#NEXUS BEGIN TAXA; TITLE Taxa; DIMENSIONS NTAX=233; TAXLABELS Kryptolebias_marmoratus_Km.CYP1A Kryptolebias_marmoratus_Km.CYP1B1 Kryptolebias_marmoratus_Km.CYP1C1 Kryptolebias_marmoratus_Km.CYP1C2 Kryptolebias_marmoratus_Km.CYP1D1 Kryptolebias_marmoratus_Km.CYP2AD12 Kryptolebias_marmoratus_Km.CYP2AD12.iso Kryptolebias_marmoratus_Km.CYP2K38 Kryptolebias_marmoratus_Km.CYP2K39 Kryptolebias_marmoratus_Km.CYP2K40 Kryptolebias_marmoratus_Km.CYP2K41 Kryptolebias_marmoratus_Km.CYP2K42 Kryptolebias_marmoratus_Km.CYP2K43 Kryptolebias_marmoratus_Km.CYP2K44 Kryptolebias_marmoratus_Km.CYP2K45 Kryptolebias_marmoratus_Km.CYP2K46 Kryptolebias_marmoratus_Km.CYP2K47 Kryptolebias_marmoratus_Km.CYP2K48 Kryptolebias_marmoratus_Km.CYP2K49 Kryptolebias_marmoratus_Km.CYP2K50 Kryptolebias_marmoratus_Km.CYP2K51 Kryptolebias_marmoratus_Km.CYP2K52 Kryptolebias_marmoratus_Km.CYP2N22 Kryptolebias_marmoratus_Km.CYP2N23 Kryptolebias_marmoratus_Km.CYP2P16 Kryptolebias_marmoratus_Km.CYP2P17 Kryptolebias_marmoratus_Km.CYP2P18 Kryptolebias_marmoratus_Km.CYP2P19 Kryptolebias_marmoratus_Km.CYP2P20 Kryptolebias_marmoratus_Km.CYP2R1 Kryptolebias_marmoratus_Km.CYP2U1 Kryptolebias_marmoratus_Km.CYP2X24 Kryptolebias_marmoratus_Km.CYP2X25 Kryptolebias_marmoratus_Km.CYP2X26 Kryptolebias_marmoratus_Km.CYP2X27 Kryptolebias_marmoratus_Km.CYP2Y9 Kryptolebias_marmoratus_Km.CYP2Z6 Kryptolebias_marmoratus_Km.CYP2Z6.like Kryptolebias_marmoratus_Km.CYP3A176 Kryptolebias_marmoratus_Km.CYP3A177 Kryptolebias_marmoratus_Km.CYP3B10 Kryptolebias_marmoratus_Km.CYP4F128 Kryptolebias_marmoratus_Km.CYP4T17 Kryptolebias_marmoratus_Km.CYP4T18 Kryptolebias_marmoratus_Km.CYP4V2 Kryptolebias_marmoratus_Km.CYP5A1 Kryptolebias_marmoratus_Km.CYP5A2 Kryptolebias_marmoratus_Km.CYP5A3 Kryptolebias_marmoratus_Km.CYP5A4 Kryptolebias_marmoratus_Km.CYP5A6 Kryptolebias_marmoratus_Km.CYP7A1 Kryptolebias_marmoratus_Km.CYP7C1 Kryptolebias_marmoratus_Km.CYP8A1 Kryptolebias_marmoratus_Km.CYP8A2 Kryptolebias_marmoratus_Km.CYP8A2.like Kryptolebias_marmoratus_Km.CYP8B1 Kryptolebias_marmoratus_Km.CYP8B14 Kryptolebias_marmoratus_Km.CYP11A1 Kryptolebias_marmoratus_Km.CYP11C1v1 Kryptolebias_marmoratus_Km.CYP17A1 Kryptolebias_marmoratus_Km.CYP17A2 Kryptolebias_marmoratus_Km.CYP19A1 Kryptolebias_marmoratus_Km.CYP19A2 Kryptolebias_marmoratus_Km.CYP20A1 Kryptolebias_marmoratus_Km.CYP21A1 Kryptolebias_marmoratus_Km.CYP24A1 Kryptolebias_marmoratus_Km.CYP26A1 Kryptolebias_marmoratus_Km.CYP26B1 Kryptolebias_marmoratus_Km.CYP26C1 Kryptolebias_marmoratus_Km.CYP27A1 Kryptolebias_marmoratus_Km.CYP27A3 Kryptolebias_marmoratus_Km.CYP27B1 Kryptolebias_marmoratus_Km.CYP27C1 Kryptolebias_marmoratus_Km.CYP46A1 Kryptolebias_marmoratus_Km.CYP46A2 Kryptolebias_marmoratus_Km.CYP46A4 Kryptolebias_marmoratus_Km.CYP46A5 Kryptolebias_marmoratus_Km.CYP51A1 Oryzias_latipes_OlCYP11A2 Oryzias_latipes_OlCYP11C1 Oryzias_latipes_OlCYP17A2 Oryzias_latipes_OlCYP19A1 Oryzias_latipes_OlCYP19A2 Oryzias_latipes_OlCYP1B1 Oryzias_latipes_OlCYP1C1 Oryzias_latipes_OlCYP1D1 Oryzias_latipes_OlCYP20A1 Oryzias_latipes_OlCYP26A1 Oryzias_latipes_OlCYP26B1 Oryzias_latipes_OlCYP26C1 Oryzias_latipes_OlCYP27A1 Oryzias_latipes_OlCYP27C1 Oryzias_latipes_OlCYP2AD7 Oryzias_latipes_OlCYP2K27 Oryzias_latipes_OlCYP2K28 Oryzias_latipes_OlCYP2K29 Oryzias_latipes_OlCYP2K30 Oryzias_latipes_OlCYP2N.like1 Oryzias_latipes_OlCYP2N.like2 Oryzias_latipes_OlCYP2N18 Oryzias_latipes_OlCYP2N20 Oryzias_latipes_OlCYP2P12 Oryzias_latipes_OlCYP2P13 Oryzias_latipes_OlCYP2P15 Oryzias_latipes_OlCYP2U1 Oryzias_latipes_OlCYP2X14 Oryzias_latipes_OlCYP2X20 Oryzias_latipes_OlCYP2Y6a Oryzias_latipes_OlCYP2Y6b Oryzias_latipes_OlCYP2Z5 Oryzias_latipes_OlCYP3A38 Oryzias_latipes_OlCYP3A40 Oryzias_latipes_OlCYP3A40.like Oryzias_latipes_OlCYP3A56.like Oryzias_latipes_OlCYP3B5 Oryzias_latipes_OlCYP4T12 Oryzias_latipes_OlCYP4V2 Takifugu_rubripes_TrCYP1A1 Takifugu_rubripes_TrCYP1B1 Takifugu_rubripes_TrCYP2AD.like Takifugu_rubripes_TrCYP2K1 Takifugu_rubripes_TrCYP2K.like1 Takifugu_rubripes_TrCYP2K.like2 Takifugu_rubripes_TrCYP2N.like Takifugu_rubripes_TrCYP2P.like Takifugu_rubripes_TrCYP2U1 Takifugu_rubripes_TrCYP2X.like Takifugu_rubripes_TrCYP2Y.like Takifugu_rubripes_TrCYP2Z.like Takifugu_rubripes_TrCYP3A27 Takifugu_rubripes_TrCYP3A30 Takifugu_rubripes_TrCYP3A40 Takifugu_rubripes_TrCYP4T10 Takifugu_rubripes_TrCYP4V2 Takifugu_rubripes_TrCYP11C1 Takifugu_rubripes_TrCYP17A1 Takifugu_rubripes_TrCYP17A2 Takifugu_rubripes_TrCYP19A1 Takifugu_rubripes_TrCYP19A2 Takifugu_rubripes_TrCYP20A1 Takifugu_rubripes_TrCYP26A1 Takifugu_rubripes_TrCYP26C1 Takifugu_rubripes_TrCYP27C1 Danio_rerio_DrCYP1A Danio_rerio_DrCYP1B1 Danio_rerio_DrCYP1C1 Danio_rerio_DrCYP1C2 Danio_rerio_DrCYP1D1 Danio_rerio_DrCYP2AA1 Danio_rerio_DrCYP2AA2 Danio_rerio_DrCYP2AA3 Danio_rerio_DrCYP2AA4 Danio_rerio_DrCYP2AA6 Danio_rerio_DrCYP2AA7 Danio_rerio_DrCYP2AA8 Danio_rerio_DrCYP2AA9 Danio_rerio_DrCYP2AA11 Danio_rerio_DrCYP2AA12 Danio_rerio_DrCYP2AD2 Danio_rerio_DrCYP2AD3 Danio_rerio_DrCYP2AD6 Danio_rerio_DrCYP2AE1 Danio_rerio_DrCYP2K6 Danio_rerio_DrCYP2K8 Danio_rerio_DrCYP2K16 Danio_rerio_DrCYP2K17 Danio_rerio_DrCYP2K18 Danio_rerio_DrCYP2K19 Danio_rerio_DrCYP2K20 Danio_rerio_DrCYP2K21 Danio_rerio_DrCYP2K22 Danio_rerio_DrCYP2K31 Danio_rerio_DrCYP2N13 Danio_rerio_DrCYP2P6 Danio_rerio_DrCYP2P7 Danio_rerio_DrCYP2P8 Danio_rerio_DrCYP2P9 Danio_rerio_DrCYP2P10 Danio_rerio_DrCYP2R1 Danio_rerio_DrCYP2U1 Danio_rerio_DrCYP2V1 Danio_rerio_DrCYP2X6 Danio_rerio_DrCYP2X7 Danio_rerio_DrCYP2X8 Danio_rerio_DrCYP2X9 Danio_rerio_DrCYP2X10.1v1 Danio_rerio_DrCYP2X10.2v2 Danio_rerio_DrCYP2X12c1 Danio_rerio_DrCYP2X12c2 Danio_rerio_DrCYP2Y3 Danio_rerio_DrCYP2Y4 Danio_rerio_DrCYP3A65 Danio_rerio_DrCYP3C1 Danio_rerio_DrCYP3C2 Danio_rerio_DrCYP3C3 Danio_rerio_DrCYP3C4 Danio_rerio_DrCYP4F3 Danio_rerio_DrCYP4T8 Danio_rerio_DrCYP4V7 Danio_rerio_DrCYP4V8 Danio_rerio_DrCYP5A1 Danio_rerio_DrCYP7A1 Danio_rerio_DrCYP7B1 Danio_rerio_DrCYP7D1 Danio_rerio_DrCYP8A1 Danio_rerio_DrCYP8B1 Danio_rerio_DrCYP8B2 Danio_rerio_DrCYP8B3 Danio_rerio_DrCYP11A1 Danio_rerio_DrCYP11C1 Danio_rerio_DrCYP17A1 Danio_rerio_DrCYP17A2 Danio_rerio_DrCYP19A1A Danio_rerio_DrCYP19A1B Danio_rerio_DrCYP20A1 Danio_rerio_DrCYP21A1 Danio_rerio_DrCYP24A1 Danio_rerio_DrCYP26A1 Danio_rerio_DrCYP26B1 Danio_rerio_DrCYP26C1 Danio_rerio_DrCYP27A1.4 Danio_rerio_DrCYP27A3 Danio_rerio_DrCYP27A5 Danio_rerio_DrCYP27A6 Danio_rerio_DrCYP27A7 Danio_rerio_DrCYP27B1 Danio_rerio_DrCYP27C1 Danio_rerio_DrCYP39A1 Danio_rerio_DrCYP46A1.1 Danio_rerio_DrCYP46A1.2 Danio_rerio_DrCYP46A1.3 Danio_rerio_DrCYP46A1.4 Danio_rerio_DrCYP51 ; END; BEGIN CHARACTERS; TITLE Kryptolebias_Fig._2_Km_CYP; DIMENSIONS NCHAR=994; FORMAT DATATYPE = Protein GAP = - MISSING = ?; MATRIX Kryptolebias_marmoratus_Km.CYP1A -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALMILPIFGAVSVF------EALLALVVLCLVYLALKRYSTKIP--------------------------EGLRRLPGPRALPVIGNMLELGR-----------------KPYLSLTEMS------KRYGEVFQVQLGSRPVVVLSGYETVKQALTKQG---DDFSGRPDLYSFSFINDGKSL--AFSTDKAGIWRTRRKLAYSALRSFSNLEGTTSEYSCVLEEHICKESGYLIKELNNVMKT-----------EGKFDPFRYIVVSVANVICGMCFGRRYDHHDQEL----LGLINLSEDFVKVTGSG--NPADFIPALQYLPDKA---MKKFVDINSRFCNFVQKIVSEHYITF-------DKDNIRDITDSLIDHCEDRK-----------------------------------------LDENSNVQISDEKIVGIVNDLFGAGFDTISTGLSWAVMYLVAYPEIEERLFTEIKEKIGLDRT------------------------------------------------------PTLSDRNNLPLLEAFILELF-RHSSYLPFTIPHCATKDTSLNGYFIPK------DTCVFINQWQINHDPELWEDPSSFIPD------RFLSDDGT-EV-----NKLDGEKVVIFGLG-----------RRRCIGE-VIARNEVFLFLAIIIQKLHFYQLPGEPLDLTPE---YG--LTMKHK--------RCHLGVKLRDENAQ-------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP1B1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDQSLEVWLT---------PRSVLVVSAVLLVS--LWVRLRH--------------------------RSGSGLPGPFSWPLIGNAAQLGN-----------------APHLFFARLV------QKFGNVFQIRLGSQAVVVLNGA-AIRQALIKQG---LDFAGRPDFTSFRFIADGDSM--AFGT-VTERWKTHRRVAQSTVRMFSTGNPQTRRT---FEQHVLCEFRELLRLFVERTRA-----------ERFFQPMTFLVVSTANVMSAVCFGKRYSYQDDEF----RDVVGRNDKFTQTVGAG--SIVDVMPWLQYFPNPIRTMFEEFKKLNQDFSLFIRDKVLEHRKTL-------ESSTFRDMTDAFIVALD-R------------------------------------------IPDRTGPPAAKDDVSPAIGDIFGASQDTLSTALQWIVLILVKFPQMQERLQQEVDRVVDRDRL------------------------------------------------------PSAEDMSRLPYVMAFIYEMM-RFTSFVPLTIPHSTIKDTSIMGHSVPK------NTVIFINQWSVNHDPTYWSNPENFDPE------RFLDPQG--SL-----NKDLTSSVLIFSLG-----------RRRCIGE-ELSKMQLFLFTALLAHQCHIRPDPTRTLSLDYS---YG--LTLKPH--------AFSIAVSLREDMKLLDEAAAQASSGKTPLDAQTKQMEENSKTEG-------------------------------------- Kryptolebias_marmoratus_Km.CYP1C1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALDTELDLKSSSLIREWSGQVHPALVASFVFLFCLEACLWVRNL-------------------------RLKRRLPGPFAWPVVGNAMQLGQ-----------------MPHITFAKLA------KKYGNVYQIRLGCSDVVVLNGDRAIHQALIQHS---TEFAGRPNFVSFQMISGGRSM--TFTN-YSKQWKAHRRVAQSTLRAFSSANSQTKKA---FEQHVLAEATELVQVFLRQSAN-----------GQYFYPAYEFTVAAANIMCALCFGMRYGHDDQEF----RTLLHRVDKFGETVGAG--SLVDVMPWLQSFPNPVRNVYEAFKSLNEEFFTYVKDKVVKHRETF-------NPEVTRDMSDAIIRAI--EH-----------------------------------------GEGSILS---KEFVEATVTDLIGAGQDTMSTVMQWIVLLLVKYPDMQAKLQQLIDKVVGPDRL------------------------------------------------------PSVEDRSSLALVDAFIFETM-RFTSFVPVTIPHSTTSDVVIEDLYIPK------DTVVFINQWSVNHDPQKWKDPHVFDPT------RFLDENG--AL-----DKDKTNSVMIFSTG-----------KRRCIGV-QIAKVQVFLFTAVLLHQCNFESNPSEPLTFDCS---YS--LTLKPN--------RFCVRTKLRGKMLGVVSPA--------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP1C2 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAQMDAELDLKSSSIIREWSGKVHPALVASFVFLFCLEACLWVRNL-------------------------RLKRRLPGPFAWPVVGNALQLGQ-----------------MPHITFSNLA------KKYGDIYQIRLGCSDIVVLNGARVIRQALIEHS---TEFAGRPNFVSFQLVSGGKSL--TFTS-YSKQWSIHRKIAQTTIRAFSTANSQTKKA---FEHQIVAEVKELVGIFLKLSAQ-----------GQYFNPGHELTVAAANVICALCFGKRYGHDDPEF----RALLHQVDQFGQTVGAG--SLVDVMPWLQSFPNPVRSIFKSFKCLNEEFFEFVRSKVEEHRKTF-------DPKVIRDMSDAIIDAFN-ET-----------------------------------------DSVTELT---KDYTEATVADLIGAGMDTVSTALHWILLLLAKHPDIQTKLQELIDKVVGRNRL------------------------------------------------------PSVEDRPHLPYLDAFIYETM-RFTSFVPVTIPHSTTTDVSINGLKIPK------DTVVFINQWSVNHDPLKWKDPHIFNPS------RFLDIND--SL-----DRDITNNVMIFSAG-----------KRRCIGD-QIGKTQIFLFFAILLHQCSFEKCPDEDFSLNCS---YG--LTLKPL--------NYKITAKLRGELLKSG------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP1D1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGLILSGN------LPVSEDPSASLS------TVTVALCLLTLVLVAIRIQQSQR---------------------DSRLDHTRSPAPPGPTPWPLVGNLLQMGD-----------------QMHLCLTHLG------HQYGDVFQLRLGSLNVVVLSGFTTIRQALVRQG---EEFAGRPELFTFSAVADGNSM--TFSEKYGPAWLLHKKLCKNALRSFSQAEPRGSGATCLLEEHICAEATEMVEVIREQAVK--------DSDKMGIDPSLSLVTCVANVVCSLCFGRRYDHDDKEF----LTIVNINNEVLKLFAAG--NLADFFPVFRYFPSPS---LKKLVQYIRRMNGFMERRIEEHVSSF-------DKNYIRDITDALIALCEDRE-----------------------------------------DNKET-SLLSNSQIIRTVIDIFGAGFDTIFAGLQWSLLYLIKFPDIQDKIHQEIDDHIGSARL------------------------------------------------------PRFSDKPKMPLTEAFIHEVF-RHSSYVPFTIPHCTTRDAILNGYFIPK------DTCVFINQHQVNHDVDLWGDPEKFRPE------RFLGPSG--QL-----NKELTEKVLIFGVG-----------KRRCVGD-GFARLEMFVFLTTLLHGLKLESVPGQKLDLSAD---FG--LTMKPH--------PYRITVSSRF------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP2AD12 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIFQALFAQIDFTSWLLLVFLLLLLMDVVK-NWRPRN-----------------------------FPPGPWAVPFLGNVFTGV-------------------DFKSINKLT------KEYGPVLSLRKGSERFVFISGYKMVKEALVNQL---DSFIDRPIVPLFDVIYKGL----GITMSNGYLWKKQRKFANCHLRYFGEGHKS-------LEKYIEVECSFLCEAFK-------------EEQGKPFNPHYMMKMAVSNIICSVVFGHRFEYSDPSL----RKVLELDNEAIVLSGS---LRTQLYDVIPGLMKYLPGPHQTVHANYREILSFLMKEIEKHQEEW-------NPDDPRDYIDVYLAEMKKHK-----------------------------------------EDPLA--GFNIETLQFCTLDLIEAGTESAANTLRWALVYMMNFPEIQEKVQAEIDRVIGQSRQ------------------------------------------------------PTIADRPNLPYTEAVVHESQ-RIGNIVPMGFPKMASKDTTLGGYFIPK------GTAITTNLASVLFDKNEWETPDVFNPG------HFLDSEG---------KFLRKEAFLPFSAG-----------KRVCIGE-NLAKMELFLFFTTLLQHFTFVPVPGEMPSLEGV---MG--FTYSPQ--------EFRMLAVPR------------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2AD12.iso --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIFQALFAQIDFTSWLLLVFLLLLLMDVVK-NWRPRN-----------------------------FPPGPWAVPFLGNVFTGV-------------------DFKSINKLT------KEYGPVLSLRKGSERFVFISGYKMVKEALVNQL---DSFIDRPIVPLFDVIYKGL----GIALSNGYLWKKQRKFANCHLRYFGEGHKS-------LEKYIEVECSFLCEAFK-------------EEQGRPFNPHYMMKMAVSNIICSVVFGHRFEYSDPSL----RKVLELDNEAIVLSGS---LRTQLYDVIPGLMKYLPGPHQTVHANYREILSFLMKEIEKHQEEW-------NPDDPRDYIDVYLAEMKKHK-----------------------------------------EDPLA--GFNIETLQFCTLDLIEAGTESAANTLRWALVYMMNFPEIQEKVQAEIDRVIGQSRQ------------------------------------------------------PTIADRPNLPYTEAVVHESQ-RFGNIAPMGFPKMASKDTTLGGYFIPK------GTAITTNLASVLFDKNEWETPDVFNPG------HFLDSEG---------KFLRKEAFLPFSAG-----------KRVCIGE-NLAKMELFLFFTTLLQHFTFVPVPGEMPSLEGV---MG--FTYSPQ--------EFRMLAVPR------------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2K38 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MELLKDFVFFLFSSPTTVVGGVFLLLVFYFVFVGST-SGDGRK-----------------------------EPPGPRPLPLLGNLLQLDL----------------SRPYRTLCEFS------KNYGSVFTVYFGPRKVVVLAGYETVKEALVSYA---EEFGDRDISPIFN-DITRGHG---ILFSNGDSWKEMRRFALYTLRDFGMGKRV-------VEEKILEECGHLIQMFE-------------NQKGKPFDTAHPLNYATSNIICSVVYGSRYEYNDPRF----RNMVSRASENIRLSGS---AQIQIYNMFPWLFRWIK-NCQLMLKNVEMTIRDMKAIVTQLKETL-------DPQRCRGLVDCFLIQKQRDE-----------------------------------------DSGVKDTHFHEENLIFTATNLFAAGTETTATTLRWSLLLMAKYPHIQDQVREELLRVIG-NRA------------------------------------------------------ARVEDRKNLPFTDAVIHETQ-RLANIVPMSIPHKTSQDVTFQGYFIKK------DTIVIPLLTSVLHDEREWESPHTFNPS------HFLDKEG---------KFIKRGAFLPFSAG-----------RRVCLGE-SLAKMELFLFFTSLLQRFHFTPPPGVSEDELDLTPAIG--FTIPPS--------PHKLCAVSHQ------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP2K39 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLEDIFQSP--TSVSLFGVFVALLLLHLLHS-SF-SSQERR-----------------------------EPPGPRPLPVFGNLFQVDL----------------KRPDQSLFNLS------KKYGPVFQIYLGLKKVVVLAGYRTVKQALVNQA---EEFGNIDISPIIY-DFNQGHG---IALANGDSWKEMKRFALTTLRDFGMGKKM-------SEDLIIEECGYLIKEFE-------------QLEGETFDRSQTIDYASSNVVSALTFGKRFDYEDPIF----QTMVERNHETLCLIGS---ASIQLYNLIPWLGPFLK-NWRDFMKNMEDMKADIRKLITDLKETL-------DPEVCRCFIDAFLIRKKHLE-----------------------------------------DSDIIDSHYHDENLLFSVINFFGAGTETTATTLKWSLLYMAKFPHIQDRVQEELSRVVG-SCQ------------------------------------------------------IQIDDRKNLPYTNAVIHETQ-RFANIGPFSVPHATTKDVTLQGYFIKK------GTTVLTLLTSVLYDENEWESPHSFNPS------HFLDDEG---------KFIRRDAFMPFSAG-----------RRACLGE-SHAKMELFLFFASLLQNFHFIPPPGVSEDDLDLKPVLG--CTLNPK--------PQQLCAVLRR------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP2K40 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLEDIFQSP--TSVSLFGVFVALLLLHLLYS-SF-SSQKRP-----------------------------EPLGPRPLPVFGNLFQVDL----------------KRLDQSLFNLS------KTYGPVFQVYFGPKKVVVLAGYRTVKEALLNQA---EEFGNREITPLFY-DFNQGHG---IVFSNGDSWKEMRRFALTTLRDFGMGKKM-------SEEIIIEECGYLIKEME-------------QYGGEAFNNTQAINYAASNVISALMFKKRFEYKDPVF----QTMVEKDNETIRLTGS---VSIMIYNLCPWLGPFLK-NWRDMMKNIEANKAHLRKLISDLKETL-------DPEICRCFVDAFLIQKKHLK-----------------------------------------DFDEKSSHYHDENLLYSVMNLFAAGTDTTATTLKWGLLYMAKFPHIQDRVQEELSRVVG-SRQ------------------------------------------------------IQTEDRKNLPYTDAVIHETQ-RFANIGPLAIPHKTTRNVTFQGYFIKK------DTTVFPLLTSVLYDENEWESPHSFNPS------HFLDDEG---------KFIRRDAFMPFSAG-----------RRACLGE-SLAKMELFLFFTSLLQRFHFTPPPGVPEDELDLKPVVG--MTLAPK--------PQQLCAVRRR------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP2K41 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLEDIFQSP--TSVSLFGVFVALLLLHLLHS-TF-SSQKRP-----------------------------EPPGPRPLPVFGNLFQVDL----------------KRLDQSLFNLS------KTYGPVFQVYFGPKKVVVLAGYRTVKEALLNQA---DEFGNREITPILN-DLTQGHG---ILFSNGDSWKEMRRFALSTLRDFGMGRKM-------SEEIIIEECGYLIKEME-------------QYGGEAFNNTQAINYAASNVISALMFGKRFEYKDPVF----QNMVERDNETIHLMGT---ASIMMYDLFPWLGPFFK-NWRNLMKNNEDSLADLKKLIADLKETL-------DPEICRCFVDAFLIRKKHLK-----------------------------------------DDEVKNSHYHDENLLYTVDDLFAAGTDTTATTLKWGLLYMAKFPHIQRCVQEELSRVVG-SRQ------------------------------------------------------VRIEDRKNLPYTDAVIHEIQ-RFANIAPMALPHTTSNDLTFQGYVVKE------GTTVFPLLTSVLYDESEWESPHSFNPP------HFLNDEG---------KFIRRDAFMPFSAG-----------RRACLGE-SLAKMELFLFFASLLQHFHFTPPPGVSEDEVDLKPVVG--LTLTPK--------PQRLCAVHRL------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP2K42 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLEDIFQSP--TTVSLFGVFVALLLLHLLYS-SF-SSQNRP-----------------------------EPPGPRPLPVLGNLFQVDL----------------KTIHHSLFILS------KKYGSVFQVRLGPKKVVVLAGYRTVKEALVNQA---EAFRNIEITPLFH-DINQGHG---IILANGDSWKEMRRFALTTLKDFGMGRKM-------SEEIIIEECGYLIKEFE-------------QFEGKAFSNTQVISYATSNVISALVFGKRFDYKDPFL----NIMMERNYENIRLMSS---ASIQIYNVIPWIGPLLK-NWRDFKKNIGNSLADIKKIIVDLKKTL-------DPEVCRCFVDAFLIHKKQLE-----------------------------------------DSENRNSHYHDNNLLYSVMNLFGAGTETTATTLKWGLLYLVKFPHIQDRVQEELSRVVG-SRQ------------------------------------------------------VRIEDRKNLPYTDAVIHEIQ-RVANVAP-VLPHTTTKDVTLQGYFLKE------GTTVLLLLLSVLSDESEWESPHSFNPS------HFLDDEG---------KFIRRDAFMPFSTG-----------PRACLGE-SLARMELFLFFASLLQHFRFTLPPGVSEDELDLKPVEG--FTLGPK--------PQQLCAVQRQ------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP2K43 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLEDIFQSP--TSVSLFGVFVALLLLHLLHS-TF-SSQNRP-----------------------------EPPGPRPLPVFGNLFQVDL----------------KRLDQSLFNLS------KKYGPVFQVYFGPKKVVVLAGYRTVKEALVNQA---DEFGDRDICPLFY-DLNQEYG---ILFSNGDSWKEMRRFALSALRDFGMGRKM-------SEEIIIEECGYLIKEFE-------------QFEGEAFDNTQAINYATSNVISALMFGKRFEYKDPVF----QTMVERDNETIHLMGT---ASLVIYNMIPWMGPFLK-NWTDLMKNMENNKADIRKIIADLKQTL-------DPETCRCFIDAFLIRKNQLE-----------------------------------------DLEMKSSHYRDENLLYSVINLFAAGTDTTATTLKWSLLYMVRFPQIQDRVQEELSRVVG-SRQ------------------------------------------------------VRIEDRKNLPYTDAVIHEIQ-RLANIVPMALPHATSKDITLQGHLIKE------GTTVFPLLTSVLYDESEWESPHSFNPS------HFLDDEG---------KFIRRDAFMPFSAG-----------RRACLGE-SLAKMELFLFFASLLQHFQFTPPPEVSEDELDLKPVVG--LTLAPK--------PQKLCAVCRL------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP2K44 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFED-LLSP--ISVSLFGVLVALLLLHLLYS-SF-SSNERP-----------------------------EPPGPRPLPLFGNLFQVDL----------------KWLDKSLFELS------KKYGPVFQVYFGPKKVVVLAGYKAVKQALVNQA---VEFGNRDITPAFY-DLTKSHG---IIFSNGDSWKEMRRFALTALRDFGMGKKM-------SEEIIIEECHYLIEELE-------------QFEGKAFENTKPFNYAASNVISALIFGRRFDYKDAIF----QAMVRRENEIIRLTGS---ASVWIYNAFPWLAPLLK-NWRDLIKNVKGNETDAMKLIADLKESL-------DPEVCRCYVEAFLIHKKQLE-----------------------------------------DSEMKNLYYHDENLLYCVTNLLEAGNDTTANTVKWGLLHMAKNPHVQDRVQEELSRVVG-SRQ------------------------------------------------------IRTEDRKNLPYTDAVIHEIQ-RLANIFPLALPHATSTDVTFQGYFIKQ------GTTVFPLLTSVLYDESEWESPHSFNPS------HFLDKEG---------NFIKRDALMPFSAG-----------RRACLGE-SLAKMEVFLFFTSLLQHFHFTPPPGVSEDEVDLTPAVG--FSLCPR--------PQKLCAVRRK------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP2K45 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFED-LQPP--TSVLLLGVIVALLLLHFFCS-NI-FIQERR-----------------------------EPPGPRPLPVFGNLFQVDL----------------KWLDKSLFKLS------KKYGPVFQVYFGPKKVVVLAGYRTVKQALVNHA---VEFGTREITPTFN-DLHKGHG---IAFSNGDSWKEMRRFALTTLRDFGMGKKM-------SEKIIAKECCYLIEEFE-------------EFEGKAFNNTKPINYAATNVISSLMFGKRFDNKDQVF----QAMVERDNEIVRLSGT---ASLWLYNIFPWLGPFFK-NWRDFMKILEDNEKTVKKIIADLKETL-------DPEVCRCFVDAFLIRQKHLE-----------------------------------------DSEITNLHYHDDNLLYSVMNLFEAGNDTTANTVKWGLLYMAKFPHIQDRVQEELSRVVG-SRQ------------------------------------------------------VRTEDRKNLPYTDAVIHETQ-RLAKNLPVGLPYTTSKNVTFQGYFIRA------GTTVFPLLTSVLYDESEWESPHSFNPS------HFLDDEG---------KFIRRDAFMPFSAG-----------RRACIGE-SLARMELFLFFASLLQHFRFTPPPGVSEDEVDLAPVVG--FSLCPR--------PQKLCAVRRR------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP2K46 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFED-LQS-----VSLFGVFVALLILHFLYS-SF-YSQETQ-----------------------------EPPGPRPVPLFGNLFQMDL----------------RRLNQSLFDLS------KKYGPVFQVYFGSQKVVVLSGYRTVKQALVNHA---NEFGDREITPAFF-DLTKGFG---VVFSNGDLWKEMRRFALTTLRDFGMGKKR-------SEDIIVEECQYVINEFE-------------QLEGKPFDNTKFFNYAATNIVSVLMFGKRFDYKDQVF----RAMVERDNELIRLLGT---ASISVYNCFPWLGPFLK-DWRDYIKHVKASREDVKQIIADMKETL-------DPEVCRCFVDAFLIRKKQLE-----------------------------------------ESENS--HFNDDNLLYSVINLIEAGNDTTATTLKWSLLYMAKYPHVQDRVQEELSRVVG-SRQ------------------------------------------------------VQSEDRKNLPYTDAVIHETQ-RFADLVPLALPHTTCQDVTLQGYFIKK------GTTVFPLLTSVLYDENEWESPHSFNPS------HFLDDEG---------KFIRRDAFMPFSAG-----------RRACLGE-GLARMELFLVFTSLLQRFCFTPPPGVSGDEVDLTPVVG--LTLSPR--------PQKLCAVQRN------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP2K47 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGEVDVFLWSFS--PVSLLVAPVFLLLISLYFSSSFSSQKPRP-----------------------------GPPGPRPLPLLGNLLQLDF----------------KRPDKTFVELS------KKYGSVFTFYMGLKKAVVLTGYQTVKEALVNYA---DEFGERDVPAVAK-EANLNHG---IVWSNGDSWKEMRRFALTNLKDFGMGKKA-------CEDKIIEESQSLVQEFK-------------KFKGEAFSTDRIITCAVSNIICSVIYGSRFEYEDPAF----QTITNRTSIAVKFSAS---PKIQFYNLYPGIGKLFISARKKMSDIYAANKKDHLKLLNNLKETL-------NPQMCRGVADVFMVPDLHLQ-----------------------------------------ESGISNSNYTDENLLATVMNLFAAGTETTTTTLRWSLLYMTKYPKIQAKVQEELNTVVG-SRQ------------------------------------------------------VQVQDKQNLPFTNAVIHETQ-RLANIVPLALAHRTSQDVTFQGHFIEK------GTIVFPVLTTVLHDESEWEKPYDFHPA------HFLDKDG---------NFTKRDAFLPFSAG-----------RRMCPGE-SLAKMELFIFFTTFLQHFRFTPPPGVSEEDLDLTPLPGGTGTLRPQ--------PHKLCAVSLM------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP2K48 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSKESRK-----------------------------EPPGPTPLPLLGNLLQLDL----------------KKPHETLIEFS------KKYGSVFTVHFGPQKVVVLAGYRTVKEALVNHD---EAFGVRGPLQIVD-ELNQGHG---VLWTNGNTWREMRRFSLTNLKDFGMGRKA-------CEDKIIEECQHLVEVLK-------------NFKGEAFDTNQSLNYAVSNIIASMIYGSRFEYEDLEF----TSMVDRINRSGTLLGS---PSVQVYNLYPFLFKWIA-NRKESHNVAAANRKQNFALIRHLKQTL-------NPQMCRGFVDAFLVHKKKLE-----------------------------------------ESGISDNEFSDDNLVMTVANLFAAGSETTSSTLRWGLLFMAKFPDIQGKVREELKRAVG-DRQ------------------------------------------------------VQAADRMNLPYTNAVIHETQ-RMANILPESLPHKTSRDITFHGHLIRK------GTTVYPLLMSVLRDANEWEKPDTFYPP------HFLDKDG---------KFAKRDAFMPFSAG-----------HRMCLGE-SLARMELFIFFTTLLQHFRFTPAPGVLEEDLDLTPRTG--LSLTPV--------PHKLCAVSCM------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP2K49 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVVLDGLLQSFC--SASLLVALVVLL-TYFLFSSSFSSKNPSK-----------------------------EPPGPRGLPVLGNLLQIDL----------------KRPHHTFQELS------KKYGSVFTVYLGPKKVVVLTGYKTVKEALVQYD---EEFGDRDSLPILR-EFNKGHG---ILWSNGDSWREMRRFTLTNLRDFGMGRKV-------CEDKIIEECQRLTEVFK-------------NFNGKPFETMQPINYAVSNIICSMVYGSRFEYSDPEF----TSMVDRTNRNIQLTGS---ASIQVYNMFPWLFKWLP-TRKEINETFEMNRNQNFSLFHQLRETL-------NPEMCRGVVDAFMVRRQNLE-----------------------------------------KSGVKNNHFHDDNLFMTVTNLFVAGTETTSTTLRWGLLLMAKYPNIQDQVQEELRRVIG-DRQ------------------------------------------------------VQVSDRKNMPFTDAVIHETQ-RLGNIVPAALPHKTSKDFSFHGYFIKK------DTTVYPLLTSVLNDPAEWEKPHTFHPA------HFLDKDG---------NFVKRDAFMPFSAG-----------RRICLGE-SLARMELFIFFTTLLQHFTFTPAPGISRDELDLTPVGT--FTLNPS--------PHKLCAVSRM------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP2K50 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGILKAFLRSFS--PTSFLGDVAFLLLIYVCFSFIFSSKTYRH-----------------------------GPPGPKPLPLLGNLLQLDF----------------KRLDRTFVEFS------KKYGSVFAIYLGQRKVVILAGYQTVKEAFVNYA---EEFGDRDVPIVAK-DTNLDHG---IAWVNGDSWKEMRRFALTNLKDFGMGKKA-------CEDKIIEEFHKLIKEFK-------------KFKGEAFDMAQLMNFAVCNIICSMVYGNRFEYGDPEF----QTVINKTGESLNLLGT---PAIKLYTLFPSLGKLLFSARKKLKTTFEDNKRHHLTLLNRLRETL-------NPQMFRGVADVFIAPDLHLQ-----------------------------------------ESEISTSNYTDENLLAIVINLFAAGTETTLTTLRWGLLFLTKHPKIQAKVQEELNTVVG-SRQ------------------------------------------------------VQVQDKQNLPFTNAVIHEIQ-RLANIVPLALAHSTSKDVIFQGHFIEK------GTIVFPLLTTVLHDESEWEKPYDFHPA------HFLDKDG---------NFTKRDAFLPFSAG-----------RRICPGE-SLAKMELFIFFTTFLQHFRFTPPPGVSEEDLDLTALPG--GTLRPQ--------PHKLCAVSLK------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP2K51 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFED-LQSP--TSVLFG-VFVALLLRHLFYS-NF-SSNERQ-----------------------------EPPGPRPVPLFGNLFQVDL----------------KRLHQSLFNLS------KKYGPVFQVYFGPRKVVVLAGYRMIKQALVNQA---DEFGTRKMIPAFY-DLSKGHG---IVFSNGETWKEMRRFALTTLRDFGMGKKM-------SEKIIIEECGFLIKEFE-------------QFEGKVFNNTKSINYATTNVISALMFGKRFEYKDQVF----QGMVERGNEIIHLVGT---ASLWIYNIFPWLGPFLK-NWRDFMKILEDNEKTVNKIIADLKETL-------DTEVCRCFVDAFLIRQKHLE-----------------------------------------DSEITNLHYHDENLLYSVTNLLEAGNDTTANTLKWGLLYMAKFPHIQDRVQEELSRVVG-TRQ------------------------------------------------------IQTEDRKNLPYTDAVIHETQ-RLANILPISLLHATSKDITLQGYFIKE------GTAVLPLLTSVLYDESEWESPHSFNPS------HFLDDEG---------KFIRRDAFMPFSAG-----------RRACLGE-SLARMELFLFFTSLLQRFRFTPPPGVSGDEVDLTPVVG--FTLSPR--------PQKLCAVQRK------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP2K52 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLEDIFQSP--TSVSLFGVFVALLLLHLLHS-TF-SSQKRP-----------------------------EPPGPRPLPVFGNLFQVDL----------------KRLDQSLFNLS------KTYGPVFQVYFGPKKVVVLAGYRTVKEALLNQA---DEFGNREITPIFY-DFSEGHG---IVFSNGDSWKEMRRFALSTLKDFGMGRKM-------SEEIIIEECGYLIKEME-------------QYGGESFNNTQAISYTASNVISALMFAKRFEYKDPVF----QSMVEKDKQNIHLAGS---ASIMIYNFIPWLGPLLK-NRRTMLKNFIDGRADIWRKIEELKETL-------DPEVCRCLVDAFLIRKKQLE-----------------------------------------DSKIKNSHYHDNNLLYSIQGLFVAGTDTTATTLKWGLLYLTKFPHIQDRIQEKLSRVVG-SCQ------------------------------------------------------VRIEDRKNLPYTDAVIHETQ-RFANIGPLALPHTTTKDVTLQGYFIKK------GTTVLTVLTSVLYDENEWESPHSFNPS------HFLDDEG---------KFIRRDAFMPFSAG-----------TLLDLGI-SL-------------------------------------------------------------------------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2N22 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWLRDLNLWLNLRGILLFIFVLLLVCLFNK--KDPPS-----------------------------FPPGPLALPILGNIFNIES----------------KQPHIYLTKLA------DVYGNVFCIRLGRHKTVFVSGWRMVKEALVTKA---ENFVDRPYSPMVTRIYSGNSA--GLFFSNGKVWRRQRRFAMATLRTFCVAKSS-------IEESVCEESQHLQQAME-------------TEEGEAFDPIPFLNSAVSNIICQIVFGRRFDYSDHDF----QSMLKNLTDMAYLEGS---IWALLYDAFPALMRHLPGPHNGIFSSSKCLKASIRKEIKRHKLDL-------DPSNPRDYIDKFLIQERHNR-----------------------------------------KTDV---GFEEDNLVLCCLDLFLAGSETTSKTLQWGLIFLIINPHIQEKVRAEINSVIGLTRP------------------------------------------------------PSMADKPNMPYTDAVIHEIQ-RMGNIVPLNGLRMAAKDTTLGGYIIPK------GTSVMPNLTSVLFDKNEWETPGTFNPE------HFLDEEG---------KFKRREAFLPFSAG-----------KRMCLGE-SLAKIELFLFFVGLCQKFHFSTLDGVELSAEGI---TG--ATRSPY--------PFKIIAKP-------------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2N23 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWLYNFLLSIDLKSLFLFIFLFLLIADFLK-NRKPPN-----------------------------FPPGPRPFPFVGNIVGLDS----------------KQPQNYFAKLA------KAYGNVFTVRFGRDTTVIVWGYKMVKEAIVTQA---ENFVDRPYNALADRIYSQQEA--GVFMSNGEKWRRQRRFALSTLRTFGLGKST-------LEQSICEEVRYLQEELE-------------REKGKPFTPTGLFNNAVSNIICHLVMGKRFDYSDHSY----QIMLKYMSEAVCLEGS---IWGQLYLAFPKVMEHLPGPHNRIFSNYNSILAFLNQEIEKHKKDL-------DPNNPRDYIDTFLIEMKNHK-----------------------------------------DSDL---GFTETNLMMCSLDLFLAGTETTATTLMWALIYLIKNPDIQEKVQAEIDNVIGQNRQ------------------------------------------------------PSMADRPNLPYTDAVVHEIQ-RFGNIVPLNGLRVAAKDTNLGGYFIPM------GTSIMPILTSVLFDKTEWETPDTFNPG------HFLDANG---------KFVKRDAFLPFSAG-----------KRVCLGE-GLAKMELFLFLVGLLQKFTFSVPEGVELDTEGI---TG--FTRVPL--------PYKVYAKVR------------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2P16 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEAFYSVLGLEWLDTRSILIFIFVFLLLSDILK-NRKPKN-----------------------------FPPGPRSLPFIGDLHRINP----------------SRLHLQLVEFA------EKYGDVFSLHFFGERAVVVNGYKNVKEALVQQG---EDFIDRPAIPLFSEFFIN-KG---LVMSNGYPWKVQRRFALHTLRNFGLGKKN-------LALYIQQECQYLTEAFA-------------EQQGKPFNAQLLIHNAVSNIICCLVFGSRFEYSDKQY----QTILHYFNQIIQLQGA---FSVQIYNAMPSLMTWIPGPHKKIFRLIQKLMDFVEIRIKEHRENL-------DPSSPRDYIDAFLIEMGEVK-----------------------------------------DK-DS--GFDLNNLCACTLDLFGAGTETTTTTLHWGLLYMIYYPHIQERVQAEIDAVIGPSRQ------------------------------------------------------PSISDREDMPYTDAVIHEIQ-RMGNIIPLNLPRIANKDTNLDKYSIPK------GTIIIPLLHSVLHDETMWETPHTFNPQ------HFLDKDG---------KFRKREAFMPFSAG-----------KRVCLGE-QLARMELFLFFTSFLQRFKFSSPAGEQPSLDFK---MG--GTRLPK--------PYHLCAVPR------------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2P17 