#NEXUS BEGIN DATA; Title 'Alignment from "E2-TGF-162.nexus"'; DIMENSIONS NTAX=162 NCHAR=165; FORMAT DATATYPE=PROTEIN GAP=- ; MATRIX [1] 'Acropora digitifera Bmp2/4' VNYCQRHPLYVDF-SEVGWND--WIVAP-PGYQGFYCKGECPFPIA--DHLN---TTNHA IVQTLM--NSVN--P-N--N------V-PPACCVPT--TLDAISMLF-MNEH--SK---V V----LK-NYQDMVVDGCG------------------------CR [2] 'Acropora digitifera Gdf5-like' KDSCRRKPMHVDF-KQLGWSN--WVIAP-RGYSAYLCEGLCEFPID--DYLK---PTNHA TVQTIL--NSVA--P-T--L------A-PRACCSPN--KFSAISILY-IDKG---N---I I----YK-KYEDMVVERCG------------------------CK [3] 'Acropora digitifera Activin 2' QQECCRRMLYVNF-KKIGW-D--WIIFP-EGFHANFCDGTCNGIVD--P------FYSYP YLLQE---VSRAN-K-Q--E------R-VSICCTPT--KMSAISVLH-FNDD--ER---V M----KI-DVPNMRVDACG------------------------CF [4] 'Acropora digitifera Activin 1' QQECCRRKLYVNF-TAQRW-D--WIIHP-SGFSANYCDGRCQKPNISLTPEK---LSKHK TV------------P-I--K------N-ESICCSPS--KYSPFSMMF-YDG---TS---F R----KI-DMTEMKIEACS------------------------CS [5] 'Acropora digitifera Tgf3' HKECRRRWVYVQF-KKLRWN---WIIAP-SGYSANYCEGACSSVLH--IALE---PTNHA ILQNIL--HRMD----N--R------I-PSPSCVPT--KLHGISILY-RASD--RS---I A----LT-EYGGMVVSTCG------------------------CH [6] 'Acropora digitifera Nodal-related A' PSPCSRKDMMITS-SDFGKRDGLTLLHP-RVFNAYQCSGECSFKE----------KTNNS KLRALI--MRDNGHSIR---------E-SKSCCVPS--KLRSIVVMQ-RTAE--RN---Y L----IS-TLKNMIVESCT------------------------CY [7] 'Acropora digitifera Tgf2' VDRCSRRKLFVKF-RDLKFDK--WIIAP-RGFSAYYCVGTCPEIID--KGYS---PTNHA IIQNLL--HHRI--N-K--N------I-PAACCVPT--SLHSISMMY-FELD--GS---I V----LR-EYSGMVASTCG------------------------CR [8] 'Acropora digitifera Tgf4' AGKCGVRNLTIYF-KDLGWDK--WFIAP-KMYSSNYCGGTCLDRHN--TQI----MSNHA LVQLLV--HEKD--S-S--S------A-HAPCCVPN--SMSALSMLY-FGDSGQST---T K----KT-AYENARLSS---------------------------- [9] 'Acropora millepora Bmp2/4' VNYCQRHPLYVDF-SEVGWND--WIVAP-PGYQGFYCKGECPFPIA--DHLN---TTNHA IVQTLM--NSVN--P-N--N------V-PPACCVPT--TLEAISMLF-MNEH--SK---V V----LK-NYQDMVVDGCG------------------------CR [10] 'Acropora millepora Gdf5-like' KDSCRRKPMHVDF-KQLGWSN--WVIAP-RGYSAYLCEGLCEFPID--DYLK---PTNHA TVQTIL--NSVA--P-T--L------A-PRACCSPN--KFSAISILY-IDKG---N---I I----YK-KYEDMVVERCG------------------------CK [11] 'Acropora millepora Tgf5' DSQCRLQTFVSNF-SMIGMGY--MIISPRNPIRFAYCRGSCDMPFS--LDAG---DDSYV TADMLI--RHLAILNGLSLSDDEKDMF-KTSYCVPV--EYTSLRVVF-GTEK--G----V R----KK-LWIRAIPRKCG------------------------CR [12] 'Acropora millepora Nodal-related A' PSPCSRKDMMITS-SDFGKRDGLTLLHP-RVFNAYQCSGECSFKE----------KTNNS KLRALI--MRDNGHSIR---------E-SKSCCVPS--KLRSIVMMQ-RTAE--RN---Y L----IS-TLKNMIVESCT------------------------C- [13] 'Acropora millepora Activin 2' QQECCRRMLYVNF-KKIGW-D--WIIFP-EGFHANFCDGTCNGIVD--P------FYSYP YLLQE---VSRAN-K-Q--E------R-VSICCTPT--KMSAISVLH-FNDD--ER---V M----KI-DVPNMRVDACG------------------------C- [14] 'Acropora millepora Activin 1' QQECCRRKLYVNF-TAQSW-H--WIIHP-SGFSANYCDGRCQKPNISLTREK---LSKHR TV------------P-I--K------N-ESICCSPS--KYSPFSMMF-YDG---TS---F R----KI-DMTEMKIEACS------------------------C- [15] 'Acropora millepora Nodal-related B' GP-CSRRPMTVHF-RAHLNMK--QVIFP-RTFESYRCGGSCKFPLD----VN---PTRHA IILAIL--YSRS-GRAG--G------G-KEPCCVPI--KLRKMTVFA-RRE---GH---I K----IQ-TFQDMIVEECG------------------------CR [16] 'Acropora millepora Tgf2' VDRCSRRKLFVKF-RDLRFDK--WIIAP-RGFSAYYCVGTCPEIID--KGYS---PTNHA IIQNLL--HHRI--N-K--N------I-PAACCVPT--SLHSISMMY-FELD--GS---I V----LR-EYSGMVASTCG------------------------CR [17] 'Acropora millepora Tgf4' AGKCGVRNLTIYF-KDLGWDK--WFIAP-KMYSSNYCGGTCLDRHN--TQI----MSNHA LVQLLV--HEKD--S-S--S------A-HAPCCVPN--SMSALSMLY-FGDSGQST---Y V----LK-TVDGFIVRSCA------------------------CR [18] 'Acropora millepora Tgf3' HKECRRRWVYVQF-KKLRWN---WIIAP-SGYSANYCEGACSSVLH--IALE---PTNHA ILQNIL--HRMD----N--R------I-PSPSCVPT--KLHGISILY-RASD--RS---I A----LT-EYGGMVVSTCG------------------------C- [19] 'Acropora millepora Tgf1' LDICRKRRHAVRF-RDLKWNG--WIIAP-TRFGFHYCEGICSATLS--QEYN---PSNHA ILQNIL--HHRL--T-S--E------I-PAATCVPI--ELHSMSLLY-YDTD--NT---I V----LR-EVPEMVASNCG------------------------CR [20] 'Branchiostoma floridae Activin' SNECCREKFYVDF-KDIAWDD--WIISP-KGYYANFCTGSCQGTIL--P------RYHHT SVLQRV--ALSQKDR-ETRL------K-LTPCCTPT--KMSALSMLY-FDND--GY---I F----NK-NLPNMKVDACG------------------------CS [21] 'Branchiostoma floridae Admp' FEPCTRRNLYVDF-DAIGWSG--WIISP-KGYNAYHCKGKCPFPLG--QSQK---PTNHA TVQSIM--NALRL-Q-E--D------V-GQPCCVPN--KLYSINLLY-FDDE--EN---V I----LK-QYDDMVAANCG------------------------CH [22] 'Branchiostoma floridae Bmp2/4' KANCRRHSLYVDF-SDVGWND--WIVAP-PGYQAYYCHGECPFPLA--DHLN---STNHA IVQTLV--NSVN--P-L--A------V-PKACCVPT--DLSPISMLY-LNEN--DQ---V V----LK-NYQDMVVEGCG------------------------CR [23] 'Branchiostoma floridae Tgf1' CKSCKRHSLYVDF-TELGWG---WIIAP-AGYTAYYCKGHCPPIMG--QHLR---PTNHA VVQNIM--GTLH--P----R------V-PPARCVPG--MLRPISVLH-YEEN--GS---I I----YK-EYPDMVAMSCA------------------------CR [24] 'Branchiostoma floridae Bmp3' --------MRVDF-ADIGWSD--WIISP-KAFDAYYCAGTCDFPMS--KVMK---PSNHA TIQSIM--RTVGI-T-S--G------V-PSPCCVPD--KLSSLSILY-FDEN--RN---V V----LK-VYPNMSVESCA------------------------CR [25] 'Branchiostoma floridae Bmp5-8' PHVCQRRSLYVSF-RDLGWQD--WIIAP-DGYAAYYCFGECSFPLN--ALMN---ATNHA IVQTLV--HLMN--P-Q--H------V-PKPCCAPI--KLSAISVLY-FDES--SN---V I----LK-KYRNMVVKSCG------------------------CH [26] 'Branchiostoma floridae Nodal-related' VEECRRHDYHVVF-DDIILPE--FILQP-PRFNAYRCGGACTRPFP--SHMN---ATNHA MLMSLL--HERT--PHK---------V-PAPCCVPL--AYSAISVME-QHG---DN---I V----VK-PYPNMRVETCG------------------------CR [27] 'Branchiostoma floridae Gdf5-7' ---CMRRSLQVSF-HDLGWDD--WIIAP-TNYDAHYCAGACSFPLR--SHLE---PTNHA IVQTLV--NSMN--P-R--A------V-EKVCCVPT--KLSPISILY-IDGK--DT---V V----YK-KYDDMVADQCG------------------------CR [28] 'Branchiostoma floridae Gdf8/Tgfb-like' PRSCCRRSLVVSF-KDIGWDG--WVMEP-AEFDAHYCLGQCASYNL---------PSPHA AIMDQV----VS--P-V--Y------E-MKPCCVPVPGQMRDLLIRYSFDGG--KT---I S----TQ-HIPNIIVNTCG------------------------CL [29] 'Branchiostoma floridae Lefty' SNRCCRSENYIDF-SDLPFAEQ-FILEP-RGYDAFQCGGGCPKRA----------RW-YM HNDPEQ----------------------LQQTCGVV--RTAPLPVMY-LVSR--GDKTEI E----VA-DFPNMIVEQCA------------------------CT [30] 'Branchiostoma floridae Myostatin' EERCCRYPLQVDF-REFGW-D--WIIAP-NTYQAYYCAGDCPPIFL-----Q---KYPHT HLVQQV--NK--A------G------S-VGPCCTPT--KMSNISMLY-FDDD--GN---I I----YA-KLPDMKVDRCG------------------------CS [31] 'Branchiostoma floridae Nodal' TP-CKKVEFWVDF-DHIGWGT--WIIYP-KRFNAFRCEGVCPTPVD--QLYH---PTNHA VMTSIL--NLHK--P-G--K------A-PMPCCIPT--KLKALSMLY-LEH---GE---V V----LR-HHEDMIVDECG------------------------CQ [32] 'Branchiostoma floridae Univin' GNICKRRKLYIRF-KDVGWDD--WIIAP-QGYMAYHCSGECPFPLN--EHLN---GTNHA VIQTLV--NSLT--P-D--S------V-PPACCAPT--KWSSISMLY-FDNN--GD---V V----LR-QYEDMVVDGCG------------------------CR [33] 'Biomphalaria glabrata Nodal' KVNCQLHNFEVDF-NTIGWGQ--WIIHP-KKYNAQFCFGVCPSPVD--SKYK---PTNHA MLQTLM--RLKR--P-N--V------A-PAPCCVPT--RLNPLSMMY-YEF---NE---L