR-FGRIECWIFALVLYTIGEIISAATP-----TFSGLFAGIVIQQFGYSGFRLLATALTGDLSGLR--DRTFAMNIFLIPVIINT-WVSGNIVSSVAGN-----VAPYKWRW-GYGIFCIIVPISTLILVLPYVYA-------QYI----------------------------------------------------SWRSGKLPPLKLKE--------------------------------KGQAL--------RQ--------TL-----------WKFADDINLIGVILFTAFLVLVLLPLTIAGG------ATS----KWRE------GHIIAMIVVGGCL-G-FIFLI--WE-L-------------------R-----FAK-N----------P-FIPRVYL-GDPTIYVALLMEFVWRLGL-QIELEYLVTVLMVAFGESTLSAQRIAQLYNFLQSC-TNIVVGIMLH-F---------YPHP-KVFVVAGSLL-GVLGMGLL----YKYR----------------------------VV--Y------DGI--SGLIGAEIVVGIAGGMMRF-PMWTLVHASTT-YN------EMATVTGLLMSVYQIGDAVGASIAGAI-W--TQRL-AKELIQRLGS-------------------------SLGMAIYKSPLN------YLK--KYPIGSEVRVQMIES-YSKIQRLLIIVSISFAAFNAVL--CFFLRGFTVNKKQSL-----SAE-----------------------------------------------EREKEKLKIKQQSWLRRVIGY------------------------------------------------------------------------------ 'Saccharomyces paradoxus NRRL Y-17217 sapa c416 24437' ----------------------------------------------------------------------------------------------------------------------------MVETDLSRNDNLDDKSTVCYSEKADTDVDKSTASGLRRI----------------------------------------------------------------------------------------------------DAVNRVLSDYGSFTAFGVTFSSLKTALLVALFLQGYCTGLGGQISQSIQTYAANSFG------KHSQ--VGSINTVKSIVASVVAVPYARMSDR-FGRIECWIFALVLYTVGEIISAATP-----TFGGLFAGIIIQQFGYSGFRLLATALTGDLSGLR--DRTFAMNIFLIPVIINT-WVSGNIVSSVAGH-----TAPYKWRW-GYGIFCIIVPFSTLILVLPYAYA-------QYI----------------------------------------------------SWRNGKLPPLRLRE--------------------------------KGRTL--------RQ--------TL-----------WKFAEDVNLIGVILFTAFLVLVLLPLTIAGG------ATS----KWKE------GHIIAMIVVGGCL-G-FIFLI--WE-L-------------------R-----FAK-N----------P-FIPRVYL-GDPTIYVALLMEFVWRLAL-QIELEYLVTVLMVAFGESTLSAQRIAQLYNFLQSC-TNIVVGIILH-F---------YPHP-KVFVVTGSLL-GVLGMGLL----YKYR----------------------------VV--Y------DGI--SGLIGAEIVVGIAGGMIRF-PMWTLVHASTT-HN------EMATVTGLLMSVYQIGDAVGASIAGAI-W--TQRL-AKELIQRLGS-------------------------NLGMSIYKSPLN------YLK--KYPLGSEVRIQMVES-YSKIQRLLIIVSISFAAFNAVL--CFFLRGFTVNKKQSF-----TTE-----------------------------------------------EREKEKLKIKQQSWLRRVIGY------------------------------------------------------------------------------ Kluyveromyces_polysporus_DSM_70294_klpo_416.5 -------------------------------------------------------------------------------------------------------------------------------MEINIKHNQKENTEFEYSEELPSSTSESDHISSHSD----------------------------------------------------------------------------------------------------AESDKFGVHNVEIYAKYYSTPVKRFLIFFSLFTIAYAYGLDNSVRGTYQTLATSSYN------QHSL--LSTVSCIKAVISAAAQIWFARSADM-FGRTTILMISIVFYVVGTVVESQAV-----DVSKFAAGACLYAVGHSAIVLFSEVYVADFSNLN--WRVTAAAAPLLPNVINT-WISGDITAAIDEN----------WKW-GIGMWAFIFPLSCIPMGACILHM-------KYL----------AK-------------------------------------KNKDDLKVAFKKPEHYT--------------------------------WSQYL--------VD-------VFF-----------WKL----DLVGLLLLVAIFGMILIPFTLAGG------EEK----VWST------ARIIVPEVLGWAFAL-PLFLV--WE-I-------------------K-----FAR-Y----------P-LTPKDAL-KNRGIVSALVLVLFLQFAY-QMQSTYLYTVLLVAVDESKKSATRINKLFSFVSVI-TGFLSGFVVA-K---------VRRT-KEFIFFGIGV-WFISFGLM----IRYT----------------------------GG--L------DSH--VGIIVARCILGFGNGFLKF-PARASIQASAYSHE------MMAVMTSLFLAVSSIGSAFGDAVAGSI-W--TNVL-PGKISEGITN------------------------ETLADYAYGSPTK------FIL--KYKWDTPERQAVVEA-YKVIGRLLNIVGICLLVPLLIS--AFFLKN---R---RL-----EDV--------------------------------------------VSFDKFDKMNSENAEDSVLEETSKEKEKEKV----------------------------------------------------------------------- Kluyveromyces_thermotolerans_CBS6340_klth0d18150g -------------------------------------------------------------------------------------------------------------------------------------MSKDNASSAHADLKNEVYVDVEKVTPGCTL----------------------------------------------------------------------------------------------------KTTKSLVIRKTEIMAAQYDRWYHHAIILFSAFICGYGYGLDGSVRYVYTSYAVSSYS------DHPL--ISTITVVTAIISAASQIVFARLSDV-FGRLSLFITALLFYAVGTIIQSQAT-----DVQKYAAGAIFWSTGYVGLLLILILILSDFSSLR--WRLVYQFAPSWPYIINT-WFAGTVTARANPQ--E------HWSW-DIAMWAFIVPLSALPMIFCMLHM-------RFK----------AR-------------------------------------KTEQWAAIKDEKSFFQSHG------------------------------LIRTL--------VE--------LF-----------WKL----DIVGVLLMTISVGCILAPLTLAGG------VKS----KWSN------PHLIGPLVLGFVL-L-PLFMI--WE-S-------------------K-----AAK-Y----------P-VVPYGLI-KDRAVWGALGCQFLIGFIY-NAVAGYIYTILIVAVNESVKSATVISSLSSFVSTV-ASTFFSLYIT-R---------CTKL-KGYIIGGCGI-WMLAMGLF----YHYR----------------------------GG--E------FAH--SGIVGAMVIWGLGDTLLIY-PTTISVQSATS-HD------NMATVTALNYTLYRIGLATGAAVSGAI-W--SQTL-YKALLSRLQS------------------------VEQASAAYSTPFE------FIL--TYTWGTPERNAMVDA-YRHVQRYESIVALVFTVPLLFF--GLCLRD---P---PL-----TDK--------------------------------------VAQEDIDDGEFLDKNHDDPIAEWLVGKYRRLANKNL------------------------------------------------------------------------ Pichia_stipitis_CBS_6054_pist_igi19986137 -----------------------------------------------------------------------------------------------------------------------------------MSRDSSTEAP--------QALVEDPEKQSQKK----------------------------------------------------------------------------------------------------VFIESDAGDGTKREDQYLHGIH-LVFCFIAVCLSLFLEALDQTIVATILTTVGNKFD------DFDK--VGWLASGFLLAMAVCIQPFGKFSII-FGRKYTMVTAIVLFEAGSLMCALAK-----NMNVLIGGRVLAGIGAAGIQGMVFVIVTEVVPIE--KRPIGMAIVSCIFAVAS--VLGPLIGGAFTS--H--V---SWRW-AF---YINLPIGGIALAFLLWAF-------NPP-----------K--------------------------------------------------------------------------------------CTSSI--------VE--------EL-----------KTF----DYFGTFLLISGCVVFLLALTFGG-------NDF----SWHS------AAVILCFVLGGLL-L-IAFII--WNGW-------------------------FSK-N----------Q-IIAVELI-KIPQVVASIFAISGIFAAF-ILSMVFLPIYFQVIHGASAMGAGLHLLPMIVAVVL-SSICSGVAIQ-K---------SKYV-KPFSLVAGIL-GPIGFGLL-----AIL----------------------------GV--D------TSF--SAQVGLLIIGGVAVGAQMQ-PAIVSAQISAP-KTPG----STIMVTVLLNFSRSLVSALAADLGDVI-Y--ASSF-KNY----FKK-----AFKATTNTT----ILSDLQDVDISQ-LVSNTS------LLA----HLNPVTQHFVKTQ-IAKALRNVFYMGIGLAAITFVA--CFFITN---K---KL-----PEM-------------SDGA---------------ANAAEKEKEEKTELTSDSNDIQSEAVHEIAEGADFEKKSIQASGDESSTSITRK------------------------------------------------------------ Candida_parapsilosis_CDC_317_capa_02454 ----------------------------------------------------------------------------------------------------------------------------MSSSVNTEVKASSMDEEKQIYDDKHTPDNTSSELEHAIE----------------------------------------------------------------------------------------------------EEKSIGVLKAELLAAQWKHTFWYKLVLLISAFLVGYAYGLDSQIRYVFTGYATASWS------EHSL--LTTVNAITALTAAASQPVYARLSDV-FGRLELFIVAVLFYVVGTIIECQSP-----TINAYVAGAVLYQIGYSGVLIVLLFILSDFSTLR--WRLFFSICPALPFIINT-WISGNVTSAVGMN----------WKW-GIGMWAFIFPLACIPFVCCMIHM-------RWL----------AG-------------------------------------RTPEWVEFKKKETLYQKFG------------------------------FWGFM--------KY--------LF-----------WKL----DCIGLLLMVVSLGCLLVPLTLAGG------VSE----KWKQ------GNIIAPIVVGCVL-I-PVFCI--WE-L-------------------------FAK-D----------P-IIPVTLM-KDRGIWSAGLISLLFDFVF-AVEASFLYPVLVVGVNESQKSATRITTLTSFASTL-CCMLFGLVVV-Y---------IRRL-KPFVIFGCSL-WMVAFGIM----YHFR----------------------------SS--L------SAH--SGIIGGQIVMGIGTGFFSY-PITVSAQSCVN-HE------HMAVITSAIYTLYRIGYAVGSSVAGAI-W--SQTL-FKKLNKYLDT-------------------------ATATSVYTSPYV------FAD--TYPWGTPQREGATKA-YGEIQRLLMIVCLCFVAPMIAA--SFFLRD---K---KL-----GRE-----------------------------------------------QSIENVEEQDEQDSLLSFIKSLGGKRGRTEKA------------------------------------------------------------------- 'Candida tropicalis MYA-3404 catr 03960' ---------------------------------------------------------------------------------------------------------------------------MASNEPVLTQSSEPTPINTVEDTITPNQEQLERHDTNQSK----------------------------------------------------------------------------------------------------QKFKESDAGDGTRKEDHYLRGPRLILCFISLFLCLFLFALDQTIIATILTTVGTKFN------SFAQ--VGWLSSGFLLAMAVFIQPFGKLSII-IGRKWAMVVAVILFEAGSLMCALAN-----SMNVLIGGRVLAGVGGAGINSGVFVIASEVLPIN--KRPFALSIFAITFAVAS--VLGPLIGGAFTS--H--V---TWRW-AF---YINLPVGGVALIVFLYSF-------RPP-----------R--------------------------------------------------------------------------------------PKVDM--------KQ--------EM-----------KRF----DYFGTFLLISGCVVFLLALTFGA-------DEF----PWDS------GAVISCFIIGPVL-L-IAFCI--WN-F-------------------K-----FSK-N----------Q-IIGTEVV-KVPQIIASTLSISGIFTAF-IMSMIYGSIYFQVIQDSSPLGAGLHLLPTIVSVVL-CSLFSGIMVQ-K---------FRYV-KPFNIASGIL-GPVGCGLL-----SLL----------------------------QV--D------STF--SQQVGLLIVIGVSAGLAMQ-PSFLSAQIMAP-KSPS----GMIMTTIFINFFRSLLSAAGAVLADAV-Y--TASL-RNI----FKK-----NVAKLT-DP----VILQDLQRLDVSQLISSVE------IMK----ELHPETQHFIKTQ-IMDAIRNVYYTTIGFAAISLIA--CFFITN---K---KL-----PAD--------------------------------VEIRTSTEKDEEEGVGQETNDSLESSANEVDKRENSEDGQQI------------------------------------------------------------------------ Yarrowia_lipolytica_CLIB122_yali0f28017g ----------------------------------------------------------------------------------------------------------------------MGAKDETISPTTFSNLSDSSNTRSGTDNSPENDIIDGAHEKDAAT----------------------------------------------------------------------------------------------------TDVTPDTDAVARPTGPPPISNAKKGLIAGLLSLSVLIVALDQTIVTTSLPDIVAALK------SSSG--YSWVGAAYTLACAGVLPAYGRFADI-FGRKITLMVAILLFILGSGICGGAS-----SINMLIGGRVVQGLGGGGISALVNIIISDIVALH--QRGAFMGMLGATWAIGG--AIGPLIGGALTQ--N--V---SWRW-CF---YLNLPIAGFTMCMLFLLL-------KNN----------KG------------------------------------------LEYEN---------------------------------------DTRTV--------WQ--------KL-----------LKI----DFCGIILVAGATVLLLLALDWGG-------TTH----PWGS------GIIIAFLVVAFVL-Y-GIFLTLEWF---------------------QDQRENYPR------------P-IMPPSLF-ANKTRLGGYLFTFFHSIVF-MCISYFMPFMYQSVYGKSPMGSAVYLLPQAFVTGG-LSAGAGIFIA-K---------TGHY-LPVMWISSVI-IIVFTGML-----STL--------------------------------D------ETSNVGKRICYVMAWGAGIGPVFQ-APLVVIHTQVE-RK------NIAISTTTWSFVRMLGMSIGISIGGVV-F--QNQMEDQISDPAIIR-----------------QLPEWLLEPLSGTNAAAATQ------MLNNKGSDISAHVLSLVRYM-YSHAFKYVFYTCLGLCGGLLSV--LLIGKH-------QV-----KMR-------------------------------------------GDLGKKEKQEKREAENRALSEQPGESV---------------------------------------------------------------------------- Pichia_stipitis_CBS_6054_pist_igi16603947 ----------------------------------------------------------------------------------------------------------------------MSLASDDKESILPTSKDYGSTPLSQDNSEDSVAVNEKGDIDTSNK----------------------------------------------------------------------------------------------------KKYYESNAGDGSRAEDQHLTGLTLAVTLVSCVSCLFLVALDQTIVSTILTQVGDKFK------EFEK--IGWLTSGYLLPMATLAPSYGKVGIA-FGRKYTLLVAVIVFEIGSLISGLSN-----SMSMLIGGRVIQGIGGGCVQAMVVVILTESVPIS--RRPLSYMLLGVTFSLSS--VLGPFIGGAFAT--H--V---SWRW-CF---YINIPIGGMAAALLIFGF-------HPP-----------K--------------------------------------------------------------------------------------PEGNI--------RQ--------KL-----------AKI----DYSGTFLLTVGLVLVLLGLTFGG-------IDF----PWKS------AAVICSFVIGGLF-L-IAFCV--WN-F-------------------K-----FSK-N----------P-IIIPQIV-RIPPLMAACISGSFNFGFF-LANFTYLAVYFQVIFGATAWKSGVDLLPMIIAVTM-TSILNGVFIK-----------FTRYVKITMLISGVL-GPVGTGLL-----LLL----------------------------RK--D------SPL--ADRIGLLILCGISIGLQFQ-SSMLATQLCAP-PDITG---SLILSTIFLNFLKSTAAAISVSLAQLI-F--QASG-TSY----IKS-----LVNSLPRDS----AEYQALYGIPPKDLISTPR------IIN----TLPESARQMVLDQ-FMRALHNVFYLGLAFSIVALIG--AVFTTN---K---KI-----PKA--------------------------------SDIAKNSD-------VEKGNKDAATTEESEIISQIESTAKDQE----------------------------------------------------------------------- 'Kluyveromyces waltii NCYC2644 klwa 265-snap.3' --------------------------------------------------------------------------------------------------------------------------MTFDKEGFNVETLADEEKN--------NLGVSQHNDPIKKL----------------------------------------------------------------------------------------------------QSTKSLNIRKTELMASCYDRWYHHVFLLFAAFLCGYGYGLDGNIRSVYTSYAAASYA------AHPL--ISTLSVVTGVMSAASQIFFARLSDV-FGRLSLFVTAIAFYVVGTIIQSQAY-----DIQRYAVGSVFWSIGYVGILLMLILIVSDFSSLR--WRLLYQFAPSWPGIINT-WIAGTITARSNPQ--E------KWSW-NIGMWAFIIPLTCLPMILCMLHM-------RFK----------AR-------------------------------------RTEQWAELRNERSYYQTHG------------------------------LIKTL--------IE--------LF-----------WKV----DVVGILLMTASIGCVLAPLTLAGG------TGS----KWQN------PRVISPFVLGFVL-L-PIFLI--WE-K-------------------K-----WAR-D----------P-IIPYDLI-KDRAVWASLNSQFLIGFIY-MMAAGYIYNILIVGVNESIKSATTITILSSFVATA-ASPPFCLWIT-R---------CTRM-KGYIVAGCGL-WMLAMGLF----YHYR----------------------------GG--E------FAH--GGIVAAMVVWGLGDVLLIY-PITVSVQSATS-HD------NMAMVTALNYTTYRIGLSTGSAISGAI-W--TQTL-YKELFKRLGD------------------------ATLAVSAYSDPFK------FIT--TYTWGTPEREAVVQA-YRHVQRYETIVALVFTVPLLIF--VLFLRD---P---PL-----TDE--------------------------------------VAHGSIKDGEYVAKDHEDPIFSWFAGGWKRLVHKND------------------------------------------------------------------------ 'Candida tropicalis MYA-3404 catr 04131' ----------------------------------------------------------------------------------------------------------------------MSQHTPTTSQPQSSINDDNDIASLVISPQEQLHDLEKQQTNASSK----------------------------------------------------------------------------------------------------KFKEADAGDGTSKEDHYLHGTQ-LILCFVSLFLVLFIFALDQTIIATILTTVGTKFN------SFAQ--VGWLSSGFLLAMAVFIQPFGKLSII-IGRKWAMVVAIILFEGGSLMCALAS-----SMNVLIGGRVLAGVGGAGINSGVFVIASEVVPIN--KRPFALSIFSVTFAIAS--VLGPLIGGAFTS--H--V---TWRW-AF---YINLPVGGLALAVFLYSF-------RPP-----------T--------------------------------------------------------------------------------------PKVDI--------KA--------EL-----------LRF----DYFGTFLLISGCVVFLLALTFGT-------EEF----PWNS------SAVISCFVIGPVL-L-IAFCI--WN-F-------------------G-----FSK-N----------Q-IIGTEVV-KVPQIIASTLCISGMFSAF-IMSLIYGSIYFQVIKDASPLGAGLHLLPTVIAVVI-SSMASGILVQ-K---------LRFV-KPYNIASGIL-GPIGCGLL-----TLL----------------------------QV--D------SSF--SKQVGLLIIIGVSAGLAMQ-PSILSAQIKAP-KTPS----GMIMTTIFINFSRSILSAFGTVLADAV-Y--TASL-RNI----FKK-----NVAKLT-DP----EILQDLQKLNINELISSTE------ILK----TLNPETVHFVKTQ-IMDAIRNVYYTTIGFAVISFLA--CFFVTN---K---KL-----PAQ-------------VEMR---------------PKTEKKDE-------EDIEVQEETNETSQSSESLDKDLEKPSDK---------------------------------------------------------------------- Kluyveromyces_lactis_CLIB210_klla0d19941g ----------------------------------------------------------------------------------------------------------------------------------MDQKLQQEESLNNSMDGPMSKNAIMQVEVTADN----------------------------------------------------------------------------------------------------ASIDANTPDHNDNSNVRLMSGLRLYVCVAALVLATFIFALDVFIVNTIIDSVSASLG------GYSK--SGWLIAGYSLPNSLFSLIWGRTASL-LGFQASMTLSIFIFEVGSIVSASAT-----SMDNLIVGRVIAGVGGSGLQTLSLVIGSSIVEEK--NRAMIVSIVMSAFAAAS--LIGPFVGGAFTT--H--V---IWRW-CF---WINLPIGAVTALLFYFTY-------NPK-------------------------------------------------RLSAASRFTSCFKSVKALSF-----------------------------EKLAS--------WETYRCMGKNLL-----------FRF----DIVGFATGCAGVCLLLLGLTLGG-------EDD----SWKS------AIVICFLIVGFLL-S-VLSVV--YD-FYIFDKINPEPS--------N-----LSF-R----------P-MLVKGLL-NNRFILLPNLVTCASAIAF-SGYMLYSVQFFQLVMGSSAWNAGLHLIPLVIASIV-SAIICGGIMK-K---------TGQV-KPLMISTVSI-LLIGGGVS-----TLL----------------------------DN--H------SGN--SMQIGVWILPGFGLGAALQ-CALISSQLQID-KESPNSEIELVEVTAFNSFTKSLGSSIGGVLCTAI-F--TSSL-WSK----INA------------------------VKLEGYYGKSTNE------FVKYRLQHFDSRYSEASTI--FSDSVTNVFWMALAFAAFAFVC--SCLSST-------NT-----VEI-----------------------------------------------ADKQKVHSDRDMSLISDSKLEA----------------------------------------------------------------------------- 'Kluyveromyces waltii NCYC2644 klwa 298-snap.3' ----------------------------------------------------------------------------------------------------------------------------MVMSMKKVLDDEAIGLECSDLDGGSSSEKPSLTKGDKGR----------------------------------------------------------------------------------------------------QQYDYMKVKEMEIIKDVCSGNLARVFLLASAFLCGFAYYLDMVTRSVYTTYAANSYE------KHSL--LSTIQVINSVVGVGAQISFARLSDV-FGRLQMFVVGTILYVVGTIIQSQAH-----DVKVYAVGAIFYNTGFVGVSLLLILVLSDMSPLR--WRLFYQFTASFPCIIIS-WISGDIVEAANPM--K------NWSW-DIGMWAFIFPLSSLPFITYLFYA-------THI----------SS-------------------------------------KTKKWKDLRNKVETHKRN-------------------------------IILVV--------KD--------IF-----------NQI----DIVGTVLVTAALGLILVPLTLAGG------VSE----RWHE------PGIIATLVIGIAL-L-LVFLF--WE-A-------------------K-----FAK-N----------A-ALPFNLL-KDRGVWASIVAAFLEKMIY-AMISDYLYPVLLVSVNETNKSATRIVWLPTFMACL-CSVFFGLLVV-S---------VQRL-KVFTICGTFL-WIISIGLF----YQFR----------------------------GG--E------SSH--SGIIGASIVLGFGSAIFTQ-SIIVTLQAMAS-HD------NMASITGLYFMFAQVGAATGASISGAI-W--TQTM-YKQLLKQLKD------------------------SDLTMAVFASPYE------FIA--SYAWGTKERDLVIQA-YRHVQKVTMLVSLILTVPLLVS--VLFTKD---R---KL-----SDS---------------------------------------------VSSDASHEDDDPMYTWVCLKARAIKKRLLMFR--------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0c12122g ----------------------------------------------------------------------------------------------------------------------------------------MSDSDIKKTVTEGSVAPKDTWSIKTSD----------------------------------------------------------------------------------------------------SKGKDAGVHNIEIYADQYKSPYYRVALFFSIFLVAYAYGLDGNIRYTFQAYATSSYS------QHSL--ISTVNCIKTVIAAAGQICFARASDV-FGRLSILIIAVLFYVVGTVIESQAT-----NVSRFAAGACFYQLGLTGIILILEVIVMDFSNLN--WRLVASFVPALPFIINT-WISGDVTSAIGTN----------WEW-GIAMWAFILPLSCIPLVCCMLHM-------RYL----------AH-------------------------------------KNAPENLMSEFKLYKQMP-------------------------------WSEYL--------VE-------IFF-----------WKL----DFLGLLLLCVSFGLVLIPFTLAGG------LQT----KWKS------ASIIVPEVLGWCLAL-PLFLL--WE-G-------------------K-----YAR-N----------P-LTPWDLI-KDRGIFSALIIAFLINFIW-YMQGDYMYTVLIVAVHESIKSATRIVSLYSFVSVI-TGTLLGFVIV-K---------VRRT-KPFILFGVCC-WFLSFGLL----VHYR----------------------------GD--S------GAH--AGIVGSLCLLGFGAGFFTY-TTQASIQASTGSHQ------NMAVITALYLATYNIGSAVGNAVSGAI-W--TNVL-PQQLSKRLSD------------------------PEMASAAYGSPFT------FII--TYTWETLERQAVVHA-YRHVQKILCTVGVCFCVPLVLA--ALLLRNHKLESVVAL-----DDL-----------------------------------------------DEKNRVDDNENGNFLTKFFPSSRSNGETEVRERRVQV-------------------------------------------------------------- Yarrowia_lipolytica_CLIB122_yali0d15972g ------------------------------------------------------------------------------------------------------------------------MLNTCTNTTFTNNTMWAVQNPIRQAERDETDPPSPNPKWLSVA----------------------------------------------------------------------------------------------------GDGQQTRAAAEMEQITSLWNRTDFWLAWASMFLVSIALALEKMTFKVYSTFATSDFN------EMSL--LSALNVVQAVMYTATMTIMAKFADV-LGRFESFLLCVILFTMGEIMLAASS-----NISTYFAAHIFYVFGQVGIRFLQQVFAADTSSLR--NRLFFVVIPNFAYIFVP-WCSAPITNAIIKH--S------TWKW-GYGMWCIILPVVSVPVLVILFRL-------KRR--------------------------------------------------VKVVNGKKYDKEKYKGS-------------------------------RWNFI--------KE--------RL-----------LEF----DMIGLVLFTGGLSLLFLAVTLVK-------SQD----SWKQ------AHVLSMIIIGPIL-L-ILFPF--WE-M-------------------------YPK-Y----------P-FLPFSAM-KNKTLITGCSFCLVYSIAQ-NLYNPYYFPWLLVCKGLSVTAASNTSATLMVASVA-SSVVAAFILR-Y---------TNRV-KPVIVAGICI-YMLGLGLT----YHYR----------------------------QP--D------QSL--AKFIVTQAVEGVGQGFLQS-PSLVIIQASVP-KN------HVVSATAIFYAANSIGQVIGDAISGSM-Y--RQTY-PKKLADYAPF------------------LNATEIDQMVNN-VAAPLR------------YKWGTSERTAVIEA-FNHIYRKMLYGPMIVAAVCILI--ALALPN---I---DL-----SES-----------------------------------------------EDGSECTIDDDKSVIVHKSSSKTASAVIEKQL------------------------------------------------------------------- Yarrowia_lipolytica_CLIB122_yali0f20922g ------------------------------------------------------------------------------------------------------------------------------------MQSFKHYLQ--------VVFNPQVERAHDED----------------------------------------------------------------------------------------------------DTNVTDGVKEMEHLNKIFSKTE-LVFAWCSLLLVSVCIALESQTVNVYSTFATSHFN------ELSL--LSALAVVKSVMYTASRPTVAKLADV-LGRFEALVISVVFFTVGFIMLAACQ-----NIGTYFAAHIFYVSGQVGIQFMEQVFAADTSSLK--NRMFFVSLPNFAYLFAP-WIAAPITNAITKH--S------TWRW-GYGMWCIVMPVVAIPVCGIMLRL-------KFK----------AR---------------------------------------RLGLEYGK---------------------------------------SVRNF--------KE--------TM-----------RQF----DFIGLILFTGGLTLLFLAVTLATG------PKS-----WSQ------AHILAMIVIGPIL-L-VVFPF--WE-M-------------------V------PK-Y----------P-FMPFYII-KNRTMFTCCFLICCYSIAY-FLYGTYYMPWLMVCKNLSVTAATNTSVCFVVASTV-SSFVGAAYTK-L---------TNKV-KPVVCAGAAI-YLLGLGLT----YHYR----------------------------QP--H------HHL--GQFIVAQCVEGVGSGMMQM-PMLVMLQSVVS-HK------NVVSSTAIYLSIMTVGTIIGEAIAGSM-Y--RQSY-PKQ----LAI-----FAPFLTPAQ----------NHLVANNIGAALK------------YKWQTPERMMIVTA-FNDVYRRMLYPPIIVASFIFVG--TLTLPD---VNVSLM-----DDA--------------------------------QNNTDGENAMPHIKGDSESESMDDGMGVHHDSEDIEALAGTTSSEEASFGAEEEKKI--------------------------------------------------------- Saccharomyces_mikatae_IFO_1815_sami_b_c2470.2 ----------------------------------------------------------------------------------------------------------------------------------MMDPNNIYLSRKEKNGVELCVAEKNDPESDSFS----------------------------------------------------------------------------------------------------ESFIGFKIEESELISSQFNSLTYRILILSTAFLCGFGFSLDATLRSTYTGYATNSYA------EHSL--LSTIQVINAVVSVGSQVVFSRLSDY-FGRLELFTVASILYIIGTIVQSQAY-----SVSIYAAGAVFYNCGYVGVSLILTLILSDFSTLK--WRIFYQYSSYWPYIIIP-WVSGNIITAAKPE--K------NWTW-DIAMWAFIFPLSSLPLYCLIIYL-------KMK----------SV-------------------------------------KTPEWKALKERAHSVKRG-------------------------------FFKNI--------IF--------LF-----------WEL----DVIGIVLITVSTGCILVPLTLAAG------ASE----KWRS------SKIIDTLVSGGVL-F-LISMF--WE-A-------------------S-----YAH-N----------P-LLPFKLL-KDRGIWAPLGVAFFNYFTF-YIACDFLYPVLLVSMNESSTSAARILNLPDFVAST-ASPFYSLLIA-K---------SKRL-KISVIVGCAT-WMLSMGLF----YRFR----------------------------GG--Y------GSH--GGVISASVIMGFSGLLCSN-SVIVLLQAMTT-HS------RMAVMTGIHYTFSRIGAAVGASVSGGV-W--TQTM-PSRLYKLLGN------------------------DTLAAEAYESPYS------FID--SYPWGTVERYAVVEA-YKYVQRIMMIVGLICTIPLFAF--SLFMRD---P---EL-----IDK----------------------------------VTHEDFTEDGLAVPTDDVGIISRLQAFFKNSRHDKKAAL------------------------------------------------------------------------- Saccharomyces_cerevisiae_S288C_sace0g11000g -------------------------------------------------------------------------------------------------------------------------MKGEPKTYSMSDLSYYGEKAQQQNEKQQKQYVVRRNSTQSTS----------------------------------------------------------------------------------------------------KQNVSVVLEDNASESNELPKGFILYASLIALALSLFLAALDIMIVSTIIEEVAKQFG------SYSE--IGWLFTGYSLPNALLALIWGRIATP-IGFKETMLFAIVIFEIGSLISALAN-----SMSMLIGGRVIAGVGGCGIQSLSFVIGSTLVEES--QRGILIAVLSCSFAIAS--VVGPFLGGVFTS--S--V---TWRW-CF---YVNLPIGGLAFFLFLFFY-------NPGLSTFQETMDNIR---------------------------KFPSQFIEIVRNVAYHLLKIKGFSKLNG-------------------------------WRKPF--------ME--------LI-----------FMY----DIIEFVFCSAGFTCILLAFTFGG-------NRY----AWNS------ASIIILFIIGIVL-V-VLAGI--YD-FLVFPKFNIVKA--------T-----PHY-Q----------P-LMSWTNI-KKPGIFTVNIALFLTCAGY-ISQFTYIVQYFQLIYNDSAWRAAVHLVACIISTVV-TAILCGAITD-K---------TRQI-KPIIVISSIF-GVVGAGIL-----TLL----------------------------NN--N------ANN--SAHIGLLILPGVAFGGLAQ-SSMLASQIQLD-KKSPTFRSDFVSITTFNTFCKNLGQALGGVISNTV-F--SAAA-IKK----LTK-----ANIQLPDGT--------TVDNLVIY-RQTNFD-------------GSHSKLGNIISES-----LTDVFYMALGFYALSLIF--AVFASN---K---KV-----TAS------LR------------------------------------------------------------------------------------------------------------------------------------------ Saccharomyces_cerevisiae_EC1118_sace_b_1g1_5567g -------------------------------------------------------------------------------------------------------------------------MKGEPKTYSMSDLSYYGEKAQQQNEKQQKQYVVRRNSTQSTS----------------------------------------------------------------------------------------------------KQNVSVVLEDNASESNELPKGFILYASLIALALSLFLAALDIMIVSTIIEEVAKQFG------SYSE--IGWLFTGYSLPNALLALIWGRIATP-IGFKETMLFAIVIFEIGSLISALAN-----SMSMLIGGRVIAGVGGCGIQSLSFVIGSTLVEES--QRGILIAVLSCSFAIAS--VVGPFLGGVFTS--S--V---TWRW-CF---YVNLPIGGLAFFLFLFFY-------NPGLSTFQETMDNIR---------------------------KFPSQFIEIVRNVAYHLLKIKGFSKLNG-------------------------------WRKLF--------ME--------LI-----------FMY----DIIEFVFCSAGFTCILLAFTFGG-------NRY----AWNS------ASIIILFIIGIVL-V-VLAGI--YD-FLVFPKFNIVKA--------T-----PHY-Q----------P-LMSWTNI-KKPGIFTVNIALFLTCAGY-ISQFTYIVQYFQLIYNDSAWRAAVHLVACIISTVV-TAILCGVITD-K---------TRQI-KPIIVISSIF-GVVGAGIL-----TLL----------------------------NN--N------ANN--SAHIGLLILPGVAFGGLAQ-SSMLASQIQLD-KKSPTFRSDFVSITTFNTFCKNLGQALGGVISNTV-F--SAAA-IKK----LTK-----ANIQLPDGT--------TVDNLVIY-RQTNFD-------------GSHSKLGNIISES-----LTDVFYMALGFYALSLIF--AVFASN---K---KV-----TAS------LR------------------------------------------------------------------------------------------------------------------------------------------ Saccharomyces_cerevisiae_JAY291_sace_c_01814 -------------------------------------------------------------------------------------------------------------------------MKGEPKTYSMSDLSYYGEKAQQQNEKQQKQYVVRRNSTQSTS----------------------------------------------------------------------------------------------------KQYVSVVLEDNASESNELPKGFILYASLIALALSLFLAALDIMIVSTIIEEVAKQFG------SYSE--IGWLFTGYSLPNALLALIWGRIATP-IGFKETMLFAIVIFEIGSLISALAN-----SMRMLIGGRVIAGVGGCGIQSLSFVIGSTLVEES--QRGILIAVLSCSFAIAS--VVGPFLGGVFTS--S--V---TWRW-CF---YVNLPIGGLAFFLFLFFY-------NPGLSTFQETMDNIR---------------------------KFPSQFIEIVRNVAYHLLKIKGFSKLNG-------------------------------WRKLF--------ME--------LI-----------FMY----DIIEFVFCSAGFTCILLAFTFGG-------NRY----AWNS------ASIIILFIIGIVL-V-VLAGI--YD-FLVFPKFNIVKA--------T-----PHY-Q----------P-LMSWTNI-KKPGIFTVNIALFLTCAGY-ISQFTYIVQYFQLIYNDSAWRAAVHLVACIISTVV-TAILCGVITD-K---------TRQI-KPIIVISSIF-GVVGAGIL-----TLL----------------------------NN--N------ANN--SAHIGLLILPGVAFGGLAQ-SSMLASQIQLD-KKSPTFRSDFVSITTFNTFCKNLGQALGGVISNTV-F--SAAA-IKK----LTK-----ANIQLPDGT--------TVDNLVIY-RQTNFD-------------GSHSKLGNIISES-----LTDVFYMALGFYALSLIF--AVFASN---K---KV-----TAS------LR------------------------------------------------------------------------------------------------------------------------------------------ 'Saccharomyces cerevisiae RM11-1A sace d 00798' -------------------------------------------------------------------------------------------------------------------------MKGEPKTYSMSDLSYYGEKAQQQNEKQQKQYVVRRNSTQSTS----------------------------------------------------------------------------------------------------KQNVSVVLEDNASESNELPKGFILYASLIALALSLFLAALDIMIVSTIIEEVAKQFG------SYSE--IGWLFTGYSLPNALLALIWGRIATP-IGFKETMLFAIVIFEIGSLISALAN-----SMSMLIGGRVIAGVGGCGIQSLSFVIGSTLVEES--QRGILIAVLSCSFAIAS--VVGPFLGGVFTS--S--V---TWRW-CF---YVNLPIGGLAFFLFLFFY-------NPGLSTFQETMDNIR---------------------------KFPSQFIEIVRNVAYHLLKIKGFSKLNG-------------------------------WRKLF--------ME--------LI-----------FMY----DIIEFVFCSAGFTCILLAFTFGG-------NRY----AWNS------ASIIILFIIGIVL-V-VLAGI--YD-FLVFPKFNIVKA--------T-----PHY-Q----------P-LMSWTNI-KKPGIFTVNIALFLTCAGY-ISQFTYIVQYFQLIYNDSAWRAAVHLVACIISTVV-TAILCGVITD-K---------TRQI-KPIIVISSIF-GVVGAGIL-----TLL----------------------------NN--N------ANN--SAHIGLLILPGVAFGGLAQ-SSMLASQIQLD-KKSPTFRSDFVSITTFNTFCKNLGQALGGVISNTV-F--SAAA-IKK----LTK-----ANIQLPDGT--------TVDNLVIY-RQTNFD-------------GSHSKLGNIISES-----LTDVFYMALGFYALSLIF--AVFASN---K---KV-----TAS-----------------------------------------------LR------------------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_YJM789_sace_e_2117 -------------------------------------------------------------------------------------------------------------------------MKGEPKTYSMSDLSYYGEKAQQQNEKQQKQYVVRRNSTQSTS----------------------------------------------------------------------------------------------------KQYVSVVLEDNASESNELPKGFILYASLIALALSLFLAALDIMIVSTIIEEVAKQFG------SYSE--IGWLFTGYSLPNALLALIWGRIATP-IGFKETMLFAIVIFEIGSLISALAN-----SMSMLIGGRVIAGVGGCGIQSLSFVIGSTLVEES--QRGILIAVLSCSFAIAS--VVGPFLGGVFTS--S--V---TWRW-CF---YVNLPIGGLAFFLFLFFY-------NPGLSTFQETMDNIR---------------------------KFPSQFIEIVRNVAYHLLKIKGFSKLNG-------------------------------WRKLF--------ME--------LI-----------FMY----DIIEFVFCSAGFTCILLAFTFGG-------NRY----AWNS------ASIIILFIIGIVL-V-VLAGI--YD-FLVFPKFNIVKA--------T-----PHY-Q----------P-LMSWTNI-KKPGIFTVNIALFLTCAGY-ISQFTYIVQYFQLIYNDSAWRAAVHLVACIISTVV-TAILCGVITD-K---------TRQI-KPIIVISSIF-GVVGAGIL-----TLL----------------------------NN--N------ANN--SAHIGLLILPGVAFGGLAQ-SSMLASQIQLD-KKSPTFRSDFVSITTFNTFCKNLGQALGGVISNTV-F--SAAA-IKK----LTK-----ANIQLPDGT--------TVDNLVIY-RQTNFD-------------GSHSKLGNIISES-----LTDVFYMALGFYALSLIF--AVFASN---K---KV-----TAS-----------------------------------------------LR------------------------------------------------------------------------------------------------- 