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEAISAVLGLEWLDSRSVLIFLCVFLLLTDVLK-NRVPRN-----------------------------FPPGPRSLPFIGHLHRISA----------------SKIHLQFKEFA------EEYGNIFSLRLFGGRVVVVNGYKLVKKALVQQG---EDFVDRPNVPVFNELIKN-QG---LVGSNGYPWKQQRRFALHTLRNFGLGRKS-------LERYIQQECQYLTEAFA-------------DHKGQPFNAQKLINNAVSNIICCLVFGSRFEYTDKQY----HKILKDFNEIMYLEGS---VWAQFYNTAPWLMRWLPGPHQKIFTLTQSIIDFIEIRIKEHRENL-------NPSSPRDYIDSFLIEMQKHE-----------------------------------------DK-ES--SFDLRNLCFCTLDLFGAGTETTTTTLNWGLLYMIYYPHIQERVQAEIDAVIGPSRQ------------------------------------------------------PSVADRENMPYTDAVIHEIQ-RMGNILPLNVVHMANKNTTLDKYSIPK------GTMILATLDSVLRDETMWETPHTFNPQ------HFLDKDG---------KFRKREAFMPFSAG-----------KRVCLGE-QLARMELFLFFTSFLQRFKFSAPAGEQPSLDFK---LG--VTRCPK--------PYCLCAVPR------------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2P18 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEAISAVLGLEWLDSRSVLIFLCVFLLLTDVLK-NRVPRN-----------------------------FPPGPRSLPFIGHLHRISA----------------SKIHLQFKELS------EKYGNVFSLRLFGGRVVVVNGYKLVKEALVQQG---EDFMDRPQVPLFEELVGN-NG---LVGSNGYPWKQQRRFALHTLRNFGLGRKS-------LERYIQQECQYLTEAFA-------------DHKGQPFNTQKLINTAVSNIICCLVFGSRFEYTDKQY----HKILQSLNEALYLEGS---VWAQMFNALPWLMKWLPGPHQKIFTLNQELQEFTKIRIKEHRENL-------DPSSPRDYIDAFLVEMEKNR-----------------------------------------DE-DS--GFNLNNLCFCVVDLFVAGTETTTTTLIWALLYMIHHPHVQGRVQAEIDAVIGPSRQ------------------------------------------------------PSLSDRENMPYTNAVIHETQ-RMGNILPLSLGHMANRDTTFENYTIPK------GTIIITTLDSVLHDESMWETPHAFNPQ------NFLNKDG---------TFRKREAFMPFSAG-----------KRVCLGE-QLARMELFLFFTSLLQRFKFSSPAGEQPSLDFK---LG--ITRCPQ--------PFRLCAVPR------------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2P19 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGSVIDVLGLDWIDGRSILLFLFGFLLLSDVLK-NRAPRN-----------------------------FPPGPWALPFIGDLHRIQP----------------SRLHLQLVQFT------EKYGKVFSLRLFGGRVVVVNGYKLVKEALVQQG---EDYTDRPVIPMFQEIAGN-KG---LLLSNGYPWRQQRRFALQTLRNFGLGKKS-------LELSIQQECQYLTDVFA-------------DQQGHPLNALTLINNTVSNIICCLVFGNRFEYTDEQY----HEILHKFNEIVYLEGS---AWAQIYNVLPWLMRWLPGPHQKLFSLFRDVIDFIEIRIKEHRENL-------DPSSPRDYIDSFLIEMSENQ-----------------------------------------DK-ES--GFNLKNLCFCVLDLFGAGTETTTTTLHWGLLYMIYYPHIQERVQAEIDAVIGPSRQ------------------------------------------------------PSISDREDMLYTDAVIHEIQ-RMGNILPFNVAHMANKDTNLDKYSIPK------GTIVLPMLHSVLHDESIWETPHSFNPQ------HFLEPDG---------KFRRREAFIPFSVG-----------KRVCLGE-QLARMELFLFFTSLLQRFKFSSPAGEQPSLDFK---LG--ASHCPK--------PYRLCAVPR------------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2P20 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKTLLDVLGLDWIDVRSFLFFLFIFLLLSDVLK-NRAPRN-----------------------------FPPGPWALPFIGDLHRIQP----------------SRLHLQLTEFA------EKYGKVFSLRLFGGRVVVVNGYKLVKEALVQQG---EDYTDRPVIPMIQEIFGN-TGGVCISVTNGYQWRQQRRFALQTLRNLGLGNKT-------LEQSTQQECQFLTEAFA-------------DQQGQPFKALTLINNAVSNVISCLVFGNRFEYTDKQY----QTILQDLSDLVYLEGS---VWAKFYNTAPWLMKWLPGPHQKIFSVAQEITDFIEIRIKEHKQNL-------DPSSPKDYIDSFLVEMAKNQ-----------------------------------------DK-DS--GFNLNNLCFCVLELFGAGTEPNATTLHWGLLYMIHYPHIQERVQAEIDAVIGPSRQ------------------------------------------------------SSLSDREDMPYTDAVIHEIQ-RMGDVVPLNLPHMTNNDTILDKYTIPK------GTMVMPLLHSVLHDESIWETPHSFNPQ------HFLDPDG---------KFRRREAFIPFSVG-----------NRVCFGE-QLARMELFLFFTSLLQRFKFSSPAGEQPSLDFK---LG--ATRCPK--------PYRLCAVPR------------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2R1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVSLK-SRSLMPVSGAEAVLAVACLAAALLAFLLVRQLVKQRRPPG-----------------------------FPPGPSPIPVIGNIFSLAT----------------EP-HVFLKKQS------EVHGRIFSLDLGGIMTVVLNGYDCIKECLYHQS---EMFADRPSLPLFK-KMTKMGG--LLNCKYGKGWIEHRKLACNSFRYYGSSQRL-------FERRITEECMFFVDAID-------------KYKGKPFNPKHLVTNAVSNITNLIIFGQRFTYDDRNF----QHMIELFSENVELAVS---GWALLYNAFPWIEYLPFGKHQKLFRNAAEVYNFLQEVINTYSQGR-------VKHEPRHYIDAYLDELEQST-----------------------------------------GNPNS--SFSYENLIYSVGELIIAGTETTTNTLRWAALYMAMYPNIQERVHREIDSVLSNGRP------------------------------------------------------PSMEDKHRMPYVEAVLHEVL-RFCNIVPLGIFRATSQDATVNGYTIPK------GTMVITNLYSVHFDEKYWNDPSVFSPE------RFLDSSG---------NFVRREAFLPFSLG-----------RRHCVGE-QLARMEMFLFFTTLLQRFHLQFPPGTVPTVTPK---LG--MTLQPK--------PYSICAVRRQQKLSCAGDTPYHK----------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2U1 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDTLSWLGHVTLSPSHVVPLAVFLLAFYLAAFYRRRAGAYTN----------------------------IPPGPKPWPVVGNFGGFLVPPALRGRFGQRRD--HVSVMEALTSQA------DLYGNIYSLFVGSQLAVVLNGYEVVRDALSNHP---DVFSDRPDVPSIS-ILTKRRG--IVFAPYGPVWRKQRKFCHTTLRSFGLGKLS-------LEPCIQRGLVTIKAELLRLNG---------ESGGTGVDPAPLISNAVSNVVCSLILGQRFHHGDPEF----RAILGLMARGLEICIN---SAAILINVCSLLYYLPFGVFKELRQVERDITVFLKRIIANHRETL-------DPENPRDLADMYLIEMLARRA----------------------------------------AGE-EDSSFTEDYLFYIIGDLFIAGTDTTTNSVLWTLLYMALYPDVQDKVQAEIDKVVGRRRL------------------------------------------------------PSVTDRGSLPFTEATIMEVQ-RLAVVVPLSVPHMASETTEFRGYTIPK------GTVIFPNLYSVHRDPAVWDEPDSFNPT------RFLDDEG---------KLLKKEFFIPFGIG-----------RRVCMGE-QLAKMELFLTVTGLLQSFRFRLPDGTPPPSLQGR--FG--LTMAPC--------PFRVCVNDRSEDRGTHVI---------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2X24 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFVSIVLLWLCLWFIILQLKARRPKN-----------------------------FPPGPPTLPVLGNLLNLNL----------------ENPLQDFERLR------KSYGNVYSLFIGPKPAVIINGLKVMKEAMVIKA---TDFAGRPQDLFIN-DITQRKG--VILADYGENWKEHRRFALMTLRNFGLGKQS-------MEDRIHDEICYTVKTLE-------------KNVGETFSPQVMFHNAGSNIICQILFGKRYEYDDDII----KVIVQCFTENARLGNG---LWAMLYDSLP-PIRYLPLPFKKAFKNAEICENLIFNLVEEFKKTR-------VPGEPRHFVDCYLDELDKRS-----------------------------------------GEDSS---FSEDRLPLYSLDLHFAGTDTTSNTLLTAFLYLMNFPHVQERCQQEIDQVLDGKDR------------------------------------------------------VSFEDRHNMPYVQAVIHEVL-RVANTVPLSVFHCTTKDTELMEYTIPR------GTMIIQNLMSVLREEGQWKFPHEFNPE------NFLNEQG---------DFVKPEAFMPFSAG-----------PRMCLGE-GLARMELFLITVTLLRKFRFVWPEDAGEPDFSP--AYG--ITLCPK--------PYNMK----VELR--------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2X25 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFISIVLLWFCLGFILLQLKPRRPKN-----------------------------FPPGPPTLPVLGNLRYLTS----------------KNPLKDLEKLR------QSYGDVYSLFLGSKPAVLISGLKAMKEAMVVKA---TDFAGRPQDLLIG-DLTQRKG--VILVDYGSLWRDHRRFALMTLRNFGLGKKS-------MEERIHEEIQFTVKTLE-------------KSVGKTLSPQVMFHNAASNIICKVLFGTRYEYDDETL----RVIVRCFTEVNRIANG---PWAMLYDSVP-SVRRLPLPFNKAFKNMEVLLSLSARFVSEHKKSR-------IPGKPRDFVDCYLDELDK-N-----------------------------------------KEDSS---FSEDQLRSMNFDLYLAGTDTTSTTLLTGFLYLMNFPHIQERCQQEIDVVLEGKDR------------------------------------------------------ATFEDRHSMPYMQAVIHEMQ-RVANILPLSSYHCTTKDTELMGYSIPR------GTMIIQNLTSVLKEEGQWKFPHEFNPE------NFLNEQG---------DFVKPEAFMPFSAG-----------PRICPGE-GLARMELFLITVTLLRKFRFLWPEDAGEPDFTP--IFG--ATLSPK--------PYNMK----VQLRS-------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2X26 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFILIVLLWFCLGFILLQLKPRRPKN-----------------------------FPPGPPTLPVLGNLRYLTS----------------KNPLKDLEKLR------QSYGDVYSLFLGSKPAVLISGLKAMKEAMVVKA---TDFAGRPQKLFVN-DVTRHKG--VILVDYGSLWRDHRRFALMTLRNFGLGKKS-------MEERIHEEIQFTVKTLE-------------KSVGKTLSPQVMFHNAASNIICKVLFGTRYEYDDETL----KMIVQCFTELTTLANG---PWAMVYDSVP-FVSYLPLPFKKAFRNMEMFMEFSIRVVKEHKKSR-------VPGEPRDFVDCYLDELDKQD-----------------------------------------KQDST---FSEDQLKSMNFDLYIAGTDTTSNTLLVGFLYLLNFPHVQERCQQEIDTVLEGRDQ------------------------------------------------------VTFEDRHNMPYVQAVIHEMQ-RVANILPLSVFHCTTKDTELMGYSIPR------GTIMIQNLTSVLKEEGQWKFPHEFNPE------NFLNEQG---------DFVKPEAFMPFSAG-----------PRMCLGE-GLARMELFLITVTLLRKFRFIWPEDAGEPDFNL--VFG--AILTPK--------PYNMKGRAEVQAVKQ------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2X27 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFVSVLLLSLCLLFIIFQLKPRRPKN-----------------------------FPPGPFTLPVLGNLLHLD------------------NPLENLEKLR------KSYGNVFSLFIGPRPTVVINGLKAMKEAIVVKA---ADFSGRPQDLLVN-VVSQRKG--VVLADYGPSWREHRRFALMTLRNFGLGKKS-------MEDRIHDELQYTIKILE-------------NSIGSTLSPRVMFHNTASNIICQVLFGKRYEYDDDVI----KTIIWSFNELAKMANG---LWALVYDSFP-LCRNLPLPFRRAFKIYGSCQDIAMRLIDEHKKSR-------VPNEPRDFLDCYLDELDKRG-----------------------------------------DDGSS---FSEERLSNYILDLRFAGTDTTSNTLLTGFLYLIHHPHVQERCQQEIDRVLQGKDR------------------------------------------------------VSYEDRNDMPYVQAVTHEMQ-RVANTAPLSVFHSTTKDTELMGYSIPK------GTMIIQNLTSVLKEEGQWKFPHEFNPE------NFLNEQG---------DFVKPEAFMPFSAG-----------PRMCLGE-GLARMELFLITVTLLRKFRFLWPEDAGEPDYTP--IFG--ATLSPK--------PYNMK----VQLRS-------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2Y9 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEFSSTLILLGLISALIWFLRAKTS---RKAR-----------------------------LPPGPSALPLIGNLLQINK----------------EAPFKSFVELS------RTYGPVMTLQLGWQRSVVLAGYDAVKEALVDQA---EDFTGRAPVPFLH-RATKGFG---LGISNGERWRQLRRFTLTTLRDFGMGRKG-------MEEWIQEESKYLRECIH-------------SYKGKPFDPTVLLSRTVSNVICCLVFGQRFSYEDKQF----VELMATISEIARFNSS---PLGVMFNLFPWLMERLPGKHQVVFGKIERVREFVMKKIQEHKETL-------DLSSPRDYIDCFLIRAEQEK-----------------------------------------N--NPSTEFHYENLVGTVMNLFVAGTETTSSTIRYALSVLIKYQEIQDKMQEEIDTVIGKNRC------------------------------------------------------PSMEDRKSLPFSDAVIHEVQ-RLLDIVPFSIPHYALQDISFRGYTIPK------GTLIFPLLHSVLKDETQWVNPISFDPQ------HFLDQNG---------NFKKNPAFLPFSAG-----------KRACVGE-SLARMELFVFIVGILQDFIVSCPEGP--DSINLVPEFSS-FANLPR--------CYNIIATPR------------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2Z6 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MESFFATIGSYVEWDIKSLLLFLVVFIITADYIKNR-RPVG-----------------------------YPPGPRAYPIVGNIFTLNP----------------NRTYESLMELA------KTYGDVYSLRFGQNKTVVLNGFEAVKEGLATKG---DSTIDRPIFPLQDEICGG-LG---VIFSNGNIWKQQRRFALSTLKYFGFGKKS-------LEPVILEEFTHCAEEIK-------------RYKGKPFNPHLVINYAVSNIICHLVFGHRFDYGDEKF----TKLMLLFDKCLQIEAS---IWSQLYNSFTLLMRCLPGPHQNLKQHWNIVKNFIREEMEEHKKKW-------DPFERRDYIDCYLNEIQMNQ-----------------------------------------GQDDN--TFDEENLIMCVLDLFVAGSETTSTTLRWAFLYMAKYPEIQEKVQAEIDSVIGQSRQ------------------------------------------------------PSMEDRANLPYTDAVIHEIQ-RIGNIVPLSLPHSTNREIQLGGYTIPK------GVLIIPNLASVLFDKNEWETPFTFNPG------HFLNKEG---------KFVKRAAFIPFSAG-----------KRLCLGE-NLARMELFLFFTSFMQHFTFSMPAGVQVVLDYR---AG--VTLAPK--------PFEICITSRQDHL--------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP2Z6.like ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MESFFATIGSYVEWDIKSLLLFLVVFIITADYIKNR-RPVG-----------------------------YPPGPRAYPIVGNIFTLNP----------------NRTYESLME---------TYGDVYSLRFGQNKTVVLNGFEAVKEGLATKG---DSTIDRPIFPLQDEICGG-LG---VIFSNGNIWKQQRRFALSTLKYFGFGKKS-------LEPVILEEFTHCAEEIK-------------RYKGKPFNPHLVINYAVSNIICHLVFGHRFDYGDEKF----TKLMLLFDKCLQIEAS---IWSQLYNSFTLLMRCLPGPHQNLKQHWNIVKNFIREEMEEHKKKW-------DPFERRDYIDCYLNEIQM-------------------------------------------GQDDN--TFDEENLIMCVLDLFVAGSETTSTTLRWAFLYMAKYPEIQEKVQAEIDSVIGQSRQ------------------------------------------------------PSMEDRANLPYTDAVIHEIQ-RIGNIVPLSLPHSTNREIQLGGYTIPK------GVLIIPNLASVLFDKNEWETPFTFNPG------HFLNKEG---------KFVKRAAFIPFSAG-----------KRLCLGE-NLARMELFLFFTSFMQHFTFSMPAGVQVVLDYR---AG--VTLAPK--------PFEICITSRQDHL--------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP3A176 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGDF-YFSAETWTLLVAFVTLLLLYGYWPYGTFKKL----------------------------GISGPKP-LPFFGTLLHYRKG------------------FFNFDEEC-----YKKYGKIWGIYDGRQPVLCIADPAMIKTVLIKEC-----YSLFTNRR--NFRLNGPLYDAVSIAE-DDQWRRIRSVLSPSFTSGRLKEMFA------IMKRHSTNLVSSIKKKSITLALWY--------SNISVCTYRFFGPYSMDIVTSTAFSVDIDSLHNPS----DPFVTNIKKMLKFDLLSPL-FLAVAFFPFVGPIMEKLEFSFFPKSVTDFFYASLKKIKSNRE-------KSRLQGRVDFLQLMIDSQKNNNL------------------------------------SEG---QE-DKGLNDHEILSQSMIFLFAGYETTSSSLTFLAFNLATNPEVMKKLQEEIDATFPNKA------------------------------------------------------PVEYAALMEMEYLDCVINESL-RLFPIASRLERVAKATVDIN-GLVIPK------NMVVLIPTWPLHRDPELWPEPEKFKPE------RFSKANK---------DKIDPYVYMPFGAGP-----------RNCIGM-RFALVMMKLAVVEVLQRYSFSVCKETEIP-----IELDIQGLLMP-------KRPIKLKLVPRSESSS-------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP3A177 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGDF-YFSAETWTLLVAFVTLLLLYGYWPYGTFKKL----------------------------GISGPKP-LPFFGTLLHYRKG------------------FFNFDEEC-----YKKYGKIWGIYDGRQPVLCIADPAMIKTVLIKEC-----YSLFTNRR--NFRLNGPLYDAVSIAE-DDQWRRIRSVLSPSFTSGRLKEMFA------IMKRHSTNLVSSIKKKSITLALWY--------SNISVCTYRFFGPYSMDIVTSTAFSVDIDSLHNPS----DPFVTNIKKMLKFDLLSPL-FLAVAFFPFVGPIMEKLEFSFFPKSVTDFFYASLKKIKSNRE-------KSRLQGRVDFLQLMIDSQKNNNL------------------------------------SEG---QE-DKGLNDHEILSQSMIFLFAGYETTSSSLTFLAFNLATNPEVMKKLQEEIDATFPNKA------------------------------------------------------PVEYAALMEMEYLDCVINESL-RLFPIASRLERVAKATVDIN-GLVIPK------NMVVLIPTWPLHRDPELWPEPEKFKPE------RFSKANK---------DKIDPYVYMPFGAGP-----------RNCIGM-RFALVMMKLAVVEVLQRYSFSVCKETEVR-----AQFSTFTQTYRSFGASPVQTPVMGDDFERYITS--------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP3B10 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFSAATWTLLALFFTLLLLYGLWPYRFFRKL----------------------------SISGPRP-LPFIGTMLGVRKG------------------IFSFDREC-----QTKYGDVWGLYEGRNPMLIIADPELIKIVLVKEC-----YSAFTNRR-DVIGMGGPLEDAITAVK-DERWKRIRSTISPCFTSGRLKQVFP------FIARFADRLVEKLGKKNL---------------DEPIDIKQFMAPFSLDVVTSASFSVEIDSINNPD----DPVNAHMQKMMKINFWP---FLVLMVFPFGRHLLKLFKIEMLPRPSVDFFYNIIKKFKDQHQA--------AESTRGDFLQVMIQNEIPEADI-----------------------------------KNE--QEQPSKGLTEHEILSQALMFIFAGYETTSTTLSLIFYNLATNPDVMQTLQDEIDASLQKDT------------------------------------------------------SISYTDLSNLQYLDQVILESM-RLISTAPRLERVCKKTVQIN-RLTVPE------GTLIGIPVQLLHKDPRFWSSPELFKPE------RFSKENE---------AELNPYAYMPFGLGP-----------RNCVGM-RYAILVMKMVIVRLLQSYTLETCKDTMIP-----LEFNWK--FQP-------TKPIKLKFAPRIS----------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP4F128 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVLHSVLCQVFSWTGLCLFLRWVGTGLAAVAAAWTTRLLVRHAWYTHRLS----------------------------CFDKPETRSWLLGHLGQMQST------------EEGLQRVDDLVQTY-----KHS---CCWFLGPFYHLVRIFHPDYVKPLLMASGN-ITVKDELIYGHLRP-----WLGKSLLISN-GEEWSHRRRLLTPAFHFDILKNYVT------TFNSSTNTMHNKWSRLVAEG-------------TTNLEMFNHVTLMTLDSLLKCAFSYSSNCQEST--NEYVAAIVELSDLVIDRRFRILHHWDWIYWKTQQGKRFKRALSVVHRFTREVVQKRRALISQQRETETQTTLTTTPQKKK--DFVDVILLSKDDDE---------------------------------------------QGLSDEEIQAEANTFMFAGHDTTASAICWTLYNLARHSHHQEKCRQEVMELMEGRERH----------------------------------------------------AIEWEDLSNLPFTTMCIRESL-RLHSPVQAVTRRYTQDMTLPGGLSVPE------GVICLVSLYGTHHNPAVWANPHEFDPL------RFDPANT---------RSHSSHAFIPFSSGP-----------RNCIGQ-KFAMAELRVVVALTLLRFRLTLGVDPKSGSGSKGVRRLPQLVLRAE-------GGLWLQLEPLNPKPVDK------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP4T17 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MELTEAFLQLQPRW---HYLFS---ALCLVVLVYKFSVFLVKRKAVLRSTE----------------------------AFPGPPG-NFLLGHVLEFKQD------------GTDLFRTVKWARTY-----PYG---FPMWFGPFLCLLSVHHPDYVKTILTSSE----PKDEFVYSFLMP-----WIGDGLLVSK-GQKWFRHRRLLTPGFHYDVLKPYVQ------LMSQSAKTMLDKWESYAKT--------------NENFELFEHVSLMTLDTILQCAFSCKSNCQTEGGTNAYIKAVYELSNIVNFRLRTFPYHSDLIFHLSPHGFKFRKACKVAHSHTEEVIRKRKEALKEETE-------LGRIQAKRYLDFLDILLVARDENQ---------------------------------------------QGLSNEDIRAEVDTFMFEGHDTTASGISFLLYCLACNPEHQKICREEILQVLDGKD------------------------------------------------------TMEWEDLNKIPYTTMCIKEAL-RLYPPVPGMSRKLTKPVTFFDGRTLPA------GFRVGVSVFSVHRNPAVWENPDVFDPL------RFLPENV---------TKRSPHAFVPFSAGP-----------RNCIGQ-NFAMNELKVVAAMTLKRYQLIEDPDFK-------PKMVPRLILRSL-------NGVHIKIKPVEPQV--------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP4T18 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MELTEAFLQLQPRW---HYLFS---ALCLVVLVYKFSVFLVKRKAVLRSTE----------------------------AFPGPPG-NFLLGHVLEFKQD------------GTDLFRTVKWARTY-----PYG---FPMWFGPFLCLLSVHHPDYVKTILTSSG----ICFALIC-LICPTL---FLGDGLLVSK-GQKWFRHRRLLTPGFHYDVLKPYVQ------LMSQSAKTMLDKWESYAKT--------------NENFELFEHVSLMTLDTILQCAFSCKSNCQTEGGTNAYIKAVYELSNIVNFRLRTFPYHSDLIFHLSPHGFKFRKACKVAHSHTEEVIRKRKEALKEETE-------LGRIQAKRYLDFLDILLVARDENQ---------------------------------------------QGLSNEDIRAEVDTFMFEGHDTTASGISFLLYCLACNPEHQKICREEILQVLDGKD------------------------------------------------------TMEWEDLNKIPYTTMCIKEAL-RLYPPVPGMSRKLTKPVTFFDGRTLPA------GQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP4V2 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALVMGSYSFLFLGVSILVAALTYITYKMLSGYLHKWFMMK----------------------------PIPGVDGTHLFIGDALMFKPNA-----------GEFFRQIVDYTTSF-----RDVP-LFKLWVG-MIPFVVLFHAETVEKVLSSPV---HLDKSFAYKFLHS-----WLGTGLLTST-GQKWRQRRKILTPTFHFSILTDFLH------VMNEQAEVLVEKLEKKAGQ---------------GPFNCFSDITLCALDIICETAMGKKIYAQSDSE-SEYVKSVYRMSDIISHRQRKPWFWPDFIYYWFGQGKEHDRTLKILHSFTQRVIHEKSENMSSSDPDSD-----SDRDPKKRQAFLDMLLKTTDEDG---------------------------------------------NRLSHQDIQEEVDTFMFEGHDTTAAAMNWTLHLLGSHPEVQWKVHQELQEVFGTSGR-----------------------------------------------------PITTEDLKQLKYLDCVIKESL-RLFPSVPYFARSLCADCHIN-GFKIPK------GANAIVITYALHRDPRYFPEPEEFRPE------RFFPQNS---------VGRPPYAYIPFSAGL-----------RNCIGQ-RFAQMEEKVVLANILRNFSVEACQKREE------LCPVGELILRPK-------QGIRIKLERRRFTMTASHRLSSLNHNEVTRLRCEEQDNTKK------------------------------------------ Kryptolebias_marmoratus_Km.CYP5A1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMESGDFLNLFNIEISRTSLTLSLILIFLSLFYWYSVYPFSVLSGF----------------------------RIRHPKP-VPFFGNLFMFREG------------------FFKPLTDI-----INTHGRVCGYYLGRRPIVVIADPDMLRQIMVKD------FSSFPNRMKFNFVTKPM-SDCLLMLR-DEKWKRVRSILTPSFSAYKMKEMVP------LINTATDALMNNLNIHAE--------------SGDAFDIHKCFGCFTMDVIASVAFGTQVDSQNNPD----DPFVRHAQMFFSFSFFRPLLLFF-IAFPTIMAPIARYIPNKRRDLMSGFFINIIQKIIKQRED------RPPDQRRRDFLQLMLDARNSQESVSLEHFDTANHSDEIDNQSQQTQPSTLDQEGNRPHPDESPVRHPQKKVMTEDEIVGQAFIFLVAGYETSSNTLGFTCYLLAINPECQRKVQEEVDDYFTRHD------------------------------------------------------SPDYTNIQELKYLDMVVCEAL-RLYPPGFRFAREVANDCVVN-GQFLPK------GVSLEIPVGFLHYDPEYWPEPEKFIPE------RFTPEAK---------ANRHPFVYLPFGAGP-----------RNCVGM-RLAQLEIRMALTHLFHRFSVVACSETKVP-----LDLKSSSTLGP-------KNGVFVKITRRERLEGHKVSPSDNNLK--------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP5A2 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------METVGDFLNVFSFEASRTKVTLSLFVIFLALLYWYSVYPFSVLSRC----------------------------GIKHPKP-VPFFGNMLMFRKG------------------FFQPLSDI-----IKTHGRVSGYYFGRKPVVLVADPDMLRQVLVKD------FSSFPNR-LVRFSNQSLQEDCLLILR-NERWKRVRSVVTPTFSAAKLKDMVP------LINTATDALMNNLSVHAD--------------SGKAFDIHKSFGHFTLDVIASVTFATQVDSQNNPD----SPFVRIAQMFISLSFFRPLTLFFTVLFPGILAPFARFVPNKKREQMDKIFISSFQALIKQREE------QPPDQRRRDFLQLMLDARSGQEAVSLEHFDTGNHSDELNSKSQQKQPSALNQDKNHSHSKDSLMNRPQKKTITEDEIVGQAFVFILAGYETSRSTLSFTCYLLALHPECQGKVQKEVDDLFTRHD------------------------------------------------------SPDYANIQELKYLDMVVCESL-RLYPPGFRFAREVEHDCVVN-GHFLPK------GANLEVPAGFLHHDPEYWPEPEKFIPE------RFTPEEK---------ANRHPFVYMPFGAGP-----------RNCVGM-RLAQLEIRMALAHFFHRFSVTTCSETKVP-----LELKSFGTLGP-------KNGVTVKITRRDK----------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP5A3 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------METVGDFLNVFSFEASRTKVTLSLFVIFLALLYWYSVYPFSVLSRF----------------------------GIKHPKP-VPFFGNILMFRKG------------------FLKPVSDI-----IKTHGRVCGYYFGRRPRVLVTDPDMLRQVLVKD------FTYFPNR-LVRFSTKPL-EDSLLFLT-NERWKRVRSVITPTFSTAKLKEMVP------LINTANNALMNNLSVHAE--------------SEKAFDIHECFHYFTMDVIASVAFGTQLDSLNNPD----HPLVRHVQMFFASSFFRPLLLLY-ILFPSIMAPFARLIPKIKQAYLDKFFISSIKTIIKQREE------QPPDQRRRDFLQLMLDARTGQEAVSLEHFDTGNHSDELNYKSQKKQPSALNQENSHSPTEDSIMRHPQKKMMTEDEIVGQALLFFLAGYDTTSNALSFTCYLLALHPECQRKVQEEVDDFFTRHD------------------------------------------------------SPDYTNIQELKYLDMVLSETL-RLYPPGFRFVREVEHDCVVN-GQFLPK------GVTLEVPAGFLHHDPEFWPEPEKFIPE------RFTPEAK---------AKRHPFVYLPFGAGP-----------RNCVGM-RLAQLEIRMALAHLFSRFNIVSCSETKVP-----LDLKSFGTLGP-------KNGVFLKITKRNK----------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP5A4 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLMFREG------------------FLKPLSEI-----VKTHGKVCGYYLGRKPMVVIADPDILRQVMVKD------FNNFTNR-RFQLTTKPW-KDCLLMLR-NEQWKRVRSVVTPTFSAAKLKEMVP------LINTATDALMNNLSVHAE--------------SGKVFDIHKCFQCFTMDVIASVAFGTNLDSQNNPD----DPFVHYAQMFFAMSFFKPLVLFS-ILFSKIMAPLVRIIPNKRREEIDKFFISSIKKIIKQREE------QPPDQRRRDFLQLILDARTGQESVSLEHFDTTKHSDELDNRSQQTPLPVSDQKISHPHIQKSSTGHLQKKTITEDEIVGQAFVFFLAGYETTSSTLGFACYLLALHPECQSKVQEEVDDFFTRHD------------------------------------------------------FVDYTNVQELKYLDMAVCEAL-RIYPPGFRFNREVYHDCVIN-GQFFPK------GATLELFSGFLHHDPEHWPEPKKFIPE------RFTPEAK---------ANRHPFVYLPFGAGP-----------RNCVGM-RLAQLEIRMALAHLFHRFSVVSCSETKVP-----LDLKTFSTTAP-------KNGIFVKITRRNV----------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP5A6 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKTLGDFLNVFNIEANTVSVTFSLVLIFLGLLYWYSVYPFSVLSRC----------------------------GIKHPKP-VPFFGNMLMFREG------------------FYKPLIDI-----VKTHGKVCGYYFGRKPVVMIADPDVLRKVMVKD------FSSFANR-SNGYSTKPF-EDCLIMLK-DEQWKRVRSIVTPSFSAAKLKEMVP------FISTATDTLMNNLNVHAE--------------SGEAFDIHKCFGCFTMDVIASVAFGTQVDSQNNPN----NSFVRNTLEFLAMPFFRPLVVVS-FLFPAIMAPFVRFVPNKKRIELDNFFISIIHKIIMQREE------QPPDQRRRDFLQLMLDARNSQESVSLEHFDTTKHSDELDDKNQQKQ-SAVDQENGHLRSEESLMRCSQRKMMTEDEIMGQAFIFLVAGYETTSNTLAYTCYLLALHPECQRKVHEELDDFFTRHD------------------------------------------------------SPDYTNIQELKYLDMVVCEAL-RLYPSIFKITREVANDYMIK-GQLIPK------GAKVEILTCFLHQDPEHWPEPEKFIPE------RFTPEAK---------ANRHPFVYLPFGAGP-----------RNCVGM-RLAQLEIRMVLVHLLHRFNVVACSETKVP-----LNLKSNLTLSP-------KNGIYVKMTRRNEEGGKK------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP7A1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MISIALIWGVLVGFCC-------------------------LLWLALGIRRRQPGEPAVENGFIPYLGCALQFGAN-----------------PLQFLRSRQ------KKYGHIFTCKIAGRYIHFLCDPFSYHSVIRQGRH-------LDWKKFHFSTSVKAFGHDSFDPRHGYTTENLHQTFMKTLQGEALTSLI---------ETMMGHLQDVMLKSDT-----------LGSNK-DQWQVDGIFAFCYKVMFESGYLTLFGKELGDD--------KCRA----HQEAQKSLVLNTLENFKEFDKIFPALVAGLPIHVFKSAYSARENLAKTMYAE--------NLSKRHHMSDLISMRMIL--------------------------------------------NDSLSTFNDVSKARTHVALLWASQANTLPATFWSLFYMIRCPDAIKAAYTEVQTVLRDLGLTPDPDGPIL--------------------------------------------NLTRNQLDNMPVLDSIIKEAMRLSSASMNVRVAKEDFLLHLDNQEAYHIR---KDDVIALYPP-MLHFDPKIYEDPYEYKFN------RFLDEKGEEKTTFYRNGQRLRYFYMPFGSGV-----------TKCPGR-FFAVCEIKQFLTLMLSYFDMELLDPAIKVPPLDQSRAGLGILQPTY--------DVDFRYKLKPKL---------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP7C1 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFPSWPPPQILPVVCNQSSDVQEDSEEQEEDWTWSLSQISSCLCCICSPCRRDGEPPLIQGWIPFLGKALEFRKD-----------------AHKFLEEQR------RTYGDVFTVLIGGKYMTFIMDPLLYPSIIKHGRQ-------LDFDKFTMRVAPRVFGYT--KTELFPGLWDQVKRCYQLLQGDSLTPLT---------ESMMANLMLVFRQDHL-----------DQG---HSWRTGNMYEFCALVMFEATFLTIYGKPETG--------------------IRHHQMDQLWNNFVEFDNMFPYLFAEVPIWLLGRTKAIRQKLISHFLPQ--------RMSRWSNTCQFIRRRSEL--------------------------------------------FDQYDKLKDVDKAAHHSTILWASVGNTVPATFWAIYHLAAHPEALQVVRQEILDVLRANGMEFSPR-RDV--------------------------------------------MLSRDQLDKLVFLESSISESLRLSSASMNIRVAQEDFSLRLDAERSVAVR---NGDIIALYPQ-SVHLDPEIYEDPQTFRFD------RFVQD-GREKTDFQKDGQKLKHFLMPFGSGS-----------SKCPGR-YFAINEIKQFVCLLLLYFDLQLEDGQNR-PLLDSSRIGLGILHPSS--------DVRFRYRLRAE----------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP8A1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIWVVPLLVLLYFTLTRR--------------------------------WRSKNEPPLDQGLIPWLGHALEFAKD-----------------VPKFITRMK------LKHGDIFTVRVAGHYVTLLLDPHSYDAVIGDPTS-------LDFSRYAQVLMRRIFSLELPLEQPAK----AKTMMKTHFLGKSLSALN---------STMSRHLEALLKTE-------------MPQNQRS-WKEEGLFNLSYGLIFKAGYLTLFAGERNNN---------------------GPGASEVYQEYKAFDSLLCKLARGMLKAEEKKTAQSAQRRLWELLAP--------AGLTGDSGSSSWLHAYRR--------------------------------------------LLQEDGVDEESQRKAVLMQLWASQGNVGPAAFWLLGYLLTNPDALLAVREEFGKLEKSGSPLLDR-------------------------------------------------------AVNTPVFDSVLEEILRLTAAPFITREVVQEKILCMADGQEYLLR---KGDRVCLFPFISPQMDPEVYREPQRFKHD------RFLNEDGSAKRDFYKGGKQLKYPTMPWGAGA-----------NGCVGK-PFAISTIRKFVYLLLTNYDLELCDPNAQMPEINASRYGFGMLQPEG--------DLPIRYRPRDTQL--------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP8A2 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLWIFLLLSVLFMLFHLYCTRS-----------------------------RRKNEPPLDKGHIPWLGHALEFGKD-----------------AAKFLARMK------EKHGDIFTVCVAGHYVTVLLDPSSFDGVLGDTVS-------FDFSRIRGQLVKRIFSLQLPNSDPAL----ERAWMETHFQGVSLRKLS---------SSMSSHLYNLLVTN-------------RNSCSSSMWTEDELFGFCYSLLFRAGYLTLFEKEDN--------------------------AAAVYREFRKFDELLTKLARSTLKREEGKIARASQEQLWELLSP--------RCLNEDS--DSWQQSYRR--------------------------------------------FLREQGMDADVQNKALLLQLWTTQCNAGPAAFWILGFLLTHPEAMEAVKLEIRGLSTLQNTSLQRPA------------------------------------------------LNQLEAQHTPVFDSVLKETLRLTAAVMINREVMQEKVLRMADGREYLLR---RGDRVCLFPFLSPQMDPEIHQEPQMFKYD------RFLTPSRTLKDDFYKDGRRLKYYIMPWGAGR-----------NSCVGR-EFAAAAIRQFVFLLLTHLDLELCHPDAKLPPVNPKRYGFGMLQPDG--------DLQVRYRLKTTRSADP------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP8A2.like ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENLSASIIADLLIKVSDGVIGSDCTCSR------------------HTLQLISIKERRKNEPPLDKGHIPWLGHALEFGKD-----------------AAKFLARMK------EKHGDIFTVCVAGHYVTVLLDPSSFDGVLGDTVS-------FDFSRIRGQLVKRIFSLQLPNSDPAL----ERAWMETHFQGVSLRKLS---------SSMSSHLYNLLVTN-------------RNSCSSSMWTEDELFGFCYSLLFRAGYLTLFEKEDN--------------------------AAAVYREFRKFDELLTKLARSTLKREEGKIARASQEQLWELLSP--------RCLNEDS--DSWQQSYRR--------------------------------------------FLREQGMDADVQNKALLLQLWTTQCNAGPAAFWILGFLLTHPEAMEAVKLEIRGLSTLQNTSLQRPA------------------------------------------------LNQLEAQHTPVFDSVLKETLRLTAAVMINREVMQEKVLRMADGREYLLR---RGDRVCLFPFLSPQMDPEIHQEPQMFKYD------RFLTPSRTLKDDFYKDGRRLKYYIMPWGAGR-----------NSCVGRDEFTIISSRPFVFLLLTHLDLELCHPDAKLPPVNPKRYGFGMLQPDG--------DLQVRYRLKTTRSADP------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP8B1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGLLLPILFTIFVALVGGLYVLG-------------------------VFRKRRPGEPPLDKGLIPWLGHVLEFRRD-----------------TFKFLERMK------KKHGDVFTVQLAGNYITFLQDPLSFGAFVKESRKK------LDFNTFAEQMVYRVFGYVPIEEDYHI----LHSSSNKHLKGEGLDVMT---------EAMMSNLQNLMLHS-------------VSS-DQKTWKEDGLFMYSYNIVFRAGYLALFGNVPHKS--------EGGE--EQAKEKDRSQSETLFYEFRKYDQLFPNLALGVLSPKQQWEVDRLQTFFWDAVSV--------QKMKANDNISRWVWDMHQ--------------------------------------------AKEELGVKESNINKYLFVLLWASQGNTGPSSFWLLLFLLKHPEAMKAIREEVDEVLKETGQEVQPGCPLI--------------------------------------------NLTHEMLTKTPILDSAVEETLRLTAAPLLLRAVLQNMTLKMADGREYFIR---EGDRMGIFPYEDVHLDPEIHPDPLSFKYD------RFLNPDGSKKTDFYKAGKKVKYYNMPWGAGV-----------SMCPGR-FFATNELKQFVFLMLIYFEFELMNPDEKIPEIDFRRWGFGSMQPVR--------DVQFRYRLRY------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP8B14 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGLLLPMLFTIFVALVGGLYVLG-------------------------VFRKRRPGEPPLDKGLIPWLGHVLEFRRD-----------------TFKFLERMK------KKHGDVFTVQLAGNYITFLQDPLSFGAFVKESRKK------LDFNTFAEQMVYRVFGYVPIEEDYHI----LHSSSNKHLKGEGLDVMT---------EAMMSNLQNLMLHS-------------VSS-DQKTWKEDGLFMYSYNIVFRAGYLALFGNVPHKS--------EGGE--EQAKEKDRSQSETLFYEFRKYDQLFPNLALGVLSPKQQWEVDRLQTFFWDAVSV--------QKMKANDNISRWVWDMHQ--------------------------------------------AKEELGVKESNINKYLFVLLWASQGNTGPSSFWLLLFLLKHPEAMKAVREEVDKVLKETGQEVQPGCPLI--------------------------------------------NLTHEMLTKTPILDSAVEETLRLTAAPLLLRAVLQNMTLKMADGREYFIR---EGDRMGIFPYGDVHLDPEIHPDPLSFKYD------RFLNPDGSKKTDFYKAGKKVKFHNMPWGAGV-----------SMCPGR-FFPTNELKQFVFLMLIYFEFELMNPDEKIPEIDFRRCGLGSMQPVR--------DVQFRYRLRY------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP11A1 ----------------------------------------------------------------------------------MAARLRLCRGPVTQP---------------------------------------------------------------------------------------LSCLEEPTASGFVRCSSSSSSMPVIRQTYSESSGSIVRPFG-----------------------------EIPGLW-KNGVVNLYNFWK----------------LDGFRNLHRIMLQN--FNTFGPIYREKIGYYESVNIIKPEDAAILFKAEG---HYPKRLKVEAWTSYRDYRNRKY-GVLLKNGEDWRSNRVILNKEVISLKMLENFVP-----LLDEVGQDFVARVHKKIKRSGQN----------KWTTDLSQELFKYALESVSSVLYGERLGLMLDYI----DPEAQRFIDCITLMFKT--TSPMLYVPPALLRQIGSKVWRDHVEAWDGIFNQADRCIQNIYRQL-------RQETGPSK-----KYPGVLA------------------------------------------TLLLLDKLSIEDIKASVTELMAGGVDTTSITLLWTLYELARHPNLQEELRAEVAAARAASQG------------------------------------------------------DMLEMLKRIPLVKGALKETL-RLHPVAVSLQRYIT-EDIIIQNYHIPS------GTLVQLGLYAMGRDPKVFLRPEQYQPS------RWLRTETH------------YFRSLGFGFG-----------PRQCLGR-RIAEAEMQLFLIHMLENFQVEK-QRSVEAQSTFE-----LILVPDK--------PIILTLKPLQANR--------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP11C1v1 -----------------------------------------------------------------------------------MRNVSTVSVRAQGACGSRFLGIAPQRGL-------------------------------------------------------------------------CVAAAGTVVDG-----NVDGSKGAVKAVRKRGVDGQVRRFE-----------------------------EIPHTG-RNGWINLVKFWR----------------ENRFQQLHKHMEGT--FNALGPIYREKVGTLSSVNILMPSDISELFQSEG---LHPRRMTLQPWATHRETRNHSK-GLFLKNGEEWRSDRLQLNKEVMLSAAVKRFLP-----LLDEVAKDFCRMLQMKVEREGRG-EEA----KCSLTIDPSPDLFRFALEASCHVIYGERIGLFSSSP----SLESQKFIWAVERMLTT--TPPLLYLPPRLLLRLGAPLWTQHATAWDHIFSHAEARIQRAYQRL-------MSSQSRGS-ETGGQYTGVLG------------------------------------------QLMEKGQLSLDLIKANITELMAGGVDTTAVPLQFALFELGRNPEVQDMVRQQVRTSWAQAGG------------------------------------------------------DPQKALQGAPLLKATIKEVL-RLYPVGITVQRYPV-KDIVLQDYHIPA------GTMVQACLYPMGRSALVFEDPLRFHPS------RWSSSREDGRR-----GEAGAFRSLAFGFG-----------ARQCVGR-RIAENEMQLLLMNILLNFHLSV-PSSEDLKTTVT-----LILQPET--------PPKITFSKL------------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP17A1 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAWYLCLLVFVAVGLAVLAWHLKVKS---------------------------SRGPQEPPHLPALPLIGSLLSLRSP---------------HAPHVLFKELQ------KKYGQTYSLMMGSHRVVIVNQRVHAKEVLLKRG---KVFAGRPRTVTTDILTRDGKD--IAFGDYSAAWRFHRKIVHGALCMFGEGSAS-------LERIISAEAQSLCQTMSEA-----------AAVGLPLDLSPELTRAVTNVVCSLCFNSSYCRGDPEF----EAMLRYSQG-IVDTVAK----DSLVDIFPWLQIFPNADLRLLKQCVAIRDKLLQKKYEEHKADY-------SDHMQRDLLDALLRAKRSAENN------------------------------------NTAEISAESVGLSDDHLLMTVGDIFGAGVETTTTVLKWAVTYLIHYPEVQRRIQEELDTKIGVDRY------------------------------------------------------PQLSDRGSLPYLEATIREVL-RIRPVAPLFFPHVALSDTSIGDFKVRK------GTRVIINLWSLHHDEEEWDKPELFDPG------RFLNSEGT-G------LTVPSSSYLPFGAG-----------IRVCLGE-ALAKMELFLFLSWILQRFTLSVPPN-HSLPSLEG-KFG--VVLQPV--------KYKVTATPRPGWEQP-KDKAC------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP17A2 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLAALL---ASFSPCVLLLFLAASLLLLSLISARNR---------------------------PPA--SIPCLPHLPVLGSLPWLGGG---------------LPPHLLFTQLG------HRYGPLFALFVGPHLTVVVNDHRHAREVLLQRG---RDFAGRPNMVTTSLLTRGGKD--IAFSDYSALWKLHRRLVHNSFSLFGEGSSR-------LQDIFLSSVDSLCVELLSN-----------GTRG--FDPSPAVTRAVTNVVCTLVFSGTYRHGDSEL----QEVIRYNNG-IVETIAR----GGLVDIYPWMKFLPNSSLSKLKECIAVRDKLLSRKLEEHKASL-------SDGDPHDLLDALLKGQTGN-GR------------------------------------GQKSHGSEEEGITDDHVLMTAAEAFGAGVETTSTTLLWILAYLLHHPEVQERVQKELDEHVGSERA------------------------------------------------------VSMSDRSQLPYLECVINEGM-RIRPVSPVLIPHTALTDSHIGGHAVTR------GTRVLVNMWSIHHDAQHWDRPDLFHPD------RFLDDQGQ---------RATPSCFLPFGAG-----------PRVCVGE-SLARLELFLFLSSLLQRMSFKLPDG-VSPPNLQG-RLG--VVLQPL--------PYKVMVTPRPGWEGGAK----------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP19A1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------MDLIS-CDRAMTPEGFDGAVADLNSRSSNATG-SRSPGVPVATRTLLLLVCLLLVAWSHTD----------------------------RKT-IPGPSFCLGLGPLLSYLR-----------FIWTGIDGTASNYY-----NKKYGDMVRVWINGEETLILSRASAVHHVLRSGK------YTSRFGSQQGLRCLGMNERGIIFNNNVTLWKNIRTYFAKALTGPNMQQTVE------VCVSSTQSHLDDLDSLT------------------HVDVLSLLRCTVVDISNRLFLDVPLD----------EKELLLKIQKYFDTWQSVLIKPDVYFRFSWIQQKHKAAAQELQDAIEGLVEQKRREMEQAEKLD-----------NINFAADLIFAQNHGELS-------------------------------------------------ADNVRQCVLEMVIAAPDTLSISLFFMLLLLKQNPDVELQLLQEID--AVVGEE-----------------------------------------------------QLQNQDLQKLQVLESFINECL-RFHPVVDFTMRRALSDDI---GFRVRK------GTNIILNTGRMHR-TEFFHRAQEFSLE----------NFQ---------KNAPRRYFQPFGSGP-----------RACVGK-HIAMVMMKSILVTLLGQFSVCPPRDLTLDC----LPQTNNLSQQPVEHQ-EEAGGLSMRFLPRQRGRWPSP----------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP19A2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMQPEVLSVGQT----VVSCLSEVTSLLLLLLLLFLLITAWSRT----------------------------HHSHTPGPSFLAGLGPILSYSR-----------FIWTGIG-TACNYY-----NRKYGSIVRVWINGEETFILSKSSAVYHVLRSDN------YICRFGSRRGLKCIGMEGQGIIFNSDVPLWKKVRTYFSKALSGPSLRRTVR------ICVSSTAKHLDSLQDVTDP--------------SGHVDALSLLRAIVVDISNRLFLRVPLN----------EKDLLMKIQNYFETWQTVLIKPGVFFKLGWLYNKHKRAAQELQDEMESLLEVKRKMIDDAEKLDD----------DRDFATELIFAQNHGELS-------------------------------------------------ADNVRQCVLEMVIAAPDTLSISLFFMLMLLKQNPDVELKMVEEMN--AALNGK-----------------------------------------------------AIEDVDYEGLKVMERFISECL-RFHPVVDFTMRKALEEDNID-GMKIRK------GTDIILNLGLMHK-TEFFPKPKEFNLT----------NFD---------NTVPSRFFQPFGCGP-----------RSCVGK-HIAMVMMKATLITLLSRYTVCPRQGCTLDS----IRQTNNLSQQPVE---DELG-LAMRFIPRTQKQSAVNSETE------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP20A1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLDFAIFAVTFVIILVGAVLYLYPSSRRASG-----------------------------IPGLNPTDEKDGNLQDIVNK---------------GSLHEFLVSLH------QEFGSVASFWFGGRPVVSLGSVKPLQQHINPNH------TTDSFETMLKSLLSYQSG-----MGGGPNESVIRKKLYESAINNSLKNNFS------VVLKVVEELVGKWSSFP---------------EAQHIPLCAHLLGLALKTVTQLGLGERFRCDAEVIS------FRKNHDAIWSEIG--------KGYMDGSLEKSASRKAHYEAALSEMESMLLSVSKERKAQ----------RKQTVFVDGLLQSSLTER-----------------------------------------------------QIMEDCMVFTLAGCVITANLCIWALHFLSTSEEVQDKLYKELEDVLGSDPV-------------------------------------------------------SLDKIPQLRYCQQVLNETV-RTAKLTPVAARLQEVEGKVD-QHVIPK------ETLVIYALGVVLQDPDTWSTPYRFDPD------RFEEESAR-----------KSFCLLGFSGN------------QTCPEL-GFAYTVATVLLSTVVRRLKLHQLEGQVAEVRSE-------LVSSPK-------EETWITVSSRS------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP21A1 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALEISLISIGAVFLLVLLLLVVISGQRDSHFLGKGKVGVQSG---------LLQHLYQFLHCSPAPTFPGPPSHFLFGNMMELTHD---------------HMP-IHLTDLA------QRYGSIYRLKFGNTTMVVLSSGEAIREALVKKW---SDFAGRPISYTGNIVSGGGHN--ISLGDYTEEWRAHRRVVHIALLRCCQQS---------LHGVIERQALHLRKVLLDY-----------HMKP--ADLSEDFTVAASNIITTLAFGKEYDKKSTEL----QQLHNCLNE-IVGLWGS--SWISALDSFPLLRKLPNPVFARLLKEVARRDEIIKHHLDDYKLQD-------KKNE-HAITGSLLQALDKH-----------------------------------------HNTEHGGVLLTDVHVHMATVDLLIGGTETTSAWLNWTVAFLLHRPEVQTRVYEELCTVLE-ERY------------------------------------------------------PKYSDRHRLPVLSSLISEVL-RLRPVAPLAVPHRAIRDSSIAGYFIPK------NTVIIPNLFGAHHDPAVWPEPYSFKPE------RFLEGGGG-----------SARALMPFGGG-----------ARLCLGE-SVAKMELFLFTAYLLRDFQFVLPEGEASLPDLRG-VAS--VVLKIK--------AYRVVARPRPLTEA-------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP24A1 ----------------------------------------------------------------------------------MRAQIQKVPQIVELLKK---------------------------------------------------------------------------------------KTVGLQHFKPTSSVCVLEQKDAVEAAPCPHAASRAHSLD-----------------------------SMPGPTNWPLVGSLVELLR----------------KGGLTRQHEALVDY--HKKFGKIFRMKLGSFESVHIGAPCLLEALYRKES---NYPQRLEIKPWKAYRDLRNEAY-GLLILEGKDWQRVRSAFQQKLMKPTEVVKLDG-----KINQVLVDMVDRIGKVNVDGKIDD--------------LYFELNKWSFETICLVLYGKRFGLLQEKV----NEEAMSFITAVKTMMST--FGMMMVTPVELHKRFNTKTWQDHTAAWDRIFSTAKVYIDKKLKRN-------AIR----------DPDDLIG------------------------------------------EILHQSSLSKKELYAAITELQIGGVETTANSMLWVIFNLSRNPGAQKKLLQEIREVVPSGQN------------------------------------------------------PCGEHIKNMPYLKACLKESM-RLSPSVPFTSRTLD-KDTVLGDYTIPK------GTVLMINSHALGSNEEYFDDGKHFRPE------RWLRE-----N-----STINPFAHVPFGIG-----------KRMCIGR-RLAELQLQLAMCWLVRDYEIVATDNEP-LDVIHS-----GLLVPSR--------ELPVAFIRR------------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP26A1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALSTLLASLLCTIVLPVLLLLVALRLWELYWSRGRDPSC-------------------------AAPLPPGSMGFPFLGETLQLILQ------------------RRKFLRMK-----RQRYGFIYRTHLFGTPTVRVTGADNVRRLLLGEH--------RLVSAQWPTSVRTILGPDTLSNLHGSQHKTKKRAIMRAFSRESLELYIP-----EIQEEVRAAVTEWTVKDS------------------CVLVYPEMKRLMFRIAMRILLGFKPEQIRIDE----QQLVEAFEEMIRNLFS-------------LPIDVPFSGLYRGLKARNFIHSKIEENIKKKVLE---------SEQGLKHRDALQQLIDSSR--------------------------------------------KNNEPFSMQAIKESATELLFGGHETTASTATSLVMFLGLNPEVVDKLRQELLEK--EEQG-----------------------------------------------MDLQS--LNLESLEQLKYAGCVIKETL-RMNPPVP-GGFRVALKTFQLNGYQIPK------GWNVIYSICDTHDVAEIFPNKEDFQPQ------RFITKPSAD---------SSRFQYIPFGGGS-----------RMCVGK-EFAKVLLKIFLVEVVTKCHWTLLNGP-PTMKTGP-------TVYPVD-------NLPTKFTSYSQN---------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP26B1 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLFDSFDLVSALATLAACLVSMALLLVVSQQLWQLRWAATRDRSC-------------------------KLPMPRGSMGFPFIGETCHWLLQ------------------GSSFHASR-----RQKYGNVFKTHLLGRPLIRVTGAENIRKVLMGEH--------TLVTVDWPQSTSTLLGPNSLANSIGDIHRKRRKVFAKVFSHEALESYLP-----KIQQVIQESLRVWSSNPE------------------PINVYRESQRLSFTMAVRVLLGFRISEEEMR------HLFSTFQDFVNNLFS-------------LPIDLPFSGFRKGIRARDVLQKSVEKAIREKPLC---------SQ-GKDYSDALDVLMESAK--------------------------------------------ENGTELTMQELKESTIELIFAAFATTASASTSLIMALLRYPHVLERLREELRARGLLHNG-----------------------------------------------CLCPEGELRLDTIISLKYLDCVIKEVL-RLYTPVS-GAYRTAMQTFELDGVQIPK------GWSVMYSIRDTHDTAAVFKDVEAFDPD------RFSQERSEDK--------EGRFHYLPFGGGV-----------RSCLGK-QLATLFLRLLAIELASTSRFELATRQFPRIITVP-------VVHPVD-------GLKVKFYGLDSNQNEIMAKSDELLGATV------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP26C1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFPLAQFGVLSALATALTSLLSALLLLVLTRQLWSLRWTLTRDKES-------------------------KLPLPNGSMGWPLVGETFHWLFQ------------------GSNFHISR-----RERHGNVFKTHLLGKPVIRVTGAENIRKILLGEH--------SLVCTQWPQSTRIILGPNTLVNSVGDLHKKKRKILAKVFSRGALESYLP-----RLQDVIKSEVAKWCSEPG------------------AIDVYSSAKSLTFRIAVSVLLDLQLEEERIH------YLAKIFEQLMNNLFS-------------LPIDAPLSGLRKGIKAREILHANMEKIIEEKMAR---------QQVEDEYQDAFDYMLSSAK--------------------------------------------EHSQQLSIQELKETAVELIFAAHSTTASASTSLILQLLCHPAVVEKARVELDAEGLGYQQN---QSHNSSCVTVEKEQDDAETTHLLNSYG-------QNAGDEFPRSKSHIPYLTLDKLSQLQYIDCIVKEVL-RFLPPVS-GGYRTALQTFELDGYQIPK------GWSVMYSIRDTHETAPVFQSPELFDPD------RFGPERDESR--------SSRFSYVPFGGGV-----------RRCVGK-ELAQIILKTLAVELIGTCKWTLAMENFPKMQTVP-------IVHPVN-------GLHVRFSCNSLL---------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP27A1 -----------------------------------------------------------------------------------MAAWLSQRSLLRSSR----------------------------------------------------------------------------------------WLCP--VSRGRVSIR-DVGRTTSAPGALHALQDKPRTAE-----------------------------DLPRV---RFLELLYRMVF----------------QGFYNRLHELQIYE--KQLYGPIYNSG---LKSVSVNTPQLLEELLRKDE---KFPSRGDMSLWTEYRDMRGLGY-GPFTEEGKQWYNLRVVLNKRMLHPKDSAQYAG-----VINEVVTDFIRRIEYLRRRSPTGD----------LVSDISNELYLFSLESIASVLFETRLGCLEKEI----PAGTQEFIDSIAQMFS---YSMVVVILPKWSRRLLP-YWGRYIAGWEGIFTFAKMLIDKKMEDI-------QQRVDRNQ----DVQGEYLT------------------------------------------YILSNTQMSAKDVYGSITELLLAGVDTTSNTLTWALYQLSKNPQVQDRLYEEVSSVVPADRI------------------------------------------------------PTAAEVTQMPYLRAVIKETL-RMYPVVPLNARIMTEKNISVGGYQFPK------KTTFTFCHYAISHDESVFPQSFTFRPE------RWLRD--GHQR-----PN--PFGSIPFGYG-----------VRGCVGR-RVAELEMYLVLFQLIRQFEVKPDPRTGELKSISR-----TVLVPDK--------QLNLHFVDRGRRTEDRDLFHPRLCTD-------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP27A3 ---------------------------------------------------------------------------------------MLRRSLGSV------------------------------------------------------------------------------------------GLRLDRRRHEGL--------------------------------------------------------------------------------------------------LRAAIEH--KKIYGPLWKSKYGPLVVVNVASAELIEQVLRQEG---RHPVRTDMPHWRGYRELRNQAH-GPLTEMGAKWQRIRSILNPRMLKPKHVSSYSD-----TINNVVTDFIRRVAWLRDTGGQGT----------VVNDVTDELYKFAFEEYSQYLENTRMGCMNEVV----PEETEKFIFSVGEMFR---LSPIVVLFPKSLWPYLP-FWKQFVSTWDHLFKKAERLVNKKMEEI-------QQSVDLDR----NVEGAYLT------------------------------------------HLLLSDQMSVTEILGSVTELLLAGVDTTSNTISWSLYHLAKEPEIQEQLYQEVVSVCPGDKV------------------------------------------------------PNSDDISHMPYLKAVIKETL-RLYPVVPGNARVTVENEIVVGDCLFPK------QTLFHLCHYAVSYDENIFPDSHTFLPQ------RWLRGGDDKFR-----QH--PFGSVPFGFG-----------IRACLGR-RVAELEMYLLLSRLIKHYEVKPDPAGTVVKPITR-----TLLCPAT--------PINLQFLDRRAEQTEPRATAAAAAAASLIPAGGTPAVTEALQLAAPAALRTRKQPVSAAVRYTVLLVQYWTSRVKQQYVSV- Kryptolebias_marmoratus_Km.CYP27B1 -------------------------------------------------------------------------MSPDVRRSSRLLIRRMSQQALRVS---------------------------------------------------------------------------------------------VRNSFPLLRWMERWSGGSASPPAQAQAEAEVRTLD-----------------------------HMPGP---GVASFAWDLFA----------------KKGLSRLHELQMAG--LRRYGPMWKASFGPILTVHVAKPELIEQVLRQEG---QHPMRSNLSSWKDYRKLRGHHC-GLLTSEGEEWQEVRSLLGKHMLRPKAVEVYDK-----TLNSVVDDLIAKLRHR--RSSQG-----------LVTDIASDFYRFGLEGISSVLFESRIGCLDPVV----PKETERFIQSINTMFV---MTLITMALPSWLYQLCPKPWNDFYRSWDYMFDFAKSHIDQRMAAD-------AKKVARGE----SVEGHYLT------------------------------------------YFLSQTNLPMKTVYSNITELLLAGVDTISSTLSWTLYELSRHPEVQAEIRKEVLTVLGGRRI------------------------------------------------------PEATEVANMRLLKAAVKEVL-RLYPVIPANARVVPEKDIQVGGYIIPK------NTLITLCHFATSRDPSVFPNPNDFHPY------RWFSK---DQT-----HH--PYASVPFGVG-----------KRSCIGR-RIAELELYLALSRILTEFDVQPDPKGVSVKPMTR-----TLLVPKN--------VINLQFIER------------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP27C1 --------------------------------------------------------------MAVLTRVTTP-WRTFPA----RQLVFIPRALHKSAA----------------------------------------------------------------------------------------SEALEIPAPGEGAMPGRLMAPAAAEV--RSLKAAVKSLK-----------------------------EMPGP---GTLSNLIEFFW----------------RDGFSRIHEIQMEH--RQKYGKIFKSHFGPQLVVSIADRDLVAEVLRAEG---VAPQRANMESWKEYRNMRGRST-GLISAEGEDWLRMRSMLRQLIMRPRDVAVFSD-----DVNQVVDDLIRRVSALRAQQPDGA----------TVTNVNDLFFKYAMEGVAAILFECRLGCLENDI----PKETQDYISALNLMFSSFKTTMYAGAIPKWLRPVIPKPWEEFCHSWDGLFRFSVLHVDKRFAEV-------ASRLQRGE----EVRGGLLT------------------------------------------HMLTRMEMSLEEIYANVTEMLLAGVDTTSFTLTWASYLLARHPRIQQQIYTEVTQTLGPGAV------------------------------------------------------PTADDVPRLPLIRGLVKETLSRLFPVLPGNGRITQ-DDLVVGGYFIPK------GTQLALCHYSTSMDEENFANAVDFQPD------RWVRK-DSTDR-----VD--NFGSIPFGYG-----------IRSCIGR-RIAELEMHLALTRLIQRFHIGASPLTAEVKAKTH-----GLLCPAA--------PVHLQFIQREN----------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP46A1 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVFHVIISLVAKALFFLACLLLLLFLGYCLYIKYIHMKYD----------------------------KIPGPPRSSFLMGHSLMLLRIV-----------NSD-RLVHEQFLEW-----AETYGSVYRLNGLHYVYLIVTCPKATKEILMSSK---YLKDNF-YKKIFHLFGERFVGNGLITAQNHELWYKQRRIMDPAFSSLYLRGLIG------TFNERAEKLMDKLADAADN--------------NTEANMLHLLNCVTLDVIAKAAFGADLDLLTNK--SPIPKAIEACLKAIMNLVREPAFEFNPKNR--QFIKEVRKACRLLRTTGAQWIQKRKTAMQNGED------------VPKDILTQIIKTAATDENM---------------------------------------------TEEDEELMLDNVVTFFIAGQETTSGKLSFCIMELGRHPEILEKVRKEVDDVIGMKQ------------------------------------------------------DISYDDLGKLVYLSLVLKETL-RIYPTAPGTSRQIEEDMVID-GVHIPG------GISCIFDFYVTGRLERFFKDPLKFDPD------RFHPD-----------VTKPYYCHYPFSLGP-----------RSCLGK-NFAQMEAKVVMAKLLQRFDFSLVPGQT-------FDIQDTGSLRPK-------SGVICSIKHRK------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP46A2 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVFHLLWSLGAKALLIPVFLLFIAFLIYGLYLKYIHMKYD----------------------------HIPGPPRDSFFLGHSPTLKRIM-----------KND-ELVHDKLIEW-----SETYGSVYRLNVLHFVVVCVTCPEATKEILMSPK---YLKDKFVYKKLYNLFGQRFFGNGLVTVQNHELWYKQRRIMDPAFSTLYLRGLIG------TFNERAEKLMDKLADAADN--------------NTEANMLHLVNCVTLDVIAKVAFGMDLDLLTNS--SPFPKAIETCLNAMVYYIRDLTFEFNPMNR--RFIKEAREACRLLRTTGARVIRERKTAMQNGED------------VPKDILTQIIKTAATEETM---------------------------------------------TEEDEEFMLDNFVTFFIAGQETTANQLAFCIMELGRHPEILEKVRKEVDDVIGMKQ------------------------------------------------------DLSYEDIGKLTYLSQVLKETL-RMYSTVPGISREIQEDMVID-GVHIPG------GVSCMLNSYVSGRLERFFKDPLKFDPD------RFHPD-----------APRPYYCYYPFALGP-----------RACLGQ-NFAQMEAKVVMAKLLQRFDFSLVPGQT-------FEIRDTGMLRPK-------SRVVCSIKHRK------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP46A4 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVFQLLLGFVPQMLLILFFLLFIAFLGFCLYIKHIHMKYD----------------------------HIPGPPRDSFLFGHSPTILKTM-----------LND-KNLHDKFLEW-----SETYGLVYRVNALHYVFLIVTCPEATKEILMNQK---YPKDKFTYKKISHLFGQRFLGNGLVTAHEHEVWYKQRRVMDPAFNNLYLRGLMG------TFNERAEILMDKLVDVADN--------------NTKANMLHHFNCITLDVIAKVAFGMELDLLKNS--SPLPKAIETCLKGMVFYIRDFFFQFNPKNR--RFIKEVREACRLLRTTGAQWIQRRKTAMQNGED------------VPKDILTQIIKTAATEETM---------------------------------------------TEEDEEFMLDNFVTFFIAGQETTANQLAFCVMELGRHPEILEKVRKEVDDVIGMKQ------------------------------------------------------DISYDDLGKLVYLSQVLKETL-RIYPTAPGTSRQIEEDMGID-GVHIPG------GISCIFDSYVSGRLERFFKDPLKFDPD------RFHPD-----------APKPYYCYYPFSLGP-----------RSCLGK-NFAQMEAKVVMAKLLQRFDFSLVPGQT-------FDIQDTGSLRPK-------SGVICSIKHRNYKNK-------------------------------------------------------------------- Kryptolebias_marmoratus_Km.CYP46A5 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVFQLLLGLGANALLILSVFLFIAFLLYCLYIKYMHMKYD----------------------------HIPGPPRDSFIFGHSATLSRIM-----------KSG-GNVHEKFLEW-----SETYGPVYRINGLHLVTVCVTCPEATKEILMSPK---YPKDKFVYNRLFGLFGRRFFGLGLITAQNHELWYKQRRIMDPAFSSLYLRGLMG------IFNERAEKLMDKLTEFADN--------------KTEANMLHLLNCVTLDVIAKVAFGMDLDLLQKS--SPFPKAIELCLKGMVYYARDLFFEYNPKNR--RFVKDVREACDLLRTTGAQVIQKRKTAMQNGED------------VPKDILTQIIKTAATEENM---------------------------------------------TKEDEEFMLDNFVTFFIAGQETTANQLGFCVMALGRHPEILEKVRKEVDDVIGMKQ------------------------------------------------------DISYDDLGKLVYLSQVLKETL-RIYPTAPGTSRQIEEDMVID-GVHIPG------GISCMFDSYVTGRMERFFKDPLKFDPD------RFHPD-----------APKPYYCYYPFALGP-----------RSCLGQ-NFAQMEAKVVMAKLLQRFDFTLVPGQT-------FDIQDTGTLRPK-------SGVICYIKHRK------------------------------------------------------------------------ Kryptolebias_marmoratus_Km.CYP51A1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDFYQMSTKLLGDTVGETNGSLTSVVLAGFFITLTVGYVSKRLLKE-------------------------SSSDKNLKHPPYIPSSIPFLGHAIAFGKS-----------------PIEFLENAY------EKYGPVFSFTMVGKTFTFLLGSEAAALMFSSKNDE------LNAEDVYSKLTTPVFGKGVAYDVPNHVFLEQKKMFKTGLNSVRFKQHV---------KLVEAETIEYFQRWG-------------------DSGERNLFEALSELIILTASSCLHGQEIRSM--------LNER--------VAQLYADLDGGFSHAAWLLPSWLPLPSFRKRDKAHVEIKKMFFKVIEK--------RRSSGEKVDDILQTLIDAT-------------------------------------------YKDGQPMNDNEVAGMLIGLLLAGQHTSSTTSAWLGFFLARDKALQEHCYAEQKAVCGEHLPPLDYD-----------------------------------------------------QLKDLSLLERCLKETLRLRPPIMTMMRMARTP----QAAVGYTIP---VGHQVCVSPTVNHRLR-DTWVERMDFQPD------RYLNNNPAAG---------EKFAYIPFGAGR-----------HRCIGE-NFAYVQIKTIWSTLLRMYEFDLVD--GYFPTINYT----TMIHTPH--------NPIIRYKRRKQ----------------------------------------------------------------------- Oryzias_latipes_OlCYP11A2 -----------------------------------------------------------------------------------MARWHMCRSTVGLP---------------------------------------------------------------------------------------LSWAEEPIASG----ARSSSSMPVDSGSIPGEQQRCAGLSM-----------------------------RFPDRW-KNGLVNLYNFWK----------------LDGFKNLHRIMVQN--FNTFGPIYREKIGYYESVNIIKPEDAATLFKAEG---HYPKRLKVEPWTSYRDYRNRKY-GVLLKNGADWRSNRVILNKEVIFLKMLENFVP-----LLDDVGQDFVARVHKKIKRNGQN----------KWTTDLSQELFKYALESVGSVLYGERLGLLLDYI----DPEAQHFIDCITLMFKT--TSPMLYIPPSVLRRIGSKVWRDHVDAWDGIFNQADRCIQNIYREL-------RLETGTSE-----KYPGVLA------------------------------------------SLLMLDKLSIEDIKASITELMAGGVDTTSITLLWTLYELARHPSLQEELRLEVAAARARSQG------------------------------------------------------DMMEMLKRVPLIKGAIKETL-RLHPVAVSLQRYIT-EDIVIQNYHIPA------GTLVQLGLYAMGRDPKVFFRPEQYQPS------RWLRTETH------------YFRSLGFGFG-----------PPQCLGR-RIAETEMQIFLIHMLENFRVEK-QRHIEVQSTFE-----LILLTDK--------PIILTLKPLQANP--------------------------------------------------------------------- Oryzias_latipes_OlCYP11C1 -----------------------------------------------------------------------------------MSTGVAACVRASGTSGSRFLGPGQPKVL-------------------------------------------------------------------------CTTAAGTVVDG-----KLET----VKAVRKRGVDGRVRGFE-----------------------------EIPHTG-RNGWINLLKFWR----------------ENRFQQLHLHMERT--FNALGPIYREKVGTLSSVNILLPADISEMFKSEG---LHPRRMTLEPWATHREIRNHRK-GVFLKNGEEWRSDRLQLNKEVMMSAAVRRFLP-----LLDDVAKDFCRLLEDRVEREGRGAEEA----KRSLTIDPSPDLFRFALEASCHVLYGERIGLFSSSP----SLESQKFIWAVERMLTT--TPPLLYLPPRLLLRVGAPLWTEHATAWDHIFSHAEARIQRAYQRL-------SSSQGSGTVAAGGLYGGVLG------------------------------------------QLMEKGKLSLDLIKANITELMAGGVDTTAVPLQFGLFELGRNPEVQDRVRQQVKRSWAQAGG------------------------------------------------------DPQKALQGAPLLKGTIKEIL-RLYPVGITVQRYPV-HDIVLQNYHIPA------GTMVQACLYPMGRSSQVFEEPLNFDPG------RWSVSREKGQR-----GEVMGFRSLAFGFG-----------ARQCVGR-RIAENEMQLLLMHILLRFHLSV-PSSEDLQTTAT-----LILQPKT--------PPRITFSKL------------------------------------------------------------------------- Oryzias_latipes_OlCYP17A2 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLSFLLSYVSTVSPPVLLVFIVLVVALVFLSYDRRRG--------------------ERPSSLPPARSSIPCLPQLPILGSLPWLGGG---------------LPPHLLFTKLA------HRYGSLFGLFLGPHYTVVVNSHQHAKEVLLQRG---RDFAGRPSMVTTELLTRGGKD--IAFSDYSPLWKLHRRLVHNSFTLFGEGTSR-------LQDVVFSAVDSLCSELMSN-----------GSRG--FDPSAAVTRAVTNVVCTLVFSSTYRHGDAEL----QEVISYNNG-IVETIAR----GGLVDIYPWMKVFPNSSLRKLKECIAVRDRLLTRKLEEHKASL-------AEGDPSDLLDALLKGKKG----------------------------------------GPKSHGLEGEGITDDHVLMTAAEAFGAGVETTSTTLLWILAYLLHHPEVQQRVQKELDENVGADRA------------------------------------------------------ANLSDRGHLPYLDCVINEGM-RIRPVSPVLIPHTAMTDSSIGGHAVRR------GTRVLVNMWSIHHDPQNWDKPDLFQPE------RFLDDQGN---------RATPSCFMPFGAG-----------PRVCVGE-SLARMELFLFLSSLLQRMSFRLPEG-APPPNLQG-RLG--VVLQPM--------PYEVVVIPRPGWEGGAR----------------------------------------------------------------- Oryzias_latipes_OlCYP19A1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------MDLIPACDRTMSSS---CLVAELVSIAPNTTV-GLPSGIPMATRSLILLVCLLLMVWSHSE----------------------------KKT-IPGPSFCLGLGPLMSYLR-----------FIWTGIG-TASNYY-----NNKYGDIVRVWINGEETLILSRASAVHHVLKNRK------YTSRFGSKQGLSCIGMNEKGIIFNNNVALWKKIRTYFTKALTGPNLQQTVE------VCVTSTQTHLDNLSSLS------------------YVDVLGFLRCTVVDISNRLFLGVPVD----------EKELLQKIHKYFDTWQTVLIKPDIYFKFSWIHQRHKTAAQELQDAIESLVERKRKEMEQAEKLD-----------NINFTAELIFAQGHGELS-------------------------------------------------AENVRQCVLEMVIAAPDTLSISLFFMLLLLKQNPHVELQLLQEID--TIVGDS-----------------------------------------------------QLQNQDLQKLQVLESFINECL-RFHPVVDFTMRRALFDDIID-GHRVQK------GTNIILNTGRMHR-TEFFHKANEFSLE----------NFQ---------KNTPRRYFQPFGSGP-----------RACVGR-HIAMVMMKSILVTLLSQYSVCPHEGLTLDC----LPQTNNLSQQPVEHH-QEADHLSMTFLPRQRGIWESPSPF-------------------------------------------------------------- Oryzias_latipes_OlCYP19A2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIQQEVQTLDEL----FHS-VSQVTLFLLLLMLILLFINTWRQS----------------------------HLSHIPGPSFLAGLGPVLSYAR-----------FIWMGIG-TACNYY-----NKKYGSIVRVWINGEETLILSRSSEVYHVLKSAH------YTSRFGSQKGLQCIGMDGRGIIFNCDVPLWKKTRMYFSKALSGPSLQRTVG------ICVSSTAKHLARLQDVTDS--------------SGHVDALNLLRAIVVDISNRLFLRVPLN----------EKELLQKIHNYFETWQAVLIKPDVFFKMGWLYNKHKRAAQELQDSMESLLEIKRKMINEAEKLDD----------DLDFATELIFAQNHGELS-------------------------------------------------ADNVRQCVLEMVIAAPDTLSISLFFMLMLLKQNPDVELQVVEEMN--SVLDEK-----------------------------------------------------ATESIDYESLRVLESFINESM-RFHPVVDFTMRKALEDDEIE-GTKIRR------GTNIILNIGLMHK-TEFFPKPTEFSLA----------NFE---------KTVPSRFFQPFGCGP-----------RSCVGK-HIAMVMMKAILITLLSRYTVCPRQGCTLNS----IRQTNNLSQQPVE---DEHS-LTMRFIPRTSQPHLT------------------------------------------------------------------ Oryzias_latipes_OlCYP1B1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDVTADSLDEG-------ALRNVLLTSVTLLLAFHLWLWIRR--------------------------RPTPRLPGPFAWPLIGNAAQLGN-----------------APHLYFMRMV------KKYGTVFQIQLGSRAVVVLNGD-SIRQALVKQG---PDFAGRPDFTSFRFIANGDSL--AFNT-VSDWWKTHRRVAHSTVRMFSTGNPQTKKT---FEQHVLSEFKELLGLFVAKTRE-----------VQFFQPMTYLVVSTANVMSAVCFGKRYSYDDEEF----RQVVGRNDQFTQTVGAG--SIVDVMPWLQYFPNPIKTIFDNFKKLNREFSDFIHDKVVEHRKTM-------ESCTMRDMTDAFIVALD-Q------------------------------------------IRNKTG--ALKDYVVPTLGDIFGASQDTLSTAKQWIILVLVKYPEIQQRLQKEVDRVVGRERL------------------------------------------------------PSIEDQPQLPYIMAFIYEVM-RFTSFVPLTIPHCTVTDTSIMSYPIPK------NTVIFINQWSINHDPSMWAHPDTFDPE------RFLDPEG--KL-----NKDLTSNVLIFSLG-----------KRRCIGE-ELSKLQLFLFVALIAHQCNITTHPERSPTLEYS---YG--LTLKPH--------AYVIAVSLRQDATAAP------------------------------------------------------------------ Oryzias_latipes_OlCYP1C1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALDTEFGVKGSSSIREWSGQVHPALVASLVFLFCLEACLWVRNF-------------------------RLKRRLPGPFAWPLVGNAMQLGQ-----------------MPHITFSKLA------KKYGNVYQIRLGWSDVVVVNGDRSIREALIQHS---IEFAGRPNFVSFQMISGGRSL--TFTN-YSEQWKAHRKLAQSTLRAFSSANSQTKKT---FEQHIVDEATELVKVFLQRSST-----------GQYFHPAHEFTVAAANIMCALCFGMRYGHDDLEF----TTLLQRLDRFGETVGAG--SLVDVMPWLKSFPNPVRSLYENFKNLNEEFFIFIKDKVLQHRATF-------NPKVTRDISDAIINVI--EH-----------------------------------------GEDSKLS---KDFVEATVTDLIGAGQDTMSSFMQWIILLLVKYPDVQAKLQQLIDRVVGRERL------------------------------------------------------PSTEDRNNLALLDAFIYETM-RFTSFVPVTIPHSTTSDVTIGSLHIPK------DTVVFINQWSVNHDPLKWKEPHVFDPT------RFLDENG--GL-----DKDKINSVMIFSTG-----------KRRCIGD-QIAKVQVFIFTAVLLHQCSFESDPSEPVTLDCS---Y--------------------------------------------------------------------------------------------------- Oryzias_latipes_OlCYP1D1 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLSGT------LPIAESLSASLS------SVTVVLFLIALGLMAIRVQKSRSSPFNVKD--------------DSHLDLTAFPSPPGPTPWPIVGNLFQMGN-----------------QMHLSLTLLR------AKHGDVFKLRLGSLPVVVLSGYNTIRQALVRQG---EDFAGRPELFTFSAVADGTSM--TFSEKFGPAWLLHKKLCKNALRSFSQAAPRGSGATCLLEEHVCAEAAEMLEMIREQSAKVELDSEMTDGASKGVDPVKPLVTSVANVVCALCFGKRYDHNDKEF----LTIVNINNEVLKLFAAG--NLADFFPVFRYFPSLS---LKELVQYIRRMNGFMERRIEEHMHTF-------DKNYIRDITDALIALCEDRE-----------------------------------------KSKEM-SLLSDTQIIHSVIDIFGAGFDTIIAGLQWSLLYLIKFPDVQRRIHQEIDEHIGSARM------------------------------------------------------PNFSDKSKMPFTEAFIYEVF-RHAAYVPFTIPHCTTRHTTLNGYFIPK------DTCVFINQYQVNHDKDLWGDPEQFCPD------RFLGHSG--QL-----NKELTEKVLIFGMG-----------KRRCLGD-GFARLEMFVFLATLLHGLRIENVPGQKLDLGTD---FG--LTMKPH--------PYKITVSSRFTEM--------------------------------------------------------------------- Oryzias_latipes_OlCYP20A1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLDFAIFAVTFVVILVGAVLYLYPSSRRASG-----------------------------VPGLFPTDEKDGNLQDIVGR---------------GSLHEFLVSLH------EQFGPVASFWFGRQPVVSLGSVDPLRQHINPNH------TTDSFETMLKSLLGYQAG-----AGGGANESVMRKKLYESAINNAVKNSFP------AVLKVAEELVDKWSSVP---------------EDQHIPLCAHLLGLALKTVTQLALGERFKDDAEVIS------FRKNHEAIWSEIG--------KGYMDGSLEKSSSRKRHYESALSDMEATLLAVAKDRKAQ----------RRQTAFVDALLQSGLTER-----------------------------------------------------QIMEDCMVFTLAGCVITANLCIWALHFLSTAEDVQEKLCQEVEDLFGSDPV-------------------------------------------------------SLDRIPQLKYCQQVLNETV-RTAKLTPVAARLQEVEGKVG-QHVIPK------ETLVIYALGVVLQDADTWSTPYRFDPD------RFQDESAR-----------KSFCLLGFSGS------------QTCPEL-RFAYTVATVLLATLVRRLKLRPLKGQAPEVRSE-------LVSTPK-------EETWITVSSRRG----------------------------------------------------------------------- Oryzias_latipes_OlCYP26A1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALSALLATLLCTVVLPLLLFLVAVKLWEVYLARGADPSC-------------------------ASPLPPGSMGLPFIGETLQLLLQ------------------RRKFLRMK-----RQKYGYIYRTHLFGSPTVRVTGADNVRQILLGEH--------RLVSAQWPASVRTILGSDTLSNMHGSQHRTKKKAIMRAFSREALELYIP-----VIQEEVQAAVKSWLARDS------------------CVLVYPEMKRLMFRIAMRILLGFEPEQIRTDE----QQLVEAFEEMIKNLFS-------------LPIDVPFSGLYRGLRARNFIHSKIEENIKNKVQE---------SEKGSKHRDALQQLIDSSK--------------------------------------------KSGEPFRMQGIKESATELLFGGHETTASTATSLVMFLGLNPGAVDRLRQELRDK--VELG-----------------------------------------------MDLQN--LNMESLERLKYAGCAIKETL-RINPPVP-GGFRVALRTFQLNGFQIPK------GWNVIYSICDTHDVADIFPNKEDFRPE------RFMDKSFVD---------SSRFQYIPFGGGS-----------RMCVGK-EFAKVLLKIVLVELVSRCHWTLLNGP-PTMKTGP-------TVYPVD-------NLPTKFTSYLPK---------------------------------------------------------------------- Oryzias_latipes_OlCYP26B1 