V----VR-HHEDMIATECG------------------------CR [34] 'Cladonema pacificum Gdf8/Tgfb-like' SSDCCLDNFYVSF-KAIGD----WIRNP-VGYNAQQCRGRCNS-----RHPK---SNPHR SMVSAI--STRRNIT----D------D-IKFCCTTQ--AYAPLKISY-QDFE--GN---I V----HQ-SLTNMIATQCG------------------------CG [35] 'Cladonema pacificum Bmp5-8' NASCGRRPLYIGF-KDLGWND--WILAP-AGYRAAYCDGECGFPLH--DKMN---ASNHA IIQTLV--HMIN--P-D--H------I-PQPCCAPV--RLEPLKVLY-LDER--SN---I I----MK-TYGNMIVKHCG------------------------CQ [36] 'Cladonema pacificum Bmp2/4' KEKCRLRNFFLDF-KDVAWDE--WIIAP-TGYYINYCHGVCPKPLG--PHYN---TTNHA VIQNSV--SNIN--R-N--L------V-PPLCCIPT--TLKDQTFLY-LDDH--GS---L I----IK-NPIDMVAMGCG------------------------CH [37] 'Cladonema pacificum Nodal-related' KKMCRRKNMVVDF-QELGWGN--WLLSP-TKYNAYHCHGHCRYPLA--TYLR---PTNHA TIQSIV--HNMN--R-D--F------V-PSACCVPT--DFDVLPILS-LDGK--DR---V V----FK-LKSGLVATNCG------------------------CR [38] 'Drosophila melanogaster Dpp' DDTCRRHSLYVDF-SDVGWDD--WIVAP-LGYDAYYCHGKCPFPLA--DHFN---STNHA VVQTLV--NNMN--P-G--K------V-PKACCVPT--QLDSVAMLY-LNDQ--ST---V V----LK-NYQEMTVVGCG------------------------CR [39] 'Drosophila melanogaster Myoglianin' DMRCCRYPLKVNF-TSFGWH---FVVAP-TSFDAYFCSGDCKVGYL-----E---QYPHT HLAALT-------------T------S-ATPCCSPT--KMSSLSLLY-FDDN--HN---L V----LS-VIPNMSVEGCS------------------------CS [40] 'Danio rerio InhibinbA' ARVCCKRQFYVNF-KDIGWND--WIIAP-SGYHANYCEGDCASNVASITGNS---LSFHS TVISHY--RIRGYSP-F--T------N-IKSCCVPT--RLRAMSMLY-YNEE--QK---I V----KK-DIQNMIVEECG------------------------CS [41] 'Danio rerio Admp' KMACQRQPLYVDF-EEIGWSG--WIVSP-KGYNAYHCKGSCIFPLS--QNMR---PTNHA IVQSII--NTLKL-N-K--G------I-QTPCCVPD--KLYSISLLY-FDDD--EN---V V----LK-QYDDMVAGSCG------------------------CR [42] 'Danio rerio Bmp10' GNQCKKSSLYVDF-KDIGWDS--WILAP-TGYEAFECTGVCTYPLT--KDVT---PTKHA VIQTLV--SLKS--P-Q--V------V-SRACCVPT--ELDPISLLY-LDDA--GV---V T----YQYKFEGMVVAKCG------------------------CR [43] 'Danio rerio Bmp2a' KANCRRHSLYVDF-SDVGWND--WIVAP-PGYHAFYCQGECPFPLA--DHLN---STNHA IVQTLV--NSVN----S--N------I-PRACCVPT--DLSPVSLLY-LDEY--ER---V I----LK-NYQDMVVEGCG------------------------CR [44] 'Danio rerio Bmp3' PRNCARRYLKVDF-ADIGWSE--WIISP-KSFDAYYCSGSCQFPMP--KSLK---PSNHA TIQSIV--RAVGV-V-P--G------I-PEPCCVPE--KMSSLSILF-FDED--KN---V V----LK-VYPNMTVDSCA------------------------CR [45] 'Danio rerio Bmp4' NRNCRRHALYVDF-SDVGWND--WIVAP-PGYQAYYCHGECPFPLA--DHLN---STNHA IVQTLV--NSVN----T--N------I-PKACCVPT--ELSAISMLY-LDET--DR---V V----LK-NYQEMVVEGCG------------------------CR [46] 'Danio rerio Bmp5' RQACKKHELYVSF-RDLGWQD--WIIAP-EGYAAFYCDGECSFPLN--AHMN---ATNHA IVQTLV--HLMF--P-D--N------V-PKPCCAPT--KLNAISVLY-FDDS--SN---V I----LK-KYRNMVVRSCG------------------------CH [47] 'Danio rerio Bmp6' KTACRKHDLYVSF-RELSWQD--WIIAP-EGYAANYCDGECSFPLN--AHMN---ATNHA IVQTLV--HLMN--P-E--N------V-PKPCCAPT--KLHAISVLY-YDDN--SN---V I----LK-KYRNMVVRSCG------------------------CH [48] 'Danio rerio Bmp7' KQACKKHELYVSF-RDLGWQD--WIIAP-EGYAAYYCMGECAFPLN--SYMN---ATNHA IVQTLV--HFIN--P-E--T------V-PKPCCAPT--QLHAISVLY-FDDS--SN---V I----LK-KYRNMVVRACG------------------------CH [49] 'Danio rerio Gdf11' ESRCCRYPLTVDF-EAFGW-D--WIIAP-KRYKANYCSGQCEYMFM-----Q---KYPHT HLVQHA-------NP-R--G------S-AGPCCTPT--KMSPINMLY-FNDK--QQ---I I----HG-KIPGMVVDRCG------------------------CS [50] 'Danio rerio Gdf5' KQRCNRKQLHVNF-KEMGWDD--WIIAP-LEYEAFHCDGVCDFPIR--SHLE---PTNHA IIQTLM--NSMD--P-R--S------T-PPTCCVPT--RLSPISILY-IDSA--NN---V V----YK-QYEDMVVESCG------------------------CR [51] 'Danio rerio Gdf6A' KSRCSKKALHVNF-KELGWDD--WIIAP-LDYEAYHCEGVCDFPLR--SHLE---PTNHA IIQTLM--NSMD--P-N--S------T-PPSCCVPT--KLSPISILY-IDSG--NN---V V----YK-QYEDMVVEQCG------------------------CR [52] 'Danio rerio Gdf7' RTRCSRKPLHVNF-KELGWDD--WIIAP-LDYEAYHCEGLCDFPLR--SHLE---PTNHA IIQTLM--NSMD--P-E--S------T-PPSCCVPS--KLSPISILY-IDSG--NN---V V----YK-QYEDMVVESCG------------------------CR [53] 'Danio rerio Gdf8' ESRCCRYPLTVDF-EDFGW-D--WIIAP-KRYKANYCSGECDYMYL-----Q---KYPHT HLVNKA-------SP-R--G------T-AGPCCTPT--KMSPINMLY-FNGK--EQ---I I----YG-KIPSMVVDRCG------------------------CS [54] 'Danio rerio Lefty1' REMCCREQYFINF-RALTWTQY-WIIEP-SGYQAFRCKGGCRQPK----------R-N-Y GY--------------------------GERKCAVV--ESAPLPMMY-LVKK--GDYTEI E----VA-EFPNMIVEKCG------------------------CA [55] 'Danio rerio Nodal-related' KPLCKKVDMWVDF-DQIGWSD--WIVYP-KRYNAYRCEGSCPTPVD--ETFT---PTNHA YMQSLL--KLHH--P-D--R------V-PCLSCVPT--RLAPLSMLY-YEN---GK---M V----MR-HHEGMVVAECG------------------------CH [56] 'Danio rerio Tgfb2' QDNRCLRSLYIDFKKDLGWR---WIHEP-KGYNANFCAGACPYLWS-----A---DTQHS NILGLY--NTIN--P-E--A------S-ASPCCVSQ--DLEPLTILY-YIGK--TP---- K----IE-QLSNMIVKSCK------------------------CS [57] 'Danio rerio Tgfb3' EENCCVRKLYIDFRQDLGWR---WIHEP-KGYHANFCSGPCPYLRS-----A---DTTHS SLLSLY--NTLN--P-E--A------S-ASPCCVPQ--DLEPLTILY-YVGR--TP---- K----VE-QLSNMIVKSCK------------------------CS [58] 'Danio rerio Vgr1' SNVCKPRRLYIDF-KDVGWQD--WIIAP-QGYLANYCHGECPFPLS--ESLN---GTNHA ILQTLV--HSFD--P-K--G------T-PQPCCVPI--KLSPISMLY-YDNN--DN---V V----LR-HYEDMVVDECG------------------------CR [59] 'Gallus gallus Nodal' RSLCRRVDMMVDF-EQTGWGS--WIVYP-KKYNAYRCEGLCPSPVD--ESFK---PTNHA YMQSLL--QLYK--P-S--Q------V-PCPACSPI--RMSPLSMLY-YEK---GE---I V----VR-HHEDMIIEECG------------------------CN [60] 'Hydra magnipapillata Activin-like 1' SEECCRSSITINF-KDLGWES--WILAP-KTYEAYYCTGTCKENSN----------TNPP HFQLLR--SNNN----------------KGKCCVPK--SMSSLAILY-VGSE--G----I I----KK-DLPNMIVDECW------------------------CI [61] 'Hydra magnipapillata Activin-like 2' DASCCSRPVYVSF-EDLSWN---WVLSP-KGFWTNKCMGNCKDNKQ-------------- --------------------------G-INNCCIPI--EHESITMFY-YDND--YI---F Y----AK-KVNNIVTKECG------------------------CR [62] 'Hydra magnipapillata Activin-like 3' DASCCSRPFYVSF-QDLKWN---WVLSP-KGFWTNKCMGKCKDGNL-------------- --------------------------N-NSGCCAPK--SFGSITMFY-HNGD--YI---L Y----GK-KIENIVTKDCG------------------------CL [63] 'Hydra magnipapillata Tgf4' AKVCGVEPLNVPL-ELIDWQK--LFIYP-THFIINHCKGFCYHKND--KDNDE--QTSHS ILQALY--ADVL--QND--I------V-KYPCCAPT--KFLPGTALI-IDRS--SVNEVI K----LV-QLENLTVTECK------------------------CL [64] 'Hydra magnipapillata Tgf3' SKLCGVEPLVVPL-ELIDWHN--LFIMP-KSFSINQCKGRCFHKND-EDYLG---QTSHS ILQALY--ADVL--QDD--N------V-NYPCCAPT--KFLPASAIL-NDRS--SNREVY K----LV-QLENLQVTECE------------------------CL [65] 'Hydra magnipapillata Bmp2/4' QDLCHLHPFEFDL-VKVGWNE--FVLYP-SLYRLNFCAGKCPNPLS--HHFN---GTNHA VIQNNV--LKIA--K-D--K------V-PPLCCIPS--ELEAQTIIY-IDHE--NK---M I----IK-RPEKMIATACG------------------------CR [66] 'Hydra magnipapillata Bmp5-8a' ISDCGKHLLYVSF-KDIGWSD--WIIAP-DGYITSYCGGDCSFPLE--SNLN---ATNHA ILQALV--HTIF--P-K--K------I-PKPCCAPN--KLNAMSILF-FDDR--NN---V V----MQ-EIPNMIVHQCG------------------------CQ [67] 'Hydra magnipapillata Bmp5-8b' GSRCDKHSLYIRF-KDIGWN---LIIAP-EGYEANYCGGECSFPLD--NNAS---ATNHA TIQTLV--HMMF--P-E--I------I-PKPCCAPN--KLKRLKVLF-EDER--HN---V V----LS-HFPNMIVQHCG------------------------CQ [68] 'Hydra magnipapillata Bmp5-8c' GSRCDKHPLYIGF-KDLGWSD--WIIAP-DGYRANYCGGDCSFPLD--NNAN---ATNHA IIQTLV--HMMY--P-E--I------I-PKPCCAPN--KLNTLQVLF-LDER--NN---V V----MK-RYSNMIVQHCG------------------------CQ [69] 'Hydra magnipapillata Activin-like 4' SVSCCSRPVYISF-EDINWR---WVLSP-KGFWTNKCMGKCDKENP-------------- --------------------------D-KSTCCAPL--TLGSITMYY-HNGD--YL---V Y----GK-KLENIVIKDCG------------------------CQ [70] 'Hydra magnipapillata Nodal-related' K-KCRRKSMKVNL-SELKWDK--WFMNP-IKFNAYYCHGSCAHPL---T-VT---TDNHA TIQSMM--HKLN--T-K--I------V-GPPCCVPT--EYEKLLVLY-MQE---NN---P T----IR-LINGLIVKACG------------------------CK [71] 'Hydra magnipapillata Tgf1' NVGCRKKNMFFKF-RDYSEFS--NVLIP-KKANFYRCVGSCTIPFGKNSKIM---KSTRA FIQELI--SSRQ-KGVK--P------M-HLPTCSPS--SLKPMKYII-FEN---EK---V K----IG-SWDDAVVSECWSITIIFMFINHNDVIYLFQYMSISCK [72] 'Hydra magnipapillata Tgf2' KNICSVKQLFVPL-KKAGWNN--LFLYP-DHFIINQCKGQCYIK-----------KTYHS ILQTLY--ADVL--KNH--E------V-KHPCCAPS--KLLPGTALI-YDHS--SGKKVF N----LV-RIHNLTVTQCE------------------------CL [73] 'Lottia gigantea Tgf2' TGQCCKLPSFVNF-SDLGLDD--RIVTP-NGYMTGSCIGRCPRTRH-----N---GRRNN RDQTQI--------PTERSR------S-RRSRCKPA--ETSSLTVLL-FNEN--HD---L M----QA-ELSGLVVNSCT-------------------------- [74] 'Lottia gigantea Admp' KRSCTKQDMYVDF-DEIGWSG--WIISP-KGYNANHCTGTCPFPLG--QSQK---PTNHA TVQSIV--YALGV-G-K--S------V-ETPCCVPN--KLYSISLLY-FDDD--EN---V I----LK-QYDDMVAATCG------------------------CH [75] 'Lottia gigantea Bmp2/4' KNECKRHALYVDF-GDVGWND--WIVAP-TGYNAYFCRGECPFPMG--QHLN---STHHA VMQTLV--HSVN--P-S--A------V-PKACCVPS--ELSAISMLY-LDEW--DK---V V----LK-NYQDMVVEGCG------------------------CR [76] 'Lottia gigantea Bmp5-8' NLPCKRHSLYVSF-RDLGWQD--WIIAP-DGYSAFYCHGECSFPLA--ANMN---ATNHA IVQTLV--HLMD--P-V--L------V-PKPCCAPT--KLNAISVLY-FDAN--SN---V V----LK-KYKSMIVKSCG------------------------CH [77] 'Lottia gigantea Tgf1' EISCCREPVLFNF-EEAGLG---WIIAP-TGFYTSECAGSCHAHNG----------VRTS SG------------------------MTIEHSCRPN--NRKPLSVLY-ITKS--LN---I R----LG-LLPGIVVMDCS------------------------CQ [78] 'Lottia gigantea Myostatin' EKRCCRHPLEVDF-VDFGWD---WVIAP-IRYKAGYCNGECDSTYQ-----D---EYAHT YLRQRA--SLTS----------------DGPCCTPT--QHKPLSLLY-FDHD--QN---I L----FT-ELQNMKVMKCG------------------------CA [79] 'Lottia gigantea Tgf3' ESRCCRNVVKIKA-QDIFP----QIIAP-DEFELTFCSGSCDDPMI--SPVN-----NYT RMIQSFRWRTGDELLRN---------A-IHFCCAPI--AFRAQSILL-YKA---GN---I I----KY-DIPDLIPTACG------------------------CI [80] 'Lottia gigantea Nodal' NSGCQLHDFEVDF-NSIGWGQ--WIIHP-KKFNARFCYGECASPID--VKYK---PTNHA MLQTLM--RSKR--K-N--S------A-PPACCVPT--KLNPLSMLY-YEF---DE---I V----VR-HHEEMIASECG------------------------CR [81] 'Lymnaea stagnalis Nodal' KENCQLHNFEVDF-NTIGWGQ--WIIHP-KKFNSRFCFGVCPSPID--VKYK---PTNHA MLQALM--RMKK--P-N--I------A-PVPCCVPS--KLNALSMMY-FEY---NE---L V----VR-HHEDMIAEECG------------------------CR [82] 'Mnemiopsis leidyi Tgf1b' AFPRQKVKFDLNL-VDIGWDS--WMLIP-KMVDIGICQGTCNDMTA---------LILHA MAKHKI--SQVM--PNE--R------I-GQICCQEA--SYREIVALY--QVD--GS---L V----KS-ILPQFVVSSCK------------------------CR [83] 'Mnemiopsis leidyi Tgf4' GEKCKLEPLYINF-RDLGWES--WVIAP-PGLEVGSCSGYCMREDI---------SSNYN LLINNI-----SRDPELYRLYGLAGIR-TERTCVPT--SFLPTVLMF-IGKD--QD---I V----VQ-LVDDILVGGCG------------------------CV [84] 'Mnemiopsis leidyi Myostatin' QKKCCRYHYFVKF-ADLGMD---WILAP-DGYDAYYCSGDCPFMYL-AEQKS---SLYYT FVIARA--NYNN--P-M--A------S-PRPCCTPA--SLSDLSIMF-SSGK--VDSTGQ PLDVEIH-NLEDMVVDECG------------------------CS [85] 'Mnemiopsis leidyi TgfbA' PRQCCKKDHWITF-KEVGLDH--IILEP-QAYNAGLCLGVCNEMWL--E------QFYHS HIMSLS--DNVQ----------------ARNCCAPA--SVDSLRIIY-YDEE--NDTHKF E-------TLPNMQVTECG------------------------CK [86] 'Mnemiopsis leidyi Tgf2' QHRCTMMEFYVNF-TKLGWGS--KIIHP-QIEKINQCAGQCPYPMS--HAID---HTTNA LFRGAW--SKQF--P-G--S------V-ARPCCVPA--EYKPATLML-MQG---PV---T I----LK-IFDDLIITKCK------------------------CL [87] 'Mnemiopsis leidyi Nodal-related' SPHCRVRNLMVNF-NKIGLN---SVMAP-LEFNAHICSGQCHLDHE--E-TP---MTNHA FIQNML--YLSG--TGE--E------V-QGASCVSD--KMKPLSVLI-AAG---RD---F Q----LT-VYEDMVVDSCS------------------------CR [88] 'Mnemiopsis leidyi Tgf3' EGKCGVRLLYLQF-EKDMSIP--SIRAP-QGVYVNYCSGSCPYLWK---TEN---PPLHT LILGQYAEQIRE-------S------R-YEPCCLPA--TYEAAEAIT-VENQ-------I I-------KFEDLRVTSCK------------------------CV [89] 'Mnemiopsis leidyi Tgf1a' NYHCRRQDLWINF-DEIGWD---FVITP-KDVNIGDCGGQCLDADS---------NIPHA VVKQLL--QKMH--PAR---------NAGILCCQGA--NYKEISALY-FKSK--HE---I V----IG-DMPKIIVKECR------------------------CR [90] 'Mus musculus InhibinbA' VNICCKKQFFVSF-KDIGWND--WIIAP-SGYHANYCEGECPSHIAGTSGSS---LSFHS TVINHY--RMRGHSP-F--A------N-LKSCCVPT--KLRPMSMLY-YDDG--QN---I I----KK-DIQNMIVEECG------------------------CS [91] 'Mus musculus InhibinbB' TSLCCRQQFFIDF-RLIGWND--WIIAP-TGYYGNYCEGSCPAYLAGVPGSA---SSFHT AVVNQY--RMRGLNP----G------P-VNSCCIPT--KLSSMSMLY-FDDE--YN---I V----KR-DVPNMIVEECG------------------------CA [92] 'Mus musculus Bmp10' GNYCKKTPLYIDF-KEIGWDS--WIIAP-PGYEAYECRGVCNYPLA--EHLT---PTKHA IIQALV--HLKN--S-Q--K------A-SKACCVPT--KLDPISILY-LDK---GV---V T----YKFKYEGMAVSECG------------------------CR [93] 'Mus musculus Bmp2' KSSCKRHPLYVDF-SDVGWND--WIVAP-PGYHAFYCHGECPFPLA--DHLN---STNHA IVQTLV--NSVN----S--K------I-PKACCVPT--ELSAISMLY-LDEN--EK---V V----LK-NYQDMVVEGCG------------------------CR [94] 'Mus musculus Bmp3' PRNCARRYLKVDF-ADIGWSE--WIISP-KSFDAFYCSGACQFPMP--KSLK---PSNHA TIQSIV--RAVGV-V-S--G------I-PEPCCVPE--KMSSLSILF-FDEN--KN---V V----LK-VYPNMTVDSCA------------------------CR [95] 'Mus musculus Bmp4' NKNCRRHSLYVDF-SDVGWND--WIVAP-PGYQAFYCHGDCPFPLA--DHLN---STNHA IVQTLV--NSVN----S--S------I-PKACCVPT--ELSAISMLY-LDEY--DK---V V----LK-NYQEMVVEGCG------------------------CR [96] 'Mus musculus Bmp5' KQACKKHELYVSF-RDLGWQD--WIIAP-EGYAAFYCDGECSFPLN--AHMN---ATNHA IVQTLV--HLMF--P-D--H------V-PKPCCAPT--KLNAISVLY-FDDS--SN---V I----LK-KYRNMVVRSCG------------------------CH [97] 'Mus musculus Bmp6' KTACKKHELYVSF-QDLGWQD--WIIAP-KGYAANYCDGECSFPLN--AHMN---ATNHA IVQTLV--HLMN--P-E--Y------V-PKPCCAPT--KLNAISVLY-FDDN--SN---V I----LK-KYRNMVVRACG------------------------CH [98] 'Mus musculus Bmp7' RQACKKHELYVSF-RDLGWQD--WIIAP-EGYAAYYCEGECAFPLN--SYMN---ATNHA IVQTLV--HFIN--P-D--T------V-PKPCCAPT--QLNAISVLY-FDDS--SN---V I----LK-KYRNMVVRACG------------------------CH [99] 'Mus musculus Gdf1' VGTCRTRRLHVSF-REVGWHR--WVIAP-RGFLANFCQGTCALPET-LRGPGGPPALNHA VLRALM--HAAA--PTP--G------A-GSPCCVPE--RLSPISVLF-FDNS--DN---V V----LR-HYEDMVVDECG------------------------CR [100] 'Mus musculus Gdf11' ESRCCRYPLTVDF-EAFGW-D--WIIAP-KRYKANYCSGQCEYMFM-----Q---KYPHT HLVQQA-------NP-R--G------S-AGPCCTPT--KMSPINMLY-FNDK--QQ---I I----YG-KIPGMVVDRCG------------------------CS [101] 'Mus musculus Gdf3' RNFCHRHQLFINF-QDLGWHK--WVIAP-KGFMANYCHGECPFSMT--TYLN---SSNYA FMQALM--HMAD--P-K---------V-PKAVCVPT--KLSPISMLY-QDSD--KN---V I----LR-HYEDMVVDECG------------------------CG [102] 'Mus musculus Gdf5' KARCSRKALHVNF-KDMGWDD--WIIAP-LEYEAFHCEGLCEFPLR--SHLE---PTNHA