'Saccharomyces castelli NRRL Y-12630 saca 705.26' --------------------------------------------------------------------------------------------------------------------------MNFNQVTSTFEVSSDHVPA--------NDSGKVELTGKASA------------IKINELSSSAASSTIGS-----------------------------------------------------------------------EYIENSGVHNAEIYCKYYSHPIKRIMVFSSLFLIAFAYGLDNSVRTTYQTMATSSYS------QHSL--LSTVTCIKKVISAAAQLWFARSADM-FGRPTILTISIIFYVIGTIIECRAF-----DVSRYAAGACIFSLGHAGIVLVSELYVADFSNLN--WRVTAAAAQVLPNVITT-WISGNITGAIDKN----------WEW-GIGMWAFIFPLSCVPLIICIIHM-------RYL----------AR-------------------------------------KNNENLKVVFQKPNYMT--------------------------------WKEYC--------ID-------IFF-----------WKL----DIIGLILLVAFFSLILVPFTLAGS--------L----TWKS------PKIIVPEVLGWVLAI-PLYLI--WE-L-------------------K-----YAR-Y----------P-LTPWNSI-KDRGIWAPLIINLFQEFAY-YMQNTYMLTVLLVAVGQSKKSATRIIKFYSFVGVL-TAFFLGFVVA-K---------VRRT-KEFIALGIGI-WFVAFGLL----EHYE----------------------------GG--L------GAR--AGIIAAICILGFGNGFLKF-PCRASIQAAANSHA------MMGIATSLFQAVGSIGTAFGSAVAGGI-W--SNVL-PGEINKRITN-----------------------NSTLATYAYGSPTK------FIK--QYGWETTERQAVVSA-YKVVERLMAIVGLCLLVPMLVA--SIFLRN---R---RL-----EDV-----------------------------------------------VSFDKLDETFDEKSTDDEEVVRIKR-------------------------------------------------------------------------- Kluyveromyces_thermotolerans_CBS6340_klth0a01562g ----------------------------------------------------------------------------------------------------------------------------MVSFSILLHSGKNSRNKLKKMSLEGHPAKDAKDHAEQIL----------------------------------------------------------------------------------------------------ARRKDAGVNNIEVYAAQYSHFAYRVALFFSLFLVAYAYGLDGMVRSSLQAYATSSYG------SHSL--LATINCVKAVIAAAGQICFARASDI-FGRMTILALAVVLYAVGTIIDSQAT-----NITRYAAGACIYQLGYTGIILILEIIAMDFSNLN--WRLMASFVPALPFIINT-WISGNALEALGMN----------WKW-GIGMWAFIVPLSCVPLFACILHM-------RFL----------AH-------------------------------------KNAKDQLESEVLLYKHMP-------------------------------WSQYL--------VE-------VFF-----------WRL----DLLGLLLVCVVFGCILVPFTLAGS------LQS----KWKR------AEIIVPEVIGWCVAL-PLFLL--WE-G-------------------K-----YSR-H----------P-LVPWSLV-KDRGIWSALIIAIHINFVW-YMQGDYMYTVLMVAVNETAKSAARITSLYSFVSVI-TGFLLGGVIV-Y---------ARRT-KKFILFGIAC-WFVAFGLL----VHYR----------------------------GD--S------SSH--SGIVGSLCLLGFGAGFFTY-TTQTSIQASTKSHQ------DMAVITALYLSHYNIGSALGASISGAI-W--TNIL-PRELRKRITD------------------------VATYTLAYGSPFV------FIE--EYLWGTPERMEVVAA-YRVVQRILSIVGLCFCVTLLLS--AFFLRD---H---RL-----ENA--------------------------------VALEDVDEKSSRKSDELEARIEDNTETKGFERYGI------------------------------------------------------------------------------- Pichia_stipitis_CBS_6054_pist_igi16606996 -----------------------------------------------------------------------------------------------------------------------MSDIHRDTLERHVSAEVHKSLSDDTATKESLDVSNDVQDASSEV----------------------------------------------------------------------------------------------------EEKSIGVLKAEIIAAQWAGKWYYQAILLFSAFLVGYGYGLDGQIRYVFTGYATASYA------EHSL--LTTIGVVTAVAAAACQPVYARLSDV-FGRFELFIVSIVFYVVGTIIESQSK-----SVQIYAAGSVFYQIGYTGVILIIMCILADFSSLK--WRLFYLFVPTFPFIINT-WISGDVTSALGMD----------WSW-AIGMWAFIFPLLCLPMIGCMLHM-------RWL----------AG-------------------------------------RTEEWRQFRIRQTKFQELG------------------------------PVGFA--------VY--------LF-----------WKL----DIIGLLLLIVCLGCLLVPLTIAGG------VKS----KWQD------GSIIAPIVIGGLL-L-PVFGF--WE-S-------------------Y-----GAR-H----------P-IAPFHLL-KDRGVWAALVISFLLNFIS-AIESSYLYAVLLVAVDETQKSATRITSLSSFVSVI-GGVFFGLFVV-K---------WRRL-KGFIIFGCAI-WMVSLGIL----LHFR----------------------------SG--T------SAT--AGIIGGVCLMGFGTTFFSY-PVNVSMQTCTT-HE------HMAVIISLGLTVYRIGYAAGSSVAGAV-W--TQAL-YDKLLDKLGN------------------------AELALAAYTDPYT------FII--KYTWDTPERQDVVAA-YRELQRLLIIIPLVFCVPMLFA--GLFLRD---H---KL-----NDN-----------------------------------------------QSNKDIEKADNNESLGGYIKNSLNFKKNSEKQ------------------------------------------------------------------- Saccharomyces_cerevisiae_S288C_sace0c00110g --------------------------------------------------------------------------------------------------------------------------------MSSSVVGASSNKKSGIRQSCEIIERERHSNDDTYS----------------------------------------------------------------------------------------------------MTSTFFKLKENEIMSAQFDSLKYKILLISTAFVCGFGISLDYTLRSTYTGYATNSYS------EHSL--LSTVQVINAVVSVGSQVVYSRLSDH-FGRLRLFLVATIFYIMGTIIQSQAT-----RLTMYAAGSVFYNCGYVGTNLLLTLILSDFSSLK--WRMFYQYASYWPYIIIP-WISGNIITAANPQ--K------NWSW-NIAMWAFIYPLSALPIIFLILYM-------KYK----------SS-------------------------------------KTAEWRSLKEQARKERTGG------------------------------LFENL--------VF--------LF-----------WKL----DIVGILLITVSLGCILVPLTLANE------TSQ----KWHN------SKIIATLVSGGCL-F-FIFLY--WE-A-------------------K-----FAK-S----------P-LLPFKLL-SDRGIWAPLGVTFFNFFTF-FISCDYLYPVLLVSMKESSTSAARIVNLPDFVAAT-ASPFYSLLVA-K---------TRKL-KLSVIGGCAA-WMVCMGLF----YKYR----------------------------GG--S------GSH--EGVIAASVIMGLSGLLCSN-SVIVILQAMTT-HS------RMAVITGIQYTFSKLGAAIGASVSGAI-W--TQTM-PNQLYKNLGN------------------------DTLAEIAYASPYT------FIS--DYPWGSPERDAVVES-YRYVQRIIMTVGLACTVPFFAF--TMFMRD---P---EL-----IDK----------------------------------ATHEEFTEDGLVVLPDEENIFSQIKALFRHNRSNKKLGC------------------------------------------------------------------------- Saccharomyces_cerevisiae_S288C_sace0k07414g --------------------------------------------------------------------------------------------------------------------------------MSSSVVGASSNKKSGIRQSCEIIERERHSNDDTYS----------------------------------------------------------------------------------------------------MTSTFFKLKENEIMSAQFDSLKYKILLISTAFVCGFGISLDYTLRSTYTGYATNSYS------EHSL--LSTVQVINAVVSVGSQVVYSRLSDH-FGRLRLFLVATIFYIMGTIIQSQAT-----RLTMYAAGSVFYNCGYVGTNLLLTLILSDFSSLK--WRMFYQYASYWPYIIIP-WISGNIITAANPQ--K------NWSW-NIAMWAFIYPLSTLPIIFLILYM-------KYK----------SS-------------------------------------KTAEWRSLKEQARKERTGG------------------------------LFENL--------VF--------LF-----------WKL----DIVGILLITVSLGCILVPLTLANE------TSQ----KWHN------SKIIATLVSGGCL-F-FIFLY--WE-A-------------------K-----FAK-S----------P-LLPFKLL-SDRGIWAPLGVTFFNFFTF-FISCDYLYPVLLVSMKESSTSAARIVNLPDFVAAT-ASPFYSLLVA-K---------TRKL-KLSVIGGCAA-WMVCMGLF----YKYR----------------------------GG--S------GSH--EGVIAASVIMGLSGLLCSN-SVIVILQAMTT-HS------RMAVITGIQYTFSKLGAAIGASVSGAI-W--TQTM-PNQLYKNLGN------------------------DTLAEIAYASPYT------FIS--DYPWGSPERDAVVES-YRYVQRIIMTVGLACTVPFFTF--TMFMRN---P---EL-----IDK----------------------------------ATHEEFTEDGLVVLPDEENIFSQIKALFRHNRSNKKSGC------------------------------------------------------------------------- Saccharomyces_cerevisiae_JAY291_sace_c_04015 --------------------------------------------------------------------------------------------------------------------------------MSSSVVGASSNKKSGIRQSCEIIERERHSNDDTYS----------------------------------------------------------------------------------------------------MTSTFFKLKENEIMSAQFDSLKYKILLISTAFVCGFGISLDYTLRSTYTGYATNSYS------EHSL--LSTVQVINAVVSVGSQVVYSRLSDH-FGRLRLFLVATIFYIMGTIIQSQAT-----RLTMYAAGSVFYNCGYVGTNLLLTLILSDFSSLK--WRMFYQYASYWPYIIIP-WISGNIITAANPQ--K------NWSW-NIAMWAFIYPLSALPIIFLILYM-------KYK----------SS-------------------------------------KTAEWRSLKEQARKERTGG------------------------------LFENL--------VF--------LF-----------WKL----DIVGILLITVSLGCILVPLTLANE------TSQ----KWHN------SKIIATLVSGGCL-F-FIFLY--WE-A-------------------K-----FAK-S----------P-LLPFKLL-SDRGIWAPLGVTFFNFFTF-FISCDYLYPVLLVSMKESSTSAARIVNLPDFVAAT-ASPFYSLLVA-K---------TRKL-KLSVIGGCAA-WMVCMGLF----YKYR----------------------------GG--S------GSH--EGVIAASVIMGLSGLLCSN-SVIVILQAMTT-HS------RMAVITGIQYTFSKLGAAIGASVSGAI-W--TQTM-PNQLYKNLGN------------------------DTLAEIAYASPYT------FIS--DYPWGSPERDAVVES-YRYVQRIIMTVGLACTVPFFAF--TMFMRD---P---EL-----IDK----------------------------------ATHEEFTEDGLVVLPDEENTFSQIKALFRHNRSNKKSGC------------------------------------------------------------------------- 'Saccharomyces cerevisiae RM11-1A sace d 05343' --------------------------------------------------------------------------------------------------------------------------------MSSSVVGASSNKKSGIRQSCEIIERERHSNDDTYS----------------------------------------------------------------------------------------------------MTSTFFKLKENEIMSAQFDSLKYKILLISTAFVCGFGISLDYTLRSTYTGYATNSYS------EHSL--LSTVQVINAVVSVGSQVVYSRLSDH-FGRLRLFLVATIFYIMGTIIQSQAT-----RLTMYAAGSVFYNCGYVGTNLLLTLILSDFSSLK--WRMFYQYASYWPYIIIP-WISGNIITAANPQ--K------NWSW-NIAMWAFIYPLSALPIIFLILYM-------KYK----------SS-------------------------------------KTAEWRSLKEQARKERTGG------------------------------LFENL--------VF--------LF-----------WKL----DIVGILLITVSLGCILVPLTLANE------TSQ----KWHN------SKIIATLVSGGCL-F-FIFLY--WE-A-------------------K-----FAK-S----------P-LLPFKLL-SDRGIWAPLGVTFFNFFIF-FISCDYLYPVLLVSMKESSTSAARIVNLPDFVAAT-ASPFYSLLVA-K---------TRKL-KLSVIGGCAA-WMVCMGLF----YKYR----------------------------GG--S------GSH--EGVIAASVIMGLSGLLCSN-SVIVILQAMTT-HS------RMAVITGIQYTFSKLGAAIGASVSGAI-W--TQTM-PNQLYKNLGN------------------------DTLAEIAYASPYT------FIS--DYPWGSPERDAVVES-YRYVQRIIMTVGLACTVPFFAF--TMFMRD---P---EL-----IDK----------------------------------ATHEEFTEDGLVVLPDEENIFSQIKALFRHNRSNKKLGC------------------------------------------------------------------------- Saccharomyces_cerevisiae_YJM789_sace_e_0517 --------------------------------------------------------------------------------------------------------------------------------MSSSVVGASSNKKSGIRQSCEIIERERHSNDDTYS----------------------------------------------------------------------------------------------------MTSTFFKLKENEIMSAQFDSLKYKILLISTAFVCGFGISLDYTLRSTYTGYATNSYS------EHSL--LSTVQVINAVVSVGSQVVYSRLSDH-FGRLRLFLVATIFYIMGTIIQSQAT-----RLTMYAAGSVFYNCGYVGTNLLLTLILSDFSSLK--WRMFYQYASYWPYIIIP-WISGNIITAANPQ--K------NWSW-NIAMWAFIYPLSALPIIFLILYM-------KYK----------SS-------------------------------------KTAEWRSLKEQARKERTGG------------------------------LFENL--------VF--------LF-----------WKL----DIVGILLITVSLGCILVPLTLANE------TSQ----KWHN------SKIIATLVSGGCL-F-FIFLY--WE-A-------------------K-----FAK-S----------P-LLPFKLL-SDRGIWAPLGVTFFNFFTF-FISCDYLYPVLLVSMKESSTSAARIVNLPDFVAAT-ASPFYSLLVA-K---------TRKL-KLSVIGGCAA-WMVCMGLF----YKYR----------------------------GG--S------GSH--EGVIAASVIMGLSGLLCSN-SVIVILQAMTT-HS------RMAVITGIQYTFSKLGAAIGASVSGAI-W--TQTM-PNQLYKNLGN------------------------DTLAEIAYASPYT------FIN--DYPWGSPERDAVVES-YRYVQRIIMTVGLACTVPFFAF--TMFMRD---P---EL-----IDK----------------------------------ATHEEFTEDGLVVLPDEENIFSQIKALFKHNRSDKESGC------------------------------------------------------------------------- 'Saccharomyces paradoxus NRRL Y-17217 sapa c403 13053' --------------------------------------------------------------------------------------------------------------------------------MSSGVISSSNDKKCETRQFYEVTEREKHTNDDTYS----------------------------------------------------------------------------------------------------ITSTFFKLKENEIISAQFDSLKYKILLIITSFLCGIGLSLDYTLRSTYTGYATNSYS------EHSL--LSTVQVVNAVVSVGSQVVFSRLSDY-FGRLKLFSIATIFHIMGTIIQSQAT-----SLTMYAIGSVFYNCGYVGVNLLLILILSDFSSLK--WRMFYQYTSYWPYIIIP-WISGSIITAANPE--K------NWSW-NIAMWAFIYPLSALPIMFLILYM-------TYK----------SS-------------------------------------KTPELRSLKEQARKEKISG------------------------------LFRNL--------MF--------LI-----------WKL----DVVGIVLITVSLGCVLVPLTLANE------VSQ----KWQN------PKIIGTLVVGGCL-F-VIFVF--WE-A-------------------K-----FAR-A----------P-LLPFKLL-SDRGIWAPLGVTFFNFFTF-FISCDYLYPVLLVSMKESSTSAARIVNMPDFVAAT-ASPFYSLLVA-K---------TRKL-KLSVIGGCAA-WMVCMGLF----YQYR----------------------------GG--T------GSH--GGVIAASIIMGLSGLLCSN-SVIVILQAMTT-HN------RMAVVTGIQYTFSKVGAAVGASVSGAV-W--TQTM-PNQLYKHLGN------------------------DTLAEAAYTSPYT------FIK--KYPWGSPERNAVGES-YKYVQRIMMTVGLICTVPFFVF--TLFMRD---P---EL-----IDK----------------------------------ATHEEFTEDGLVVLPDQDNIFSQIKALFKRSRSNKEVDG------------------------------------------------------------------------- Kluyveromyces_thermotolerans_CBS6340_klth0d00506g -----------------------------------------------------------------------------------------------------------------------------MSIEKETATGVQSSAYPIEADDKDSHRELNEYGLPDKL----------------------------------------------------------------------------------------------------RVTRHIVIKKTEILAAQYDSWYYRVILLFAAFICGYGYGLDGNIRYIYTGYATNAYS------EHSL--LSTIGVVNNVIGAASQLVYARLADT-FGRLSLFITAIVFYAVGTIIQSQAY-----DVQRYAAGAVFYNIGYVGVILVLLLMLSDFSSLR--WRLLYTIVPTWPFIINT-WISGNITSAAKPE--T------NWSW-DIGMWAFIFPLSCVPLIACMIHM-------RIK----------AR-------------------------------------KTPEWIALKQEKSYFQTNG------------------------------LWDTL--------VE--------LF-----------WKL----DVVGVLLLIATLGCILVPLTLAGG------YNS----KWNN------PHIIGPFVLGFVL-V-PILMF--WE-M-------------------R-----WAR-D----------P-LVPYGLI-KDRGVWSALAISFLNYFIF-ALAAGYLYAILLVAVDESVKSATRISSLSSFVSVV-WSPIFSLFIT-R---------QKKL-KPYIVLGCAM-WMVGIGLL----YHYR--------------------------------G------GSYAHSGIIGALCVWGAGSTMWTY-PVNISVQSATS-HE------NLATVTALNYTLYRIGGAVGTAVSGAI-W--TQTL-YKQLLKRLGD------------------------ADLAAAAYASPYT------FIV--SYAWGTPQREAVVGA-YRHVQRYETIVALVFCAPLVIF--AMCLRD---P---DL-----TDE--------------------------------------VAHSGLEKGEYIVKDQTDPISDWFSSKWSRLRERKEN----------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0g03300g -----------------------------------------------------------------------------------------------------------------------------MCKGLAISQAGCVPEHTPSDNEKQTYNELNEYGIPDKL----------------------------------------------------------------------------------------------------KSTKSLVIRKTEILAAQYDTWFYRSILLFSAFLCGYGYGLDGSVRYIYTGYATNSYA------EHSL--LSTIAVINAVISAAAQIVYARLADV-FGRLYLFITAVIFYVVGTIIQSQAY-----DVQRYAAGAVFYNTGYVGVVLVLLLILSDFSSLK--WRLFYQFVPTWPFIINT-WIAGDITSRANPQ--E------NWSW-DISMWAFIFPLSALPIICCMLHM-------RIK----------AR-------------------------------------KTPEWQVLSEEKSFYQTHG------------------------------FIQTL--------VQ--------LF-----------WKL----DVIGVLIMTVSLGCILVPLTLAGG------YSS----KWQN------SQIIGPIVLGFVL-I-PMYIY--WE-S-------------------K-----WAK-E----------P-MAPFKLL-KDRGVWAALGISFLIDFIF-YMAADYLYAVLLIGVNQSVKSASRISSLSSFVSTV-ASPFFALIIT-R---------STRL-KPYIITGCSL-WMLAMGLL----YHFR----------------------------GG--S------ESY--SGIVGALCVWGIGTTMFTY-PVNVSVQSVTS-HE------NMATVTALNYTLYRIGAAVGAAVSGAI-W--TQTL-YKDLLNRLDD------------------------AALAMSAYSEPYS------FII--THTWNTPERDAMVQS-YRYVQRLETIVALVFTVPLLVF--SFFLRD---P---PL-----TDK--------------------------------------VAQDNIEEGEYINVNHNDPITDWFSSRFERLRGKKEN----------------------------------------------------------------------- Kluyveromyces_polysporus_DSM_70294_klpo_358.4 -----------------------------------------------------------------------------------------------------------------MTSSSDSKFDGKINETVLQEQTTEDSNQFNSSQLDSNQPDSNQPDLKNYD----------------------------------------------------------------------------------------------------LYHKDAGVNNIEVYAEQYSSPIYRVMLFFSLFLVAYAYGLDGSVRYTYQAQATSSYS------QHSL--LSTVNAITTVIAAAGQICYARASDI-FGRMTILIIGLVFYAVGTIIESQAT-----NVTRFAVGSCFYQLGYTGVILSLELIAMDFSNLN--WRLFASFVPALPFIINT-WISGNVSGAVGQH----------WKW-GIGMWAFIVPLSAIPLGCCLLHM-------RWL----------AH-------------------------------------KNAKDRLKSEFRTYRDMG-------------------------------WFAYI--------VD-------VFL-----------WKL----DFIGLLLLCATFGCILVPFTLAGG------LQD----KWKT------AHIIVPEVIGWCVAL-PIFLL--WE-I-------------------K-----FSK-V----------P-LTPWALI-KDRGIFFALVIAFHINFIW-YMQGDYMYTVLIVSVNESIKSATRITSLYSFVSVI-TGTLLGLVII-K---------VRRT-KPFIIFGVSC-WFIAFGLL----VHYR----------------------------GS--S------SSH--SGIVGSLCLLGFGAGFFTY-TTQASIQASVKYHS------KMAVITALYLAMYNIGSAVGAAVSGAI-W--TNVL-PKQISKRIAN------------------------ETLAAEAYGSPFT------FIL--TYTWDTPERQAVVVS-YRYTQKILCIVGLCFCSTLLGA--ALFLRN---H---KL-----ESV-----------------------------------------------VALSELENTPNSDEQGSFADNDKNVN------------------------------------------------------------------------- 'Lodderomyces elongisporus NRRL YB-4239 loel 00428' -------------------------------------------------------------------------------------------------------------------------MTKDSISSRFSSTSSSGTTADNVIEQKEAGPVPLDIESQKSH----------------------------------------------------------------------------------------------------NHFKESDAGDGTNREDQYIHGIKLVLCFVSLFLCMFLFALDQTIVSTILSTVGNKFN------SFEN--VGWLSSGFLLTMAVFIQPFGKLSII-FGRRWTMVAAVIIFEAGSLMCALAP-----TMNVLIGGRVLAGIGGAGIQGLSFVIVSEVVPIP--KRPIGMAIMSVTFAVAS--VLGPLIGGAFTT--H--V---TWRW-AF---YINLPVGGLALVVFLYSF-------RPP-----------T--------------------------------------------------------------------------------------PKGNY--------FQ--------QL-----------KEF----DYFGTFLLIAGCVLFLLALTFGS-------SDF----SWDS------GAVISCFVLGPIL-I-ICFCI--WN-F-------------------R-----FSK-N----------Q-VIATDVI-MTPQIIASSFGIAGIFTAF-ISVMIYAAVYFQVIRDASAIGAGLHLLPCIIAVVI-SSIVSGAMIQ-K---------LKFV-KPWAIVSGVL-APIGAGLL-----ALL----------------------------RV--D------SSF--SQQVGFLILIGVATGLQFQ-PALMSAQIKAP-KTPG----GTIMTTIFVNFFRCILSATGATLSDAV-Y--TSSL-KNN----FRK-----AMATAPPEI------IEGLGNVELSSIMSSNA------IIK----TLDPTTQKFVKTI-MMKGITNVFYMCIGFAAITTLA--VPFITN---H---KL-----PDM---------ASLAKREA---------------KAEAEEQDVDVTEEKNEMREAETGPEEEKEGEARAIDSKVVD------------------------------------------------------------------------ 'Lodderomyces elongisporus NRRL YB-4239 loel 02353' -----------------------------------------------------------------------------------------------------------------MSSSLEHKTSSSRSGSVSGSNLDEKAPVYDDKNSHFNDNTTNDVVEQAVE----------------------------------------------------------------------------------------------------APKSIGVIKAELLAEQWKHTFWYKLVLLFSAFLVGYAYGLDSQTRYVYTAYATASWS------EHSL--LTTVNAITALTAAAAQPVYARLSDV-FGRLELFIVAVLFYVVGTIIESQSP-----TINAYVAGAVLYQIGYSGIIMVLLFILSDFSSLR--WRLYFSLCPSFPFIINT-WISGNVTEAVGTN----------WGW-GIGMWAFILPLACIPFLCCMIHM-------RWL----------AG-------------------------------------KTEEWKVFKQRQTKFQELG------------------------------FVGFI--------KY--------LF-----------WRL----DVIGLILMVVSLGCLLIPLTLAGG------TQE----KWKQ------GNIIAPIVIGAVL-I-IVFCV--WE---------------------N-----FAK-D----------P-ILPLSLM-KDRGIWSGAVISFLFDFVY-AVEASFLYTVLIVAVNESMKSATRISSVSSFASVV-CGFFFGLFVA-Y---------FRHM-KPFIIFGCSL-WMVAFGLM----YNYR----------------------------ST--L------SAH--AGIIGAMVVMGIGTGFFTY-PITVSAQSCVS-HE------HMAVVTSALYTLYRVGYAVGASVAGAI-W--SQTL-FKKLSEHLPT-------------------------DLATSVYSDPYT------FAS--TYAWGTDEREGAVKA-YGEVQRILMIVCLCFVAPMILS--AFFLRD---H---EL-----TRE-----------------------------------------------QSLEQVEEKEKQETLGGFFENFGRTRAERV--------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0f00792g ----------------------------------------------------------------------------------------------------------------------------MGKELSSSAQDVVEYKDIVIDCEKPLTNGDSDGNVPDRL----------------------------------------------------------------------------------------------------RVTKSLVIRKTEILAAQYDSWYYRVILLFSAFICGFGYGLDSNIRYIYTGYATSSYA------QHSL--LSTVAIINNLLSAASQIFYARLSDV-FGRLSLFVVSMVFYVIGTIIQSQAY-----DVQKYAAGAVFYNIGYVGLFLILVLILSDCSSLK--WRLFYQYAPTWPFIIIT-WISGNIISRANPI--E------NWSW-GIGMWAFIFPLTCLPILFCMLHM-------RFK----------AR-------------------------------------KTPEWQDLSSQKSFFQTHG------------------------------IVQAL--------VQ--------LF-----------WKL----DVVGIFIMTISLGCILVPLTLAGG------SSS----KWQN------SEIIGPLVLGFVL-V-PVFIY--WE-S-------------------K-----WAK-D----------P-LAPFELL-KDRGIWASMCFNFLMDFVY-CMAAGYLYPVLIVAVDESTKSATRITSLASFVSTV-ASPFMGYAVS-R---------STRL-KPYIVSGCGM-WFLATGLL----YHYR----------------------------SG--L------ESH--SGIIGGLVLLGLGCTLSIY-PINVSAQSLTS-HE------NMASVTALNYTVYRIGGAVGVAVSGAI-W--TQTL-YNDLLKRLGD------------------------ATLAMSAYSAPYS------FVL--TYGWDTPVRQAVVEA-YREVQRLEVLIALIFTAPLLLS--SLFLRD---P---PL-----TDQ--------------------------------------VGQENIKDGEYVATGYNDPITDWLTGKFKFLKRKRQD----------------------------------------------------------------------- Kluyveromyces_thermotolerans_CBS6340_klth0b00594g -----------------------------------------------------------------------------------------------------------------MSVCLDNQTTASLSDREVVEGTKEDIHEKVTGGILEKADSANSGANSVAK----------------------------------------------------------------------------------------------------DSENGQAAPSEPETAISPLTGLRFYVCFASLALSLFLAALDILIVGTIMETVAAKFN------GYSM--TGWLVTGYNLPNALLSLLWGRFGTV-AGFKTSMLLSIVIFEVGSLIAAAAT-----SMTMLIGGRVISGIGGSGIQTLCFVITSTLVTDR--TRGTAISILSCAFAVAS--VAGPFLGGAFAT--H--V---TWRW-CF---YINLPIGGLAFFFFLFSY-------NPN----------GE-----------------------------NTFENFKILLGRIKRISYSQLLTVSF-------------------------------YRRLF--------RT--------LV-----------FKF----DFFEFALSSAGFTLVLLALTFGG-------NRY----DWNS------GTIIAYFVVGILL-I-IASFV--YD-FVVFDRVKPQTD--------R-----IPY-L----------P-LLSWNVI-SKPGVLIPNIANFCTCFCY-NMQVVYIVQYFQLVWGDSAWKASIHLIAPVISTVI-TVLFCGIITR-K---------TGHV-KILLVVGGIV-IPVASGIL-----TLL----------------------------GP--K------SSS--SAKIGLLILPGISFGSVMN-GSLLSSQLQIQ-KNHPLFRFDFIAVTTFNAFVKMLGMAFGGIMSNMI-F--TTSV-RNE----LSK-----IKPPLPHSQ--------SVDGLISW-WYKNYA-------------GRDSAEVHV-----FMNGIKDVFWAALGLAAIAAVA--CFCSSN---K---KV-------------------------------------------------------DIEKPEGDEEKNGK------------------------------------------------------------------------------------- 'Kluyveromyces waltii NCYC2644 klwa 331-snap.3' ----------------------------------------------------------------------------------------------------------------------MSEKPAIQLSSALQDDHSEIDGKTNVAEKQCDKDATHQHGLTDKL----------------------------------------------------------------------------------------------------QMTKRIVIRKTELMANQYDNWFLKSLFLFSAFICAFSYGLDSIIRNIYMTYAMNSYS------THSL--LSTVSVISLTISAVAQIFFAGLSDV-FGRLSMFIVAIMFYVVGTIIQSQAY-----DVQRYAAGSIFYYIGLVGSMFEITLILSDCSSLK--WRLFYSFVPAWPALVTV-WISGNVVSVANPL--E------NWSW-GIAMWAFIFPASCLPIIGCLLHM-------RWK----------LR-------------------------------------NNPEWIELQEEKTYFQTHG------------------------------LVQTL--------KQ--------LF-----------WKL----DVVGVLLFSISTGCILVPLTLAGG------AST----QWRS------AKVIAPFVLGFLL-V-PVFIY--WE-S-------------------K-----LAL-V----------P-LAPFKML-KDRGIWAPLVITFLICYIY-MMAAGYLYTILVVAGNESPLSATRITSLYSFVAAV-FSPVVGIFVA-R---------FTRL-KPFAVFGCSL-YFVTMALF----YHFR----------------------------GG--T------DTG--KGVIGAMVIWGITSCFFNY-PINISMQTVTS-HE------NMATVTAFGLTIFRIGGAVGAAVSGAI-W--TQSL-YPRLLKTLGD------------------------PNMAIEAYSMPLS------FVL--KHEWGTSAREGMVEA-YRYVQRYEVLVGLIFVAPMFLL--TFFLRD---P---PL-----TED-----------------------------------------YGQKLDDNEYLKQDDPITDWLAERFSRFKKHD------------------------------------------------------------------------- Pichia_pastoris_GS115_pipa_4g02960 -----------------------------------------------------------------------------------------------------------------MPEQNSESEALLRAEELLPPNILDTSTGVEGIVANEIATENELTNRVEPEVSSTYGAASQASENEENVGTSSSPSVSLR-----------------------------------------------------------------------RKKVKKRKSEQFDASGYAVPPPQLYFILGSIFMGAFLAALDSTVVTTLLTVISSDLD------ALPK--FSWIATSYLLAMAAFQPLFGKLSDI-FGRKCLLILCNLLFSCGCLICALPKHFGG-TFTTLIVGRFLTGLSSGGLTTLGTIAMSDLISLR--KRGIFQGIANIFFALGA--STGGLVGGFISD--A--Y---GWRW-VF---LGQVPLAFIGAVVVYLFM-------NLP---------------------------------------------------SGSLGLGA---------------------------------------QDTDT--------KS--------KL-----------KRI----DVLGSVTLITALVCAMLAADLGG-------QKL----LYKT-------WSFAALVTGFVA-FSLVFAY--VE-L-------------------------YSATE----------P-IVPVRLL-ANRTVLASSLANWFGTMAG-FTCLYYIPIYFTTVLEFSSTENGLRFVPSVFLASL-SSVGAGFYMK-L---------TGKY-LWFAIVTSFL-SIVGVIHV-----ALI----------------------------TP--T------IPV--WDQYSLLILPYCGYSAMLT-VTLLALIAAVP-PE------QQASSTSIQYAFRSTGSTLGMSLASAF-F--QSVL-IRNLPTRLQD---------AAPPD----VSPKVLKKVIKN-ALSNGE------YVR----VAPEWAINPIKST-YESSCKAAFLFALVTVTLGFIS--ICFVKE---H---KL-----HTN-----------------------------------------------IARK----------------------------------------------------------------------------------------------- Yarrowia_lipolytica_CLIB122_yali0c16225g --------------------------------------------------------------------------------------------------------------------------MEKIGHKQKIWGERLEKLI--------CFHPWVRAIFFSKA----------------------------------------------------------------------------------------------------QIKHYPKRGSSTNAKERGWTRPIIIVGWIFVYLYAASKELAEKVHPTMAPLATSHFA------GLSL--LSSKAVVQSSIFIVTRPAFAKVCDH-IGRLEGWVIVVLCHLVGSVLFASAP-----NTGCYFAGIVFWEVATVGGHMMTELYASDTSTIN--TRIIFSSFIQSPNIWGP-YAAAPIVGAILDV--A------TWRW-GYGMFAIVIPVCSLGVLFLFSVM-------RVK----------------------------------------------------EFRLGARGDFY-----------------------------------TPGGF--------KR--------FL-----------LSF----DIVGLVMLCAGTILLFFPITLAEG------TDK-----WSR------PGFIAMLTIGSFL-L-AAFPL--WE-I-------------------Y-----GAQ-S----------P-LISWKLF-RNRAMICSCTILFFSSMSN-KLSVPYYTSWLLVVRGYSPKATTNINSAVTVANNAFGILFAAPYLL-W---------SGKP-KHMMVLGTCL-YLVGTGLT----YRFR----------------------------RQ--H------SGL--GILIISQVIEGIGRGTLYI-PCGTIAQAMFD-KH------KVAKVTAVYFTMGGIGQLVGDAILGAI-Y--KEVY-PQYIHKYAPD-------------------IPQKDLNLIINKIKKATK------------FPIGSPVRNEINRA-FDETMKHMLYGTFACAAMMFLA--VLCYPSVDFKEQGSVSVDEGEDI------------------------------------EPDDYRIEVRSQSDTELSESPSEKLEDPHFGSCKGQEEKLKK-------------------------------------------------------------------- Candida_guilliermondii_ATCC_6260_cagu_04513 ------------------------------------------------------------------------------------------------------------------------------MSQSAEHRLSQDDVEKQERLEHTDDVSSEDIEKVLPQ----------------------------------------------------------------------------------------------------SRGVAHIEAIRDTMLNVSSGKKVKVLLCASILVCAWVSVLDSSTTSSYEPFATSSFG------KHSM--IGTVTIAKTIIASVCRPIIAKIADL-TSRPHTYILVVTLYTVGYVISSAAQ-----DITAFSAGQVLAGIGFAGIDLINTLIVADLTPLK--WRGLLISFLATPYLINV-WFAGLISDAIVKR---------NWRW-GYGMFAIMIPVVIFPAIGVLLWL-------DRR----------AQ-------------------------------------KHKKLALTTSKLKQEIVPIAKKK--------------------------WVNIV--------WS--------AI-----------VEI----DLLGLLLLGFGFSLLLLPFSLASG------ASK----GWKN------PSLIAMMIVGGLL-L-IAYGV--YE-V-------------------Y-----YAP-I----------P-SMPRRVL-FNRTFLMSVCIDVVYLLAG-NIGDLYLSSYVYVVTNLSTRDWTYFNNTLTMGLCG-FGVVAGVIMR-I---------THRY-KYMQVTGLAI-KIIGYGLI------IR----------------------------PK--G------TVPNLASLVMNRLLIGCGGALSVV-ASQIAAQASVA-HQ------DLSLAMSLLSLWSNMGGAVGAAIATAV-W--QRDL-PGY----LND------------------FLPADSTDLAPT-LFGSFA------AIK--AYPESSPIRQAGIKS-YSYATHDFFIIALSLSFIPLIC--ACFQTN---F---FL-----GNT--------------------------------LNAVDVESEM-----AEKELAEADEPKTRLDKLAAFFNKKMV------------------------------------------------------------------------ Kluyveromyces_thermotolerans_CBS6340_klth0a07964g ----------------------------------------------------------------------------------------------------------------------MVDNHGEDPVSGVIHASNEVDGKNIVVEKLFSKNADMEQESPDTF----------------------------------------------------------------------------------------------------EVTESIVIRKAELMAKQYDSWFLKSLFLFTVFICSFAYGLDSIIRDIYMTYAMNAYE------THSL--LSTVNVISMVISAVGQIFFARLSDV-FGRLSLFIVSIVLYVVGTVIQSQAY-----DVQRYAAGSVFYNVGLVGAMFQVTLILSDCSTLK--WRLFYNFVPAWPAIITV-WISGNVVHVANPL--E------NWSW-GIAMWAFIFPVSCIPFIACILHM-------RWK----------VR-------------------------------------NSHEWRELQEEKSFYQTHG------------------------------LVQTF--------VQ--------LF-----------WRL----DVVGVILLSVFTGCICVPLTVAGG------VST----EWRS------GKVIAPFVLGFSL-I-PAFVY--WE-S-------------------R-----LAR-F----------P-LAPFLML-KDRGIWAPLWIYFLIAFIY-EMAAEYLYTILLVAANESDLSAIRITSLYSFVAAI-FSPIVGLLVA-R---------SSRL-KPYTVVGCSL-YFVTMGLF----YHYR----------------------------GG--N------DAG--KGVIGAMVVWGITSCLYDY-PISVSIQTVTS-HE------NLANVSALSSTIFRIGGAVGAAVSGAI-W--TQTL-YPKLLKALGD------------------------AGMAEAAFNSPLD------FIT--DYDWGTPVREATVEA-FQYVQKYEVLVGLIFVVPMFVM--TFFLRD---P---PL-----NEE----------------------------------------FGQNLNGEEYVKENDDPINDWIAERLSRFKKQD------------------------------------------------------------------------- 