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLFDSFDLVSALATLAACLVSMALLLVVSQQLWQLRWTATRDKNC-------------------------KLPMPKGSMGFPFIGETCHWLLQ------------------GSNFHASR-----RQKYGNVFKTHLLGRPLIRVTGAENVRKVLMGEH--------TLVTVDWPQSTSTLLGPNSLANSIGDIHRKRRKVFAKVFSHEALTMYLP-----KIQQVIQESLRVWSSNPD------------------PINVYRESQKLSFTMAVRVLLGFRVSEEEMK------HMFSAFQDFINNLFS-------------LPIDLPFSGFRKGIRARDILQKSIEKAIREKPMC---------SQ-GKDYSDALDVLMESAK--------------------------------------------ENGTELTMQELKESTIELIFAAFATTASASTSLIMQLLQHPTVLERLREELRSKGLLHNG-----------------------------------------------CLCPEGELRLETIVSLKYLDCVIKEVL-RLFTPVS-GAYRTAMQTFELDGVQIPK------GWSVMYSIRDTHDTAAVFKDAEVFDPD------RFSPERGEDK--------EGRFHYLPFGGGV-----------RSCLGK-QLATLFLRLLAIELASTSRFELATRQFPRLTTVP-------VVHPVD-------GLKVKFYGLDSNQNEIMAKSEELLGATV------------------------------------------------------ Oryzias_latipes_OlCYP26C1 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFQFGVLSALATALTSVLSALLLLALTRQLWSLRWSLTRDKES-------------------------SLPLPRGSMGWPLVGETFHWLFQ------------------GSNFHISR-----RERHGNVFKTHLLGKPLIRVTGAENIRKILLGEH--------NLVCTQWPQSTRIILGPNTLVNSIGDLHRRKRKVLAKVFSRGALESYLP-----RLQDTIKSEIAKWCSEPG------------------SIDVYSAAKSLTFRIAVAVLLGLQLEEERIV------YLAKIFEQLMNNLFS-------------LPIDAPFSGLRKGIKAREILHANMEKIIEEKMQR---------QQTEEEHQDFFDFMMSSAK--------------------------------------------EQDHELSIQELKETAVELIFAAHSTTASASTSLVLQLLRHPEVVEKAGVELEAEGLDFDSN---RSQIPLGVMAETAQDAFETTCLLDQG--------------FPKPRSHIPYLTLEKLSQLRYIDCIIKEVL-RFLPPVS-GGYRTALKTFELDGYQIPK------GWSVMYSIRDTHETAAVFQSPEMFDPD------RFGPEREESR--------ASRFSYVPFGGGV-----------RRCIGK-ELAQIILKTLAVELIGTCKWTLATQNFPKMQTVP-------IVHPVN-------GLHVRFSYKNPL---------------------------------------------------------------------- Oryzias_latipes_OlCYP27A1 -----------------------------------------------------------MAPPCSTSLLLATGILFTFYFTLAMAAWLSSKSVPRNGG----------------------------------------------------------------------------------------RLLSGSVFKAPVCFR-GLGRTSSASGAVSAFQDQPRTID-----------------------------DLPRV---SLLEMLYRLVF----------------QGFYNRMHELQLYE--KQRYGPIYLNG---LKAVSVNTAKLLEELMRKDE---KFPCRGDMTLWTEFRDIRGLGY-GPFTEEGKKWYDLRTVLNKRMLSPKDSAQYDG-----VFNAVVTDFIKRINFLRQGSPTGD----------LVPNIGNELYLFSLEGIASILFETRLGCLEKEI----PPGTQEFINSISAMFS---NSMAVVLIPKWGRNILP-YWRRYIAGWDGIFSFAKKLIDKKMETI-------KQRVDNNQ----EVEGEYLT------------------------------------------YLLSNTQMSTKDVYASIAELLLAGVDTTSNTLTWALYQLSKEPEVQERLYKEVSTSVPADRL------------------------------------------------------PTAAEVTRMQYLRAVIKETL-RMYPVVPVNARIVTERGITVGGYQFPK------NTPFNFCHYAISHDEEIFPESFKFKPE------RWLRD--GRER-----PN--PFGSVPFGYG-----------VRGCVGR-RIAELEMYLLLFQLIRHFEIKPDPAVGELKSINR-----TVLVPDK--------PLSLHFVNRG------------------------------------------------------------------------ Oryzias_latipes_OlCYP27C1 --------------------------------------------------------------MALLNSFAAAGLKNLQAGWTINQRIFVLRALHKSAA----------------------------------------------------------------------------------------SEALEIPATGEETMSGRLIEPTMP----VDEKTELKTLN-----------------------------DMPGP---STLSNLVEFFW----------------RDGFSRIHEIQLEH--RKKYGKIFKSRFGPQLVVSIADRGLVAEVLRAEG---VAPQRANMESWQEYRDMRGRSN-GLISAEGEDWLNMRSVLRQLIMRPKDVAVFSD-----DVNKVVDDLVKRVCTLRAQESDGA----------TVFNVNDLFFKYAMEGVASILYECRLGCLENNV----PQKTQDYIGALNLMFSSFKTTMYAGAIPKWLRPIIPKPWEEFCSSWDGLFKFSMIHVDKRFNDI-------KAQLERGE----EVKGGLLT------------------------------------------HLLVTKEMSIEEIYANVTEMLLAGVDTTSFTLSWATYMLAQHPDIQEQIHGEITRTLGPGTV------------------------------------------------------PTAEDVSQLPLIRGLVKETL-RLFPVLPGNGRIIQ-DDLVVGGYFIPK------GTQLALCHYSTSLEEENFPGALEFQPQ------RWVRK-DASDR-----VD--NFGSIPFGYG-----------IRSCVGR-RIAELELHLALIRLIQKFRIEVSPVTTEVKAKTH-----GLLCPSA--------PINLRFVDREN----------------------------------------------------------------------- Oryzias_latipes_OlCYP2AD7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIFQALFDRMDFNSWLVFGFVLLLLIDIVK-TWKPPK-----------------------------FPPGPLSVPFLGNVFTGV-------------------DFKTMEKLS------QDFGPVFSLRRGSERMVFISGYKMVKEALVTQL---DSFVDRPIVPLFHVVFKGL----GIALSNGYLWKKQRKFANAHLRYFGEGQKS-------LERYIEIESNFLCDAFK-------------EEQGRPFNPHYLITNAVGNIISSVVFGHRFEYSDPSF----RKVLELDNEAVVLSGS---ARTQLYDAFPSLLNYLPGPHQTVHANYREIVCFLRKEIEKHQEEW-------NPEDPRDYIDVYLSEMEKTK-----------------------------------------QDPQA--GFNIETLVVSTLDLIEAGTETTATTLRWGLMFMLHHPEIQEKVQEEIDRVIGQSRQ------------------------------------------------------PAMSDRPNLPYTDAVIHEIQ-RMGNIVPLGFPKMASKDTTLGGYFIPK------GTPITTILSSVLFDKNEWETPHVFNPG------HFLDSEG---------RFLKKEAFLPFSAG-----------KRMCLGE-HLAKMELFLFFSTLLQRFTFKPVPGEMPSLEGV---LG--FTHSPE--------EFRFLALPR------------------------------------------------------------------------- Oryzias_latipes_OlCYP2K27 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDLLMPLVSSPTTVIGAVFLLLVLYLASAGST-SRDLGK-----------------------------DPPGPRPLPLLGNLLQLDP----------------RRPHKALCELS------KSYGPVFTVYFGIQKVVVLAGYKTVKEALVNNA---EEFGDRDITPMFQ-DMNKGHG---ILFANGESWKELRRFALTTLRDFGMGKRI-------AEEKILEECDYLIQGLE-------------KHQGNPVDLTCPLNYATSNIISSIVYGSRFDYDDPRF----RNLVSRANETIRINGH---PLTHLYNMFPRWFRWIK-NRKIILNNVEMTVKDVKDLVKHLKETL-------NPSVCRGFVDCFLIKKQKEE-----------------------------------------DSCVKESHFTEQNLVFSVSNLFAAGTDTTATTLRWGLLLMAKYPHIQDKVHEELAKVLG-GRQ------------------------------------------------------VRVDDRKNLPYADAVIHEIQ-RVANIIPMSIPHKTNRDVTFHGYLIQK------GTTVIPLLASVLNDENEWESPHTFNPH------HFLSKEG---------KFVKRDAFMPFSAG-----------RRACLGE-SLAKMELFLFFTSLLQRFHFTPPPGVSEEELDLTPAMG--FVLAPS--------SHELCAVSLQ------------------------------------------------------------------------ Oryzias_latipes_OlCYP2K28 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIQYIFRFMP-ASVSLMWVIVGVLVLLFLYF-QL-SFFNWR-----------------------------EPPGPRPLPLLGNLFQVDL----------------KRLDQSLFDLS------KKYGPVFVVNFGPKKVVVLAGYRTVKQALVNQA---KEFGNREVTPIFY-DFNKEHG---ILFANGESWNEMRRFALSTLRDFGMGKRI-------SEQNIIEECRWLIEELE-------------KLQGKPFDNTHTISYAVSNVLSGLMFGKRFDYQDPLL----QAIVDRDNEIIYLTGT---VSILLYNMFPWLGPWLK-NWKTLMKNMEAAKTDMKKIIAELKDTL-------DPDTRRCFVDAFLTQKQNLK-------------------------------------------EVNGSHYHDDNLLYTVMNLFAAGTDTTATTIEWCLLFMAKYPHIQERVQEELNWVVG-SRQ------------------------------------------------------VRIEDRKNLPFTDAVIHESQ-RLANIAPMAIPHTTSKDVTFQGYFIKK------GTTVLPLLTSVLYDESEWESPRTFNPS------HFLDKEG---------KFLKRGAFMPFSAG-----------RRVCLGE-SLARMDIFLFFTSLLQHFSFTPPPGVSEDELDLTPVVG--FTLSPQ--------PQGLCAVRRQ------------------------------------------------------------------------ Oryzias_latipes_OlCYP2K29 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQILD-FFQSYS--SVSLVGILAVLV-LYFISQFIFNSEQHGQ-----------------------------EPPGPRPLPIIGNLMQIDL----------------KRPYKTLEEFS------KTYGPVFTVFFGGEKVVVLAGYKTVKNALVNHD---EEFGERAIPPIIQ-ELNKGLG---VLWSNGDIWRDIRRFALTNLRDFGMGKKA-------CEDKITEECQYLLEVFK-------------KFKGNAFDTTKPLNYAVSNIICSMVYGSRFEYDDPKF----TSMVDRTNRNIQLSGS---PTLQAYNMVPWLFKWVA-SRREVHECAAANRKQNQSIFSHLKETL-------NPQMCRGFVDAFLVKGQTLE-----------------------------------------KSGVTNSAFNDENLLMTVIHLFAAGTETTSTTLRWGLLLMAKYPKIQDQVQDELRRVIG-DRM------------------------------------------------------VQVSDRKNLPFTDAVIHEIQ-RLASIVPTALPHKTSKDVTFQGYFIKK------GTTVFPLLTSVLHDANEWEKPHTFYPA------HFLDKDG---------KFVKREAFIPFSAG-----------RRICLGE-SLARMELFMFFTTLLQNFCFTPPPGVSKEELSLTPCGG--ITVGPV--------PHKLCAVPCSE----------------------------------------------------------------------- Oryzias_latipes_OlCYP2K30 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGVWDTLLPSLS--PSSLLGAGVLLLLVFLFCPHRTSSQKHRK-----------------------------EPPGPTPIPILGNLHQLDL----------------KRPDQTFMKFA------KKYGSVFTVYMGPKKTVVLTGYKTMKEALVNYA---EEFGEREAPTVAK-EAHLDCG---VVWANGASWREMRRFALSTLRDFGMGKRA-------CEDKIIPECHSLLKEIR-------------KFQGEAFDPTLIINSAVCNVICSMVYGTRFEYDDPDF----RTILSRTMKGIQLLGS---PGVQLHNLFPRIGRLFLSASKQINQIFTANKNYHLKLL---KETF-------TPHTCKSIADAFQLR--QQE-----------------------------------------EDGFPNSHFHDANILVTIMNLFTAGTETTAATLRWALLFMAKYPKIQDQVQEELSRVME-GRQ------------------------------------------------------VTVEDRQRLPFTDAVIHETQ-RKANIIPLSLLHRTSQDVTFKGFFIEK------GTTVIPVLTSVLYDENEWEKPNIFYPA------HFLSKDG---------KFLKRDAFMPFSAG-----------RRLCLGE-SLARMELFLFFSTLLQHFRIAPPLGVSEEELDLTPRPG--GTLSPQ--------PHKLCLVSLK------------------------------------------------------------------------ Oryzias_latipes_OlCYP2N.like1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWLCVWCQWCGLTGTLFFIFAVFFVLCLVK-QKDPPH-----------------------------FPPGPPALPVLGNIFSIDS----------------KQPHIYLTKLA------DVYGNVFCIRLGRHKTVFVTGWKTVKEALVTQA---DNFVDRPYSPMVTRIYGGNSA--GLFFSNGSVWKRQRRFAMTMLRTFGAAKSS-------TEQSICEESRHLLEAME-------------MEGGEPFDPVPLLNKAVSNIICQIVFGRRFDYSDTDF----QAMLTNLTDMAYLEGS---VWALLYDAFPALMKYLPGPHNSIFSSSKSLETTIRREINRHKQDL-------DPSNPRDYIDKFLMEERHNR-----------------------------------------KIHS---GFEEENLVLCCLDLFLAGSETTSKTLQWGLIYLITNPHIQDKVQAEMDRVVGHSRQ------------------------------------------------------PTTADRTNMPYTDAVIHEIQ-RMGNIVPLNGLRMAAKDTTLGGYIIPK------GTAVMPNLTSVLFDKTEWETPDNFNPE------HFLDADG---------KLLRKEAFLPFSAG-----------RRACLGE-GLARMELFLFFVTLFQRFHFSAAAGVELRTEGI---IG--ATRTPH--------PFQIIAKPR------------------------------------------------------------------------- Oryzias_latipes_OlCYP2N.like2 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDLFSSTIGLMLEWDLKSLLLFLSVFIITADYIKNR-RPLS-----------------------------FPPGPPGLPILGNIFTVDV----------------GRPHESFSKLA------AEYGDLYSLRFGQRWTVVLNGHKALKEALVTKG---DSVVDRPHLPLQDEIAKG-LG---VIFSNGANWTEQRRFALSTLRYFGFGKKS-------LEPVILNEFAHCAEELK-------------RFKGEPLDPHLIINNTVSNIICHLVFGHRFNYGDKKF----KKLMLLFDRALQIEAS---IWAQLYNSFTLIMRCLPGPHKTLQHIWREVQDFIGEELKEHKKSW-------DPSDARDYIDFYLTEIQKTK-----------------------------------------GQEGS--TFDEENLIMCVLDLFVAGSETTSTTLRWAFLYMAKYPEIQEKVQAEIHKVIGKSRP------------------------------------------------------PCMEDRAELPYTDAVIHEVQ-RIGNIVPLSLPHATNKDVQLGGFTIPK------GVLIIPNLTSVLFDEKEWETPHAFNPG------HFLNKDG---------KFVKRGAFIPFSAGEQQQSQHGSARKRLCLGE-NLARMELFLFFTSFMQHFSFSMPAGVEPVLDYR---AG--LTLAPK--------PYKICVQASSEK---------------------------------------------------------------------- Oryzias_latipes_OlCYP2N18 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWLDSFLLSFDLKALVLFIFLFLLIADWIK-HRKPAN-----------------------------FPPGPLGLPFVGNFLTIDG----------------KHPHIYFSKMA------ESYGNVFSVRLGSQATVFVSGYKMVKEALVTQA---ENFVDRPFSEIGGRFYEGNSN--GLFFSNGEKWKKQRRFALSTLRTFGLGKNT-------MEQSICEEIRHLQQQIE-------------NEKGGPFSPAGLFNNAVSNIICQLVMGKRFDYDDNNF----QVMMKYISEAVQLEGS---IWGILYESFPGLMKHLPGSHNKIFRNYKIVQDFLAQEIKIHKQDL-------DPNNPRDYIDSFIIEMEKHQ-----------------------------------------NSDL---GFNDANLAFCSLDLFVAGTETTSTTLMWALIYLIKHPDVQVKVQQEIDRVIGQNRL------------------------------------------------------PSMADRPNLPYTDAVVHEIQ-RIGNIVPLNGLRVAAKDTTLGGYFIPK------GTALMPMLTSVLFDKTEWETPDTFNPE------HFLDADG---------KFVKKEAFLPFSAG-----------KRVCLGE-GLARMELFLFLVGLLQKFSFSVPEGVELSTEGI---TG--TTRVPH--------PYKVYAKVR------------------------------------------------------------------------- Oryzias_latipes_OlCYP2N20 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWLLSFLTSLDLKTIFVFLFVFLLIADFLK-NRKAAN-----------------------------FPPGPPGLPFVGNLLSVDG----------------KHPHIYFTKLA------ETYGNVFSVRFGSETSVFVSGYKMVKEALVTQA---ENFVDRPYSPMATRFYQGPTN--GIFMSNGEKWKKQRRFALSTLRTFGLGKNT-------MEQCICEEIRHLQAEIE-------------SEKGQLFTPTGLFNNAVSNIVCQLVMGKRFDYNDHDF----HTMIKYLSEVLRLEGS---VWGLLYEAFPGLMKHLPGPHNEMFKDFDILRDFLDQEIKMHKKDL-------DRNNPRDYIDSFLIEMEKHQ-----------------------------------------NSDL---GFNEANLAFCSLDLFLAGTETTSTTLMWALIYLIKHPDVQVKVQQEIDRVIGQNRL------------------------------------------------------PSMADRPNLPYTDAVIHEIQ-RFGNIVPLNGLRVAAKDTTLGGYFIPK------GTALMPMLTSVLFDKTEWETPDTFNPE------HFLDADG---------KFVKKEAFLPFSAG-----------KRVCLGE-GLARMELFLFLVGLLQKFSFSVPEGVELSTEGI---TG--TTRVPH--------PYKVYAKVR------------------------------------------------------------------------- Oryzias_latipes_OlCYP2P12 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEGITSVLGLEWVDTWTILIFLFVFLLLSDFLA-NRRPKN-----------------------------FPPGPHSLPFIGDLHRIQP----------------ARLHVQFTEFA------EKYGNVFSLHLLGERTVILNGYKQVKEALVQQG---DDFVDRPTIPLFVDTIDN-KG---IVMSNGNSWKQQRRFALHTLRNFGLGKKT-------METYIQNECHYITQTFA-------------DKQGKPFDAQFLINNAVSNIICCLVFGERFEYSDQEY----QKILRNLNDLLILEGS---VSAMLYNMFPWLMKRLPGPHQKIFSLTRKIIDFVKIKINEHKGNF-------DPSAPEDYIDSFLIEMEKSQ-----------------------------------------DK-DS--GFDIDNMCICTMDLFLAGTETTTTTLYWGLLYMIYYPDIQEKVHAEIDAVIGSSRQ------------------------------------------------------PSMADKESMPYTDAVIHEIQ-RMGDIVPQGVFRQANRDTTLDKYTIPK------GTIIVPALHSVLHDESMWDNPHSFDPK------NFLDKDG---------KFCKREAFNPFGAG-----------KRVCLGE-QLARMELFLFFTSLFQRFSFSAPTGEQLSLESR---MG--ATRCPK--------PFRVIAAPR------------------------------------------------------------------------- Oryzias_latipes_OlCYP2P13 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEAITAVLGFEWIDSRSLLIFLFVFLLLSDYLA-NRRPKN-----------------------------FPPGPHSLPFIGDLHRINP----------------SRLHLQLTEFA------EKYGNVFSLHLFGERAVILNGHKHVKEALVQRG---DDFVDRPSIPLFEQFYSN-KG---IVVSNGYPWKQQRRFALHTLRNFGLGKKT-------MEKYMQEECRYLTEAFG-------------EYKVKPFNAQALINNAVSNIICCLVFGERYEYSDKQY----QQILQDINEIMILQGG---FAAQLFNSFPWLMKKLPGPHQKILTLLAKLIDFAKVKISEHKENL-------DPSSPKDYIDSFLIEMAQNE-----------------------------------------NQ-ES--SFDISNLCMCTLDLFIAGTETTTTTLHWGLLYMIYYADIQEKVQAEIDAVIGSSRQ------------------------------------------------------PSMADKENMPYTDAVIHEIQ-RMGNILPLGVLRMASKDTTLDKYTIPK------GTMIIPTLNSVLHDESMWETPHSFNPK------HFLDKDG---------KFRKREAFNPFGAG-----------KRVCLGE-QLARMELFLFFTSLLQRFSFSAPAGEQPSLENR---MG--ATRCPK--------PYRLCAVPR------------------------------------------------------------------------- Oryzias_latipes_OlCYP2P15 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEAIYSVLGLEWLDWTSALLFLFVFLLLSDVLT-NRKPKN-----------------------------FPPGPRSLPFIGDLHRIRP----------------TILHLQFKEFA------AKYGNVFSLNIFGGKTVVLNGTKLLKEALIQKG---DDFVDRPQIPLFSDLIEN-KG---IVMTNGIQWKHQRRFALHTLRNFGLGKKT-------MEKYIQEECHYITQAFA-------------EHQGKPFDAQPLLNSAVSNIICCLVFGERFEYSDKEY----QQILQDLTEVVKLQGS---FSALAYNVFPWLMKRFPGPLQKLFTLVDKIMDFVKIKIEEHKENL-------DPACPKDYIDSFLIEMEKNQ-----------------------------------------GE-DF--GFDIKNLCACTLDLFGAGSETTTTTLYWGLLFMIHYPDIQEEVHAEIDAVIGSSRQ------------------------------------------------------PSMADKENMPYTDAVIHEIQ-RMGDIVPIGVARMASRDTMLDNYTIPK------GTMIMPALHTVLHDESVWETPHSFNPQ------HFLNQDG---------TFKKREAFFPFGAG-----------KRVCLGE-QLARMELFLFFTSFLQRFSFSTAGGEKPPLEGR---MG--TIRSPK--------SYRLCAVPR------------------------------------------------------------------------- Oryzias_latipes_OlCYP2U1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVSSSFGLIWSSVLSLSNLLTSLLFLLVYYLVRFYQKQRTIYKN----------------------------IPPGPKPWPVVGNFGNFFVPPSVRTKIAGQPNSTNAIEIEALRQQA------TVFGNIHSLFIGGQLIVVLHGFHLIRDALLNQP---EVFSDRPDIPLVT-ILTKRKG--IVFAPYGPVWRKQRKFCHTTLRSFGLGKLS-------LEPCIQRGLAGVKAELLRLNE---------ERGSAGVDPATLIGNSVSNVICSLILGQCFHHHDVEF----RTMIRLMEHGLKICIN---SPAVLINIFPLLYYLPFGVFKELRQVERDITAFLKRIIAKHRDTL-------DPDNPRDLTDMYLIEMLTQQA----------------------------------------AGE-EDSSFTDDYLFYVIGDLFIAGTDTTTNSILWFLLYMILHPDVQDKAQAEIDGVVGKHRV------------------------------------------------------PSVTDKGSLPFTEATIMEVQ-RLHSVVPLAIPHMTSETTVFRGYTIPK------GTVIFPNLWSVHRDPTLWEDADSFNPS------RFLDNEG---------NLLRKEYFIPFGIG-----------RRVCMGE-QLAKMELFLTVTTLLQAFKFRHPEGNPPPTVKER--FG--LTMAPC--------PFSVCVTPRGGPNLNP------------------------------------------------------------------ Oryzias_latipes_OlCYP2X14 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFVSLILLWLCICILFLQLKPRRPKN-----------------------------FPPGPPVLPMLGNLLHLSL----------------DNPLKDFDRLR------NSYGNVYSLFLGPKPAVIINGFKAMKEAMVIKA---TDFAGRPQDLFVN-DVSKRKG--VILADYGESWRDHRRFALMTLRNFGLGKKS-------MEERISEEIQHTIKTLE-------------NNIGKLFSPQIMFHNAASNIICQVLFGKRFEYDDEII----KTIVQCFTRNSKIANG---PWAMIYDSIP-LIRKLPLPFREAFKNAEICVDVGTHLVNEHKETR-------IPGKPRDFVDCYLDEMEK-R-----------------------------------------GDDSS---FSEDQLIIYALDLHFAGTDTTSNTLLTGFFYLINYPHIQDKCQQEIDRVLEEKQQ------------------------------------------------------VTFEDRHNMPYMQAVIHEVQ-RIANTVPLSVFHSTTKETELMGYTIPK------GTMIIQNMGSVLREDGQWKFPHDFNPE------NFLNEKG---------EFVKPEAFMPFSAG-----------PRMCLGE-GLARMELFIIMVTLLRKFKFTWPEDAGEPDFTP--VYG--VTLTPK--------PYFMK----VQLRSKP------------------------------------------------------------------ Oryzias_latipes_OlCYP2X20 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFVSIFLLWLCFFFILFQFKLWRPKN-----------------------------FPPGPLSLPVLGNLLHLNL----------------KNPLVDFEKMK------ESYGNVYSFFIGSRPAVVVNGLQAMKEAIMIKA---TDFSGRPQDMFVS-DLTQRKG--VILVDYGSVWRDHRRFALMTLRNFGLGKIS-------MEERIHEEIQFTISKLE-------------ENIGKTLSPKFMFHNAASNIICKVLFNTRYDYEDGKI----SEIVQGFVEMLQIANG---PWAMMYDAFP-WIRSFPLPFNKAFRNMENFLNLAKRLVNEHKMSR-------VAGEPRDFVDSYLDELEK--------------------------------------------NKKD---FSEQQLLRMTFDLYIAGTDTTSNTMLAGFLYLMVYPHIQEKCQREIDQMLERKDR------------------------------------------------------VSFEDRHKMPYMQAVIHEVQ-RFANIVPLSVFHCTTKDSELSGYTIPK------GTLIIQNMVSVLREEGQWKFPHEFNPE------NFLNDQG---------EFIKPEAFMPFSAG-----------PRMCLGE-GLARMELFIIMVTLLRKFKFTWPEDAGQPDLSP--VFG--ATLTPK--------PYCMK----VQLRSEQQSC--------------------------------------------------------------- Oryzias_latipes_OlCYP2Y6a -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDLSTSLILVVLTTVLLWLLNRRNS---RKQH-----------------------------LPPGPPALPLIGNLLQLDK----------------KRPFRTIVELS------KTHGPVMTIYMGWQRAVALVGYDAVKEALVDQA---DDFVGRAPLPFLY-RATRGYG---IGISNGERWRQLRRFALTTLRDFGMGRKG-------MEQWIQEESRHIRAKIN-------------TFKGKPFDPTFILSCTVSNVICCLVYGERFNYDDKQF----LELLQIISEVPRFNSS---PMGAMYNLFPWLMERLPGRQHTIFGYIEDIRKFAKNKIQEHKDKL-------DPSSPRDFIDCFLLRMDQEK-----------------------------------------D--NPTSEFHYENLLAMVLNLFLAGTETTSSTIRYALSVLIKHPKIQEKMQEEIDSVIGRERC------------------------------------------------------PSMEERKSLPFTDAVIHEVQ-RFMDLTPFSLPHYSLKDISFRGYTIPK------DTMIFPMLHSVLREDKLWSSPWSFNPQ------NFLDQNG---------NFKKNPGFVPFSAG-----------KRACVGE-SLARMELFLFIVSFLQDFTFSAPNGP--DSINLVPEYSS-LANLPR--------RYELIATPR------------------------------------------------------------------------- Oryzias_latipes_OlCYP2Y6b -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDLSTSLILVVLTTVLLWLLNRRNS---RKQH-----------------------------LPPGPPALPLIGNLLQLDK----------------KGPSRTIVELS------KTYGPVMTIYMGWQRAMALVGYDAVKEALVDQA---DDFVGRAPLPFFY-RASRGYG---IGISNGERWRQLRRFTLTTLRDFGMGRKG-------MEQWIQEESRHLRAHIM-------------SFKGKPFDPMFKLSCAVSNVICCFVYGERFNYDDKQF----LELLKMISEILDFNGG---PIGAMYNLCPWLLEHLPGHQHTVFGYIEVTRNYAKKKIQEHKDTL-------DPSFPRDFIDRFLIHMDQEK-----------------------------------------D--NPTSEFHYENLLAMVQNLFLAGTETTSSTIRYALSVLIKHPKIQEKMQEEIDSVIGRERC------------------------------------------------------PSMEDRKSLPFTDAVIHEVQ-RFMDLAPFSLPHYSLKDISFRG????K------DTMIFPMLHSVLREDKLWSSPWSFNPQ------NFLDQNG---------NFKKNPGFVPFSAG-----------KRACVGE-SLARMELFVFIVSLLQNFTFSAPNGP--DSINLDPEYSG-LTNQHC--------RYELIATPR------------------------------------------------------------------------- Oryzias_latipes_OlCYP2Z5 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWLCVWCQWCGLTGTLFFIFAVFFVLCLVK-QKDPPH-----------------------------FPPGPPALPVLGNIFSIDS----------------KQPHIYLTKLA------DVYGNVFCIRLGRHKTVFVTGWKTVKEALVTQA---DNFVDRPYSPMVTRIYGGNSA--GLFFSNGSVWKRQRRFAMTMLRTFGAAKSS-------TEQSICEESRHLLEAME-------------MEGGEPFDPVPLLNKAVSNIICQIVFGRRFDYSDTDF----QAMLTNLTDMAYLEGS---VWALLYDAFPALMKYLPGPHNSIFSSSKSLETTIRREINRHKQDL-------DPSNPRDYIDKFLMEERHNR-----------------------------------------KIHS---GFEEENLVLCCLDLFLAGSETTSKTLQWGLIYLITNPHIQDKVQAEMDRVVGHSRQ------------------------------------------------------PTTADRTNMPYTDAVIHEIQ-RMGNIVPLNGLRMAAKDTTLGGYIIPK------GTAVMPNLTSVLFDKTEWETPDNFNPE------HFLDADG---------KLLRKEAFLPFSAG--------------------------VLVWARALPGWSSSCFSSLYFR--GF---I----FRRQQ--------EWSCVQKE-------------------------------------------------------------------------- Oryzias_latipes_OlCYP3A38 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGNFLYFSAETWTLLVAFITLLLVYAYWPYGTFKRL----------------------------GIPGPKP-VPFFGTMLAYRKG------------------FPIFDEEC-----HKKYGKTWGIYDGRQPVLCITDPATIKAVLVKEC-----YSLFTNRR--NFHLNGPMYDSVFNAE-DDQWKRIRSVLSPSFTSGRLKEMFD------IMKHHSANLVNSMKKKAD--------------KDEPLNLKDHFGPYSMDVVTSTAFSVDIDSLNNPS----DPFVTNIKKMLKFDFLNPL-FLLVAFFPFLGPIMEKMELSFFPASAFDFFYSALQKIKSDHK-------NNKQKSRIDFLQLMIDSQKNN--------------------------------------QNG---LQ-DKGLSDHEILSQAMIFIFAGYETTSSSLTFLAYNLATNPEVMKKLQKEIDATFPNKA------------------------------------------------------PIQYAPLLEMEYLDSVVNESL-RLYPIAARLERVAKATVEVN-GLVIPK------DMVVMVPTWPIQRDPELWPEPEKFKPE------RFSKETK---------ETFDPYTYMPFGAGP-----------RNCIGM-RFALVSMKLALVEILQQYSFSVCKETEIP-----FELDIQGLIAP-------KRPIFLKLVPRSAC---------------------------------------------------------------------- Oryzias_latipes_OlCYP3A40 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGNFLYFSAETWTLLVAFITLLLVYAYWPYGTFKRL----------------------------GIPGPKP-VPFFGTMLAYRKG------------------FFNFDDEC-----RKKYGKTWGIYDGRQPVLCITDPATIKAVLVKEC-----YSLFTNRR--NFRLNGPLYDAVSIAE-DDQWKRIRSVLSPSFTSGRLKEMFD------IMKHHSANLIQSMKKKVD--------------KDEPLEMKEYFGPYSMDVVTSTAFSVDIDSLNNPS----DPFVTNIKKMLKFDFLNPL-FLAVAFFPFLGPILEKFEFSLFPSSVMDFFFAALRKIKANHE-------NNKQKSRIDFLQLMIDSQKNN--------------------------------------QNG---LQ-DKGLSDHEILSQAMIFIFAGYETTSSSLTFLAYNLATNPEVMKKLQKEIDATFPNKA------------------------------------------------------PVQYVPLMEMEYLDCVVNESL-RLYPIAARLERVAKATVEVN-GLVIPK------DMVVMVPTWPLHRDPELWPEPEKFKPE------RFSKENK---------DTFDPYTYMPFGAGP-----------RNCIGM-RFALVMMKLAVVEILQTYDFSVCKETEVP-----FEMDVQGFLAP-------KRPIQLKLTPRSASSS-------------------------------------------------------------------- Oryzias_latipes_OlCYP3A40.like --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFSATTWTLLALFFTVLLLYGVWPYRVFRKL----------------------------GISGPMP-LPFVGNVLQMGRD------------------ILSFDRQC-----LDKYGDVWGVFEGRQPMLMVANPELVKAVMVKEC-----YSAFTNRR-NFFPEDGPLADGVAVVK-DEKWKRIRSSLTPCFTSGRLKQVYP------LVARYAENLVKKLGRMNS---------------DEPIDVRQFVAPYSMDVVASTSFSVDTDCINNPD----DPVNVQAQKATNFNFWP---VILQTMIPFGDLLLKLLKFETLPRSNVDFFYDLIKRLRDQHKA--------GKLTRPDFLQVLIDSEIPQEHV-----------------------------------KN----EQPSKGLTEHEVLSQAFGFVLAGYETMSNTLCFILYNLATNPDAMCTLQKEIDSNLQNDG------------------------------------------------------SFSYEELSGLEYLDQVLCESM-RFFSPTPRLDRECKKTIEIH-GVTIPK------GTLVAIPVSLLHMDPRFWSSPEIFRPE------RFSKENA---------SELNPYAYMPFGLGP-----------RNCVGM-RFAVLVMKMVIVRLLQSYSLETCKDTLIP-----MQYDWQ--FQP-------IKPIKLKFVPRKQ----------------------------------------------------------------------- Oryzias_latipes_OlCYP3A56.like ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFFTLLSPTTWTLLALLFALLWLYGTWPHSVFKNL----------------------------NIPGPKP-LPFVGTIFGVRKG------------------LFAFDSEC-----QAKYGDVWGLYDGRSPVLMVADPEMIKTIMVKEC-----YSVFTNRR-D-TEIPGPFEDGITVVK-DDRWKRIRSTISPCFTSGRLKQVFP------IVASYADRLLKKLEQTNL---------------DEPIHVKQFVAPYSLDTVASASFSVEMDSINNSE----DPVNVHIQKLFNINFWP---FILLMICPFAGRLLNSLNIGMLPKAESDFFLNIIKKFKDQHKA--------GESTRQDFLQVMVQSEIPENEI-----------------------------------KNE--QEQPSKGLTEPEIVAQAFTFILGGYETTSTTLSFILYNLATNPHAMHTLQKEIDANLQKNA------------------------------------------------------SFSYEELNDLHYLDQVILESM-RVLPTAPRLERGCKKTVEIQ-GFTIPE------GTVVGIPVMNLHKDPRYWSSPELFRPE------RFSKENE---------GELNPYAYMPFGLGP-----------RNCVGM-RYAILVMKMVIVRLLQNYTLETCKDTLIP-----LQFDWK--FQP-------LKPIKLKFVPRKQ----------------------------------------------------------------------- Oryzias_latipes_OlCYP3B5 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFLSCSLIIHVDAVQVTMLFLFSATTWTLLALIFTILLLFGIWPFRIFQNM----------------------------GISGPMP-MPYVGNLLQQGKG------------------FFEFDHEC-----QTKYGDVWGVFEGRQPILMVADPEIIKTVMVKEC-----YSAFTNRR-NFFEGDGPLTEAVASAK-DEKWKRIRSSLSPCFTSGRLKQVFS------IVSRYADRLVEKLGETYL---------------NKAIDIRQFVAPYTLDVVASASFSVDPDCINNPD----DPINVQAQKATRFNFLP---TILQSIIPFGGRLLKLFKIETLPSANVEFFIDIIRNLKDQHKT--------GKMNRPDFLQVLIESEMPDAEI-----------------------------------KNS--QQQPSKGLTETEILSQALGFIVGGYDTTSTALSYIFYCLATNTDAMHTLQKEIDSNLQKNS------------------------------------------------------SISYEDLNGLEYLDQVINESL-RLYPVAPRLDRECKMTVETQ-GFTVPE------GMIVGIPVYLLHKDPRFWSSPELFRPERLFGLCRFSKENE---------GELNPYAYMPFGLGP-----------RNCVGM-RFAVLMMKMIIVRLLQRYSVETCKYTLIP-----MQFNWM--FQP-------IKPVKLKFVPK------------------------------------------------------------------------- Oryzias_latipes_OlCYP4T12 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFAAGLTEALFGFQLTWLHIHVAFG---ALCIIVIVHKLTLLTATRKSLLRDVE----------------------------AFPGPPG-NWLFGHVLQLKQD------------GTDLERGLKWGEQY-----PYA---FPMWFGPSVCFLNIHHPDYAKTILTTTE----PKDDLAYRFIES-----WIGNGLLVSK-GQKWFRHRRLLTPGFHYDVLKHYVN------LMSESAQVMLDKWESYANT--------------SETFELFEHVSLMTLDSILKCAFSHNSNCQREGETNKYIKAVYELSDLISFRMRTFPYHSDLIFYLSPHGFRHRRACKVAHSHTQEVIRKRKEALKEETE-------SSR---KRNLDFLDILLFAKDENQ---------------------------------------------QGLSDEDIRAEVDTFMFEGHDTTASGISFILYCLASHPEHQKICRNEVMEALDGKD------------------------------------------------------TIEWEDLNKIPYTTMCIKESL-RLYPPVPGISRKLTKPITFFDGRTLPA------GFKVGTSVFGIHRNATVWENPEVFDPL------RFLPENV---------SKRSPHAFVPFSAGA-----------RNCIGQ-NFAMNEMKVVIAMTLKKYQLIEEPSLK-------PRIIPRLVLRSL-------NGIHIKIKPVEAQK--------------------------------------------------------------------- Oryzias_latipes_OlCYP4V2 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSLLLGGYSLSFVGVSIFIAALTYITYKLLSDHLQKWFEMK----------------------------PIPGLEKTYPIIGNSLYFKANA-----------GEFFNQILEFCDTF-----RDEP-LFKIWLG-PIPFVVLFHSETVEKVLSNPV---HLDKSFAYTFLHP-----WLGTGLLTST-GKKWKQRRRILTPTFHFSILTDFLE------VMNEQAELLVEKLDKLAGK---------------GQFNCFSHVTLCALDIICETAMGKKIYAQSNSE-SEYVKSVYKMSDIISRRQRAPWFWPDFLYYFFGEGKEHDKTLKILHSFTKKVIYERSESLSHTESDGE-----SDRGSRKRKAFLDMLLNTTDENG---------------------------------------------NKLSHQDIQEEVDTFMFEGHDTTAASMNWALHLLGSHPEVQRKAQEELQEVFGASDR-----------------------------------------------------PATTEDLKKLKYLECVIKEAL-RLFPSVPFFARRLGKDCHIN-GFMVPK------GANAIIITYTLHRDPRYFPEPEEFRPE------RFLPENA---------AGRPPYAYVPFSAGL-----------RNCIGQ-RFALMEEKVVLSSILRKFNVEACQVRED------LRPVGELILRPE-------RGIEIKLEKRGCPASAN------------------------------------------------------------------ Takifugu_rubripes_TrCYP1A1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVLMVLPLIGSVSVS------EVLVALTTACLVYLMVRYFYTEIP--------------------------AGLRRLPGPTPLPIMGNVLEIG?-----------------??F?SLTAMS------KRYGDVFQIQIGTRPVIVLSGIETVRQALVKQG---EEFSSRPDLYSFRFINEGKSL--SFSTDQAGVWRARRKLAYNALRSFSTLQGTTPEYSCMLEEHICKEGEYLVNRLSSVLQA-----------DGRFEPFPHIVVSVGNVICGMCFGRRYDHDDQEL----VSLVNLSNEFGKVVSSG--NPADFIPALRFLLSST---MKSFVDLNTRFTTFVQKIVNEHYATF-------DKENIRDITDSLIDHCEDRK-----------------------------------------LDENSNIQVSDEKIVGIVNDLFGAGFDTVSTALSWSIMYLVTYPDVQERLYQELKSNVDQNRK------------------------------------------------------PRLSDKPNLPLLEAFILELF-RHSSFLPFTIPHCTSKDTSLNGYFIPK------DTCVFINQWQINHDPEQWEDPSSFNPD------RFLSADGT-EV-----NKAEGEKVTTFGMG-----------KRRCIGE-IIARNEVYLFLAILIQRLQFLPIPGETVDMTPE---YG--LTMKHK--------DCRLKARMRTRDEQ-------------------------------------------------------------------- Takifugu_rubripes_TrCYP1B1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKVIQEEVSP--------EAGALLLACATLLVSLQLWRWRRR--------------------------RPGGCPPGPRAWPIIGNAAQLGH-----------------APHLYFTRMA------QRFGNVFQIKLGSRTVVVLNGD-AIKQALVRKG---LEFAGRPDFTSFKYISNGHSL--AFGT-VTDWWKSHRRVAQSTVRMFSTGNLQTKKT---FERHLTCEVRELLHLFLGKTKE-----------LQYFQPMNYLVVSTANVISAVCFGKRYSYEDEEF----QQVVGRNDQFTRTVGAG--SIVDVMPWLQYFPNPVKSIFDNFKRLNKEFSDFIRDKVTEHRKSI-------RPSSVRDMTDAFIVSLD-K------------------------------------------LSEKTGVPLWKDYVIPTVGDVFGASQDTLSTALQWIFLVLVRYPDMQQRLQEEVDLVVGRQRL------------------------------------------------------PCIEDQQQLPWVMAFIYEVM-RFTSFVPLTIPHSTTTDTTIMGYTIPK------NTIIFINQWSVNHDPTIWSHPETFDPN------RFLNPSG--SL-----NKDLTSRMLIFSMG-----------KRRCIGE-ELSKLHLFLFTALIGHQCHITDDPAKPTTMDYN---YG--LTLKPR--------GFYVALTLRGDMRLLDEAASRPPAEEPGRGPLADP----------------------------------------------- Takifugu_rubripes_TrCYP2AD.like --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MILQKIFAYMDFSSWVLLIFLVLLITDVIR-NWTPHN-----------------------------FPPGPWAMPFVGNIFTGV-------------------DFRTIEKLS------QKYGPVFSLRRGNTRTVFINGYKMVKEALVSQL---DSFEDRPVVPLFHVVFKGI----GIALSNGYMWKKQRKFAHTHLRYFGEGQKL-------LENHIQMESKFMCEAFK-------------DEQGKPFDPQYTITNAVGNIISALVFGHRFEYSDASF----RRILELDNEAVVLAGS---ARTQLYDSFPSLMKHLPGPHQTVHANYGKITDFLKKEVDKHMEEW-------NPEDPRDYVDTYLSEMEKMN-----------------------------------------QDPQG--GFNVETLLICILDLIEAGTESAATTLRWGLVFILNYPDVQEKVQEEIDRVIGQSRQ------------------------------------------------------PAMADRPNMPYTDAVIHEIQ-RFANVVPAGFPKMATKDTTVGGYFIPK------GLAITTMLSSVLFDKNEWETPDVSTPI------ISWTQRV---------DSAKEMPSFHFLQV-----------SACASGK-TWPK------WSSSFSSPPSCSISISLLFLDKC---PA--WRVSWA--------SPTLHSHSE------------------------------------------------------------------------- Takifugu_rubripes_TrCYP2K1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGIVDLFLQASS--SVSLLGALALLLFVYFISSVSFSSKKDRK-----------------------------CPPGPKPLPILGNLLQFDL----------------KRPYNTLMKLS------KTYGSVFTVYLGPKKVVVLAGYKTVKEALIDHA---EEFGERDPIMLVQ-NANHEHG---VLWSNGESWKEMRRFALTNLRDFGMGKKA-------CENKIIEECSYLMEELK-------------KWKGEPFDTTHPINYAVSNIICSMVYGNRFEYDDPEF----TSLVDRTNTLIQISGS---PSVLVYDLFPWIGPLVN-NKKLFQSLFAANKKQNLQLFAAAKEML-------NPQMCRSFVDSFLARQQILE-----------------------------------------KSGT-NVHFHDENLMSTVMNLFNAGTDTTATTLRWGLLLMAKYPLIQDQVQEELRRVIG-SRQ------------------------------------------------------VQVEDRKSLPFTDAVIHETQ-RLANIVPMALPHKTSQDVTLQGFFIEK------GTTVYPLLTSVLYDETEWEKPLNFYPA------HFLDKDG---------KFVKREAFLPFSAG-----------RRICLGE-GLAKMELFIFFSTLLQHFRFRPPPGVSEDHLDLTPRVG--LTLNPS--------AHKLCAVSCL------------------------------------------------------------------------ Takifugu_rubripes_TrCYP2K.like1 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSLQDFLLSLG--PSTLMGSVALLLLLCLVSR-SF-GRATRR-----------------------------EPPGPRALPLLGNLLQLDL----------------SRPHQTLYQLS------KKYGPVFKVHFGPRKVVVLAGHKTVKEALVGNA---EQFGDRDISPIFY-DMNQGHG---ILFSNGETWKEMRRFALSTLRDFGMGKRM-------IEDKIAEECNYLIQKFE-------------DHEGRAFDTSRLANYATSNIISSIVYGSRFDYDDPRF----INMVNRANEVIRLTGS---APIQLYNIFPGLANWIK-NRQLLLKQVAMNFRDMTDLIQQLKDTL-------NPGVCRGFVDCFLLRKQKAV-----------------------------------------DSGVIDSLYNEKNLLYSLSNLFGAGTDTTATTLRWGLLLMAKYPRIQDQVQQELSMVVG-NRR------------------------------------------------------VCVEDRKNLPYVDAVIHEIQ-RLGNIAPMAVPHKTARDVEFRGYFIEKVKYFSEGTTVFPLLTSVLYDENEWETPHTFNPS------HFLDKDG---------KFIKRDAFMPFSAG-----------RRLCLGE-GLAKMEIFLFFTSLLQQFRFTPPPGVGEDELDLTPALG--FTLSPS--------PHKLCAIPRQ------------------------------------------------------------------------ Takifugu_rubripes_TrCYP2K.like2 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIEDLFESS--TSGFLMVAIVSLLLLQLCFS-FI-SREKRK-----------------------------DLPGPEALPLLGNLHQLDL----------------KRLDCHLVQLS------QKYGPIFRVYLASKKVVVLAGYTAVKQALVNQA---EDFGEREIFPIFH-DFNKGNG---ILFTNGDQWKEMRRFALMTLKDFGMGKKI-------EEK-IIKECQYLIEAFE-------------QHQGEAFSNAQVISYATSNIISAIMYGRRFDYKDPTF----QAMIERDHEVIHLTGS---PSIQIYNIFPWLGPFLK-TWRYIMKKVEINIESTRRIIGEMKETR-------NPGTCRCFVDAFLIHKENQE-----------------------------------------ESDVNAHYYHEDNLLHCAMNLFGAGTDTTATTLQWGLLYITKYPHIQDGVQEELRRVVG-NRQ------------------------------------------------------VRVEDRKNLPYMEAVIHETQ-RMANIVPMSLPHRTSRDRHLLGSICPQ------GTMVIPLLTSVLYDESQWEKPHTFNPA------HFLDDEG---------RFVRRDAFMPFSAG-----------RRMCLGE-GLARMELFLFFASLLQHFRFKPAPGVSEDSLDLTPVVG--ITLNPL--------THKLRAISRF------------------------------------------------------------------------ Takifugu_rubripes_TrCYP2N.like --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MWLWDLVLWLRLTGFLLPVLIVLLIIMYSLRQKDPPN-----------------------------FPPGPPALPLLGNIFNIEA----------------KQPHLYLTKLA------DVYGSVFCIRLGRHKTVFVSGWKMVKEAIVTQA---DSFVDRPYSPMATRIYSGNSA--GLFFSNGHVWRKQRRFAMATLRSFGLANGS-------MELSICEESRHLQEAME-------------RQKGEPFDPVPLLNNAVANIICQIVFGRRFDYTDHMF----QRMLHHLTEMAYLEGS---IWALLYDSFPALMKHLPGPHNGIFSSSSSLQGFIWREIQRHKSDL-------DPSNPRDYIDAFLIEE-GNG-----------------------------------------NNQL---GFEERNLVLCCLDLFLAGSETTSKTLQWGLIYLIRNPHIQEKVQVEIDRTIGRTRQ------------------------------------------------------PTMADRPNLPYTDAVIHEIQ-RMGNIVPLNGLRMTTKDTTLGGYLLPK------GTSVMPNLTSVLFDKNEWETPDTFNPE------HFLDAEG---------KFVRREAFLPFSAG-----------RRACLGE-GLARMELLLFFVSLCQRFHFSTLDRVELSTEGI---TG--ATRTPY--------PFKIYAQVR------------------------------------------------------------------------- Takifugu_rubripes_TrCYP2P.like -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEAILSTLGLEWMDGRTILIFLLVFVLLADYIK-NRVPSN-----------------------------FPPGPWPLPLIGDLHRINP----------------SRLHLQFAEFA------GKYGNIFSLRLFGGRVVVLNGYKTVREALVEKG---ENFVDRPLIPLFEAFAGN-RG---LVISNGNPWKHQRRFALHTLRNFGIGKKS-------LEPSIQQECHYLAEAFA-------------QHKGEPFYAKALIHNAVSNIICCLVFGERFEYSDKQY----HAILKSFDRIIQLQGH---FIVQVYNTFPWLLKWLPGTHQTIFSEIKTVINFVDLKIQEHKRNF-------DPSSLRDYIDCFLAEMGEKE-----------------------------------------DV-ES--GFDMKNLSICTMDLFGAGTETTTTTLQWGLLYMIYYPHIQEKVYAEISAVIGSSRE------------------------------------------------------PSITDRDNMPYTNAVIHEMQ-RMANIIPLNVVHMASSDTTIGNYTIPK------GTIIMPTLNSVLHDESMWETPHSFNPQ------HFLDQDG---------KFRKREAFLPFSAG-----------KRVCLGE-QLARMELFLFFTSLLQRFSFSMADGEQPSLDFQ---LG--GARFPK--------PYRLRAILR------------------------------------------------------------------------- Takifugu_rubripes_TrCYP2U1 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMSLSWLQS--LS-SSILTLVIMIILHHLFKCYQKRHG-FAN----------------------------IPPGPKPWPVVGNFGGFLVPSAIRKRFGSKAEGPAKNAAAVLTELA------KVYGNVYSIYVGSQLVVVLNGYKVVRDALSNHP---DVFSDRPDIPAIS-IMTKRKG--IVFAPYGPLWQKHRRFCLSTLRNFGLGRLG-------LEPCIVEGLTNIKTELLRLEE---------ESGGAGVDPAPVISNAVSNVICSLVLGHRFNHDDQEF----RSMLRLMDRGLEICVN---SPAVLINVFPLLYHLPFGVFRELRQVERDITAFLKRFIANHQETL-------DPNNPRDLTDMYLKEISARRE----------------------------------------AGD-VDSGFTEDYLFYIIGDLFIAGTDTTANSVLWVILYMASYPDIQDKVQAEIDGVVGPLRT------------------------------------------------------PSLSDKGKLPFTEAAIMEVQ-RLTTVVPLAIPHMTSETIEFMGYTIPK------GTVVLPNLWSVHRDPTEWDDPDSFDPT------RFLDEDG---------TLLRKECFIPFGIG-----------RRVCMGA-QLAKMELFLTVTNLLQTFHFRLPEGAPRPPLQGR--FG--LTLAPC--------PYTVCINPR------------------------------------------------------------------------- Takifugu_rubripes_TrCYP2X.like -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVTSVILLCLGVVVLVLLLRSQRPKN-----------------------------FPPGPPVLPLLGSILELAL----------------DNPLQDFERLR------KKYGNVYSLFLGTRPAVVISGLKNIKEALVTKG---SDFSGRPQDMFIN-DAIKTNG--VIMQDYNLVWKEHRRFALTTMRNFGMGKTS-------MEDRIHGEIEYIVNTLE-------------KNNGKTLSPHLMFHNAASNIICQVLFGTRYEYDDHFI----REIVRCFTENAKISNG---PWAMLYDSIP-LVRYLPLPFKNAFKNVETAENLVKDLFVEHKKTR-------MSGDPRDFVDCYFDELDKRG-----------------------------------------KDRSS---FSENMLTMYALDLHFAGTDTTSNTLLTGFLYLMNYPHIQERCHQEIDKVLQDNET------------------------------------------------------VTYDARNQMPYMQAVIHEVQ-RVANTVPLSVFHCTTKDTEFMGYSIPK------GTLIIPHLASVLKEEGQWKFPNEFNPD------NFLNDDG---------EFVKPEAFMPFSTG-----------PRVCLGE-GLARMELFLIIVTLLHKFQFIWPEDAGEPDYTP--IFG--ATQTPK--------PYRMK----IQLRK-------------------------------------------------------------------- Takifugu_rubripes_TrCYP2Y.like -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEFSVTLILAGLVLAFFWFILQK-----RKYN-----------------------------LPPGPTTLPLVGNLPQLDK----------------KQPFKSFTELS------KSYGPVMTLYLGWQRTVVLTGYEVVKEALVDQA---EDFTGRGPLPFLL-KATNGYG---LGISNGERWRQLRRFTLSTLRDFGMGRKG-------MEEWIQEESKHLTARIK-------------TLKVKPFDPTFLLGCTVSNVICCMVFGERFSYDDKQF----LELLRVIAEVLRFNSS---FLGQMYNVFPWILEHLPGPQHTMFSHVNFLREFIKKKIQEHKESL-------DPSSPRDYIDTFLIRMEQEK-----------------------------------------N--LPNTEFHYENLVSTVLNLFLAGTETTSSTLRYALGVLIKHPNVQEEMQREIDNVVRQDQC------------------------------------------------------PKMEDRKSLPFTDAVIHEVQ-RFLDIVPFGLPHYALKDITFRGYSIPK------GTVIIPLLHSVLKGD-QWETPWAFNPK------HFLDQNG---------SFKKNSAFLPFSAG-----------KRSCVGE-SLARMELFIFLVTLLKDFTFSCIEGP--DSISLNPQYSG-FANLPR--------NYEIVATLR------------------------------------------------------------------------- Takifugu_rubripes_TrCYP2Z.like ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGLIVSVFGSHADWSISTLLLFTAVFILMVNWIRNR-RPPS-----------------------------FPPGPWTLPVVGNMHNLAH----------------HRMHLNLMELA------ETYGNVFSIQLGQEWMVVLNGPTILKEALVNQG---DSVADRPNLQLIIDSCHG-LG---LGFSSGHLWKQQRQFAISTLRYFGSGSKS-------LEPVVLEEFAHCAKQFS-------------EFKGKPFAPQLMFYNIVTNIICSLVFGHRFEYGDKNF----EKLMNSFGRCLQIEAS---VCAQLYNSFPRLMGCLPGPHQTVKRIYQNIRDFIREEMKEHKKGL-------DPSTPRDYIDCYLNKIKKSN-----------------------------------------LEPHN--TFHEENLVICVWDLFLAGTDTTTCTLRWLFLFMAKYPEMQEKVQAEIDEVIGQSRR------------------------------------------------------ATMDDCVNMPYTNAVIHESL-RMGNVVPLSLLHATGRDIQLEGYTIPK------GTTVIANLTSALFDKNEWETPFAFNPG------HFLDEEG---------RFRKRTAFLPFSAG-----------RRLCLGE-NLARMMLFLFFTSFMQDFTISFPAGVSPAMEYHH--FG--VTLAPH--------PFDICAVSR------------------------------------------------------------------------- Takifugu_rubripes_TrCYP3A27 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFVFMCFSATTWTILVLFSTLLLLYGIWPYRLFRKN----------------------------GIPGPMP-LPFIGTMWNLLKG------------------NMVFDREC-----QSKYGDVWGVFEGRTPVLMVSDPGMIKTILVKEC-----YSVFTNHR-EIFS--GPLETSVFSAK-DETWKRMRTSISPCFTSGRLRQAFP------IIARYADRFIAKLEQTKL---------------EDSTDIKKLFGPYSLDVIASSSFSVDADSINNPD----DPFIINIKKVLNLNFWL---LLIKNVLPFSSYLFEFLHIDIIPRSIVDYFFNLIKQLKAQHD----------QSIKGDFLHVMIQNEIPQSEI-----------------------------------KSD--QDQPPKGLTEQEILSQSVLFIFGGYDTTTITITYLLYNLAINPDVLQILHSEIDSNFPKDT------------------------------------------------------PFSYEDLVGFQYLDQVLNESQ-RLIPTAPALERFCKKTVQIH-GLTIPE------GTVVAVPVHLLHKDPRFWSSPEEFRPE------RFSKDNI---------EEVNPYAFMPFGLGP-----------RNCIGM-RYAILVMKMILVRVLQSYTVETCKDTMIP-----LEFDWK--LQP-------TKQIKLRLVPRQK----------------------------------------------------------------------- Takifugu_rubripes_TrCYP3A30 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNYLPLFALETWILLITFTCLFVMYGKRTFGIFEKL----------------------------GISGPKP-TMYFGSICKYNNV------------------YYLDDQEC-----AQKYGKIWGTYELRKPMLVVMDPDLLKTILVKEC-----FTHFTNRR--NFCLNGDLYDAVNIAE-DDDWRRIRNVLSPLFTTGRIKQIFS------LMKRQSSKLTSSLEPKAE--------------NEEIISIKDFFGAYNMNVATGVLFGMEME----PS----LPIKHASK---LFKFPIPL-FMIQGCFPILLPLLQLMGFSLFPRDSFAFVKKIVEKIRAERDGG----SHQVCTGRTRMLTTYTSTEFDFLQH-----------------------------------MIS---TQKNDGLTDHEIVSQLTVLLTGGYETSTLALTLSIYSLATNPGSMNRLQEEIDATFPDAA------------------------------------------------------PVTYEALMQMEYVDCVINECL-RLYPPAARLERTAKETVEIS-GITIPK------NMTVTVPIFALHRDPEHWPEPEEFKPD------RFSKQNK---------GRINPYTYLPFGIGP-----------RKCLGM-RLALVIVKLALVETLQKYSFSVCKETEIP-----FKMDPNTFVGP-------INPIKLRVVRR------------------------------------------------------------------------- Takifugu_rubripes_TrCYP3A40 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDLLLNFSIETWTLLTLIFTLIIVYGYAPYGFFKKV----------------------------GIPGPKP-WPFIGTFLNYRRG------------------IHHFDEEC-----YKKYGKVWGLYDGRQPLMCIMDTGMIKTVLVKEC-----YSNFTNRR--DLGVNGPLSDAVSVAE-DEQWKRIRGILSPSFTSGRLKEMYT------IMLQHSKNLLNFLNKKVE--------------ADEVIDVKDVFGPYSMDVVTSTAFSVDIDSINNPS----DPFVANIKEMTQFSFLNPL-VVLTVLFPFLVPIFKKMNVSTFPAHVIDFFFNFLRQIKSDRN-------KDKKKSRVDFMQLMVNAQMQEGN------------------------------------EEG---SS-QKGLTDNEILAQAMIFIFGGYETTSSSLGFLAYNLATNPKIQKKLQEEIDKTFPGKV------------------------------------------------------RPNYDDLMQLEYLDMVVNESM-RVFPILSRLERMTKTSVEIN-GFTIPK------GTVVAIPVYVLQHDKAYWPEPEAFKPE------RFSKENK---------DNVDPYAYLPFGAGP-----------RNCIGN-RFALVLMKLAIAEILQHYSFVPCKETDIP-----MVLNTEGLVAP-------KNPIKLKLKPRAVSS--------------------------------------------------------------------- Takifugu_rubripes_TrCYP4T10 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEITRALVVLGWSH--FYQLLA---LFCLAIVLYKLTVLLMLKRALIRNFE----------------------------SFPGPPG-HWLFGNILEFKQD------------GNDLDKLVKFGQKY-----PYC---FPLWFGPFVCFLNIHHPEYVKTILASTE----PKDDLAYSFIQN-----WIGNGLLVSQ-GQKWFRHRRLLTPGFHYDVLKPYVK------LMAHSTKTMLDKWESYAKT--------------NKPLEVFEYVSLMTLDTILNCAFSYDSNCQTES----------------------------------PHGFRYRKACMVAHSHTEEVIKKRREALKKEKE-------LERIQAKRNLDFLDILLFAKDENQ---------------------------------------------QGLLDEDIRAEVDTFMFEGHDTTASGISFLLYNLACHPKHQKLCRKEIMQVLHGKD------------------------------------------------------TMDWEDLNKIPYTTMCIKESL-RMHPPVPGISRKTTKPITFFDGRTLPA------ESRIGTSVFGIHRNASIWENPNVFDPL------RFLPENI---------SKRPPHAFVPFSAGP-----------RNCIGQ-NFAMNEMKVVIAMTLLKYELLEEPTLK-------PKIIPRLVLRSL-------NGIHIKIKNANQN---------------------------------------------------------------------- Takifugu_rubripes_TrCYP4V2 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MADLLGGFTLPLLGASVFVAALTCFTYRMLSDYLHKWFQMK----------------------------PIPELEGTYPLIGNALQFKPNA-----------GDFFNQIVEYTREN-----YHRP-LFKIWVG-PVPFVVLFHPETVEPVLTNAV---HMEKSYSYSFLHP-----WLGTGLLTST-GPKWRRRRKMLTPTFHFSILADFLE------VMNEQAEILVEKLDQQAGK---------------GPFNCFSYVTLCALDIICETAMGKKIYAQSNSE-SEYVKCVSKMSDIISRRQRTPWFWPNFAYYSIGDGREHDSTLKVLHSFTYKVITERAENVSSVESDSD-----SDHGRKKRQAFLDMLLKTTDEDG---------------------------------------------NKMSHRDIQEEVDTFMFRGHDTTAASMNWVLHLMGSHPEAQSKVHQELQEVFGESNR-----------------------------------------------------PITTEDLKKLKYLESVIKEAL-RLFPSVPFFARSLGEDCHIN-GFKVPK------GANAVIITYALHRDPRYFPEPEEFRPE------RFLPENS---------VGRPPYAYLPFSAGL-----------RNCIGQ-RFALIEEKVVLASILRKFNVEACQKREE------LRPVGELILRPE-------KGIWIKLEKRKPLIPPS------------------------------------------------------------------ Takifugu_rubripes_TrCYP11C1 -----------------------------------------------------------------------------------MWLPAGAGVRARSARG-------------------------------------------------------------------------------------FRTAAGAVVDG-----KVGACKGAEVPESKKGVDGQVRSFE-----------------------------EIPHTG-RNSWVNLLRFWR----------------EDRFRHLHKHMERT--FNSLGPIYREHVGTQSSVNIMLPSDISELFRSEG---LHPRRMTLQPWATHRETRQHGK-GVFLKNGEEWRADRLLLNKEVMMSEAVRRFIP-----LLDEVAQDFCHMMQTKVEREGRG-ERG----KRSLTINPSPDLFRFALEASCHVLYGERIGLFSSSP----SLESQKFIWAVERMLAT--TPPLLYLPHRLLLHLGAPLWTQHASAWDHIFTHAEERIQRGYQRL-------SHSQSRGP-EGGGRYKGVLG------------------------------------------QLMAKGQLSLELIKANITELMAGAVDTTAVPLQFALFELGRNPEVQQRVRQQVQESWAQAGG------------------------------------------------------DPQKALQEAPLLKGTIRETL-RLYPVGTTVQRYPV-KDIVLQNYHIPA------GTMVQACLYPLGRSAEVFEDPLRFDPG------RWGKSREEGQR-----GGGTGFRSLAFGFG-----------ARQCVGR-RIAENEMQLLLMHILLGFDLSV-PSSEDIKTMCT-----LILMPET--------PPKITFTKL------------------------------------------------------------------------- Takifugu_rubripes_TrCYP17A1 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDWVLFVYAFSAVNLALLALHLKFRTP--------------------------ASGPRGPPRLPALPLIGSLLSLRSP---------------HPPHVLFKELQ------GKYGQTYSLMMGSHRVIIVNHHAHAKEVLLKKG---KIFAGRPRTVTTDVLSRDGKD--IAFGDYSATWRFHRKIVHGALCMFGEGSAS-------IEKIICAEAASLCSILSEA-----------WTAGLALDLSPELTRAVTNVICSLCFSSSYRRGDAEF----EAMLHYSQG-IVDTVAK----DSLVDIFPCLQIFPNADLRLLKRCVSVRDKLLQKEYDKHKAAY-------SDHVQRDLLDALLRAKCSAENN------------------------------------NTTGINAESVGLTDDHLLMTVGDIFGAGVETTTTVMKWAITYLIHHPQIQSRIQEELDSRVGMDRS------------------------------------------------------PQLSDRGSLPYLEATIREVL-RIRPVAPLFIPHVALSDTSIGDFAVKK------GTRVVINLWSLHHDEKEWENPERFDPG------RFLNSEGT-G------LVIPSSSYLPFGAG-----------VRVCLGE-ALAKMELFLFLSWILQRFTLTVPSG-HSLPSLEG-KFG--VVLQPT--------KYKVNATPRPGWEG--KCKACWN----------------------------------------------------------- Takifugu_rubripes_TrCYP17A2 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDSPLLSTLSTFLSPSSLLSLRPSFSPTLFLIFFIMVTVGSFLIFRRPVRGS------------------EPGSEAGPPRVKVPCISWVPVLGSLPWLRGG---------------RPLHLIFTQLS------YRYGPLFALYLGPHLTVVVNNHQHAREVLLLRG---KDFAGRPRMVTTDLLTRGGKD--IAFSDYCPLWKSHRRLVQNSFTLFGEGTSR-------LQDMVLAAVDSLCEELLSM-----------EGRG--FDPAPAVTRAVTNVVCMLVFSATYRHGDSEL----QEVLRYNDG-IVQTIAG----GGLVDIYPWMKVFPNKTLSKLKACIAVRDRLLTHKLEEHKATL-------TDNQPRDLLDALLMGQVGR-GR------------------------------------RKGSGRVEEDIITEDHVLMTAAEAFGAGVETTSTTLLWILAYLLHHPQVQERVQKELDDHVGSERP------------------------------------------------------VRVSDRARLTYLDCVINEGM-RIRPVSPVLIPHTAMTDSSIGGHHISR------GTRVLVNMWSIHHDSAHWDKPDLFNPD------RFRDHQGQ---------RVTPSCFLPFGAG-----------PRVCVGE-SLARLELFLFLSSLLQRMSFRLPNG-ASPPDLQG-RMG--VVLQPV--------PYKVVVTPRVG----------------------------------------------------------------------- Takifugu_rubripes_TrCYP19A1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------MDLIC--DWAMAAVG--LDAEVLVSVSPNATE-AESPGSSAGTRALIILTCLLLLVWSHTE----------------------------KKS-VPGPSFCLGFGPLLTYVR-----------FIWTGIG-TASNYY-----NKKYGDIVRVWVNGEETLVISRASAVHHVLKSWQ------YTSRFGSKQGLSCIGMNERGIIFNNNVTEWRKIRGYFTKALTGPAVQNTVE------VCNSSTQAHLDRLEDLA------------------QVDVLSLLRCTVVDISNRLFLDIPIN----------EKELLLKIHKYFDTWQTVLIKPDIYFKFGWIHQKHKTAARELQEAIEGLVEQKRRDLEQADKLE-----------NINFTAELLFAQNHGELS-------------------------------------------------AENVMQCVLEMVIAAPDTLSVSLFFMLLLLKQNPDVELQLLQEID--AVVGER-----------------------------------------------------QLQNGDLQKLRVLETFINECL-RFHPVVDFTMRRSLSDDVIE-GYRVPK------GTNIILNTGHMHR-TEFFLRPTEFCLQ----------NFE---------KNAPRRYFQPFGSGP-----------RACVGK-HIAMVMMKSILVTLLSQYSVCPHEGLTLDC----LPQTNNLSQQPVEHQ-EEAQQLSMRFLPRQRGSWQTV----------------------------------------------------------------- Takifugu_rubripes_TrCYP19A2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKPKETLNITASGPFTPLPLPLMMMMMMMLLLMMMMLFLTWNRP----------------------------QRQHVPGPLFLAGLGPLLSYCR-----------FMWTGIG-TACNFY-----NNKYGSLVRVWINGEETLILSRSSAVYHVLRSAH------YTARFGSRAGPECIGMEGQGVIFNSDVELWRRARVYFSKALTGPGLQRTVG------VCVTSTAKHLDCLVDMTDA--------------SGHVDALNLLRAIVVDISNRLFLRVPLN----------EKDLLTKIHNYFETWQAVLIKPDIFFKIGWLFDKHRRAAQELQDTMAALLKVKRKLVHEAEKLDD----------VLDFATELILAQEAGEFS-------------------------------------------------ADNVRQCALEMVIAAPDTLSISLFFMLMLVKQHPDVELRIVEELSTVSRTGEE-----------------------------------------------------GEENIDYQRLKVMESFINESM-RFHPVVDFTMRKALEDDTIE-GIRIRK------GTNIILNIGLMHK-TEFFPKPREFSLT----------NFE---------QTVPSRFFQPFGCGP-----------RSCVGK-HIAMVMMKAILATLLSRYTVCPRHGCTLTS----IRQTNNLSQQPVE---DEHS-LAMRFIPRTIQSPS------------------------------------------------------------------- Takifugu_rubripes_TrCYP20A1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLDFAIFAVTFVIVLVGAVLYLYPSSRRASG-----------------------------IPGLNPTDEKDGNLQDIVGR---------------GSLHEFLVSLH------QEFGPVASFWFGSRPVVSLGSLQQLRQHINPNH------STDSFETMLKSLLGYHSG-----GGAASTDSIIRKKVYQGAIDTTLKNNFP------LVLKLVDELVGKWKSFP---------------EDQHTPLCAHQLVLAMKTITQLALGESFSEDARVIA------FRKNHDVIWSEIG--------KGYMDGSLEKSTSRKGHYEKALSEMESTLLSVVKERKSQ----------RNKSVFVDSLIQSTLTER-----------------------------------------------------QIMEDCMVFMLAGCAITANLCIWALHFL?TSEEVQDRLYKEFEEVLGSSPV-------------------------------------------------------SLEKIPQLRYCQQVLNETL-RTAKLTPIAARLQEVEGKVD-QHLIPK------ESLVIYALGVILQDSDTWNAPYRFDPD------RFEEESVK-----------KSFHLLGFSGS------------QTCPEL-RFAYTVATVLLSVLVRQLKLHRLKDTLMEVRSE-------LVSTPR-------DETWITFNLRN------------------------------------------------------------------------ Takifugu_rubripes_TrCYP26A1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVSALLATFLCTIVLPLLLFLVTVKLWEVYVIRERDSAC-------------------------PSPLPPGTMGLPFIGETLQLILQ------------------RRKFLRMK-----RQKYGYIYRTHLFGNPTVRVTGANNVRHILLGEH--------RLVAVQWPASVRTILGSDTLSNVHGAQHKTKKKAIMQAFSREALEFYIP-----AMQHEVQAAVQEWLAKDS------------------CVLVYPEMKRLMFRIAMQILLGFQLEQIKTDE----QKLVEAFEEMIKNLFS-------------LPIDMPFSGLYRGLKARNFIHAKIEENIKRKLRE---------SNSDSKCRDALQQLIDSSK--------------------------------------------KSGQVLSMQVLKESATELLFGGHETTASTATSLIMFLGLNPEVLDKLRHELSDK--ERQG-----------------------------------------------VDLRS--LNLETLEQLKYTSCVIKETL-RMNPPVP-GGFRVALKTFELGGYQIPK------GWNVIYSICDTHDVAEIFPNKEDFQPE------RFMMKNCGD---------SSRFQYIPFGGGS-----------RMCVGK-EFAKVLLKIFLVEVVTKCHWSLLNGP-PTMKTGP-------TVYPVD-------NLPTKFNTYVQN---------------------------------------------------------------------- Takifugu_rubripes_TrCYP26C1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLGLVSALATALTTLLLLLLLLALTRQLWSFRWSLTRDRRC-------------------------ELPLPKGSMGWPLVGETFQWLFQ------------------GSNFHISR-----RKRHGNVFKTHLLGKPLVRVTGAENIRKILLGEH--------SLVCTQWPQSTRIILGPNALVNSIGELHKRKRKILAKVFSRKALESYLP-----RLQEVIKCEIAKWCAEPG------------------SVDVYAATRSLTFRIAIGVLLGLHLEEERID------YLAQIFGQLMSNLFS-------------LPIDAPFSGLRKGIKARKILHANMEKIIEKKMER---------QQEEEEYRDAFDYMLSTSK--------------------------------------------EQGQQISIQELKETAVELIFAAHSTTASAATSLVLQLLHHPEVVERVRVELEAQKLCYN------SLNLPSQACGQKKD--QSTNLLRGT--------------FPQSQCHASNLSLDKLNQLHYIDCVIKEVL-RFLPPVS-GGYRTALQTFELDGYQIPK------GWTVMYSIRDTHETAEIFQNPELFDPD------RFVTAQVESR--------SSRFSYVPFGGGV-----------RSCVGK-ELAQIILKTLTIELIRTCKWTLATEKFPKMQTVP-------IVHPVN-------GLHVNFMYKNLHEIDH------------------------------------------------------------------ Takifugu_rubripes_TrCYP27C1 --------------------------------------------------------------MSVMNKLTTTCWTNFYGDRRNKQMLFVLRCLHKSAT----------------------------------------------------------------------------------------SGTFGVAR--EEPLPERLITSTDA-----TKKRLPKTLA-----------------------------EMPGP---GTISNLFEFFW----------------RDGFSRIHEIQIEH--SKMYGKIFKSRFGPQLVVSVADRDLVAEVLRAEG---VAPQRANMESWHEYRDMRRRST-GLISAEGEDWLRMRSVLRQLIMRPRDVAVFSD-----DVSEVVDDLIKRIVCLRSQSSDGT----------TICNINDLFFKYAMEGIAAILYECRLGCLSQKI----PQETEDYIDALHLMFSSFKTTMYAGAIPKWLRPVFPKPWEEFCDSWDGLFRFSCVHVDKRLKQI-------ESQLQRGE----KVTGGLLT------------------------------------------YMLVAKEMSVEEIYANVTEMLLAGVDTTSFTLSWASYLLARHPDVQQQIHAEVMRVLGSEKV------------------------------------------------------ATAEDVQHLPFIRGLVKETL-RLFPVLPGNGRITQ-DDMVLGGYFIPK------GTQLALCHYSTSLDDENFPSSLEFRPD------RWIRK-HSSDR-----LD--NFGSIPFGYG-----------IRSCIGK-RIAELEMHLALIRIIQKFHVCVSPLTTDVKAKTH-----GLLCPGA--------PINLQFIDREI----------------------------------------------------------------------- Danio_rerio_DrCYP1A -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALTILPILGPISVS------ESLVAIITICLVYLLMRLNRTKIP--------------------------DGLQKLPGPKPLPIIGNVLEIGN-----------------NPHLSLTAMS------KCYGPVFQIQIGMRPVVVLSGNDVIRQALLKQG---EEFSGRPELYSTKFISDGKSL--AFSTDQVGVWRARRKLALNALRTFSTVQGKSPKYSCALEEHISNEGLYLVQRLHSVMKA-----------DGSFDPFRHIVVSVANVICGICFGRRHSHDDDEL----VRLVNMSDEFGKIVGSG--NPADFIPFLRILPSTT---MKKFLDINERFSKFMKRLVMEHYDTF-------DKDNIRDITDSLINHCEDRK-----------------------------------------LDENSNLQVSDEKIVGIVNDLFGAGFDTISTALSWAVVYLVHYPEVQERLQRELDEKIGKDRT------------------------------------------------------PLLSDRANLPLLESFILEIF-RHSSFLPFTIPHCTSKDTSLNGYFIPK------DTCVFVNQWQVNHDPELWKDPSSFIPD------RFLTADGT-EL-----NKLEGEKVLVFGLG-----------KRRCIGE-SIGRAEVFLFLAILLQRLKFTGMPGEMLDMTPE---YG--LTMKHK--------RCLLRVTPQPGF---------------------------------------------------------------------- Danio_rerio_DrCYP1B1 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMDVLLALRDL------------LQLSTRSVLLSLMVCLMLMF--------------------------RRRQLVPGPFSWPVIGNAAQLGN-----------------TPHFYFSRMA------QKYGDVFQIKLGSRNVVVLNGD-AIKEALVKKA---TDFAGRPDFASFRFVSNGKSM--AFGN-YTPWWKLLRKVAQSTVRNFSTANIQTKQT---FEKHIVSEIGELIRLFLNKSRE-----------QQFFQPHRYLVVSVANTMSAVCFGNRYAYDDAEF----QQVVGRNDQFTKTVGAG--SMVDVMPWMQYFPNPIRTLFDQFKELNKEFCAFIELKVSEHRKTI-------SPSHVRDMTDAFIVALD-KG-----------------------------------------LSGGSGVSLDKEFVPPTISDIFGASQDTLSTALQWIILLLVRYPEIQNRLQEDVGRVVDRSRL------------------------------------------------------PTIADQPHLPYLMAFIYEVM-RFTSFTPLTIPHSTTKDTSINGYPIPK------DTVIFVNQWSLNHAPAKWDQPEVFNPQ------RFLDEDG--SL-----NKDLTTNVLIFSLG-----------KRRCIGE-DVSKIQLFLFTSVLVHQCSFKAES--TPNMDYE---YG--LTLKPK--------PFKVSVTARDSSDLLDSLVGTSQTPTEKRLKCN------------------------------------------------- Danio_rerio_DrCYP1C1 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGRIMEAEFGLKSSSIMREWSGQVQPALIASFIILFFLEACLWVRNL-------------------------TFKKRLPGPFAWPLVGNAMQLGQ-----------------MPHITFSKLA------KKYGNVYQIRLGCSDIVVLNGDAAIRKALVQHS---TEFAGRPNFVSFQMISGGRSS--TFTN-YSKQWKTHRKVAQSTLRAFSMANSQTRKT---FEQHVVGEAMDLVQKFLRLSAD-----------GRHFNPAHEATVAAANVVCALCFGKRYGHDDPEF----RTLLGRVNKFGETVGAG--SLVDVMPWLQSFPNPVRSVYQNFKTINKEFFNYVKDKVLQHRDTY-------DPDVTRDMSDAIIGVI--EH-----------------------------------------GKESTLT---KDFVESTVTDLIGAGQDTVSTAMQWMLLLLVKYPSIQSKLQEQIDKVVGRDRL------------------------------------------------------PSIEDRCNLAYLDAFIYETM-RFTSFVPVTIPHSTTSDVTIEGLHIPK------DTVVFINQWSVNHDPQKWSDPHIFNPS------RFLDENG--AL-----NKDLTNSVMIFSTG-----------KRRCIGE-QIAKVEVFLFSAILLHQCKFERDPSQDLSMDCS---YG--LALKPL--------HYTISAKLRGKLFGLVSPA--------------------------------------------------------------- Danio_rerio_DrCYP1C2 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHRSSSSAVWR------------LVFGLEISLLK------------------------------KKRLPGPFAWPLIGNAMQLGQ-----------------MPHITFSKLA------KKYGNVYQIRLGSSDIVVLNGESAIRSALLQHS---TEFAGRPNFVSFQYVSGGTSM--TFAS-YSKQWKMHRKIAQSTIRAFSSANSRTKKS---FEKHIVAEAVDLVETFLKS---------------QHFNPSHELTVAAANIICALCFGKRYGHDDLEF----RTLLGNVNRFSETVGAG--SLVDVMPWLQTFPNPIRSIFQSFKDLNNDFFSFVKGKVVEHRLSY-------DPEVIRDMSDAFIGVMD-HA-----------------------------------------DEETGLT---EAHTEGTVSDLIGAGLDTVSTALNWMLLLLVKYPSIQSKLQEQIDKVVGRDRL------------------------------------------------------PSIEDRCNLAYLDAFIYETM-RFTSFVPVTIPHSTTSDVTIEGLHIPK------DTVVFINQWSVNHDPQKWSDPHIFNPS------RFLDENG--AL-----DKDLTSSVMIFSIG-----------RRRCIGD-QIAKVEVFLISAILIHQLTFESDPSQDLTLNCS---YG--LTLKPF--------DYKISAKPRGSIVN-------------------------------------------------------------------- Danio_rerio_DrCYP1D1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKTRFANTDIKVYAMNLENISHTATS------EVTLILCAFALLLLALHGRRRAP----------------------------GVPVPPGPRPWPIVGNFLQMEE-----------------QVHLSLTNLR------VQYGDVFQVKMGSLVVVVLSGYTTIKEALVRQG---DAFAGRPDLYTFSAVANGTSM--TFSEKYGEAWVLHKKICKNALRTFSQTEPKDSNASCLLEERICVEAIDMVETLKAQGEE---------FGDSGIDPVQLLVTSVANVVCTLCFGKRYSHNDKEF----LTIVHINNEVLRLFAAG--NLADFFPIFRYLPSPS---LRKMVEFINRMNNFMERNIMEHLVNF-------DTNCIRDITDALIAMCEDRQ-----------------------------------------EDKES-AVLSNSQIVHSVIDIFGAGFDTIITGLQWSLLYLIKFPNIQDKIVQEIDNQVGMDRL------------------------------------------------------PQFKDRPNMPYTEAFINEVF-RHASYMPFTIPHCTTENITLNGYFIPK------DTCVFINQYQVNHDIEIWDDPESFRPE------RFLTLSG--HL-----NKSLTEKVMIFGMG-----------IRRCLGD-NIARLEMFVFLTTLLHRLHIENVPGQELDLSST---FG--LTMKPR--------PYRIKIIPRN------------------------------------------------------------------------ Danio_rerio_DrCYP2AA1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSRTQSVIMLVGLVKLDLASVGLTLFLGLIFLVLFEIFRIHSYKGR----------------------------FPPGPTPLPFVGNLPHFLK----------------S--PMEFIRFM------PQYGEMTTIFFGRKPVIMLNTIQLAKEAYVQD-----VFSGRPAIPLFD-WITNGLG--IVMVTFNNSWRQQRRFALHTLRNFGLGKKT-------VEDRVLEESRYLIAEML-------------KEEGKSMNPQHALQNAISNIICSIVFGDRFEYDNKRF----EYLLKTLNENIMLAGS---AAGQIFNLVP-FIKHFPGPHQKIKQNADELLGFIRDEAKEHRQTL-------DPDSPRDFIDAYLLEIEKQK-----------------------------------------SSKDS--TFHEENLVVSASDLFLAGTDTTETTIRWGLINLIQNPDVQERCHEEIVRVLGYDRL------------------------------------------------------PSMDDRDKLPYTLATVYEIQ-RCANIAPN-VMHQTILPTKLHGYNIPQ------GTIILTNLAAIFSNKEHWKHPDAFNPE------NFLDENG---------HFSKPESFIPFSLG-----------PRVCLGE-TLARTELFLFITALLQRIRFSWPPDAKPIDMDG--IMG--LVRSPQ--------TFNVVCHSRDNVK--------------------------------------------------------------------- Danio_rerio_DrCYP2AA2 