VIQTLM--NSMD--P-E--S------T-PPTCCVPT--RLSPISILF-IDSA--NN---V V----YK-QYEDMVVESCG------------------------CR [103] 'Mus musculus Gdf6' RLRCSRKPLHVNF-KELGWDD--WIIAP-LEYEAYHCEGVCDFPLR--SHLE---PTNHA IIQTLM--NSMD--P-G--S------T-PPSCCVPT--KLTPISILY-IDAG--NN---V V----YK-QYEDMVVESCG------------------------CR [104] 'Mus musculus Gdf7' RSRCSRKSLHVDF-KELGWDD--WIIAP-LDYEAYHCEGVCDFPLR--SHLE---PTNHA IIQTLL--NSMA--P-D--A------A-PASCCVPA--RLSPISILY-IDAA--NN---V V----YK-QYEDMVVEACG------------------------CR [105] 'Mus musculus Gdf8' ESRCCRYPLTVDF-EAFGW-D--WIIAP-KRYKANYCSGECEFVFL-----Q---KYPHT HLVHQA-------NP-R--G------S-AGPCCTPT--KMSPINMLY-FNGK--EQ---I I----YG-KIPAMVVDRCG------------------------CS [106] 'Mus musculus Lefty1' GTRCCRQEMYLDL-QGMKWAEN-WILEP-PGFLTYECVGSCLQLPE--------SLTSRW PFL-------------------------GPRQCVAS--EMTSLPMIV-SVKE--GGRTRP Q----VV-SLPNMRVQTCS------------------------CA [107] 'Mus musculus Nodal' SQLCRRVKFQVDF-NLIGWGS--WIIYP-KQYNAYRCEGECPNPVG--EEFH---PTNHA YIQSLL--KRYQ--P-H--R------V-PSTCCAPV--KTKPLSMLY-VDN---GR---V L----LE-HHKDMIVEECG------------------------CL [108] 'Mus musculus Tgfb1' EKNCCVRQLYIDFRKDLGWK---WIHEP-KGYHANFCLGPCPYIWS-----L---DTQYS KVLALY--NQHN--P-G--A------S-ASPCCVPQ--ALEPLPIVY-YVGR--KP---- K----VE-QLSNMIVRSCK------------------------CS [109] 'Mus musculus Tgfb2' QDNCCLRPLYIDFKRDLGWK---WIHEP-KGYNANFCAGACPYLWS-----S---DTQHT KVLSLY--NTIN--P-E--A------S-ASPCCVSQ--DLEPLTILY-YIGN--TP---- K----IE-QLSNMIVKSCK------------------------CS [110] 'Mus musculus Tgfb3' EENCCVRPLYIDFRQDLGWK---WVHEP-KGYYANFCSGPCPYLRS-----A---DTTHS TVLGLY--NTLN--P-E--A------S-ASPCCVPQ--DLEPLTILY-YVGR--TP---- K----VE-QLSNMVVKSCK------------------------CS [111] 'Nematostella vectensis Activin' MRECCRQEFYVSF-EEMGWDN--WILVP-RGFNANYCTGSCYGHIL--P------VYHHT EVIQKVA-LLRKQR-----E--------LSPCCAPT--KMFDLSLLY-YDKD--EN---L F----QE-NVSNMVVEECG------------------------CS [112] 'Nematostella vectensis Bmp2/4' PQYCQRHPLYVDF-TDVGWND--WIVAP-PGYHAFYCTGVCPYPIA--KHLN---ATNHA IVQTIM--NTVD----S--N------V-PNACCIPT--TLNPISILS-LNEF--DK---V V----LK-NYKDMVIEGCG------------------------CR [113] 'Nematostella vectensis Bmp5-8' KKVCQRQALHVSF-RKLRWQD--WVIAP-EGYSAFYCSGECSFPLN--ANMN---ATNHA IVQTLV--HLMN--P-K--T------V-PKPCCAPT--ELSPISVLY-FDQD--NN---V V----LK-KYNKMVVKACG------------------------CH [114] 'Nematostella vectensis Gdf5-like' KRKCRRKRMYVDF-RLLGWSD--WIIAP-QGYDAYLCEGECKYPID--NYLR---PTNHA TVQTIV--NSLD--P-S--I------A-PKACCTPN--ELSPISILY-TEDGS-NN---V V----YK-NYKDMVVERCG------------------------CS [115] 'Nematostella vectensis Gdf8' ERRCCRYELTVDF-EKFSWN---WIIAP-KRFRAYYCTGECQEIML-----P---MYPHA HMVKKS-------------T------G-KRPCCSPT--KMSSISMIY-FDFN--QQ---I M----FE-EVPAMVAETCG------------------------CT [116] 'Oscarella carmela Tgf3' EDVCKRHPLLVNF-TDVGWF---HIIHP-PVVDIGVCSGVCGSLEK---VYH---NSVHA EVLAIL--RARTKGKESNRK------QKPGPSCTPM--TFKAIKVKR-RLGN--TT---- -----FDGVIPRLVVESCM------------------------CS [117] 'Oscarella carmela Tgf2' NKVCRRKKLNFSF-VEMAWGN--WIVAP-LVFDGGVCRGECRAPLT--HATN---NTNHA IMQSLL--ARGS----K--K------M-PKVPCAPI--SFKPLKILF-YDSD--NS---L K----YV-FYKQSSVAVCG------------------------CR [118] 'Oscarella carmela Activin-like' QERCCRMPLTITL-EDLGWSS--WVFAP-SEFEAFFCKGSCPKHYK-----P---ASRHA SITSLL--AGKY----KRYR------K-GNRCCSPT--SLSSVTLIH-FSNS--GE---I T----ST-EFENLSVENCG------------------------CS [119] 'Oscarella carmela Tgf1' NGVCSRRSYYVDF-QKIGWS---HIVRP-LGYFAYYCGGECPKFFT--SAMN---MTNHA SLQALM--HYLYGGP----K------Y-PPVSCVPV--SYEPLVVAF-PDRN--GH---F K----IR-TYKNMVAKHCG------------------------CH [120] 'Oscarella carmela Tgfb1' LDNCCIREFYIDFKKDLGWT---WIIQP-KGFYANECSGECPMYWA-----E---DTNHT QVINEY--RTLN--PEA---------S-VAPCCTPK--TLNDLEMLH-FPGG--GPPGPP I----TS-TLTDMLVTSCI------------------------CA [121] 'Oscarella carmela Tgfb2' SGCCGLNELYVDFHRDLGFH---WIIQP-SGYWVNECTGECPDFLE-----S---DVEHG RILNLF--YSVN--PTA---------S-ASPCCVAK--SYESIDVLY-VTEK--NE---I K----VK-EMSDMIASACS------------------------CR [122] 'Saccoglossus kowalevskii Activin-like' ISICCRKSFYVSF-EDIHWND--WIIEP-SGFYANHCNGSCEGNTL--P------RYQHT TMMQRVS-RLYSRHNS-QRPS-----D-LTPCCTPT--AMSGITLLY-YNST--GY---I I----KK-NLPNMSVESCG------------------------CS [123] 'Saccoglossus kowalevskii Admp' KTPCSKQKLYVDF-EEIGWSG--WIISP-RGYNAYHCKGECPFPLG--QTSK---PTNHA TVQSIV--NALKL-G-D--E------V-AMPCCVPD--KLFSISLLY-FDED--DN---V V----LK-QYDDMVAASCG------------------------CH [124] 'Saccoglossus kowalevskii Bmp10-like' KNACQRQPMYVHF-KDIGWDE--WIIAP-KGYQAYQCNGKCTFPLT--DHWS---PTKHA IVQTLV--HSAK--P-S--K------V-SRVSCVPT--KLDPISILY-YDDA--GV---V T----YKYKYDGMVVAECG------------------------CR [125] 'Saccoglossus kowalevskii Bmp2/4' KLNCKRHELYVDF-NDVGWND--WIVAP-PGYHAFYCHGECPFPIA--EHLN---STNHA IVQTLV--NSVS--P-D--S------V-PKACCVPT--DLSPISMLY-LDEF--DK---V V----LK-NYQDMVVEGCG------------------------CR [126] 'Saccoglossus kowalevskii Bmp3-like' WKLCGRHVMRVDF-QLIGWNA--YVISP-KSFDAFYCSGECPFPMT--KELN---PSNHA AVQSIV--HALDA-V-K--G------V-PPPCCVPD--KLSPLSILY-FDES--RN---V V----LK-VYPNMVVDTCA------------------------CR [127] 'Saccoglossus kowalevskii Bmp5-8' DRSCKKRSLVVSF-RELGWQD--WIIAP-DGYSAFYCNGECSFPLN--AHMN---ATNHA IVQTLV--HLMD--P-E--A------V-PKPCCAPT--KLNAISVLY-FDDS--SN---V I----LK-KYRNMIVKSCG------------------------CH [128] 'Saccoglossus kowalevskii Gdf8/11-like' EERCCRYPLVVDF-VELTW-D--WIIAP-KTYSAYYCAGECPNVYN-----L---QNAHS YFVERA-------NP-R--G------H-AGRCCTGS--EMSPISMIY-FIDE--KS---I M----FG-VVPDMVTIKCE------------------------CS [129] 'Saccoglossus kowalevskii Lefty' SETCCRRPKYISF-RNMEWTNR-WIIEP-RGYEAYECVGPCHI------------RHSSQ AT--------------------------DLINCGVS--KSSPLPMMY-LIQK--GDITQV E----VS-EIPNMVVEECE------------------------CL [130] 'Saccoglossus kowalevskii NodalA' HP-CERVELIVDF-DKIGWGS--WIIFP-KKFDAYQCVGSCPGPVD--GEHN---PNNHA IIQNMV--HTSN--P-D--R------V-PLPCCVPT--KLSSLSMLY-YER---GN---I V----VK-EHEGMVIQECG------------------------CR [131] 'Saccoglossus kowalevskii Tgfb2' ETNCCLRQLYIDFKKDLGWT---WIHAP-QGYNANYCGGACPYLWS-----Q---NTQHT TILSLY--QSLN--P-D--A------S-AVPCCVPK--TLESLTILY-YESR--KP---- K----IT-QLTNMVLTSCK------------------------CS [132] 'Saccoglossus kowalevskii Univin-like' ADICKRHPLYVNF-REVGWHD--WIIAP-AGYEAFYCHGDCPFPLN--ENLN---GTNHA IIQTLV--NTIE--P-N--A------VKSKACCAPT--KLSSISMLY-FDNN--DN---V V----LR-QYENMVVEACG------------------------CL [133] 'Strongylocentrotus purpuratus Bmp2/4' KANCRRHELYVDF-SDVHWND--WIVAP-AGYQAYYCRGECPFPLA--EHLN---TTNHA IVQTLV--NSVN--P-A--L------V-PKACCVPT--ELSAISMLY-LDEY--EK---V V----LK-NYQDMVVEGCG------------------------CG [134] 'Strongylocentrotus purpuratus Bmp3' TNVCDRHSMNVDF-QAIGWDD--YVIAP-ATFQAFYCAGQCAFPIQ--KELH---PSNHA LIQSIM--HLLG--VQT--G------V-PTPCCVPD--KMEPLVLLY-IEQD--ST---V T----LK-KYSDMVVESCG------------------------CH [135] 'Strongylocentrotus purpuratus Lefty' EHRCCRRRKYVDF-RDLSWTSR-WIIEP-AGFEAFDCYGPCHNLRS---------RHIRD IFRLPFYGGSPSGLPSR---------SGGHRTCGVS--RSSALPMMY-LSATE-SGAVEL