'Kluyveromyces waltii NCYC2644 klwa 001-snap.4' ----------------------------------------------------------------------------------------------------------------------MSDTPAVEPSPLLDQEVSQTNGKTIIVEKQCSKDVVHEHELPDKL----------------------------------------------------------------------------------------------------QVTKSIIIRKSELMAKQYDSWFSKSVFLLAAFICSFAYGLDSIIRDIYMTYAMDDYA------EHSL--LSTVNVVSLMISAVGQIFFAGLSDV-FGRLSLFVVAIIFYVVGTIIQSQAY-----DVGRYVAGSIFYNIGLVGAIFQVTIILSDCSSLK--WRLFYNFVPAWPAFVTV-WISGNVIHIANPS--E------NWSW-GIGMWGFIFPASCLPLIACMLHM-------RWK----------VK-------------------------------------NDREWKELQEEKSYFQTHG------------------------------VVQSL--------VQ--------LF-----------WKL----DVAGVLLLTACTGCILVPLTIAGG------VSA----QWRS------AKVIAPFVLGFAL-V-PVFLY--WE-S-------------------R-----IAL-V----------P-LAPFKML-KDRGIWAPLAIMFLICFIY-QMAAGYLYTVLLVAANESDLSATRITSLYSFVAAI-FSPILGVLVA-R---------STRL-KPYTLVGCSL-YFVTMGLF----YHYR----------------------------GG--E------DAG--KGIIGAMVVWGISSCLYDY-PISISMQTVTS-HE------MMATVTALNLTIFRIGGAVGAAVSGAI-W--TQAL-YPKLLKLLGD------------------------PEMAAKAYDEPLT------FIP--DYEWGTSVRDATVEA-YRYVQKYEVLVGLIFVAPMFVL--TFFLRD---P---SL-----TEE----------------------------------------YGQNLEDDEYVKENDDPINDWIMERFSRLKKQE------------------------------------------------------------------------- Candida_albicans_SC5314_caal_a_19.4779 ---------------------------------------------------------------------------------------------------------------MSGKKKENSFSNPDNAELQANAPSTPQNDSDSSVIVQPNIHNDIENQPTAEQ----------------------------------------------------------------------------------------------------KGFKESDAGDGTKKEDHYLHGVQLILCFLSLFLCLFLFALDQTIVVTILTTVGTKFD------AFSK--VGWLSSGFLLTMAVFIQFFGKLSII-IGRKWAMVIAIILFEAGSLMCALAN-----DMNVLIGGRVLAGIGGSGINSSVFVIGSEVVPIT--RRPLALSIFSITFAVAS--VVGPLIGGAFTS--K--V---TWRW-AF---YINLPIGGFATLVFLYAF-------RPP-----------R--------------------------------------------------------------------------------------PKVNV--------KQ--------QL-----------KQF----DYFGTFLLIAGSVILLLAITFGT-------SDF----PWDS------AAVISCFVLGPVL-L-IAFVV--WN-F-------------------G-----FSK-N----------Q-VISTEIV-KVPQIIASTLAISGIFSAF-IMFMIYGAIYFQVVKDASPLSAGLHLLPTIIAVVL-SSMLSGLLVQ-K---------FKFV-KPYNVISGIL-GPIGCGLI-----TLL----------------------------EV--D------SNF--SQQVGLLIILGVSAGLQMQ-PSFLSAQIKAP-KTPS----GMIMTTTFINFSRSILSAFGAVLADAV-Y--TTSL-KNIYSKAVKK--------------VTNPVILQDLQKFSLSQLTSSTA------LLK----TLHPETEHFVKTQ-IMNAIRNVFYMAIGFSAITFFA--AFFVTN---E---RL-----PKN--------------------------------VEKPEEQSNEKETKESDSSASDVSQPKETEEDEVRNEEPERI------------------------------------------------------------------------ 'Candida albicans WO-1 caal b 00508' --------------------------------------------------------------------------------------------------------------MSGKKKENSFSNTDNAELQANAPSTPQNDSDSSVIVQPNIHNDIENQPTAEQN-----------------------------------------------------------------------------------------------------GFKESDAGDGTKKEDHYLHGVQLILCFLSLFLCLFLFALDQTIVVTILTTVGTKFD------AFSK--VGWLSSGFLLTMAVFIQFFGKLSII-IGRKWAMVIAIILFEAGSLMCALAN-----DMNVLIGGRVLAGIGGSGINSSVFVIGSEVVPIT--RRPLALSIFSITFAVAS--VVGPLIGGAFTS--K--V---TWRW-AF---YINLPIGGFATLVFLYAF-------RPP-----------R--------------------------------------------------------------------------------------PKVNV--------KQ--------QL-----------KQF----DYFGTFLLIAGSVILLLAITFGT-------SDF----PWDS------AAVISCFVLGPVL-L-IAFVV--WN-F-------------------G-----FSK-N----------Q-VISTEIV-KVPQIIASTLAISGIFSAF-IMFMIYGAIYFQVVKDASPLSAGLHLLPTIIAVVL-SSMLSGLLVQ-K---------FKFV-KPYNVISGIL-GPIGCGLI-----TLL----------------------------EV--D------SNF--SQQVGLLIILGVSAGLQMQ-PSFLSAQIKAP-KTPS----GMIMTTTFINFSRSILSAFGAVLADAV-Y--TTSL-KNIYSKAVKK--------------VTNPVILQDLQKFSLSQLTSSTA------LLK----TLHPETEHFVKTQ-IMNAIRNVFYMAIGFSAITFFA--AFFVTN---E---RL-----PKN--------------------------------VEKPEEQSNEKETKESDSSASDVSQPKETEEDEVRNEEPERI------------------------------------------------------------------------ Candida_dubliniensis_CD36_cadu_08690 ---------------------------------------------------------------------------------------------------------------MSGIEREQPLSNPENAELDANAPSTPQNDFDSSVLVQPVVHHDIENQPGEEP----------------------------------------------------------------------------------------------------KGFKESDAGDGTKKEDHYLHGVQLILCFLSLFLCLFLFALDQTIIVTILTTVGTKFD------AFSK--VGWLSSGFLLTMAVFIQTFGKLSII-IGRKWAMVIAIILFEAGSLMCALAN-----DMNVLIGGRVLAGIGGSGINSSVFVIGSEVVPIT--KRPLALSIFSVTFAIAS--VVGPLIGGAFTS--K--V---TWRW-AF---YINLPIGGFAMLVFLYAF-------RPP-----------R--------------------------------------------------------------------------------------PKVNV--------KQ--------QL-----------KQF----DYFGTFLLISGCVILLLAITFGT-------SDF----PWDS------AAVISCFVLGPIL-L-IAFVI--WN-F-------------------W-----FSK-N----------Q-VISTEIV-KVPQIVASTLAISGIFSSF-IMVMIYGAIYFQVIKDASPLGAGLHLLPTIIAVVL-SSMFSGLLVQ-K---------FKFV-KPYNVLSGIL-GPIGCGLL-----TLL----------------------------QV--D------SNF--SQQVGLLIILGVSAGLQMQ-PSFLSAQIKAP-KSPS----GMIMTTTFLNFSRSILSAFGAVLADAV-Y--TTSL-KNIYTKAIKK---------VTNPV----ILQDLQKYDLSE-LTSSTS------LLK----SLHPETEHFVKLQ-IMDAIRNVFYMAIGFSVITFFA--AFFVTN---E---KL-----PKN--------------------------------VEKPEEQSTVKETKESDSSVSDASQTKEIEEDDAINEEPVRI------------------------------------------------------------------------ Kluyveromyces_thermotolerans_CBS6340_klth0b10450g --------------------------------------------------------------------------------------------------------------------MPEYQQGGPSLGSESTPNENYGKANVVQTEKEFSHDSKNEPELGDKL----------------------------------------------------------------------------------------------------QITKRIVIRKAELMANQYDGWLLKSMFLFSAFICAFSYGLDSIIRSIYMTYAMNDYQ------THSL--LSTVSVISLTISAVAQIFFAGLSDV-FGRLSMFIVAIMFYVVGTVIQSQAY-----DVQRYAAGSIFYYIGLVGSMFQVTLMLSDCSSLK--WRLLYNFVPAWPALVTV-WISGNVVHVANPE--K------NWSW-GIAMWAFIFPATCLPIIGCLLHM-------RWK----------LR-------------------------------------NNSEWKELQEEKTYFQTHG------------------------------LVQTL--------KQ--------LF-----------WKL----DVVGVLLFSVSTGCILIPLTIAGG------AST----HWRS------AKVIAPLVLGSLL-V-PFFIY--WE-S-------------------K-----LAL-V----------P-LAPFKML-KDRGIWAPLLITFLICFIY-MMAAGYLYTILLVAGNESSLSATRITSLYSFVAAV-FSPVVGIFVA-R---------FSRL-KPFAVFGCSL-YFVTMALF----YHFR----------------------------GG--T------DTG--KGVIGAMVVWGITSCFFNY-PINISMQTVTS-HE------NMATVTAFGLTIFRIGGAVGAAVSGAI-W--TQSL-YPRLLKALGD------------------------PTLALEAYNMPLS------FML--KHEWGTPARDAMIEA-YRYVQKYEVLVGLIFVAPMFLL--TFFLRD---P---PL-----TED-----------------------------------------YGQKLEDDEYVKHDDPITDWIAERFSSFKKHE------------------------------------------------------------------------- Kluyveromyces_thermotolerans_CBS6340_klth0d00110g --------------------------------------------------------------------------------------------------------------------MPEYQQGGPSLGSESTPNENYGKANVVQTEKEFSHDSKNEPELGDKL----------------------------------------------------------------------------------------------------QITKRIVIRKAELMANQYDGWLLKSMFLFSAFICAFSYGLDSIIRSIYMTYAMNDYQ------THSL--LSTVSVISLTISAVAQIFFAGLSDV-FGRLSMFIVAIMFYVVGTVIQSQAY-----DVQRYAAGSIFYYIGLVGSMFQVTLMLSDCSSLK--WRLLYNFVPAWPALVTV-WISGNVVHVANPE--K------NWSW-GIAMWAFIFPATCLPIIGCLLHM-------RWK----------LR-------------------------------------NNSEWKELQEEKTYFQTHG------------------------------LVQTL--------KQ--------LF-----------WKL----DVVGVLLFSVSTGCILIPLTIAGG------AST----HWRS------AKVIAPLVLGSLL-V-PFFIY--WE-S-------------------K-----LAL-V----------P-LAPFKML-KDRGIWAPLLITFLICFIY-MMAAGYLYTILLVAGNESSLSATRITSLYSFVAAV-FSPVVGIFVA-R---------FSRL-KPFAVFGCSL-YFVTMALF----YHFR----------------------------GG--T------DTG--KGVIGAMVVWGITSCFFNY-PINISMQTVTS-HE------NMATVTAFGLTIFRIGGAVGAAVSGAI-W--TQSL-YPRLLKALGD------------------------PTLALEAYNMPLS------FML--KHEWGTPARDAMIEA-YRYVQKYEVLVGLIFVAPMFLL--TFFLRD---P---PL-----TED-----------------------------------------YGQKLEDDEYVKHDDPITDWIAERFSSFKKHE------------------------------------------------------------------------- 'Saccharomyces castelli NRRL Y-12630 saca 663.28' --------------------------------------------------------------------------------------------------------------------------MSSQSSPEVHEKNHLSSKGNDIFTKEIESQNDDTQSSVPDF----------------------------------------------------------------------------------------------------AVKRSLVIKKTEIMSAVYDKWYHHVILLFSAFVCGYAYGLECNIRYIYTGYATSSYA------EHSL--LSTVNVINAVVSAASQIIYSRLSDF-FGRLTLFIIAIVLYVVGTIIQSQAY-----DVQRYAAGAIFYNAGYVGIILILLLILSDFSSLK--WRLFYQFAPTWPFIINT-WISGNVTSSANPL--V------HWSW-DVGMWAFIFPLACIPMIGCMIHM-------QWK----------AS-------------------------------------KTPEWHALRSEKSFYQANG------------------------------FYKTM--------TE--------LF-----------WKL----DIIGTLLFTACLGCILVPLTLAGG------TNS----KWNN------SRVIGPFVLGFVL-I-PILGV--WE-Y-------------------K-----WAR-D----------P-LIPYKLV-RDRGVWAALGISFLIDFIF-YMAADYLYTVMVVAVHESVKSATRISTLSSFVSTV-ASPFFALLMT-R---------CTRL-KPFIIFGCSL-WMLSMGLL----YNFR----------------------------GG--E------QSH--SGIIGALCV-GLGTVMFTY-PVTVSCQAATS-HE------HMATVTALTYTVYRIGSAVGSAISGCI-W--TQKL-YPEILKRLGG-----------------------NVSMATAAYASPYT------FIT--TYTWGTSEREAVVEA-YKYVQKLETVVALVFCAPLLMF--SLCLRD---A---KL-----TDK--------------------------------------VAHDGEIPEGEYTTKDEDPIADWFKACVGKFKKSKEVN---------------------------------------------------------------------- Saccharomyces_cerevisiae_EC1118_sace_b_1h21_0023g ----------------------------------------------------------------------------------------------------------------------MIEVPEDNRSSQTKRKNTEKNCNELMVDEKMDDDSSPRDEMKDKL----------------------------------------------------------------------------------------------------KGTKSLIIRKSELMAKKYDTWQLKAIFLFSAFICTFAYGLDSSIRGTYMTYAMNSYS------AHSL--ISTVSVIVLMISAVSQVIFGGLSDI-FGRLTLFLVSIVLYIVGTIIQSQAY-----DVQRYAAGAVFYYVGLVGVMLQVVLMLSDNSSLK--WRLFYTLIPSWPSIITT-WVSGSVVEAANPL--E------NWSW-NIAMWAFIFPLCCIPLILCMLHM-------RWK----------VR-------------------------------------NDVEWKELQDEKSYYQTHG------------------------------LVQML--------VQ--------LF-----------WKL----DVVGVLLFTAGVGCILVPLTLAGG------VST----NWRN------SKIIGPFVLGFVL-V-PGFIY--WE-S-------------------R-----LAL-V----------P-FAPFKLL-KDRGVWAPLGIMFFICFVY-QTAAGYLYTILVVAVDESASSATRIINLYSFVAAV-VAPFLGLIVT-R---------SSRL-KSYIIFGGSL-YFITMGLF----YRYR----------------------------SG--Q------DAD--GGIIAGMVIWGLSSCLFDY-PTIVSIQSVTS-HE------NMATVTALNYTVFRIGGAVAAAISGAI-W--TQSL-YPKLLHYMGD------------------------ADLATAAYGSPLT------FIL--SNPWGTPVRSAMVEA-YRHVQKYEVIVALVFSAPMFLL--TFCVRD---P---RL-----TED---------------------------------------FAQKLPDGEYVQTKEDDPINDWIAKRFAKALGRS------------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0e00132g --------------------------------------------------------------------------------------------------------------------MPEYQQENPSPNLGSTSSETNGKTVIVETEKQFTKEAESEHKLADKL----------------------------------------------------------------------------------------------------QITKRIVIRKSELMANQYDNWFLKSLFLFSAFICAFSYGLDSIIRSVYMTYAMNDYQ------THSL--LSTVSVISLTISAVAQIFFAGLSDV-FGRLSIFIVAIAFYVVGTIIQSQAY-----DVQRYAAGSIFYNIGLVGAMFQVTLMLSDSSSLK--WRLFYNFVPAWPALVTV-WISGNVIHLANPK--Q------NWSW-GIAMWAFIFPAACLPIIGCLLHM-------RWK----------LR-------------------------------------NDPEWKDLQEEKTYFQTHG------------------------------LVQTL--------KQ--------LF-----------WKL----DVVGVLLFSVSTGCILIPLTVAGG------AST----HWRS------AKVIAPIVLGSVL-V-PAFIY--WE-S-------------------K-----LAL-V----------P-LAPFKML-KDRGIWAPLLITFLICFIY-MMAAGYLYTILLVAGNESSLSATRITSLYSFVAAV-FSPVVGIFVA-R---------FSRL-KPFAVFGCSL-YFVTMALF----YHFR----------------------------GG--V------DTG--KGVIGAMVIWGITSCFFNY-PINISMQTVTS-HE------NMATVTALGLTIFRIGGAVGAAVSGAI-W--TQTL-YPRLLKALGD------------------------PTMATEAYNMPLS------FML--KHEWGTAARDAMVDS-YRYVQRYEVLVGLIFVAPMFVL--TFLLRD---P---PL-----TED-----------------------------------------YGQRLEDNEYVKHDDPITDWIAERFSRFKKHD------------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0f00110g --------------------------------------------------------------------------------------------------------------------MPEYQEEDPSLNLGSTSSETNGKTNVVETEEQFSKEADNEHELADKF----------------------------------------------------------------------------------------------------HVTKRIVIRKSELMANQYDNWVLKSLFLFSAFICSFSYGLDSIIRNIYMTYAMNNYE------THSL--LSTVNVISMTISAVAQIFFAGLSDV-FGRLSIFIVTIVFYVVGTIIQSQAY-----DVQRYAAGSIFYNIGLVGAMFQVTLMLSDSSSLK--WRLFYNFVPAWPAVVTV-WISGDVINVANPK--Q------NWSW-GIAMWAFIFPATCLPIIGCLLHM-------RWK----------LK-------------------------------------NDPEWKDLQEKKTYFQTHG------------------------------LVQTL--------KQ--------LF-----------WKL----DAVGVLLFSVSTGCILVPLTIAGG------VST----QWRS------AKIIAPIVLGSVL-V-LVFIY--WE-S-------------------K-----LAL-V----------P-LAPFKML-KDRGIWAPLLLMFLVCFVY-VMPADYLYTILLVAGNESSLSATRITSLYSFVTAV-LSAAAGILVT-R---------FPRL-KPFAFFGCAL-YFVTMALF----YCFR----------------------------GG--E------DTG--KGVIGAMVVWGVASCFFDY-PINISMQTVTS-HE------NMATVTALGLAIFRIGGAVGAAVSGAI-W--TQTL-YPRLLKTLGD------------------------PDMAIEAYDMPLS------FML--EHEWGTPVREAMVDS-YRYVQKYEVLVGLVFVAPMFLL--TFCLRD---P---PL-----TED-----------------------------------------YGQRLEDNEYVKHDDPITDWIAKHFSISKRHS------------------------------------------------------------------------- Zygosaccharomyces_rouxii_CBS_732_zyro0g21868g ------------------------------------------------------------------------------------------------------------MIIRRCPCQILQPRCLYQITFTIYTVTFSTDPSNSKLGQMSEDEVATIELNSLDK------------QNVQLTVQSSSENDSYKSGREH------------------------------------------------------------------SGALEGNKEDEEDLEIDLRDPKTFKWVLTSLWTNSALSALDGTIVSTTVNDVASRFQ------QASM--VTWVATAYLLTTTAAQPLYGKISDI-IGRRKCLLFGEIVFAVGVGLCIFSK-----SIPQLAIARGICGIGGSGTGAMTNIILSDMAPLS--ERGKYWGYGSMLGGVFQ--SLGGPLGGILLT--Y--F---GVSG-LF---IPQIPFCLATLYLSWKYV--------------------QD--------------------------------------------------------------------------------------YNQDT--------KG--------SW-----------KRI----DFGGSICLLVGISSFIFFFSADEN------PSISEHSGWS-------PYKKWSFAIFVLF-T-ILFLV--VE---------------------K-----YVALE----------N-IIPMEVL--KGTLGLLAFIQGLVSMIN-YTELFIVPLFLQLVWGISVSTSGAYIVCIVISYSV-GSLLSGALIK-KVAKPSRESTIYYS-GVSIFYMSLI-SMVGYYFLDRAVRYTK----------------------------PV--YGDTKVPESLN-FQLIFGITLLGLCQGSQGV-TIMLYNVAKVG-RK------GQASSTSVQFLFRSLGNVLSVSLAFNV-F--TNAL-RKT----LGK------------------VLAGKNDELFAL-LLKDNA------FLR--NKDMPTDDLDSILEA-FHKALVSSFVPCIWCLILSVIFSGVLWIAV---R---KQ-----YRS------VA------------------------------------------------------------------------------------------------------------------------------------------ Debaryomyces_hansenii_CBS767_deha2b16478g ---------------------------------------------------------------------------------------------------------------------------MVQDHDCKEIPPIGRDEE--------NTTKCTMDNEFKEV------------DEYEQSSSTKTHEPHVPL----------------------------------------------------------------------MRGVQLIENVKTAMDDSKRGNIVKAVYGTSILVCAWAASLDASTTNSLQPLATSSFG------AHSS--LATINIANGIIGAVSNPILAKFADL-ISRTFIYIISVFFYTVGYIIAASSQ-----TATAFIVGLGIATVGKTGVDFVNTLIVIDFTPLK--WRGFVTSILATPFIINC-WFAGLIVGDLRVA---------NWKW-GYGMFAIIIPVVLLPAIALMTYF-------DKT------------------------------------------------VTLADSFSAGKSKTKKEELYN-----------------------------IVSII--------KQ--------GL-----------IEV----DAFGLLLLGFGFALLLLPFSLAGS------ADN----GWRN------PSLIAMIIVGGLL-V-IAFFV--YE-I-------------------Y-----YAP-F----------P-AMPKRIL--NVTLVMSIIIDFFYYFAG-YIGLLYFSSYVFVVKDWNYTNWTYFNNTLTLALCI-FGVIAGILFR-V---------TRRY-KIWQLLGLAM-RIISYGIL------IL----------------------------GK--G------STIVTGALIAHPILAGGGGGLSVV-ASGVALQASVE-HS------QVALAIAMLSLWTRIGGSIGEAITSAI-W--NAKM-PAS----LRK------------------HLSSSVSDAQVAEFFGDIT------LLH--EYPIKSEIRQGAIAA-YQEVNYYFFCIALGLSFIPFIC--AFFQTN---Y---FL-----NDK--------------------------------QNAVDQDV-------HDEKDITKGAPKNWKDKFARCF----------------------------------------------------------------------------- Debaryomyces_hansenii_CBS767_deha2g17402g ---------------------------------------------------------------------------------------------------------------MNLSDKFGGRHIWRNREKKPSTINTENFASIRDFLSLTILQIRISRMARVED------------QTLNPNIIKDQSAGEAGIIVGD------------------------------------------------IAGETDGLINKSKDASYNSINGASNLDENYDESEYALPKAQLYTIVSGLFMASFLAALDTTVVTTLLTVIASDLN------AVSN--ISWIATAYLLSCSAFQPLFGKLSDI-FGRKILLVLCSMFFLIGCMVCVTD------SLMWLVAGRFITGIGGSGLTTLGTITMSDLIPLR--DRGLYQGLANVFFSLGA--ASGGILGGIVAD--T--L---GWKY-VF---ILQVPLGALVGIVIWWNL-------NLP----------KG-----------------------------------------SPGLGT---------------------------------------PGVDI--------KS--------KL-----------KRI----DFLGSFFLITSLMGIMIAASLGG-------REI----AYNS------CTFIGLIIVSLLL-L-GFFLY--TE-A-------------------Y-----ISA-E----------P-ILPIELI-TERTILSSSLTNWFYTMAI-FLNLYYLPVYFTSVMGFSATQNGLRLIPNFFGVSI-GSISAGIYMK-R---------TGRY-YKLAILMGIL-SIFGFANI-----IFI----------------------------NP--N------VSE--FRQFTFLLPSGFGYAAMLT-VTLLSLIAAVP-TK------FQACTTSIQYTFRSTGSTLGVSMASAI-F--QNIL-KGQ----LTT-----KVHDII-------PNIHKADKIIAK-ALESTN------YIK----EAPTIVQGALKES-YGLACKGAFVFSLATIVLGVAC--SLFMRE---H---VL-----HSS-----------------------------------------------INRG----------------------------------------------------------------------------------------------- Kluyveromyces_lactis_CLIB210_klla0c19272g --------------------------------------------------------------------------------------------------------------------------MAVKEEVVGKQAVSSHTVAANEFDLDEKQQPEVLNEYGLPD--------------------------------------------------------------------------------------------------KLRFTRSLVLRKTEILAQQYDTWYWKAVLLFSVFLCSYGYGLDGSVRSVYTTYATNSYS------THSL--LSTISIINLVIGASAQVFFARLSDV-FGRLTLLIVATVFYSVGTIIQSQAY-----DVQRYAAGAVFYNVGLVGVVLQVILILSDFSSLR--WRLFYTFVPSWPFIINM-WVSGNVVNAANPL--E------NWSW-SIGMWAFIFPLTCLPLVCCILHM-------RYR----------AS-------------------------------------KTEAWRHLQLEKTYYQSHG------------------------------LLQTL--------IQ--------LF-----------WKL----DVVGVLLLTVTLGCILVPLTLAGG------VSQ----KWNN------PHVIAPFVLGFVL-L-PIFVV--WE-S-------------------K-----WAL-D----------P-IAPFELL-KDRGVWSALTIQFLIYFVY-QMAVGYLYTILVIAVDESTTSATRITSVYSFTAAV-ASPFFALVVT-R---------SKRL-KPYIITGCSL-WMVAMGIL----YHFR----------------------------SG--K------DSD--KGIIGGLVLWGLTSTLFTY-PVTVSLQSITS-HE------NMASVTALNYTIYRIGGAVASAASGAI-W--TQLL-YKKLLKEMNG-----------------------DATLATAAYGSPFD------FIL--DYPWGTPMRDAMVES-YRYVQKYEVLVALIFTVPMFIL--SMFLRD---P---PL-----TDD--------------------------------------QAQENLKEGEYINTEHDDPILAWMDDKWTRITGGKKVE---------------------------------------------------------------------- Yarrowia_lipolytica_CLIB122_yali0f27709g ---------------------------------------------------------------------------------------------------------------------------------------------------MEKCKQVFHEVFLSTA----------------------------------------------------------------------------------------------------PVKHYPKKECNTNAKERGWTQKKIIIGWIFVYLYSSSKTIAQHLYPSLAPFATSHFS------GLAL--LSSQSVVESAVFVVTRPAAAKIADH-LGRLEGWCVVIIAHALGSILYAAAP-----NIGCYFAGTVFWEIGIVSGHLMMELYASDTSTTD--TRVLWSSFIQTPSIWAP-WISAPVLAGFLKV--T------TWRW-GYGAFAIILPVCSIGTVIMMAYM-------RIR----------------------------------------------------YERKAGGLGDFYSPGG------------------------------PLRFI-------------------------------KSF----DVVGLVTLCAGLILFFLPITLAAG------SER-----WKL------HSYIAMLTIGSFL-I-VFFTV--WE---------------------Y-----FPK-A----------P-FMPWRLF-KSRVMCCSAALVFLMSLAN-KLYVPYFITWLMVVKGQSPKAATNVSSVLVVSSNVFGMFFAAPYMW-W---------SGRP-KRVLVFGCCF-HLIGIGLT----YHYR----------------------------QP--S------SGL--AIMIVAQCFEGVGRGCIYI-PAATMAQAMFD-KH------KVAAVTALYFSSGGIGQVIGDAICGAI-Y--RELY-PRYIHKYAPD------------------IPHKDLNLIINK-IKKATK------------FPMGSLVRTEINHA-FNETMRHMLVGPFACVGAMVIV--SLMYPSIDLKSAARDGEVEGEDQ------------------MDEDDPMAIHGVPEGSGSESEHDQEEQFGEKDSREDTGSESEHANEKMSAERAAAGYINDNVMV---------------------------------------------------------------- Candida_glabrata_CBS138_cagl0b02079g ----------------------------------------------------------------------------------------------------------------------------------MDKDSVIADTR--------GDASSVSTGSVKEE-----------------------------------------------------------------------------------------------------------PVRTNAFGQRFPTGVELWAPLGSLVLCLFLAALDVMTVSTIIEEVSQKFG------DYSK--VGWLFTGYSLPNALLVLIWGRIATL-VGFKTSTLAAIVIFEVGSLVSALAN-----SMDMLIGGRVIAGIGGSGVQSLVFVISSTLVEER--NRGLIIAVMSSSFGIAS--VVGPFLGGAFTT--H--V---TWRW-CF---YINLPVGGLAFFLFLTFY-------NPEKWVVNKDTAEDE--------------------------------VVGNGRLGLLSILGGQAVRFVKSVGVQLAKLRYPGT------------------WRIIA--------RE--------LF-----------YRF----DIVEFVFMTLGSVLILLAFTFGG-------NKY----KWNS------GSTISMFVLGILF-T-LGAFV--YD-FFIYPKFEAVKT--------V-----PHY-Q----------P-LMSWNIC-KKPGVWLFNIAVFFVACAF-SIQTNYIIQYFQLVFNDTAWKAAIHLIATVVPVVI-TVVSSGIVNS-K---------TGYV-KPIAIFSGVT-GIIGAGLL-----TLL----------------------------DN--H------ASS--AKKIGLLILPGVTFGAIMQ-SSIIGVQILLD-KSSPTYRYDFIAVTTLNAFIKNIGQAYGAVLCDTV-F--SASA-INL----MKK-----RHVSLPGGY------ETSANNLIIA-RREYFD-------------GPTSAIGNIISDS-----IINVFYMALGMFAVVVVC--VVFVSN---K---KV-----DIR--------------------------------KPEDIKRQ-------QEEDPEKQDQNKDFKEDSE-------------------------------------------------------------------------------- Debaryomyces_hansenii_CBS767_deha2a03806g ------------------------------------------------------------------------------------------------------------------------------MDNKSTKESELDFSLRSKELNSREASDISLNKGNGNS----------------------------------------------------------------------------------------------------ENSLDEVKEHNKFVYLGAWNKKLLYVAYAVLIITAFVESFANNSTSSLDSYATSSFN------EHAL--IATVAVVYKITAICAYPILAKIADL-LGRAEGFTLSMILYSLAYVLYASCQ-----NVDTYVCAEIFFAIGRNGYRIFQLIFIADTSSLI--NRGILSQLPNAIGAIPS-LYAGSYVQDAFLEHST-------WRW-GYGSFAIILAAFCFPLGGIMFYL-------DRR----------AK-------------------------------------QNGQKKVYQILENIPKDAK------------------------------WYEKA--------YQ-------ILF-----------VEL----DLIGGVLLLCGFALFFVPFTVTGK-----SSSY----KWHE------PKLIVMLVIGFVI-F-CCFLV--WN-T-------------------K-----FAK-K----------P-FVPTQAL-KSKTVVIIVVLVALDLCEN-SSFATYFKTVLQVAGYYSAGAATRIDNSKKVTVDI-FNVFGGLLMK-Y---------TKRS-KIYALIGIPM-LVLGHGLL--VWFMRR----------------------------GDGEM------ASY--ALLVMAEVFIGFGRGMYQC-ALQVTIQAIAG-IE------GIAMSTAFFLAFQSIGSLIGSAISGGI-W--NTVV-LSKLNLYLPE-------------------DDKDLAKKIYKSITVAMS------------YEKGSDIRDGINRA-YAETIQIIGWTGLGIIAPMLIL--MFFIKE---V---KL-----SEA--------------------------------KDIYSVSISEEEIKIKEEKEIEIKEEKESLKKNTSRGQ---------------------------------------------------------------------------- Kluyveromyces_lactis_CLIB210_klla0c00220g ------------------------------------------------------------------------------------------------------------------------------MHNNPVLKMENDQIEDGVGHRKEGAAEKINEMDEDSK------------KGVQFSGVCDGM----------------------------------------------------------------------------KQTKSLVIRKTEIMASQYNTWYSQVLFLSCAFLCAYGYSLDSSIRYVYMTYATNSYN------THSL--LSTISIINMMISAVAQLFFAGLSDV-FGRLRLMIVAILFYVVGTVIQSQAY-----DIQRYAAGSVFYNIGVVGVMLQVSLFLADNSSLK--WRLLYSFVPAWPAIINM-WVSGNIVKAANPL--V------NWSW-NIAMWAFILPLSCVPLLCCVVHM-------RWK----------AS-------------------------------------KTPEWQELESELTFYQKHG------------------------------FVHTI--------VE--------VF-----------WKV----DIVGLLLLTASMGCILVPLTIAGG------ISE----QWNN------GKIIGPLVLGVFL-V-PLTIY--WE-S-------------------N-----WAK-V----------P-FAPFLLL-KDRGIWAPMSIMFLVCFIY-QMAAGYLYTILLVSMNQTELSATRIMNLYSFVAGI-YSPIFGFVVA-R---------TGRL-KSFMLVGCCL-YFLVMGLF----YRYR----------------------------GG--L------GAE--SGIIGAMVVWGIASCMYTY-PVTTSAQSVTS-HE------NMATVTAMLLTIFRIGGAVGASVSGAI-W--TNLL-YPKLLQNLGD------------------------VELASAAYTAPLT------FIV--SHPWNTEVRTAMIDA-YRHVQKYEVLVGLIFVAPMLVL--TFCLRD---P---EL-----TDD---------------------------------------YGQKLAEGQCVQTEGEDPIAEWFSDRFKKLKRRV------------------------------------------------------------------------- Kluyveromyces_thermotolerans_CBS6340_klth0g09504g ----------------------------------------------------------------------------------------------------------------------------MSLKMLGFNKGPEEKEA--------GDAMERSRRADEAL----------------------------------------------------------------------------------------------------RRQKDVGVKNIEVYAAQYDHVAYRVALFFSLFLIAYAYRLDGLVRSKLEAYATDSYG------NHSL--LSTVNCIKTVMAAGGMVAYARASDM-FGRMEMLAISIVLVVVGTIVECQSD-----TVSKFATGACLYQLGKAGLALILQVIAVDFSNLN--WRMVALYVPALPTIINT-WVSGDVISAIGSD----------WEW-GIGMWAFIIPLSCIPLFCCLVHM-------RYL----------AH-------------------------------------KHAPEQLGKQRQLYSMAS-------------------------------WSEYL--------IE-------VFF-----------WRL----DSVGLILVVGALGCVLVPFTLAGG------LSD----KWRT------AQIIVPEVIGWCVAL-PLFVL--WE-A-------------------K-----FAR-F----------P-LTPRSVL-KDRGVIAALVIAFHIHFCV-YMQADYMYTVLVIAVHESVKAAQRITTLFNFVSII-TGTLLGFVIV-Y---------VKRT-KKFILFGVCV-WFVAFGLL----VHFR----------------------------GD--E------SSH--SGIIGALCLLGFGGGFFNY-SAQVSMQASTAAHQ------DLAVVTSLYLACYNIGSAFASAISGAI-W--TNVL-PKELNKRITE------------------------KQVATLAYSSPFK------FII--KYKWGTPQRVAVVHA-YQKVQRILCIVPLCFCVTLLIA--AFLLRD---K---KL-----SEV-----------------------------VALGELEHGHSESASSTGDAGASHELSSTENELHNESEKSSNTRVQNNPVTA----------------------------------------------------------------- Candida_parapsilosis_CDC_317_capa_05437 --------------------------------------------------------------------------------------------------------------------MPEVESEHKKTSSGKAQSPMSSEPSTHTSERANSEIEDAVSIKKPKQ----------------------------------------------------------------------------------------------------QKYTEADAGDGTKAHEQYLTGVPLFLTIISCVVTLFIAALDQTIVSTILTTVGDDFN------SFEK--VGWLTSGFMLPMACLIPSYGKISIA-FGRKATLIAGIIVFEIGSLISALSN-----SMSLLIGGRVIQGIGGGAIQSMVMVILTESVPIS--RRSLVFASVSVVWSTSS--VLGPIIGGALEK--I------TWRW-CF---YINLPIGGVSLLVLIFGF-------NPP-----------K--------------------------------------------------------------------------------------PKGNI--------RE--------KL-----------STI----DYIGTFFLTSGLVLVLLGLTFGG-------VDF----PWRS------AAVICLFTIGGVL-L-IIFCI--WN-F-------------------R-----YSS-H----------P-IILAEFV-KSFTTMTALISAMFNFGFF-ISNLTYLAVYFQVVFNASSLQSGIDLLPLVVSVTI-ASLANSMFIN-M---------TKNV-KITMIVSGIL-SPLGSGLL-----LLL----------------------------DK--H------SSV--GKRIGILLVSGIAIGLQFQ-SSTLSAQLVAP-KDIPG---ALILVTVLLNFGRELASTISVTIAQLL-F--QVTG-TRY----LED-----LQRDMSSSV----DGYAQFANISAKSLISNPR------LVR----NFPNEVREMVLDQ-YMKALKNVFYFGLALAVVCFIA--SLFTTG---K---KI-----PKT--------------------------------KDIKTADSEDDQEQMKKAKVSDEADQLQTEEPTAESLSSHQEQHPTMREVSK-------------------------------------------------------------- Kluyveromyces_polysporus_DSM_70294_klpo_513.33 ----------------------------------------------------------------------------------------------------------------------------MSDIKYQENLKTKTFDE--------DAKIESISVHTDSE----------------------------------------------------------------------------------------------------NIVTNIAAHNARIYVKYYSTPLRVTILYFSLFLLAYAYNLHKDVRGTYQTLATSSYS------KHSL--LATVQCINQVISAAGQIWYARASDI-FGRTPILILSILFYFIGTLIESQAT-----DISKYAAGSCIYALGYAGSVLVTQVLVSDYSTLK--WRLVSSTVLFLPNIINT-WVGGNITEDVGNR----------WQW-GFGMWAFIFPLASIPLLCCLAHM-------KYL----------AI-------------------------------------KNKEDVKLTISKPRSIS--------------------------------WARHL--------YD-------IFF-----------WKL----DMLGLILLVAFFALILVPLTLAKG------LHE----GWGS------AKFIVPEVLGWALAL-PLFLT--WE-L-------------------K-----FAS-N----------P-ITPLDLI-KDRGIYGGIGVSLFLEFVY-DIGSTYLYTVLVVAVNESTKSATRITSLFTFVSVL-TAFFLGFVVV-K---------VRRT-KEFIIFGIAM-WYIAYGLF----EHYR----------------------------GG--A------ESH--AGIIAAVCVHGFGNGFIKF-PVRVSTQASAKTHD------RLAIATSLYLAAGDIGMAFGSATAGAM-W--TNIL-PAQIDMVIQN------------------------STLAKIAYESPIK------FIR--THKWDSPERQALVVA-YRYIQRLLMIVALCLIIPLLLS--SFFLRNRALTDTVAFEQTDIPKE--------------------------------SDSSDLENSKIDNLEEDSEEDSSNGESKPKKKTISRFFHNIFHN---------------------------------------------------------------------- 'Lodderomyces elongisporus NRRL YB-4239 loel 