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLAALLKLDLATVGLTLFLGLIFLVLFEIFRINSYKGR----------------------------FPPGPTPLPFVGNLPHLLK----------------N--PMGFKRSL------SEYGGLATVFIGRQPAISINTIQLAKEALVQD-----VFSGRPPLPIFD-WISHGLG--IIMVTFNHSWRQQRRFALHTLRNFGLGKKT-------VEDRVLEESQYLIAEML-------------KDEGKSMNPQHALQNAVSNIICSIVFGDRFEYDNKRF----EYLLKILNENIMLTGS---AAGQIFNLVP-FIKHFPGPHQKVKQNADDLFNFIRDEAKEHKQTL-------DPDSPRDFIDAYLLEIEKQK-----------------------------------------SSKES--TFHEEHLVVSTSDLFLAGTDTTETTIRWGLIYLIQNPDVQERCHEEIVQVLGYDRL------------------------------------------------------PSMDDRDKLPYTLATVHEIQ-RCGNIAPK-LLHETIRRTKLHGYDIPQ------GTTIIANFTAMFSDKELWKHPDAFNPE------NFLDENG---------QFSKPEYFFPFSLG-----------PRACLGE-ALARTELFLFITSLLQRIRFSWPPNAKPIDMDG--IVG--IVRSPE--------PFNIICHSRDTKD--------------------------------------------------------------------- Danio_rerio_DrCYP2AA3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLLLCLSRTQSVIMFTALLKLDLASVGLTLFLGLIILVLFEIFRIHSYKRR----------------------------TPPGPTPLPFVGTIPHFLK----------------N--PLGFIRSM------SQYGDMSTMYLGRKPAIFLNTIQLAKETLVQD-----TFSGKPYLPVIE-WISKGFG--IAMVTFNHSWRQQRRFALHTLKNFGLGKKS-------VEDRVLEESRYLIAEML-------------KDEGKPVDPHHPIQNAVSNIICSIVFGDRFEYNNKRF----EYLLKMLNETIMLAGS---ASGRIFNLVP-FIKHFPGPHQKIKKNTDDLLIFLGDEVEEHRKTL-------DPGSPRDFIDAYLLEIEKQK-----------------------------------------FNKDS--TFHEGNLLASAGDLFMAGTDTTETTIRWGLLFLIQNPDVQERCHEEIVQVLGYDRL------------------------------------------------------PSMDDRDRLPYTLATVHEIQ-RYGNIIPI-LIHETILPTKLQGYSIPQ------GTTIVTNIQAIFSSKDHWKHPDSFNPE------NFLEDR----------HFIKPESFIMFSLG-----------PRSCLGE-ILARTELFLFITSLLQRIHFSWPPDAKPIDMDG--IFG--LVHSPQ--------AFNVICRSRDTK---------------------------------------------------------------------- Danio_rerio_DrCYP2AA4 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFGALVKLDLSSVGLTLLLGLILLVLFEIFRIHSYKSR----------------------------FPPGPTPLPFVGNLPHLLR----------------D--PMGFNRLM------AQYGEMSTMYLGKKPAIVLNTIQVAKEALVQE-----AFAGRPCLPVID-WTSNGCG--IIMATFNNSWKQQRRFALHTLRNFGLGKKS-------IESRVLEESQYLFAELL-------------KDEGEPVNPHHALQNAVSNIFCSIMFGERFDYDNKRL----GYLLKILNENMMLTGS---AIGQIFNLAP-FIKHFPGPHQKIKKNSNELYSFIEDEVEEHRKTL-------DPVSPRDFIDAYLLEIEKQK-----------------------------------------SNKDS--TFQEENLIGSAIDLFFAGTDSTATSIRWGLLFLIQNPDVQERCHEEIVQVLGYDRL------------------------------------------------------PCMDDCDRLPYTHATVHEIQ-RFAKTVPFGVFHETIWPTKLHGFDIPQ------GTMIMTNLAAIFSSKEHWKHPDTFNPE------NFLDENG---------HFSKPESYIPFSLG-----------LRACIGE-SLVRTELFLFATVLLQRIHFSWPPDAKPLDMDG--IVG--IVRYPQ--------TFSIICCSRDSKK--------------------------------------------------------------------- Danio_rerio_DrCYP2AA6 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSVIMLAALLKLDLSSVGLSLFLGLIFLVLFEIFRIHSCKGR----------------------------FPPGPTPLPFVGSIPHFLN----------------N--PMGFIKSL------SQYGEMTTVYPGRKPAIILNTLQLMKEALVQNG---SSFSGRPPVPVFN-WVTDGYG--IVMATFGHSWRQQRRFALHTLRNFGLGKKS-------VEERVTEESGYLISEFL-------------KAEGKPFNPQHAIHNAAANIICSIVFGDRFDYDNKSF----TYLLEIIKENIIQAGS---LVGQVFNLVP-IIKHVPGPHQKIYQNGQAFKSFIRESVKEHRQTL-------DPDSPRDFIDAYLLEMEKQK-----------------------------------------STQDS--TFHEDNMVMAVGDLFLAGSDTTATTIRWGLIYLTQNPDVQERCHEEIVRVLGFDRL------------------------------------------------------PSMDDRDRLPYTHATVHEFQ-RCANLVPTGVPHQTTQATKLRGYDIPQ------GTQILINLTEILTNKEHWKHPDTFNPE------NFLDDKG---------HFFKPEAFLPFSLG-----------PRACLGE-TLAKAELFLFVTSLLQRIRFSWPTGEKLPDMNG--IFG--IVRSPK--------PFNIICHSRGSKH--------------------------------------------------------------------- Danio_rerio_DrCYP2AA7 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVNMFAALLKLDLASVGLTLFLGLIFLVLFEIFRINSYKGR----------------------------FPPGPTPLPFVGNLPHSLK----------------N--PMEFIRSM------PQYGEMTTMYLGRRPAIVLNTIQLAKEAFVQD-----AFSGRPFLPVMD-WVANGLG--IIMVTFNHSWRQQRRFALHTLRNFGLGKKS-------VEDRVLEESRYLIAEIL-------------KGEGKPMSPHHPIQNAVSNIICSIVFGDRFDYDNKRF----EYLLELLNENFVLTGS---AAGQIFNLAP-FIKHFPGPHQKIKQNANELLAFIQGEVKEHKKTL-------DPDSPRDFIDAYLLEIEKQK-----------------------------------------SNKDS--TFHEGNLAISTADLFLAGTDTTSTTIRWGLLFLTQNPDVQERCHEEIVQVLGYDRL------------------------------------------------------PSMDDRDKLPYTLATVHEIQ-RCANLVPFGVIHETIQPTKLRGYDIPQ------GTVVMTNLAAILSDKEHWKHPDTFNPE------NFLDENR---------QFSKPESFIPFSLG-----------LRFCLGE-TLAKMELFLFITSLLQRIHFSSPPDAKPIDMDG--VVG--IVRYPQ--------PFSIICCSRDTTK--------------------------------------------------------------------- Danio_rerio_DrCYP2AA8 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRSSGFIHSKVDFHLVHH----------------------------------------------LPFVGNLPVFLK----------------N--PMEFIRSL------SQYGEMTTIYLGRKPTIMLNTVQLAKEVLIQD-----AFAGKPSLPVLD-WVSNGLG--IVMVTFNHSWRQQRRFALHTLRNFGLGRKS-------VESRVLEESQYLIAELL-------------KKKGKSVNPQHALQNAFSNVICSIVFGDRFDYDDKRF----EHFLEILGKSMILTGS---TAGQIFNFAP-IIKHFPGPHQKIKKNADELSGFFQHEVKEHKKTL-------DPGSPRDYIDAYLLEMEKQK-----------------------------------------SNKDS--TFHDENLIGSTTDLFVAGSDSTATTFRWGLLFLIQNPDVQERCHKEIVQVLGYDRL------------------------------------------------------PSMEDRDRLPYTLATVYEIQ-RCANLAPFGLIHETIQPTKLQGYDLPR------GTTIIVNLTAIFSNKENWKHPDTFNPE------NFLDESG---------QFSKHESFIPFSLG-----------VRVCLGE-TLARTELFLFITALLQRIRFSLPPDAKPMDMDG--ILS--VLRYPQ--------NFSFICCSRDTKE--------------------------------------------------------------------- Danio_rerio_DrCYP2AA9 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVIMFTALLKVDLASVGLTLFLGLIFLVVFEIFRIYSYKCR----------------------------FPPGPTPLPFVGNLPHLLK----------------K--PMEFIRSL------SQYGEMTTMYLGRKPAIVLNTYQVAKEALVQE-----AFAGRPHLPIIE-WITKGLG--IVMVTFNNSWKQQRRFAQHTLRNFGLGKKS-------LESRVLEESQYLIAEML-------------KDEGRPMNPQHAVQNALSNIICSIVFGDRFDYNNKRF----EYLLKILNESIILTGS---AAGQIFNFAP-IIKHFPGPHQMINENANEVYSFVRHEVEEHRKTL-------DPGSPRDFIDGYLLEIEKQK-----------------------------------------SNKDS--TFHEDNLITTTVDLFLAGSDSTSSSIRWGLLFLIQNPDVQERCHEEIVQVLGYDRL------------------------------------------------------PCMDDRDRLPYTLATVHEIQ-RCGNIAPFGLFHETAQPTKLRGYNIPQ------GTIIMTNYTAIFSNKEHWKHPDTFNPE------NFLDENG---------HFSKPKCFIAFGVG-----------PRICLGD-TLAKTALFLFITSLLQRIRFSLPPDAKPMDMDG--ILS--IIRYPE--------TFCIICCSRDTKE--------------------------------------------------------------------- Danio_rerio_DrCYP2AA11 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLVGLLKLDLSSVGLSLFLGLFCLALFEICRIRIYKGR----------------------------YPPGPTPLPFVGTIPHFLK----------------N--PMGFIRSL------SQYGEMTTVYLGRKPAIILNALQLMKEAFVQNG---SSFSGRPPVPVLT-WVNQGYG--IIMAMDGHSWRQQRRFALHTLRNFGLGKKS-------VEERVTEESGYLISELL-------------RVEGKPFNPQHAIHNAAANIICSIVFGDRFDYDNKSF----TYLLEIIKENLDLAGS---FAGQMVNLVP-IIKNLPGPHQKIYQNGEEFKSFIRESVKAHRETL-------DPDSPRDFIDAYLLEMEKQK-----------------------------------------STQDS--TFHEDNMVMSVGDLFFAGTDTTATTIRWGLLYLTQNPDVQERCHDEIVQVLGFDCF------------------------------------------------------PSMDDRDQLPYTLATVHEIQ-RCANVAPSGVPHQTTKPIKLRGYDIPQ------GTQILINLMGILANKEHWKHPDTFNPE------NFLDDKG---------HFFKPEAFLPFSLG-----------PRACLGE-TLAKTELFLFVTSLLQRIRFSWPTGEKWPDMNR--ILS--VIRSPE--------PFNIICYSRDSKH--------------------------------------------------------------------- Danio_rerio_DrCYP2AA12 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSCNQSAIMFASLLKLDLASVGLTLFLGLIFLVVFEIFRIRSYSGR----------------------------FPPGPTPLPFVGTIPHFLK----------------D--SMGFIRSL------SQYGEMTTVYLGRKPAMVLNTLQVIKEAIVQNG---TSSSGRPSIPILT-WITEGYG--IVLATFGHSWRQQRRFALHTLRNFGLGKKS-------VEERVTEESGYLVPEML-------------KLEGKPFDPQHAIQNAVSNIICSIVFGDRFEYDNKRF----EYLLEIIKENINQAGS---LIGQVFNLIP-IIKHFPGPHQKIYQNAEELKSFIRESTKSHRETL-------DPDSPRDFIDAYLLEMEKQK-----------------------------------------SSQDS--SFHEDNMVMSVADLFLAGSDTTATTIRWGLIYLTQNPDVQERCHEEIVRVLGYDRL------------------------------------------------------PCMDDRDRLPYTLATVHELQ-RCGNIVPSSVPHETTQPMKLRGYDIPQ------GTQMLINLSDILANKEHWKHPDTFNPE------NFLDDKG---------HFYRPEAFLPFSLG-----------PRVCLGE-TLAKTELFLFITSLLQRIRFSWPTGEKWPNMDG--IVS--VVRSPE--------PFKIICHSRGSKE--------------------------------------------------------------------- Danio_rerio_DrCYP2AD2 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MILHLIYDSFDFKSWIIFFVVFLIIAEMIK-NRTPSN-----------------------------YPPGPWPLPFLGTVFTKM-------------------DFKNINKLA------KVYGKVFSLRVGSEKMIIVSGYKMVKEALVTQN---DSFVLRPPVPLFHKVYKGI----GLTMSNGYIWRSHRRFAASHLRTFGEGKKN-------LELGIQQECVYLCDAFK-------------AEKE-PFNPIFILHGAVSNTVACLTFGQRFDYNDEWY----QEILRLDNQCVQLAGS---PRVQLYNAFPKLLDYLPGPHQKVFSNYKKITQSLKDEIIKHREDW-------DPANPRDFIDNYLTEMEKKK-----------------------------------------SDPQA--GFNIESLIISCLDIVEAGTETGATTLRWGLLFMIKFPEIQKKVQAEIDRVIGQSRQ------------------------------------------------------PCLDDRVNMPYTEAVLHEIQ-RFGDVVPLGFPKQAAVDTKIGNYFIPK------GTSITTNLSSVLHDPNEWETPDTFNPG------HFLDKNG---------QFRKRDAFLPFSAG-----------KRACVGE-LLARNVLFLFFTSLLQQFTLSKCPGEEPSLEGE---IW--FTYAPA--------PFRISVSVR------------------------------------------------------------------------- Danio_rerio_DrCYP2AD3 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------MQGSRQYFCIQWQRRSYIFINTMILQFIYENFDFKSWILLGFGLLLLVDLIK-YWNPSS-----------------------------FPPGPRPLPFLGNVFTEIQ------------------DFRNINKLA------QVYGTIFSLRLGSEKLIIVSGYKMAKEALVTQN---DSFIDRPNVPLFHKVFKGL----GTILSNGYLWRMHRKFAVSHLRNFGVGNES-------LEVKIQQECIFLCDAFK-------------AEKG-PVDPMVTLNSAISNIISSLIFGQRFDYHDEYY----QRILRLDTECIQLAGS---PRAQLYNACPWLFEYLPGPHQTIFSNYKKIKDFLRGEIIKHREDW-------DPANPRDFIDNYLTEMERKK-----------------------------------------SDPEA--GFNIEGLVVTCLDLIEAGTETATTTLRWGLLFMIKFPEIQEKVQAEIDRVIGQSRQ------------------------------------------------------PCLNDRVNMPYTEAVIHEIQ-RFGDVVPLGFPKRAVKDTQLGKYFIPK------GTAITVNLSSVLHDPNEWETPDTFNPG------HFLDEIG---------QFRKRDAFMPFSAG-----------KRACLGE-NLARQELFLYFTSLLQQFKISKCPGEEPSLEGE---IW--FTYAPA--------PFHICVSSR------------------------------------------------------------------------- Danio_rerio_DrCYP2AD6 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MILYSLYDCLDFKGWLFLTCFLLLLIDLIR-NKNPAN-----------------------------FPPGPWPLPILGNVFTDV-------------------NYKTVDQLI------EKYGNIFSVRIGSDKIVYVSGFKMVKDVLITQG---ENFTDRPVSPLFDTLYKGR----GLSFNNGYSWRKHQQFSMSHLKNFGEGRKT-------LEENNQRECYFLCGAFK-------------EEQGRPFDPLVKINNAVANVIGFLVFGHRYEYSDVNF----QKRLQMSAESVFLTGS---VWNQLYDAFPGIMKWVPGPHQTIISNYQKLANFLEEKIEQHKPDW-------DISNPRDYIDAYLTEAEKKK-----------------------------------------NDTEA--GFTVGSLVWSMVDLFEGGTETTTNTLRWALLFLIKYPDIQKKVQAEIDEVIG-SRL------------------------------------------------------PSMSDKANMHYLNAFIHEVL-RRANLVPLNMARVAKKDTTLGGYFITK------GTVMITNLTSVLYDKQEWETPDAFNPK------HFLDSEG---------HFCRRNAFFAFSAG-----------KRQCPGE-YLAHLELFIFLTILLQTFSFSPPDGEEPSLDSQ---VG--FTQAPL--------PYKICAHPR------------------------------------------------------------------------- Danio_rerio_DrCYP2AE1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSVFSQLIGQWLDVQGFLIFLCVLLLVKHFRD--VYSKN-----------------------------MPPGPFPLPFVGNLTNIGF----------------SDPLGSFQRIA------EKYGDVCTLYLGTKPCILMTGYDTLKEAFVEQA---DIFTDRPYFPIVDKLGNG-KG---LIMSSGHMWRQQRRFALATLKYFGVGKKT-------LENAILQECRFLCDSLQ-------------AERGLPFDPQHLVTNAVSNIICGLVFGHRFEYDDHQF----HLMQTYINNILQLPIS---NWGRLYNEFPTLMSLLPGKHQTAFASMSKLQPFLKEEITKHQQDR-------EPSSPRDYIDCYLEEIEKCK-----------------------------------------DS-DA--EFTEENLMFCVVDLFGAGTETTSNTLRWALAFMVKYPDVQEKVQSEIDQVIGQTRQ------------------------------------------------------PLMDDRTNLPYTYAVIHEIQ-RFANIVTFTPPRVANKDTTVGGQLIPK------GVIVLPMLKPILLDKKEYSTPYDFNPD------HFLDQNG---------KFLKKENFIPFSIG-----------KRMCPGE-QLARMELFLFFISLMQHFTFLPVEGQKLSLKGT---TS--VSSAPQ--------PFQIRAVPR------------------------------------------------------------------------- Danio_rerio_DrCYP2K6 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTMALIEAFLLQGS-PTGAILGALLLFLVIYLFSSSSS-SQDKEK-----------------------------YPPGPKPLPLLGNLHILDL----------------KKTYLSLLELS------KRYGPIYTVYLGPKKVVILSGYKIVKEALVNLS---EEFGDRDISPIFH-DFNRGYG---IAFSNGENWREMRRFALSTLRDFGMGRKR-------SEELIIEEIKYVKEEFE-------------KFGGNPFETKLPLALAISNIIASIVFSVRFEYSNTKL----HRMVGRAYENMKLTGS---PSVQIYNMFPWLRPIVA-NRNQIVKNLKDTFKQNEELINGVMKTL-------DPFNPRGIVDSFLIRQQKDE-----------------------------------------ESGKTDSLYNSNNLYCTVNNLFGAGTDTTVTTLRWGLLLMAKYPEIQAKVQDEIERVIG-GRQ------------------------------------------------------PVVEDRKNLPYTDAVIHEIQ-RFADISPIGAPRQTTCDVHLNGYFIKK------GTPVFPLLVSVLRDEDEWEMPDSFNPK------HFLNKQG---------QFVKKDAFMPFGAG-----------RRVCIGE-SLARMELFLFFTSLLQYFRFTPPPGVSEDDLDLTPVVG--FTLNPK--------PHQLCAVKRS------------------------------------------------------------------------ Danio_rerio_DrCYP2K8 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVMETLLMPVSITG-VLLSAVLLFLVVYLISISS---SSPE------------------------------DPPGPKPLPLLGNLHTLDL----------------KNLHVSLWELS------KKYGPVFKVHLGRKKVVVLAGYKTVKQALVNQA---EEFGERDITPIFQ-DCNQGQG---IVFANGERWRTMRRFALSTLRDFGMGKKL-------SEEKIVDETRYLREVFM-------------KFEGQPFDTTQPVNYAVSNIISAIVYGKRFEYEDPAF----QDMVNKANMNIRMIGS---AVIQIYNMCPFLGPWIK-TWRQLMKNMESTRRQIQTLADVLQETL-------NPLDCRGLIDSFLIRKQNIQ-----------------------------------------ETGEKDSSFNDQNLLITVSNLFAAGTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDQVLG-GRE------------------------------------------------------PVAEDRKNLPYTDAVIHETQ-RLANILPLNLPHKTSCDVTFNGYFIKK------GTCVLPLLTSVLRDETEWETPDTFNPQ------HFLDEKG---------QLIKRDAFMPFSAG-----------RRACLGE-SLARMELFLFFTSLLQYFRFSPPPGASEDELDLTPVVG--LTLNPS--------PHKLCAVIRAERQLN------------------------------------------------------------------- Danio_rerio_DrCYP2K16 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFLDALLH-VSSTG-TLICFLLLLLVAYLLFLRS---QSDEN-----------------------------EPPGPKPLPLLGNLLMLDV----------------NKPHLSLCEMA------KQFGPVFKVYFGPKKVVVLAGYKAVKQALVNYA---EAFGDREIMPLFH-DFTKGHG---IIFANGESWREMRRFALTNLRDFGMGKKK-------IEEKIIEETCHLREEFE-------------KFEGKPFETAQLMNYAASSVISSIVYGRRFEYTDPQL----RTMVDRANESVRLSGS---ASVQLYNMFPFLGPLLK-NWRQLMKNLHLDIEEISELVNGLHQTL-------NHQDLRGFVDSFLVRKQYAE-----------------------------------------DSGEKDSHFHEQNLIYTVGNLFVAGTDTTSTTLRWSLLLMAKYPHIQDRVQEEIDQVIG-GRQ------------------------------------------------------PVSEDRKNLPYTDAVIHETQ-RLANIVPMSIPHMTSSDITFNGYFIKK------GTCIFPLLTSVLWDEDEWETPHIFNPN------HFLDEQG---------RFVKRDAFMPFSAG-----------RRICLGE-SLARMELFLFFTSLLQYFRFTPPPGVSEDELELTPAVG--FTLNPI--------AHKLCAVKRL------------------------------------------------------------------------ Danio_rerio_DrCYP2K17 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVVESLLH-FSSVG-TLLGTLLLLLVFYRLSRDSE-FQKKRK-----------------------------DPPGPKPIPLLGNLLTLDL----------------SRPFDSLCELS------KTYGNVYQVFLGPKKVVVLIGHKTVKEALVNFA---DEFGERDITPIFR-ILANDHG---ILFSNGESWKEMRRFAISNLRDFGMGKRG-------SEEKIIEEIHHLKGEFD-------------KFEGKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPRF----TEMVDRANENIRVSGS---ASMMLYNIFPWLGPFLN-SKRTVVRNMLKNRAEFMKLITGLQETL-------NIHDRRGFVDSFLIRKQSDE-----------------------------------------QLGKKDTYFHAENLLMTVGNLFAAGTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDRVIG-GRQ------------------------------------------------------PVVEDRKKLPYTDAVIHEIQ-RLANIVPMNLPHVTSCDVTFNGYFIKK------GTTVIPLLTSVLKDESEWEKPNSFYPE------HFLDEKG---------QFIKRDAFMPFSAG-----------RRVCLGE-SLARMELFLFFASLLQSYRFTTPPGVSEDELDLKGTVG--VTLNPS--------PHKLCAIKRF------------------------------------------------------------------------ Danio_rerio_DrCYP2K18 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVVESLLQ-FASTG-TLLGALLLFLVLYLVSSGSG-SQKEGK-----------------------------EPPGPKPLPLLGNLLTLDL----------------TRAFDTFFELS------KTYGNIFQVYLGPKKTVVLVGYKTVKEALVNHA---EAFGDREIGPSFR-IMNDEHG---IVFSNGENWKEMRRFALSNLRDFGMGKRG-------SEEKIIEEIHHLKGEFD-------------KFEGKPIDTTEPVNYAVSNIISSIVYGSRFEYTDPQF----TEMVDRANENVRVGGS---ISMGLYNMFPWLGPFLK-NKRIVVRNIIQSRVQMTKLITALLETL-------NPNDPRGFVDSFLIHKLSDE-----------------------------------------KSGKKNSYFHNENLMMNVANLFVAGTDTTGTTLRWGLMLTAKYPQIQDRVQEEIDRVIG-GRQ------------------------------------------------------PAVEDRKKLPYTDAVIHEIQ-RFANIVPLNLPHTTSCDITFNGYFIKK------GTTVIPLLTSVLKDESEWEKPNSFYPE------HFLDEKG---------QFVKRDAFMPFSAV-----------ILTLMSD-ARAIE----------------------------------------------------------------------------------------------------------------------------------- Danio_rerio_DrCYP2K19 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVVESLLQ-FASTG-TLLAALLLFLVLYLVSSGS---QKEGK-----------------------------EPPGPKPLPLLGNLLTLDL----------------TRAFDTFFELS------KTYGNVFQVFLGPRKTVVLVGYKTVKEALVNYA---EQFGDREIGPGFR-IMNDEHG---ILFSNGENWKEMRRFALSNLRDFGMGKRG-------SEEKIIEEIHHLKGEFD-------------KFEGKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPQF----TEMVDRANENVRVGGS---VSMWFHEMFPWVGPFLK-SKRIIVENIIQSRAQMTKLITALLETL-------NPNDPRGFVDSFLTRKLSDE-----------------------------------------KSGKKDSYFHEENLIMTVTNLFVAGTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDRVIG-GRQ------------------------------------------------------PVVEDRKKLPYTDAVIHEIQ-RLANIVPLSLPHKTTSDITFNGYFIKK------GTTVVPLLTSVLKDESEWEKPNSFYPE------HFLDEKG---------QFVKRDAFIPFSAG-----------RRVCLGE-SLARMELFLFFTSLLQSYRFTTPPGVSEDELDLKGIVG--ITLNPS--------PHKLCAIRRS------------------------------------------------------------------------ Danio_rerio_DrCYP2K20 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVVESLLQ-FASTS-ALLGALLLLLVLYLASSGST-SQKEGK-----------------------------EPPGPKPLPLVGNLLTLDL----------------TRSFDTFFELS------KTYGNIFQVFLGHRKTVVLVGYKTVKEALVNYA---EVFGDREIGPGFNDMVLCGSG---ILFSNGENWKEMRRFALSNLRDFGMGKRG-------SEEKIIEEIHHLKGEFD-------------KFEGKPFDTTQPVNYAVSNIISSIVYGSRFEYIDPRF----TEMVARANENVRVGGS---FSMMIYNIFPWLGPFLK-NRAVVVKNITQNRAEKKKLITALLETL-------NPHDPRGFVDSFLIHKLSDE-----------------------------------------KSGKKDSYFHEENLMLTVANLFAAGTDTTGTTLRWGLMLMAKYPHIQDRVQEEIDRVIG-GRQ------------------------------------------------------PVVDDRKKLPYTDAVIHEIQ-RLANIVPLSLPHRTTSDITFNGYFIKK------GTTVVPLLTSVLKDESEWEKPNSFYPE------HFLDEKG---------QFVKRDAFMPFSAG-----------RRVCLGE-SLARMELFLFFTSLLQSYRFTTPPGVSEDALDLKGIVG--ITLNPS--------PHKLCAIRRS------------------------------------------------------------------------ Danio_rerio_DrCYP2K21 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAVVESLLQ-FASTG-TLLGALLLFLVLYLVSSGSE-SQKEGK-----------------------------EPPGPKPLPLVGNLLTLDL----------------TRPFDTFFKLS------KTYGNVFQVYLGPEKAVVLVGYKTVKEALVNYA---EEFGDREIGPGFS-IMNDEHG---ILFSNGENWKEMRRFALSNLRDFGMGKRG-------SEEKIIEEIHHLKGEFD-------------KFEGKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPQF----TEMVDRANENVRVGGS---ISMWLYDIFPWLGPFLK-NKRIIVENIIQSRVQMTKLITALLETL-------NPNDPRGFVDSFLIRKLSDE-----------------------------------------KSGKKDSYFHEENLMMTVTNLFIAGTDTTGTTLRWGLMLMAKYPHIQDRVQEEIDRVIG-GRQ------------------------------------------------------PVVEDRKKLPYTDAVIHEIQ-RLANIVPLSLPHRTTSDITFNGYFIKK------GTTVVPLLTSVLKDESEWEKPNSFYPE------HFLDEKG---------QFVRRDAFMPFSAG-----------RRVCLGE-SLARMELFLFFTSLLQSYRFTTPPGVSEDELDLKGIVG--ITLNPS--------PHKLCAIRRS------------------------------------------------------------------------ Danio_rerio_DrCYP2K22 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNMALVGALLPGLSFTVGMVVAFLLLFLVISYFSSS----KDQGK-----------------------------YPPGPKPLPLLGNLHILDL----------------KNTYMSLWKLS------KQYGPVYTVHMGPRTVVVLSGYKAVKEALVNLS---EEFGERDISPIFQ-DFNEGYG---IVFSNGENWKEMRRFALSNLRDFGMGKKR-------GEELITEEIKYLKEEIE-------------RFGGKPFETKLPLAMAISNVIALIVYSIRFEYNSPKF----HRAIVRANENAKLVGS---PSVQLYNMFPWLRLFVI-NQKRVVDNVQESFKQIGEIVNGLKKTL-------NPQSPRGIADKFLIQQQKDK-----------------------------------------ESGKTDSLYNSNNFLTTINNLFGAGIDTTVTTLRWGLLLIAKYPEIQAKVHDEIDSVIG-ERQ------------------------------------------------------PVPGDRKNLPYTDAVIHEIQ-RFADILPIGLLRQTSCDVHLNGYLIKK------GTSVFPLIASVLRDENEWETPDSFNPK------HFLNKQG---------QFVKKDAFMPFGAG-----------RRLCIGE-SLARMELFLFFTSLLQHFCFTPPPGVSEDELDLTPVVG--FTLSPM--------PHKLCAVKRF------------------------------------------------------------------------ Danio_rerio_DrCYP2K31 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALVGALLPGLSFTVGMVVAVLLLFLFISFFSSS----QDEGK-----------------------------YPPGPKPLPLLGNLHILDL----------------KNTYMSLWKLS------KTYGPIYTVHMGPRKVVVLSGYKTVKEALVNLS---EEFGDRDISPIFH-DFNQGYG---IVFSNGENWKEMRRFALSNLRDFGMGRKR-------SEELIIEEIKQLKEEFE-------------KFRGKPFETKMPIAMAIANIIALIVYSIRFEYTNTKL----HCMIGRAYENARLTGS---PSVQLYNMFPWLRPFVA-NQKRIINNVKEAFKQSGEIMNGLKNTL-------NPQDPRGIADKFLIRQQMDE-----------------------------------------DSGKTDTYYNSNNLLSTINNLFGAGTDTTVTTLRWGLLIMAKNPEIQAKVQDEIKRVIG-DRQ------------------------------------------------------PVPDDRKNLPYTDAVIHEVQ-RFADVLPIGSPHQTTCDVHLNGYLIKK------GTSVCPLLASVLRDENEWETPDSFNPK------HFLNKQG---------QFVKKDAFMPFGAG-----------RRLCIGE-SLARMELFLFFTSLLQHFCFTPPPGVSEDELDLTPVVG--FTLNPI--------PHKLCAVKRS------------------------------------------------------------------------ Danio_rerio_DrCYP2N13 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAYTAMLETLDVKGILLFMVAFLLVADYLK-NKNPPK-----------------------------YPPSPFSVPLLGNIFNVDS----------------KEPHLYLTKLG------HAYNNIFSLRLGSDKTVFITGYKMVKEALVTQA---ENFVDRPNSPVLARVYSGN-A--GLFFSNGEMWKKQRRFALSTLRNFGLGKKT-------MELAICEESRFLLEEID-------------EQKGAAFDPTILLYNAVSNIICQMVFGQRFDYADHQF----KTMLKYISKSIQLEGS---VWGQIYEAFPAIMKHLPGPHNDIFSNYDLLKSFVHEVIVKHKAKL-------DPSEPRDYIDTFLIEMKEKP-----------------------------------------LERVN--GFEEPNLVACVLDLFLAGTESTSNTLCWGLIYLIMYPDVQEKVQEEIDRVIGNSRE------------------------------------------------------PSIADKPNMPYTEAVIHEIM-RFGDVIPLNGLRVAARDTTLGECFIPK------GTTVLPILHSVLFDENEWETPYKFNPG------HFLDKEG---------KFVRRDAFMPFSAG-----------KRVCLGE-QIARIELFLFFVSLFRKFRFSATEGEKLNMDGV---IG--ITRTPH--------PFKICATAR------------------------------------------------------------------------- Danio_rerio_DrCYP2P6 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDLLHIYEWIDIKAVLFFACVFLLLSNYIR-NKTPKN-----------------------------FPPGPWPLPIIGNLYHIDF----------------NKIHLEVEKLS------EKYGSVVSVHLFGQRTVILNGYKQVKEVYIQQG---DNVADRPELPMIHDIAGD-NG---LVAPSGYKWKQQRRFALSTLRNFGLGKKS-------LEPSINLECHYLNEAIS-------------NENGRPFDPHLLLNNAISNVICVLVFGNRFDYSDHHF----QTLLNDINEAMYLDGT---IWAQLYNSYPRIMRLLPGPHKKNITLWNKVIDFARERVKEHRVDY-------DPSNPRDYVDCFLAEMEKLK-----------------------------------------DDTAA--GFDVENLCICTLDLFVAGTETTSTTLSWSLLYMIKYPEIQAKVQEEIDRVIGSSRH------------------------------------------------------PSVSDRDNMPYTNAVIHEIQ-RFGNIAALNLPRAAVKDIQVGKYLIPK------GTIVIGNLTSVLFDESEWETPHSFNPG------HFLDAEG---------KFRRRDAFLPFSLG-----------KRVCLGE-QLARMELFLFFTSLLQHFTFSSPAGVEPSFNYK---LG--TTRAPK--------PFKLCAVSR------------------------------------------------------------------------- Danio_rerio_DrCYP2P7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDVLQFYKWLDIKTVLVFLVVFLFLSDYIR-NKSPKN-----------------------------FPPGPWSLPFIGHIHHIEH----------------KKVHLQFLKFA------EKYGKIFSIRLFGPRIVVLDGYKLVKEVYLQQG---DNLADRPILPMFYDITED-KG---LIGSNGYKWKHQRRFALSTFRTFGLGKKS-------LEPSILLECSCLNDAFS-------------NEQGRPFDPRLLLNNAVSNVICALVFSNRFDYSDHHF----QTLLKHINEVLYLEGT---VWAQLYNFFPWLMRRLPGPHQKIFVLLNKVIDFVREKVNEHRVDY-------DPSNPRDYIDCFLAEMEKLK-----------------------------------------DDTAA--GFDVENLCICTLDLFVAGTETTSTTLYWGLLYIIKYPEIQAKVQQEIDAVVGGSRQ------------------------------------------------------PSVSDRDNMPYTNAVIHEIQ-RMGNIVPLNVFRITVEDTQIGEYSIPK------GTLVIGSLTSVLFDESEWETPHSFNPG------HFLDAEG---------KFRRRDAFLPFSLG-----------KRVCLGE-QLARMELFLFFSSLLQRFTFSPPAGVEPSLDYK---LG--GTHSPQ--------PYKLCAVPR------------------------------------------------------------------------- Danio_rerio_DrCYP2P8 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDLWYLYEWIDIKSILIFLCVFLLLGDYIK-NKAPKN-----------------------------FPPGPWSLPIIGDLHHIDN----------------SKIHLQFTKFA------ERYGNIFSFRLFGPRIVVLNGYNLVKEVYIKQG---DNLADRPVLPLFYEIVGD-KG---LILSSGYKWKHQRRFALSTLRNFGLGKKS-------LEPSINVECGFLNEAIS-------------NEQGRPFDPRLLLNNAVSNVICVLVFGNRFDYSDHHF----QTLLKNISEAVYLEGS---ICNQLYNMFPWLMERLPGPHKTIITLWRKVTDFVREKVNEHRVDY-------DPSNPRDYIDCFLTEMEKLK-----------------------------------------DDTAA--GFDVENLCICSLDLFVAGTETTSTTLYWGLLYMIKYPEIQAKVQEEIDAVVGGSRQ------------------------------------------------------PSVSDRDNMPYTNAVIHEIQ-RMGNIAPINLARSTSEDTQIGNYSIPK------GTMVTSNLTSVLFDESEWETPHSFNPG------HFLDAEG---------KFRRRDAFLPFSLG-----------KRVCLGE-QLARMELFLFFSSLLQRFTFSPPAGVEPSLDYK---MG--GTHCPK--------PFKLCAVPR------------------------------------------------------------------------- Danio_rerio_DrCYP2P9 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDLWDLYEWIDIKSILIFLCVFLLLGDYIK-NKAPKN-----------------------------FPPGPWSLPIIGDLHHIDN----------------SKIHLQFTKFA------ERYGNIFSLRLFGPRIVVLNGYNLVKEVYIKQG---DNLADRPVLPLFYEIIGD-KG---IVLSSGYKWKHQRRFALSTLRNFGLGKKS-------LEPSINLECGFLNEAIS-------------NEQGQPFDPRLLLNNAVSNVICVLVFGNRFDYSDHHF----QTLLKHINEAIYLEGG---ICAQLYNMFPWLMQRLPGSHKKVITLWKKVIDFIRQKVNEHRVDH-------DPLNPRDYIDCFLAEMDKLK-----------------------------------------DDTAA--GFDVENLCICTLDLFVAGTETTSTTLYWGLLYMMKYPGIQAKVQEEIDRVVGGSRQ------------------------------------------------------PSVSDRDNMPYTNAVIHEIQ-RMGNIIPINVTRTTSEDIRIGKYSVPK------GTMVTSNLTSVLFDESEWETPHSFNPG------HFLDAEG---------KFRRRDAFLPFSLG-----------KRVCLGE-QLARMELFLFFSSLLQRFTFSPPAGVEPSLDYK---LG--ATHCPQ--------PYQLCAVPR------------------------------------------------------------------------- Danio_rerio_DrCYP2P10 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDMFYFYEWVDIKSILIFLCVFLLLSDYIK-NKAPKN-----------------------------FPPGPWSLPFIGDLHHIDP----------------NKIHLQFTEFA------EKYGKIFSFRLFGSRIVVLNGYNLVKEVYTQQG---DNLADRPTLPITSAIIGDNRG---LVASSGYKWKHQRRFALTTLRNFGLGKKN-------LELSINFECGFLNEAIS-------------NEQGRPFNPRLLLNNAVSNVICVLVFGNRFEYSDHHF----QNLLNKINESVYLEGS---IFVHLYNMFPWLMQLLPGPHKKLITLWQRVTDFVREKVNEHRVDY-------DPSSLRDYIDCFLAEMEKHK-----------------------------------------DDTAA--GFDVENLCMCTLDLFVAGTETTSTTLYWGLLYMIKYPEIQAKVQQEIDAVVGSSRQ------------------------------------------------------PSGSDRDNMPYTNAVIHEIQ-RMGNIIPLNVVRTTSEDTRIEKYSIPK------GTLVIGSLTSVLFDESEWETPHSFNPG------HFLDAEG---------KFRRRDAFLPFSLG-----------KRVCLGE-QLARMELFLFFSSVLQRFTFSPPAGVEPSLDFK---MG--FTRCPK--------PYKLCAVPR------------------------------------------------------------------------- Danio_rerio_DrCYP2R1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MISIKRLTSPLSLSWEQTLICLLGLFTTLLILLVIRQLVKQRRPRG-----------------------------FPPGPTPLPIIGNMLSLAT----------------EP-HVYMKRQS------DIHGQIFSLDLGGIPTVILNGYDAIKECLYHQS---EVFADRPSLPLFQ-KMTKMGG--LLNCKYGRGWIEHHKLAVNCFRYFGTGQRM-------FER-ISEECLYFLDAID-------------QHQGKPFNPKHLVTNAVSNITNLIIFGQRFTYDDGDF----QHMIEIFSENVELAAS---SWAFLYNAFPWMEYLPFGKHQRLFRNANEVYKFLLQIIRRFSQGR-------VPQSPQHYIDAYLDEMEQST-----------------------------------------PDKAT--SFSQDNLIFSVGELIIAGTETTTNCLRWAMLYMALYPRIQEKVQMEIDSVL-NGRQ------------------------------------------------------PAFEDRQRMPYVEAVLHEVL-RLCNIVPLGIFRATSQDAVVRGYTIPK------GTMVITNLYSVHFDEKYWSDPSIFCPE------RFLDCNG---------KFIRHEAFLPFSIG-----------KRHCLGE-QLARLEMFLFFTTLLQRFHLQFSEGFIPSLSAK---LG--MTLQPQ--------PYSICAIRRQQ----------------------------------------------------------------------- Danio_rerio_DrCYP2U1 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRSAPVMDVSAGLLLEYVFSPANIAGLIAFVLVFYVLQEYQWHQT-YAN----------------------------IPPGPKPWPIVGNFGGFLVPPFILKRFVKNSKEFAKVVSNPLSPQAGLIEMSKLYGNIFSIFVGPQLMVVLTGYDAVRDAMLNHT---ETFSDRPHIPLVT-IITKRKG--IVFAPYGPLWRTNRRFCHSTLRSFGFGRMS-------LEPCIHEGLAIIKTELQSLIE---------TAGPSGIDLTPLISNAVSNIISLMSLGQRFHHEDKEF----RNMRDLMSHGLEISVN---TSILLVNVFPWLYYLPFGVFKELRRAELDITAFLKRIIARHRATL-------DPENPRDFIDMYLVEMLAKQK----------------------------------------EGSSEENLFSEDDLFYIIGDLFIAGTDTTTNSMLWSILYMSLYPDVQEKVQKEIDAVVGSERV------------------------------------------------------PSLTDKSSLPYTEATIMEVI-RMTVVVPLSIPHMASETTEFRGFTIPK------GTVIIPNLWSVHRDPTVWENPDDFNPS------RFLDDQG---------KILRKDCFIPFGLG-----------RRVCMGE-QLAKMELFLMFTSLMQTFTFRFPEGATAPSMHGR--FG--LTLAPC--------PFTVCVKTR------------------------------------------------------------------------- Danio_rerio_DrCYP2V1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALENILLHLNSKVWTDAGTILLLFILFLLVSVKLRNRNKPHKN----------------------------LPPGPTPLPFIGNVFNLDT----------------SQPHIDLTKMS------DHYGNIFSLRLGSLNTVVVNTYSMVKKVLNDQG---NSFMYRPVNDITERISKC-QG---LTFNNGYSWKQHRRFTLSTLKFFGVGKRS-------LEFIIMEEYKFLHQSIM-------------DTNGLPFNPHYIINNGVSNIICSMVFGRRFEYTDQRF----LNMLSLISKALKLQTS---VFIQLYAAFPRLMDLLPGPHKELFSCFHQVRAFIKEEVDKHRADW-------DPSSPRDFIDCYLTEIEKKK-----------------------------------------DDLEA--GFHDEGLQYAVLDLFVAGTETTSTTLLWAFVYMMKYPEIQEKVQAEIDKVVGRYRR------------------------------------------------------PSMDDRPCMPYTDAVIHEIQ-RMGNVVPLSVPRMTNEDTILEGYFIPK------GTQIIPNLTSVLFDQTKWKTQHSFDPQ------NFLNAQG---------KFEKPEAFIPFSLG-----------KRSCPGE-SLARMELFLFFTSFLQSFSLSAPDETQTSLDFK---FG--MTLSPK--------PFKICFTPR------------------------------------------------------------------------- Danio_rerio_DrCYP2X6 