K----VE-EIPNMIVEDCS------------------------CL [136] 'Strongylocentrotus purpuratus Nodal' GP-CRRIDMDVDF-GRIGWDE--WIIYP-KQFNAYRCVGTCKGPLD--SRDN---PSNHA VMQDLV--RLHQ--PER--R------T-PEPCCVPT--ILRPLSMLY-FEE---GA---V L----VR-HHENMIVEECG------------------------CR [137] 'Strongylocentrotus purpuratus Univin' TNLCQRHRLFVSF-RDVGWEN--WIIAP-MGYQAYYCDGECPFPLG--ERLN---GTNHA IIQTLV--NSID--N-R--A------V-PKVCCAPT--KLSGISMLY-FDNN--EN---V V----LR-QYEDMVVEACG------------------------CR [138] 'Tribolium castaneum Activin' GNQCCKQRFYVSF-KQLGWDD--WVIAP-QGYHANYCRGDCGLHRT--PDTY---VTYHT HVIEEV--RKTHHLS----G--------MQPCCAPL--KFSSMSLIY-YGPD--MT---I I----KR-DLPKMVVDECG------------------------CP [139] 'Tribolium castaneum Gdf8' EPLCCRYPLTVDF-EEFGW-D--FIIAP-KRYDAHYCSGECPYVTL-----Q---KYPHT HLMKMA-------SP----N------S-AQPCCAPR--KMSAISMLY-FDNQ--LN---V V----YG-SLPGMVVDRCG------------------------CS [140] 'Xenopus laevis InhibinbB' TNLCCRQQFYIDF-RLIGWND--WIIAP-AGYYGNYCEGSCPAYLAGVPGSA---SSFHT AVVNQY--RMRGLNP----G------T-VNSCCIPT--KLSTMSMLY-FDDE--YN---I V----KR-DVPNMIVDECG------------------------CA [141] 'Xenopus laevis InhibinbC' SNLCCRKDYYVDF-KDIGWND--WIIKP-EGYQINYCMGLCPMHIAGAPGMA---ASFHT TVLNLI--KANNIQT-----------A-VNSCCVPT--KRRPLSMLY-FDRN--NN---V L----KT-DIADMIVEACG------------------------CS [142] 'Xenopus laevis Admp' QLPCQRHPLYVDF-EEIGWSG--WIISP-RGYNAYHCKGSCPFPLG--QNMR---PTNHA TVQSII--NALKL-T-K--G------V-SSPCCVPD--KLFSINLLY-FDDD--EN---V V----LK-QYDDMVAGSCG------------------------CH [143] 'Xenopus laevis Bmp2' KSSCRRHPLYVDF-SDVGWND--WIVAP-PGYHAFYCHGECPFPLA--DHLN---STNHA IVQTLV--NSVN----T--N------I-PKACCVPT--ELSAISMLY-LDEN--EK---V V----LK-NYQDMVVEGCG------------------------CR [144] 'Xenopus laevis Bmp3' PRNCARRYLKVDF-ADIGWSE--WIISP-KSFDAYYCSGACQFPMP--KSLK---PSNHA TIQSIV--RAVGV-V-P--G------I-PEPCCVPE--KMSSLSILF-LDEN--KN---V V----LK-VYPNMTVESCA------------------------CR [145] 'Xenopus laevis Bmp4' NKHCRRHSLYVDF-SDVGWND--WIVAP-PGYQAFYCHGDCPFPLA--DHLN---STNHA IVQTLV--NSVN----A--S------I-PKACCVPT--ELSAISMLY-LDEY--DK---V V----LK-NYQEMVVEGCG------------------------CR [146] 'Xenopus laevis Bmp6' KTACRKHELYVSF-QDLGWQD--WIIAP-KGYSANYCGGECSFPLN--AHMN---ATNHA IVQTLV--HLMN--P-E--Y------V-PKPCCAPT--KLNAVSVLY-FDDN--SN---V I----LK-KYRNMVVRACG------------------------CH [147] 'Xenopus laevis Bmp7' KQACKKHELFVSF-RDLGWQD--WIIAP-EGYAAYYCEGECAFPLN--SFMN---ATNHA IVQTLV--HFIN--P-E--T------V-PKPCCAPT--QLNGISVLY-FDDS--AN---V I----LK-KYKNMVVQACG------------------------CH [148] 'Xenopus laevis Vg-1' SNICKKRRLYVEF-KDVGWQN--WVIAP-QGYMANYCYGECPYPLT--EILN---GSNHA ILQTLV--HSIE--P-E--D------I-PLPCCVPT--KMSPISMLF-YDNN--DN---V V----LR-HYENMAVDECG------------------------CR [149] 'Xenopus laevis Derriere' SNICKKRRLYIDF-KDVGWQN--WVIAP-RGYMANYCHGECPYPLT--EMLR---GTNHA VLQTLV--HSVE--P-E--N------T-PLPCCAPT--KLSPISMLY-YDNN--DN---V V----LR-HYEDMVVDECG------------------------CK [150] 'Xenopus laevis Gdf6' RLRCSKKPLHVNF-KELGWDD--WIIAP-LEYEAHHCEGVCDFPLR--SHLE---PTNHA IIQTLM--NSMN--P-G--S------T-PPSCCVPT--KLTPISILY-IDAG--NN---V V----YK-QYEDMVVESCG------------------------CR [151] 'Xenopus laevis Gdf7' KTRCSKKPLLVNF-KELGWDD--WIIAP-LDYEAYHCEGVCDFPLR--SHLE---PTNHA IIQTLM--NSMD--P-E--S------T-PPSCCVPS--KLSPISILY-IDSG--NN---V V----YK-QYEDMVVESCS------------------------CR [152] 'Xenopus laevis Lefty' DNICCREEYFINF-RELTWTQY-WIIEP-AGYNAFRCAGSCKQPKY---------PLSH- HY--------------------------GERMCAVV--ESAPLPVMY-LVKK--GDYTEI E----VA-EFPNMIVEKCG------------------------CT [153] 'Xenopus laevis Ndr1' KPLCRRVDMIVDF-EDIGWSS--WIVYP-KKYNAYRCEGACPIPLN--ETFK---PTNHA YMKSVV--KLYQ--P-E--R------V-ECPLCVPV--KMSPLSMLY-YEG---DE---V V----LR-HHQEMIVEECG------------------------CS [154] 'Xenopus laevis Ndr2A' KTLCRRVDMIVDF-EKIEWGD--RIVYP-KRFNAYRCEGACPIPLN--ETFK---PTNHA YIKSLV--KLYD--Q-E--K------V-ECSSCVPV--KMSPLSMLL-YED---GE---V V----LK-HHEDMIVDECG------------------------CN [155] 'Xenopus laevis Tgfb1' GPNCCVKPLYINFRKDLGWK---WIHEP-KGYEANYCLGNCPYIWS-----M---DTQYS KVLSLY--NQNN--P-G--A------S-ISPCCVPD--VLEPLPIIY-YVGR--TA---- K----VE-QLSNMVVRSCN------------------------CS [156] 'Xenopus laevis Tgfb2' QDNCCLRPLYIDFKKDLGWK---WIHEP-KGYNANFCAGACPYLWS-----S---DTQHS RVLSLY--NTIN--P-E--A------S-ASPCCVSQ--DLDSLTILY-YIGN--KP---- K----IE-QLSNMIVKSCK------------------------CS [157] 'Xenopus tropicalis Bmp10-like' GNYCKKTPLYIDF-GEIGWNS--WIIAP-QGYEAYECRGVCSYPLT--EHVT---PTKHA IVQTLV--HMKN--A-Q--K------A-SKACCVAT--KLDPISILY-LDA---GV---V T----YKFKYEGMVVAECG------------------------CR [158] 'Xenopus tropicalis Bmp5-like' KQACKKHELYVSF-RDLGWED--WIIAP-EGYAAFYCDGECSFPLN--AHMN---ATNHA IVQTLV--HLMF--P-D--H------V-PKPCCAPT--KLNAISVLY-FDDS--SN---V I----LK-KYRNMVVRSCG------------------------CH [159] 'Xenopus tropicalis Gdf11-like' ESRCCRYPLTVDF-EAFGW-D--WIIAP-KRYKANYCSGQCEYMFM-----Q---KYPHT HLVQQA-------NP-R--G------S-AGPCCTPT--KMSPINMLY-FNDK--QQ---I I----YG-KIPGMVVDRCG------------------------CS [160] 'Xenopus tropicalis Gdf5' KARCSKKPLHVNF-KDMGWDD--WIIAP-LEYEAYHCEGLCEFPLR--SHLE---PTNHA VIQTLM--NSMD--P-E--T------T-PPTCCVPT--RLSPISILY-TDSA--NN---V V----YK-QYEDMVVESCG------------------------CR [161] 'Xenopus tropicalis Gdf6' RLRCSKKPLHVNF-KELGWDD--WIIAP-LEYEAYHCEGVCDFPLR--SHLE---PTNHA IIQTLM--NSMD--P-G--S------T-PPSCCVPT--KLTPISILY-IDAG--NN---V V----YK-QYEDMVVESCG------------------------CR [162] 'Xenopus tropicalis Gdf8-like' ESRCCRYPLTVDF-EAFGW-D--WIIAP-KRYKANYCSGECGIVFL-----Q---KYPHT HLVQQA-------NP-R--G------S-AGPCCTPT--KMSPINMLY-FNEN--EQ---I I----YG-KIPAMVVDRCG------------------------CS ; END; BEGIN TREES; Title 'Trees from "E2-TGF-162.nexus"'; TREE 'PhyML ML tree' = [PhyML LG+G4, 100 bootstrap replicates](((((((((((((((('Branchiostoma floridae Bmp2/4':0.03683,(('Danio rerio Bmp2a':0.05994,(('Xenopus laevis Bmp2':0.00732,'Mus musculus Bmp2':0.01671)83:0.03728,(('Xenopus laevis Bmp4':0.01585,'Mus musculus Bmp4':0.00000)99:0.01798,'Danio rerio Bmp4':0.04799)69:0.03402)13:0.01932)17:0.00920,('Saccoglossus kowalevskii Bmp2/4':0.07940,('Nematostella vectensis Bmp2/4':0.16776,('Acropora millepora Bmp2/4':0.00776,'Acropora digitifera Bmp2/4':0.00000)100:0.13061)90:0.10537)19:0.00986)18:0.02622)7:0.01661,'Strongylocentrotus purpuratus Bmp2/4':0.09090)25:0.01691,'Drosophila melanogaster Dpp':0.27059)26:0.03284,'Lottia gigantea Bmp2/4':0.13744)72:0.03564,('Hydra magnipapillata Bmp2/4':0.68419,'Cladonema pacificum Bmp2/4':0.24143)96:0.53300)20:0.11427,((((('Xenopus laevis Derriere':0.05068,'Xenopus laevis Vg-1':0.09837)86:0.05519,'Mus musculus Gdf1':0.58547)12:0.02592,'Danio rerio Vgr1':0.05543)34:0.07344,'Mus musculus Gdf3':0.37774)67:0.09847,(('Strongylocentrotus purpuratus Univin':0.15819,'Saccoglossus kowalevskii Univin-like':0.13566)35:0.00097,'Branchiostoma floridae Univin':0.18926)34:0.04816)57:0.09810)15:0.08080,((((((((('Xenopus tropicalis Gdf6':0.00000,'Xenopus laevis Gdf6':0.01631)58:0.00816,'Mus