05322' ------------------------------------------------------------------------------------------------------------------------MSNPRNNSTTSGSDTIVENYDNNHSYNNHGDDEKHIKFEEAHHITVCERTGPHTPSESIYTVVGEHSLQHKELSEKLDNA---------------------------------------------------------------QIQSNELATKLGDAHFNQLPAHQIIIILLTLSLANFVSFADQTGITVGLSEIGRDLN------AETS--INWAGSASLLANTVCQVLFGRLSDI-FGRKKVIMTCLMILCVGDIACSVAR-----NGIEFFVFRALAGIGNGGVSSLSMVILSDIVSLK--DRGKYQGILGSSVGIGN--AVGPFIMAGFIK--Q--S---SWRS-YY---YFLAPLAFCVNIVLFFSL-------KSN----------KK--------------------------------------------------------------------------------------LNDVI------SRKE--------KF-----------KSI----DYFGILTATISLTLILVPLNGGG-------STY----PWNS------PTVIALFTVGGVF-F-LIFFA--IE-V-------------------K-----VAK-L----------P-MIPMRLF-KNLSLCLIYTATFCFGAAY-FSFTYYLPYYFSIVKGKDEIHTAIFVLPLVLCQAG-MSVVAGQIIT-F---------TGRY-FYVVISGYAL-WLTGCCLL-----LLW--------------------------------T------ETLPDGINILILLIMGCGVGFSFQ-PSMVAVQANCK-KA------ERAVAISTRNVLRSLGGCVGIAVGSTI-V--SNSV-LAS----LKT------------------DKAKSALSQQTIEYIRGHI------YDKVDVSVLTAAQTQEIRSI-YTDALKNYYYFLIPLMAIALIT--NLFVKDNGLR---SL-----DEK----------------------------------------------PESAKRQDLESSASSMTLKP-------------------------------------------------------------------------------- Yarrowia_lipolytica_CLIB122_yali0b19250g ---------------------------------------------------------------------------------------------------------------------------------------------MPEWKAIWKTIFNPEVTIAQDA----------------------------------------------------------------------------------------------------PDLDGPGGVKEIENVTSIWSKKGLWIAWGSMLLLAVAIALDAQTVFVYSTFATSSFN------QMSL--LSALGVVQSVMYIATRPVMAKIADV-LGRFEGLLLSIVILTVGFIMLAASP-----NIGTYFAAQIFYVFGQVGIQFMQQVFAADTSDLK--NRTFFVILPNLCYLFVP-WCAAPITNAVLKH--T------TWQW-GYGMWCIIVPVVSIPVLTTMFVN-------KLK----------AR-------------------------------------RLGLQAGL-----------------------------------------AVKNF--------KK--------TV-----------QHF----DFIGLILLTAGLVTLFLAATLVK-------TSA----DWNK------PHVLGMIIVGPIC-L-TLFPI--WE-I-------------------------FPK-Y----------P-FLPFRVL-RNRVLLTCCFYIALYFLAF-YLYQPYYYSWLMVCKNLSVTAATNTSVTTTVSSTA-GGLFTAIAIR-Y---------TKRI-KPFIVVGSCI-YLLGLGLS----YNYR----------------------------QP--Y------HSL--AQFIVSQAVEGVGAGMLGS-PTQVMVQAVVS-HN------QVAAATAVYLSSTSIGNVVGDAISGAM-Y--RQMY-PKRLREYASF------------------LNETEIDTIINN-INEPLK------------YTWGSPERTQIVTA-FNKVYRHMLYGPLIVAGAMIVI--SLTLPN---INLDEI-----EQQVKGVVFGKSQKANQADENPVGDFGGNPVGGFGAEPVAAFAPEYNGQHDIEKNAYEQKLELDTESDKKSETRV-------------------------------------------------------------------------- Candida_albicans_SC5314_caal_a_19.1942 -------------------------------------------------------------------------------------------------------------------MGQRMPSPPSSHITNPWKTPEQTASSSHGHDEVISPETNTYSPDFSNYTRNSSSYRHVDKKSASPPTTTFDNQTFQESNHDDTNN---------------------------------------------------------------QQYVEADAGDGTKAHEQYLTGFPLFLTISSCIISLFLVALDQTIVSTILTTVGNKFN------AFEK--IGWLTSGFMLPMACLVPSYGNISIA-FGRKWTLVAGIIIFEIGSLISAISN-----SMSLLIGGRVIQGIGGGSIQAIVMVILTEVVPMN--RRSLVFASISVVYSTSS--VLGPIIGGALEK--I------TWRW-CF---YINLPLGGAALVILMLGF-------HPP-----------K--------------------------------------------------------------------------------------PQGNV--------RE--------KL-----------SKI----DFIGFVLLTSGLVLVLLALTFGG-------VNY----PWNS------GSIIALFTVGGGM-L-LLFVI--WN-F-------------------K-----YSA-N----------P-IILTELI-VDWRVLSACLSGMFNFAFF-ISNLTYLAVYFQVIFNASSLQSGIDLLPMVISVTL-ASLANSFFID-F---------TKNV-KITMLVSGVL-SPLGCGLF-----LLL----------------------------DE--D------SSI--GIRIGLLIISGVSIGLQFQ-SSLLSAQLAVS-KDIPG---ATILVTVFSDFVKNFASTISVTLAQLL-Y--QTTG-QKYITDMMGN---------LPEDS----QDYKDLNKYTAAKFISNPE------IVQ----DLPDSAKSLVLSQ-LMKALKNVFYLGLGLAILCFIT--SLFTTN---K---KI-----PKN-----------------------------------------------VEIKKNDDEESNKNE------------------------------------------------------------------------------------ 'Candida albicans WO-1 caal b 04515' -------------------------------------------------------------------------------------------------------------------MGQRMPSPPSSHITNPWKTPEQTTSSSHGHDEVISPETNTYSPDFSNYTRNSSSYRHVDKKSASPPTTTFDNQTFQESNHDDTNN---------------------------------------------------------------QQYVEADAGDGTKAHEQYLTGFPLFLTISSCIISLFLVALDQTIVSTILTTVGNKFN------AFEK--IGWLTSGFMLPMACLVPSYGNISIA-FGRKWTLVAGIIIFEIGSLISAISN-----SMSLLIGGRVIQGIGGGSIQAIVMVILTEVVPMN--RRSLVFASISVVYSTSS--VLGPIIGGALEK--I------TWRW-CF---YINLPLGGAALVILMLGF-------HPP-----------K--------------------------------------------------------------------------------------PQGNV--------RE--------KL-----------SKI----DFIGFVLLTSGLVLVLLALTFGG-------VNY----PWNS------GSIIALFTVGGGM-L-LLFVI--WN-F-------------------K-----YSA-N----------P-IILTELI-VDWRVLSACLSGMFNFAFF-ISNLTYLAVYFQVIFNASSLQSGIDLLPMVISVTL-ASLANSFFID-F---------TKNV-KITMLVSGVL-SPLGCGLF-----LLL----------------------------NE--N------SSI--GIRIGLLIISGVSIGLQFQ-SSLLSAQLAVS-KDIPG---ATILVTVFSDFVKNFASTISVTLAQLL-Y--QTTG-QKYITDMMGN---------LPEDS----QDYKDLNKYTAAKFISNPE------IVQ----DLPDSAKSLVLSQ-LMKALKNVFYLGLGLAILCFIT--SLFTTN---K---KI-----PKN-----------------------------------------------VEIKKNDDEESNKNE------------------------------------------------------------------------------------ Candida_dubliniensis_CD36_cadu_51060 -----------------------------------------------------------------------------------------------------------MGQRMLCSSSSHTTKLWKTPEQTASLSHDQDEITSPETNTYSPDFSSYADNGITNRHVDKEICSYPPFENQTLSESNHEEANS-------------------------------------------------------------------------QQYIEADAGDGTKAHEQYLTGFPLFLTISSCIISLFLVALDQTIVSTILTTVGNKFN------AFEK--IGWLTSGFMLPMACLVPSYGNISIA-FGRKWTLVAGIIIFEIGSLISGISN-----SMSLLIGGRVIQGIGGGSIQAIVMVILTEVVPMN--RRSLVFASISVVYSTSS--VLGPIIGGALEK--I------TWRW-CF---YINLPLGGAALAILMFGF-------HPP-----------R--------------------------------------------------------------------------------------PQGNI--------RE--------KL-----------SKI----DFIGFVLLTSGLVLVLLALTFGG-------TNY----SWNS------GSIIALFTVGGGM-L-LLFIV--WN-F-------------------R-----YSA-N----------P-IILTALI-VDWRVLSACLSGMFNFAFF-ISNLTYLAVYFQVIFNAGSLQSGIDLLPMVISVTL-ASLANSFFID-F---------TKNV-KITMLASGVL-SPLGCGLF-----LLL----------------------------NE--D------SSI--GIRIGLLIISGISIGLQFQ-SSLLSAQLAVS-KDIPG---ATILVTVFSDFVKNFASTISVTLAQLI-Y--QTTG-QKYVSEMMTN---------LSEDS----QDYKDLNKYTTAKFISNPE------VVQ----ELPNSAKSLVLRQ-LMKALKNVFYLGLGLAILCFIT--SLFTTN---K---RI-----PKN-----------------------------------------------VEIKKNEDQESNKNEPN---------------------------------------------------------------------------------- Kluyveromyces_thermotolerans_CBS6340_klth0b00110g -------------------------------------------------------------------------------------------------------------------------MIRVASTIKILRSINTNHKMITGGIKAYELKEEKFDVTEHDI------------ESVADSNKSSK-----------------------------------------------------------------------------LGSGFLKVKEMEIMSSTCSGKSARAALLASAFLCGFGYYLDYITRSVYTGYATSSYN------EHAL--LSTIQVINSVISIAAQIIFAQLSDI-FGRLQLFLVGTVLYIVGTIIQCEAR-----DIRTYAVGAAFYNSGYVGVSILLIIVLSDLSPSK--WRLLFQFATSWPCIIIC-WISGDIVQSANPA--K------NWRF-DIGMWAFLFPISALPFIIFLLYF-------TRQ----------AS-------------------------------------KTAEWKEIQGDNKEPSVR-------------------------------IVYWI--------KS--------IY-----------SNI----DVVGTSLVTVSLGCILVPLTLAGG------ISD----DWNK------PGIIATIVVGFVS-F-MFFLA--WD-I-------------------K-----FAK-N----------A-VLPFKLL-KDRGVWASLAAALLEKLIY-ATISDYLYPVLLVSVNESSKSATRILWLPTFVACT-GSIFFGLLVV-R---------TKRL-KIYSIIGVCL-WILSIGLF----YHYR----------------------------GG--A------SSH--SGIIGASVVLGTGSAIFTQ-SLIVNLQTMTS-HK------NMASITGLYFMFAQIGSASGASISGAI-W--TQTM-YKQLYKRLED------------------------SSLAATAFSSPYE------FIE--LYPWGTPERTQMIYA-YREVQKKTMLVSLVLTGPLFLL--ILFTKD---R---KL-----GDN---------------------------------------------VTAETTQSDEDPMLTWILKRFNKIKAGWKQKSQS------------------------------------------------------------------- Pichia_stipitis_CBS_6054_pist_igi16603948 ----------------------------------------------------------------------------------------------------------------------MSERQSIPVLASTIESSRRSPTDLHSQELSPQDLNSCSPKTTRKS----------------------------------------------------------------------------------------------------GKYYESNAGDGTKNSEQYIKGIKLAVTLVSCVACLFLVALDQTIIATILTQVGDKFQ------EFEK--VGWLTTGFFLPIACLSPSYGKIGIA-FGRKYTLLVGVIVFEIGSLISALAN-----SMGMLISGRVVSGLGGGCVQAMVVLILTESVPIN--LRPLSYTLLGVTFSVAS--VLGPFVGGALAT--H--V---SWRW-CF---YINLPIGAMASLLLMLGF-------HPP-----------K--------------------------------------------------------------------------------------PHGSI--------RQ--------KM-----------ARI----DYLGTFLLTTGLVLVLLALTFGG-------ISN----PWNS------ALVISFFVVGGVL-C-IVFNI--WN-F-------------------G-----FST-H----------P-MIIKEVI-MVPQAAAACINACFNFGFF-IPLMTYLAVYFQVIFGHSAWKSGVDLIPMIISVTF-SSISNGVFIR-F---------SRNV-KLTMVISGVL-GPVGTGLL-----LLL----------------------------NK--H------SSA--KDRIGLLIVSGVSIGLSFQ-SSMLAAQLKAP-PDIEG---SLISVTIFVNFVKNLGAAVSVTIAQLI-F--QTTG-QRY----LND-----LIRSLPPDS----SEYRELIRYPPKQVISSPE------IIK----SFSESTRQLVLDQ-FMKCIKNVFYLAFALSVIAMIA--SFFTTN---K---RI-----PKH--------------------------------SDIERDDDGDDEEANEIQNEDTESDQLNENNKISPDSSNGESSSGSETKQEFTA------------------------------------------------------------ 'Saccharomyces bayanus 623-6C saba a 676.52' ---------------------------------------------------------------------------------------------------------------------MDPATANRALPEEFTEVVVPEILEKEVGTTTAAGPALTTSSPAPSY----------------------------------------------------------------------------------------------------IELIDPGVRNIEIYAEQYSRPLYRAGLFFSIFLIAYAYGLDGGIRYTFQAYATSSYS------QHSL--LSTVNCIKTVIAAVGQIFFARLSDI-FGRFSILVISVIFYSVGTIIESQAV-----TITRFAVGGCFYQLGLTGVILILEVIASDFSNLN--WRLLALFVPALPFIVNT-WISGDVTSAIGTN----------WKW-GIGMWAFILPLACIPLGLCMLHM-------RYL----------AR-------------------------------------KHAKDKLRPEFETLNNLD-------------------------------WKSFS--------ID-------IVF-----------WKL----DLIGLLLVTAFFGCVLVPFTLAGG------LKE----EWKA------AHIIVPEVIGWVVAL-PLYMV--WE-V-------------------K-----YSR-H----------P-LTPWDLI-KDRGVLFALFIAFFINFNW-YMQGDYMYTVLVVAVHESIKSATRITALYSFVSVI-VGTILGFILI-K---------VRRT-KPFILFGISC-WIVSFGLL----VHYR----------------------------GD--S------GAH--AGIIGSLCLLGFGAGSFTY-VTQASIQASAGTHA------RMAIVTSLYLATYNIGSAFGSSVSGAV-W--TNIL-PKEISKRISD------------------------PTLAAEAYGSPFT------FIT--TYTWGTPERIALVMS-YRYVQKILCIIGLVFCFPLLGC--ACMLRN---H---KL-----TDS--------------------------------IALEGNDHLESKNDNEIVEKEETSLRTRFLAQFTSKEKKN-------------------------------------------------------------------------- Saccharomyces_bayanus_MCYC_623_saba_b_c280_5966 ---------------------------------------------------------------------------------------------------------------------MDPATANRALPEEFTEVVVPEILEKEVGTTTAAGPALTTSSPAPSY----------------------------------------------------------------------------------------------------IELIDPGVRNIEIYAEQYSRPLYRAGLFFSIFLIAYAYGLDGGIRYTFQAYATSSYS------QHSL--LSTVNCIKTVIAAVGQIFFARLSDI-FGRFSILVISVIFYSVGTIIESQAV-----TITRFAVGGCFYQLGLTGVILILEVIASDFSNLN--WRLLALFVPALPFIVNT-WISGDVTSAIGTN----------WKW-GIGMWAFILPLACIPLGLCMLHM-------RYL----------AR-------------------------------------KHAKDKLRPEFETLNNLD-------------------------------WKSFS--------ID-------IVF-----------WKL----DLIGLLLVTAFFGCVLVPFTLAGG------LKE----EWKA------AHIIVPEVIGWVVAL-PLYMV--WE-V-------------------K-----YSR-H----------P-LTPWDLI-KDRGVLFALFIAFFINFNW-YMQGDYMYTVLVVAVHESIKSATRITALYSFVSVI-VGTILGFILI-K---------VRRT-KPFILFGISC-WIVSFGLL----VHYR----------------------------GD--S------GAH--AGIIGSLCLLGFGAGSFTY-VTQASIQASAGTHA------RMAIVTSLYLATYNIGSAFGSSVSGAV-W--TNIL-PKEISKRISD------------------------PTLAAEAYGSPFT------FIT--TYTWGTPERIALVMS-YRYVQKILCIIGLVFCFPLLGC--ACMLRN---H---KL-----TDS--------------------------------IALEGNDHLESKNDNEIVEKEETSLRTRFLAQFTSKEKKN-------------------------------------------------------------------------- Saccharomyces_cerevisiae_S288C_sace0h00308g -----------------------------------------------------------------------------------------------------------------MESVHSRDPVKEEKKHVFMGMEHELNPETHNDSNSDSYGLPQLSEKYNAL----------------------------------------------------------------------------------------------------RQNRSLIIQQTEIIGSAYNKWYLQAILLLSAFICGYGYGLDGNIRYIYTGYATSSYS------EHSL--LSTINVINAVVSAASQIIYARLSDV-FGRLYLFISAVILYVVGTIIQSQAY-----DVQRYAAGAIFYNAGYVGVILILLIILSDFSSLK--WRLLYQFVPTWPFIINT-WIAGNITSRANPV--V------NWSW-DVGMWAFIFPLSCVPIVLCMLHM-------QWR----------AR-------------------------------------KTPEWHALKGQKSYYQEHG------------------------------FIKIL--------KQ--------LF-----------WML----DVVGVLLMGCSLGCILVPLTLAGG------VKT----TWND------SRLIGPFVLGFVL-I-PILWI--WE-Y-------------------R-----FAR-D----------P-ILPYRLV-KDRAVWSSMGISFLIDFIY-YMAADYLYTVMIVAVNESVKSATRIATLSSFVSTV-ASPFFALLVT-R---------CTRL-KPFIMFGCAL-WMVAMGLL----YHFR----------------------------GG--S------QSH--SGIIGALCVWGVGTTLFTY-PVTVSVQSAVS-HE------NMATVTALNYTLYRIGSAVGSAVSGAI-W--TQTL-YKQILKRMGD------------------------VALATTAYESPYT------FIE--TYTWGTPQRNALMNA-YKYVQRLETIVALVFCVPLIAF--SLCLRD---P---KL-----TDT--------------------------------------VAVEYIEDGEYVDTKDNDPILDWFEKLPSKFTFKRE------------------------------------------------------------------------ Saccharomyces_cerevisiae_EC1118_sace_b_1h21_0100g -----------------------------------------------------------------------------------------------------------------MESVHSRNPVKEEKKHVFMGMEHELNPETHNDSNSDSYGLPQLSEKYNAL----------------------------------------------------------------------------------------------------RQNRSLIIQQTEIIGSAYNKWYLQAILLLSAFICGYGYGLDGNIRYIYTGYATSSYS------EHSL--LSTINVINAVVSAASQIIYARLSDV-FGRLYLFISAVILYVVGTIIQSQAY-----DVQRYAAGAIFYNAGYVGVILILLIILSDFSSLK--WRLLYQFVPTWPFIINT-WIAGNITSRANPV--V------NWSW-DVGMWAFIFPLSCVPIVLCMLHM-------QWR----------AR-------------------------------------KTPEWHALKGQKSYYQEHG------------------------------FIKIL--------KQ--------LF-----------WML----DVVGVLLMGCSLGCILVPLTLAGG------VKT----TWND------SRLIGPFVLGFVL-I-PILWI--WE-Y-------------------R-----FAR-D----------P-ILPYKLV-KDRAVWSSMGISFLIDFIY-YMAADYLYTVMIVAVNESVKSATRIATLSSFVSTV-ASPFFALLVT-R---------CTRL-KPFIMFGCAL-WMVAMGLL----YHFR----------------------------GG--N------QSH--SGIIGALCVWGVGTTLFTY-PVTVSVQSAVS-HE------NMATVTALNYTLYRIGSAVGSAVSGAI-W--TQTL-YKQILKRMGD------------------------VALATTAYESPYT------FIE--TYTWGTPQRNALMNA-YKYVQRLETIVALVFCVPLIAF--SLCLRD---P---KL-----TDT--------------------------------------VAVEYIEDGEYVDTKDNDPILDWFEKLPSKFTSKRE------------------------------------------------------------------------ Saccharomyces_cerevisiae_JAY291_sace_c_03075 -----------------------------------------------------------------------------------------------------------------MESVHSRNPVKEEKKHVFMGMEHELNPETHNDSNSDSYGLPQLSEKYNAL----------------------------------------------------------------------------------------------------RQNRSLIIQQTEIIGSAYNKWYLQAILLLSAFICGYGYGLDGNIRYIYTGYATSSYS------EHSL--LSTINVINAVVSAASQIIYARLSDV-FGRLYLFISAVILYVVGTIIQSQAY-----DVQRYAAGAIFYNAGYVGVILILLIILSDFSSLK--WRLLYQFVPTWPFIINT-WIAGNITSRANPV--V------NWSW-DVGMWAFIFPLSCVPIVLCMLHM-------QWR----------AR-------------------------------------KTPEWHALKGQKSYYQEHG------------------------------FIKIL--------KQ--------LF-----------WML----DVVGVLLMGCSLGCILVPLTLAGG------VKT----TWND------SRLIGPFVLGFVL-I-PILWI--WE-Y-------------------R-----FAR-D----------P-ILPYKLV-KDRAVWSSMGISFLIDFIY-YMAADYLYTVMIVAVNESVKSATRIATLSSFVSTV-ASPFFALLVT-R---------CTRL-KPFIMFGCAL-WMVAMGLL----YHFR----------------------------GG--S------QSH--SGIIGALCVWGVGTTLFTY-PVTVSVQSAVS-HE------NMATVTALNYTLYRIGSAVGSAVSGAI-W--TQTL-YKQILKRMGD------------------------VALATTAYESPYT------FIE--TYTWGTPQRNALMNA-YKYVQRLETIVALVFCVPLIAF--SLCLRD---P---KL-----TDT--------------------------------------VAVEYIEDGEYVDTKDNDPILDWFEKLPSKFTSKRE------------------------------------------------------------------------ 'Saccharomyces cerevisiae RM11-1A sace d 04665' -----------------------------------------------------------------------------------------------------------------MESVHSRNPVKEEKKHVFMGMEHELNPETHNDSNSDSYGLPQLSEKYNAL----------------------------------------------------------------------------------------------------RQNRSLIIQQTEIIGSAYNKWYLQAILLLSAFICGYGYGLDGNIRYIYTGYATSSYS------EHSL--LSTINVINAVVSAASQIIYARLSDV-FGRLYLFISAVILYVVGTIIQSQAY-----DVQRYAAGAIFYNAGYVGVILILLIILSDFSSLK--WRLLYQFVPTWPFIINT-WIAGNITSRANPV--V------NWSW-DVGMWAFIFPLSCVPIVLCMLHM-------QWR----------AR-------------------------------------KTPEWHALKGQKSYYQEHG------------------------------FIKIL--------KQ--------LF-----------WML----DVVGVLLMGCSLGCILVPLTLAGG------VKT----TWND------SRLIGPFVLGFVL-I-PILWI--WE-Y-------------------R-----FAR-D----------P-ILPYKLV-KDRAVWSSMGISFLIDFIY-YMAADYLYTVMIVAVNESVKSATRIATLSSFVSTV-ASPFFALLVT-R---------CTRL-KPFIMFGCAL-WMVAMGLL----YHFR----------------------------GG--S------QSH--SGIIGALCVWGVGTTLFTY-PVTVSVQSAVS-HE------NMATVTALNYTLYRIGSAVGSAVSGAI-W--TQTL-YKQILKRMGD------------------------VALATTAYESPYT------FIE--TYTWGTPQRNALMNA-YKYVQRLETIVALVFCVPLIAF--SLCLRD---P---KL-----TDT--------------------------------------VAVEYIEDGEYVDTKDNDPILDWFEKLPSKFTSKRE------------------------------------------------------------------------ Saccharomyces_cerevisiae_YJM789_sace_e_2345 -----------------------------------------------------------------------------------------------------------------MESVHSRNPVKEEKKHVFMGMEHELNPETHNDSNSDSYGLPQLSEKYNAL----------------------------------------------------------------------------------------------------RQNRSLIIQQTEIIGSAYNKWYLQAILLLSAFICGYGYGLDGNIRYIYTGYATSSYS------EHSL--LSTINVINAVVSAASQIIYARLSDV-FGRLYLFISAVILYVVGTIIQSQAY-----DVQRYAAGAIFYNAGYVGVILILLIILSDFSSLK--WRLLYQFVPTWPFIINT-WIAGNITSRANPV--V------NWSW-DVGMWAFIFPLSCVPIVLCMLHM-------QWR----------AR-------------------------------------KTPEWHALKGQKSYYQEHG------------------------------FIKIL--------KQ--------LF-----------WML----DVVGVLLMGCSLGCILVPLTLAGG------VKT----TWND------SRLIGPFVLGFVL-I-PILWI--WE-Y-------------------R-----FAR-D----------P-ILPYKLV-KDRAVWSSMGISFLIDFIY-YMAADYLYTVMIVAVNESVKSATRIATLSSFVSTV-ASPFFALLVT-R---------CTRL-KPFIMFGCAL-WMVAMGLL----YHFR----------------------------GG--S------QSH--SGIIGALCVWGVGTTLFTY-PVTVSVQSAVS-HE------NMATVTALNYTLYRIGSAVGSAVSGAI-W--TQTL-YKQILKRMGD------------------------VALATTAYESPYT------FIE--TYTWGTPQRNALMNA-YKYVQRLETIVALVFCVPLIAF--SLCLRD---P---KL-----TDT--------------------------------------VAVEYIEDGEYVDTKDNDPILDWFEKLPSKFTSKRE------------------------------------------------------------------------ 'Saccharomyces paradoxus NRRL Y-17217 sapa c38 10565' -----------------------------------------------------------------------------------------------------------------MESLNSHDHISGEKKHVSMGVEHELNPEAHNDSNSDSYGLPQLSEKYDAL----------------------------------------------------------------------------------------------------RQNRSLIIQQTEIIGSAYNSWYLQAILLLSAFICGYGYGLDGNIRYIYTGYATSSYS------EHSL--LSTINVINAVVSAASQIIYARLSDV-FGRLYLFISAVILYVVGTIIQSQAY-----DVQRYAAGAIFYNAGYVGVILILLIILSDFSSLK--WRLLYQFAPTWPFIINT-WIAGNITSRANPI--V------NWSW-DVGMWAFIFPLSCIPIVLCMLHM-------QWR----------AR-------------------------------------KTPEWHALKGQKSYYQEHG------------------------------LIKIV--------KQ--------LF-----------WML----DVIGVLLMGCSLGCILVPLTLAGG------VKT----TWND------SRLIGPFVLGFVL-I-PILWI--WE-Y-------------------R-----YAR-D----------P-ILPYKLV-KDRAVWSSMGISFLIDFIY-YMAADYLYTVMIVAVNESVKSATRISTLSSFVSTV-ASPFFALLVT-R---------CTRL-KPFIMFGCSL-WMVAMGLL----YHFR----------------------------GG--S------QSH--SGIIGALCVWGVGTTLFTY-PVTVSVQSAVS-HE------NMATVTALNYTLYRIGSAVGSAVSGAI-W--TQTL-YKQILKRMGD------------------------VALATAAYESPYT------FIE--TYTWGTPQRVALMNA-YKYVQRLETIVALVFCVPLIAF--SLCLRD---P---KL-----TDT--------------------------------------VAVDYIEDGEYVDTKDSDPILEWFEKIPSKFTSKRD------------------------------------------------------------------------ Debaryomyces_hansenii_CBS767_deha2e15070g -----------------------------------------------------------------------------------------------------------------------MTRSTDEETNNVSEEQLTNCEKSGRNTSSEIDNRSESMSGISEG------------ERPSQLGESDGNRNSKS-----------------------------------------------------------------------KKYYESNAGDGTKATDHHLTGLPLIATLVSCFTSLFIVALDQTIVSTILTTVGSEFH------NFEK--IGWLTSGYLLSLACLASIYGKVSIA-FGRKYTLVWGILVFEAGSVVCARAQ-----NMDTLIAGRVIQGIGGSCVQALTIIIMTEAVILS--RRALAFILIGVCFSLAS--VIGPFIGGAFAT--H--V---TWRW-CF---YVNLPVGGFAIVLLIVCF-------HPP-----------K--------------------------------------------------------------------------------------PKGNF--------KE--------KL-----------ARI----DYLGVFLLTSGLVLVLLGLTFGG-------VDF----SWNS------AAIILLFVLGGLL-I-IVFCI--YN-F-------------------K-----ISK-D----------P-IIIKEVI-IIPQIFAASWSATFNFAFF-MANLTYLAIYFQVIFNASPWQSGVDLLPMVISVSL-SSIANGVFMR-----------FTRYVKVTMLISTTL-GPIGCGLL-----LLL----------------------------EK--D------SPA--RDRIGLLIISGISVGLQFQ-SSLLAAQLEAP-PDVEG---SLILTTIFLNFLKSTGATVAVTLAQLI-Y--QATG-TSYINSLLNR---------LEKGS----TEYESLKKVPVKTLISTPS------LIQ----SLPDSAKEMVLDQ-FMKALKNVFYLGLAFSCAGFIV--SLFTTN---K---KI-----PRH-----------------------------------------------ENVKKAGDECDDEALIGDQNSTNADTAGNQLPPSIEGNK------------------------------------------------------------ Saccharomyces_cerevisiae_S288C_sace0e00330g ---------------------------------------------------------------------------------------------------------------------MDPGIANHTLPEEFEEVVVPEMLEKEVGAKVDVKPTLTTSSPAPSY----------------------------------------------------------------------------------------------------IELIDPGVHNIEIYAEMYNRPIYRVALFFSLFLIAYAYGLDGNIRYTFQAYATSSYS------QHSL--LSTVNCIKTVIAAVGQIFFARLSDI-FGRFSIMIVSIIFYSMGTIIESQAV-----NITRFAVGGCFYQLGLTGIILILEVIASDFSNLN--WRLLALFIPALPFIINT-WISGNVTSAIDAN----------WKW-GIGMWAFILPLACIPLGICMLHM-------RYL----------AR-------------------------------------KHAKDRLKPEFEALNKLK-------------------------------WKSFC--------ID-------IAF-----------WKL----DIIGMLLITVFFGCVLVPFTLAGG------LKE----EWKT------AHIIVPEVIGWVVVL-PLYML--WE-I-------------------K-----YSR-H----------P-LTPWDLI-QDRGIFFALLIAFFINFNW-YMQGDYMYTVLVVAVHESIKSATRITSLYSFVSVI-VGTILGFILI-K---------VRRT-KPFIIFGISC-WIVSFGLL----VHYR----------------------------GD--S------GAH--SGIIGSLCLLGFGAGSFTY-VTQASIQASAKTHA------RMAVVTSLYLATYNIGSAFGSSVSGAV-W--TNIL-PKEISKRISD------------------------PTLAAQAYGSPFT------FIT--TYTWGTPERIALVMS-YRYVQKILCIIGLVFCFPLLGC--AFMLRN---H---KL-----TDS--------------------------------IALEGNDHLESKNTFEIEEKEESFLKNKFFTHFTSSKDRKD------------------------------------------------------------------------- Saccharomyces_cerevisiae_EC1118_sace_b_1e8_0089g ---------------------------------------------------------------------------------------------------------------------MDPGIANHTLPEEFEEVVVPEMLEKEVGAKVDVKPTLTTSSPAPSY----------------------------------------------------------------------------------------------------IELIDPGVHNIEIYAEMYNRPIYRVALFFSLFLIAYAYGLDGNIRYTFQAYATSSYS------QHSL--LSTVNCIKTVIAAVGQIFFARLSDI-FGRFSIMIVSIIFYSMGTIIESQAV-----NITRFAVGGCFYQLGLTGIILILEVIASDFSNLN--WRLLALFIPALPFIINT-WISGNVTSAIGAN----------WKW-GIGMWAFILPLACIPLGICMLHM-------RYL----------AR-------------------------------------KHAKDRLKPEFEALNKLK-------------------------------WKSFC--------ID-------IAF-----------WKL----DIIGMLLITVFFGCVLVPFTLAGG------LKE----EWKT------AHIIVPEVIGWVVVL-PLYML--WE-I-------------------K-----YSR-H----------P-LTPWDLI-QDRGIFFALLIAFFINFNW-YMQGDYMYTVLVVAVHESIKSATRITSLYSFVSVI-VGTILGFILI-K---------VRRT-KPFIIFGISC-WIVSFGLL----VHYR----------------------------GD--S------GAH--SGIIGSLCLLGFGAGSFTY-VTQASIQASAKTHA------RMAVVTSLYLATYNIGSAFGSSVSGAV-W--TNIL-PKEISKRISD------------------------PTLAAQAYGSPFT------FIR--TYTWGTPERIALVMS-YRYVQKILCIIGLVFCFPLLGC--AFMLRN---H---KL-----TDS--------------------------------IALEGNDHLESKNTFEIEEKEESFLKNKFFTHFTSSKDRKD------------------------------------------------------------------------- Saccharomyces_cerevisiae_JAY291_sace_c_05195 ---------------------------------------------------------------------------------------------------------------------MDPGIANHTLPEEFEEVVVPEMLEKEVGAKVDVKPTLTTSSPAPSY----------------------------------------------------------------------------------------------------IELIDPGVHNIEIYAEMYNRPIYRVALFFSLFLIAYAYGLDGNIRYTFQAYATSSYS------QHSL--LSTVNCIKTVIAAVGQIFFARLSDI-FGRFSIMIVSITFYSMGTIIESQAV-----NITRFAVGGCFYQLGLTGIILILEVIASDFSNLN--WRLLALFIPALPFIINT-WISGNVTSAIGAN----------WKW-GIGMWAFILPLACIPLGICMLHM-------RYL----------AR-------------------------------------KHAKDRLKPEFEALNKLK-------------------------------WKSFC--------ID-------IAF-----------WKL----DIIGMLLITVFFGCVLVPFTLAGG------LKE----EWKT------AHIIVPEVIGWVVVL-PLYML--WE-I-------------------K-----YSR-H----------P-LTPWDLI-QDRGIFFALLIAFFINFNW-YMQGDYMYTVLVVAVHESIKSATRITSLYSFVSVI-VGTILGFILI-K---------VRRT-KPFIIFGISC-WIVSFGLL----VHYR----------------------------GD--S------GAH--SGIIGSLCLLGFGAGSFTY-VTQASIQASAKTHA------RMAVVTSLYLATYNIGSAFGSSVSGAV-W--TNIL-PKEISKRISD------------------------PTLAAQAYGSPFT------FIT--TYTWGTPERIALVMS-YRYVQKILCIIGLVFCFPLLGC--AFMLRN---H---KL-----TDS--------------------------------IALEGNDHLESKNTFEIEEKEESFLKNKFFTHFTSSKDRKD------------------------------------------------------------------------- 'Saccharomyces cerevisiae RM11-1A sace d 04406' ---------------------------------------------------------------------------------------------------------------------MDPGIANHTLPEEFEEVVVPEMLEKEVGAKVDVKPTLTTSSPAPSY----------------------------------------------------------------------------------------------------IELIDPGVHNIEIYAEMYNRPIYRVALFFSLFLIAYAYGLDGNIRYTFQAYATSSYS------QHSL--LSTVNCIKTVIAAVGQIFFARLSDI-FGRFSIMIVSIIFYSMGTIIESQAV-----NITRFAVGGCFYQLGLTGIILILEVIASDFSNLN--WRLLALFIPALPFIINT-WISGNVTSAIGAN----------WKW-GIGMWAFILPLACIPLGICMLHM-------RYL----------AR-------------------------------------KHAKDRLKPEFEALNKLK-------------------------------WKSFC--------ID-------IAF-----------WKL----DIIGMLLITVFFGCVLVPFTLAGG------LKE----EWKT------AHIIVPEVIGWVVVL-PLYML--WE-I-------------------K-----YSR-H----------P-LTPWDLI-QDRGIFFALLIAFFINFNW-YMQGDYMYTVLVVAVHESIKSATRITSLYSFVSVI-VGTILGFILI-K---------VRRT-KPFIIFGISC-WIVSFGLL----VHYR----------------------------GD--S------GAH--SGIIGSLCLLGFGAGSFTY-VTQASIQASAKTHA------RMAVVTSLYLATYNIGSAFGSSVSGAV-W--TNIL-PKEISKRISD------------------------PTLAAQAYGSPFT------FIR--TYTWGTPERIALVMS-YRYVQKILCIIGLVFCFPLLGC--AFMLRN---H---KL-----TDS--------------------------------IALEGNDHLESKNTFEIEEKEESFLKNKFFTHFTSSKDRKD------------------------------------------------------------------------- Saccharomyces_cerevisiae_YJM789_sace_e_1433 ---------------------------------------------------------------------------------------------------------------------MDPGIANHTLPEEFEEVVVPEMLEKEVGAKVDVKPTLTTSSPAPSY----------------------------------------------------------------------------------------------------IELIDPGVHNIEIYAEMYNRPIYRVALFFSLFLIAYAYGLDGNIRYTFQAYATSSYS------QHSL--LSTVNCIKTVIAAVGQIFFARLSDI-FGRFSIMIVSIIFYSMGTIIESQAV-----NITRFAVGGCFYQLGLTGIILILEVIASDFSNLN--WRLLALFIPALPFIINT-WISGNVTSAIGAN----------WKW-GIGMWAFILPLACIPLGICMLHM-------RYL----------AR-------------------------------------KHAKDRLKPEFEALNKLK-------------------------------WKSFC--------ID-------IAF-----------WKL----DIIGMLLITVFFGCVLVPFTLAGG------LKE----EWKT------AHIIVPEVIGWVVVL-PLYML--WE-I-------------------K-----YSR-H----------P-LTPWDLI-QDRGIFFALLIAFFINFNW-YMQGDYMYTVLVVAVHESIKSATRITSLYSFVSVI-VGTILGFILI-K---------VRRT-KPFIIFGISC-WIVSFGLL----VHYR----------------------------GD--S------GAH--SGIIGSLCLLGFGAGSFTY-VTQASIQASAKTHA------RMAVVTSLYLATYNIGSAFGSSVSGAV-W--TNIL-PKEISKRISD------------------------PTLAAQAYGSPFT------FIT--TYTWGTPERIALVMS-YRYVQKILCIIGLVFCFPLLGC--AFMLRN---H---KL-----TDS--------------------------------IALEGNDHLESKNTFEIEEKEESFLKNKFFTHFTSSKDRKD------------------------------------------------------------------------- Saccharomyces_mikatae_IFO_1815_sami_a_c202_5644 ----------------------------------------------------------------------------------------------------------------------MDPATANHALPEDFTEDVVPDILEKEVGAIVDVNPTLTTSSPAPS---------------------------------------------------------------------------------------------------YIELIDPGVYNIEIYAEMYSRPLYRVALFFSLFLIAYAYGLDGNIRYTFQAYATSSYS------QHSL--LSTVNCIKTVIAAVGQIFFARLSDI-FGRFSIMIVSVIFYSVGTIIESQAV-----NITRFAVGGCFYQLGLTGIILILEVIASDFSNLN--WRLLALFIPALPFIINT-WISGDVTSAIGTN----------WKW-GIGMWAFILPLACIPLGICMLHM-------RYL----------AR-------------------------------------KHAKDRLKPEFEALNKLK-------------------------------WKSFC--------ID-------IAF-----------WKL----DIIGMLLITVFFGCVLVPFTLAGG------LKE----EWKS------AHIIVPEVIGWVVVL-PLYML--WE-M-------------------K-----YSR-H----------P-LTPWDLI-KDRGIFFALLIAFFINFNW-YMQGDYMYTVLVVAVHESIKSATRITSLYSFVSVI-VGTILGFILI-K---------VRRT-KPFIIFGISC-WIVSFGLL----VHYR----------------------------GD--S------GAH--SGIIGSLCLLGFGAGSFTY-VTQASIQASAKTHA------RMAVVTSLYLATYNIGSAFGSSVSGAV-W--TNIL-PKEISKRISD------------------------PTLAAQAYSAPFT------FIT--TYTWGTPERIALVMS-YRYVQKILCIIGLVFCFPLLGC--AFMLRN---H---EL-----TDS--------------------------------IALEGNDHLKSKDSFETEEKQESFLKSMIFTRFTRSEDKRN------------------------------------------------------------------------- 'Saccharomyces paradoxus NRRL Y-17217 sapa c356 5984' ---------------------------------------------------------------------------------------------------------------------MDPATANHTLTEEFTEVVVPEMLEKEAAATVDVNPTLTTSSPAPSY----------------------------------------------------------------------------------------------------IELIDPGVHNIEIYAEMYNHPVYRVALFFSLFLIAYAYGLDGNIRYTFQAYATSSYS------QHSL--LSTVNCIKTVIAAVGQIFFARLSDI-FGRFSIMIVSIIFYSMGTIIESQAV-----NITRFAVGGCFYQLGLTGIILILEVIASDFSNLN--WRLLALFIPALPFIINT-WISGDVTSAIGTN----------WKW-GIGMWAFILPLACIPLGLCMLHM-------RYL----------AR-------------------------------------KHAKDRLKPEFEALNKLK-------------------------------WKSFC--------ID-------IAF-----------WKL----DIIGMLLITVFFGCVLVPFTLAGG------LKE----EWRT------AHIIVPEVIGWVVVL-PLYMI--WE-M-------------------K-----YSR-H----------P-LTPWDLL-QDRGIFFALLIAFFINFNW-YMQGDYMYTVLVVAVHESIKSATRITSLYSFVSVI-VGTILGFILI-K---------VRRT-KPFIIFGISC-WIVSFGLL----VHYR----------------------------GD--S------GAH--SGIIGSLCLLGFGAGSFTY-VTQASIQASAKTHA------RMAVVTSLYLATYNIGSAFGSSVSGAV-W--TNIL-PKEISKRISD------------------------PTLAAQAYGSPFT------FIT--TYTWGTPERIALVMS-YRYVQKILCIIGLVFCFPLLGC--AFMLRN---H---KL-----TDS--------------------------------IALEGNDHLESRNSSETEEKEESFLKSKFFTQFTSSKGKEN------------------------------------------------------------------------- Debaryomyces_hansenii_CBS767_deha2d01210g ---------------------------------------------------------------------------------------------------------------------MSNQSNDIAVKSAGESFGSNNSTDLTEKHLAVRNIRDEEAQAPKEK----------------------------------------------------------------------------------------------------KFIESDAGDGSRREDQYLHGPK-LALCFVAIFLCLFLVALDQTIVATLLTVVGNKFD------GFDK--IGWLSAGFLLSMAVFAATWGKISII-FGRKITMFIAIILFEAGSLMCALAN-----DMNVLIGGRVLAGVGGGGIQSMVFILISEIVPLE--VRPLGMAGLGCTFAVAS--VLGPLIGGAFTS--N--V---SWRW-SF---YINLPIGGIAAAFFFWAF-------NPP-----------K--------------------------------------------------------------------------------------TKGNI--------RE--------KL-----------KMI----DYLGTVLLSAGLVVFLLALTFGAG------DQF----SWDS------AAVICCFVLGGAV-L-IVFCI--WN-F-------------------K-----YSK-N----------P-IIPPDIV-KALGVDASTLMIFGMFGYF-MAIVLYVSIYFQVIHGADAWHSGLHLLPIIIPVVL-TSISSGILIH-K---------TRFV-KPFGLFGAIM-GPIGIGLL-----CLL----------------------------DV--D------SSS--SRQIGLLIISGISCGFQMQ-AALISSQISAP-KTPG----GTILTTTFVNFGRAVGGTIGADLADAV-Y--SAAF-QNNFATALSN---------LNDKL-----ILSELSQINERALVTSTD------VIK----TLSPGAQHFVKNQ-VMEAIRNVFYMSLGFSALGLIG--CICTTN---K---RL-----PKV--------------------------TGGQMAADEAKEETNEGTTNNNRSSSSLSDKNQDILVDRLNNDNLENVPEQTENRRE--------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0g06600g -----------------------------------------------------------------------------------------------------------------MSTKNNETDSPLESVSSNSNSHIGTDVEKYQYSNTHGDSIPDNYDSHFEE----------------------------------------------------------------------------------------------------EEEKSYGVQKVEILNKQYNHLWGKSAIFFSLFLMGFVFRLDSMVRRSMNAYATNSYK------QHSL--LSTVNVVRSVAAACGLPLYSRLSDV-FGRIELIVVSVLLYVAGTIICTQAY-----DVTRYAAGMILYQFGLCGLAILFKVIAADFSNLN--WRVFCTLISAAPFIINT-WVSGDIVEAIGDN----------WSWPGIGVWAICLPVATIPLVLCFIHM-------QYL----------AK-------------------------------------KSGDLNQLRGMQTEYKRLG------------------------------FKKFV--------VE-------VFF-----------WKL----DIFGVLSLMIILGLILTPLTLAGG------ETA----EWRT------AKVIVPLILGFCW-I-PVFAF--WE-N-------------------R-----IAT-H----------P-IAPTDMF-RDRGVYCALGIGILIDFCW-YMQGDYLYTILVVAIHESVKSATRINSLYSFSTII-TGLCVGLAIS-K---------VRKM-KCFIVFGVCM-WLVAFGIM----IKYR----------------------------GG--S------QSH--GGMIASQVLLGFGGAFFTH-PVQASLQAYVN-HE------RMATITTLYAISYYIGSAVGSSVSGAI-W--TQVL-PNEIGKRFTN------------------------KTLARLAYSAPLS------FIK--KYTWGTPLRMELVEA-YRHVQKLLIIVGICFCVPILGF--ALFLRDPVLISAQNI-----VDA-----------------------------------------------EDKEVKEYYGYNPLKWEFNGKTVAQYLGLKQN------------------------------------------------------------------- Yarrowia_lipolytica_CLIB122_yali0c06105g --------------------------------------------------------------------------------------------------------------------------------------MAFAVED--------KYKSLCQKLFFSRV----------------------------------------------------------------------------------------------------PVKHYPRKHCNTNAKERGWTTTTVIVGWIFIYLYASGKTIAQHLFPSLAPFATSHFS------GLAL--LSSQAVVESAIFVVARPACAKISDH-LGRLEAWIVVVVAHIIGAVLYAASP-----NIGCYFAGTVFWEIGMVGGHLMMELYAADTSTTE--TRVLASYFIQSPSVWAP-WISAPVVAGFLKV--T------TWRW-GYGSMAIIIPGTSIGIIITLLYM-------RLK---------YEN----------------------------------RLGGQGDFYSPGG---------------------------------------PMRFI-------------------------------KSF----DIIGLLAVGGAMILFFLPITFAAG------TDK-----WKY------HSYIAMLTIGSFL-M-VFTPI--WE-V-------------------Y-----GTK-T----------P-LIPWKLF-KSRIMVISSAQMFLLSMAN-KIYIPYFITWLLVVKGQSPKAATNVSSTLIVTANAWGLFAVAPYMW-W---------RGHC-KRVIVIGTCL-HLVGIGMT----YHYR----------------------------TP--H------GSL--AVMIIAQVFEGVGRGMIYI-PAVAMAQAVFD-KH------KVASVTALYYTTGGVGQVIGDSISGAI-Y--RTLY-PKYIHKYAPD------------------IPAKDLNMIINK-IKKATK------------YPMGSKVRTEINMA-FNEAMRHMLLGPFGCVAGMIVL--SLFYPM---V---NL-----KEA------SDDVYDAPDNSDGEDIFTPHPAPGTEGDLEKQHSGDEKFESNSENGEHTNSEEGNLPRVSAEAAAASYINNTQVL----------------------------------------------------------------- Kluyveromyces_lactis_CLIB210_klla0e09879g --------------------------------------------------------------------------------------------------------------------------MSSLAKQVSSTSLDKNSTV--------NIIFSLVKRESEPV------------SKKYEDKKAGEDAEDVPV----------------------------------------------------------------------DLKNVFTSDNEKTQSSIMAGMR-LYVCLFALVLAQLIVALDVFIVNTVIDVVSKNLG------GYAK--SGWLITGYSLPNSLLSLIWGRATSL-LGFQSSMLISIFIFEVGSIVSATAT-----SMNNLVVGRVVAGIGGSGLQTVSMIIGCSLVEER--NRTIVIAVIMSAFAVSS--LIGPFIGGAFTT--H--A---TWRW-CF---WISLPVGGSAAFLFFFTY-------NPE----------------------------------------------RLSITARLVRCLKLVKAIPLKQFQYVET------------------------YKTIV--------RN--------LV-----------FRF----DLIGFTLNCTGICLFLLGLTFGS-------EDN----SWKR------AFVVCFLVIGGLL-V-VCSVV--YD-F-------------------Y----IFDR-INPEPANASYRP-LMVRTLI-GHKYFLLANTVTCAAAVVF-AGYMVYSVQFFQLVLGYTAWNAGLHLIPLVIASLL-SAIFCGGFTK-K---------TGHV-KYVMIANIAL-LLIGSGVC-----TLL----------------------------DN--Y------SNN--SMQIGVWILPGFGLGATLQ-CALISSQLQID-KNSPDAKTELVEITAFNSFCKSLGSSIGAVLSTTT-F--ISAL-WRK----INK---------AKLEG----YYGKKINELVKY-RLQNFD-------------GKSTEAAEI-----FSAAVTYVFWMCYAFSALAFFC--ACLSSN---R---RV-----ETE-----------------------------------------------KKVAQEEHDGLPSIPEFKQGTTV---------------------------------------------------------------------------- 'Saccharomyces castelli NRRL Y-12630 saca 713.30' ---------------------------------------------------------------------------------------------------------------------MEIKSIELTGEGKKNPEILVSIDSFGIEPSMEIASHGINEESGTDA------------EVSNHVE---------------------------------------------------------------------------------KKPNFNSKYGKNAMGEDLPSGIVLYTCAFSLALAIFLAALDIMIVSTIIEDVAKKFG------AYSK--TGWIFAGYSLPNALLALLWGRIASI-IGFKSCMLAAIIIFEIGSLISGVAN-----SMNMLIGGRVIAGVGGSGIQSLAFVIGSNLVDER--RRGLIIACMSSAFAVAS--VIGPFLGGAFTT--H--A---TWRW-CF---YINLPVGGVAFALFVVFY-------NPQ----------RK-------------------------------------SLEGISILSSLKEFCNTLRQITVIKNLKNWPT-----------------WKSIV--------YS--------LV-----------FRF----DIIEFIFCSAGFVLVLLAFTFGG-------NQY----NWSS------ASIIVMFVIGIIL-L-IVSLL--YD-FVIFPRFKAVKE--------N-----SLY-Q----------P-LIKWSIF-SHPGIFTANAALFFECTAY-ICQTVYIIQFFQLVRGNTAWKAAVHLIATVVPTVI-TTFSSGIANS-K---------FGLV-KHVTFIGVVT-SLVGAGLL-----TLL----------------------------DN--N------SSS--AKHIGLLILPGIGFGATMQ-STMIGAQIQLD-KKAVTYRSDFIAVTTLNAFLKGAGQALGGIICDTV-F--SASI-VNK----LNA-----NDLHVPGGN--------TVNNLIGY-RDQNFD-------------GTDSLMSKLISES-----IINVFYIALGLAACSFIF--GVFTSN---K---KV-------------------------------------------------------DVRKRLVDEESQEPEKD---------------------------------------------------------------------------------- Saccharomyces_kudriavzevii_IFO_1802_saku_c1947.4 -------------------------------------------------------------------------------------------------------------MVSVGPHDNIGSEKKHVPLDIEQELNPEAHTDSHSSSYARDDTLPQMSGKYDAL----------------------------------------------------------------------------------------------------RQNRSLIIKQTEIIGTAYNKWYLQAILLFSAFVCGYGYGLDGNIRYIYTGYATSSYS------KHSL--LSTINVINAVVSAASQIIYARLSDV-FGRLYLFISAVILYVVGTIIQSQAY-----DVQRYAAGAIFYNAGYVGVILILLIILSDFSSLK--WRLLYQFAPTWPFIINT-WIAGNITSRANPV--V------NWSW-DVGMWAFIFPLSCIPIVLCMLHM-------QWR----------AG-------------------------------------KTPEWQELKGQKSYYQEHG------------------------------LMKIL--------EQ--------LF-----------WKL----DVIGVLLMGCSLGCILVPLTLAGG------VKT----TWND------SRLIGPFVLGFVL-I-PILWV--WE-Y-------------------S-----YAR-D----------P-ILPYKLV-KDRGVWSSMGISFLIDFIY-YMAADYLYTVMIVAVNESIKSATRISTLSSFVSVV-ASPFFGLLMT-R---------CTRL-KPFIMSGCSL-WMLAMGLL----YRFR----------------------------GG--S------ESH--SGIIGALCVWGVGTTLFTY-PVTVSVQSAVS-HE------NLATVTALNYTMYRIGSAVGSAVSGAI-W--TQTL-YKQILKRMGD------------------------VALAASAYDSPYV------FIE--TYTWGTPQRVALMGA-YKYVQRLETIVALVFCVPLIAL--SLCLRD---P---RL-----TDT--------------------------------------VAVENIKDGEYVDTKDSDPILEWFEKIPSKFTSKQD------------------------------------------------------------------------ Yarrowia_lipolytica_CLIB122_yali0c02541g ----------------------------------------------------------------------------------------------------------MKWLTSLRNSVVGGPHLYNNDKDSCSECDSDTESVSWTRKMFDPPVKQQREDYTDSE----------------------------------------------------------------------------------------------------DEAGAPSGSREMEQLTTIWTKTDLYMAWASMLLLSVAIGMMIQTVSVYSTYATSDFN------QMSL--LSALNVVKSVMYIATRPILAKFADV-LGRFETVLICIVIFTVGFIMLSASP-----NIGTYFAAHIFYIFGQVGIQFMEQVFAADTSDLK--NRMFFVVLPNLCYLFTP-WCAAPITNAILKH--S------TWHW-GYGMWCITVPVVSIPALTIMFRH-------RMK----------AR-------------------------------------KMGLECARS----------------------------------------GLSNV--------KT--------AM-----------RQF----DIIGLILFTGGISLLFLAVTLVKT------SKS-----WSQ------PHVLSMIIIGPIL-L-ILFPI--WE-K-------------------L-----YPK-Y----------P-FLPFSAL-KDRTLITGCIIVALYSLAY-YIYAPYYTAWLLVCKNLSVTAATNTRVTWTVASTF-GSLLVAPLIR-Y---------TYRL-KPTIILGGCL-YMLGLGLT----YRYR----------------------------QP--D------NSL--AQFIIAQVIEGLGTGMIQY-PVLVLIQAVVS-HK------QVVAATAIFYSSISVGGVIGDAISGSM-Y--RQQY-PKR----LAD-----YAPFLS---------EKDIDTMVNN-VNAPLK------------YAWGSEERTAIIAA-FNNVYRHLLYGPVIVGGALILF--AVTLPN---V---DL-----SQM--------------------------------EERVKGVVFGNTNKKETERNDDENQDLGSEKSCQKDNVVETKV----------------------------------------------------------------------- Debaryomyces_hansenii_CBS767_deha2a14696g -------------------------------------------------------------------------------------------------------------------MLAEKNSHNTGDIITPTVTKYSQTATASGVDKTTSAVEKLHHESVSES------------KELHLIDSNISTEFE-------------------------------------------------------------------------KSRGVRRIENVKAMMQSDEGKKVTIAFWTCLVVIAWVYSLDSSTTYNYAIPAASNFS------RHSM--ISTVNIASGIIGSVVLPFQAKFSDI-TSRPICFALSLLFYTVGTVIAASSS-----SIGGYVVGTVFTAVGSNGISFLRDIIVADLTDLK--WRGLVNGIMTSPYLITV-WFAGLIVDAVLKT---------NWRW-GYGMFAIIMPVIVSPLIFVLSYY-------EHK-------------------------------------------------AQKLVPKVVK---------------------------------------PKKSV--------WK--------IV-----------KDAAIEIDAFGLILLGFGWSLFLLPFSIYSY------ADK----GWKN------PSIIAMLVVGPVL-L-IIFVV--YE-V-------------------F-----YAP-F----------P-SMPKRVI-KNKTFVTAIIINIIYLLAD-GIRAQYLSTIMWIGKDWSNQNWVYFNNTLTMSLCF-FGVVAGATCR-I---------THRY-KYMQSFGILV-RVISYCLP------LR----------------------------SQ--G------TLANTASFVMSQVLMGFGSAYSTI-GTQISSQASVP-HQ------DLSLVMSLVLLWSTVGSSIGYAISSVI-W--TSKL-PQYFREFIPN----------------------SYTDEEVYNFYTDMD------LLR--AMPFDSDARQGATKA-FTYVAIFMFAPPIAMEFINFLL--SFFQTN---F---YL-----GDT------------------------------------------HNAIEDQNGKDPTNPDEEIRVPQTTKEKFLYLFR---------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0b12716g ---------------------------------------------------------------------------------------------------------------------------------------------------MDNCGKDIESMGVIVE----------------------------------------------------------------------------------------------------DRSSAQDESSGHVGDPQPLSGFKLYANMGSLTLVLFLAALDILIMSASIEVISEQFN------DYSK--SGWIVSGYSLPEALLTLLWGRFATI-FGFKLSLLLSILIFETGSLISAVSN-----SMNVLIGGRVVAGIGGSGIQSLCFVIASTLTTER--SRGVAISVLSCAYAVAA--VAGPFMGGAFTT--H--V---TWRW-CF---YINLPIGSLAFAVLVLTY-------KPH----------EG-----------------------------NSARSIVSVLKSCCEFGTARLFSKDL-------------------------------YLKMF--------DE--------LV-----------FGF----DFIGFIFCSVGFILFLLGLTFGG-------DKY----AWSS------GAIIVYFIVGVTI-S-VAFLL--YD-FMIFPKFGRVRK--------N-----ASF-R----------P-LVPWSVV-SRPGIATAVAANFLMCVAY-SAQVVYIIQFFQLVRGSDAWRASIHVVALEIPDII-TVAISGAISR-M---------TGHV-KPIIFVGIIA-GLVGAGLL-----TLL----------------------------DN--D------SGS--SKHIGLLILPGVAFGAMLQ-GSLLSCQLQIP-KDSASFMPDFVSTTTVHTFSISLGMSFGSVLATMV-F--GTSL-HNK----IAS---------SGFEF----LSTKSVDELVSY-RIQNFD-----------------GTRSGLGYI-FGNSIKNVFWMALGLCALAFIF--GIFTSN---E---KLNLESTGKT----TCKR------------------------QEREERGGEKEEGEGEEVEEKEEEEEEKFATKNTQSTENAENTDTLEKSG---------------------------------------------------------------- Candida_parapsilosis_CDC_317_capa_03952 -----------------------------------------------------------------------------------------------------------MSKKQVNSATSSVKSTDSSGLPQPLTKDNTDDIQPQQQPQQLPEDLEDQSSVGSRH----------------------------------------------------------------------------------------------------GHFKESDAGDGTLREDQYIHGPRLVLCFVSLFLCLFLFALDQTIVATILSTVGNKFD------AFEN--VGWLSSGFLLTMAVFIQPYGKLSII-FGRKWSMIVAIVIFEAGSLMCALAS-----SMNVLIGGRVLAGVGGAGIQGLTFVIVSEVVPIN--KRPLGMTILSVTFAVAS--VLGPLIGGAFTT--H--V---TWRW-SF---YINLPVGGFALAVFLYSF-------RPP-----------L--------------------------------------------------------------------------------------PKVDI--------WE--------EL-----------KQF----DYIGTFFFISGSVILLLAITFGS-------SDF----PWNS------GAVISCFVLGPVL-L-IVFAI--WN-F-------------------R-----FSK-N----------Q-IIGTDVI-TTPQIIASALSISGIFSAF-IVTMIYASVYFQVIRDSSAMGAGLHLLPCIIATVI-SSVVSGGAIQ-----------KLKYVKPWGVFSGVL-APIGAGLL-----SLL----------------------------RV--D------SPF--SKQVGLLIIMGAATGSQFQ-PAMLSAQIKAP-KTPG----GTIMTTIFVNASRCLSSAIAATLSDAV-Y--TSSL-NNFFKKNIPK---------------ASAEVQQSLQSIDISNLMSNNA------ILR----TLDPATEKFIKEQ-MMKSIQNVFYMCIGLAAITTLA--CPFVSN---K---KL-----PDT----------------------------KQVAKVEKKKEEIEQGDATEAEKEAQLKELDAELTDSTPQDLPNESNKVETK------------------------------------------------------------------ 'Lodderomyces elongisporus NRRL YB-4239 loel 04525' -------------------------------------------------------------------------------------------------------------------------MTKQNSNKGGTSSKSNPTQSQRRPSQHLTLSPNIIQDPSAET------------SGLIANELAAESDILTPFDNPNKSTTYGSIDAESANNIAYTNIKSTGTTGTTGTTGTIG-----------------------------ATSEIPNDENDDPYNGYALPKAQLYTVVSSLFMASFLAALDATVVTTLLSLIASELH------AVQN--ISWIATAYLLSSAAFQPIFGKISDI-FGRKVLICGCSILFSLGCLICVTN------SLFWLVIGRFVTGIGGSGMTSIGTMTMSDLVPLR--DRGLFQGLANIFFGLGS--ASGGVIGGVIAD--T--L---GWKY-VF---ALQVPLGLFVAFAIYSYL-------NLP----------AG-----------------------------------------SPGLGY---------------------------------------HDEDV--------WS--------KL-----------KRV----DFLGSFVLISALLMFLTAASMGG-------REF----AYSS------RTFLGLSIGSAIL-F-LAFIY--VE-A-------------------Y-----ISE-E----------P-IIPIHLL-GNRTVLSSSLTNWFFTMAV-FTTLFYVPIYFTSVMNLTASENGLRLVPNFFGVSL-GSVGAGYYMK-H---------YGKY-YNLAVVSGIL-VILGITRI-----TMI----------------------------SP--K------IPL--WQQMVLLLPSGLGYASILT-ITLLALISATP-MK------FQACTTSIQYTFRSTGSTLGVSVASAI-F--SNVL-LQQ----LTK-----KINAIVTND------PEKARKIIAK-ALDSTD------YVN----EAPKYVRAAIRDS-YEAGCKGAFYFALLTVVLGFVS--SLFMRE---N---KL-----HTS-----------------------------------------------LNRD----------------------------------------------------------------------------------------------- Pichia_pastoris_GS115_pipa_3g03640 -----------------------------------------------------------------------------------------------------------------------MSAESVSDKGSSGTPPVVNETT--------VNNATGPKKVVPRV------------EGLRSNNIHLFN----------------------------------------------------------------------------LEEKTYGVKRIEVLAKQYKSPLAYVVFFFSIFLVAYAYGLDATMRGTLQSYATSSYA------EHSR--IATVNVVRSATSALAQPIYARLSDN-FGRLELFLVSIVLYVVGTIVMSQAY-----DFPRFAGGSVLWQFGYSGVIILIQIMSADASTLN--WRVACSFVAALPFIINT-WVSGNIIEVASTN----------WSW-NIGFWAFAFPLACLPLIGCFLHM-------WFL-----------------------------------------------SIKNGDMRRLKEEDQSDFRKLG-----------------------------FKKFM--------VE-------VFF-----------WKL----DFVGLFLLTLVIGLILVPISVAGG------IEN----QWAT------ADILVPFFLGWAC-I-PFFAV--WE-I-------------------K-----YAR-N----------P-LLPSDMV-KDRAVWSALFIGVFLTFIW-YMQGDFLYTALVVSFNESTKSAQRIASLYSFASVI-TGSLLGLVLV-R---------IRRL-KPFVLFGVSG-WMLAFGLL----IHYR----------------------------GD--T------RSH--GGVIGAQVLLGFFAGFFTY-PVQASIQAVVD-HE------RMAIALALYLTSYNIGGAIGGAVSGAV-W--QDIM-PRELEKGFAD---------------------FTNTTLSVFAYGSPFE------FIL--EYPWGTPERMVVVEA-YKYTQKILCIIGVCLCIPLIGA--AFLLRN---P---ELKSVQSFEL-----------------------------------------------DVSTTTDEDGEKYYETEGYKAEKNSLWQRMMNLFKL--------------------------------------------------------------- 'Saccharomyces bayanus 623-6C saba a 602.6' ------------------------------------------------------------------------------------------------------------MESTDSHDSTTVEKKRVPMNKEHELKSDGHVNTTSDSDSHAFDSIPQLSGKYDAL----------------------------------------------------------------------------------------------------RQNKSLVIKQTEIIGEAYKKWYFQAILLISAFVCGYGYGLDGNIRYIYTGYATSSYS------EHSL--LSTINVINAVVSAASQIIYARLSDV-FGRLYLFISAVILYVVGTIIQSQAY-----DVQRYAAGSIFYNAGYVGVILILLIILSDFSSLK--WRLLYQFAPTWPFIINT-WIAGNITSKANPV--E------NWSW-DIGMWAFIFPLSCIPIVLCMLHM-------QWI----------AR-------------------------------------KTPEWHALKDEKSYYQEHG------------------------------FVKVL--------EQ--------LF-----------WKL----DVIGVLLMGCSLGCILVPLTLAGG------VKT----TWND------SRLIGPFVLGFVL-I-PILWV--WE-Y-------------------R-----VAR-D----------P-IIPYKLV-KDRGVWSSMGISFLIDFIY-YMAADYLYTVMLVAVNESIKSATRISTLSSFVSVV-ASPFFGLIMT-R---------CTRL-KPFIMFGCCL-WMLAMGLL----YRYR----------------------------GG--R------ESH--SGIIGALCVWGLGTTLFTY-PVTVSVQSAVS-HE------NLATVTALNYTLYRIGSAVGAAVSGAI-W--TQTL-YKQILKRMGD------------------------VTLATAAYTSPYT------FIE--TYTWGTPQRVALVNA-YKYVQRLETIVALVFCAPLIAF--SLCLRD---P---KL-----TDT--------------------------------------VAVENIEEGEYVDTKDNDPILDWFKKFTSKFSSSKKE----------------------------------------------------------------------- Saccharomyces_bayanus_MCYC_623_saba_b_c633_10089 ------------------------------------------------------------------------------------------------------------MESTDSHDSTTVEKKRVPMNKEHELKSDGHVNTTSDSDSHAFDSIPQLSGKYDAL----------------------------------------------------------------------------------------------------RQNKSLVIKQTEIIGEAYKKWYFQAILLISAFVCGYGYGLDGNIRYIYTGYATSSYS------EHSL--LSTINVINAVVSAASQIIYARLSDV-FGRLYLFISAVILYVVGTIIQSQAY-----DVQRYAAGSIFYNAGYVGVILILLIILSDFSSLK--WRLLYQFAPTWPFIINT-WIAGNITSKANPV--E------NWSW-DIGMWAFIFPLSCIPIVLCMLHM-------QWI----------AR-------------------------------------KTPEWHALKDEKSYYQEHG------------------------------FVKVL--------EQ--------LF-----------WKL----DVIGVLLMGCSLGCILVPLTLAGG------VKT----TWND------SRLIGPFVLGFVL-I-PILWV--WE-Y-------------------R-----VAR-D----------P-IIPYKLV-KDRGVWSSMGISFLIDFIY-YMAADYLYTVMLVAVNESIKSATRISTLSSFVSVV-ASPFFGLIMT-R---------CTRL-KPFIMFGCCL-WMLAMGLL----YRYR----------------------------GG--R------ESH--SGIIGALCVWGLGTTLFTY-PVTVSVQSAVS-HE------NLATVTALNYTLYRIGSAVGAAVSGAI-W--TQTL-YKQILKRMGD------------------------VTLATAAYTSPYT------FIE--TYTWGTPQRVALVNA-YKYVQRLETIVALVFCAPLIAF--SLCLRD---P---KL-----TDT--------------------------------------VAVENIEEGEYVDTKDNDPILDWFKKFTSKFSSSKKE----------------------------------------------------------------------- Kluyveromyces_lactis_CLIB210_klla0a10439g ----------------------------------------------------------------------------------------------------------------------MSTEKNSVVGEDKVLKSTYSDDETNVIKSVNGAGVGVDEKQAGPT------------DLNEYGIPDYL-----------------------------------------------------------------------------KSSKSLTIRKTEILAEQYSSWQWRVVLLFSAFLCGYGYGLDGNLRSFYTTWATNSYS------THSL--LSTIGVVNAVMGAASQIVYARLSDV-YGRFTLFVTAIVFYVVGTIIESQAH-----DVQRYAAGAVFYNIGYVGVILIVLLILSDFSSLK--WRLFYSFVPTWPFIINT-WISGNIVDVAKPE--Q------NWSW-DIAMWAFIFPLSCLPLLGCMLHM-------KWR----------AR-------------------------------------QTEAWKELSSQKTYYQTHG------------------------------LVQSL--------VQ--------LF-----------WKL----DVIGVFFMIIILGCILVPLTLAGG------ISN----KWNN------PHIIAPFILGFVL-I-PFFIA--WE-S-------------------K-----WAR-E----------P-IAPFKLL-RDRGIWAALCIAFLINFIF-TMAAGYLYTILMVAVNESVTSATRISSVSTFTSTV-FSPFFALFIT-R---------FTRL-KPFIIAGCSL-WMVAMGIL----FHFR----------------------------SG--Q------NSD--KGIIGALVVWGLGTTMFTY-PVTVSLQSVTS-HE------NMATVTALSYTMYRIGSAVGSAVSGAI-W--TQLL-YKQLLQHLDG-----------------------DATLAASFYGSPLT------YIA--QYPWGTPVRDGVVQA-YRYVQKYEVLVALVFTAPLFVF--SLCLRD---P---PL-----TNE--------------------------------------VAHENIKQGEYVDVEDDDPVANWIHDKWSRIRRKSD------------------------------------------------------------------------ 'Saccharomyces castelli NRRL Y-12630 saca 514.3' -------------------------------------------------------------------------------------------------------------------------MSSVSTTDQDIHNLSTQAHTQDDSIKKETVSATINSVSSLSE----------------------------------------------------------------------------------------------------ESVKDAGVNNIEIYAEQYQNPFLRAMLFFSLFLVAYAYGLDGNIRYTFQALATSSYS------EHSL--LSTVNCIKTVIAAAGQIWFARASDI-FGRLTILGVSIIFYIIGTVIESQAT-----NVARFTAGGCFYQLGYTGAMLIIEIIATDFSNLN--WRLLALFIPALPFIINT-WISGDVTAAVNGN----------WKW-GIGMWAFIFPLACIPLACCMLHM-------RYL----------AH-------------------------------------KNAKDRLMPSFTIPKDVS-------------------------------RKEYF--------ID-------VFF-----------WRL----DMIGLLLIVCFFGCVLIPFTLAGG------MKE----QWRT------AHIIVPEVIGWCVAL-PLYIL--WE-I-------------------K-----FSR-H----------P-LTPWELL-KDRGVYSALIIAFLINFCW-YMQGDYMYTVLIVAVHESVKAATRITSLYSFVSVI-TGTILGLFLV-K---------LRRT-KPFILFGICG-WFISFGLL----IHYR----------------------------GD--S------GAH--AGIIGSLCLLGFCAGFFTY-TTQTSIQATTRSHA------KMAVITALYLACYNIGSSFGAAVSGGV-W--TNVL-PDRISRGISN------------------------QTLAAEAYGSPFT------FII--TYTWETAERQAVVKA-YRETQKILCIIGLVFCVPLLMA--ALMLRD---H---KL-----EDV-----------------------------------------VALDQMSEKVVEDDDPIFAFLKKCIPFYNKKNGETSTVTTSTDGNDVVEMV------------------------------------------------------ Saccharomyces_cerevisiae_JAY291_sace_c_05665 --------------------------------------------------------------------------------------------------------------MSGIVSVTDSTSGRLDVNERSGVKARNDAGEKDLVTVNDGLRQVPTSISSCNG----------------------------------------------------------------------------------------------------EKIIKTRGVTRIEVVRERMSTKVTWILGLSIFLTSWVAALDATTTYNYQPYATSSFN------RHSM--LSTLTIANSVIGAVCKPFIAKISDL-SSRPVTYFVVLVLYVIGFVITACSP-----TIAAYVIGSVFIAIGQSGISLMNMVIIADTTTLK--WRSFFTSLLSVPYLVTT-WISGYIVEDIINS---------NWRW-GYGMFAIITPVALTPAILVMAYL-------EHQ----------AN-------------------------------------KTGEIPVGSDPLAKKKVEVTESHISGFKQ--------------------YLELL--------KA--------SL-----------IEI----DAFGLILLGFAFSLILLPCSLYSY------AEG----GWNN------PSMIAMEVVGGIF-L-ITYVV--FE-V-------------------F-----FAP-F----------P-LLPKRVL-MNRTFICCVIIDFIYQMAG-YFSLLFFTSYTFVVLNLSYRDWVYLSNTTTMGLCL-FGVVWGALFR-C---------FHRY-KIFQVVGIAI-KLIGMGLY--VACSKR----------------------------DG--S------PGI--GLVVAALVVTNFGDAANVM-GTQVAAQAAVP-HQ------DMAATISVLSLYSSIGAAVGTAITSAV-W--TDKL-PGALSKYVPD---------------------KEKAAAFFESLTSIWE------------EPWGSVNREGAINA-YQKVNYTLFCMGLGVSSIMFIV--ALFQTN---Y---YL-----GDQ--------------------------------------QNCVEGEQKEDYHHNANGSKKTLLNRAFDFWK---------------------------------------------------------------------------- Saccharomyces_kudriavzevii_IFO_1802_saku_c1886.4 --------------------------------------------------------------------------------------------------------------MSGVVSITDSISGKLNVQEKYHEEAKSDAAEKNLVSIDGSLKQITSATSCYDG----------------------------------------------------------------------------------------------------EKIIKTRGVTRIEVVREKMSTRVRWILGLSIFLTSAVAALDATTTYNYQPYATSSFN------RHSM--LSTLTIANSVIGAVCKPFIAKISDL-SSRPVTYFVVLLLYVIGFVITACSP-----TIAAYVVGSVFIAIGQSGISLMNMVIIADTTTLK--WRSFFTSLLSVPYLVTT-WISGYIVEDIINS---------NWRW-GYGMFAIITPVALTPAILVMAYL-------EHQ----------AN-------------------------------------KTGEIPVGSDPLSKKRIEVTESHVSGFRE--------------------YWELV--------KV--------SL-----------IEI----DAFGLILLGFAFSLILLPCSLYSY------AEG----GWNN------PSMIAMEVVGGIF-L-ISYVV--FE-V-------------------F-----FAP-F----------P-LLPKRVL-MNRTFICCVIIDFIYQMAG-YFSLLFFTSYTFVVLNLSYRNWVYLSNTTTMGLCF-FGVVWGALFR-G---------FHRY-KIFQVVGIAI-KLIGMGLY----VTCS----------------------------KK--E------GSPGIGLVVAALVVTNFGDAANVM-GTQVAAQAAVP-HQ------DMAATISVLSLYSSIGAAVGTAITSAI-W--TDRL-PGALSKYVPD---------------------REKAAAFFESLTTVWE------------EPWGSANREGAIDA-YQEVNYTLFCMGLGVSAIMFIV--ALFQTN---Y---YL-----GDQ--------------------------------------QNCVEGEQREDYHHNADGSKKTLLNRAFDFWK---------------------------------------------------------------------------- 'Saccharomyces paradoxus NRRL Y-17217 sapa c345 7143' --------------------------------------------------------------------------------------------------------------MSGVVSITDSTSGQLNADEKSRGNARNDAAEKDLVSINGGLQQVSSSTSSCNG----------------------------------------------------------------------------------------------------EKIIKTRGVTRIEVVREKMSTKVTWILGLSILLTSWVAALDATTTYNYQPYATSSFN------RHSM--LSTLTIANSVIGAVCKPFIAKISDL-SSRPVTYFVVLLLYVIGFVITACSP-----TIAAYVIGSVFIAIGQSGISLMNMVIIADTTTLK--WRSFFTSLLSVPYLVTT-WISGYIVEDIINS---------NWRW-GYGMFAIITPVALTPAILVMSYL-------EHQ----------AN-------------------------------------KTGDIPVGSD-PLAKKKVEVTESHISGFKG-------------------YWELL--------KA--------SL-----------IEI----DAFGLILLGFAFSLILLPCSLYSY------AEG----GWNN------PSMIAMEVVGGIF-L-VSYVV--FE-V-------------------F-----FAP-F----------P-LLPKRVL-MNRTFICCVIIDFIYQMAG-YFSLLFFTSYTFVVLNLSYRDWVYLSNTTTMGLCF-FGVVWGALFR-G---------FHRY-KIFQVVGIAI-KLIGMGLY----VACS----------------------------KK--D------GSPGIGLVVAALVITNFGDAANVM-GTQVAAQAAVP-HQ------DMAATISVLSLYSSIGAAVGTAITSAV-W--TDKL-PGALLKYVPD---------------------KDKAVAFFESLTSIWE------------EPWGSANREGAISA-YQEVNYTLFCMGLGVSSIMFVV--ALFQTN---Y---YL-----GDQ--------------------------------------QNCVEGEQKEDYHHNANGSKKTLLNRAFDFWK---------------------------------------------------------------------------- Yarrowia_lipolytica_CLIB122_yali0a10593g -----------------------------------------------------------------------------------------------------------------------------MAILHKPSFHFQKATF--------ENPFHRSPEEKNET------------WIKYIFDPHVTVV---------------------------------------------------------TTKTHD------------HSNNKADGAKEIETIKQFMDKKMLFFAWISLMLVSTVVALERGTTSTYAAVATSHFN------ELGL--LSAVGVVRSVLYAVTRPTIAKLADV-LGRVEALVLAIIFYIIGFAMLAGGS-----NIATYFAAHIFYVSGEVGIQFMEAVFATDTSNLR--NRTFFLALPNFAYVWAS-WVSAPIASGVLKN--S------TYRW-GYGMWCIIMPVVSIPVCIILLRL-------KFK----------AR---------------------------------------AMGLEYGK---------------------------------------AVRNF--------RG--------TF-----------SQF----DMVGLILFTAGLCLLFLAVTLATS------PTS-----WGQ------AHILVMIIIGPIL-L-FIFPF--WE-I-------------------F-----GPK-Y----------P-FMPSYVI-TNRTMFTTCLLIFCYALAY-FLYGTYYLPWLMVCKNLSVKAATNTVNVFVVGSTV-SSFFAAAYAK-Y---------FKRM-KPVIIAGAAI-YMLGIGLT----YNYR----------------------------KP--T------HRL--SQFIVSQCVEAVGAGFLQT-PMISMIHAVVP-HH------NVVTATAIYQSIMTVGSIVAEAIAGTL-Y--RQSY-PKQ----LAK-----HAPFLS---------PREAHQVVNN-LMAPIK-----------LYPWGTPEREAIVTA-FNDIYRKLLYPPIIIAGFIFVA--AFTLPN---V---YL-----GDT-----------------------DEPTQSDSEVDSSSIDEKIHPHDEEAQYEQHHDMEASTSPENIPQISEGMEEEKKM------------------------------------------------------------------- Candida_dubliniensis_CD36_cadu_34690 -----------------------------------------------------------------------------------------------------------------------MNSDYTKDRKTTITFDEKQLPGTPPESITTLTDINNNNNNNNDK----------------------------------------------------------------------------------------------------EIKPQELADKLSDVHSNLLPKSQIIIILLTLSLANIVSFMDQTGITIGLSIISKDLN------AQQS--INWAGSASLLANTVCQVLFGRMSDI-FGRKKIILICLMILVIGDISCSLAR-----NGIEFFIFRALAGIGNGGVSSLSMVILSDIVSLK--DRGKYQGILGASVGIGN--AIGPFIMGAFIK-----YNNNNWR--CY--YYFLAPLGFIVNIILFFCL-------KNN--------------------------------------------------HKHKNNHKDKKLN-----------------------------------DVISR--------KE--------KF-----------LNI----DYMGILMATSSLTLILIPLNGGG-------STY----NWNS------NLVIIMFTIGGLL-L-LGFLLIEWK---------------------------FAK-L----------P-MIPLELF-KNPSLCLLYLATFCFGATY-FSFIYYLPYHFQIIKNKNEIDTAIFLLPLVLMQSI-SSIICGRIIS-Y---------TGHY-FYVVQSGYLL-WLLSVGLL-----ILW--------------------------------N------KSLSDGIHILILFIMGTGVGAAFQ-PSMVAVQANCK-KS------QRAVAISTRNVLRSLGGTVGIAIGSTI-V--SNSV-LKELTPLNNN--------NNNNPNSNSNSNSSLSPEIIKYIKNHIYE------KIPLTSLNLNNQQINEIKDI-YTIALRNYYYFLIPLMTICVIT--AMFIKD---NGLKAL-----DEQ---------------------------------------NPIDTKDFIKRKQDLESSASSMTVKCENENENENCINTTVNK----------------------------------------------------------------- Candida_guilliermondii_ATCC_6260_cagu_04002 -------------------------------------------------------------------------------------------------------------MSSEKITDSVHSISGKSIQEPAVAKSTAISTNSGSNKLESESENAQNASESETE------------LHLVSSDTSTEYVK--------------------------------------------------------------------------SRGVRRIENVKVMMSSAKNGKIITIAFCTCLLVIAWVLSLDGSTTSNYSVPATSSFS------RHSM--ISTVNIATSIIGSVVQPFQAKFSDI-TSRPICFGVSLLFYTVGTVIAASSS-----TIGAYVVGSVLTTVGSNGVSFLKDVIVADLTDLK--WRGVVNGIMTSPYLINI-WFSGLIVEAILKR---------NWRW-GYGMFAIIMPVVVLPAIGVMYHF-------ENK-------------------------------------------------AQKYVPKVVR---------------------------------------PKKTL--------QK--------II-----------WDSAIEIDALGLLLLGFGWSLLLLPFSLYTY------AQD----GWKN------PSLIAMLVVGPLL-L-IIFVF--YE-I-------------------F-----WAP-F----------P-SMPKRII-KNKTFITCIIINFIYMLAD-GIRSQYLSTIVWIAKDWSDQNWTYFNNTLTMSLCF-FGIVAGITCR-I---------THRY-KYMQSFGILI-RCVSYCLP------LR----------------------------AQ--G------TTANTGSYVMCQVLMGFGSAYSTI-GTQISSQASVP-HQ------DLSLVMSLLLLWSTVGSAIGYTISAPI-W--SSKL-PGY----LRR----------------FIPDTYSDEEVFGF-YSDVSS-------LR--ALPYDSDARQGAIKA-YSYVAVYMFAPPIALEFLNFLI--SFMQTN---Y---YL-----GDT------------------------------------------HNAIEGQNGKDPTKPDQEKYEPKTTKEKILYLFR---------------------------------------------------------------------- 'Saccharomyces bayanus 623-6C saba a 601.3' --------------------------------------------------------------------------------------------------------------MSDLISIAESTIGRLNAQEGPYKEERNTFTEKSTVSSAHEGFQQSSSAFSSQD---------------------------------------------------------------------------------------------------GNKIIKTRGVTRIEVVKEKMSTKVTWILAASILLTAWIAALDATTTYNYQPYATSSFN------RHSM--LSTLTIANSVIGAVCKPFIAKISDL-SSRPVTYFVVLILYVIGFIITACSP-----TIAAYVVGSVFIAVGQSGINLMNMVIVADTTSLK--WRSFITSLLSVPYLVTT-WISGYIVQNIISS---------NWRW-GYGMFAIITPVALTPAILVMAYL-------EHE----------AN-------------------------------------KTGEIPIGSDPLTEKKREIRESGISGFKG--------------------YWQLL--------KT--------SL-----------IEI----DAFGLILLGFAFSLILLPCSLYSY------AEG----GWKN------PSMIAMEVIGGIF-L-ISYVI--FE-V-------------------F-----FAP-F----------P-LLPKRVL-VNRTFICCVVIDFIYQMGG-YFSLLFFTSYTFVVLNLSYKNWVYLSNTTTMGLCF-FGVVWGVLFR-Y---------FHRY-KIFQVVGIAI-KLIGMGLY----VACS----------------------------KK--D------GSPGIGLIVAALIVTNFGDAANVM-GTQVAAQAAVP-HQ------DMAATISVLSLYSSIGAAVGTAITSAV-W--TNEL-PGALLKYVPD-------------------------KEKAITFFESLT------LIW--QEPWGSENREGAIAA-YQEVNYTLFCMGLGVSSIMFIV--ALFQTN---F---YL-----GDQ--------------------------------------QNCVEGEQKEDYHHNANGTEMTLMNRVFDFWK---------------------------------------------------------------------------- Saccharomyces_bayanus_MCYC_623_saba_b_c68_15461 --------------------------------------------------------------------------------------------------------------MSDLISIAESTIGRLNAQEGPYKEERNTFTEKSTVSSAHEGFQQSSSAFSSQD---------------------------------------------------------------------------------------------------GNKIIKTRGVTRIEVVKEKMSTKVTWILAASILLTAWIAALDATTTYNYQPYATSSFN------RHSM--LSTLTIANSVIGAVCKPFIAKISDL-SSRPVTYFVVLILYVIGFIITACSP-----TIAAYVVGSVFIAVGQSGINLMNMVIVADTTSLK--WRSFITSLLSVPYLVTT-WISGYIVQNIISS---------NWRW-GYGMFAIITPVALTPAILVMAYL-------EHE----------AN-------------------------------------KTGEIPIGSDPLTEKKREIRESGISGFKG--------------------YWQLL--------KT--------SL-----------IEI----DAFGLILLGFAFSLILLPCSLYSY------AEG----GWKN------PSMIAMEVIGGIF-L-ISYVI--FE-V-------------------F-----FAP-F----------P-LLPKRVL-VNRTFICCVVIDFIYQMGG-YFSLLFFTSYTFVVLNLSYKNWVYLSNTTTMGLCF-FGVVWGVLFR-Y---------FHRY-KIFQVVGIAI-KLIGMGLY--VACSKK----------------------------DG--S------PGI--GLIVAALIVTNFGDAANVM-GTQVAAQAAVP-HQ------DMAATISVLSLYSSIGAAVGTAITSAV-W--TNEL-PGALLKYVPD-------------------------KEKAITFFESLT------LIW--QEPWGSENREGAIAA-YQEVNYTLFCMGLGVSSIMFIV--ALFQTN---F---YL-----GDQ--------------------------------QNCVEGEQ-------KEDYHHNANGTEMTLMNRVFDFWK--------------------------------------------------------------------------- Saccharomyces_cerevisiae_S288C_sace0h00198g ----------------------------------------------------------------------------------------------------------------------MIEVPEDNRSSQTKRKNTEKNCNELMVDEKMDDDSSPRDEMKDKL----------------------------------------------------------------------------------------------------KGTKSLIIRKSELMAKKYDTWQLKAIFLFSAFICTFAYGLDSSIRGTYMTYAMNSYS------AHSL--ISTVSVIVLMISAVSQVIFGGLSDI-FGRLTLFLVSIVLYIVGTIIQSQAY-----DVQRYAAGAVFYYVGLVGVMLQVVLMLSDNSSLK--WRLFYTLIPSWPSIITT-WVSGSVVEAANPL--E------NWSW-NIAMWAFIFPLCCIPLILCMLHM-------RWK----------VR-------------------------------------NDVEWKELQDEKSYYQTHG------------------------------LVQML--------VQ--------LF-----------WKL----DVVGVLLFTAGVGCILVPLTLAGG------VST----NWRN------SKIIGPFVLGFVL-V-PGFIY--WE-S-------------------R-----LAL-V----------P-FAPFKLL-KDRGVWAPLGIMFFICFVY-QMAAGYLYTILVVAVDESASSATRIINLYSFVTAV-VAPFLGLIVT-R---------SSRL-KSYIIFGGSL-YFITMGLF----YRYR----------------------------SG--Q------DAD--GGIIAGMVIWGLSSCLFDY-PTIVSIQSVTS-HE------NMATVTALNYTVFRIGGAVAAAISGAI-W--TQSL-YPKLLHYMGD------------------------ADLATAAYGSPLT------FIL--SNPWGTPVRSAMVEA-YRHVQKYEVIVALVFSAPMFLL--TFCVRD---P---RL-----TED---------------------------------------FAQKLPDREYVQTKEDDPINDWIAKRFAKALGGHKKDLQNPNRICVRKNDL-------------------------------------------------------- 'Candida tropicalis MYA-3404 catr 03958' ------------------------------------------------------------------------------------------------------------------------MLPTVDKDISKESVSIIERVSSEDFYPSDQANKLEKQSSIQSI----------------------------------------------------------------------------------------------------HIFRESDAGDGTSKEDHYLQGSQLILCFFALSSALFLFSLDQTIIATILTTVGSKFN------SFEE--IGWLSSAFMLGMAVFIQPFGKLSII-LGRKWTMVVAILIFQGGSLMCALAN-----SMNVLIGGRVMAGIGGAGVNSGVFVIVSEVVPIN--KRPMALSLLGIIFAIAS--VLGPLIGGAFTS--N--V---TWRW-AF---YLNLPIGGVSLAVFIFTF-------HPP-----------K--------------------------------------------------------------------------------------PKVNI--------KQ--------EL-----------LRF----DYLGTFLLISGWVVFLLALTFGT-------SEF----AWNS------SAVISCFVIGPVL-L-IAFGI--WN-F-------------------G-----FSK-N----------Q-ILATEVI-VIPQVLASVVSLSGIFAAY-IMIMIYGSIYFQLIKDSSPLGAGLHLLPLVISVSV-SILFTGSMTQ-R---------LKYL-KPYIIVAGVC-GVVGCALL-----TLL----------------------------EV--D------SNF--GQEIGLFILVGVSMGLTMP-PSLLTAQVKAP-KTPS----GMINTTVFMNFSRSISSAFGAILGDAV-Y--SVSL-KKRYKYAIKG---------LNNPQ-----IIQELEKFDIKHLISSTA------EIK----SLSPDTQHFVKTQ-IMYAIRNVFYTTIGFAAISCIA--GVFVTN---K---KL-----PEE-----------------VEIKPKNLEPENKKVQDLSKNEIMVVSEELDTANSDQSEPIQSPQKVKKKVHRDIVEERMLYLLTIGKR------------------------------------------------------------ Yarrowia_lipolytica_CLIB122_yali0d05401g ------------------------------------------------------------------------------------------------------------MNLEELDKKAKYVFDTKDRVAEKFFESLPPKTRGLMKFLFSPDHDYDSAIEHFDD----------------------------------------------------------------------------------------------------TSSTDDIQLTHAEIVRRVWSKKQLIFGWICMLIMSLVSTIQASAFPSYIVYASSEFS------QMGA--LASVQIVQACIFLVSRALSGKLADN-FGRFEAMIISVICLTIGNGLYMGSH-----NIVTYFAALAFYSIGDIGTQMLYEIFAADTCDLK--DRTFFQTITLFANLFTP-WVAGPLVASVLKT--S------TWQW-GMGMWAIITPCCAIPFLSTLLYF-------RIK----------AY-------------------------------------RMGLRIRRGDPNRT-----------------------------------WFQNT--------IT--------GI-----------IRM----DLPGLVFLCAGLILFFVPISFCVG------TDD-----WKM------PQNIAMITCGTFF-LYVAFPL--WE-F-------------------F-----GTK-H----------P-FLKFSLM-KKRLVTVPGLIILLYYMAY-ATYHPYFQVWLLLAKGLPQARATNLNMAMFVALTG-TTLVFSPLMR-W---------RAKL-KSVIVWGTIL-YFIGMGLT----YEFR----------------------------KP--E------KPL--NTMILAQIFEGVGAGLLVI-PIMVYIQVVCK-QS------DTAAAITIYYFFNSCGTILGNVISAAV-Y--RNHF-PNV----LRK---------------TGLFAEPEVKAIFGSIYVGLSY-------------KVGTPQRAAIGAT-LNSVIRSLLIGPLIFCAIMFCL--AITNADINLNTAQRM-----KEE--------------------------------SEHVKGDDSQSSDQGVVIETAYEEKSPIYDEKKVTEVVNKA------------------------------------------------------------------------- Yarrowia_lipolytica_CLIB122_yali0d20350g ------------------------------------------------------------------------------------------------------------MNLKELDEKAKYVFDTKDRVADKFFESMSPKPRKLMKFLFSPDYDYSSATENFDP----------------------------------------------------------------------------------------------------NDTVDDLQLTHSEIVRKVWNKKQLIMGWGFLLFMSLVSTIMSSSFPSYIVYASSEFS------QMGA--LASVQIVQSCIFLIARALCGKLADN-FGRFEAMFISVCSLTVGCGLYMGTH-----NIVTYFAALAFYSIGDIGIQMMYEIFAADTCDLR--DRTFFQTITLFANLFTP-WIAGPMVQSMLQH--S------TWQW-GMGMWAIIVPVCSIPFLVTLLYF-------RIK----------AY-------------------------------------KMGLRIRRGDPNRT-----------------------------------WWQNT--------IT--------GI-----------IRM----DLPGLCFLCAGLILFFVPISFCAG------TDN-----WKQ------PGNIAMLTVGTFL-LYVAFPL--WE-F-------------------F-----VTK-H----------P-FLKYKLM-SKRLVTIPGFIILFYNMSF-AIYHPYFQVWLLLAKGLKQAKATNLHMAMFVSLTG-TTLLFSPLMR-W---------RAKL-KSVMVWGTIL-YFIGMGLT----YEFR----------------------------KP--E------KPL--HTMILAQVFEGVGAGLLVI-PVMVYIQVVCK-QS------DAAAAITVYYFFNSTGTILGNVISAAV-Y--RNHF-PKL----LRE-------------------TGSFTDREIQAIFGSIYA------GLR---YPVGSPQRAAIGTS-LNTVIRSLLIGPLILCAIMFCL--SLTNADINLDTAQRI-----KEE--------------------------------SEHVKADESTDDNGLVVETDSIEKPPSYDEKKQVEEMVQKA------------------------------------------------------------------------- Candida_lusitaniae_ATCC_42720_calu_01670 -------------------------------------------------------------------------------------------------------------------------MSVPDEKRVHGSDASDQYNSEDKSYSEDNVAPAPNYTNLAAH----------------------------------------------------------------------------------------------------STAKSFGIRKAEIMADQMSGFIPKAIFYFCAFCCSYCYALDGTLRSTFQTYATSSYS------NHSL--FTTVNVIRSVMAAASQPAYARLSDI-FGRLELFIVSIIFYAVGTVIESQAF-----DVQRFAGGAVLYQLGYSGVQLILEVSLSDMSTMN--WRLFASFVPALPFIINT-WISGNASSELLAH--H------SWSY-SIGIWAFIFPLASVPLLACFIYM-------RFK----------AG-------------------------------------RTPEWAAIRQEEKEAYKG-------------------------------AKHFF--------ID--------LF-----------WRI----DLIGILFIICVFGFILVPFTIAGG------VHT----KWQR------GSTIAPLVIGFVL-I-PFFVY--WE-Y-------------------K-----VAK-Y----------P-IVPYPLL-KDRGVWSALIIACLVNFIW-YMPNDFMYTVLIVGMRASIKAATRITSLYSFVSVI-TGPLLGLVIV-R---------VKRT-KPFIIFGCTT-WMVAMGIL----YHFR----------------------------GD--NDGVNSQKYL--NGVIGGLCLMGFGAGFFTY-TTQVSIQTCTN-HE------YMAVVLSLYLAAYNVGSAMGTSVSGVI-W--NQLM-YKAMVKNMRK--------------------LGVDTALATTAYSDPYT------FII--TNVWGTDARIAVVLS-YAEIQRKLCIVGLCLCVLLIVF--AFFLRD---H---RL-----EAV--------------------------------QSLDEAHDPSQGVHVQKELLDDTVVVNNYDKDPIANFFKGIFKRNSV------------------------------------------------------------------- Candida_parapsilosis_CDC_317_capa_03962 --------------------------------------------------------------------------------------------------------------------MSKKQVNSATSSVKSTDFSGLPQPFTNGNTDDIPQPSQQQQPQQPQQ------------LPEDLEDQSSVGSRHG-------------------------------------------------------------------------HFKESDAGDGTLREDQYIHGPRLALCFVSLFLCLFLFALDQTIVATILSTVGNKFD------AFEN--VGWLSSGFLLTMAVFIQPYGKLSII-FGRKWSMVVAIVIFEAGSLMCALAS-----SMNVLIGGRVLAGVGGAGIQGLAFVILSEVVPID--KRPLGMTILSVTFAVAS--VLGPLIGGAFTT--H--V---TWRW-SF---YINLPVGGFALAVFLYSF-------RPP-----------L--------------------------------------------------------------------------------------PKVDI--------WE--------EL-----------KQF----DYIGTFFFISGSVILLLAITFGS-------SDF----PWNS------GAVISCFVLGPVL-L-IIFAI--WN-F-------------------R-----FSK-N----------Q-IIGTDVI-TTPQIIASALSISGVYSAS-IVTMIYASVYFQVIRDSSAMGAGLHLLPSIIATVI-SSIVAGGAIQ-K---------LKYV-KPWGVFSGVL-APIGAGLL-----SLL----------------------------RV--D------SPF--SKQVGLLIIMGAATGSQFQ-PAMLSAQIKAP-KTPG----GTIMTTTFINASRCLSSAIAATLSDAV-Y--TSSL-NNF----FKK-----NIPKAS-AE----VQQSLQSIDISN-LMSNNA------ILR----TLDPATEKFIKEQ-MMKSIQNVFYMCIGLAAITTLA--CPFVSN---K---KL-----PDT-------------KQVA---------------KVEKKKEEIEQGDATEAEKEAQMKELDAELTDSTPQDLPNESNKVETK------------------------------------------------------------------ Kluyveromyces_lactis_CLIB210_klla0e14609g ----------------------------------------------------------------------------------------------------------------------MDQSDMKVNMDRKIQSRSSSFDNNEDSFPNANKENLTFAEENHKQ------------ELLDEYGVPDKL----------------------------------------------------------------------------RANRSLVIRKMEIMRKQYTSVFAICVFLFTAFLAGVGTDLNSQLRNNYTTYATNSYR------SHSL--LSTIGVVSSIISAGALTVYARLSDV-FGRIRLYLSAMLFFVVGTIIQSQAN-----NVQKYAAGTVFYSLGTAGIQVMMFIIMSDFSSLK--WRLFFTFAPTWPNLFIP-WITGSIVDRLDPV--E------RWSW-GIGMWAFIYPLSSVPFVAYLLLV-------RYK----------AS-------------------------------------KTEEWKMLSSEKTYYETHG------------------------------IIQTL--------VQ--------LF-----------WKV----DVVGLLLFVAFLGCILVPLTLAGG------VSS----QWSN------GKILGPFILGFCL-V-PAFIL--WE-T-------------------K-----YAR-L----------P-IAPFKML-KDRGIWSALIISMLAKTVY-YLAAGYLLTILMVAVNQSRGMAAVIMNVWSVVGCG-FSPFFSYFVV-R---------VRRL-KPFIIIGCGI-WMVSMGLL----YYYR----------------------------SG--E------HSK--GGIIGAMVLWGLGSTMITR-TTVISSQSITA-HE------NMATITAIMLAISRIGGGIGSAVSGAI-W--TQTL-YAKLVETIGD------------------------PEIAKKVYQSPLS------AIR--VYAWGTPTRDAIVEA-YRHVQRFEVLVAMILVIPLFIA--SLCLRD---P---EL-----TDE--------------------------------------VAHTDIKDGEFIAVDGNDAIANWFSNKWENIKLRRRSHSDE------------------------------------------------------------------- Pichia_pastoris_GS115_pipa_2g00050 -----------------------------------------------------------------------------------------------------------------------------------------MKFNIFNKNRKESPSSSPESQTTDEE----------------------------------------------------------------------------------------------------AHIPVLPGVARAEMLRHAWSKKSLIVAYAALFFAAFVFQFCGVTVKSYTPYATSSFR------QHSM--LTTAAVVYKIVCVITLPFVARIADC-FSRVSGFFIALIFLIATYIMFAASK-----NVGMYLASEIFLGIGKVSYVMMEKVFVADTTQIL--NRGLWTALPTAVASIPTLYISSIVAEKVLDH--S------TWRW-GYGMWAIITPVSLAPLIFIMWRL-------DRK----------AQ-------------------------------------KYGITHNIKASLNLPEGS-------------------------------WYKKL--------AH-------LLY-----------VEL----DIVGGLLMLAGLSLFFLPFTLTGS-----ASIL----DWDE------ATTIVLLVLGFVV-L-GIFVF--WVLS-------------------K-----FPQ-R----------P-FISVSIL-KNPSVLMACTLPLFDTINS-STSGAYYSSVLQVSGHFTVGEAARITRASRVCQLV-GSVLVGILIK-----------YTRTAKIFMISGISL-IVITQGFF-----CYL----------------------------SDHNG------QFGSELHWTVIQVFEGFGRGFYNI-PTIISVQANSD-PS------QIAPSIAMFTMFSQMGAVIGNSIAASV-W--NELV-IKRLTQYLPE-------------------GSKSSATSIFGSIKVALG------------YKQGTPEREAIDRA-YREVLQKQGYISLGFLLPALII--VFFIKGFDPTQRTSVNVDDNGEV------------------------------VLRTATGKNGEGPQFHTISSNLSSSSSASDLSEEKDGTSAASKEKNSLSTEPERK------------------------------------------------------------- Candida_parapsilosis_CDC_317_capa_00064 --------------------------------------------------------------------------------------------------------------------------MDRTEPTKVESYDEIEKDNKTYSGDEGETATQLNAEKEALN----------------------------------------------------------------------------------------------------TTTKSIGIRRAEILQLQYQNPVLRVLFFFCIFLVAYGYGLDSTVRGNLQYYATSSYS------QHSL--FTTVNVMQSVISAAAQPFYARLSDK-FGRLELCLFAIVFYSMGTVIQSQAY-----DINRFAGGSVIYQIGYTGIVIMLQIILADFSNLN--WRLLCSFIPALPFIINT-WVGGDVVSSVLAH--Y------SWNW-GIGMWAFIFPLSFVPLLCCFIHM-------HIK----------AR-------------------------------------KTPEWQALTREHNSQRYSKTSFAY-------------------------WKKLI--------VG--------LF-----------WDL----DVIGLLNVIIILGFILVPFTLAGG------VSS----KWAR------ASTIVPLVIGVVF-I-PIFVI--WE-A-------------------K-----FAR-S----------P-IMPLPLM-KDRGVWAALLIAIFINWIW-YMPNDFMYTVLIVGMNASVKAATRITSLYSFVSVI-VGPILGLVVV-R---------VRRL-KGFIIFGCVC-WAVSLGIL----FHFR----------------------------GA--NDGVESQKYL--DGVIGGLCLMGFGAGFFTY-STQVSISTVTN-HE------YMSVIISVYLASYWIGSSLGTSISGAI-W--TNRM-HGVILDKMQE------------------MNIANATELASSAYNAPFE------FII--ENTWGSPARIAVVTA-YAQVQRYLCIAGLVLCFPLIMI--TFLLRD---H---RL-----DSV--------------------------------QSLEMDHDHEKGVVKDGKVVVNNYDDDVLFTKLKSLFNIGKR------------------------------------------------------------------------ Pichia_pastoris_GS115_pipa_3g01745 -------------------------------------------------------------------------------------------------------------------------------MKFNVFRKSQNESA--------SGSPESQNTDTEAQ----------------------------------------------------------------------------------------------------THVTLLPGVARAELLRHAWSKKTLIIAYAALFFVAFVIQFCGVASRAYTPYATSSFR------QHSM--LTTATVVYKIVCVISLPWVARIVDC-FSRVTGFFIALVFLIATYVMFAASK-----NVGMYLASQIFLGIGIPSYVMMERVFIADTTQIL--NRGLWTALPTAVASIPTLYVASIVAEKMLEH--S------TWRW-GYGMWAIIIPVSLAPLILIMWKL-------DRR----------AK-------------------------------------RYGVTHNIKSTLNLPEGS-------------------------------WYKKV--------AH-------LLY-----------VEL----DIVGGLLMLTGLSLFFLPFTLTGS-----ASIL----RWNE------ATTIVLLVIGFLI-L-VLFVL--WVLS-------------------K-----FPK-R----------P-FLSVSIL-KRPSVLMACTLPLFDAINT-SLSGAYFPSVLQVSGHFTVGEAARIPRAANVCQMV-GAVLVGLLIK-Y---------TKTA-KVFMVSGVCL-IVLTQGFF-----CYL----------------------------ANNNG------GFGSELHWTVIKVFEGFGRGFYNI-PTIISVQANSD-PS------QIAPSIAMFTMFNQMGAVIGNSISASV-W--NELV-IKR----LTQ--------------YLPEASKSRAREIFGN-IRVAIG------------YAEGTPEREAIDRA-YREVLQKQGYISLGFLIPALIL--VFFIKG---F---DP-----TQR----------------------------TS--VNVGDDGEVVLTSAPGKDGEAQLNTIAANLSSSPSNSDISEERESSEITSQEKKSELNESEAK--------------------------------------------------- Yarrowia_lipolytica_CLIB122_yali0a14883g -----------------------------------------------------------------------------------------------------------------------MWAPIKHALYAPKPEPGSSPTVVENPSTFQKIFNPPVKKDENAI----------------------------------------------------------------------------------------------------DENAAPNGSQEMAKITSLWNRHDLWMAWGSMLLIAVALALQGRTFKVYSTFATSEFE------ELSL--LSSLAVTQAVINVAATTVFAKLADV-LGRFESFLLSVVFFTIGFIMLAVSP-----NIGTYFAAHIFYVSGSQGITFLQQVFAADTSSLR--NRLFFVVLPNVCYIFVP-WCAAPITNAIIKH--S------TWRW-GYGMWCIIVPIVSIPVLTILFRL-------KMK----------AK-------------------------------------SLNMAGGKSL---------------------------------------QVRDA--------KE--------TL-----------RQF----DFIGLTLLTAGLALLFLAVTLVK-------TSK----SWTE------PHVLVMVIIGPIL-L-VLFPI--WE---------------------K-----FPK-Y----------P-FLPMKNM-KNRTLITGCVFAGIHAMAT-SLYNPYYMPWLLVCKGLSVTAATNASATLSVSYIV-TTIIAAFIIR-Y---------TRRV-KPCIVAGSCI-YTLGLGLT----YHYR----------------------------QP--D------VPL--AKFIVTQAVEGVGNGLLQS-PALVLTQSSMP-KH------LVISATAIYYTINSIGRVVGDAISGSL-Y--RQQY-PKRLAEFAPF------------------MDEKTVQRMVND-VNSPLK------------FAWGSEERVAVIEA-FNHVYRKMLYGPMIIAAVGILI--ALTFPN---INMSEV-----DNG------------------------------FVVEETEEDMPATAVVNEKKQQQPSETSESETEKKLPEVSSSHTVSSGPRSADLSVEEHERRV----------------------------------------------------- Kluyveromyces_polysporus_DSM_70294_klpo_543.44 ------------------------------------------------------------------------------------------------------------------MGKKDKQRKKLRNFTKAKVKQVQEDQEPMVPDPPEFDGTESFVQTLAET------------SQLTKEDDENSVLLPIRDELLQDPSTELPGFIAAEIEEGEQEYEETRS----------------------------------------GHYGAIESRRISSKGTELSTAR-LKIIMLSMYLGIFLAALDNTIVSTLLAHIASEFN------ELPR--ISWVATAYLLSSATFQPIYGKISDI-FGRKVVLIFCNITFFVGSLICGLSP-----SFEWLVAGRFIAGIGGGGITSMSSITTSDIVPLR--NRALYQGICNFYFGLGT--ALGGVVGGWFSD-RS--V---GWRM-SF---LIQLPIAFFSTILIILFL-------RLP-------------------------------------------------KESKGRGLQVDGN------------------------------------YFSTI--------KV--------RL-----------SAV----DWIGATTLVLFLFSFMITASLGG-------KEI----PYTS------HKFIGLCVVTVIG-A-LIFGY--TE-L-------------------K-----IAK-D----------P-ILPLRFL-KDRSVLGSSLSNWFCMMAL-MTVSYYLPIYFAGVLNMKPTDIGKRIIPNFFSTAF-GSLGAGYYMK-K---------TGKY-YWFVISFCVL-ASIGCLQI-----VWI----------------------------QP--D------ISV--FKQYTLMFIPGLGASVLIT-VALLAMIAAVP-HN------HQAVTTSISYAFRSTGCTLGVSIGGAI-F--RESL-DNL----LKS-----KVLKFKSPE----HSEDELMRIIDK-ASQSTE------WVQ---NSSPSFIKQTLIDC-YHFACKNVFIFCLLCTIAATFS--MAIIKE---H---RL-----HNT-----------------------------------------------LDRDNENEE------------------------------------------------------------------------------------------ Kluyveromyces_lactis_CLIB210_klla0d19945g -----------------------------------------------------------------------------------------------------------------------MNQPAVSPEWEQCEYDKDSETDKRSCKKEQGIIHDIEKMTVVEE------------TQPVGPNLEITA----------------------------------------------------------------------------RFSTKRKMKELEIVSSFCKEWHFQSILLVTAIVCGFSYNLDAVLRSTYTGYATNSFS------QHSL--LATINVINSVVSIASQLFFARLSDH-FGRLQLFGFCTLMYIVGTILQSQSK-----NVSIYAGGAVFYNAGYTGVRLLMTIMMSDFSTLG--WRYFMIASPDWCYIIIT-WVSGNIIEISNPL--E------NWSW-DIAMWAFIFPLTTIPLVGFLVYM-------FYK----------AS-------------------------------------RTDEWKELRSVTKKMP---------------------------------TPVYI--------KE--------VF-----------WNL----DIPGVLLIAISLGCILIPLTVSGG------ETE----EWKD------SRNIGVLCLGSVL-F-PIFLL--WE-G-------------------K-----IAK-R----------P-VLALTYL-KDRGVWAPLAASFFMSNAY-LIATDYLYAVLLVGFNQSESASQRITWLPSFAGVV-ITPFTGLLIT-R---------WKHL-KVLTITGCIF-YYIAFGLF----YRYR----------------------------GG--S------TNV--AGIIVGTIFMGFGSGISTY-PLMVSLQAVSS-HT------KIAIVTALFYTFEQVGRAVGSSISGAI-W--TQVM-FKEISKRLPE-----------------------EPEVALAAYASPYT------FVT--KYGWETSQRMAVVGA-YMHVQKILLLVALLMLCPLFLM--AIMMRD---A---EL-----STS-------------------------------------DVALSSSDDSHVIISKHEDKIYEAFCKFFSFSTKKEGSRERSWIWKSKS------------------------------------------------------------ Yarrowia_lipolytica_CLIB122_yali0d22913g -------------------------------------------------------------------------------------------------------------------MQESQEYLDLDPGSEKIGDTPSPDIARDLEEQAEKAAESAVDGQRADSLHRHNSYPIPPLAGLTLQRTLTHRSRVSRLSHHSEEQSGDQSG---------------------------------------------------------NAMNSETPALPGHVTQDHLSQTRRYLICFMLCVCTLLVAIDETIITTALPEIVAALK------SSSG--YTWIGTSYLLACASSMPAYGALADI-FGRKPIILLSIALFLIGSAIAGAAT-----DMGMMISGRVIQGIGGGGISNLVNVIVADIIDLK--YRGTFMGAIGATWAVGG--CMGPLLGGAFAS--G--G---QWRW-CF---FLNLPIAGVCFIFMAWLA-------NIK-----------S--------------------------------------------------------------------------------------PPTTL--------RD--------GL-----------KRI----DFLGIILITCATVCLFLALDWGG-------VHF----AWNS------APVIVCLVLSGVL-Y-IAFVL--CE-K-------------------Y-----IPN-E----------P-VMPPRLF-TNFSRTGALLCTFFHSTTF-MAVSYFTPFMYQSVYNKSPIGAAVYLLPQAIVMGL-ASAISGYIIT-K---------TGKY-KIIMIVGFSL-AAIFNGMI-----VTL----------------------------NP--D------SNT--AKQIMWVTVWGIGIGPNFE-STLIALHTHIK-SQ------DIATATSTWGFLRTIGFSIGIAIGGVV-F--QNKM--QTENEELGH------------------LLPADLRELLTGADAAAST---------TLIKNYSEPVQKVAKLM-YSRSFKDMFWTCLGLC-LGYLF--VFLIKE---R---PLEMKDAKGE-----------------------------------------------TTETEDEVDQIVDVIVDDFEGNQKHRDGA---------------------------------------------------------------------- Candida_glabrata_CBS138_cagl0e04092g --------------------------------------------------------------------------------------------------------------------MKDSDMTNMEEIQRNNSYPSNSDKDYEDEKGSGSPVINEFSKVDQIS------------TAQSEMDEKMAEQTEQQRTM--------------------------------------------------------------------TGVKNIIIRKTEIMAEVYDKWYYHAILLFTAFVCGYGYGLDGNTRYIYTGYATSSYA------QHSL--LSTINVINAVISAASQIVYARLSDV-YGRFALFCVSIVLYSVGTIIQSQAY-----DVQRYAAGSIFYNTGYVGVILVLLLILSDFSSLR--WRLVYQFVPTWPFIINT-WISGNVTSRANPL--K------NWSW-DIGMWAFIFPLSCVPLLCVMIHM-------WWL----------AR-------------------------------------KTEEWQELSKEKTFYQKHG------------------------------LKDTI--------VE--------LF-----------WKI----DAMGVFIMTISLGCILVPLTLAGG------TKS----KWNN------SHVIGPFVLGFVL-I-PILVL--WE-Y-------------------K-----FAR-D----------P-IIPYKLV-KDRGVWASFAISFLIDFIY-YMAADYLYTVLIVGVNESVKSATRISSLSTFVSTV-GSPIFSLLIT-R---------FSRL-KPFIICGCGL-WMLAMGLL----YHYR----------------------------GG--A------ESH--SGIIGALCVWGVGTTLFTY-PVNVSVQAATS-HE------HMATVTALNYTFYRIGSAVGAAVSGAI-W--TQTL-YKQLLKRVGD------------------------AALATEAYASPYK------FIV--TYTWDTPERQAVVQA-YRYVQRLETIVALVFCAPLLIF--SLCLRD---A---RL-----TDK--------------------------------------VAHDNIAEGEYVDAKDDDPIYEWFKGATTRFRRKSKE----------------------------------------------------------------------- Candida_guilliermondii_ATCC_6260_cagu_05301 ---------------------------------------------------------------------------------------------------------------------------MSNLEHTDSGSDKRTGSFDANKDQLDNRVPYIDPNSTVAK----------------------------------------------------------------------------------------------------STTKSIGIRKAEALADQYTHPVLRIILFVSIFCASYCYSLDGTLRYTFQGYATASYS------SHSL--LATVNVIRAVVAAAAQPTYARLSDV-FGRLELLVISILFYAMGTVIESQAF-----DINRFAGGAVLYQIGYSGVIVMFQIILADFSNMN--WRMAASFIPGLPFIINT-WVSGNVSSELLAA--H------SWSY-SIGIWAFIFPLSCVPILCCFVHM-------YLR----------AR-------------------------------------KTPEWALLKEEEREIRRQFQGS---------------------------WFKRM--------WS----HLVFLF-----------WHL----DVIGILFIICIFGFILVPFTIAGG------VSE----TWKE------GKIIAPLVIGFVL-I-PFFLL--WQ-G-------------------K-----FAK-H----------P-VLPLKLV-KDRGVWSSLIVGIFINFVW-YMPNDFMYTVLVVGMRASVKAATRITSLYSFVSVI-TGTIVGLVVV-F---------FRRV-KPFIIFGVCM-WFIAMGLL----LHYR----------------------------GD--NDGIQSEKYL--NGVIGSLCLMGFGAGFFTY-ATQVSIAACTN-HE------YMAIVISIYLASYNIGSAFGSSVSGAM-W--SNLM-LKQIKKNFRA--------------------HGLSETVAELAYNTPYGSVGFPGFIE--QYVWGTPERVQVVLA-YAHVQRLLCIVGLCLVVPLFFA--TLCLRD---H---RL-----ESV--------------------------------QSLELEHGDEGVKDKEGEVILNDYDEDIIIKKLRGLFSRKK------------------------------------------------------------------------- Debaryomyces_hansenii_CBS767_deha2e02596g -----------------------------------------------------------------------------------------------------------------MILEKLFKVVQKMSGENYDISSINLAKLFNKSTSNQYDKEAIIDQTYAKT------------QLDENRIDAEAKVIK-------------------------------------------------------------------------DRGVYRVEASKELMDNSKNGKLMKAVLGISIVMCAWAVDLDSSVTYSLAPWATSHYQ------KHSEG-LGALTTANGIIAAISKPVYAQICNT-LSRPTTYVISVVLYTVGYIIVAASN-----TFSAYIVGLALGAAGTSGIRFINSLIAADLTVLK--WRSLATAILSAPYIINT-WYAGYIVQDLGTS---------NWRW-GYGMFTIIMPVVVCPATYILIFS-------QQK----------AH----------------------------------------KLIPEDD-RALYEQLFSFR------KN-------------------WKTFI--------WR--------LI-----------IEA----DVLGLLLLGFGFALLLLPFSLQSG------AKG----GWNN------PSMIAMMVIGGVL-V-IVFFL--WE-I-------------------L-----LAP-F----------P-ITPRRVL--NRTVICCIVIDFFYQFAG-MLPLQYLSSYVWIVQNWSNRDWTYYNNTLTVALCV-FGLVAGVLYR-V---------THRY-KVFQIFGVLL-ETVSQGFM------IN----------------------------GT--E------ARTDTLLLVWHSICSGAAGGFNVV-ASATALLAAVP-HR------DLAVAMSILSLWSLIGQSIGGAVSTAI-W--GLKM-ESE----FRK------------------YLPSSVSDEQVTGYFHSIT------AIR-EDFDWGSDERDGAIKA-YKVICYYFFAIAAALQVIRFVA--VMLQTN---Y---YL-----GDT---------------------------------QNAVEFSDETQISNEVERKNVEKSNQKWYVAIYDIW----------------------------------------------------------------------------- 