#NEXUS BEGIN DATA; Dimensions NTax=46 NChar=1202; Format DataType=Protein Gap=-; Matrix root --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCGCK-----------EKLLK-LG--------------------------------------------VVGGIG----DDAAVI---------------------------------KIGDGLSLVS-----------------------------TTD-----FFFP--V-DPYDQGRIAVANAVNDLAAMG--AKPLAL-LDVLALPE---------------------EVLEEILKGIREGAKEAGVPLV-GGHTVV------GPWPILGGTVVGVVDREK----PITYSGAKPGDVIILTG----PLGIHGAGLALLAL-E-E-------------FETVEEADPEATKIMVRPNL-EAAK---------------D-GVNAMTDITGGGLLGHLKELAEASG-VGIEI--DKLPVIEEV-SEFA----------------N-------------PLEGALAGT-GGLLIFVAPEA-DEVLDILKK---------GL-AAVIGEVTGKGGG-----VP----------------I------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_like_Acidianus_hospitalis ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEEVFERFRKNLEVY-NKMGLNPLSLATGCAVKVDLIDTVYPALEKIKNKLE--NIEILPREDADIFITREKMEIKRIIGG-----------------GNFD----ADRGVSLIQVNQDTAGNPEKFANFLLKTYSSIRS-RRKLTIGKGHSIVTTIPSAEVAVLDLIKLDGSKINSYTLANNDTIQ-----IVDPLEDPGSQMQVDVAISNSLNDLFTKG--AYQNLKMLPLFDAPND--------------------DLKERIMKNYENYSEKYDIPII-NDIQPN------TKSLMLGATVLGESDHEL----PTYYDKVEEGDEIIVTR----PIGELAPINVYLWILVVPEVLELMES-RGISFKRLEKVKMEVIEQMRKPNI-PTAKVIYNYLPEFGKSFDRENYITMTTDVTGPGIFVI-KEFAEKAG-VDVRL--DKIPVIDEEIAEFATE--------------GF------------IIPNSTSGTNGATVVFYSRRISDDIIEDLQK--------EGLKPIKIGKVLGKGQGVVH--VNK----------DIERFIHRKNVLSHFKID------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_like_Metallosphaera_cuprina --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAMSDLFERFRDNLNKY-KKMGINPLSLATGCAVKVDLIDTVYPALEKLKEKLLANNIEVMPREDTDIFVSRESEVLKRVING-----------------GEFD----ADRAISLIQVNQETAGNPEKFANFLLKIYTGVKT-RRKLIVGKGHSIVTTNPKAEVGILDLFKLDGRELRSYTLSNNDTIQ-----IVDPLDDPGSQMQVDVGVSNSLNDLFTKG--AFQDLKMIPVADAPDP--------------------DLKKTLLNNFERFSKRYNVELL-TDVQPS------TGTLMIGATVVGKSDHEL----PTYYDKVDEGMEILVTR----PVGELTPINVHMWLLTVPELIDTMEE-RGITLNKVEEAKKRALDYMTKPNF-DSAEVIYNHLPEFGGKFDLESHVAMTTDVTGPGIFVV-KEFAEKAL-VDVDL--YDVPVIDREISEFATE--------------NF------------IIPNSTAGTNGAIVIFASKKVIDDIAQDLTK--------RGLEPRIIGRVLRKGTGVVY--VKK----------DVCKLIHRENILKHFKVRDAN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_like_Sulfolobus_tokodaii -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHSNMDIFTKFKENLEVY-KSMGLNPLSLATGCAVKVDLIDTVYPALEKIKKILEERNITILPREDADIFVSREKMEMKRLING-----------------GEFD----ADRAITLIQVNQETAGNPDAFSEFLVRVYTSIKT-SRKLTIGKGHSIVTTKKDGEVAVLDLFRLEGREEKSYTVANNDTIQ-----IVDPLDNPGSQVQVDVAISNSLNDLFTKG--VFQELTVVPVVDAPNS--------------------ELKKKLLSNYENYVKKYNMNLR-NDIQPS------VGTLMMGATVVGKSDHEL----PTFYDKVNENMVIITTR----FFGELTPINVHLWSLAVPELIEMMES-RGISFSRIEKVKSEALEIMRRPNI-HVAKVIYSYLPEFGKSFDEKSHIAMTTDVTGPGIFVI-KEFAEKAK-VDVEL--NDIPVIDRDICEFATE--------------NF------------IIPNSTIGTNGAIVMFADKRIADDIMEDLIK--------VGEKPEIVGYVKGKGNGTVY--APK----------DVMKLIRRDNVLKQFKIKE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ SelD_like_Caldivirga_maquilingensis ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKVSKEERMSRFLKHVSKY-ASIGVNLTSLALGCSVKVDLYNVLYPALSIVKRELGELHIKIAPREDVAVLRGSEL-DLMRVITS------VDSPKLPINTISDFN----PDALILLVESFQGNASDPDSFANIMIRLFKELAKVNKELVIGKGHSIVSTQPNASIHVLDFIKVKNKD-DAYTLVNNDTIQ-----VIDPMDEIASRRQVSVALNNALNDLFSKG--AFKDLEFYPVYDAPGE---------------------YKHGLFNEVKAYVNELGGRLH-DVEQPN------LGYLLIGSTVASRLDREP----PMFYNEVKEGFKIIVTR----PFGELSIIGTYVALHVDEELYDKFER-EVMTVDELEEIKEYALNQMAKPNI-DVAKVIYNHLPELGRRFNDDEHVAATIDISGPGIFVF-KELAETAN-VKIRL--SNIPLISPEVAEFAAS--------------NY------------IISDATAGTNGAVALVVSSGLVDDVLDELGKI-------PGLKPMVIGEVVGRGEGTLI--VPD----------YVTRYIKDKVMLTKLTIASNILQGVSRQ------------------------AALRLARAEIMVTGKVQGV-GFRPLVRRNAKSLGLTGFARNNEDGSVLIIVEGEE-----------GNIKAFIESLRNI------NIAEVRELNIKWSS-----------------------------------------YKGEFQDFTIE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_like_Pyrobaculum_aerophilum -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNRLERFKERVKLY-REAGIALESLSLGCSVKVDLYNVLYPALQLLREEMYKLNLVIAPREDAAIMPGASA-ALRRYFLD------VENPRLDPAEVEKLS----PTVAIVLAQVYMGKAAAPDLFAKYVAGLYKALGSSRHKVWLGKGHSIISTKKGAEFFMVDFLKAEGQ--EGYIVANNDTIQ-----VIDPSEDFDSPLQIAVAVNNALNDLFTKG--AWKDIHIAPVYDAPPP---------------------FRGPLEARVKSYASSLGKLV--EAPQPE------MGYLLLGATAYARLDREP----PLFYDKIREGFVVVVTR----PFGELAYFTTYVAVHTDETLMKKFEE-EVMPIEQFEAEKRRVLEIMATPNL-EAAKAIYQYLPDLGERFDPEAHIAATIDVSGPGIFVF-KEVAERAG-VDIRL--FDVPLMSSAVSKFAAD--------------NY------------IMPDATAGTNGAIAIFASRKVAEELVEKLSKA-------PHAKPTVIGVVEGKGEGRLI--VPE----------WALQYISSKKLREKL-GAASVLGGLARV-------------------------VGRPIRAVAYVEGAVQGV-GFRPMARARAKALGLLGYAKNLPDGRVEVVVEGDE-----------ERVRKYVEELCKG-------FENCRVGQVIYAE-----------------------------------------ARGEFSDFSIL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_like_Thermoproteus_uzoniensis -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNPVEKFRERVRLY-REAGIALESLSLGCSVKVDLYDVLYPALELLRDDVRRLNLVIAPREDAAIMRGAGA-ELRRLYLD------PEDPHIDPAFLESYA----PDLAVVLVQLYMAKAATPSKFAEYAARLYKALGSSRHRVWLGKGHSIVSTKKGAEFFMVDFLKAEPG--EGYVLANNDTIQ-----VIDPSEDFDSPLQAAVAVNNALNDLYVKG--VYKDVEIAPVYDAPEP---------------------YRARVKAAVESHAASLGRLV--EAPQPG------RGYLLLGATAYGRLDREP----PTYYSQLGEGFVVLVTR----PFGELAYFTTYVAVNTDEELLKAFEK-SVMPLDQFEKEKRRVLELMAAPNA-DVARVIYDHLPDLGERFDPEAHIAATIDISGPGVFVF-KEVAERAG-VDVEL--WDVPLLGPSVSRFAAE--------------NF------------IMPDATAGTNGAIAVFLHKKLADEVLDELSKI-------PRLRPAVVGRVLGKGEGRLA--VPR----------EALAYISSEKLREKLVGAAQVLGGL----------------------------AGKAVRARAYLEGDVQGI-GFRPTARAKARALGLTGYAANLPDGRVELVVEGDR-----------DRVEKLLQELCAR-------F-NCRVAELAWEP-----------------------------------------AEGAYKDFEIR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_like_Vulcanisaeta_distributa -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEMRDDRIRVFRERLDKY-LDLGINLLSLAIGCSVKVDLYDTLYPALSLVNNEIAKLNIEIQPREDVAVLRSNGDYSLVRRIYD------ITGNGVNKDELVSIN----PSVALLLLQVHQSRASSPREFASSIISLYRRLGSSPVRVRIGKGHSIVSTKEKAEFALIDFISTKSG--DGYLLANNDTIQ-----IIDPTEDPGSYRQVATAVSNALNDLFIKG--VYRDITIYPVYDAPIE--------------------DLKEKLMKNFREFSSKWDLQLSTDVQQPR------VNYLLMGATVVGTLDREP----PMFYDNIKAGFKILITR----PFGELSIISTYLTAHVDESIMDELER-NVMSIEDLEKLKIKIMDILSRPNI-EIARVISKYLPEIGEAFREDEHIAATIDVSGPGIFVF-KELAEQAN-VDVAL--YNIPLISPEVARFAAE--------------HY------------IITDATAGTNGAIAIVASKDVIDSIVRDLRGI-------EDVQPMVIGEVMGKGSGRLF--VPD----------YVTRYITSKSLLMKLTMNIDVLRSLRRQ-----------------------QVKCEKVRVEARVFGNVQGV-GFRPTLRRQALSLGLTGYVRNLPDGSVEVVAEGCK-----------EDVMALIEWIRSS------PVGSVETINYVIKQ-----------------------------------------YFGEFEDFEIR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_Archaea_Methanoplanus_petrolearius ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSDI-EKRKLTSIAPLFGCSCKLPETEL-----ETLLEDIN--IS----YSPEI--------------------------------LC-PG----DDAAVIKIN------------------------------D---DLAIIK-----------------------------TTD-----FFTPI-VDDPYIQGKIAACNATNDVYAMG--ATEIVGVLALLGIPR-----------------ELPLENARMMLKGFQDFCNSIGTSIV-GGHTII------NPWPFIGGAVTAISSPDK----IVYHSGAQPGDVLLLTK----PLGIQPAMASTRLSSEYSSI----IQ-STLDSDIVANAVNLAIECMTTSNL-NAAKAIN------------EVGANALTDVTGFGLYGHGLNIARKSN-VSLNI--DLIPIISGT-LELSALF-------------EHG-----------LEEGKSAETAGGLLMSVSEENLDEIIHSLNKY-------NVP-AYEIGTVKEKGNEHVV--IDN----------PEI--LEISSLSVKFES-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_Archaea_Methanocaldococcus_jannaschii --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERGN-EKIKLTELVKLHGCACKLPSTEL-----EFLVKGIV--TDDDLLDKNIL--------------------------------VG-LG----DDASIIKRN----------------------------------GLVIAK-----------------------------TVD-----VFTPI-VDDPYIQGKIAACNSTSDIYAMG--LLDIVGVLAIVGIPE-----------------KLPIHVVREMLKGFQDFCRENKTTIV-GGHTIL------NPWPLIGGAVTGVGREEE----VLTKAGVKVGDVLILTK----PLGTQTAMALSRIPEEFKDL----IS---ITEEERDYIINKAIEIMTTSNR-YALKALRKAEERVG-----DKIANALTDITGFGILGHSNEMAKNSN-VLIEI--NLLPCIKRT-PELSRLF-------------GHA-----------LLDGYGAETAGGLLISAKEEYKDNLIDELEKA-------KCY-AFEVGRVVKKGEGKAV--LSK----------DVK--VIEI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_Archaea_Methanopyrus_kandleri -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MS-RKKSLVEMADLHGCACKLPQGDL-----EDLLKGVE--LPE--EGGRVE--------------------------------VG-VG----DDAAVIRVD----------------------------------GGYVIQ-----------------------------SVD-----FFTPI-HPDPYTQGRIAANNSINDVFAMG--ATEVLSVLVVSGFPR-----------------ELPEEDAREMLQGFADQCREVDALIV-GGHTIM------NPWPILGGCVTGFAERY------VTVGGAEPGDVLYLTK----PLGTQPAMAALRLPEDVRKQ----F----LTDSELEEAVDLAVEVMTEPLK-DAAEAAL------------EVGVHAMTDVTGFGLKGHAGEMAEASG-VRVVI--ERLPVIPGT-TELSRAL-------------GYG-----------LERGESAETAGGLLVAVPEEHAEDLEDAFERR-------DVW-YRRIGRVEEGSGVEVR--GDV-----------EE--VEDYP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_Archaea_Haloterrigena_turkmenica ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTDRSDV-ADVRLTEYADLHGCSCKVGRSDL-----DDLLREAG--LTE--SRDELL--------------------------------FG-VG----EDAAARQLT------------------------------D---DLALVS-----------------------------TVD-----FFTPI-IDDPYDFGRVAACNAASDAFATG--AVDNLDCLAVLGLPQ-----------------ELT-TAAPMILAGIADAIDGMGGVVA-GGHTII------SPWPFAGGAVSATAPPEE----LLTSQRATTGDRLYLTK----PLGTQSAMGALRVSDDEFVD----VV-AEAAGRSVRTIGDEAVAWMTTPNR-AAAVAAR-------------DVASAATDITGFGLVGQAEVLADNAD-VGIEV--TRLPVIEGT-EGLSALF-------------GYG-----------LEDGESAETSGGLLLSVPPSHTATLESRLDDA-------GVF-YRQIGRVTDGDGVSLR--DPT----------VEP--IARAER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SPS2_Mus_musculus ------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAEA-------AAA------------GASGETM-----AALVAAEGSLGPAGWSAGRSFSNYRPFEPQTLGFS-PSWRLTSFSGMKGCGCKVPQETL-----LKLLEGLT--RPALQPPLTSGLVGGQEETVQEGGLST------RPGPGSAFPSLS-IG----MDSCVIP--------------------------------LRHGGLSLVQ-----------------------------TTD-----FFYPL-VEDPYMMGRIACANVLSDLYAMG--ITECDNMLMLLSVSQS-------------MSEKEREKVTPLMIKGFRDAAEEGGTAVT-GGQTVV------NPWIIIGGVATVVCQQNE----FIMPDSAVVGDVLVLTK----PLGTQVAANAHQWLDNPEKWNK--IK-MVVSREEVELAYQEAMFNMATLNR-TAAGLMH------------TFNAHAATDITGFGILGHSQNLAKQQK-NEVSFVIHNLPIIAKM-AAISK-----ASG-------RFG-----------LLQGTSAETSGGLLICLPREQAARFCSEIKSSKYG----EGHQAWIVGIVEKGNRTARI--ID------------KPRVIEVLPRGASAAAAAAPDNSNA---------------------------ASEPSS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SPS2_Dictyostelium_discoideum --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSISIKDKKEE-LLCRLTDFTKLKGCGCKVPQAEL-----LSLLDGIG--GGI-------------GYDCSISQTK-------------FPDIVM-IQ----TTDVSLKLFKNK----------NKLIKLYIYIYL----IYIYIFFIIFL-----------------------------KKK-----FFFPL-VDDPYFQGKIACANVLSDLYSFG--IEDCDNMLMLLACSTD-------------MTAEQRQWSSKLMKQGFNDQAICAGSKVS-GGQTVK------NPWPIVGGVATSILKTNE----FIKPVNAVPGDVLVLTN----PLGTQFCVNFHQWLSKPKRGEK--IN-TITNAKECEQVFNYATLSMAKLNR-VGAKLMK------------NYNAHAATDVTGFGILGHSTNLAQNQL-LPIRFEIHTLPIIKHM-KKLEDH----LNH-------PFK-----------LLKGTSAETSGGLLISMSRENAEAFCKEIYEI-------EKQPAWIIGDVID----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SPS2_Caenorhabditis_elegans ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNRIERILEGFDPVSNGLD-EDFVLTKLTGMKGCGCKVPRNVL-----LQLLQTFK--TDLVIN----------------------------------NDEVD-IG----LDSCVIP--------------------------------LRHPGLRLVQ-----------------------------TTD-----FFYPL-IDDPYIMGRVTCANVLSDLYAMG--VSECDNMLMLLAVAID-------------LNEKQRDIVVPLFIQGFKDAADEAGTKIR-GGQTVR------CPWLLLGGVATSVAHESE----IIKVDQAVPGDVLILTK----PIGGQVAVNSYEWIKKKNGKI---EE-LNLEIPKIEKAFKQVCEQMSRLNR-NAAKLLH------------KYDAHSSTDVTGFGLLGHAENLARVQK-QPMEFIIEKLPIIEYM-DEIADKMIAKGGE-------GFK-----------LYQGTSAETSGGLLIAMSEENAKKYIAELSSL-------DNAPAWIIGKVTAKTTDSSI--ARI----------LPDAVRISVPSHI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ SPS2_Danio_rerio --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-----SGSEPPSGDSGGAGGYAVFYPAGYQALNPEEHGLD-RGFRLTAFSDMKGCGCKVPQETL-----LKLLQGLE---PDRPPGEDGGLGTGVGDETADFGLVS------A----AQGPRLG-IG----MDSCVIP--------------------------------LRHGGLSLVQ-----------------------------TTD-----FFYPL-VEDPYMMGRIACANVLSDLYAMG--ITECDNMLMLLSVSQK-------------MNEKERDLVLPLMMKGFRDAAEEGGTSVT-GGQTVI------NPWIIIGGVASVVCQPND----FILPDGAVPGDVLVLTK----PLGTQVAVNAHQWLDIPEKWNK--IK-LVISREEVEQAYQEAMLNMATLNR-TAAALMH------------KFNAHAATDITGFGIIGHARNLAKQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_Bacteria_Escherichia_coli ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSE-NSIRLTQYSHGAGCGCKISPKVL-----ETILHSEQ--AKFVDPNLLVG--------------------------------NE-TR----DDAAVYDLG------------------------------N---GTSVIS-----------------------------TTD-----FFMPI-VDNPFDFGRIAATNAISDIFAMG--GKPIMA-IAILGWPIN----------------KLSPEIAREVTEGGRYACRQAGIALA-GGHSID------APEPIFGLAVTGIVPTER----VKKNSTAQAGCKLFLTK----PLGIGVLTTAEKK------------------SLLKPEHQGLATEVMCRMNI-AGASFAN------------IEGVKAMTDVTGFGLLGHLSEMCQGAG-VQARVDYEAIPKLPGV-EEYIKLGAVPGGTERNFASYGH---LMGEMPREVRDLLCDPQTSGGLLLAVMPEAENEVKATAAEF-------GIE-LTAIGELVPARGGRAM--VEI----------R------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ SelD_Bacteria_Syntrophomonas_wolfei ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-KQTRLTEMVRAAGCAAKIGPEAL-----ESILKDFP---LPVHPDLLIG--------------------------------IE-SR----DDAAVLKLD------------------------------E---EKALIQ-----------------------------TID-----FFTPM-VDDPFIFGQIAATNALNDIYAMG--GTPILA-LNVVCFPE-----------------CADLQVLRKILEGGLSKVLEAGALLV-GGHTVD------DNEPKYGLAVSGLVHPQK----IIANNGAQPGDLLFLTK----PLGNGVIATSIKA------------------EMVSGEAYKEAIKWMSMLNR-ESSQAMM------------EVGVNAATDITGFGLMGHLYEMAWGSD-VQVEVFADKVPFMEGT-LEYAGLGLIPGGAYNNRDYLKDKVEYAGNIDPLIRDLFFSPETAGGLLIAVAEKKAGELLQVMEKR-------GSF-CNLIGRVRGEHFSPIR--VRD----------SRG--AEGQNP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- SelD_Bacteria_Ralstonia_eutropha -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA-ESIRLTQYSHGAGCGCKISPKVL-----DVILAGSG--AQNLDPRLWVG--------------------------------NA-SR----DDAAVYAID------------------------------GDDSGRGVVS-----------------------------TTD-----FFMPI-VDDPFDFGRIAATNAISDIYAMG--GDPLMA-IAILGWPVN----------------VLPPEVAREVVAGGRKACDDAGIPLA-GGHSID------APEPIFGLAVTGMVDRMH----MKRNDTATAGCRLYLTK----PIGIGVLTTAEKK------------------GLLRPEHAHVARDWMCVLNR-PGSAFGR------------LAGVRAMTDVTGFGLLGHLVEMADGSG-LTARLDYAAVPVLPEI-RRYIDAGCVPGGTQRNFDSYGH---RIGTLTDEQRALLCDPQTSGGLLVAVEPAGEAAFLDACTRL-------GLD-LAPIGELAARGEHAVE--VA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ SelD_Bacteria_Ammonifex_degensii ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-ERIRLTALTTSSGCAAKIGPGTL-----ARILQDLP---LIKDPRLLVG--------------------------------IE-TS----DDAGVYLLT------------------------------E---EIALIQ-----------------------------TVD-----FFTPV-VDDPFFFGQIAAANALSDVYAMG--GKPLTA-LNIICFPTA----------------CGDLEILAQILRGGAEKVKEAGVVLL-GGHSVE------DKEPKYGLAVTGIVHPAK----VLTNRGSRPGDRLVLTK----RLGTGIVVTALKA------------------DLAPAELVAEATQEMATLNQ-AAAEAMQ------------EVGVNACTDITGFGLLGHALEMARASG-VHLVIKASQLPLFPQV-LDFAAMGLIPAGAYANRQFVAERVEISPAVPPELQDILFDPQTSGGLLISVPAERLEALLEALKRK-------GVATVAVIGEVTEGPPGTIE--VIP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HypE_Methanococcus_maripaludis ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNITRMHGAGGT--------------VMQKLIKETIL------GN--LENTKIEGGIGLESLDDASTI---------------------------------PLGD-KEIVF-----------------------------TVDGHTVQPIFF----PGGDIGRISVCGTVNDLSVMG--AKPVAL-SLSIVLPEG-F----------------DIEKLDKIMKSINEACKEAGVAII-TGDTKVS-N---VDDIIISSAGIGLVDSGK----AVRDCGMREGDVIIVTG----NIGEHG--LTILLTREGFE------------FESDLKSDVAPVNGIVQSVL-NA----------------GF-EINAMKDPTRGGLADSLNEMAEKSD-LGILIYEDQIPISDEV-QAIGEAL----GI-------D-------------PLTVANEG---KVVMSVNEKDSEKILEILKAHPLGKN------AKIIGNVTSEHKG--V--LMETIVGKRIV----DTPMGDPIPRVC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HypE_Methanocaldococcus_jannaschii ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKITRMHGAGGK--------------VMQELIKDVIL------KN--LEITSVNGGIGLESLDDSATI---------------------------------PIGD-KEIVF-----------------------------TVDGHTVKPIFF----PGGDIGRLAVSGTVNDLAVMG--AKPLAL-SLSLIIPEG-F----------------NLEDLEKIVKSINETSKEAEVAII-TGDTKVSDG---VDDIIISTAGIGIVDRGK----AIRDCNVQEGDAIIVSG----NIGEHG--LAILLSREGFD------------FETNIKSDVAPINKLIERVL-EE----------------GI-QINAMKDPTRGGLADALNEMAEKSN-IGITIFEDKIPISDEV-QSICDIL----GL-------D-------------PLTIANEG---KVVMAVKKEDAERCLEILREHPLGKN------AEIIGYATKEHKG--V--IIETIVGRRIV----DMPIGDPIPRVC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HypE_Sulfolobus_acidocaldarius -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--------------RFGKLNPKAFL------HRLPIGNCVVCPGIG----EDDAYV---------------------------------KVEG-EYLVI-----------------------------HSD-----PITE----TGKDAGYLSVVVACNDVNMKG--VECKSI-ITTLLLHD--------------------EESLSPVIEGISEACNILKCKVV-GGHTELTKG---LDRDIVVTTAFSFSNH------VLRLSDVRENDYIVLFG----NPGIEG--TWILANEYEDKL-------SRLGVSRNLIERAKRFKYLIPVQD-KAMK-------------VKD-YAISMHDATEGGIYQALLEVAQATN-LRVVVEKEKIPLLEET-VEITKAL----NI-------N-------------PYTLISSG---AFIVITRD---YEKLTRLGGVLIGKLKRDTPALEVNGEVYTEDFEEELVRFEGYNNGGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HypE_Mycobacterium_rhodesiae ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPDTPAEADTAIDMESWVCPAPLRDS-------PNIVMGHGGGGA--------------MSAELIEHLFL------PA--FGRAAE-AGMGDSAVL--------------------------------------DVGN-VRLAF-----------------------------STDSFVVKPLSF----PGGTIGDLAVNGTVNDLAMAG--ARPLVM-STAFILEEG-T----------------SLDDLARVAQAVGTAAMAAGVKLV-TGDTKVVDAG-HGDGVYINTAGIGLIDERA----DIRPQRATEGDVVIVSG----DIGVHG--VAVMSCREGLE------------FGTTVASDTAPLHGLVAAMI-DT----------------GA-DIHALRDPTRGGVAATLNEIAKTAD-VGISLDERTFPIPAEV-RDACGLL----GL-------D-------------PLYVANEG---KLLAFVAPTEADRVLTAMRAHPLGAH------ATVIGRCVAEHPK--MVSAKTALGGTRVV----DLPIGEQLPRIC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HypE_Geobacter_metallireducens --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNK-------DLILLGHGSGGK--------------LSHQLLDDLII------PT--LSGIPL-AGQNDAAVV--------------------------------------EHGG-QRLAF-----------------------------TTDSYVVDPIFF----PGGNIGSLAVNGTVNDLAMMG--ARPLFI-SAGLIVEEG-F----------------SRTELAGILASMRGAADAAGVRIV-TGDTKVVPRG-KADRIFINTSGIGAVEHDF----AINGANARAGDVVIING----TIGDHG--IAVMAEREGLD------------LRTAIRSDCAALNDLVAEII-AA---------------GGD-AVHVLRDPTRGGVATTLKEIALQSD-KTITLREETLPLNGAV-KGVCSIL----GL-------D-------------PLYVANEG---KLLAVVAPEAAERVLTRIKGHRLGRD------AAIIGHVAEGGG---RVQMETAVGGMRAV----EMLAGEQLPRIC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- HypE_Escherichia_coli ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-------NNIQLAHGSGGQ--------------AMQQLINSLFM------EA--FANPWL-AEQEDQARLDLAQL---------------------------------VAEG-DRLAF-----------------------------STDSYVIDPLFF----PGGNIGKLAICGTANDVAVSG--AIPRYL-SCGFILEEG-L----------------PMETLKAVVTSMAETARTAGIAIV-TGDTKVVQRD-AVDKLFINTAGMGAIPANI----HWGAQTLTAGDVLLVSG----TLGDHG--ATILNLREQLG------------LDGELVSDCAVLTPLIQTLR-DI-----------------P-GVKALRDATRGGVNAVVHEFAAACG-CGIELSEAALPVKPAV-RGVCELL----GL-------D-------------ALNFANEG---KLVIAVERNAAEQVLAALHSHPLGKD------AALIGEVVERKGV--R--LAGLYGVKRTL----DLPHAEPLPRIC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ThiL_Methanocaldococcus_jannaschii ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDEMKV-------------------IEIIKK-------TLKFSNENIVKGID----DDCAII---------------------------------KIDENFYLVA-----------------------------TTDMMVKKAHIPSIL-SPYEIGGRILTANVSDIASMG--AKPLAF-LVSISLSKEEA----------------NEKFIKELYSGLDDFSKLYDCPVV-GGDTNR------GDELILSGTAFGITDNP-------IYRRGKVGDDICVTN----DLGRVYCALTLYYMLKENKI-------SYKEFERLCQKYPKIIEKLRKPIA-RIKEGL-----L-----MNK-LINGCCDISD-GLGKEITYFKNFEI-YSDRIFK---LIPEDV-IEFCDAF----NL-------N-------------PIKVALNSGEEFELLFTTSKF-NKVKDSLKG---------YSKIYKIGKIIEDGQFI--------DGEEFYG----GGYIHKW---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ThiL_Methanococcus_vannielii ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNEFDI-------------------INI-IS-------KNISYKNGVERGIG----DDCAVF---------------------------------KLEN-QHLVI-----------------------------TTDMMFRSTHFPEIL-TPFQIGMRIVTANVSDIAAMC--AKPLGM-VISMGFDKP------------------DLKFIDEMSKGMNFISKEYGCPIV-GGDTNK------SKELTLSGTAFGITNNP-------IYRGGNLGNEICITG----TIGRVFCALKILEMSKNGII-------DKLKFEKLIEEFPEIIKKLSEPKA-RVLEGI-----S-----LNN-VVTSCSDISD-GLSKDLNHVGFFEI-YSKELLK---AVPKDV-VEFSEKF----DI-------N-------------LIDIALNSGEEFELLFTVKDF-KNAKKVLKG---------INTVTKFGKVVESGKTV--------DGNNITF----EGYVHKW---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ThiL_Escherichia_coli ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MACGEFSL-------------------IARYFD-------RVRSSRLDVELGIG----DDCALL---------------------------------NIPEKQTLAI-----------------------------STDTLVAGNHFLPDI-DPADLAYKALAVNLSDLAAMG--ADPAWL-TLALTLPD--V----------------DEAWLESFSNSLFDLLNYYDMQLI-GGDTTR------GP-LSMTLGIHGFVPMGR----ALTRSGAKPGDWIYVTG----TPGDSAAGLAILQNRLQV---------------ADAKDADYLIKRHLRPSP-RILQGQ-----A-----LRD-LANSAIDLSD-GLISDLGHIVKASD-CGARIDLALLPFSDAL-SRHVEPE-------------Q-------------ALRWALSGGEDYELCFTVPEL-NRGALDVALGHL------GVPFTCIGQMTADIEGL--CFIRDGEPVTLDW----KGYDHFATP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ThiL_Acidothermus_cellulolyticus ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTSNAATLLGPG----DDAAVV---------------------------------AVPD-GRVVV-----------------------------TTDLLVDGRHFRRDWSTPYDVGRKAAAQNMADIAAMG--AVPVAL-VVGLATPPD-I----------------PAFWAERLADGLREEAARTGAAVV-GGDVVR------SDTVVVAVTALGDLQGRT----PVTRGGARPGDVVAVIG----RLGWAEAGLAALRRGFRT--------------------PRAAVEAHRRPEP-PYEAGP-----I-----AADRGATSMIDVSD-GLLGDLGHVAVASR-IRIDVESAALPVADVV-AEVAAAC----GV-------D-------------PLRWVLTGGEDHALAATFPDR-AAVPDGW---------------VVIGRAHEPAGETGDVVVDG---RRYPG----SGFSHFAADA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ThiL_Mariprofundus_ferrooxydans ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGEFDL-------------------IDRCFA------GRGGQPRTFTRLGIG----DDASVH---------------------------------QPAAGMELVV-----------------------------STDTSLAGVHWPTDL-PLAVAADRAVCAALSDLAAMG--AEALCC-WLN--VMA--E----------------DAGAVAQMGDGATAALARFDVELV-GGDTTR------SSCNALAVTVAGQLPAGS----AMRRSGAQAGDNIWLCG----CVGFHASGLKQWINDCK---------------------DGSFVEYFTGVVP-MLKQGV-----R-----LREQGVQCCMDISD-GLLQDATHLACASD-VGMEIELSLLPDWPQL-VDEIGEA-------------Q-------------ALQNAAHGGEDYALLFTAPAS-MRFTDACMIGRCREL--PGVSLMLGGQP-----------------VSVEK----GGYDHFQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ThiL_Vibrio_shilonii -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSGEFSL-------------------IDKYFA-------HKQQQRKDVVLAQG----DDCAIV---------------------------------APPADSHIAI-----------------------------STDTLVSGTHFLADA-DPAWIAHKALASNISDLAAMG--ASPAWV-SMGISLPE--V----------------NERWLERFCNAFFSLADYYGIQLI-GGDTTK------GP-LAITLTVQGTLPQGK----ALTRSGANSGDWIYVTG----HLGDAKAGLDVILEKNIS---------------ANTELNRVLEKRHFEATP-RVLAGI-----T-----LRD-IASAAIDISD-GLISDLGHILKRSD-VGARIDVDLLPVSSEL-KQFVESD-----D-------I-------------AKQYALTSGEEYELCFTVPEA-NRGQLEIALS--------NTPFTCIGQITGTGY-L--DLHSNDQPLDWQL----GGFDHFKVSQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PurM_Sulfolobus_islandicus ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M--------SEEYKKAGVDLERL-------RNYHN---------------------AISQIISS--------------TYKNTIVGAG----HYSGVI---------------------------------KIGN-LNIAM-----------------------------HTDGVGTKTSLALQTGIIKPVGIDCVAMNVNDLICVG--AKPVAL-VDYIALEK--P----------------MDNVINEIINGIVQGAKDADVEVI-GGETAIMPDVIRG--FDLSCTAIGVVDNLK------TGVDIKPGDYILGLE----SNGIHSNGYSLVRKLIEEGK---------ISLDEYKRELLKPTRIYAKQVL-EVM-----------------NMIKGAAHITGGAFTKL-KRLTSYK--IVLN---MPEPP-EIF-KII-EKA----GV-------PH-----------EEMYKVFNMGIGIVLFISEELM-KEVKTKLER--------YGT-VYELGRVYNGNGITIKTYKNEILRV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PurM_Thermococcus_barophilus ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLTYAQAGVDERKA-------QKALR---------------------SIISLARKTFR-------FRRGKIGEPVEDIG----HYAALM---------------------------------DFGD-FYLAM-----------------------------TTDGVGTKILVAEAVGKFDTIGIDMVAMNVNDLICVG--AEPIAL-VDYLAVRD--P----------------NDKIFREIAKGLYEGAKQSGIAIV-GGETAVMPDLING--FDLAGTAIGIVGKEK----VITGNKIKPGDVVIGIE----SSGIHSNGLTLARKLLIPKYGLEYE----FEGKTLWEHLLEPTRIYVKPIL-ELLE---------------KVEVKGLAHITGGGLLNL-KRLTKYG--FSLE---MPPIR-GIF-KLI-YEN----GV-------PL-----------EEMFKVFNMGIGFVVIVSQGEK-EETLQILNN--------YYL-SYEIGKVIKKPKIKIENYKIMF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PurM_Methanosarcina_mazei ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSEK--------HLTYADSGVDIKEE-------EKTVK---------------------TLID----KLS-------YVRKGIGAPLTGIG----HYAGLL---------------------------------DFGE-YALAM-----------------------------TTDGVGSKVLIANEMQRWNTVGIDCIAMNVNDLLAIG--AEPVAF-VDYLALEK--H----------------EEGFAEQIGEGLLKGAEISRMSIV-GGETATLPDIIKG--FDLAGTCLGYLKKED----IIEGGRVRVGDVIVGIP----STGVHSNGYTLVRKIIQESGYYYHDPCPYDSSKTIGDDLLEPTRIYIEVLD-V-LK---------------ACEVHGLAHITGSGLLKL-RRVTKLG--FDFY---DPLEPQEIF-KFLQKEG----GV-------DD-----------LEMYRTFNMGMGFLIILPEKDA-AKAAEITG-------------GKIVGKIVESGIRVKDLVIE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ PurM_Escherichia_coli --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTDKT--------SLSYKDAGVDIDAG-------NALVG---------------------RIKGVVKKTR-------------RPEVMGGLG----GFGALYALPQ-----------------------------KYRE-PVLVS-----------------------------GTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQG--AEPLFF-LDYYATGK--L----------------DVDTASAVISGIAEGCLQSGCSLV-GGETAEMPGMYHGEDYDVAGFCVGVVEKSE----IIDGSKVSDGDVLIALG----SSGPHSNGYSLVRKILEVSGCDPQTTE--LDGKPLADHLLAPTRIYVKSVL-ELIE---------------KVDVHAIAHLTGGGFWENIPRVLPDN--TQAVIDESSWQWPEVF-NWLQTAG----NV-------ER-----------HEMYRTFNCGVGMIIALPAPEV-DKALALLNA--------NGENAWKIGIIKASDSEQRVVIE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PurM_Shewanella_oneidensis --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSTPT--------PLSYKDAGVDIDAG-------NALVN---------------------NIKAAVKRTR-------------RPEVMGNLG----GFGALCELPT-----------------------------KYKQ-PVLVS-----------------------------GTDGVGTKLRLAIDYKKHDTVGIDLVAMCVNDLIVQG--AEPLFF-LDYYATGK--L----------------DVETATAVVNGIGEGCFQSGCALI-GGETAEMPGMYEGEDYDLAGFCVGVVEKAD----IIDGSKVAAGDALIALA----SSGPHSNGYSLVRKVLEVSQADPQQD---LNGKPLIQHLLEPTKIYVKSLL-KLIE---------------ASDVHAMAHITGGGFWENIPRVLPEN--CKAVIQGDSWQWPAVF-SWLMENG----NI-------AE-----------YEMYRTFNCGVGMIVALPADKV-DAALALLAA--------EGEQAWLIGAIAAREGNEEQVEIL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ PurM_Geobacter_lovleyi ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSKP--------RATYKEAGVDIEAG-------NSFVQ---------------------KIKPLVKSTF-------------RPEVMTEIG----GFGGLFSLNAA----------------------------KYKN-PVLVS-----------------------------GTDGVGTKLKLAFLADRHDTVGIDLVAMCVNDIVVQG--AEPLFF-LDYLATGK--L----------------DPDKAAQIVAGIAEGCRQAGCALI-GGETAEMPGFYADGEYDIAGFTVGVVEKDQ----IIDGSSITVGNKLIGIG----SSGLHSNGYSLARRIIFDRMGLAINSPLPDSTKTVDEELLTPTRIYVRSVM-NLLK---------------DFRINGIAHITGGGLLENVPRILPKG--CSASFKLGSWDMPSIF-TTLQEAG----NV-------EQ-----------NEMYRTFNMGIGMVLAVAAADV-DDILSRLNG--------LGEQAWLIGEVKSMSKNQTEQVVLV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PurL_Pyrobaculum_islandicum -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGLTQRELEIIRERLGREPTAAELAFFTSHWSEHCSYKST-------KMWLREL---------------------------------------PGSAPWVVRGRG----TDAPLV---------------------------------EVAHGLYVSF-----------------------------KIE-----SHNHPSAVDPYNGAATGVGGIIRDILTVG--ATPIAL-LVNLHFGPPEDPH--------------AKWIFSNVIKGISDYGNRVGVPVV-GGETWFDEDF--TYTPIVLATCVGVVEAEA----VP-KGYVEPGDYIVVAGLGADRSGLGGSAFASKTLEGGED------------LGAIQVADPLMGKKLIDVVK-EV-----------------SRCVKFIKDLGGGGLATALAELSHWFS-LGVEFHLDKLHVRDA-------------SA-------L-------------PEELLISETQERLIFVISPRDLPCLEEALRK--------YEVPYSIPGRFVKSDRVL-----VMWKGVKIVD--IPIS-LADGAPEILWPQEP------YQPSDIPEIPEPPID-KAIDIVLSSPNVAKKESIYM-RFDFDVGVRTAVKPG-------EGDAAVLKLYQRGQLGLVVKGDANPRYTFLDPRLGAANAFVKAYRNVAVVGGVPLAAVDSINV---------GSPERPQVYWRFVQAVQGLKEAATELEVPIVGGKVSLYNEYMG---------RPIKPTVAVVVLGKIDDVSKAN-RALWHDGDKIYIWGVTKGEVGGSEYLKRVHGILAGRPPSIDYAAEKEIVAVIQS--WLGKISGATDVGLGGLITALAKMAINSGIGGEIDVCKAPAET----TRLDYLLFSESNGRFIATGAEGPGVA-----IGEAYGEEFVVKCGGTLIYKRG--VEELKRLMSL----------------- PurL_Methanosarcina_acetivorans --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLPEEDLKIIRKELGREPTLVEQGCFLNLWSEHCSYRSS-------APLLKTF---------------------------------------TSTGENVLIGPG----DDAAII---------------------------------KFEDGYVLAI-----------------------------GME-----SHNHPSYVDPYNGAATGIGGIVRDIISMG--ARPIAL-MDPLYFGPLDTPK--------------NLFLFEQIIKGIAGYGNCIGVPVV-NGETFFDRRY--SGNPLVNVVAVGLCKEEN----VTTSRSQKAENKLILAGSSTGKDGLGGASFASRDLSESAEA---------EDRPSVQVGDPYTEKLVMEMTL-EAIE---------------KGYVKSCKDLGAAGLGGASSELAAKGG-LGARIIADAVPQREP-------------NM-------N-------------AYEILLAESQERMLFEVAPEDVDAVLALVQK--------YDLNGAVVGYLTKEPTYT-----VEFGGEIVAD--IPIAFLTGGAPTCEKPSEAPTLREEGK-----KPETPEDLKVAFLKVLSSYNIASKEWIYR-QYDHEVQLRTVVKPG-------EDS-GVLR-I-TGTKGIALTCGCQPRATLLDPYNGGKTAIIENSMNLAVKGAEPLAIVNCLNF---------GNPERPETYWQFENAVLGLGDEARKLSIPVVGGNVSLYNESDEF-------KTAIPPTPSIGMIGKVDLEIPLPSGFFAKDGDSIILVGETTPEMGGSEYYACMDSGNAGMVPAVPENAPELIKAII-EAVKSGKLSSAHDLSLGGIGAGLARMCRSM--GAKVDLSELA-GE----TQADELLFSEAPARALLAISEPEAVRE----ILKDVPHAVIGKVGGETLEIKG---KNFELSVSLKEIAEAYGSLTRFMMG- PurL_Methanococcus_maripaludis MQTINAENNGKIYRIEIDTKEKSSEATG--IEKKLSELGY--DVSVDVSKVYTINYDFSIEDVEKI-ANSLHNPVTEIPRINVPSNNKFDWTLELGFLPGVTDNVANTTTEIINDLLKINIGLS-KVFSSKVVYLSGNLAKHDVEKIAEE-LINILIERYHIKTYDNYVKDCGMDYIIPKVNLTSEPKVIEISLNVSDDELIEIGKKGILDPETGERRGPLALDLDYITAIKKYYQKEGRNPTDIELEALAQTWSEHCKHTIF-------ASQIDDIE--------------------EGIFKKYIRNATNEIREELGEKDFCISVFS----DNSGGI---------------------------------IFDDEWMVTD-----------------------------KAE-----THNSPSALDPFGGAITGIVGVNRDTVGFGLGALPVAN-KYGFCVGRPEDTKIIYRGQNKSNPSLLPRRILDGIVHGVNVGGNQSGIPTP-NGFVYFDDTY--KGKPLVFVGTIGLIPRKLPDGRLSHEKAAENGDNIVIIGGRVGKDGIHGATFSSEAMDEGSP------------ATAVQIGDPITQKKLSDAVIKEARD---------------RELYNSITDNGAGGISCSVAEMAEECG--GFVVELEEVPLKYP-------------GL-------E-------------PWEIWISESQERVTLSVSDDKLEEFMDLMKI--------RGVEAVVIGKFNNTDRAV-----VNYNGKTIMD--LNMDFLHNGLPKRKLITKPYPYKTEE------PEITVKNQLKTFEKILGNHNNCSFEYISK-QYDHEVQNNSVIKPLQGKGRV-NGAASVIRPLLSSQKGLVMSQSLFPRLSEISCYDMAACALDTAIRNCVAVGGNINHIAIMDNFCWCS-------SDEPERLYQLKDAAKSCYDYAKIYLTPLISGKDSMFNDFKGFDENNNQIKISVHPTLMMSALGVIDNVEKTNSMDLKLKDDLIYVIGETKDECGGSEFYHA-FGEVGGKSPKVDAKSARKLYEKMYELSQKGIFSSCASVAAGGLAITLAKMAISGMLGLEADLSKAPNEN----LDFGKIMYSETQSRFIVTIAPENEKEFEN--LMKEFKIGKIGKVTEKEFVIKN--NEDIVITSSLENMDEVYRSRFEDF--- PurL_Moorella_thermoacetica -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEPEIYRRMGLTDAEFEKVKAILGREPNYVELGMFAVMWSEHCGYKSS-------RSVLKLF---------------------------------------PTKAPWVLQGPG----ENAGIV---------------------------------DIGDGQAVVF-----------------------------KIE-----SHNHPSAIEPFQGAATGVGGIVRDIFAMG--ARPIAV-LNSLRFGPLDDSR--------------TRYLMGGVVGGIAFYGNCLGLPTV-AGEVYFEPSY--ACNPLVNVMAVGLIEQKN----IRRGTAAGVGNAVMLIGARTGRDGIHGATFASEELSEASE----------ERRPSVQVGDPFREKLLIEACL-EIIN---------------EDLIIGMQDMGAAGITSSSCEMAARAG-TGMEIDIALVPRREE-------------GM-------T-------------PYEVMLSESQERMLLVPKKGAEERIRAICRR--------WGLEAVIIGRVTGDGLMR-----IMENGRVVAE--VPAKALTDQCPVYERERRRPAYLDEVRQRDLSRLPEPEDYGRVLLGLLAAPNLASKEWVYR-QYDYMVRTDTVAGPG-------GDA-AILR-VKGTSKGLALTVDGNGRYCYLDPERGGAIAVAEAARNLACVGARPLAITDCLNF---------GNPEKPEVAWQFYQAVSGMSRACEVLRTPVTGGNVSFYNETES---------GAIYPTPVVGMVGLLPDIEKRCGIGFRREGDLLILMGETYPEIGGSEYLATFHGLVAGEPPALDLEREKAVQALVREVIAAGLATAAHDCAEGGLAVALAESALAGGLGAEVEL---A-SD----LRPDFLLFSESQSRILLAVAPEARDRVLDLAREKGVRASVIGRCGGHSLVVRI--NGRTLFNLSLEEMGKQWRESIPVLMAR PurL_Geobacter_lovleyi ----------MSSRVEVALKDGVRDSRGERIKREIEHFLHLKVKQVRTIDVYTVDAALTREELEAAASGPFCDPVIQSYSVDLPQASGFDWAVEVGFRPGVTDNIGRTAGEAVSYLIQRPLADSEAVYSSVQYLLTGDLSNEQVEKIATGLLCNTLIQRYSIMSAADFMARRGFPVTVPKVTGETKGQVREIDLEVSDEELLRISKDGVLALTLEEMKIIQTHYRDPQVLAERSKQGLGSKPTDVELECLAQTWSEHCKHKIF-------AGTVQYEDENGN------------KQEIKSLFKSYIQRVTKEVRQNMGDKDFCLSVFK----DNAGVI---------------------------------TFDENNSLVF-----------------------------KVE-----THNSPSALDPYGGALTGIVGVNRDPFGTGQGSKLIFN-TDVFCFADP------FYDKPLPARLLHPRRIFEGVVEGVEHGGNKSGIPTV-NGSIVFDERF--AGKPLVFCGTAGMMPAR-VNGIPGHEKSIKPGDLIVMAGGRIGKDGIHGATFSSEELNENSP------------VTAVQIGDPITQKRMFDFLI-RARD---------------KGLYRFITDNGAGGLSSSIGEMAGECN--GCRMDLAKAPLKYP-------------GL-------N-------------PWEILISEAQERMSMAVPPEKLDEFMAMSKR--------FGVESTVLGEFTDSGTFH-----IQYGEATVAW--LPMEFMHEGLPPMQIPAKWQPPVTPEA-----PAQHKEDWTADLLGLLGQLNICSKESVVR-RYDHEVQGGSVVKPFTGVTNDGPSDAAVVRPILDSYKGVVVSHGICPRYSDIDAYHMAANAIDEALRNYVAVGGNPEHWAGLDNFCWCDPVLSEKTPDGPYKMAQLVRANQALLDYCVPLNLPLISGKDSMKNDFYD-----GSTKISIPPTLLFSVIGTIPDIRNAVTMDFKRPGDIICLLGATKDELGGSEYLAM-QGYTGNKVPKVDLASALARYKALHQAIMNGLVASCHDLSDGGLAVALAESSFSGGFGCRVELGNVHFEGDQRYRTDEVLLFSESASRLLVTVHPAQWSAFEE--AMAGTTFSQIGQVADTDMVSIAGLEGKTVLHSSLKQLKEAWQATLREL--- other_Methanopyrus_kandleri --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNL-------RELARELRSFEGV---------TRKHPVKTVVEGLLE------PLDVTFEGEVIADVG----EDAAAV---------------------------------KVGD-DILLI-----------------------------AADGIWGKLIDR----DPWWAGYCAVLVNVNDVLAMG--GRPVGL-VNVLSTSDV--------------------DVCREILEGMREGAWKFSTPVL-GGHTHPD-----TPYTAVDAAIVGVTDEEH----LVLSSTAEEGDLIVFVI----DLNGRPYPE------------------YPLNWDT----TTMKDPDYLRRQM-EAV--V-----E-----ASK-LVKAGKDVSNPGLVGTLAMMLEASGCLGAEVWLDSIPKPEDV-D----------------------------------MVTWLKMYPGMGFVYAVDSE-RDVRAIRRVL---SD--ARLEVSVIGEVTEDGVVK----VSEGDESARVFDFREDR-ILGVSPR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- other_Methanobrevibacter_smithii -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMDGVFISDF-------KNLVKAVQEFEGV---------TRKSSIDTVTSLLTE------SYN--VSGDVVIDIG----DDASAI---------------------------------DIGNNQVVLI-----------------------------AADGIWGQIMNV----NPYWAGYCSVLVNVNDIAAMG--GKPLAM-VNIMSVKHD--------------------EIYENLLAGIKDGCLKFGVPMV-GGHLHPD-----GEVDSLGVAIVGIAKKDK----LITSFGAEVGDKIIVAI----DLDGKPHEM------------------FELNWDT----TYDKDKQLVQDQI-TAVQYL-----A-----ERD-YIKSGKDISNPGILGTLEMLLETSD-KGAIVNLEDIPKNENI-S----------------------------------WENWLKSYPGSGFIFTANEE-N-CEFIKKYL---KD--YSIEANVVGEVTGECSLY----LVNGDGEKLEVFNQKTNPVFKSKKE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- other_Methanococcus_maripaludis ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGDFMDL-------SKLADELRNFEGV---------TRKKEIKNVVNNFNF------QED--YEFDIVVDFG----DDAAII---------------------------------GIDDENAVLL-----------------------------AADGIWGKLLET----DPFWAGYCAVLVNANDIAAMG--GRSIGM-TNIIGIKDC--------------------DKGRDLLKGLKEGVSKFGIPVV-GGHTHPD-----AQCNVLDISITGLVKRDN----VLRSDAAKTGDKIVFAY----DLDGKIHET------------------FNLNWDT----TSMKSKKYVRDQL-KVLEII-----G-----EEH-LANSCKDISNPGGLGTLGMLLEVSK-KGAMVDVSKIPVPEDV-S----------------------------------LNHWLKMYPGSGFVFTAPEN-K-TKDLIERL---EF--TGIASAVCGEVKNDRKFM----ITDGNEKTVFFDFEKEY-ICGC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------; END; BEGIN TREES; Tree ATP_binding_superfamily = (((((PurL_Geobacter_lovleyi:0.48561,PurL_Methanococcus_maripaludis:0.57570):0.53731,(PurL_Pyrobaculum_islandicum:0.70088,(PurL_Moorella_thermoacetica:0.54192,PurL_Methanosarcina_acetivorans:0.52613):0.14774):0.09592):0.69942,(other_Methanobrevibacter_smithii:0.48678,(other_Methanococcus_maripaludis:0.45533,other_Methanopyrus_kandleri:0.53681):0.14795):0.70192):0.21860,(((((PurM_Escherichia_coli:0.12940,PurM_Shewanella_oneidensis:0.20422):0.28844,PurM_Geobacter_lovleyi:0.28613):0.48949,(PurM_Methanosarcina_mazei:0.55369,(PurM_Sulfolobus_islandicus:0.68646,PurM_Thermococcus_barophilus:0.32272):0.18255):0.12834):0.84238,((((ThiL_Escherichia_coli:0.27838,ThiL_Vibrio_shilonii:0.44210):0.30635,ThiL_Mariprofundus_ferrooxydans:0.95279):0.23281,ThiL_Acidothermus_cellulolyticus:0.82921):0.25189,(ThiL_Methanococcus_vannielii:0.39698,ThiL_Methanocaldococcus_jannaschii:0.43550):0.60081):0.31465):0.10015,(((HypE_Mycobacterium_rhodesiae:0.34027,(HypE_Escherichia_coli:0.65450,HypE_Geobacter_metallireducens:0.29975):0.16211):0.37586,(HypE_Methanocaldococcus_jannaschii:0.09173,HypE_Methanococcus_maripaludis:0.20686):0.20622):0.34983,HypE_Sulfolobus_acidocaldarius:1.42309):0.41150):0.07328):0.19642,((((SelD_Bacteria_Escherichia_coli:0.23421,SelD_Bacteria_Ralstonia_eutropha:0.30075):0.51256,(SelD_Bacteria_Ammonifex_degensii:0.35239,SelD_Bacteria_Syntrophomonas_wolfei:0.40795):0.21416):0.33285,(((SelD_Archaea_Methanoplanus_petrolearius:0.39462,SelD_Archaea_Methanocaldococcus_jannaschii:0.46308):0.13456,(SelD_Archaea_Methanopyrus_kandleri:0.38120,SelD_Archaea_Haloterrigena_turkmenica:0.66605):0.12706):0.16089,(SPS2_Dictyostelium_discoideum:0.57839,(SPS2_Caenorhabditis_elegans:0.54338,(SPS2_Mus_musculus:0.25468,SPS2_Danio_rerio:0.11865):0.21721):0.12085):0.60823):0.13969):0.32239,(((SelD_like_Sulfolobus_tokodaii:0.19938,SelD_like_Metallosphaera_cuprina:0.22810):0.08496,SelD_like_Acidianus_hospitalis:0.15877):0.35756,(((SelD_like_Thermoproteus_uzoniensis:0.22635,SelD_like_Pyrobaculum_aerophilum:0.15196):0.39625,SelD_like_Caldivirga_maquilingensis:0.40567):0.07949,SelD_like_Vulcanisaeta_distributa:0.35632):0.18436):1.06342):0.08621); END;