musculus Gdf6':0.00000)96:0.03949,(('Xenopus tropicalis Gdf5':0.02907,'Mus musculus Gdf5':0.02049)73:0.03742,'Danio rerio Gdf5':0.05460)90:0.04612)20:0.00953,('Xenopus laevis Gdf7':0.02800,'Danio rerio Gdf7':0.01311)61:0.01361)20:0.00802,'Mus musculus Gdf7':0.11521)27:0.01588,'Danio rerio Gdf6A':0.01829)96:0.16311,'Branchiostoma floridae Gdf5-7':0.22210)71:0.07918,('Nematostella vectensis Gdf5-like':0.16859,('Acropora millepora Gdf5-like':0.00000,'Acropora digitifera Gdf5-like':0.00000)100:0.22517)99:0.23647)55:0.08711,((('Xenopus tropicalis Bmp10-like':0.05166,'Mus musculus Bmp10':0.08104)97:0.08295,'Danio rerio Bmp10':0.19205)99:0.15241,'Saccoglossus kowalevskii Bmp10-like':0.14291)99:0.22820)41:0.06249)1:0.03789,((('Branchiostoma floridae Bmp5-8':0.07396,(('Saccoglossus kowalevskii Bmp5-8':0.04971,'Lottia gigantea Bmp5-8':0.11428)43:0.04795,(((('Xenopus tropicalis Bmp5-like':0.00774,'Mus musculus Bmp5':0.00000)84:0.00000,'Danio rerio Bmp5':0.01551)86:0.02059,(('Xenopus laevis Bmp6':0.03130,'Mus musculus Bmp6':0.00000)82:0.03081,'Danio rerio Bmp6':0.05494)85:0.02536)25:0.00000,('Xenopus laevis Bmp7':0.04786,('Mus musculus Bmp7':0.01547,'Danio rerio Bmp7':0.01605)64:0.00000)95:0.07826)73:0.03740)13:0.03454)29:0.04264,'Nematostella vectensis Bmp5-8':0.16566)55:0.05819,((('Hydra magnipapillata Bmp5-8c':0.00001,'Hydra magnipapillata Bmp5-8b':0.20055)73:0.07711,'Hydra magnipapillata Bmp5-8a':0.29902)67:0.13178,'Cladonema pacificum Bmp5-8':0.23702)91:0.21871)86:0.18618)5:0.06172,((((('Mus musculus Bmp3':0.00679,('Xenopus laevis Bmp3':0.01558,'Danio rerio Bmp3':0.01556)48:0.00889)98:0.15053,'Branchiostoma floridae Bmp3':0.09119)93:0.18188,'Saccoglossus kowalevskii Bmp3-like':0.15637)43:0.10562,'Strongylocentrotus purpuratus Bmp3':0.43139)84:0.21496,(('Xenopus laevis Admp':0.04892,('Saccoglossus kowalevskii Admp':0.09718,('Lottia gigantea Admp':0.11908,'Branchiostoma floridae Admp':0.14116)65:0.06474)85:0.11028)62:0.04793,'Danio rerio Admp':0.05532)99:0.32301)34:0.08925)0:0.10808,('Branchiostoma floridae Tgf1':0.45974,(('Acropora millepora Tgf1':0.44664,('Acropora millepora Tgf2':0.00262,'Acropora digitifera Tgf2':0.00509)99:0.23956)79:0.22059,('Acropora millepora Tgf3':0.00000,'Acropora digitifera Tgf3':0.00000)100:0.39373)90:0.19535)34:0.15275)0:0.08340,((('Mnemiopsis leidyi Nodal-related':1.15154,(('Acropora millepora Nodal-related B':0.66968,('Acropora millepora Nodal-related A':0.00760,'Acropora digitifera Nodal-related A':0.00000)100:1.34960)24:0.39677,((('Strongylocentrotus purpuratus Nodal':0.35397,(('Lymnaea stagnalis Nodal':0.09654,'Biomphalaria glabrata Nodal':0.06658)57:0.04364,'Lottia gigantea Nodal':0.14789)100:0.41556)26:0.01930,((((('Xenopus laevis Ndr2A':0.15710,'Xenopus laevis Ndr1':0.09048)98:0.09639,'Gallus gallus Nodal':0.18122)72:0.05592,'Danio rerio Nodal-related':0.17899)45:0.07224,'Mus musculus Nodal':0.34592)51:0.06373,'Branchiostoma floridae Nodal':0.27697)65:0.10817)53:0.15070,'Saccoglossus kowalevskii NodalA':0.31389)94:0.22094)1:0.05073)1:0.06746,'Branchiostoma floridae Nodal-related':0.82182)0:0.06709,('Hydra magnipapillata Nodal-related':0.58651,'Cladonema pacificum Nodal-related':0.35668)83:0.46833)0:0.04514)0:0.04942,('Oscarella carmela Tgf1':0.76283,'Oscarella carmela Tgf2':1.01681)24:0.20345)1:0.05921,(('Acropora millepora Tgf4':0.02140,'Acropora digitifera Tgf4':0.07805)99:0.72128,((('Lottia gigantea Tgf1':1.03942,'Lottia gigantea Tgf2':0.89066)42:0.33306,(('Hydra magnipapillata Activin-like 4':0.27605,'Hydra magnipapillata Activin-like 3':0.09559)62:0.20240,'Hydra magnipapillata Activin-like 2':0.09896)99:0.86810)12:0.32288,(('Oscarella carmela Activin-like':0.96933,'Hydra magnipapillata Activin-like 1':0.60122)21:0.14804,((((('Drosophila melanogaster Myoglianin':0.57435,'Lottia gigantea Myostatin':0.47517)35:0.07534,(('Nematostella vectensis Gdf8':0.51196,'Saccoglossus kowalevskii Gdf8/11-like':0.48284)27:0.04405,((((('Xenopus tropicalis Gdf8-like':0.04090,'Mus musculus Gdf8':0.01036)46:0.02152,'Danio rerio Gdf8':0.08059)41:0.03153,(('Xenopus tropicalis Gdf11-like':0.00000,'Mus musculus Gdf11':0.00000)92:0.00000,'Danio rerio Gdf11':0.01823)100:0.01574)88:0.10500,'Tribolium castaneum Gdf8':0.27143)42:0.04967,'Branchiostoma floridae Myostatin':0.20496)30:0.05605)43:0.06830)75:0.22960,'Mnemiopsis leidyi Myostatin':0.79394)22:0.08218,(((('Saccoglossus kowalevskii Activin-like':0.48036,'Branchiostoma floridae Activin':0.14500)65:0.14345,(('Acropora millepora Activin 1':0.02464,'Acropora digitifera Activin 1':0.00968)100:0.79678,('Acropora millepora Activin 2':0.00000,'Acropora digitifera Activin 2':0.00000)100:0.46175)52:0.20038)24:0.09245,'Nematostella vectensis Activin':0.42492)29:0.11188,('Tribolium castaneum Activin':0.53571,(('Xenopus laevis InhibinbB':0.00193,'Mus musculus InhibinbB':0.04540)100:0.24167,('Xenopus laevis InhibinbC':0.46426,('Mus musculus InhibinbA':0.03699,'Danio rerio InhibinbA':0.18218)99:0.14610)21:0.02773)70:0.21376)35:0.09666)23:0.20072)2:0.21026,(((('Oscarella carmela Tgfb2':0.74205,'Oscarella carmela Tgfb1':0.50056)45:0.14460,((('Danio rerio Tgfb2':0.05766,('Mus musculus Tgfb2':0.01722,'Xenopus laevis Tgfb2':0.03434)67:0.01411)71:0.04819,(('Xenopus laevis Tgfb1':0.17032,'Mus musculus Tgfb1':0.03781)99:0.12794,('Mus musculus Tgfb3':0.03990,'Danio rerio Tgfb3':0.03203)99:0.04405)84:0.05903)89:0.10763,'Saccoglossus kowalevskii Tgfb2':0.21872)53:0.10724)61:0.37438,(((('Xenopus laevis Lefty':0.05997,'Danio rerio Lefty1':0.15379)66:0.28791,'Branchiostoma floridae Lefty':0.49600)69:0.26793,('Strongylocentrotus purpuratus Lefty':0.48012,'Saccoglossus kowalevskii Lefty':0.37665)53:0.19402)33:0.23493,'Mus musculus Lefty1':1.05384)96:0.58335)1:0.10650,(('Cladonema pacificum Gdf8/Tgfb-like':1.22431,'Branchiostoma floridae Gdf8/Tgfb-like':0.78097)23:0.17048,'Mnemiopsis leidyi TgfbA':0.96451)17:0.21410)0:0.07273)0:0.05325)0:0.01656)0:0.13650)2:0.14677)2:0.09975,('Acropora millepora Tgf5':2.48548,('Lottia gigantea Tgf3':1.51831,'Mnemiopsis leidyi Tgf4':1.22515)4:0.28056)1:0.06618)0:0.12217,((('Mnemiopsis leidyi Tgf1a':0.47447,'Mnemiopsis leidyi Tgf1b':1.10415)87:0.58674,'Oscarella carmela Tgf3':1.30806)19:0.21013,'Hydra magnipapillata Tgf1':1.93002)0:0.02128):0.24296,('Mnemiopsis leidyi Tgf3':1.43817,('Mnemiopsis leidyi Tgf2':0.82340,('Hydra magnipapillata Tgf2':0.29169,('Hydra magnipapillata Tgf3':0.20974,'Hydra magnipapillata Tgf4':0.13181)50:0.14456)100:1.25414)29:0.12641):0.17490)24; TREE 'IQPNNI ML consensus tree' = [IQPNNI WAG+G4, 200 bootstrap replicates, relative majority consensus]('Acropora digitifera Bmp2/4':0.00001,((('Mus musculus Bmp2':0.01587,'Xenopus laevis Bmp2':0.00759)79:0.05494,(('Mus musculus Bmp4':0.00001,'Xenopus laevis Bmp4':0.01552)91:0.01603,'Danio rerio Bmp4':0.04829)53:0.03584,((('Hydra