'Saccharomyces paradoxus NRRL Y-17217 sapa c290 9193' ----------------------------------------------------------------------------------------------------------------MHESNSCSMKGISKTRSMSGPSYYGEKEQKQNEQQQKQKFIVSQSPTRSTS----------------------------------------------------------------------------------------------------EQDATSAPEDNPSESNELPKGFILYASLVALALSLFLAALDIMIVSTIIEEVAKQFG------SYSE--IGWLFTGYSLPNALLALIWGRIATP-IGFKETMLCAIVIFEIGSLISALAN-----SMNMLIGGRVIAGVGGCGIQSLSFVIGSTLVEES--KRGMLIAVLSCSFAIAS--VVGPFLGGVFTS--S--V---TWRW-CF---YINLPIGGLAFFLFMLFY-------NPGLHTFQETIDNIR---------------------------KIPSQLIEAVRKVKHHSLKVKELSKSNG-------------------------------WRKLA--------ME--------LV-----------FMY----DIIEFVFCSAGFTSILLAFTFGG-------NRY----AWNS------ASIIILFVIGIIL-V-ISATI--YD-FFVFPKFNIVKA--------T-----PRY-Q----------P-LMSWRNI-KKPGIFTVNIALFLLCAAY-ISQFTYIVQYFQLIYNDSAWRAAVHLVACIIPTVI-TAVLCGVLTD-K---------TRQI-KPIIVISSIL-GVIGAGIL-----TLL----------------------------NN--N------AGN--SAHIGLLILPGVAFGGLAQ-SSMLASQIQLD-KKSPTFRSDFVSITTFNTFCKNLGQALGGVISNTV-F--SAAA-VKK----LTN-----SNIELPGGN--------TVDNLVIY-RQTDFD-------------GSHSKLGNIISES-----LTHVFYMALGFYALSFIF--AVFASN---K---KV-----AAN-----------------------------------------------PRSIKNDLETGEGVGYKVAEETMSLSD------------------------------------------------------------------------ Yarrowia_lipolytica_CLIB122_yali0f19118g -------------------------------------------------------------------------------------------------------------------------MKWIGTFKNCLVGGSQQQTHDAEERGSTCGSNSVKAAPTETT------------LIKKIFNPTIVQQKDT------------------------------------------------------------------------CVDNALGGSQEMEQITSLWNKTDLWMAWASMLLVAVAVALEVQTVSVYSTFATSDFD------QMSL--LSALSVVKAVMYIATRPVMAKFADV-LGRFESILMSVVLFTIGFIMLAASP-----NIGTYFAAHIFYVFGQVGIQFMEQVFAADTSDLK--NRMFFVILPNICYLFVP-WCSAPITNAIIKH--S------TWHW-GYGMWCIIVPVVSIPVLTIMFRH-------KMK----------AR---------------------------------------ALGMQCGK---------------------------------------SVRNM--------KE--------TL-----------LQF----DLVGLILFTGGLCLLFLAVTLVKS------SKS-----WTQ------PHVLPMIIIGPIL-L-LLFPI--WE-K-------------------T-----YPK-Y----------P-FLPFSAM-KDRTLITGCIFVGLYSLAF-YIYYPYYYPWLLVCKGLSVTAATNTSVTFTVASTA-ASIGAAALIR-Y---------TKRI-KPIIVAGGFV-YILGLGLT----YHYR----------------------------QP--D------HSL--AQFIAAQAVEGVGSGMLQS-PTLVLIQSVVN-HN------QVVSATAIFYSSISVGTVIGDAISGSM-Y--RQSY-PKQLTEYAPF------------------LSEADIHKMVND-VRAPLK------------YAWGSPERVAVIEA-FNHVYRKMLYGPLVVAGVMILI--SFTMPN---VDLDEL-----EQR--------------------------------VKGVVFGKSDKPADGEKNPVSNQCPCDILPTDNSSQDGDFEKSESVVSKTIHNEQKI--------------------------------------------------------- 'Candida tropicalis MYA-3404 catr 00078' -----------------------------------------------------------------------------------------------------------------------------MSSENPILVPNEKEPEKINPELSQKDSSSSAPTTDTPS----------------------------------------------------------------------------------------------------VIRKSFGVRRVELLLRQYESIPLKILFFISVFFVCYSYSIDGVTRNNLMLYATSSYR------NHSG--FTTINVLTSVIGGISQPVYARLSDR-FGRVELLIFSIILYVVGTLIQSNAY-----GFNRFAAGSVIYQLGINGVRDMLWFVLADSTNLN--WRLVISFIPATPHLINT-WVGGDVMASVRSK--F------SWQW-GIGMYAFIFPLSCVPLLGCLTHM-------IFR----------AR-------------------------------------KHEDWKQLNREISQQFKRSN-----------------------------IGGLL--------VS--------LF-----------WEV----DLVGMILIMVSLCCILVPFTIAGG------VRT----IWQQ------ASIIAPLVIGVLL-I-PGTMI--WE-A-------------------K-----YAK-S----------P-ILPLPLM-KDRGVWASICIAMLVYWIR-DMPGEALYTVLIVGLNQSTKAATRISRLFVFVGTL-TGIGVGLVVT-K---------VRKL-KAFIVFGSFI-WFGAMGIL----VHYR----------------------------GS--SNGFNYKSAV--DGIIGGLCLLGFGSGFINF-STRVAISTVTN-HE------YMAVMISFYLASYSIGSGIGSAVVGAI-W--TQRM-YSVVLDKMND------------------LNIVDAPEKAQYVYESPFE------FIEEPENAWGEPARVAVVLA-YSQIQRILCIVGLCLVVPMLFC--ALCLRD---H---KL-----ESI------------------------------QSLEGGEAHDIEGKKVDVIVNKYDDDIILNYLKKLFGIKKKEEKKEHADEGQTQSY------------------------------------------------------------ Kluyveromyces_thermotolerans_CBS6340_klth0c10120g -------------------------------------------------------------------------------------------------------------------------------------------------MLIYLFRRLRSAAAKTRT----------------------------------------------------------------------------------------------------DTQAQTAPSHSFSLQDFSAKHALLALCLLSLVLTLFLAALDIVIVVTLYETIGEKFN------DYND--VGWLVTGYSLSSALFTLLWGRMASL-LGLKTCLMLSVLIFEIGSLIAAVSN-----SMGMLIAGRVVAGAGGSGIQSLVYIVGTSLVSER--SRGMVIMVLTFAFVGSN--AGGPILGGALNE--H--A---SWRW-CF---FINLPIGGAAAFMLFLCY-------NPS----------GK-----------------------------PLLSTLTSKLEAARDYRYSNVCTRKF-------------------------------WAHAL--------DL--------GV-----------FRF----DIIGFALSSAGFVLLLLGLTFGG-------RKY----SWSS------GTTIAYLTVGPVL-I-VVFCL--YD-FLVLPVLARSLA--------Y-----SSEVT----------P-LVPWPVI-SKPGVFATSFASFFNFFAY-NMQIIYLVQFYQVVHNESPTNASTHMWALSIPALV-VIIVLGRINK-K---------FGIL-KPVAVIGAAC-GTIGAGLL-----TLL----------------------------KG--S------TTS--GQSIGYCILAGAGFSAVMQ-STLLSAQIQVD-KTDPKFNQKFIEITTLNNFFRVLGISFGGIMGTLI-Y--STSL-KNE----LAT---------AGPNI----PSFASTDELIAY-RSKNFD-------------GASSPLENIMSKS-----IQRVFYGSLGCQALAFLF--TICMSN---K---RLDLEPNPPA------VATFEPALNAAVSDQEKGFGITQGPTSSETQNLRVSDSSLAYNITGEKADENEEHYDSMTSRDSPVSAKN---------------------------------------------------------------------- Candida_parapsilosis_CDC_317_capa_02689 ------------------------------------------------------------------------------------------------------------------------MDFIEPAKVENSKGTKQDVKTRSGDEVEVDTSSKSSEEKAPPQ----------------------------------------------------------------------------------------------------QTRKSIGIRRIEILQKQYQNPYLIIWFFFCIFLISFGYRLDAMVRGKLQYYATSSYN------KHSL--FAAVTVMQSVISAAAQPCYARLSDR-FGRLELCIFAIVFYSMGTVIQSQAY-----DINRFAGGAVIYQIGNTGISIILQVILADFSNLN--WRLVCSFVPALPLLITT-WVGGDVVASAEAH--Y------SWNW-GIGMWAFIFPLSAVPLLGCLIHM-------QIK----------AR-------------------------------------KTPEWQEMTKEINSQRKHSKKSLAY------------------------WKTLV--------TE--------LF-----------WDL----DVVGLLHVILILGLILVPFTLAGG------VTS----KWAR------ASTIVPLVIGVVL-I-PVFVM--WE-A-------------------K-----FAR-S----------P-IMPLPLM-KDRGVWSALLIAILLNWIW-YMPNDFMYTVLIVGMNASVKAATRITSSYSFVATV-VGSLLGFVVV-R---------VRRL-KGFIIFGCVC-WAVSLGIL----FHFR----------------------------GA--NDGVESQKYL--DGVIGGLCLMGFGAAFFNR-PTQVSITTVTN-HE------YMSVILSVYFASYYIGSSIGASISGAI-W--TNKM-HDVILDKMQS------------------QGVPNAVQLAKLAYEAPFK------FII--TNTWGSPARIAVVTA-YAHVQRYLCITGLVLCFPLIIL--SFVLRD---H---RL-----DSV--------------------------------QSLDMDHDQEQGVVKDGKVVVNNYDDDIILDRLKSFSTSVRARWRGSSKCTTK------------------------------------------------------------- Debaryomyces_hansenii_CBS767_deha2c05390g --------------------------------------------------------------------------------------------------------------------------------MSYSDTSSFRDTAAATGSEDFDKSSKVREHDGSED------------IPQGYNEQSIPMVVK-------------------------------------------------------------------------STSKSYGIRRSEILVEQFTHPAFSILFLFCVFICAYAYSLDGTVRFTYQGYATNSYD------QHSL--LAAINVIRSVIAAASQPTYARLSDI-FGRLELLIFSIILYAMGTVIESQAY-----DIYRFAGGSVLYQAGYSGVMLILQVILADFSNLN--WRLLCSLIPATPFIINT-WVSGNVTESALAT--Y------SWNF-CIGMWAFIFPLACIPILGCLIAM-------QVK----------AR-------------------------------------KTPEWRQIRAEEKESNRWRS-----------------------------WKDNV-------IVD--------LF-----------FKI----DVIGILFIICILGFILVPMTIAGGKTDDGAVRE----AWKE------AKIIVPLVIGFVL-I-FPFIL--WE-Y-------------------K-----FSK-Y----------P-VVPFQLM-KDRGVWSALFIAIMINFVW-YLPNDFMYPVLLVAMRASIKAGTRITSLYSFVSTI-TGVLFGLLIVPW---------ARRL-KPFIIFGGLC-WIASMAIL----YSYR----------------------------GA--NDGIESEKYL--NGVIGGLCFMGFGAGLFTY-PTQVSIQTCTN-HE------HMAIVISLYLAFYNIGSAFGSCVSGAV-W--TNTL-YKYLLDKFTE--------------------AGLDTSAAELAYGKPYD------FIA--IYTWGTPERVAVVLA-YAQTQRLLCIIGLCLSVILFIA--TFLLRD---H---KL-----ESV----------------------------------QSLELAHEEGIKAEDGEVVVNDYDNDLVFSKIKSLFKRKEKNDAI------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0h16808g -----------------------------------------------------------------------------------------------------------MARKKNSKNKQRKKLQAFVKLKERQRQLLNDEPKVVIQQNPAHSIEPTETTPFLQPIRRELVLDPTSDLPGFVAGELEEQEERCAEEQTNASGYDSIKKNTVAT----------------------------------------------------AKTIDLETSSIEAKNNTGLSPARIKIIMGSMYLGIFLASLDNTIVSTLLAHIASEFN------EMPH--ISWIATAYLLSSATFQPLYGKISDI-FGRKPLLIFSNVMFALGCLICGLSP-----GLWCLVAGRFIAGIGGGGLTSMSSITTSDIVPLR--NRALYQGICNFFFGLGT--ACGGLVGGWFSE--HGG----GWRV-AF---LIQIPLCAISCSLIVAYL-------ELP----------KG--------------------------------------CKGSGIQSD---------------------------------------EDNQI--------SE--------KL-----------RRI----DWFGALSLVVFLLLFMLASSLGG-------KEL----PFQS------NGFYALCVAIVVG-G-ATFVY--VE-T-------------------Y-----VSK-D----------P-ILPVAFL-KNRTILGSSLANWFSMMGM-MTTSYFLPVYWAGVLNMKPTDMGKRTIPSFFSTAL-GSLGAGYYMK-K---------TGKY-KWLLMAFCAL-AVVGQLQI-----SLI----------------------------EP--N------IAV--WRQYILLVIPGFGLSVLIT-VTLLAMIAAVP-HE------HQAATTSISYAFRSTGCTLGVSIGGAI-F--RKSL-GSL----LER-----NVMKLASDK----HPREELAKIIDS-AAHSSD------YIH---DSAPEFVRQALIES-YHFACRNTYKFCLASIFCALLS--CIAVKE---Y---KL-----HTS-----------------------------------------------MDRQAEEEEEEEEANST---------------------------------------------------------------------------------- Candida_guilliermondii_ATCC_6260_cagu_03941 -----------------------------------------------------------------------------------------------------------------------MASLEKQKFGKANESFIDESKIESDAIRTSKGDYSTDGSESYND---------------------------------------------------------------------------------------------------LFMEKSFGVLKEELMMAANTTYWSKGIFFFTIFIGMFVTLLETAVVSVFSSYATNDYK------QHSL--MSTVGIIRNVVAAASLPLYARASDT-FGRLEIFMFSTVMRVVGLVVMSQAT-----TIQKYAGGIVLYGLGFSGVRILWQFNLADASSLR--YRFLTLAVLHSPNIIIT-WASGDIVNGLLNR--Y------KWNF-GIALWAFTFPLACLPYFAMNIRM-------RWI----------AS-------------------------------------RTEEWAQLKHEERKSYLG----------MNESTEKHEEDIRNGNSYWSAKMKIFFIRAGYISKA--------LF-----------WKT----DLIGCLFIVLICGLILVPLTLAGG------VQT----KWTR------ASTIAQLVVGFVM-I-PFFIL--WE-R-------------------K-----FAR-F----------P-LIPFALL-TDRGIWAAFVIAVFYTFVG-GMPSTYAYPVLLVGMNATPTVATRIPQLDGFVTSL-TIPIFGVVLA-Y---------VRRS-KGFIIMGISF-WFIAMGLF----VHFR----------------------------GD--NDGLR--GKYYRDGVAAGMCVMGFGVAFISR-LVVVSAQACTS-HE------YTALIIAVFAALYQIGSALSKCVTGAI-W--TQRM-YSTIVEKMVQ--------------------LNVDPELAKPAYQAPYT------FIK--SYPWGSPARVAVVLA-YADLQRKLCITGLCLCVPTLIV--AFCLRDHYLVSTQSLEETVEPDT-----------------------------------------KGGHKTQILYKNDEDVILKYVKKCFRR------------------------------------------------------------------------------ Yarrowia_lipolytica_CLIB122_yali0a17149g --------------------------------------------------------------------------------------------------------------------MPTTTMNIEELKHKNKDTLDKLDKHAKYVFDFKDRQAEKFFGAMSPKTRSIMTFFFSPEYDYNSATETFDP----------------------------------------------------------------------------NDEVEDLQLTHSEIVRKVWSRNQLIMAWCFLIFMSLASTIMSSSFSSYIVYASSEFS------QMGA--LASVQIVQSCIFLIARALCGKLADN-FGRFEAMTISVVCLAVGSGLYMGIH-----NIVTYFAALAFYSVGDIGIQMMYEIFAADTVTLR--DRTFFQTITLIANLFTP-WVSGPMVAAVLKN--S------TWQW-GMGMWCIIVPGCSLPFLFTLLYF-------RIK----------AY-------------------------------------RMGLRIRRGDPNRT-----------------------------------WFKNT--------VT--------GI-----------IRM----DLPGLVFLCAGLILFFVPISFCTG------TDN-----WKL------GENIAMLTVGTFL-LYVVFPL--WE-F-------------------F-----FTK-H----------P-FLKYKLM-YNRFVTVPGCIIGLYNMAF-AIYHPYFQTWLLLAKGLPQARATNIHMAMFVALTG-TTLVFSPLMR-W---------RAKL-KSVLTWGTIL-YFIGMGLT----YEFR----------------------------RP--E------KPL--STMILAQVFEGVGAGLLVI-PVMVYIQVVCK-QS------DSAAAITIYYFFTSSGTILGNVISAAV-Y--RNHF-PKI----LRE---------TGLF------SEKEIQTIFSS-IYAGLG------------YKIGTPQRAAIGAS-LNTVMRSLLVGPFVLCAIMFCL--ALTNAD---I---NL-----NVA--------------------------------QRIKRASE-------QRKMDEN-EGSTEENGDAGLVVTNSFEEKSAGSSDDKKQVNEKVVQAV--------------------------------------------------- Yarrowia_lipolytica_CLIB122_yali0d20196g -------------------------------------------------------------------------------------------------------------------------MFNLNTKSSKEPEVTEVAVDSTPSSPVTRESSPESSPDNSAV----------------------------------------------------------------------------------------------------DLEKGKKSKFEMHDQTNLLPRSQLFLVFGAMAFCMLVSFMDQNGISVALPDIAKDLN------ATDT--ISWAGTSGLIANTVFQVLYGRLSDI-FGRKLVFMIVVCTLVCADIGCACAQ-----TSTQLYIFRAFSGIANGGMSCLTMIVVSDIVTLK--ERGKYQGILGACVGLGN--TIGPFLGAAFTE--N--V---SWRA-IF---YLLAPMGGLCAVVIFFIL-------PSK-----------K--------------------------------------------------------------------------------------PQGSA--------IQ--------KA-----------KAI----DYPGLFCSSVALVFLLVPIAGGG-------SYY----EWDS------PMVISMLCIGGVF-F-IAFFV--IE-G-------------------F-----FAK-L----------P-MMPLRIF-GTKALFALMMHSVLLGIAY-YGDLYYLPMYMRNIRGWSSMKAAGMSCALVTTQAV-TTVISGQYLS-R---------MGRY-LEVIYFGFGI-WTVGAIMK-----CFW----------------------------KR--D------SNM--ALLIFSLLFEGAGVGCCFQ-PTLVAAQALSR-KE------DRSVVISSRNFLRSFGGAVGLAVCSAI-L--ANSL-KAD----LKT--------------------KNLPSELYELIVKAPFS---------LPDLSHYPEYRDQVLDA-YMNGSHTVFVFLCPIVGACLLV--TVFVKD---H---GLQTHEKKAA--------------------------------EAKTVEDKDKDESGTDCEDMTKGEVLVSEKEGKLSRNSSSQSMHFGDHTAVNTPAPTGYNTPVVGTLCHNSPNFPPMDHNDVITPLEDFDESPLPPHSPNSSGKRVTIQEE--- Candida_dubliniensis_CD36_cadu_61510 ---------------------------------------------------------------------------------------MSNQENLHPYLKRPSIKRPLNLLVRLSANFSEIRLPYLDDVSLPKSPLEKDKTIHQCEPVDIKSDYDIEGCTVGRNSFSYELEEIDATSSYYDYDDDDDMKSNNISISQTTLAMSTSTTTATLTEMGNSSTIKNFKPK--------------------------------------EYYYEADAGDGTHAIDQYVTGFRLGLTLFSCIISLFLVVLDQTIVTTIISDVGNKFK------SFDK--IGWLTSGYLLPMACLSLLNSKIAII-FGRKNCLLMGILIFEIGSLIAALSK-----NMSMLIGARVIQGLGGGTIQSMISIILTESVPIS--KRSLSYALLGITYS-CS--FLGPIIGAAILT--H--L---NWRW-CF---YINLPIGGTAFIVLLIGF-------NPP-----------K--------------------------------------------------------------------------------------VTGNI--------KD--------KL-----------KKI----DYMGIFLLTTGLVLILLGLSFGGS------KEF----KWNS------GYIIQNFIVGGFS-I-MAFLI--WT-F-------------------K-----YSP-N----------P-MILSIFI-KKFTILCACISAFTNFAVF-IALITYLATYFQVVFNKSAFKSSIAILPMIVSVVI-ASMLNGPFIR-R---------TRNV-KIPMIISGIF-APVGATLL-----LML----------------------------DK--D------ANN--SKQIGCQIVIGVSIGLQFQ-PSLLSAQLELP-KDVEG---SLIMITVFMSFLKSLGGTLGVIIAQLV-Y--NNSV-SVNFKNLLND---------LDTTS----IQYKTISRFNANEIVATPD------LLW--SAIPDSNIRGLVLDKVIVHALKNVYYVSIGLGVVCAIA--SLWTTN---K---KV-----PKD-----------------------------------------------EDVRK---------------------------------------------------------------------------------------------- Candida_albicans_SC5314_caal_a_19.3444 ----------------------------------------------------------------------------------------------------------------MTVQDNLHPYLKKPSIKRPLDLLVRLSANFSEIRLPYLDDVSLPPRSPLER------------SIHHELEEDKKSTYDIEGQTIGRNSFSYELENVDATSSYYAGDDADIHGADVVDYDLEDDNVSISQTTLAMSTSEMGGPSTIKNLKEKEYYYEADAGDGTHATEQYVTGFRLVLTLFSCIVSLFLVVLDQTIVTTIISDVGNNFK------AFDK--IGWLTSGYLLPMACLSLLNSKIAVA-FGRKNCLLVGILIFEIGSLVAALAK-----NMPMLIGARVIQGLGGGTIQSMISIILTESVPIS--KRSLSYALLGITYS-CS--FLGPIVGAAILT--H--L---NWRW-CF---YINLPIGGAAFIILLMGF-------NPP-----------K--------------------------------------------------------------------------------------VKGNI--------KD--------RL-----------KKI----DYMGTFLLTTGLVLILLALSFGG-------EEF----NWKS------GYIIQNFIVGGFS-I-IAFLV--WT-F-------------------K-----YAP-N----------P-MILSIFI-KNFTILCACISAFANFAVF-IALITYLATYFQVVFNKSAFKSSIAILPMIVSVVV-ASMLNGPFIR-R---------TSNV-KIPMVISGIC-APVGAAFL-----LML----------------------------DK--D------ANN--SKQIGCQIVIGVSIGLQFQ-ASLLSAQLEVP-KDVEG---SLIMITVFMSFLKSLGGTLGVVIAQLV-Y--NNSV-VVNFKKLLNN---------LDTTS----IQYKTISRFNASEIVASPE------LLW--SAIPDSNIRGLVLDKVIVHALKNVYYVSIGLGVVCAIA--SLWTTN---K---KV-----PKD-----------------------------------------------EEVRKSK-------------------------------------------------------------------------------------------- 'Candida albicans WO-1 caal b 05224' ----------------------------------------------------------------------------------------------------------------MTVQDNLHPYLKKPSIKRPLDLLVRLSANFSEIRLPYLDDVSLPPRSPLER------------SIHHELEEDKKSTYDIEGQTIGRNSFSYELENVDATSSYYAGDDADIHGADVVDYDLEDDNVSILKTTLAMSTSEMGGPSTIKNLKEKEYYYEADAGDGTHATEQYVTGFRLVLTLFSCIVSLFLVVLDQTIVTTIISDVGNNFK------AFDK--IGWLTSGYLLPMACLSLLNSKIAVA-FGRKNCLLVGILIFEIGSLVAALAK-----NMPMLIGARVIQGLGGGTIQSMISIILTESVPIS--KRSLSYALLGITYS-CS--FLGPIVGAAILT--H--L---NWRW-CF---YINLPIGGAAFIILLMGF-------NPP-----------K--------------------------------------------------------------------------------------VKGNI--------KD--------RL-----------KKI----DYMGTFLLTTGLVLILLALSFGG-------EEF----NWKS------GYIIQNFIVGGFS-I-IAFLV--WT-F-------------------K-----YAP-N----------P-MILSIFI-KNFTILCACISAFANFAVF-IALITYLATYFQVVFNKSAFKSSIAILPMIVSVVV-ASMLNGPFIR-R---------TSNV-KIPMVISGIC-APVGAAFL-----LML----------------------------DK--D------ANN--SKQIGCQIVIGVSIGLQFQ-ASLLSAQLEVP-KDVEG---SLIMITVFMSFLKSLGGTLGVVIAQLV-Y--NNSV-VVNFKKLLNN---------LDTTS----IQYKTISRFNASEIVASPE------LLW--SAIPDSNIRGLVLDKVIVHALKNVYYVSIGLGVVCAIA--SLWTTN---K---KV-----PKD-----------------------------------------------EDVRKSK-------------------------------------------------------------------------------------------- Saccharomyces_kluyveri_CBS3082_sakl0c05588g ---------------------------------------------------------------------------------------------------------------MLFFFLLSPPLQLVLTRRAPRAPFPTDILNKQKLWSNAYSQYACLVQTSVPQLQLPSAPIFQLTYQNSHLFYMAPTQMNNGDKDAESHCTTLE-----------------------------------------------------------TYPEAVQTPPGISRSLHTMAGIKLYTTIGSLTLVLFLAALDVLIISASIEVIAEQFK------DYSK--SGWIVSGYSLTEALLTLLWGRFATI-IGFKSSLLVSILIFEAGSLISAISN-----SMNMLIGGRVVAGIGGSGIQSLCFVIASTLTPDR--SRVIIISVLSCSYAVAA--VVGPFLGGALTT--H--V---TWRW-CF---YINLPIGGLAFVVLAMVY-------NPS----------GR-----------------------------KSIKDVFSVTKANYRRGMGRLLTARF-------------------------------YSKIP--------NW--------LV-----------FQI----DFVGFVLCTAGFTLLLLGLTFGG-------SMY----AWSS------GTIIVSLVVGVLL-I-TASLV--YD-FALFPRFKQVRK--------D-----ASC-M----------P-LLPWRVV-SRPGIFTSNTAVFLGCIAY-SAQIVYAVQFFQLVRGASAWTASIHLLSLDVSDII-TVVVGGVVNR-T---------TGHV-KPILVTGVVA-GVVGAGLL-----TLL----------------------------NN--E------SGS--SRHIGLLILPGVASGATLQ-SSLLSCQLQIP-KNSATFTPDFVSATTVHTFFVSLGMSFGSVLATTV-F--GASLRSRIASSGLDS------------------MSTKSVDELVTY-RTQNFD-----------------GVKSKLGYI-FSDSIRNVFWMALGFCGLAFVF--GIFTSS---K---KV-----NLE-----------------------------------------------DSVHRSKEGEEGDASIRKAETNHQYIV------------------------------------------------------------------------ Candida_parapsilosis_CDC_317_capa_02690 -------------------------------------------------------------------------------------------------------------------MIKALPPYSIIYNVEDISPSLKDTRHNSKNDILTMDLVAQAKVETFEDSKKVAKIRSGDEDEVDVSSRSSDNKVSSK-----------------------------------------------------------------------TTTKSIGIRRIEILQKQYQDPF-FVWFFFCIFLVAFGYRLDAMVRGKLQYYATSSYN------KHSL--FAAVTVMQSVISAAAQPCYARLSDR-FGRLELCILAIVFYSMGTVIQSQAY-----DINRFAGGSVIYEIGNTGFSIMLQVILADFSNLN--WRLLCVFIPAMPLIIIT-WVGGDVVDSVVEH--Y------SWNW-GIGMWAFIFPLSAVPLLGCLIHM-------QIK----------AR-------------------------------------KTPEWQEMTKEINSQRKHSKKSLAY------------------------WKTLV--------TE--------LF-----------WDL----DVVGLLHVILILGLILVPFTLAGG------VTF----KWAR------ASTIVPLVIGVVL-I-PVFVM--WE-A-------------------K-----FAR-S----------P-LMPLPLM-KDRGVWSALLIAIFLNWIW-YMPNDFMYTVLIVGLNASVKAATRITSLYSFVGTI-VGPLLGLVVV-R---------VRRL-KIFIIFGCIC-WAVSLGIL----FHFR----------------------------GA--NDGIESEKYL--DGVIGGLCFMGFGGGFLNPFSIQVSITTVTN-HE------YMSVILSLFYACYFIGSSIGASISGAI-W--TNKM-YDVILDKMQS------------------QGVPNAVQLAKLAYEAPFD------FIV--TNTWGSPARIAVATA-YAHVQRYLCITGLVLCFPLIIV--SFVLRD---H---RL-----DSV--------------------------------QSLDMDHDQEQGVVKDGKVVVNNYDDDIILDRLKSFSTSVRSRWGH-------------------------------------------------------------------- Eremothecium_gossypii_ATCC10895_ergo0g10076g -----------------------------------------------------------------------------------------------------------MGKRRKGLKTKQRDRLREFAKRKERQRALAGQNQAGVGQDAQPARRQHRPRAGEQSGLLEASRGTLVSDPSSGLSGLVASELEVQRQQEVCAAVTAESMATSGSGSSYGSTQKPT-----------------------------------------EVYLTATAVEAAKEDAGGLGATRRRVVMASMCLGVFLAALDGTIVTTLLDHIASEFN------ELPR--ISWIATAYLLSSATFQPLYGKLSDI-FGRRPLLVFSNLVFCLGALICGMSK-----NLWVLVLGRFVAGIGGGGLTSMCSITTTDIVPLR--SRALYQGICNVFFGLGT--ACGGLVGGLFADR-A--V---GWRM-AF---LVQVPLTLLSTTAIQLFL-------TLP-------------------------------------------------KPVDAHKGAGQRSIP----------------------------------WTTKL-------------------------------RMV----DWTGTVTLVVFLFCFTLVCSLYG-------EDL--------------PHLYLIFVVILLS-G-SYFIY--HE-L-------------------Y-----VAT-D----------P-ILPIRFL-ENRSVLAASLSNWFCMMGM-MTTGFYIPVYYASVLNMGPTDIGKRIVPSFFSTAF-GSLGAGYYMK-R---------TGKY-YWFLLAFCLV-GVLGQVQI-----SYV----------------------------TP--S------IST--WRQYCLYMIPGFGSAVLLT-VTLLALIVAVP-QR------HQAATTSISYAFRSTGSTLGVSIGGAI-F--RNGL-SNQ----LYS-----KLMPLQSPE----HPASELLRIIEK-AAHSTE------WVH---KEAPEFARHILIDC-YHYAGRYTFHFCLACMVLATVA--CCFIVE---Y---KL-----HAG-----------------------------------------------NTAPRPQRERTLNLSTLFVPKDYILIINVFTYSLYAPHF------------------------------------------------------------ Zygosaccharomyces_rouxii_CBS_732_zyro0g07414g -------------------------------------------------------------------------------------------------------------MENRSNSKISEPRFERQEVHVTDKEYNDVPPEFENVKYGQNAHQEVMPVDSDGE------------KQKLRPSLNMHGLPDKL-----------------------------------------------------------------------HVSKWLVIRQSELLAAEYDWWPFRILLLFCAFICGYGYGLDSNIRFIYTSYVTNSFS------EHSL--LSTVNVINAVISAASQIVYARLADV-FGRLTLFITAVVFYSMGTVIQSQSY-----NIETYAAGSIFYNLGYVGVVLVLLLILSDFSSLK--WRLFYQFAPTWPFIINT-WISGNITSRANPQ--E------NWSW-DIGMWAFIFPLSCVPLICCMLHM-------WWK----------AR-------------------------------------RTEEWKILNEEKTYFKTHG------------------------------LVSFI--------KE--------LF-----------WKL----DTIGTFIMTVSLGCILVPLTLAGG------TSS----KWDD------SQIIGPLVLGVVL-L-PMLIV--YE-L-------------------K-----WAR-E----------P-ILPWKLI-KDRAVWASMSISFLYDFIF-YMAYDYLYTVMIVAVDESVKSATRISSLSAFVSTV-FSPFFALYIT-R---------VTRL-KPYIIAGCGL-WMVAMGLL----YHFR----------------------------GG--K------SSH--SGIIGGLCVWGVGTTMFTY-PVNVSVQSATS-HE------NMATVTSLNYTLYRIGSAVGIAVSGCI-W--TQNL-YHEIFKRVKD------------------------AKIASYAYEQPYN------FIA--EYTWGTPIRQQVVEA-YMHVQKLETLVGLVFCAPLLLF--SLCLRD---P---ELTDEIAHNDLGEGEYIARDKDYIFDWIEDKCRKFVPGLHPKGRHPSFASQEAQEETRSIEEGQVPDDSSDVVMESGESNFKKLQGEFHSRRVSSHEQNI-------------------------------------------------------- 'Lodderomyces elongisporus NRRL YB-4239 loel 03789' --------------------------------------------------------------------------------------------------------------------------MATNNTQVNINERAVQNRSSQDDFGRQDLQNGSIAPGTATC------------NGNQDMDLNHSDANDSQNNYTSRTRNNSAQTSSTISPSSRRASDQEFNESPNQHPDETSHHE--------------------------KYYEADAGDGTKAHEQYLHGLP-LFLTLISCIISLFIVALDQTIVSTILTTVGDQFN------SFEK--VGWLTSGFMLPMACLVPSYGKISIA-FGRKVTLIVGIIIFEIGSLISALSN-----SMSLLIGGRVIQGIGGGAVQSMVMVILTESVPIS--RRSLAFACVAVVWSTSS--VLGPIIGGALEK--V------SWRW-CF---YINLPIGGFSLIVLMLGF-------HPP-----------R--------------------------------------------------------------------------------------AQGNI--------RE--------KL-----------KKI----DYIGTFLVTSGIVLVLLAMTFGG-------VDF----AWNS------AAIICLFVIGGVL-C-ILFLV--WN-F-------------------G-----FSS-N----------P-IIMKEFV-KSPAIMAAVISAMFNFAFF-IANLTYLAIYFQVIFDASSLQSGIDLLPLLITVTV-TSCCNSLFLN-V---------MKNV-KLTMILSGVL-SPIGTGLF-----LLL----------------------------GR--N------SSL--GLRIGIMIVSGISIGLQFQ-SSLLSAQLVAP-KDIPG---ALIMVTVFVNFMKSLASTISVTIAQLL-F--QTTG-ATY----IKD-----LQNTLSQDT----PGYEQFKQIPSETLISNPR------SVK----NLSSEIQDQVLDQ-FVKALKNVFYFGLALAVVCFFA--SFCTTN---K---KI-----PKN--------------------------------KDIKTKESGDEEDDKEEEEDKGEDKGNREGDGEGNVESKEMKKRVESNRSVDASASPSMSAESKSDVENSEEEVRMEKNKDSANA----------------------------- Saccharomyces_mikatae_IFO_1815_sami_a_c1083_3691 MGKKDRQRKKLREFAKLKNRQRNLKESVQNLKKEVQQKAVCSEHLDLVQLENDKSEEINDESEEINENVPLLSTHGGQKEEKVSKVPDVDIINTHPLHS-SKNDDSHQTEADCAERKAGNKTDHDYAKSLSQDEPGIKLPLQSSMTDFTDRSISPLQSITSNN------------TPMSEHELPASSTNSLERGDNMPIVQPSSQIPTGQILSMAASPPEVPGGRAQMDPYGYGSIS--------RTIEDV------------ESGANPTYVANSSSDELVHDLTRKRIFSSCMCTYLFFIAMDSSIILVIASKIASEFH------ELWR--LSLVISVYLLGNAIGQLMFLKLSLV-SGVKLLLCVAQFSFILGSYLSWSSI-----HFWTFILARSVTGFGSGSLIALKSTIMNRFSQKN--ENQYPLSTSMTVFSLGV--AVGPFLVSFFDS-----SHGSGWKN-AF---LIPVPFCLVNASIMLADI-------YSV----------KN-----------------------------------------TIHHEG---------------------------------------PTTTL--------QK--------RF-----------KKVLWSPDLYEILTLALFLLCFVQATSLDS-------TRL----EHST------MIQEIIFSVIIIC-G-VLFFV--IE-KS------------------D-----VRM-N----------S-VFSLSLQ-GDKHLIWTMMGIFFCFAAL-MCIIPFGTTYFMIVLNLDTLEIAERLLPFFFSIVV-GYFSVCYFWNSE---------RQNYLFKFVLSGVTL--LLYVALM------------------------------------GM--N------LSLSVWKQYTCLSLPLLGSSMILT-LLSTLYHEYHE-QR------KSPISGSIAYCYAAMGGTIGVSSAGYV-F--HKTL--------VRT-------------------------------MNEEVM-----------KFSKQGYLKKDLFKI-----IKHATQIQIG-------------------Y--------------------------------------------------------------------------------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_YJM789_sace_e_1018 -----------------------------------MGKKDRQRKKLREFAKLKNRQRNLRKSVQTLKNEVQREAKVPGTSNQIALGNDKIEEINENSPLLSAPNKKEEVSIPKAVDIGTIDAQPLHEGPKIDNSPQNEVNSIKGKPADKANEDDLKPPSQNET----CGNSALQSSITDFSDRSVSPLQSITSGNTPMSEHELPVSSSNSFERADDMPVVQADNQTSSSKSLHIVAPPPEVPVSGDEITSYGYGSIPQSIGDVENGLNPPYVENTSSDELVHDLTRRRIFSSCMCTYLFFIAMDSSIILVIASKIASEFH------ELWR--LSLVISAYLLSNAIGQLVFLKLSLI-SSVKLLLCIAQFSFILGGYLSWSSA-----HFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKN--DSRYSLSASMITFAMGV--VIGPFMVNLFDS-----SHGSGWRN-AF---LIPVPFCLVNASIMLADM-------YSV----------------------------------------------------KSTLHGG---------------------------------------PTPTL--------WK--------RF-----------KNTLLSPDLYEILTLTLFLLCFVQVTSLDL-------TGL----KNNT------MIQALLFSVIIVC-G-ILFFL--IE-TN------------------D-----TYM-N----------S-VISMSLQ-GDKRLIWTMIGISFCFAAL-MCIIPFGTTYFIIVLNLSTLQLAERLSPFFFSIVL-GYFSVSYFWKSK---------GQNFLLKFVLSGATL--LLYVALM------------------------------------GV--S------LNLPVWKQYICLSLPFLGSSMILT-LLSNLYHEYHE-QR------KSPISGSIVYCFGAVGGTVGISLGGYV-F--HKTL-IKI----MHE-----KVMPFSKQG----YLKKDLLKIIKH-ATESSD------WVH---ESAPKFVFQTLIEC-YLQACRNVFKLSTLFFTITVV---AIFIFN-------RI-------------------------------------------------------H-------------------------------------------------------------------------------------------------- Saccharomyces_kudriavzevii_IFO_1802_saku_c1927.9 -----------------------------------MGKKDRQRKKLREFAKLKNRQQKLQNSVQNLKNEVQREVGESENPNPIAIENDKSEENKENTPLLLTSSERREDDGSKPLDIDTFDTRPFQERSKSGNPVQAEGDDMEGKSEDKADQDHHKFLSQDES----GTKSPLQNSMIDFSDRSISPLQSITSDHTQMSERELPGSSTNSLEGNGDIHVAQSESERPTSKTLATATSAPAVPVSRAEISPYGYGSISQTIEDVEDETDPSYIASTSSDAFVHQETRRRIFSSCMCTYLFFIAMDSSILLVIVSKIASEFH------ELWR--LSLIVSVYLLSNAIGQLLFLKLSII-SSVKLLLCMAQFSFILGSYLSWSSS-----HFWTFIFARFVAGFGSGSLIALKSTIMNRFSQKN--ESRYSLSASVIIFSLGV--AIGPFVVGLFDS-----SHGSGWKN-AF---LIPVPFCLVNASIMLADI-------YSV----------KD-----------------------------------------NLHHEG---------------------------------------STFTL--------WK--------RV-----------KKILLSPDLYEILTLTLFLLCFVQVTTLDL-------TEL----EHRT------MIQWVLFSVILIC-G-VLFWL--IE-A-------------------N-----DTYMN----------S-VISMSLQ-GDKRLIWTVTGISFCFSAL-MCIIPFGTTYFTIVLNLNTLQIAERLLPFFFSIVI-GYFSVCYFWKSK---------KQNYLLKFVLSGVTL--ILYITLM------------------------------------GV--G------LSLPVWKQYVCLSLPFLGSSMLLT-LLSSLYHEYHE-QR------KSLNSGSIVYCFGAIGGTIGISLGGYV-F--HKTL-TKS----LHE-----EVMKFSKQG----YLKKDLLKIIKH-ATESSD------WVH---ESAPKFIFKTLIEC-YLQACRNVFKLSAVFFTIMVIS--MFFFNKIN----------------------------------------------------------------------------------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_S288C_sace0d07920g -----------------------------------MGKKDRQRKKLREFAKLKNRQRNLRKSVQTLKNEVQREAKVPRTSNQIALGNDKIEEINENSPLLSAPSKQEEVSIPKAVDIDTIDAQPLHEGPKIDDSPQDEVNSIKGKPADKANEDDLKPPSQHEA----CGNSALQSSITDFSDRSVSPLQSITSCNTPMSEHELPVSSSNSFERADDMPVVQADNQTSSSKSLHIVAPSPEVPVSGDEITSYGYGSIPQSIGDVENGLNPPYVENTSSDELVHDLTRRRIFSSCMCTYLFFIAMDSSIILVIASKIASEFH------ELWR--LSLVISAYLLSNAIGQLVFLKLSLI-SSVKLLLCIAQFSFILGGYLSWSSA-----HFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKN--DSRYSLSASMITFAMGV--VIGPFMMNLFDS-----SHGSGWRN-AF---LIPVPFCLVNASIMLADM-------YSV----------------------------------------------------KSTLYGR---------------------------------------PTPTL--------WK--------RF-----------KNTLLSPDLYEILTLTLFLLCFVQVTSLDL-------TGL----KNNT------MIQALLFSVIIVC-G-ILFFL--IE-TS------------------D-----TYM-N----------S-VISMSLQ-GDKRLIWTMIGISFCFAAL-MCIIPFGTTYFIIVLNLSTLQLAERLSPFFFSIVL-GYFSVSYFWKSK---------GQNFLLKFVLSGATL--LLYVALM------------------------------------GV--S------LNLPVWKQYICLSLPFLGSSMILT-LLSNLYHEYHE-QR------KSPISGSIVYCFGAVGGTVGISLGGYV-F--HKTL-IKL----MHE-----KVMPFSKQG----YLKKDLLKIIKH-ATESSD------WVH---ESAPKFVFQTLIEC-YLQACRNVFKLSTLFFTITVV---AIFIFN-------RI-------------------------------------------------------HCRSQNCLSLS---------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_EC1118_sace_b_1d0_3730g -----------------------------------MGKKDRQRKKLREFAKLKNRQRNLRKSVQTLKNEVQREAKVPRTSNQIALGNDKIEEINENSPLLSAPSKQEEVSIPKAVDIDTIDAQPLHEGPKIDDSPQDEVNSIKGKPADKANEDDLKPASQHEA----CGNSALQSSITDFSDRSVSPLQSITSCNTPMSEHELPVSSSNSFERADDMPVVQADNQTSSSKSLHIVAPSPEVPVSGDEITSYGYGSIPQSIGDVENGLNPPYVENTSSDELVHDLTRRRIFSSCMCTYLFFIAMDSSIILVIASKIASEFH------ELWR--LSLVISAYLLSNAIGQLVFLKLSLI-SSVKLLLCIAQFSFILGGYLSWSSA-----HFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKN--DSRYSLSASMITFAMGV--VIGPFMMNLFDS-----SHGSGWRN-AF---LIPVPFCLVNASIMLADM-------YSV----------KS------------------------------------------TLYGR---------------------------------------PTPTL--------WK--------RF-----------KNTLLSPDLYEILTLTLFLLCFVQVTSLDL-------TGL----KNNT------MIQALLFSVIIVC-G-ILFFL--IE-TS------------------D-----TYM-N----------S-VISMSLQ-GDKRLIWTMIGISFCFAAL-MCIIPFGTTYFIIVLNLSTLQLAERLSPFFFSIVL-GYFSVSYFWKSK---------GQNFLLKFVLSGATL--LLYVALM------------------------------------GV--S------LNLPVWKQYICLSLPFLGSSMILT-LLSNLYHEYHE-QR------KSPISGSIVYCFGAVGGTVGISLGGYV-F--HKTL-IKL----MHE-----KVMPFSKQG----YLKKDLLKIIKH-ATESSD------WVH---ESAPKFVFQTLIEC-YLQACRNVFKLSTLFFTITVV---AIFIFN-------RI-------------------------------------------------------HCRSQNCLSLS---------------------------------------------------------------------------------------- Saccharomyces_cerevisiae_JAY291_sace_c_00011 -----------------------------------MGKKDRQRKKLREFAKLKNRQRNLRKSVQTLKNEVQREAKVPRTSNQIALGNDKIEEINENSPLLSAPSKQEEVSIPKAVDIDTIDAQPLHEGPKIDDSPQDEVNSIKGKPADKANEDDLKPPSQHEA----CGNSALQSSITDFSDRSVSPLQSITSCNTPMSEHELPVSSSNSFERADDMPVVQADNQTSSSKSLHIVAPSPEVPVSGDEITSYGYGSIPQSIGDVENGLNPPYVENTSSDELVHDLTRRRIFSSCMCTYLFFIAMDSSIILVIASKIASEFH------ELWR--LSLVISAYLLSNAIGQLVFLKLSLI-SSVKLLLCIAQFSFILGGYLSWSSA-----HFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKN--DSRYSLSASMITFAMGV--VIGPFMMNLFDS-----SHGSGWRN-AF---LIPVPFCLVNASIMLADM-------YSV----------KS------------------------------------------TLYGR---------------------------------------PTPTL--------WK--------RF-----------KNTLLSPDLYEILTLTLFLLCFVQVTSLDL-------TGL----KNNT------MIQALLFSVIIVC-G-ILFFL--IE-TS------------------D-----TYM-N----------S-VISMSLQ-GDKRLIWTMIGISFCFAAL-MCIIPFGTTYFIIVLNLSTLQLAERLSPFFFSIVL-GYFSVSYFWKSK---------GQNFLLKFVLSGATL--LLYVALM------------------------------------GV--S------LNLPVWKQYICLSLPFLGSSMILT-LLSNLYHEYHE-QR------KSPISGSIVYCFGAVGGTVGISLGGYV-F--HKTL-IKL----MHE-----KVMPFSKQG----YLKKDLLKIIKH-ATESSD------WVH---ESAPKFVFQTLIEC-YLQACRNVFKLSTLFFTITVV---AIFIFN-------RI-------------------------------------------------------HCRSQNCLSLS---------------------------------------------------------------------------------------- 'Saccharomyces cerevisiae RM11-1A sace d 00400' -----------------------------------MGKKDRQRKKLREFAKLKNRQRNLRKSVQTLKNEVQREAKVPRTSNQIALGNDKIEEINENSPLLSAPSKQEEVSIPKAVDIDTIDAQPLHEGPKIDDSPQDEVNSIKGKPADKANEDDLKPPSQHEA----CGNSALQSSITDFSDRSVSPLQSITSCNTPMSEHELPVSSSNSFERADDMPVVQADNQTSSSKSLHIVAPSPEVPVSGDEITSYGYGSIPQSIGDVENGLNPPYVENTSSDELVHDLTRRRIFSSCMCTYLFFIAMDSSIILVIASKIASEFH------ELWR--LSLVITAYLLSNAIGQLVFLKLSLI-SSVKLLLCIAQFSFILGGYLSWSSA-----HFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKN--DGRYSLSASMITFAMGV--VIGPFMMNLFDS-----SHGSGWRN-AF---LIPVPFCLVNASIMLADM-------YSV----------------------------------------------------KSTLYGR---------------------------------------PTPTL--------WK--------RF-----------KNTLLSPDLYEILTLTLFLLCFVQVTSLDL-------TGL----KNNT------MIQALLFSVIIVC-G-ILFFL--IE-TS------------------D-----TYM-N----------S-VISMSLQ-GDKRLIWTMIGISFCFAAL-MCIIPFGTTYFIIVLNLSTLQLAERLSPFFFSIVL-GYFSVSYFWKSK---------GQNFLLKFVLSGATL--LLYVALM------------------------------------GV--S------LNLPVWKQYICLSLPFLGSSMILT-LLSNLYHEYHE-QR------KSPISGSIVYCFGAVGGTVGISLGGYV-F--HKTL-IKL----MHE-----KVMPFSKQG----YLKKDLLKIIKH-ATESSD------WVH---ESAPKFVFQTLIEC-YLQACRNVFKLSTLFFTITVV---AIFIFN-------RI-------------------------------------------------------HCRSQNCLSLS---------------------------------------------------------------------------------------- 'Candida tropicalis MYA-3404 catr 02833' -------------------------------------------------------------MSNPYDEPQKPSSVPPELEKPPVPPSMDKPKPRHPYLRKPSIKRPLDYLVRLSANLSDIKLPYLDDTISSNHPSFHEKPRSVTDESRFDNNSSHYPDDDDENDEIFDDDAATAGKLSSTLDRKNEDQLSYYENDEQREIGENESISASTLAMSTHEMGTSSSHQNLKKKK--------------------------------QYYYEADAGDGTHSTDQYVTGFRLVLTLFSCIVSLFLVVLDQTIVTTIISDVGNSFN------AFDK--IGWLTSGYLLPMACLSLLNSKIAVA-FGRKNCLLAGIVIFQIGSLVSALAK-----NMPTLIGGRVIQGIGGGTIQSIISIILTESVPIS--KRSLSYALLGITYS-CS--FLGPIVGAAILT--N--L---SWRW-CF---WINLPIGGAAFGILLLGF-------NPP-----------K--------------------------------------------------------------------------------------VKGNF--------KE--------RL-----------KKI----DYMGTFLLTTGLVLILLALSFGG-------VEF----AWKS------GYIIQNFLVGGFS-I-IAFII--WT-F-------------------K-----YSP-N----------P-MILPIFI-KKFTILCACISSFTNFAVF-IALITYLATYYQVIFNKSAFKSSIAILPMIVSVVV-ASMLNGPFLR-R---------TRNV-KASMMLSGIL-APVGSALL-----LLL----------------------------NR--N------SSI--HAQIGLPIPVGVSIGLQFQ-ASLLSSQLEVP-KDIEG---SLIMITVFLSFLKSLGGTLSVSFAQLV-Y--NTSV-KLKFESFVNN---------LDHTS----IQYKTLSVFQADEIVSTPD------VLW--NDIPDANIRNLVLDRVIMFALKNVFYMALGFAFICTIA--SLWTTN---K---KV-----PKDKDVAHNEEEKGAELTRNGSVLKRTSSIISRYSATTIMSNSTMHGSMSYLDARSHSPTNTEIISKYATPNASESKITKPTTAPTVHQNISMPQYTKTNKSPQLPPKDKFTTYTQVKPKPTFKSNNTTNSPRYNAAFVSPIAKKKRNK ; END; BEGIN TREES; Title 'Additional_file_3_phylogenetic_tree'; LINK Taxa = Taxa; TRANSLATE 1 Pichia_stipitis_CBS_6054_pist_igi19985888, 2 Saccharomyces_cerevisiae_S288C_sace0c00132g, 3 Saccharomyces_cerevisiae_YJM789_sace_e_3474, 4 Pichia_stipitis_CBS_6054_pist_igi19987745, 5 Pichia_stipitis_CBS_6054_pist_igi20837975, 6 Saccharomyces_cerevisiae_S288C_sace0b09020g, 7 Saccharomyces_cerevisiae_EC1118_sace_b_1b15_4786g, 8 Saccharomyces_cerevisiae_JAY291_sace_c_01581, 9 'Saccharomyces cerevisiae RM11-1A sace d 02679', 10 'Saccharomyces paradoxus NRRL Y-17217 sapa c84 2183', 11 Candida_lusitaniae_ATCC_42720_calu_03396, 12 Pichia_stipitis_CBS_6054_pist_igi20835632, 13 'Candida tropicalis MYA-3404 catr 02586', 14 Pichia_stipitis_CBS_6054_pist_igi19138887, 15 Kluyveromyces_lactis_CLIB210_klla0b00352g, 16 'Saccharomyces bayanus 623-6C saba a 556.17', 17 Candida_albicans_SC5314_caal_a_19.304, 18 'Candida albicans WO-1 caal b 02627', 19 Candida_dubliniensis_CD36_cadu_83050, 20 Debaryomyces_hansenii_CBS767_deha2d11572g, 21 'Kluyveromyces waltii NCYC2644 klwa 034-snap.4', 22 Candida_guilliermondii_ATCC_6260_cagu_00085, 23 Candida_guilliermondii_ATCC_6260_cagu_05158, 24 Kluyveromyces_thermotolerans_CBS6340_klth0c10560g, 25 'Kluyveromyces waltii NCYC2644 klwa 042-snap.2', 26 'Kluyveromyces waltii NCYC2644 klwa 116-snap.16', 27 'Saccharomyces bayanus 623-6C saba a 673.19', 28 Saccharomyces_bayanus_MCYC_623_saba_b_c773_24081, 29 Saccharomyces_cerevisiae_S288C_sace0o12012g, 30 Saccharomyces_cerevisiae_JAY291_sace_c_04464, 31 'Saccharomyces cerevisiae RM11-1A sace d 01751', 32 Saccharomyces_cerevisiae_YJM789_sace_e_5421, 33 'Saccharomyces paradoxus NRRL Y-17217 sapa c93 21663', 34 Saccharomyces_kudriavzevii_IFO_1802_saku_c2036.7, 35 Saccharomyces_mikatae_IFO_1815_sami_a_c511_20564, 36 Saccharomyces_mikatae_IFO_1815_sami_b_c1722.1, 37 'Saccharomyces castelli NRRL Y-12630 saca 696.43', 38 Candida_dubliniensis_CD36_cadu_10040, 39 Candida_guilliermondii_ATCC_6260_cagu_02196, 40 'Kluyveromyces waltii NCYC2644 klwa 333-snap.4', 41 Candida_albicans_SC5314_caal_a_19.2350, 42 Candida_guilliermondii_ATCC_6260_cagu_05806, 43 Pichia_pastoris_GS115_pipa_3g00675, 44 Saccharomyces_kluyveri_CBS3082_sakl0d01386g, 45 Candida_guilliermondii_ATCC_6260_cagu_05180, 46 Kluyveromyces_thermotolerans_CBS6340_klth0c03806g, 47 Pichia_stipitis_CBS_6054_pist_igi16597754, 48 Kluyveromyces_polysporus_DSM_70294_klpo_541.16, 49 Candida_glabrata_CBS138_cagl0l02519g, 50 'Lodderomyces elongisporus NRRL YB-4239 loel 03562', 51 Candida_parapsilosis_CDC_317_capa_03043, 52 Debaryomyces_hansenii_CBS767_deha2c03718g, 53 Candida_glabrata_CBS138_cagl0b02343g, 54 'Candida tropicalis MYA-3404 catr 05874', 55 Saccharomyces_kluyveri_CBS3082_sakl0f00198g, 56 'Saccharomyces castelli NRRL Y-12630 saca 551.4', 57 Saccharomyces_kudriavzevii_IFO_1802_saku_c2070.4, 58 'Saccharomyces bayanus 623-6C saba a 601.4', 59 Saccharomyces_bayanus_MCYC_623_saba_b_c68_15452, 60 Saccharomyces_cerevisiae_S288C_sace0m09768g, 61 Saccharomyces_cerevisiae_EC1118_sace_b_1m3_4896g, 62 Saccharomyces_cerevisiae_JAY291_sace_c_03767, 63 'Saccharomyces cerevisiae RM11-1A sace d 02175', 64 Saccharomyces_cerevisiae_YJM789_sace_e_4461, 65 'Saccharomyces paradoxus NRRL Y-17217 sapa c419 17887', 66 Candida_guilliermondii_ATCC_6260_cagu_04492, 67 'Saccharomyces castelli NRRL Y-12630 saca 692.14', 68 Saccharomyces_cerevisiae_S288C_sace0m00462g, 69 Saccharomyces_cerevisiae_EC1118_sace_b_1m3_0188g, 70 Saccharomyces_cerevisiae_JAY291_sace_c_04366, 71 'Saccharomyces cerevisiae RM11-1A sace d 01783', 72 Saccharomyces_cerevisiae_YJM789_sace_e_4060, 73 'Candida tropicalis MYA-3404 catr 03278', 74 'Saccharomyces bayanus 623-6C saba a 671.27', 75 Saccharomyces_bayanus_MCYC_623_saba_b_c753_19471, 76 Saccharomyces_cerevisiae_S288C_sace0p10472g, 77 Saccharomyces_cerevisiae_EC1118_sace_b_1p2_5457g, 78 Saccharomyces_cerevisiae_JAY291_sace_c_02068, 79 'Saccharomyces cerevisiae RM11-1A sace d 04120', 80 Saccharomyces_cerevisiae_YJM789_sace_e_5897, 81 Saccharomyces_kudriavzevii_IFO_1802_saku_c1565.3, 82 Saccharomyces_mikatae_IFO_1815_sami_a_c468_17485, 83 'Saccharomyces paradoxus NRRL Y-17217 sapa c565 22682', 84 Saccharomyces_cerevisiae_JAY291_sace_c_05667, 85 Saccharomyces_kluyveri_CBS3082_sakl0f00440g, 86 Saccharomyces_mikatae_IFO_1815_sami_a_c1152_6745, 87 Saccharomyces_mikatae_IFO_1815_sami_a_c208_6715, 88 Saccharomyces_mikatae_IFO_1815_sami_b_c2021.3, 89 'Saccharomyces paradoxus NRRL Y-17217 sapa c345 7127', 90 Saccharomyces_mikatae_IFO_1815_sami_a_c551_15970, 91 'Saccharomyces paradoxus NRRL Y-17217 sapa c443 17778', 92 Pichia_stipitis_CBS_6054_pist_igi16258608, 93 Kluyveromyces_thermotolerans_CBS6340_klth0h16214g, 94 Pichia_stipitis_CBS_6054_pist_igi18293386, 95 Yarrowia_lipolytica_CLIB122_yali0f06908g, 96 Pichia_pastoris_GS115_pipa_3g03370, 97 Kluyveromyces_lactis_CLIB210_klla0c18931g, 98 Kluyveromyces_lactis_CLIB210_klla0f17776g, 99 'Kluyveromyces waltii NCYC2644 klwa 298-snap.4', 100 Pichia_pastoris_GS115_pipa_3g02865, 101 'Saccharomyces bayanus 623-6C saba a 604.18', 102 Saccharomyces_bayanus_MCYC_623_saba_b_c553_18284, 103 Debaryomyces_hansenii_CBS767_deha2f27082g, 104 Candida_glabrata_CBS138_cagl0m03003g, 105 'Kluyveromyces waltii NCYC2644 klwa 093-snap.33', 106 Candida_albicans_SC5314_caal_a_19.7554, 107 'Candida albicans WO-1 caal b 02248', 108 Candida_dubliniensis_CD36_cadu_34960, 109 Saccharomyces_kudriavzevii_IFO_1802_saku_c1455.3, 110 Saccharomyces_mikatae_IFO_1815_sami_a_c1010_16957, 111 'Saccharomyces bayanus 623-6C saba a 622.18', 112 Saccharomyces_bayanus_MCYC_623_saba_b_c596_2320, 113 Saccharomyces_cerevisiae_S288C_sace0m05214g, 114 Saccharomyces_cerevisiae_EC1118_sace_b_1m3_2575g, 115 Saccharomyces_cerevisiae_JAY291_sace_c_00976, 116 'Saccharomyces cerevisiae RM11-1A sace d 01978', 117 Saccharomyces_cerevisiae_YJM789_sace_e_4257, 118 Saccharomyces_kudriavzevii_IFO_1802_saku_c1803.5, 119 'Saccharomyces paradoxus NRRL Y-17217 sapa c170 16969', 120 Zygosaccharomyces_rouxii_CBS_732_zyro0g03234g, 121 Candida_guilliermondii_ATCC_6260_cagu_00124, 122 'Saccharomyces castelli NRRL Y-12630 saca 616.4', 123 Candida_glabrata_CBS138_cagl0j01375g, 124 Candida_lusitaniae_ATCC_42720_calu_02219, 125 'Saccharomyces paradoxus NRRL Y-17217 sapa c214 2150', 126 Pichia_stipitis_CBS_6054_pist_igi19055263, 127 Saccharomyces_kluyveri_CBS3082_sakl0c02178g, 128 Saccharomyces_kluyveri_CBS3082_sakl0e04246g, 129 Yarrowia_lipolytica_CLIB122_yali0e18095g, 130 Pichia_stipitis_CBS_6054_pist_igi19986138, 131 Eremothecium_gossypii_ATCC10895_ergo0b04004g, 132 Debaryomyces_hansenii_CBS767_deha2e02794g, 133 Kluyveromyces_thermotolerans_CBS6340_klth0b00132g, 134 Kluyveromyces_thermotolerans_CBS6340_klth0b10142g, 135 Kluyveromyces_thermotolerans_CBS6340_klth0h05456g, 136 'Saccharomyces castelli NRRL Y-12630 saca 660.3', 137 Saccharomyces_mikatae_IFO_1815_sami_a_c699_5023, 138 Pichia_stipitis_CBS_6054_pist_igi16259683, 139 Saccharomyces_kluyveri_CBS3082_sakl0a08228g, 140 Yarrowia_lipolytica_CLIB122_yali0c22660g, 141 'Kluyveromyces waltii NCYC2644 klwa 305-snap.8', 142 Pichia_pastoris_GS115_pipa_1g01100, 143 Saccharomyces_kluyveri_CBS3082_sakl0e02992g, 144 Kluyveromyces_lactis_CLIB210_klla0f13684g, 145 Kluyveromyces_thermotolerans_CBS6340_klth0d16962g, 146 Saccharomyces_mikatae_IFO_1815_sami_a_c322_9452, 147 Candida_guilliermondii_ATCC_6260_cagu_01265, 148 Kluyveromyces_thermotolerans_CBS6340_klth0c10142g, 149 Saccharomyces_kluyveri_CBS3082_sakl0a07480g, 150 Kluyveromyces_thermotolerans_CBS6340_klth0e16720g, 151 Candida_guilliermondii_ATCC_6260_cagu_04556, 152 Candida_lusitaniae_ATCC_42720_calu_04865, 153 Kluyveromyces_thermotolerans_CBS6340_klth0d05434g, 154 Zygosaccharomyces_rouxii_CBS_732_zyro0a00330g, 155 Zygosaccharomyces_rouxii_CBS_732_zyro0g21890g, 156 'Kluyveromyces waltii NCYC2644 klwa 074-snap.3', 157 Kluyveromyces_lactis_CLIB210_klla0a04631g, 158 Candida_dubliniensis_CD36_cadu_43440, 159 Saccharomyces_mikatae_IFO_1815_sami_a_c124_14118, 160 Saccharomyces_mikatae_IFO_1815_sami_b_c2470.1, 161 Candida_albicans_SC5314_caal_a_19.1308, 162 'Candida albicans WO-1 caal b 03443', 163 Candida_lusitaniae_ATCC_42720_calu_02516, 164 Saccharomyces_cerevisiae_S288C_sace0k07392g, 165 'Saccharomyces cerevisiae RM11-1A sace d 05344', 166 Saccharomyces_cerevisiae_YJM789_sace_e_0518, 167 'Saccharomyces paradoxus NRRL Y-17217 sapa c403 13057', 168 'Saccharomyces paradoxus NRRL Y-17217 sapa c84 2187', 169 Saccharomyces_cerevisiae_EC1118_sace_b_1k5_3763g, 170 Candida_guilliermondii_ATCC_6260_cagu_00118, 171 Candida_parapsilosis_CDC_317_capa_01507, 172 Candida_guilliermondii_ATCC_6260_cagu_04884, 173 'Kluyveromyces waltii NCYC2644 klwa 281-snap.8', 174 Candida_lusitaniae_ATCC_42720_calu_04792, 175 'Kluyveromyces waltii NCYC2644 klwa 073-snap.6', 176 Zygosaccharomyces_rouxii_CBS_732_zyro0c01430g, 177 'Candida tropicalis MYA-3404 catr 05923', 178 'Kluyveromyces waltii NCYC2644 klwa 021-snap.20', 179 Candida_guilliermondii_ATCC_6260_cagu_05184, 180 Kluyveromyces_thermotolerans_CBS6340_klth0g13464g, 181 Debaryomyces_hansenii_CBS767_deha2e02948g, 182 Candida_lusitaniae_ATCC_42720_calu_00809, 183 Kluyveromyces_polysporus_DSM_70294_klpo_416.6, 184 Candida_parapsilosis_CDC_317_capa_02998, 185 Saccharomyces_kluyveri_CBS3082_sakl0a00726g, 186 'Candida tropicalis MYA-3404 catr 01806', 187 Pichia_stipitis_CBS_6054_pist_igi16601804, 188 Candida_dubliniensis_CD36_cadu_22250, 189 Candida_guilliermondii_ATCC_6260_cagu_00173, 190 Candida_lusitaniae_ATCC_42720_calu_04864, 191 'Kluyveromyces waltii NCYC2644 klwa 018-snap.54', 192 Candida_albicans_SC5314_caal_a_19.2179, 193 Candida_albicans_SC5314_caal_a_19.7336, 194 'Candida albicans WO-1 caal b 02209', 195 'Candida albicans WO-1 caal b 05897', 196 Candida_parapsilosis_CDC_317_capa_02455, 197 Saccharomyces_mikatae_IFO_1815_sami_a_c633_10615, 198 'Saccharomyces bayanus 623-6C saba a 479.6', 199 'Saccharomyces bayanus 623-6C saba a 673.6', 200 Saccharomyces_cerevisiae_S288C_sace0o00308g, 201 Saccharomyces_cerevisiae_EC1118_sace_b_1o4_0034g, 202 'Saccharomyces cerevisiae RM11-1A sace d 01250', 203 'Saccharomyces paradoxus NRRL Y-17217 sapa c416 24437', 204 Kluyveromyces_polysporus_DSM_70294_klpo_416.5, 205 Kluyveromyces_thermotolerans_CBS6340_klth0d18150g, 206 Pichia_stipitis_CBS_6054_pist_igi19986137, 207 Candida_parapsilosis_CDC_317_capa_02454, 208 'Candida tropicalis MYA-3404 catr 03960', 209 Yarrowia_lipolytica_CLIB122_yali0f28017g, 210 Pichia_stipitis_CBS_6054_pist_igi16603947, 211 'Kluyveromyces waltii NCYC2644 klwa 265-snap.3', 212 'Candida tropicalis MYA-3404 catr 04131', 213 Kluyveromyces_lactis_CLIB210_klla0d19941g, 214 'Kluyveromyces waltii NCYC2644 klwa 298-snap.3', 215 Saccharomyces_kluyveri_CBS3082_sakl0c12122g, 216 Yarrowia_lipolytica_CLIB122_yali0d15972g, 217 Yarrowia_lipolytica_CLIB122_yali0f20922g, 218 Saccharomyces_mikatae_IFO_1815_sami_b_c2470.2, 219 Saccharomyces_cerevisiae_S288C_sace0g11000g, 220 Saccharomyces_cerevisiae_EC1118_sace_b_1g1_5567g, 221 Saccharomyces_cerevisiae_JAY291_sace_c_01814, 222 'Saccharomyces cerevisiae RM11-1A sace d 00798', 223 Saccharomyces_cerevisiae_YJM789_sace_e_2117, 224 'Saccharomyces castelli NRRL Y-12630 saca 705.26', 225 Kluyveromyces_thermotolerans_CBS6340_klth0a01562g, 226 Pichia_stipitis_CBS_6054_pist_igi16606996, 227 Saccharomyces_cerevisiae_S288C_sace0c00110g, 228 Saccharomyces_cerevisiae_S288C_sace0k07414g, 229 Saccharomyces_cerevisiae_JAY291_sace_c_04015, 230 'Saccharomyces cerevisiae RM11-1A sace d 05343', 231 Saccharomyces_cerevisiae_YJM789_sace_e_0517, 232 'Saccharomyces paradoxus NRRL Y-17217 sapa c403 13053', 233 Kluyveromyces_thermotolerans_CBS6340_klth0d00506g, 234 Saccharomyces_kluyveri_CBS3082_sakl0g03300g, 235 Kluyveromyces_polysporus_DSM_70294_klpo_358.4, 236 'Lodderomyces elongisporus NRRL YB-4239 loel 00428', 237 'Lodderomyces elongisporus NRRL YB-4239 loel 02353', 238 Saccharomyces_kluyveri_CBS3082_sakl0f00792g, 239 Kluyveromyces_thermotolerans_CBS6340_klth0b00594g, 240 'Kluyveromyces waltii NCYC2644 klwa 331-snap.3', 241 Pichia_pastoris_GS115_pipa_4g02960, 242 Yarrowia_lipolytica_CLIB122_yali0c16225g, 243 Candida_guilliermondii_ATCC_6260_cagu_04513, 244 Kluyveromyces_thermotolerans_CBS6340_klth0a07964g, 245 'Kluyveromyces waltii NCYC2644 klwa 001-snap.4', 246 Candida_albicans_SC5314_caal_a_19.4779, 247 'Candida albicans WO-1 caal b 00508', 248 Candida_dubliniensis_CD36_cadu_08690, 249 Kluyveromyces_thermotolerans_CBS6340_klth0b10450g, 250 Kluyveromyces_thermotolerans_CBS6340_klth0d00110g, 251 'Saccharomyces castelli NRRL Y-12630 saca 663.28', 252 Saccharomyces_cerevisiae_EC1118_sace_b_1h21_0023g, 253 Saccharomyces_kluyveri_CBS3082_sakl0e00132g, 254 Saccharomyces_kluyveri_CBS3082_sakl0f00110g, 255 Zygosaccharomyces_rouxii_CBS_732_zyro0g21868g, 256 Debaryomyces_hansenii_CBS767_deha2b16478g, 257 Debaryomyces_hansenii_CBS767_deha2g17402g, 258 Kluyveromyces_lactis_CLIB210_klla0c19272g, 259 Yarrowia_lipolytica_CLIB122_yali0f27709g, 260 Candida_glabrata_CBS138_cagl0b02079g, 261 Debaryomyces_hansenii_CBS767_deha2a03806g, 262 Kluyveromyces_lactis_CLIB210_klla0c00220g, 263 Kluyveromyces_thermotolerans_CBS6340_klth0g09504g, 264 Candida_parapsilosis_CDC_317_capa_05437, 265 Kluyveromyces_polysporus_DSM_70294_klpo_513.33, 266 'Lodderomyces elongisporus NRRL YB-4239 loel 05322', 267 Yarrowia_lipolytica_CLIB122_yali0b19250g, 268 Candida_albicans_SC5314_caal_a_19.1942, 269 'Candida albicans WO-1 caal b 04515', 270 Candida_dubliniensis_CD36_cadu_51060, 271 Kluyveromyces_thermotolerans_CBS6340_klth0b00110g, 272 Pichia_stipitis_CBS_6054_pist_igi16603948, 273 'Saccharomyces bayanus 623-6C saba a 676.52', 274 Saccharomyces_bayanus_MCYC_623_saba_b_c280_5966, 275 Saccharomyces_cerevisiae_S288C_sace0h00308g, 276 Saccharomyces_cerevisiae_EC1118_sace_b_1h21_0100g, 277 Saccharomyces_cerevisiae_JAY291_sace_c_03075, 278 'Saccharomyces cerevisiae RM11-1A sace d 04665', 279 Saccharomyces_cerevisiae_YJM789_sace_e_2345, 280 'Saccharomyces paradoxus NRRL Y-17217 sapa c38 10565', 281 Debaryomyces_hansenii_CBS767_deha2e15070g, 282 Saccharomyces_cerevisiae_S288C_sace0e00330g, 283 Saccharomyces_cerevisiae_EC1118_sace_b_1e8_0089g, 284 Saccharomyces_cerevisiae_JAY291_sace_c_05195, 285 'Saccharomyces cerevisiae RM11-1A sace d 04406', 286 Saccharomyces_cerevisiae_YJM789_sace_e_1433, 287 Saccharomyces_mikatae_IFO_1815_sami_a_c202_5644, 288 'Saccharomyces paradoxus NRRL Y-17217 sapa c356 5984', 289 Debaryomyces_hansenii_CBS767_deha2d01210g, 290 Saccharomyces_kluyveri_CBS3082_sakl0g06600g, 291 Yarrowia_lipolytica_CLIB122_yali0c06105g, 292 Kluyveromyces_lactis_CLIB210_klla0e09879g, 293 'Saccharomyces castelli NRRL Y-12630 saca 713.30', 294 Saccharomyces_kudriavzevii_IFO_1802_saku_c1947.4, 295 Yarrowia_lipolytica_CLIB122_yali0c02541g, 296 Debaryomyces_hansenii_CBS767_deha2a14696g, 297 Saccharomyces_kluyveri_CBS3082_sakl0b12716g, 298 Candida_parapsilosis_CDC_317_capa_03952, 299 'Lodderomyces elongisporus NRRL YB-4239 loel 04525', 300 Pichia_pastoris_GS115_pipa_3g03640, 301 'Saccharomyces bayanus 623-6C saba a 602.6', 302 Saccharomyces_bayanus_MCYC_623_saba_b_c633_10089, 303 Kluyveromyces_lactis_CLIB210_klla0a10439g, 304 'Saccharomyces castelli NRRL Y-12630 saca 514.3', 305 Saccharomyces_cerevisiae_JAY291_sace_c_05665, 306 Saccharomyces_kudriavzevii_IFO_1802_saku_c1886.4, 307 'Saccharomyces paradoxus NRRL Y-17217 sapa c345 7143', 308 Yarrowia_lipolytica_CLIB122_yali0a10593g, 309 Candida_dubliniensis_CD36_cadu_34690, 310 Candida_guilliermondii_ATCC_6260_cagu_04002, 311 'Saccharomyces bayanus 623-6C saba a 601.3', 312 Saccharomyces_bayanus_MCYC_623_saba_b_c68_15461, 313 Saccharomyces_cerevisiae_S288C_sace0h00198g, 314 'Candida tropicalis MYA-3404 catr 03958', 315 Yarrowia_lipolytica_CLIB122_yali0d05401g, 316 Yarrowia_lipolytica_CLIB122_yali0d20350g, 317 Candida_lusitaniae_ATCC_42720_calu_01670, 318 Candida_parapsilosis_CDC_317_capa_03962, 319 Kluyveromyces_lactis_CLIB210_klla0e14609g, 320 Pichia_pastoris_GS115_pipa_2g00050, 321 Candida_parapsilosis_CDC_317_capa_00064, 322 Pichia_pastoris_GS115_pipa_3g01745, 323 Yarrowia_lipolytica_CLIB122_yali0a14883g, 324 Kluyveromyces_polysporus_DSM_70294_klpo_543.44, 325 Kluyveromyces_lactis_CLIB210_klla0d19945g, 326 Yarrowia_lipolytica_CLIB122_yali0d22913g, 327 Candida_glabrata_CBS138_cagl0e04092g, 328 Candida_guilliermondii_ATCC_6260_cagu_05301, 329 Debaryomyces_hansenii_CBS767_deha2e02596g, 330 'Saccharomyces paradoxus NRRL Y-17217 sapa c290 9193', 331 Yarrowia_lipolytica_CLIB122_yali0f19118g, 332 'Candida tropicalis MYA-3404 catr 00078', 333 Kluyveromyces_thermotolerans_CBS6340_klth0c10120g, 334 Candida_parapsilosis_CDC_317_capa_02689, 335 Debaryomyces_hansenii_CBS767_deha2c05390g, 336 Saccharomyces_kluyveri_CBS3082_sakl0h16808g, 337 Candida_guilliermondii_ATCC_6260_cagu_03941, 338 Yarrowia_lipolytica_CLIB122_yali0a17149g, 339 Yarrowia_lipolytica_CLIB122_yali0d20196g, 340 Candida_dubliniensis_CD36_cadu_61510, 341 Candida_albicans_SC5314_caal_a_19.3444, 342 'Candida albicans WO-1 caal b 05224', 343 Saccharomyces_kluyveri_CBS3082_sakl0c05588g, 344 Candida_parapsilosis_CDC_317_capa_02690, 345 Eremothecium_gossypii_ATCC10895_ergo0g10076g, 346 Zygosaccharomyces_rouxii_CBS_732_zyro0g07414g, 347 'Lodderomyces elongisporus NRRL YB-4239 loel 03789', 348 Saccharomyces_mikatae_IFO_1815_sami_a_c1083_3691, 349 Saccharomyces_cerevisiae_YJM789_sace_e_1018, 350 Saccharomyces_kudriavzevii_IFO_1802_saku_c1927.9, 351 Saccharomyces_cerevisiae_S288C_sace0d07920g, 352 Saccharomyces_cerevisiae_EC1118_sace_b_1d0_3730g, 353 Saccharomyces_cerevisiae_JAY291_sace_c_00011, 354 'Saccharomyces cerevisiae RM11-1A sace d 00400', 355 'Candida tropicalis MYA-3404 catr 02833'; TREE Imported_tree_0 = 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END; BEGIN ASSUMPTIONS; TYPESET * UNTITLED = unord: 1 - 1263; END; BEGIN CODONS; CODESET * UNTITLED = universal: 1 - 1263; END; BEGIN MESQUITECHARMODELS; ProbModelSet * UNTITLED = 'Mk1 (est.)': 1 - 1263; END; Begin MESQUITE; MESQUITESCRIPTVERSION 2; TITLE AUTO; tell ProjectCoordinator; timeSaved 1386870513739; getEmployee #mesquite.minimal.ManageTaxa.ManageTaxa; tell It; setID 0 2376418558233936229; endTell; getEmployee #mesquite.charMatrices.ManageCharacters.ManageCharacters; tell It; setID 0 8987149627320591452; mqVersion 275; checksumv 0 3 1297109459 null getNumChars 1263 numChars 1263 getNumTaxa 355 numTaxa 355 short false bits 1048575 states 1048575 sumSquaresStatesOnly 2.767987162301682E15 sumSquares 2.767987162301682E15 longCompressibleToShort false usingShortMatrix false NumFiles 1 NumMatrices 1; mqVersion; endTell; getWindow; tell It; suppress; setResourcesState false false 261; setPopoutState 400; setExplanationSize 0; setAnnotationSize 0; setFontIncAnnot 0; setFontIncExp 0; setSize 1440 755; setLocation 0 22; setFont SanSerif; setFontSize 10; getToolPalette; tell It; endTell; desuppress; endTell; getEmployee #mesquite.trees.BasicTreeWindowCoord.BasicTreeWindowCoord; tell It; makeTreeWindow #2376418558233936229 #mesquite.trees.BasicTreeWindowMaker.BasicTreeWindowMaker; tell It; suppressEPCResponse; setTreeSource #mesquite.trees.StoredTrees.StoredTrees; tell It; setTreeBlock 1; toggleUseWeights off; endTell; setAssignedID 2612.1386868649495.3424910018351298830; getTreeWindow; tell It; setExplanationSize 30; setAnnotationSize 20; setFontIncAnnot 0; setFontIncExp 0; setSize 1179 688; setLocation 0 22; setFont SanSerif; setFontSize 10; getToolPalette; tell It; endTell; setActive; getTreeDrawCoordinator #mesquite.trees.BasicTreeDrawCoordinator.BasicTreeDrawCoordinator; tell It; suppress; setTreeDrawer #mesquite.trees.SquareTree.SquareTree; tell It; setNodeLocs #mesquite.trees.NodeLocsStandard.NodeLocsStandard; tell It; branchLengthsToggle off; toggleScale on; toggleBroadScale off; toggleCenter on; toggleEven on; endTell; setEdgeWidth 6; orientUp; setCornerMode Right_Angle 50; endTell; setBackground White; setBranchColor Black; showNodeNumbers off; showBranchColors on; labelBranchLengths off; centerBrLenLabels on; showBrLensUnspecified on; showBrLenLabelsOnTerminals on; setBrLenLabelColor 0 0 255; setNumBrLenDecimals 6; desuppress; getEmployee #mesquite.trees.BasicDrawTaxonNames.BasicDrawTaxonNames; tell It; setColor Black; toggleColorPartition on; toggleShadePartition off; toggleShowFootnotes on; toggleNodeLabels on; toggleCenterNodeNames off; toggleShowNames on; namesAngle ?; endTell; endTell; setTreeNumber 1; setDrawingSizeMode 0; toggleLegendFloat on; scale 0; toggleTextOnTree off; showWindow; endTell; desuppressEPCResponse; getEmployee #mesquite.trees.ColorBranches.ColorBranches; tell It; setColor Red; removeColor off; endTell; getEmployee #mesquite.ornamental.BranchNotes.BranchNotes; tell It; setAlwaysOn off; endTell; getEmployee #mesquite.ornamental.ColorTreeByPartition.ColorTreeByPartition; tell It; colorByPartition off; endTell; getEmployee #mesquite.ornamental.DrawTreeAssocDoubles.DrawTreeAssocDoubles; tell It; setOn on; setDigits 4; writeAsPercentage off; toggleCentred on; toggleHorizontal on; toggleWhiteEdges on; setFontSize 10; setOffset 0 0; endTell; getEmployee #mesquite.ornamental.DrawTreeAssocStrings.DrawTreeAssocStrings; tell It; setOn on; toggleCentred on; toggleHorizontal on; setFontSize 10; setOffset 0 0; endTell; getEmployee #mesquite.trees.TreeInfoValues.TreeInfoValues; tell It; panelOpen false; endTell; endTell; endTell; endTell; end;