magnipapillata Tgf4':0.11832,'Hydra magnipapillata Tgf3':0.18029)69:0.22128,'Hydra magnipapillata Tgf2':0.17222)100:1.50196,('Acropora digitifera Nodal-related A':0.00768,'Acropora millepora Nodal-related A':0.00001)100:1.57035,('Acropora digitifera Tgf4':0.06893,'Acropora millepora Tgf4':0.03045)98:0.84536,(('Hydra magnipapillata Activin-like 3':0.09796,'Hydra magnipapillata Activin-like 4':0.26646)62:0.19884,'Hydra magnipapillata Activin-like 2':0.08789)98:1.40259,(('Acropora digitifera Gdf5-like':0.00001,'Acropora millepora Gdf5-like':0.00001)100:0.21917,'Nematostella vectensis Gdf5-like':0.14366)96:0.36995,(((('Danio rerio Lefty1':0.13522,'Xenopus laevis Lefty':0.06863)74:0.25187,'Branchiostoma floridae Lefty':0.44039)69:0.26392,('Saccoglossus kowalevskii Lefty':0.34243,'Strongylocentrotus purpuratus Lefty':0.43651)61:0.14482)45:0.17148,'Mus musculus Lefty1':0.98517)96:1.07293,('Mnemiopsis leidyi Tgf1b':1.10720,'Mnemiopsis leidyi Tgf1a':0.22654)94:1.35214,(((('Branchiostoma floridae Admp':0.12694,'Lottia gigantea Admp':0.11134)67:0.07092,'Saccoglossus kowalevskii Admp':0.08769)75:0.09906,'Xenopus laevis Admp':0.05158)49:0.04804,'Danio rerio Admp':0.04854)93:0.46620,((('Mus musculus Bmp10':0.06989,'Xenopus tropicalis Bmp10-like':0.05685)95:0.08744,'Danio rerio Bmp10':0.16973)94:0.12658,'Saccoglossus kowalevskii Bmp10-like':0.14576)90:0.28315,('Cladonema pacificum Bmp2/4':0.19749,'Hydra magnipapillata Bmp2/4':0.63645)83:0.56521,(('Acropora digitifera Tgf3':0.00001,'Acropora millepora Tgf3':0.00001)100:0.37773,(('Acropora digitifera Tgf2':0.00774,'Acropora millepora Tgf2':0.00001)99:0.16803,'Acropora millepora Tgf1':0.45039)78:0.19248)82:0.38290,(('Mus musculus InhibinbB':0.03171,'Xenopus laevis InhibinbB':0.01535)99:0.23593,('Danio rerio InhibinbA':0.16983,'Mus musculus InhibinbA':0.04382)94:0.15986,'Xenopus laevis InhibinbC':0.39531)70:0.78196,(((('Mus musculus Gdf11':0.00001,'Xenopus tropicalis Gdf11-like':0.00001)90:0.00001,'Danio rerio Gdf11':0.01769)100:0.03167,('Danio rerio Gdf8':0.08936,'Mus musculus Gdf8':0.01689,'Xenopus tropicalis Gdf8-like':0.03824)44:0.02607)84:0.11049,'Branchiostoma floridae Myostatin':0.20382,'Drosophila melanogaster Myoglianin':0.65625,'Lottia gigantea Myostatin':0.60053,'Nematostella vectensis Gdf8':0.52443,'Saccoglossus kowalevskii Gdf8/11-like':0.48908,'Tribolium castaneum Gdf8':0.27714)65:0.74767,((('Biomphalaria glabrata Nodal':0.06592,'Lymnaea stagnalis Nodal':0.08319)59:0.03892,'Lottia gigantea Nodal':0.13329)92:0.39141,((((('Xenopus laevis Ndr1':0.08486,'Xenopus laevis Ndr2A':0.14202)95:0.08418,'Gallus gallus Nodal':0.17128)63:0.05558,'Danio rerio Nodal-related':0.16766)44:0.06541,'Mus musculus Nodal':0.31258)53:0.04968,'Branchiostoma floridae Nodal':0.26307)51:0.11648,'Saccoglossus kowalevskii NodalA':0.40196,'Strongylocentrotus purpuratus Nodal':0.32941)63:0.55289,(((('Hydra magnipapillata Bmp5-8b':0.19025,'Hydra magnipapillata Bmp5-8c':0.00001)63:0.07519,'Hydra magnipapillata Bmp5-8a':0.27403)51:0.13731,'Cladonema pacificum Bmp5-8':0.20253)76:0.24584,(('Danio rerio Bmp7':0.01545,'Mus musculus Bmp7':0.01507,'Xenopus laevis Bmp7':0.04620)100:0.07915,(('Mus musculus Bmp5':0.00001,'Xenopus tropicalis Bmp5-like':0.00758)83:0.00001,'Danio rerio Bmp5':0.01519)82:0.01712,(('Mus musculus Bmp6':0.00001,'Xenopus laevis Bmp6':0.03064)82:0.02929,'Danio rerio Bmp6':0.05280)68:0.02610)65:0.06030,'Branchiostoma floridae Bmp5-8':0.10083,'Lottia gigantea Bmp5-8':0.13456,'Nematostella vectensis Bmp5-8':0.21743,'Saccoglossus kowalevskii Bmp5-8':0.07530)61:0.32365,(((('Danio rerio Bmp3':0.01544,'Xenopus laevis Bmp3':0.01555)46:0.01542,'Mus musculus Bmp3':0.00001)97:0.13808,'Branchiostoma floridae Bmp3':0.10895)79:0.17287,'Saccoglossus kowalevskii Bmp3-like':0.14299,'Strongylocentrotus purpuratus Bmp3':0.45256)55:0.45978,('Lottia gigantea Tgf2':0.70327,'Lottia gigantea Tgf1':1.14745)54:0.89622,('Cladonema pacificum Nodal-related':0.28208,'Hydra magnipapillata Nodal-related':0.55206)54:0.54078,('Saccoglossus kowalevskii Univin-like':0.14090,'Strongylocentrotus purpuratus Univin':0.13420)50:0.21250,((((('Xenopus laevis Gdf6':0.01598,'Xenopus tropicalis Gdf6':0.00001)56:0.00800,'Mus musculus Gdf6':0.00001)93:0.04746,(('Mus musculus Gdf5':0.01785,'Xenopus tropicalis Gdf5':0.02983)85:0.03529,'Danio rerio Gdf5':0.05197)92:0.05488,('Danio rerio Gdf7':0.01382,'Xenopus laevis Gdf7':0.02595)46:0.01541,'Danio rerio Gdf6A':0.03517)51:0.02123,'Mus musculus Gdf7':0.09686)92:0.14964,'Branchiostoma floridae Gdf5-7':0.22489)49:0.19200,(('Xenopus laevis Vg-1':0.09567,'Xenopus laevis Derriere':0.04740)68:0.07151,'Danio rerio Vgr1':0.06711,'Mus musculus Gdf1':0.54320,'Mus musculus Gdf3':0.39589)47:0.28331,(('Acropora digitifera Activin 1':0.00521,'Acropora millepora Activin 1':0.02857)100:0.61155,('Acropora digitifera Activin 2':0.00001,'Acropora millepora Activin 2':0.00001)100:0.52358)46:0.79831,(((('Mus musculus Tgfb1':0.03587,'Xenopus laevis Tgfb1':0.16355)98:0.12435,('Danio rerio Tgfb3':0.03267,'Mus musculus Tgfb3':0.03757)97:0.03692)85:0.05663,(('Mus musculus Tgfb2':0.01735,'Xenopus laevis Tgfb2':0.03339)59:0.01742,'Danio rerio Tgfb2':0.05232)62:0.05078)80:0.14578,'Saccoglossus kowalevskii Tgfb2':0.14768)46:0.85760,'Acropora millepora Tgf5':2.60444,'Acropora millepora Nodal-related B':1.20414,'Branchiostoma floridae Activin':1.00990,'Branchiostoma floridae Tgf1':0.69080,'Branchiostoma floridae Nodal-related':1.02137,'Branchiostoma floridae Gdf8/Tgfb-like':1.32518,'Branchiostoma floridae Univin':0.29390,'Cladonema pacificum Gdf8/Tgfb-like':1.94594,'Hydra magnipapillata Activin-like 1':1.19499,'Hydra magnipapillata Tgf1':1.84210,'Lottia gigantea Tgf3':2.22446,'Mnemiopsis leidyi Tgf4':1.55681,'Mnemiopsis leidyi Myostatin':1.07152,'Mnemiopsis leidyi TgfbA':1.80028,'Mnemiopsis leidyi Tgf2':1.58345,'Mnemiopsis leidyi Nodal-related':1.25614,'Mnemiopsis leidyi Tgf3':1.98416,'Nematostella vectensis Activin':1.23563,'Oscarella carmela Tgf3':2.11041,'Oscarella carmela Tgf2':1.29895,'Oscarella carmela Activin-like':1.27474,'Oscarella carmela Tgf1':1.14851,'Oscarella carmela Tgfb1':1.31429,'Oscarella carmela Tgfb2':1.30823,'Saccoglossus kowalevskii Activin-like':1.30736,'Tribolium castaneum Activin':1.19881)53:0.31768,'Branchiostoma floridae Bmp2/4':0.07048,'Drosophila melanogaster Dpp':0.26681,'Danio rerio Bmp2a':0.08865,'Lottia gigantea Bmp2/4':0.18609,'Saccoglossus kowalevskii Bmp2/4':0.10678,'Strongylocentrotus purpuratus Bmp2/4':0.09906)81:0.10480,'Nematostella vectensis Bmp2/4':0.17850)100:0.10767,'Acropora millepora Bmp2/4':0.00767); TREE 'BioNJ consensus tree' = [BioNJ WAG+G4, 200 bootstrap replicates, relative majority consensus]('Acropora digitifera Bmp2/4':0.00001,((('Mus musculus Bmp2':0.01631,'Xenopus laevis Bmp2':0.00758)93:0.05469,(('Mus musculus Bmp4':0.00001,'Xenopus laevis Bmp4':0.01583)99:0.01664,'Danio rerio Bmp4':0.04886)71:0.03679,((('Acropora digitifera Nodal-related A':0.00001,'Acropora millepora Nodal-related A':0.00777)100:1.64334,('Acropora digitifera Tgf4':0.07097,'Acropora millepora Tgf4':0.03018)100:0.91037,(('Acropora digitifera Gdf5-like':0.00001,'Acropora millepora Gdf5-like':0.00001)100:0.22149,'Nematostella vectensis Gdf5-like':0.14806)100:0.35367,(('Hydra magnipapillata Tgf4':0.12045,'Hydra magnipapillata Tgf3':0.18395)90:0.22452,'Hydra magnipapillata Tgf2':0.17565)100:1.53357,(('Hydra magnipapillata Activin-like 3':0.09863,'Hydra magnipapillata Activin-like 4':0.26970)71:0.20033,'Hydra magnipapillata Activin-like 2':0.08796)99:1.42612,(('Danio rerio Admp':0.09624,'Xenopus laevis Admp':0.05346)64:0.05549,(('Branchiostoma floridae Admp':0.12559,'Lottia gigantea Admp':0.11702)80:0.07325,'Saccoglossus kowalevskii Admp':0.08696)55:0.04833)97:0.48047,((('Mus musculus Bmp10':0.07027,'Xenopus tropicalis Bmp10-like':0.05861)98:0.08758,'Danio rerio Bmp10':0.17316)95:0.12717,'Saccoglossus kowalevskii Bmp10-like':0.15007)94:0.26540,('Mnemiopsis leidyi Tgf1b':1.10744,'Mnemiopsis leidyi Tgf1a':0.23737)89:1.37466,(('Saccoglossus kowalevskii Lefty':0.34318,'Strongylocentrotus purpuratus Lefty':0.43398)64:0.18762,(('Danio rerio Lefty1':0.13534,'Xenopus laevis Lefty':0.06959)46:0.24105,'Branchiostoma floridae Lefty':0.45478)62:0.25899,'Mus musculus Lefty1':1.11883)86:1.23466,(('Acropora digitifera Tgf3':0.00001,'Acropora millepora Tgf3':0.00001)100:0.35469,(('Acropora digitifera Tgf2':0.00786,'Acropora millepora Tgf2':0.00001)100:0.18118,'Acropora millepora Tgf1':0.45029)88:0.21556)83:0.37018,('Cladonema pacificum Bmp2/4':0.22738,'Hydra magnipapillata Bmp2/4':0.60645)81:0.54274,(((('Danio rerio Bmp3':0.01648,'Mus musculus Bmp3':0.01573,'Xenopus laevis Bmp3':0.01562)100:0.14989,'Branchiostoma floridae Bmp3':0.10479)86:0.17903,'Saccoglossus kowalevskii Bmp3-like':0.13192)74:0.10917,'Strongylocentrotus purpuratus Bmp3':0.38095)71:0.38322,('Cladonema pacificum Nodal-related':0.28258,'Hydra magnipapillata Nodal-related':0.56783)69:0.54223,(((((('Danio rerio Bmp7':0.01569,'Mus musculus Bmp7':0.01530)61:0.00001,'Xenopus laevis Bmp7':0.04689)96:0.08038,((('Mus musculus Bmp5':0.00001,'Xenopus tropicalis Bmp5-like':0.00769)64:0.00001,'Danio rerio Bmp5':0.01542)96:0.01717,(('Mus musculus Bmp6':0.00001,'Xenopus laevis Bmp6':0.03111)84:0.02974,'Danio rerio Bmp6':0.05364)61:0.02657)51:0.00001)63:0.05994,'Branchiostoma floridae Bmp5-8':0.10134,'Lottia gigantea Bmp5-8':0.13778,'Saccoglossus kowalevskii Bmp5-8':0.07711)51:0.04032,'Nematostella vectensis Bmp5-8':0.18409)88:0.06917,((('Hydra magnipapillata Bmp5-8b':0.19408,'Hydra magnipapillata Bmp5-8c':0.00001)99:0.07008,'Hydra magnipapillata Bmp5-8a':0.28498)73:0.14441,'Cladonema pacificum Bmp5-8':0.20772)82:0.19787)68:0.23259,((('Biomphalaria glabrata Nodal':0.06558,'Lymnaea stagnalis Nodal':0.08587)91:0.04058,'Lottia gigantea Nodal':0.13380)99:0.39890,(((('Xenopus laevis Ndr1':0.08696,'Xenopus laevis Ndr2A':0.14366)75:0.08645,'Gallus gallus Nodal':0.17378)46:0.06212,'Danio rerio Nodal-related':0.16433)69:0.08123,'Branchiostoma floridae Nodal':0.29164,'Mus musculus Nodal':0.32736)68:0.15258,'Saccoglossus kowalevskii NodalA':0.40484,'Strongylocentrotus purpuratus Nodal':0.33488)68:0.55854,((((('Mus musculus Gdf5':0.01898,'Xenopus tropicalis Gdf5':0.02953)96:0.03663,'Danio rerio Gdf5':0.05359)83:0.03857,(((('Mus musculus Gdf6':0.00812,'Xenopus tropicalis Gdf6':0.00001)52:0.00001,'Xenopus laevis Gdf6':0.01623)91:0.04977,('Danio rerio Gdf7':0.02358,'Xenopus laevis Gdf7':0.01689)75:0.01549)60:0.00001,'Danio rerio Gdf6A':0.02604)77:0.02166)58:0.02224,'Mus musculus Gdf7':0.08404)100:0.16844,'Branchiostoma floridae Gdf5-7':0.21883)63:0.18806,((((('Mus musculus Gdf11':0.00001,'Xenopus tropicalis Gdf11-like':0.00001)64:0.00001,'Danio rerio Gdf11':0.01788)98:0.03610,('Mus musculus Gdf8':0.01859,'Xenopus tropicalis Gdf8-like':0.03521)80:0.02418)78:0.00789,'Danio rerio Gdf8':0.08153)86:0.12554,'Branchiostoma floridae Myostatin':0.20145,'Drosophila melanogaster Myoglianin':0.67038,'Lottia gigantea Myostatin':0.60721,'Nematostella vectensis Gdf8':0.53215,'Saccoglossus kowalevskii Gdf8/11-like':0.49818,'Tribolium castaneum Gdf8':0.28547)56:0.78232,(('Acropora digitifera Activin 2':0.00001,'Acropora millepora Activin 2':0.00001)100:0.50734,('Acropora digitifera Activin 1':0.00498,'Acropora millepora Activin 1':0.02923)100:0.64063)51:0.80101,((((('Danio rerio Tgfb2':0.06854,'Mus musculus Tgfb2':0.01804)57:0.00001,'Xenopus laevis Tgfb2':0.03491)73:0.05738,(('Mus musculus Tgfb1':0.03619,'Xenopus laevis Tgfb1':0.16743)93:0.12308,('Danio rerio Tgfb3':0.03277,'Mus musculus Tgfb3':0.03894)67:0.04158)61:0.05865)93:0.18278,'Saccoglossus kowalevskii Tgfb2':0.11537)44:0.12052,'Oscarella carmela Tgfb1':0.50950)44:0.79645,(('Branchiostoma floridae Activin':0.16967,'Saccoglossus kowalevskii Activin-like':0.41274)61:0.10595,'Nematostella vectensis Activin':0.37323)44:0.88966,((('Mus musculus InhibinbB':0.03079,'Xenopus laevis InhibinbB':0.01699)100:0.23400,('Danio rerio InhibinbA':0.17223,'Mus musculus InhibinbA':0.04453)94:0.15351)85:0.13492,'Xenopus laevis InhibinbC':0.28392)43:0.73359,(('Saccoglossus kowalevskii Univin-like':0.13611,'Strongylocentrotus purpuratus Univin':0.13912)63:0.07823,(((('Xenopus laevis Vg-1':0.09318,'Xenopus laevis Derriere':0.05138)91:0.06263,'Danio rerio Vgr1':0.06788)67:0.00931,'Mus musculus Gdf1':0.55521)44:0.04206,'Mus musculus Gdf3':0.36097)50:0.11551,'Branchiostoma floridae Univin':0.15997)43:0.21140,'Acropora millepora Tgf5':2.59993,'Acropora millepora Nodal-related B':1.19196,'Branchiostoma floridae Tgf1':0.69683,'Branchiostoma floridae Nodal-related':1.03155,'Branchiostoma floridae Gdf8/Tgfb-like':1.30387,'Cladonema pacificum Gdf8/Tgfb-like':1.88750,'Hydra magnipapillata Activin-like 1':1.13621,'Hydra magnipapillata Tgf1':1.83433,'Lottia gigantea Tgf2':1.54106,'Lottia gigantea Tgf1':2.10391,'Lottia gigantea Tgf3':2.16149,'Mnemiopsis leidyi Tgf4':1.56930,'Mnemiopsis leidyi Myostatin':1.06077,'Mnemiopsis leidyi TgfbA':1.73222,'Mnemiopsis leidyi Tgf2':1.60974,'Mnemiopsis leidyi Nodal-related':1.26137,'Mnemiopsis leidyi Tgf3':2.06331,'Oscarella carmela Tgf3':2.07327,'Oscarella carmela Tgf2':1.23491,'Oscarella carmela Activin-like':1.26605,'Oscarella carmela Tgf1':1.13776,'Oscarella carmela Tgfb2':1.30208,'Tribolium castaneum Activin':1.21549)62:0.26155,'Drosophila melanogaster Dpp':0.18974)54:0.08853,'Branchiostoma floridae Bmp2/4':0.07223,'Danio rerio Bmp2a':0.08795,'Lottia gigantea Bmp2/4':0.19165,'Saccoglossus kowalevskii Bmp2/4':0.10914,'Strongylocentrotus purpuratus Bmp2/4':0.10108)86:0.10521,'Nematostella vectensis Bmp2/4':0.18168)100:0.11021,'Acropora millepora Bmp2/4':0.00782); END;