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFCDCSWTTVSMLGSSLLVVICILLIFFLIRVKKPKN-----------------------------FPPGPPPVPIFGSLLQLNL----------------ANPLKDFEKFA------EKYGEIFSLYTGSRPAVILNSFAVIKEALVTKA---QDFSGRPQDFMIS-HATENKG--IVLADYGPVLKGHRRFALMTMRNFGLGKQS-------MEERILGEISHVVDYLD-------------KNAGKRVDPHIMFHNVASNVISLLLFGCRFDYNSEFL----QCYIQLINEISKIING---PWNMIYDTFP-LLRILPLPFKKAFDHVKVIKSMNLKLIDEHKSTR-------VPGEPRDFIDCYLDELDKGK-----------------------------------------NCVST---FSEDKLLMSIMDLHFAGTDTISNTLLTAFLYLMNHPEVQVKCQQEIDDVLEGKDR------------------------------------------------------VMYEDRHNMPYTLAVIHEVQ-RVANTVPLSVFHSTTRDTELMGYSIPK------GTIIIPNLTRVLKEEGQWKFPYEFNPA------NFLNEQG---------QFEKPEAFIPFSTG-----------LRMCLGE-GLARMELFLIFVALLRRFQFEWPVDAGKPDYTP--VFG--LTLTPK--------PYRMHIRRRETVKQ-------------------------------------------------------------------- Danio_rerio_DrCYP2X7 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLYKLVSLVLNKGTAVRMLEVSVLILICIFLVFFLIRIKRPKN-----------------------------FPPGPPPVPIFGNLLQINM----------------VDPLKEFERLA------EKYGNIFSLYTGSKPAVFLNNFEVIKEALVTKA---QDFSGRPQDLMIS-HLTGNKG--VVLADYGPLWKDHRRFALMTLRNFGLGKQS-------MEERILGEISHIVDFLD-------------KNTGKTVDPQIMFHNIASNVINLVLFGCRFDYNNEFL----RGYIQRIAENLRILNG---PWNMIYDTFP-LLRILPLPFKKAFDNVKIIKSMNRKLIDEHKSTR-------VPGQPRDFIDCYLDELDKVK-----------------------------------------NCVST---FSEDQLIMNIMDMSFAGTDTTSNTLLAAFLYLMNHPEVQVKCQQEIDDVLEGKDQ------------------------------------------------------VTYEDRHNMPYTLAVIHEVQ-RVANIVPLSVLHCTTRDTELMGYSIPK------GTVIIPNLTVVLKEEGQWKFPHEFNPA------NFLNEQG---------QFEKPEAFIPFSTG-----------PRVCLGE-GLARMELFLIFVTLLRRFQFVWPEDAGKPDYTP--VFG--LTMTPK--------PYRMHIRRRDTVKQ-------------------------------------------------------------------- Danio_rerio_DrCYP2X8 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLGSSVLVLICILLVFLLIRIQRPKN-----------------------------FPPGPSPLPIFGNLLHFNL----------------ANPLKDFERFA------EKYGNIFSLYTGSRPAVFLNSFAVIKEALVTKA---QDFSGRPQDFMIS-HLTECKG--VVLADYGPLWKDHRRFALMTLRNFGLGKQS-------MEERILGEISHVVCYLD-------------KNIGKTVDPQVMFHNVASNVISLVLFGRRFDYNSETL----QCYIQLITEISKILNG---PWNMIYDTLP-FLRILPLPFKKGFDHVKVLKGMNLKLIDEHKSTR-------VPGKPRDFIDCYLDELDKRK-----------------------------------------NEVST---FSEDQLLMYILDLYFAGTDTTSNTLLTAFLYLMNHPEVQVKCQQEIDDVLEGKDQ------------------------------------------------------VSYEDRDNMPYTLAVIHEVQ-RVANTVPLSVFHCTTRDTELMGYSIPK------GTLIIPNLTIVLKEEGQWKFPHEFNPA------NFLNEQG---------QFEKPEAFIPFSTG-----------FKSRI---------------------------------YT----TG--FTFN------------SFQFLRKKNK---------------------------------------------------------------------- Danio_rerio_DrCYP2X9 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLGFLILVWICIVLLFLFIQIPRPKN-----------------------------FPPGPRPLPLFGNLLELNI----------------NNPLKDFERLA------NRYGNIYSLYFGSKPWVVLNGFEALKEALVTKA---VDFAGRPQDLMVN-RVTKGGG--VILSDYGPSWKEHRRFALMTLRNFGLGKQS-------MEERILGEVSHIIDKLE-------------KRVGTAFDPQTMFHNAASNIICIVLFGSRYDYDDEFL----KLFIHLYTENAKIANG---PWAMIYDTFP-MFRYLPLPFRKAFANASKARELSTQLVKEHKKTW-------VPGEPRDFIDCYLDELDKRG-----------------------------------------NDGSS---FSEAQLILYVLDLHFAGTDTTSNTLLTGFLYLMTHPEVQAKCQQEIDDVLEDKDQ------------------------------------------------------ASYEDRHSMPYTQAVTHEVQ-RVANTVPLSVFHCTTKDTELMGYNIPK------GTFVIPNLGSALKEEGQWKFPHEFNPA------NFLNEQG---------EFEKPEAFVPFSAG-----------PRVCLGE-GLARMELFLVMVTLLRRFQFVWPNDAGKPDYTP--VYG--VTLTPQ--------PYRMHIKRRETVRI-------------------------------------------------------------------- Danio_rerio_DrCYP2X10.1v1 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLTALVLLCLGAFLLYLQLRIRRPKN-----------------------------FPPGPAPVPIFGNLLQLNR----------------ISPLKDFDKFA------QHYGSIYGIYIGSQPAVVLTGQKMIKEALITQA---AEFSGRSNNMMFS-HVTGGKG--VIMADYGESWREHRRFALTTLRNFGLGKKS-------MEQRILEEVKHICLLLE-------------ESAGKSIDPQHLYHQAASNIIASVIFGSRFNYKDAYF----QTLITSVEDLTKITIG---PWAMLYEIAP-VLRIFPLPFQKAFQYFEQITKHVLKVVEEHKTSR-------VAGEPRDLIDCYLEEMENKS-----------------------------------------DHRTS---FDESQMVTLLFDLFIAGTETTSNTLRTLTLYLMTYTHIQEQCQREIDEVLGARDH------------------------------------------------------VTYEDRNAMHFVQAVIHEGQ-RVADIAPLSMFHSAKTDTQLRGYSIPK------GTIIIPYLSSSLREEG------------------------------------------------------------VCY--------------------------------------------ISSIK--------QY---------YEDLVFV---------------------------------------------------------------- Danio_rerio_DrCYP2X10.2v2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLTALVLLCLGAFLLYLQLRIRRPKN-----------------------------FPPGPAPVPIFGNLLQLNR----------------ISPLKDFDKFA------QHYGSIYGIYIGSQPAVVLTGQKMIKEALITQA---AEFSGRSNNMMFS-HVTGGKG--VIMADYGESWREHRRFALTTLRNFGLGKKS-------MEQRILEEVKHICLLLE-------------ESAGKSIDPQHLYHQAASNIIASVIFGSRFNYKDAYF----QTLITSVEDLTKITIG---PWAMLYEIAP-VLRIFPLPFQKAFQYFEQITKHVLKVVEEHKTSR-------VAGEPRDLIDCYLEEMENKS-----------------------------------------DHRTS---FDESQMVTLLFDLFIAGTETTSNTLRTLTLYLMTYTHIQEQCQREIDEVLGARDH------------------------------------------------------VTYEDRNAMHFVQAVIHEGQ-RVADIAPLSMFHSAKTDTQLRGYSIPK------GTIIIPYLSSSLREEGQWKFPHEFNPQ------NFLNEKG---------EFVKNDAFMPFSAG-----------PRVCLGE-NLARMELFLILVTVLRRFRLVWPKDAGEPDFTY--IYG--GTQSVK--------PYRVIVEPRMHGEACKFVD--------------------------------------------------------------- Danio_rerio_DrCYP2X12c1 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLTALVLLCLGAFLLYLQLRIRRPRN-----------------------------FPPGPAPVPIFGNLLQLNH----------------INPIKDLDKFA------QHYGSIYGIYIGSKPAVVLTGQKMIKEALITQG---AEFAGRSNKMMVS-HVTRSKG--VIMADYGESWREHRRFALTTLRNFGLGKKS-------MEQRILEEVKHICLLLE-------------ESAGKPIDPQHLYHQAASNIIASIIFRSRFDYQDEYF----QTLITTMEKLTKIAIG---PWAMLYEIAP-VLRIFPLPFHKAFQYFEQITNHVLKVVEEHKTSR-------VAGEPRDLIDCYLEEMNRRS-----------------------------------------DKHTT---FDESQMVTLLFDLFIAGTETTSNTLRTLTLYLMTYTHIQEQCQREIDEVLGARDH------------------------------------------------------VTYEDRNAMHFVQAVIHEGQ-RVADIVPLSMFHTARTDTQLRGYSIPK------GTIIIPYLSSSLREEGQWKFPHEFNPQ------NFLNEKG---------EFVKNDAFMPFSAG-----------PRVCLGE-NLARMELFLILVTVLRKFRLVWPKDAEEPDFTY--IYG--GTQSLK--------PYPMIVKLRTPGETHEYAK--------------------------------------------------------------- Danio_rerio_DrCYP2X12c2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLTALVLLCLGAFLLYLQVRIRRPKD-----------------------------FPPGPAPVPFFGNLLQLNR----------------INPIKDLDKFA------QHYGSIYGIYIGSKPAVVLTGQKMIKEALITQA---AEFAGRPNHMMIS-HITRSKG--VIMADYGESWREHRRFALTTLRNFGLGKKS-------MEQRILEEVKHICLLLE-------------ESAGKSIDPQHLYHQAASNIIASVIFGSRFNYKDEYF----QTLIQTMEKLTKIAIG---TWAMLYEIAP-VLRIFPLPFWKAFHYFEKITRHSLKVVEEHKKSF-------VAGEPKDLIDCYLEEMKKRA-----------------------------------------DQRTT---FDEAQMVTLLFDLFLAGTETTSNTLRTLTLYLMTHTHIQEQCQREIDEVLGARDH------------------------------------------------------VTYEDRNDMHFVQAVIHEGQ-RVADIVPLNVFHTARTDTQLRGYSIPK------GTIIIPYLSSSLREESQWKFPHEFNPQ------NFLNEKG---------EFVKNEAFMPFSAG-----------PRVCLGE-NLARMELFLILVTVLRKFRLVWPKDAGEPDFTY--IYG--GTQSLK--------PYPMIVELRTPGETHEYAN--------------------------------------------------------------- Danio_rerio_DrCYP2Y3 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MELSSSLLLVLVLTVLMLIRWRRKE---NGLS-----------------------------LPPGPLALPLIGNLLTLDK----------------SAPFKSFMKWR------KTYGSVMTVHLGPQRMVVLVGYETVKEALVDQA---DDFAPRAPIPFMN-RIVKGYG---LAISNGERWRQLRRFTLTTLRDFGMGRKR-------MEQWIQEESRYLLKSFE-------------ETKSKPVDPTFFFSRTVSNVICSLVFGQRFDYEDKNF----LQLLQIISKLLRFLSS---PWGQLYNIFPQVMERFSSRHHAILKDVENIRTFIRSKVKEHEQRL-------DFSDPSDFIDCFLIRLTQEK-----------------------------------------D--KLDTEFHKDNLMATVLNLFVAGTETTSTTLRYALMLLIKHPQIQEQMQREIDRVIGQNRI------------------------------------------------------PTMEDRKSLPFTDAVIHEVQ-RYMDIVPLSLPHYAMKDITFRGYKIPK------DTVIIPMLHSVLRDEGQWETPWTFNPE------HFLDSNG---------NFQKNPAFMPFSAG-----------KRSCVGE-SLARMELFLFTVSLLQKFTFSSPNGP--DGIDLSPELSS-FANMPR--------FYELIASPR------------------------------------------------------------------------- Danio_rerio_DrCYP2Y4 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MELSSSLLLVLVLTVLMLIRWRRKE---NGLS-----------------------------LPPGPLALPLIGNLLTVET----------------SAPFKSFMKWS------KSYGPVMTVHIGTQRMVVLVGYETVKEALVDQA---EDFASRAPIPFTN-RVLRGYG---LIISNGERWRQLRRFTLTTLRDFGMGRKR-------MEQWIQEESRYLLKSFE-------------ETKSKPVDPLFFMSRAVSNVICSLVFGQRFDYEDKNF----LQLLQIISNLMRFASS---PWGQLYNIFPKVMEILPGRHHTMFGEIDDLKSSIMTIIKEHEENL-------DPSDPKDFIDCFLIRLNQEK-----------------------------------------H--NPDTEFHKENMFATSLNLFTAGTETTSTTLRYALMLLIKHPHIQEQMQKEIDCVIGQNRI------------------------------------------------------PTMEDRKSLPFTDAVIHEVQ-RCLDIAPLNVPHYALKDITFRGYKIPK------DTVIIPMLHSVLRDEGHWETPWTFNPE------HFLDSNG---------NFKKNPAFMPFSAG-----------KRVCVGE-SLARMEIFLFIVSLLQKFSFSSPNGP--DSIDPSPELSS-FGNMPR--------LYELIASPR------------------------------------------------------------------------- Danio_rerio_DrCYP3A65 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFFSAETWTLLAFLAALLVIYGSWPHRYFKKL----------------------------GIPGPKA-IPFFGTMLRYKDG------------------FHVFDMDC-----FEKYGRIWGIYDGRQPVLCIMDQTIIKTVLIKEC-----YSLFTNRR--NFRLNGALYDAVSIAE-DDDWRRIRSVLSPSFTSGRLKEMFG------IMKKHSHILVDSMGKTAK--------------RGESADIKEFFGAYSMDVVTSTAFSVDIDSLNNPK----DPFVTNIKKMLKFDLLNPL-FLLIAFFPFMAPVLEKMDFALFPTSVTDFFYAALQKIKSDRDTKTV--AKDNTKKRVDFLQLMVDSQTGVKHK-----------------------------------SDG---EHTEKGLSDHEILSQSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETFPNQA------------------------------------------------------PVDYETLMSMDYLDAALSESL-RLFPVAARLERVCKKTVEIN-GLLIPK------DLVVMVPTYALHRDPDYWSEPESFKPE------RFTKGNK---------ESIDPYMYMPFGLGP-----------RNCIGM-RFAQVTMKLAIVEILQRFDVSVCDETQVP-----LELGFNGLLSP-------KDPIKLKLQPRKLSQSPDVCNNNQKS---------------------------------------------------------- Danio_rerio_DrCYP3C1 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFDLSSLSVT-WTLVVLVITLLLIYGVWPHGFFKKL----------------------------GIPGPRP-LPFVGTALSYSKG------------------ICNFDIEC-----SKKYGKVWGIYDGRLPLLLVTDLEMIKTILVKDC-----YSTFTNRRNMNPDLVGPFADGITLVK-DERWRRIRSSLSPYFTSGRLKEIFP------IAMTHADRFIKNMEKKDP---------------NLPLKIKDVVAPYSLDVVASSSFSVDFDSINNPD----DPFVTSIKSFFNINPLSPL-FLLLAFCPSAANLLAKMGISVFSRSTTDFYYKALRKIKDEH---------NESNGRVDFLKLMIQNQIPDDQV-----------------------------------KDT-ASEQPVKGLTDHEILSQSFIFILGGYETTSTTLSYLLYNLATNPDCLEKLVEEIDKNFPLDI------------------------------------------------------PITYDALMRMDYLEMAIHESM-RVFPAGPRLERVCKKTVEIN-GITIPK------NTLVGIPLYVLSRDPDLWESPNEFKPE------RFSPESK---------TEINQCAFMPFGLGP-----------RNCIGM-RFALMMMKLLVVKLLQKYTVETCKETQIP-----VQLNFF--FQP-------KVPITLKLIPRSHKEKQ------------------------------------------------------------------- Danio_rerio_DrCYP3C2 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEC-----AKKYGKVWGIYDGRLPILMVTDLEMIKTIMVKEC-----YSTFTNRREINVDLAGPLADGITAVK-DERWKRIRGTLSPYFTSGRLKEIFP------IAMTHADRFIKNMQKGDH---------------EQPVKIKEVMASYSLDVVTSSAFSVDIDSINNPD----DPFVTNIKNFLKFNLFGLF-VLLLTVFPSIANLLGKMGLSMFSKPTVDFFYKALRKIKEEH---------KDSNGRVDFFRLMIQNEIPDDQV-----------------------------------KDT-TSEQPEKGLTDHEILSQSFIFIMGGYETTSTTLTFLLYNLAINPDCLEKLVEKIDKNFPLDT------------------------------------------------------PISYDALMKIDYLEMSINESM-RLLPTAPRLERVCKKTVEMN-GITIPK------DTMITIPTYVLNQDPQLWDSPHEFRPE------RFSPENK---------SEFLQYAFMPFGLGP-----------RNCIGM-RYALMIVKLLVVKLLQNFSVETCKETQIP-----LELNPV--FQP-------KVPITLKLTPRKRNN--------------------------------------------------------------------- Danio_rerio_DrCYP3C3 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIDLSSLSVT-WTLVFLVITLLYMYGVWPHGFFKKL----------------------------GIPGPRP-WPFFGTFLSYTKG------------------FFNFDMEC-----AKKYGKVWGIYDGRLPILMVTDLEMIKTIMVKEC-----YSTFTNRREVNVDLAGPLADGISAVK-DERWKRIRGTLSPYFTSGRLKEIFP------IAMTHADRFIKNMQKRDH---------------EQPVKIKEVVAPYSLDVVTSSSFSVDIDSINNPD----DPFVTNIKNFLKFSLFSPL-ILFLTLFPSIANLLGKMGISVFSRSIMNFFYTALRKIKDEH---------KDSNGRVDFLRLMIQNQIPDDQA-----------------------------------KDT-TSEQPVKGLTDHEILSQSFIFILGGYETTSTTLSFLLHNLATNPDCLEKLVEEIDKNFPLDT------------------------------------------------------PISYDALMKMDYLEMSINESM-RLLPTAPRLERVCKKTVELN-GITIPK------DTLVAIPTYVLNRDPQLWDSPQEFRPE------RFSPENK---------SEFLQYAFMPFGLGP-----------RNCIGM-RFALMIVKLLVVKLLQNFSLETCKETQIP-----LELTPV--FQP-------KVPITLKLTPRKRNN--------------------------------------------------------------------- Danio_rerio_DrCYP3C4 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIDLSFLSVT-WTLVVLVITLLFIYGVWPHRFFIKL----------------------------GIPGPRP-WPFVGTLLSYAKG------------------LCNFDMEC-----AKKYGKVWGIYDGRLPILMVADLEVIKVVLVKEC-----YSNFINRRKRTTGLAGPFSDGIIMVK-DERWKRMRSTLSPYFTSGRLKEIFP------IAMTHADRFIKNMQKKDP---------------EQPVKIKEVVAPYSLDVITSSSFSVDIDSINNPE----DPFVINVKKFIQFNMFNPL-LLLILLFPSLAIPLKKMGVTLFSKSAMDFFYSVLKKIKDDHN--------KESEGRVDFLKLMLQNQIPDDQI-----------------------------------QDSDTSEQPAKGLTDHEILSQSLVFILGGYETTSTTLTFLLYNLATNPDCLEKLVEEIDKNFPLDT------------------------------------------------------PITYDALMRMDYLEMAINESM-RLLPTAPRLERSAKKTVVIN-GLTIPE------GTLVGIPTYVLSHDPDIWESPGEFRPE------RFSPENK---------SEFLQYAFIPFGLGP-----------RNCIGM-RYAVMIMKLFVVKLLQNFSVETCKETQIP-----LEMNVT--FQP-------KVPITLKLIPRSCNKKQ------------------------------------------------------------------- Danio_rerio_DrCYP4F3 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMLFG------LSVTGILALS------VAALLCALVTRIIIN----RRALR----------------------------CFNQPPLRNWIMGHMGLMGHN------------EEGLQRVDDLVCKY-----GHS---CSWFLGPFYNMVRLFHPDYIRSLLTASAS-ITLKDRIFYGFMKP-----WLGNCLLLQS-GQEWSRHRRLLTPAFHFDILKKYVH------IFNQSTNIMHDEWRRLLAKG-------------EHSVDMFEQISSLTLDSLLKCTFSCDTHSQEKP--RQYISAILDLSRLLVQRQHYLPYHWDWLYWRSAQGRRFQQACAVVHQFTADIVQERRTQLDQQSDPESHPENTGRYRKRKNTDLIDLLLLAKDDKG---------------------------------------------EGLTNEEIKAHADMFMFAGHDTTASALSWIFYNLAMNQDYQERCRAEVRDLLADRDTH----------------------------------------------------TIGWEDLSQLTFTTMCIKESL-RLHSPVLALTRYYSQNMKTPGDCVIPH------GCLCLISIYGVHRNPQVWPDPLVFDPT------RFDPHNS---------DSRSPHAFIPFSAGP-----------RNCIGQ-NFAMAEMKVVVALTLARFKILPGPKP--------VRRLYQLVLRAE-------GGMILHFQELNEE---------------------------------------------------------------------- Danio_rerio_DrCYP4T8 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLLYGISPFVLSVNHVFA---LIFLACLLTVVKLLIVRRKG-VKTME----------------------------RFPGPPA-HWLFGHVKEFRQD------------GHDLEKIVKWMELY-----QFA---FPLWFGPSLAVLNIHHPSYAKTILTTTE----PKDDYAYKFFIP-----WLGDGLLVST-GQKWFRHRRLLTPGFHYDVLKPYVK------LISDSTKVMLDKWEVHSRS--------------EESFELFKHVSLMTLDSIMKCAFSCNSNCQTDSGTNPYIQAVFDLCHLVNLRFRVFPYHSKAIFHLSPHGYRFRKAASIAHNHTAEVIRKRKEVLKMEEE-------QGIVKNRRYLDFLDILLSARDEHQ---------------------------------------------QGLSDEDIRAEVDTFMFEGHDTTASGISWIFYNLACNPEHQEKCRQEIQQALDGKD------------------------------------------------------TLEWEDLNKIPYTTMCIKESL-RLHPPVPGISRKLTKPLTFFDGRTVPE------GCTIGVSIYGIHMNSTVWENPYKFDPL------RFLPENA---------ANRSPHAFVPFSAG---------------------------------------------------------PRFVTRSV------------------------------------------------------------------------------------------ Danio_rerio_DrCYP4V7 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------MCASFQSVSYGQLHPNKMGILFGLYILGILFTAVLLLLLASTAYNPLKNYIGKWNEMR----------------------------PIPGMAGAYPIIGNALQFKTNA-----------GDFFNQIIEGTNEN-----RHLP-LAKVWVG-PVPFLILYHAENIEVVLSNSR---HLDKSYSYRFLHP-----WLGTGLLTST-GEKWRNRRKMLTPTFHFSILSDFLE------VMNEQTDILIQKMQKLEDG---------------EPFNCFNFITLCALDIICETAMGKKIYAQSNAD-SEYVQSVYKMSDIITKRQRAPWLWPDWIYNKLKEGKEHAKRLKILHSFTANVIRERAEFMSS-EPDSD-----SDQGERKRQAFLDMLLKTTYENG---------------------------------------------QKLSHEDIQEEVDTFMFEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEVFGSSER-----------------------------------------------------HVGVEDLKKLRYLECVIKESL-RIFPSVPLFARSICEACHIN-GFKVPK------GVNAVIIPYALHRDPRYFPEPEEFQPE------RFMPENS---------KGRHPYAYIPFSAGP-----------RNCIGQ-RFAMMEEKVVLATILRHFDVEACQSREE------LRPLGELILRPE-------KGIWIKLQRRSK----------------------------------------------------------------------- Danio_rerio_DrCYP4V8 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVAFVGVYTYGFVAASVCVICFAYITYQLLKSYLHKWKELK----------------------------PIPGIGNTFPFIGNALQFKSN------------GDFFLQLVGYTTEF-----QNSP-LLKIWIG-PIPFLILFHAETVETVLNNPV---HIDKAYAYQFLHP-----WLGTGLLTST-GDKWRRRRKMLTPTFHFSILTEFLE------VMNEQAEVLIEKLEKQAGK---------------GPFNCFSHITLCALDIICETAMGKRIYAQSNYD-SEYVRTVYRMSDIITRRQRMPWYWPDFVYNYVGEGREHNRSLKILHSFTESVINERAEYLSYVESDSE-----SDQGMRKRRAFLDMLLKTKDEDG---------------------------------------------KMLTHKDIQEEVDTFMFEGHDTTAAAMNWAIHLLGSHPEVQRKAQQELFEVFGESER-----------------------------------------------------PVNTEDLKKLRYLECVIKESL-RLFPSVPFFARTICDDTQIN-GFKVPK------GTNIVVITYALHRDPRFFPDPEEFRPE------RFLPENC---------VGRHPYAYIPFSAGL-----------RNCIGQ-RFAIMEEKVILAYILRYFNIVACQKREE------LRPLGELVLRPE-------QGIWITLERRKLTMS-------------------------------------------------------------------- Danio_rerio_DrCYP5A1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQLLVDGLKWFGVEASGLSLTVCLFLLSLSLLYWYSISPFSNLERC----------------------------GIKHPKP-LPFIGNLMMFRNG------------------FFKSQADL-----INKYGRICGYYIGRRSTVIIADPDMLRQVMVKE------FNKFPNRMTARGITKPM-SDSLIMLK-GEQWKRVRSILTPTFSAAKMKEMVP------LINTATETLLRNLKSHAE--------------SENSFNIHKCFGCFTMDVIASVAFGTQVDSQNNPD----DPFVHQASKFFAFSFFRPIMIFF-MAFPFLLRLLAGLLPNKSRDEMNSFFTQCIQKMIKQRDD------LSPEQRRKDFLQLMLDVRTNKKFLSVEHFDVVNDADEEAYDG-----------HENSPANESTKRSQQKRMMTEDEIVGQSFIFLVAGYETSSNTLAFTCYLLAVHPECQKKLQEEVDEFFSRHE------------------------------------------------------TVDYANVQELKYLDMVICESL-RLYPPAFRVARDVEEDTVLN-GQFLPK------GASLEIPTGFLHYDPEHWTEPTKFIPE------RFTPEAK---------ARRHPFVYLPFGAGP-----------RSCVGM-RLAQLEIKVALVHIFRRFNVLACEDTEIP-----LELKSHTTLGP-------KNGVMVKITERENLEDAS------------------------------------------------------------------ Danio_rerio_DrCYP7A1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MILTISFIWAIVVGLCC-------------------------CLWLITGIRRRHPAEPPLENGWIPFLGCALQFGAN-----------------PLEFLRSRQ------KKHGHIFTCKIAGQYVHFLCDPFSYHAVIRQGRH-------LDWKKFHFDASAKAFGHESMDPSQGYTTENLHQTFLKTLQGDALSSLI---------ETMMENLQGTMLQSGM-----------LKATT-SEWQSDGIYAFCYKVMFEAGYLTLFGKELDGD--------QSIA----RQQAQKALVLNALDNFKEFDKIFPALIAGLPIHVFKSAYSAREKLAKTMLHE--------NLSRRANVSDLISLRMLL--------------------------------------------NDTLSTFNELSKARTHVAILWASQANTLPATFWTLFHMIRCPAAMKAASEEVRRTFESSNQKVDPTNSRL--------------------------------------------VLTREQLDNMPVLDSIIKEAMRLSSASLNVRMAKSDFLLQLDNKESYHIR---KDDVIAMYPP-MIHFDPEIYDDPLEFKYD------RYIDENGQEKTTFYRNGRKLRYYYMPFGSGV-----------TKCPGR-FFAVHEIKQFLSLLLSYFEMELLDSDVKEPPLDQSRAGLGVLQPTY--------DVDFRYRLKSL----------------------------------------------------------------------- Danio_rerio_DrCYP7B1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLEYLLTILLGFIS------------------------VLLLYSFCGRRRKDGEPPLIKGWIPFLGKALEFRKN-----------------SQEFLTRLQ------KEHGDDFTVLIAGRYITFIMNPLQYPSVIKHGKQ-------LDFHTFSDSAASRTFDYPPIRSGHFPGLSDQIQRSYTLLQGPALDPLT---------FSMMGNLQKVLRQLFL-----------SGDEADDHWQQAELYKFCKSAMFQSTFKTLYGHS------------------------PHLDLDQLREDFEKFDDMFPLLMARIPIGLLGKTKEIREKLIHFFYPQ--------RMMEWTAPCEFVQTRTAL--------------------------------------------FQDYDTLQDRDKAAHHFAMLWASVGNTIPAAFWCLYHLISCPEALAAVREEITNVLGEKNMQLIFK-EDI--------------------------------------------AITRQQLEQMVYLESSVNESLRLYSVSMNIRVVQEDFCLRLDGQRSINMR---KDDIIALYPQ-STHLDPEIYKEPKRFQFD------RFVKD-GKEKTDFYKSGQKVRYYRMPFGSGA-----------TQCPGR-FFAMNELKQFVCVTLLMCEMQLLDGQQE-ASMDNSRAGLGILPPAN--------PIPFKYKTRKTLDCTDREE--------------------------------------------------------------- Danio_rerio_DrCYP7D1 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLCNLQTVLER--------------CLPHE-HDWLEEGLQSFTNRIMFEAGFLTLFGKEDIGF--------LQDH----GMSGNRISMPKATQDFLVFDHAFPLLAAGVPIGLCTKAWRAREALAEELLHD--------ELHRRKCISDLIQRRMDI--------------------------------------------FDRM-LLDETGKARTHVCMLWASQANTLPAAFWSLYYTLKSVDAFTAARTEVNRVL--LGQSLNNKDQTV--------------------------------------------YLSKDQLDSMTVLESIIEEALRLSSASMMIRVASDDFTLTLESDQTAAIR---KGDYIALYPQ-LLHLDPEIYPNPTEFKYN------RFLDENDQPKTNFFKSGRRLRNFLMPFGSGA-----------SECPGR-FFAVYEIKLFLALTLWHYDLQLRDPDVP-VVQDSARAGLGIMPPSQ--------DVLLRFRKKQRTPGNEHKDTK------------------------------------------------------------- Danio_rerio_DrCYP8A1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMWTALLLVGLSILVIVLYGRR----------------------------TRRRNEPPLDKGMIPWLGHALEFGKD-----------------AAKFLTRMK------EKHGDIFTVRAAGLYITVLLDSNCYDAVLSDVAS-------LDQTSYAQVLMKRIFNMILPSHNPES----EKKRAEMHFQGASLTQLS---------NSMQNNLRLLMTPS-------------EMGLKTSEWKKDGLFNLCYSLLFKTGYLTVFGAENNNS----------------------AALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKLWKWLTP--------SGLDRKPREQSWLGSYVK--------------------------------------------QLQDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQGGKHLRLEERQK---------------------------------------------------------NTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNGQEYHLR---RGDRLCVFPFISPQMDPQIHQQPEMFQFD------RFLNADRTEKKDFFKNGARVKYPSVPWGTED-----------NLCPGR-HFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAG--------DLEIRYRIRF------------------------------------------------------------------------ Danio_rerio_DrCYP8B1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALVQILLALLISVIGALYLLG-------------------------SFRRRRTGEPPLEKGPIPWLGHVLEFRKD-----------------TAKFLNRMK------AKHGDIFTVQLGGFYFTFITDPLSFGAVVKEARAK------LDFTKFAEQLVQRVFGYHSIQSEHKV----LQASSTKHLMGDGLVVMT---------QAMMYNLQNLMLHS-------------VGSGNGKVWQESGLFAYSYNIVFRAGYLSLFGNESPKG--------TGKESVEKAKEIDRQESNDLFWEFRKYDQLFPNLAYGVLGPSEKMEAERLKRLFWSTLSV--------QKMRARDNISGWVSDQQQ--------------------------------------------VRAEHGMQEFMQDRYMFLLLWASQGNTGPSAFWLLLYLMKHPEAMSAVRKEVEEILKEAGQEVKPGGPLI--------------------------------------------DLSRDMLLKTPILDSAVEETLRLTAAPILTRAVMQDMTIIMANGQEYKIR---EGDRVAVFPY-VVHVDPEVHPDPLTFKYD------RFLNADGSRKTDFYKGGKKLKYYSMPWGAGT-----------TMCPGR-FFATNELKQFVFLMLSYFDFELTNPNEQIPGIDIRRWGFGSMQSDR--------DIQFRYRPRI------------------------------------------------------------------------ Danio_rerio_DrCYP8B2 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKRKETYECQKMESLVQILLALLLSVIGALYLLG-------------------------GFRRRRTGEPPLEKGLIPWLGCVLEFRKD-----------------TVKFLQRMK------AKHGDIFTVQLGGFYFTFITDPQSFGAVVKESRAK------LDFTNFADQLVERVFGYGAVEIKHKFFKN-LQTTSTKHLMGDGLVVMT---------QAMMYNLQNLMLHS-------------VGSGNGKVWQESGLFAYSYNIVFRAGYLSLFGNESPKG--------TGKESVEKAKEIDLQHSNDLFWEFRKYDQLFPNLAYGVLGPRGKMEAERLKRLFWNMLSV--------QKMKARDNVSGWVSDQQQ--------------------------------------------VRAEHGMQEFMQDRFMFLLLWASQGNTGPSAFWLLLYLMKHPEAMSAVRKEVEEILKEAGQEVKPGGPLI--------------------------------------------DLSRDMLLKTPILDSAVEETLRLTTAPLLTRGVMEDMTIIMANGQEYKIR---EGDRVSVFPY-LVHIDPEVHPDPLTFKYD------RFLNADGSRKTDFYKDGKKLKYYSMPWGAGT-----------TMCPGR-FFATNELKQFVFLMLSYFDLELKNPNEEIPSIETRRWGFGSMHPDR--------DIQFRYRPRI------------------------------------------------------------------------ Danio_rerio_DrCYP8B3 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKRKETYECQKMESLVQILLALLLSVIGALYLLG-------------------------GFRRRRTGEPPLEKGLIPWLGCVLEFRKD-----------------TVKFLQKMK------AKHGDIFTVQLGGFYFTFITDPLSFGAVVKESRAK------LDFTKFSDQLVERVFGYHPMENEHKF----LQTASTKHLMGDGLVVMT---------QAMMYNLQNLMLHS-------------VGSGNGKVWQESGLFAYCYNIVFRAGYLSLFGNESPKG--------TGKESVEKAKEIDLQHSNDLFCEFRKYDQLFPNLAYGVLGPRGKMEAERLKRLFWSTLSV--------QKMRVKDNISGWISDQQQ--------------------------------------------VRAELDMQEFMQDRFMFLLLWASQGNTGPSAFWLLLYLMKHPEAMSAVRKEVEEILKEAGQEVKPGGPLI--------------------------------------------DLSRDMLLKTPILDSAVEETLRLTTVPLLTRGVVQDMTIIMANGQEYKIR---EGDRVSVFPY-LVHIDPEVHPDPLTFKYD------RFLNADGSRKTDFYKDGKKLKYYSMPWGAGT-----------TMCPGR-FFATNELKQFVFLMLSYFDFELTNPNEQIPDIDIRRWGFGSMHPDR--------DIQFRYRPRI------------------------------------------------------------------------ Danio_rerio_DrCYP11A1 -----------------------------------------------------------------------------------MARWNVTFARLDQS---------------------------------------------------------------------------------------LSSLKN------------LLQVKVTR-SGRAPQNSTVQPFN-----------------------------KIPGRW-RNSLLSVLAFTK----------------MGGLRNVHRIMVHN--FKTFGPIYREKVGIYDSVYIIKPEDGAILFKAEG---HHPNRINVDAWTAYRDYRNQKY-GVLLKEGKAWKTDRMILNKELLLPKLQGTFVP-----LLEEVGQDFVARVNKQIERSGQK----------QWTTDLTHDLFKFSLESVSAVLYGERLGLLLDNI----DPEFQHFIDCVSVMFKT--TSPMLYLPPGLLRSIGSNIWKNHVEAWDGIFNQADRYIQNIFKQW-------KENPEGNG-----KYPGVLA------------------------------------------ILLMQDKLSIEDIKASVTELMAGGVDSVTFTLLWTLYELARQPDLQDELRAEISAARIAFKG------------------------------------------------------DMVQMVKMIPLLKAALKETL-RLHPVAMSLPRFIT-EDTVIQNYHIPA------GTLVQLGVYAMGRDHQFFPKPEQYCPS------RWISSKRQ------------YFKSLGFGFG-----------PRQCLGR-RIAETEMQIFLIHMLENFRIEK-QKQIEVRSKFE-----LLLMPEK--------PIMLTIKPLNASR--------------------------------------------------------------------- Danio_rerio_DrCYP11C1 MESVVKRSLLAPMKTLQCCVSGDKQQASRSQGQRSKVTRVQDPRVLRSYEAELQKERKLREAMNAKKNAERAAMRAHFRRKYQLSQNAKDSAQLRAVGGKVFLSGDLARMVRPDAPEKDDGFNLIRAFQGLKFSGPMFTGSKHSRADKTTNEEPCRVIRRTDAQDTLLFSSSQCSVCEISIGSMFSSCAGSVCARP--HLCVRASVCVRPLHQSSRSAGAARLFQ-----------------------------EIPDTG-SNGWMNLLRFWR----------------DGRFSRMHKHMEES--FRRLGPIYREHLGSQSSVNIMLPMDTGELFRSEG---LHPRRMTLQPWATHRETRRHSK-GVFLKNGTEWRADRLLLNREVMVSSSVHRFLP-----LLDEVAQDFCRSLRRRVQADGFE-KAG----QHTLTLDPSPDLFRFALEASCHVLYGERIGLFSSCP----SDESERFISAVERMLAT--TPPLLYLPPRLLLRLRASLWTTHATAWDDIFSHAEQRIQRSYQRL-------QARPSAAP---DCSFPGVLG------------------------------------------KLMEAGQLSLELIRANITELMAGGVDTTAVPLQFALFELARNPDVQECVRAQVLSSWQQASG------------------------------------------------------DPLKALQGAPLLKGTIKETL-RLYPVGITVQRYPV-RDIVLQNYHVPA------GTLVQVCLYPLGRSAEVFSRPECFDPS------RWSADADAGSA-----G---GFRSLAFGFG-----------SRQCVGR-RIAENEMQLLLMHILRTFKLTV-SSTEELSTKYT-----LILQPEC--------PPRITFSTLTHQH--------------------------------------------------------------------- Danio_rerio_DrCYP17A1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTMAEALILPWLLCLSLFSAVTLAALYLKQKMNGFV-------------------------PAGNRSPPSLPSLPIIGSLMSLVSD---------------SPPHIFFQDLQ------KKYGDLYSLMMGSHKLLIVNNHHHAKEILIKKG---KIFAGRPRTVTTDLLTRDGKD--IAFADYSSTWKFHRKMVHGALCMFGEGSVS-------IEKIICREASSMCEVLTES-----------QNS--AVDLGPELTRAVTNVVCALCFNSSYKRGDAEF----ESMLQYSQG-IVDTVAK----DSLVDIFPWLQIFPNKDLRILRQCISIRDKLLQKKYEEHKVTY-------SDNVQRDLLDALLRAKRSSENN------------------------------------NS---STRDVGLTEDHVLMTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERH------------------------------------------------------PQLSDRGNLPYLEATIREVL-RIRPVSPLLIPHVALQDSSVGEYTVQK------GTRVVINLWSLHHDEKEWKNPELFDPG------RFLNEEGD-G------LCCPSGSYLPFGAG-----------VRVCLGE-ALAKMELFLFLAWILQRFTLEMPTG-QPLPDLQG-KFG--VVLQPK--------KFKVVAKVRADWEKSPLMQHC------------------------------------------------------------- Danio_rerio_DrCYP17A2 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MCSVSVCVCFSALLLLLLLLVRRLLEG-------------------------VGSSSVSFPCLPRLPLLGSLLHLRSN---------------LPPHLLFTQLS------SQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRG---REFAGRPKMVTTDLLTQGGKD--IAFADYSPLWKNHRRLVHSSFTLFGEGSNK-------LQTIVQEAADSLCEELQAC-----------RGQS--SDLSVVLMRAVTNVICRLVFSSSYQPSDPEL----QTVIQYNDG-IVQTIAR----GGLVDIFPWLRIFPNKDLKRLKECVSIRDQLLYKKLLEHKKSL-------TPGEPRDLLDALLIGQQR------------------------------------------GSGGADD--ITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRP------------------------------------------------------PCLSDRPHLPLLDAVLCEVM-RIRPVSPILIPHVAMQDTSLGGHSVPK------GTRVLVNMWAIHHDPKHWDQPEQFNPE------RFLEPSGK---------KKTQSSFLPFGAG-----------PRVCVGE-SLARIELFLFVSRPLQRFSFSCPSE-ASLPDLQG-RFG--VVLQPE--------RYTVTVTPRH------------------------------------------------------------------------ Danio_rerio_DrCYP19A1A ------------------------------------------------------------------------------------------------------------------------------------------------------------------MAGDLLQPCGMKPVRLG-EAVVDLLIQRAHNGTERAQDNACGATATILLLLLCLLLAIRHHRP----------------------------HKSHIPGPSFFFGLGPVVSYCR-----------FIWSGIG-TASNYY-----NSKYGDIVRVWINGEETLILSRSSAVYHVLRKSL------YTSRFGSKLGLQCIGMHEQGIIFNSNVALWKKVRAFYAKALTGPGLQRTME------ICTTSTNSHLDDLSQLTDA--------------QGQLDILNLLRCIVVDVSNRLFLGVPLN----------EHDLLQKIHKYFDTWQTVLIKPDVYFRLDWLHKKHKRDAQELQDAITALIEQKKVQLAHAEKLD-----------HLDFTAELIFAQSHGELS-------------------------------------------------AENVRQCVLEMVIAAPDTLSISLFFMLLLLKQNPDVELKILQEMD--SVLAGQ-----------------------------------------------------SLQHSHLSKLQILESFINESL-RFHPVVDFTMRRALDDDVIE-GYNVKK------GTNIILNVGRMHR-SEFFSKPNQFSLD----------NFH---------KNVPSRFFQPFGSGP-----------RSCVGK-HIAMVMMKSILVALLSRFSVCPMKACTVEN----IPQTNNLSQQPVE----EPSSLSVQLILRNTL---------------------------------------------------------------------- Danio_rerio_DrCYP19A1B -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMEHVVKDAVNIGAVVQGTLLLLTGTLMLILLHRIFGVKNWR------------------------------NQSALPGPGWWLGLGPVLSYSR-----------FLWMGIG-TACNYY-----NEKYGSIARVWINGEETVILSKSSAVYHVLKSNN------YTGRFASAKGLQCIGMFEQGIIFNSNIAKWKKVRTYFTKALTGPGLQKSVE------VCVSATNRQLDVLQEFTDA--------------SGHVDVLNLLRCIVVDVSNRLFLRIPLN----------EKELLIKIHRYFSTWQTVLIQPDIFFKLDFVYRKYHLAAKELQDEMGKLVEQKRQAINNTEKLD-----------EMDFATELIFAQNHDELS-------------------------------------------------VDDVRQCVLEMVIAAPDTLSISLFFMLLLLKQNSAVEEQIVQEIQ--SQIGSR-----------------------------------------------------DVESADLQKLNVLERFIKESL-RYHPVVDFIMRQSLEDDYID-GYRVAK------GTNLILNIGRMHK-TEFFKKPNEFSLE----------NFE---------NTVPSRYFQPFGCGP-----------RACVGK-HIAMVMTKAILVTMLSRFTVCPRHGCTIST----IRQTNNLSMQPVE---EDPDCLAMRFIPRAQNSNGETADNRTSKE--------------------------------------------------------- Danio_rerio_DrCYP20A1 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLDFAIFAVTFVIILIGAVLYLYPSSRRASG-----------------------------VPGLNPTEEKDGNLQDIVNK---------------GSLHEFLVGLH------DEFGSVASFWFGARPVVSLGAVNQLRQHINPNW------TTDSFETMLKSLLGYQSG-----SGVGLTESMMRKKVYEGAINKTLENNFP------LLLQQVEELVDKWASYP---------------KSQHMPLCAHLLGLAMKAVTQLAMGSRFRDDAEVIR------FRKNHEAIWSEIG--------KGYLDGSLEKSSSRKAHYESALAEMESVLKSVAKQRPGQG---------SSQSSFVNYLLQANLTER-----------------------------------------------------QVMEDGMVFTLAGCVITANLCIWAVHFLSVSEAVQDRLYHELVEVLGDEPV-------------------------------------------------------SLEKIPQLRYCQQVLNETV-RTAKLTPVAARLQEVEGKVD-QHVIPK------ETLVIYALGVVLQDADTWSLPYRFNPD------RFAEESVM-----------KSFSLLGFSGS------------QACPEL-RFAYTVATVLLSTLVRRLRMHRVDGQVVEARYE-------LVTTPK-------DDTWITVSKRN------------------------------------------------------------------------ Danio_rerio_DrCYP21A1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MCFSVVSVVLLLFILWMLVVKFRRQSHRRTDGVAKENNKPEGRR----LLHSLYKLFFSTVSPTISGPRSLPLLGNMLDLAQD---------------HLP-IHLTALA------KCYGNIYRLNCGSTTMVVLNNSEIIREALVKKW---SDFAGRPHSYTGDIVSRGGRT--ISLGDFSEEWKAHRRVTHSALQRCTTDS---------LHSVIEKQAQHLCQVLRDY-----------SGKA--VDLSEDFTVASSNVITTLTFSKAYDKSSAEL----QKLQECLNE-IVSLWGS--PWISALDSFPLLRKFPNPPFSRLMKEVARRDELIGKHIEEFKKSE-------HKEG-GTLTSSLLKCLEPQ-----------------------------------------QGAAN-HTTLTDTHVHMTTVDLLIGGTETIAALLNWTVAFLLHRPEVQDKVYEELCCMLD-VRH------------------------------------------------------PQYSDRHKLPYLCALISEML-RLRPVAPLAVPHRAIRNSSIAGHFIPK------NTIIIPNLYGAHHDPEVWDDPYSFKPE------RFLEGGGG-----------SLRSLIPFGGG-----------ARLCLGE-AVAKMEMFLFTAYLLREFKFLPASKEEPLPELRG-VAS--VVLKVK--------PYTVIAHPRE------------------------------------------------------------------------ Danio_rerio_DrCYP24A1 ---------------------------------------------------------------------------MFYTRLKMRAHLQRAPQILELLKK---------------------------------------------------------------------------------------KTVGLQHCKPTSSVCVLDSKDAAGSAPC------AHSLD-----------------------------SIPGPTNWPLFGSLIEVIR----------------NGGLKRQHETLIHF--HKKFGKIFRMKLGSFESVHIGSPCLLEALYRKEG---SYPERLEIKPWKAYRDMRDEAY-GLLILEGRDWQRVRSAFQQKLMKPTEVMKLDG-----KINEVAADLIKRIGKVN--GKMDA--------------LYFELNKWSFETICYVIYDKRFGLLQDSV----SKEGMDFITAVKTMMST--FGTMMVTPVELHKTLNTKTWKDHTEAWDRIFSTAKHYIDKNLQKQ-------SNG----------EADDFLS------------------------------------------DIFHNGNLTKKELYAATTELQVGGVETTANSMLWVIFNLSRNPCAQGKLLKEIQDVVPAGQT------------------------------------------------------PRAEHIKSMPYLKACLKESM-RVSPSVPFTSRTLD-KDTVLGDYTLPK------GTVLMLNSQAIGVSEEYFDNGRQFRPE------RWLEE-----K-----SSINPFAHVPFGVG-----------KRMCIGR-RLAELQIQLGLCWILRDYKIVATDLEP-VDSLHS-----GTLVPSR--------ELPVAFVPR------------------------------------------------------------------------- Danio_rerio_DrCYP26A1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGLYTLMVTFLCTIVLPVLLFLAAVKLWEMLMIRRVDPNC-------------------------RSPLPPGTMGLPFIGETLQLILQ------------------RRKFLRMK-----RQKYGCIYKTHLFGNPTVRVMGADNVRQILLGEH--------KLVSVQWPASVRTILGSDTLSNVHGVQHKNKKKAIMRAFSRDALEHYIP-----VIQQEVKSAIQEWLQKDS------------------CVLVYPEMKKLMFRIAMRILLGFEPEQIKTDE----QELVEAFEEMIKNLFS-------------LPIDVPFSGLYRGLRARNFIHSKIEENIRKKIQDDD-------NENEQKYKDALQLLIENSR--------------------------------------------RSDEPFSLQAMKEAATELLFGGHETTASTATSLVMFLGLNTEVVQKVREEVQEK--VEMG-----------------------------------------------MYTPGKGLSMELLDQLKYTGCVIKETL-RINPPVP-GGFRVALKTFELNGYQIPK------GWNVIYSICDTHDVADVFPNKDEFQPE------RFMSKGLED---------GSRFNYIPFGGGS-----------RMCVGK-EFAKVLLKIFLVELTQHCNWILSNGP-PTMKTGP-------TVYPVD-------NLPTKFTSYVRN---------------------------------------------------------------------- Danio_rerio_DrCYP26B1 ----------------------------------------------------------------------------------------------------------------------------------------------MSQRVISNRVGHSPNFRFNHFIAHHSKEIFETSPRTFTAMLFESFDLVSALATLAACLVSMALLLAVSQQLWQLRWTATRDKSC-------------------------KLPMPKGSMGFPIIGETCHWFFQ------------------GAGFHASR-----RQKYGNVFKTHLLGRPLIRVTGAENVRKVLMGEH--------SLVTVDWPQSTSTLLGPNSLANSIGDIHRKRRKIFAKVFSHEALESYLP-----KIQQVIQETLRVWSSNPD------------------PINVYRESQRLSFNMAVRVLLGFRIPEEEMH------CLFSTFQEFVENVFS-------------LPIDLPFSGYRKGIRARDSLQKSIEKAIREKPLH---------TQ-GKDYTDALDVLLESAK--------------------------------------------ENNTELTMQELKESTIELIFAAFATTASASTSLVMQLLRHPAVLEKLREELRSCGLLHDG-----------------------------------------------CLC-QGELRLDSIISLKYLDCVIKEVL-RLFAPVS-GGYRIATQTFELDGVQVPK------GWSVMYSIRDTHDTSAVFKDVEAFDPD------RFSPERSEDR--------EGRFHYLPFGGGV-----------RSCLGK-QLATLFLKLLAVELAGGSRFELSTRTFPRMISVP-------VVHPTD-------GLRVKFFGLDSNQNQIMAKSDEMLDATV------------------------------------------------------ Danio_rerio_DrCYP26C1 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFGHDFCLVSALLSVADAVLPTVLLLAVSRLLWEFRWSITRDRTC-------------------------KLPLPQGSMGWPLVGETFHWLFQ------------------GSSFHISR-----REKHGKVFKTHLLGKPLIRVTGAENIRKILLGEH--------TVVCTQWPQSTRIILGPNTLVNSVGDLHKRKRKVLAKVFSRGALEAYLT-----RLQDVVKSEIAKWCTETG------------------SVEVYTAAKSLTFRIAVRVLLGLHLEEQQIT------YLSKTFEQLMNNLFS-------------LPIDTPVSGLRKGIRAREILHSAMEKIIEEKLKK---------QQ-ASDYCDAFDYMLSSAR--------------------------------------------ENDYELTMQELKETAVELIFAAHSTTASASTSLIMQLLRHPDVSERARAELESEGLITDGHGHCRSRCNGNAISEEGEAAEKSTSDRRSAINKATYFEAGDKEEGRRSRTHVPYLSLEKLSQLSYLDCVVKEVL-RFLPPVS-GGYRTVLQTFELNGYQIPK------GWSVMYSIRDTHETAEAYQNPELFDPD------RFCVGREESK--------SERFSYVPFGGGV-----------RRCIGR-ELALIVLKTLAVELLATADCTLATQTYPRMQTVP-------IVHPVN-------GLHVFFNYRTQGIERNRRESTHI----------------------------------------------------------- Danio_rerio_DrCYP27A1.4 -----------------------------------------------------------------------------------MAVSFALSSAERL------------------------------------------------------------------------------------------GWCFLRPTTAATGFRRAAGNSAAASVSVQDGHRKLKTEA-----------------------------DLPEI---KIFTMLYQMLF----------------KGYLNSVHELQLYQ--KQVYGPLWKINAGNLQGISITSVELLEELLRKDE---KYPCRGYMTLWTEHRDLRGISY-GPFTEEGEKWYKLRAVLNKRMLHPKDSLQYGD-----VVNAVITDFIKRIYYLREMSPTGD----------LVSNLTNELYRFSLEGIASILFETRIGCLEKEI----PAETQEFINSIAQMFT---YNMHVALLPNWTRNYLP-FWQKYIDGWDGIFKFGTKMINLKMEAI-------QTRLDTNQ----EVAGEYLT------------------------------------------YLLSSGKMSCKDVYGSVSEVLLAGVDTTSNTMLWALYLLSKDPAAQETLHQEVTKVLKGDRI------------------------------------------------------PTAEEVNSMPFLKAVIKETL-RLYPVVPVNSRLIAESEVIIGEYLFPK------KTTFNLFHYAISHDEKVFPEPQKFKPE------RWLRD--GRTR-----PN--PFGSIPFGFG-----------VRACVGR-RIAELEMHLALARLIKLFEMRPDPTVGEVKANFR-----SVLVPNK--------KVNLHFVERQKTET-------------------------------------------------------------------- Danio_rerio_DrCYP27A3 ---------------------------------------------------------------------------------------MFSNSLLRT------------------------------------------------------------------------------------------GLFLCKQDCSGIKCLTSMFLNARTTSTLIGG-DKQKTMD-----------------------------DLDGP---SFLTSLYWLFG----------------KGYFQTTHQMQIEH--SKIYGPLWKSKYGPLVIVNVASADLIEQVLRQEG---RHPIRTDMPHWRGYRKLRNHAY-GPLTEMGPEWQRIRSILNPRMLKPKHVSNYTN-----AINGVVSDFIEKMAKLKTTKGNDV----------MVYDVAGELYKFAFEGISSVLFETRMGCLNDEI----PEETQKFIFSVGEMFR---LSPIVILFPKFLWPYMP-FWKHFVAVWDHLFKVADELVQQKMTEI-------QEKVKTGS----PVEGEYLT------------------------------------------HLLISEQMSFTEVLGSITELLLAGVDTTSNTISWALYHLAREPEIQQKLHEEVVSVCPGDKT------------------------------------------------------PSSDDITRMPLLKAIVRETL-RLYPVVPGNARVVAENEIVVGDHLFPK------NTLFHLCHFAVSYDETVFPDPFAFLPQ------RWIRE-QKQLS-----QH--PFGSVPFGFG-----------IRACLGR-RVAELEMYLLLSRLIKRYEVRPDPSGKTVKPITR-----TLLVPAT--------SIDLQFIDR------------------------------------------------------------------------- Danio_rerio_DrCYP27A5 -----------------------------------------------------------------------------------MAVCFALSSAERL------------------------------------------------------------------------------------------GLGFLRPMAAATGFRSAAGNAAAASVSVQDGHRKLKTEA-----------------------------DLPEI---KIFTMLYQMLF----------------KGYLNS------------------------------------------------------------------------------------------MLHPKDSVQYGD-----VVNAVITDFIKRIYYLREMSPTGD----------LVSNLTNELYRFSLEGIASILFETRIGCLEKEI----PVETQEFINSIAQMFT---YSMHVALLPNWTRNYFP-FWQKYIDGWDGIFKFGTKMIDMKMEAI-------QKRVDTNQ----EVAGEYLT------------------------------------------YLLSSGKMTSKDVYGSVSELLLAGVDTTSNTMLWALYLLSKDPAAQETLYQEVTKVLKDDRI------------------------------------------------------PTAEEVNSMPFLKAVIKETL-RLYPVVPVNSRLIAETEVVIGEYFFPK------KTTFNLCHYAISHDEKVFPEPQKFKPE------RWLRD--GRTR-----PN--PFGSIPFGFG-----------VRACVGR-RIAELEMHLALARLIKLFEMRPDPTVGEVKANFR-----SVLVPNK--------KVNLHFVERQKTET-------------------------------------------------------------------- Danio_rerio_DrCYP27A6 -----------------------------------------------------------------------------------MAVCFALSSAERL------------------------------------------------------------------------------------------GWCFLRPTAAATGFRSAAGNAAAASVSVQDGHRKLKTEA-----------------------------DLPEI---KIFTMLYQMLF----------------KGYLNS------------------------------------------------------------------------------------------MLHPKDSVQYGD-----VVNAVITDFIKRIYYLREMSPTGD----------LVSNLTNELYRFSLEGIASILFETRIGCLEKEI----PAETQKFINFIAQMFT---YSMHVALLPNWTRKYFP-FWQKYIDGWDGIFKFGTKMIDMKMEAI-------QKRVDTNQ----DVAGEYLT------------------------------------------YLLSNGKISRKDVYGSVSELLLAGVDSTSNTMLWALYLLSKDPEAQETLYQEVTKVLKDDRI------------------------------------------------------PTAEEVNSMPFLKAVIKETL-RLYPVVPVNSRLIAETEVVIGEYFFPK------KTTFTLCHYVISRDEKVFPEPQKFKPE------RWLRD--GRTR-----PN--PFGSIPFGFG-----------VRACVGR-RIAELEMHLALARLIKLFEMRPDPTVGEVKANFR-----SVLVPNK--------KVNLHFVERQKTET-------------------------------------------------------------------- Danio_rerio_DrCYP27A7 -----------------------------------------------------------------------------------MAVCFALSSAERLGI----------------------------------------------------------------------------------------GLGFLRPTAAATGFRRAAGNAAAASVSVQDGHRKLKTEA-----------------------------DLPEI---KIFTMLYRLLF----------------KGYLSRMHELQLYE--KQLYGPLYKINVGNFQSVALNSVDLLEELLRKDE---KFPSRGDMTLWTEYRDMKGIGY-GPFTEEGEKWYKLRAVLNKRMLHPKDSVQYGD-----VVNAVITDFIKRIYYLREMSPTGD----------LVSNLTNELYRFSLEGISSILFETRIGCLEKEI----PAETQHFINSIAQMLT---YSMPVVFMPNWTRNYLP-FWQRYIGGWDGIFKFAGKMIDMKMEAL-------QKRVDANQ----EVAGEYLT------------------------------------------YLLSNGKMSSKDVYGSVSELLLAGVDTTSNTMLFALYHLSKDPETQDILYQEVTNVLKDDRI------------------------------------------------------PTAQEVNTMSYLKAVIKETL-RLYPVVPMNARLIAENEVVIGGHLFPK------NTTFTLCHYAISRDEKVFPEPQKFKPE------RWLRD--GRTR-----PN--PFGSIPFGFG-----------VRGCVGR-RIAELEMYLALARLIKLFEIRPDPTVGEVRSLNR-----TVLAPDR--------KVNLHFVERKKTEA-------------------------------------------------------------------- Danio_rerio_DrCYP27B1 -------------------------------------------------------------------------------------MMMVLHQALKVT---------------------------------------------------------------------------------------------GRSALPLLRFAERWADVIRAPPTP-----QVKTLE-----------------------------QMPGP---SPARFIRDLFM----------------KRGFSRLHQLQLEG--RQKYGPMWKASFGPILTVHVAEPELIQQVLRQEG---QHPVRSELSSWKDYRALRGEGY-GLLTAEGEEWQCVRSLLSKHMLRPQAVEAYDG-----ALNAVVSDLLQKLKLRSQESSSR-----------IVSDISAEFYRFGLEGISSVLFESRIGCLDAVV----PVETERFIQSINTMFV---MTLLTMAMPQWLHRLLPKPWDTFCRCWDVMFEFAKGHIDQRLQEE-------KQKLECGE----QLEGRYLT------------------------------------------YFLSQAGLPLTSVYSNVTELLLAGVDTISSTLSWSLYELSRHPDVQTALRDEVLSVMKDRSV------------------------------------------------------PQASDVAAMPLLKAVVKEIL-RLYPVIPANARVIN-KDIEVGGYVIPK------NTLITLCHYATSRDPQQFRDPDSFRPQ------RWGDR---SDR-----SH--PYATVPFGVG-----------KRSCIGR-RIAELEVYLALSRILMHFTMEPVRENDTVHPMTR-----TLLVPER--------QIDLRFTER------------------------------------------------------------------------- Danio_rerio_DrCYP27C1 ---------------------------------------MRTPSHLQAAPQFSLVSIYAVFDMALQSTILHMARKNLLQES-CRQLLIQTHGLHKSVA----------------------------------------------------------------------------------------SGSLEIAAHSQADLKEESAVSPAEE---VQKAARVKSLK-----------------------------EMPGP---STVANLLEFFY----------------RDGFSRIHEIQMEH--AKKYGKIFKSRFGPQFVVSIADRDMVAQVLRSES---ATPQRGNMESWKEYRDLRGRST-GLISAEGDEWLKMRSVLRQLIMRPRDVAVFSS-----DVNDVVADLVKRVKTLRSQQDDSQ----------TVLNINDLFFKYAMEGVATILYETRLGCLENEI----PKMSQEYITALHLMFSSFKTTMYAGAIPKWLRPIIPKPWEEFCSSWDGLFKFSQIHVDKRLSEI-------KKQMEKSE----EIKGGLLT------------------------------------------HMLVTREMNLEEIYANMTEMLLAGVDTTSFTLSWSTYLLARHPTIQQQIFEEVDRVLG-GRV------------------------------------------------------PTGEDVPYLPLIRGLVKETL-RLFPVLPGNGRVTH-DDLIVGGYLIPK------GTQLALCHYSTSMDEENFPRPEEFRPD------RWIRK-DASDR-----VD--NFGSIPFGYG-----------IRSCIGR-RIAELEMHLALTQLLQNFHIEVSPQTTEVHAKTH-----GLLCPGA--------SINLRFTDRK------------------------------------------------------------------------ Danio_rerio_DrCYP39A1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEWITLILTVSVVIISFHLLFGKSHPNAP-----------------------------PCIRGWIPWFGAAFEFGKAP-----------------LHFIQQAR------AKYGPVFTVVAAGKRMTFVTLNEDFRVFFTSKD--------VDFEQAVQEPVHNTAS-----ISKDNFFESHPTCSAIIKGRLTPGNTAM------LSPHLCEEFNDHLESLG-------------------SEGSGQLNELIKSVMYPSVMSNLLGRCNSPS-----SALSRQEFLEKFTTYD--------EGFEYGSQLPEMFLKEWSNSKHWLLSLLRKMVIKSEETL-----------YSESDRKTLLQHLAAS-------------------------------------------------ISEQYLPNYGLLLLWASLANAIPVTFWAVAFILSNPTAYKIVMDQINSVLGRQDKQK--------------------------------------------------TKVTLDDLQQMPYVKWCIMEAI---RLRAPGAITRKVVRPLKLQNYVIPP------GDMLMLSPYWAHRNPKYFPDPEDFKPE------RWETADLE--------KNVLLEGFVAFGGGK-----------NQCPGR-WYAIMELHMFVALILYKFEFAQLDPMPKPSP-----LHLVGTQQPDG-------PCTVRYKHR------------------------------------------------------------------------- Danio_rerio_DrCYP46A1.1 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MISEWVLYIVFFLLAAVFTAFLGYCLYIHHLHQKYD----------------------------HIPGPPRDSFLLGHSSSLTKAV-----------YSDNNLIHDLFLHW-----AEKYGPVYRINTLHYVTIMVYCPEATKTIMMSPK---YIKDPFVYKQLFNLFGKRFLGNGLITAVDHDMWYRQRRIMDPAFSSTYLRSLIS------TFDEMSERLMDKLEEMANN--------------KTPAVMHDLVNCVTLDVICKVAFGVDLNLLNQKD-SPFQNAVELCLKGMILDVRDPFFRLFPKNW--KLIQQVREATELLRKTGEKWIQNRKTAVKNGED------------VPKDILTQILKSAEEENVN---------------------------------------------NTQDLEQMLDNFVTFFIAGQETTANQLSFAIMALGRNPEIYKRAKAEVDEVLGTKR------------------------------------------------------EISNEDLGKLTYLSQVLKETL-RLYPTAPGTNRWLHEDIVIN-GIKVPR------GCSVMFSSYVSQRLEKFFKDPLKFDPE------RFDVN-----------APKPYYCYYPFSLGP-----------RTCLGQ-VFAQMEAKLVLAKLLQRFEFSLVPGQS-------FDIKDNGTLRPK-------SGVICNIKQCS------------------------------------------------------------------------ Danio_rerio_DrCYP46A1.2 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVSEWILYIIFYLLSAVFTAFLAYCLYIHHLHQKYD----------------------------HIPGPPRDNFLLGHSPSLTKAM-----------YSDDSLIHDLFLQW-----AEQYGPVYRINTLHYIAIVVHCPEATKTILMSPK---YAKDPFSYSRLFNLFGKRFLGNGLVTAVDHDIWYRQRRIMDPAFSSSYLRSLIS------TFDEMSERLMDKLEEMANN--------------KTPAVMHDLVNCVTLDVICKVAFGVDLNFLTQKD-SPFQNAIELCLNGMALDARDPLFRIFPKNW--KLIQQIRDAAVLLRKTGEKWIQNRKTAVKNGED------------VPKDILTQILKIAEEENVN---------------------------------------------SSEDLEQMMDNFVTFFIAGQETTANQLSFAIMALGRNPEIYKRAKAEVDEVLGTKR------------------------------------------------------EISNEDLGKLTYLSQVLKETL-RLYPTAPGTNRWLHEDMIIN-GIKIPG------GCSVMFSSFVSQRLEKFFKDPLKFDPE------RFDEN-----------APKPYYCYYPFALGP-----------RTCLGQ-VFSQMEAKVVLAKLLQRFEFSLVPGQS-------FDIKDTGTLRPK-------SGVICNIKQCS------------------------------------------------------------------------ Danio_rerio_DrCYP46A1.3 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTSEWLLYMVFYLLSAVFVVFLAYCLYIHQVHQKYD----------------------------HIPGPPRDNFLLGHIPTINRVT-----------KSE-RHMNDLLLIW-----AEKYGPVYRLNSFHYVIINVHCPEATKTIMMSPK---YLKDPFIYKRLFGLFGKRFLGYGLVTATDHDIWYRQRRIMDPAFSSSYLRGLIS------TFNEMSERLMDKLEEMAIN--------------KTPAVMHDLVNCVTLDIICKVAFGVDLNLFKQTD-NPFQQAIEQCLQGMVLDLRDPFCKFFPKNW--KAIQETKGATVLLRKTGEQWIQNRKTAVEIGED------------VPNDILTQILKTAKEEKVN---------------------------------------------NTKDHEQMLDNFVTFFIAGQETTANQLSFAIMELGRHPEIYKRAKAEVDEVLGTKR------------------------------------------------------DISYEDLGKFTYLSQVLKETL-RLYPTAPGTNRWLHEDMVIN-GIKIPG------GISVIFSSYVAQRLEKHFKDPLKFDPE------RFNVN-----------APKPYYCYYPFSLGP-----------RSCLGQ-VFSQATP--AEGALAQLLTQLLTLCSH-------FLIV---LYFSK-------SSGHASL---------------------------------------------------------------------------- Danio_rerio_DrCYP46A1.4 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-----------YADDSLIHDLFLQW-----AEKYGPVYRINSLHYIAIVVHCPEATKTILMSPK---YTKDPFVYRRLFNLFGKRFLGYGLITAVDHDIWYRQRRIMDPAFSSSYLRSLIS------TFDEMSERLMDKLEEMANN--------------KTPAVMHDLVNCVTLDVICKVAFGVDLNFLTQKD-SPFQNAVELCLNGMTVDLRDPFFRLFPKNW--KLIKQIRDAAELLRKTGEKWIQNRKTAVKNGED------------VPKDILTQILKSAEEENVN---------------------------------------------NTDDLEQMLDNFVTFFIAGQETTANQLSFAIMALGRNPEIYKRAKAEVDEVLGTKR------------------------------------------------------EISNEDLGKFTYLSQVLKETL-RLYPTAPGTNRWLHEDMIID-GIKIPG------GCSVMFSSYVSQRLEKFFKDPLKFDPE------RFDVN-----------APKPYYCYFPFALGP-----------RTCLGQ-VFSQMEAKVVLAKLLQRFEFSLVPGQS-------FDIKDTGTLRPK-------SGVICNIKQCS------------------------------------------------------------------------ Danio_rerio_DrCYP51 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTILEVGSQLIESAVLQMS--LTSVLLTASVFTLTLGYFSKLLFTQ-------------------------HSS-EHTKYPPHIPSSLPFLGQAVAFGRS-----------------PIEFLEKAY------EQYGPVVSFTMVGKTFTYLLGSDAAALMFNSKNED------LNAEDVYARLTTPVFGKGVAYDVPNPLFLEQKKMLKTGLNIAQFKQHV---------EIIEEETKDYFRRWG-------------------ESGERNLFDALSELIILTASRCLHGCEIRSL--------LDER--------VAQLYADLDGGFTHAAWLLPGWLPLPSFRRRDRAHLEIKKIFYNVIKK--------RREDTEKHDDILQTLIDAT-------------------------------------------YKDGRPLSDDEIAGMLIGLLLAGQHTSSTTSAWMGFFLARDRALQERCYSEQKSVCGEELPPLHYD-----------------------------------------------------QLKDLSLLDRCLKETLRLRPPIMTMMRMAKTP----QKVGEYTIP---PGHQVCVSPTVNHRLQ-DTWAERLDFDPD------RYLHDNPAAG---------EKFAYIPFGAGR-----------HRCIGE-NFAYVQIKTIWSTLLRMFDFELVD--GHFPPVNYT----TMIHTPH--------NPIIRYTRRNTQPQQ------------------------------------------------------------------- ; END; BEGIN TREES; Title Km_CYP; LINK Taxa = Taxa; TRANSLATE [0] 1 Kryptolebias_marmoratus_Km.CYP1A, [1] 2 Kryptolebias_marmoratus_Km.CYP1B1, [2] 3 Kryptolebias_marmoratus_Km.CYP1C1, [3] 4 Kryptolebias_marmoratus_Km.CYP1C2, [4] 5 Kryptolebias_marmoratus_Km.CYP1D1, [5] 6 Kryptolebias_marmoratus_Km.CYP2AD12, [6] 7 Kryptolebias_marmoratus_Km.CYP2AD12.iso, [7] 8 Kryptolebias_marmoratus_Km.CYP2K38, [8] 9 Kryptolebias_marmoratus_Km.CYP2K39, [9] 10 Kryptolebias_marmoratus_Km.CYP2K40, [10] 11 Kryptolebias_marmoratus_Km.CYP2K41, [11] 12 Kryptolebias_marmoratus_Km.CYP2K42, [12] 13 Kryptolebias_marmoratus_Km.CYP2K43, [13] 14 Kryptolebias_marmoratus_Km.CYP2K44, [14] 15 Kryptolebias_marmoratus_Km.CYP2K45, [15] 16 Kryptolebias_marmoratus_Km.CYP2K46, [16] 17 Kryptolebias_marmoratus_Km.CYP2K47, [17] 18 Kryptolebias_marmoratus_Km.CYP2K48, [18] 19 Kryptolebias_marmoratus_Km.CYP2K49, [19] 20 Kryptolebias_marmoratus_Km.CYP2K50, [20] 21 Kryptolebias_marmoratus_Km.CYP2K51, [21] 22 Kryptolebias_marmoratus_Km.CYP2K52, [22] 23 Kryptolebias_marmoratus_Km.CYP2N22, [23] 24 Kryptolebias_marmoratus_Km.CYP2N23, [24] 25 Kryptolebias_marmoratus_Km.CYP2P16, [25] 26 Kryptolebias_marmoratus_Km.CYP2P17, [26] 27 Kryptolebias_marmoratus_Km.CYP2P18, [27] 28 Kryptolebias_marmoratus_Km.CYP2P19, [28] 29 Kryptolebias_marmoratus_Km.CYP2P20, [29] 30 Kryptolebias_marmoratus_Km.CYP2R1, [30] 31 Kryptolebias_marmoratus_Km.CYP2U1, [31] 32 Kryptolebias_marmoratus_Km.CYP2X24, [32] 33 Kryptolebias_marmoratus_Km.CYP2X25, [33] 34 Kryptolebias_marmoratus_Km.CYP2X26, [34] 35 Kryptolebias_marmoratus_Km.CYP2X27, [35] 36 Kryptolebias_marmoratus_Km.CYP2Y9, [36] 37 Kryptolebias_marmoratus_Km.CYP2Z6, [37] 38 Kryptolebias_marmoratus_Km.CYP2Z6.like, [38] 39 Kryptolebias_marmoratus_Km.CYP3A176, [39] 40 Kryptolebias_marmoratus_Km.CYP3A177, [40] 41 Kryptolebias_marmoratus_Km.CYP3B10, [41] 42 Kryptolebias_marmoratus_Km.CYP4F128, [42] 43 Kryptolebias_marmoratus_Km.CYP4T17, [43] 44 Kryptolebias_marmoratus_Km.CYP4T18, [44] 45 Kryptolebias_marmoratus_Km.CYP4V2, [45] 46 Kryptolebias_marmoratus_Km.CYP5A1, [46] 47 Kryptolebias_marmoratus_Km.CYP5A2, [47] 48 Kryptolebias_marmoratus_Km.CYP5A3, [48] 49 Kryptolebias_marmoratus_Km.CYP5A4, [49] 50 Kryptolebias_marmoratus_Km.CYP5A6, [50] 51 Kryptolebias_marmoratus_Km.CYP7A1, [51] 52 Kryptolebias_marmoratus_Km.CYP7C1, [52] 53 Kryptolebias_marmoratus_Km.CYP8A1, [53] 54 Kryptolebias_marmoratus_Km.CYP8A2, [54] 55 Kryptolebias_marmoratus_Km.CYP8A2.like, [55] 56 Kryptolebias_marmoratus_Km.CYP8B1, [56] 57 Kryptolebias_marmoratus_Km.CYP8B14, [57] 58 Kryptolebias_marmoratus_Km.CYP11A1, [58] 59 Kryptolebias_marmoratus_Km.CYP11C1v1, [59] 60 Kryptolebias_marmoratus_Km.CYP17A1, [60] 61 Kryptolebias_marmoratus_Km.CYP17A2, [61] 62 Kryptolebias_marmoratus_Km.CYP19A1, [62] 63 Kryptolebias_marmoratus_Km.CYP19A2, [63] 64 Kryptolebias_marmoratus_Km.CYP20A1, [64] 65 Kryptolebias_marmoratus_Km.CYP21A1, [65] 66 Kryptolebias_marmoratus_Km.CYP24A1, [66] 67 Kryptolebias_marmoratus_Km.CYP26A1, [67] 68 Kryptolebias_marmoratus_Km.CYP26B1, [68] 69 Kryptolebias_marmoratus_Km.CYP26C1, [69] 70 Kryptolebias_marmoratus_Km.CYP27A1, [70] 71 Kryptolebias_marmoratus_Km.CYP27A3, [71] 72 Kryptolebias_marmoratus_Km.CYP27B1, [72] 73 Kryptolebias_marmoratus_Km.CYP27C1, [73] 74 Kryptolebias_marmoratus_Km.CYP46A1, [74] 75 Kryptolebias_marmoratus_Km.CYP46A2, [75] 76 Kryptolebias_marmoratus_Km.CYP46A4, [76] 77 Kryptolebias_marmoratus_Km.CYP46A5, [77] 78 Kryptolebias_marmoratus_Km.CYP51A1, [78] 79 Oryzias_latipes_OlCYP11A2, [79] 80 Oryzias_latipes_OlCYP11C1, [80] 81 Oryzias_latipes_OlCYP17A2, [81] 82 Oryzias_latipes_OlCYP19A1, [82] 83 Oryzias_latipes_OlCYP19A2, [83] 84 Oryzias_latipes_OlCYP1B1, [84] 85 Oryzias_latipes_OlCYP1C1, [85] 86 Oryzias_latipes_OlCYP1D1, [86] 87 Oryzias_latipes_OlCYP20A1, [87] 88 Oryzias_latipes_OlCYP26A1, [88] 89 Oryzias_latipes_OlCYP26B1, [89] 90 Oryzias_latipes_OlCYP26C1, [90] 91 Oryzias_latipes_OlCYP27A1, [91] 92 Oryzias_latipes_OlCYP27C1, [92] 93 Oryzias_latipes_OlCYP2AD7, [93] 94 Oryzias_latipes_OlCYP2K27, [94] 95 Oryzias_latipes_OlCYP2K28, [95] 96 Oryzias_latipes_OlCYP2K29, [96] 97 Oryzias_latipes_OlCYP2K30, [97] 98 Oryzias_latipes_OlCYP2N.like1, [98] 99 Oryzias_latipes_OlCYP2N.like2, [99] 100 Oryzias_latipes_OlCYP2N18, [100] 101 Oryzias_latipes_OlCYP2N20, [101] 102 Oryzias_latipes_OlCYP2P12, [102] 103 Oryzias_latipes_OlCYP2P13, [103] 104 Oryzias_latipes_OlCYP2P15, [104] 105 Oryzias_latipes_OlCYP2U1, [105] 106 Oryzias_latipes_OlCYP2X14, [106] 107 Oryzias_latipes_OlCYP2X20, [107] 108 Oryzias_latipes_OlCYP2Y6a, [108] 109 Oryzias_latipes_OlCYP2Y6b, [109] 110 Oryzias_latipes_OlCYP2Z5, [110] 111 Oryzias_latipes_OlCYP3A38, [111] 112 Oryzias_latipes_OlCYP3A40, [112] 113 Oryzias_latipes_OlCYP3A40.like, [113] 114 Oryzias_latipes_OlCYP3A56.like, [114] 115 Oryzias_latipes_OlCYP3B5, [115] 116 Oryzias_latipes_OlCYP4T12, [116] 117 Oryzias_latipes_OlCYP4V2, [117] 118 Takifugu_rubripes_TrCYP1A1, [118] 119 Takifugu_rubripes_TrCYP1B1, [119] 120 Takifugu_rubripes_TrCYP2AD.like, [120] 121 Takifugu_rubripes_TrCYP2K1, [121] 122 Takifugu_rubripes_TrCYP2K.like1, [122] 123 Takifugu_rubripes_TrCYP2K.like2, [123] 124 Takifugu_rubripes_TrCYP2N.like, [124] 125 Takifugu_rubripes_TrCYP2P.like, [125] 126 Takifugu_rubripes_TrCYP2U1, [126] 127 Takifugu_rubripes_TrCYP2X.like, [127] 128 Takifugu_rubripes_TrCYP2Y.like, [128] 129 Takifugu_rubripes_TrCYP2Z.like, [129] 130 Takifugu_rubripes_TrCYP3A27, [130] 131 Takifugu_rubripes_TrCYP3A30, [131] 132 Takifugu_rubripes_TrCYP3A40, [132] 133 Takifugu_rubripes_TrCYP4T10, [133] 134 Takifugu_rubripes_TrCYP4V2, [134] 135 Takifugu_rubripes_TrCYP11C1, [135] 136 Takifugu_rubripes_TrCYP17A1, [136] 137 Takifugu_rubripes_TrCYP17A2, [137] 138 Takifugu_rubripes_TrCYP19A1, [138] 139 Takifugu_rubripes_TrCYP19A2, [139] 140 Takifugu_rubripes_TrCYP20A1, [140] 141 Takifugu_rubripes_TrCYP26A1, [141] 142 Takifugu_rubripes_TrCYP26C1, [142] 143 Takifugu_rubripes_TrCYP27C1, [143] 144 Danio_rerio_DrCYP1A, [144] 145 Danio_rerio_DrCYP1B1, [145] 146 Danio_rerio_DrCYP1C1, [146] 147 Danio_rerio_DrCYP1C2, [147] 148 Danio_rerio_DrCYP1D1, [148] 149 Danio_rerio_DrCYP2AA1, [149] 150 Danio_rerio_DrCYP2AA2, [150] 151 Danio_rerio_DrCYP2AA3, [151] 152 Danio_rerio_DrCYP2AA4, [152] 153 Danio_rerio_DrCYP2AA6, [153] 154 Danio_rerio_DrCYP2AA7, [154] 155 Danio_rerio_DrCYP2AA8, [155] 156 Danio_rerio_DrCYP2AA9, [156] 157 Danio_rerio_DrCYP2AA11, [157] 158 Danio_rerio_DrCYP2AA12, [158] 159 Danio_rerio_DrCYP2AD2, [159] 160 Danio_rerio_DrCYP2AD3, [160] 161 Danio_rerio_DrCYP2AD6, [161] 162 Danio_rerio_DrCYP2AE1, [162] 163 Danio_rerio_DrCYP2K6, [163] 164 Danio_rerio_DrCYP2K8, [164] 165 Danio_rerio_DrCYP2K16, [165] 166 Danio_rerio_DrCYP2K17, [166] 167 Danio_rerio_DrCYP2K18, [167] 168 Danio_rerio_DrCYP2K19, [168] 169 Danio_rerio_DrCYP2K20, [169] 170 Danio_rerio_DrCYP2K21, [170] 171 Danio_rerio_DrCYP2K22, [171] 172 Danio_rerio_DrCYP2K31, [172] 173 Danio_rerio_DrCYP2N13, [173] 174 Danio_rerio_DrCYP2P6, [174] 175 Danio_rerio_DrCYP2P7, [175] 176 Danio_rerio_DrCYP2P8, [176] 177 Danio_rerio_DrCYP2P9, [177] 178 Danio_rerio_DrCYP2P10, [178] 179 Danio_rerio_DrCYP2R1, [179] 180 Danio_rerio_DrCYP2U1, [180] 181 Danio_rerio_DrCYP2V1, [181] 182 Danio_rerio_DrCYP2X6, [182] 183 Danio_rerio_DrCYP2X7, [183] 184 Danio_rerio_DrCYP2X8, [184] 185 Danio_rerio_DrCYP2X9, [185] 186 Danio_rerio_DrCYP2X10.1v1, [186] 187 Danio_rerio_DrCYP2X10.2v2, [187] 188 Danio_rerio_DrCYP2X12c1, [188] 189 Danio_rerio_DrCYP2X12c2, [189] 190 Danio_rerio_DrCYP2Y3, [190] 191 Danio_rerio_DrCYP2Y4, [191] 192 Danio_rerio_DrCYP3A65, [192] 193 Danio_rerio_DrCYP3C1, [193] 194 Danio_rerio_DrCYP3C2, [194] 195 Danio_rerio_DrCYP3C3, [195] 196 Danio_rerio_DrCYP3C4, [196] 197 Danio_rerio_DrCYP4F3, [197] 198 Danio_rerio_DrCYP4T8, [198] 199 Danio_rerio_DrCYP4V7, [199] 200 Danio_rerio_DrCYP4V8, [200] 201 Danio_rerio_DrCYP5A1, [201] 202 Danio_rerio_DrCYP7A1, [202] 203 Danio_rerio_DrCYP7B1, [203] 204 Danio_rerio_DrCYP7D1, [204] 205 Danio_rerio_DrCYP8A1, [205] 206 Danio_rerio_DrCYP8B1, [206] 207 Danio_rerio_DrCYP8B2, [207] 208 Danio_rerio_DrCYP8B3, [208] 209 Danio_rerio_DrCYP11A1, [209] 210 Danio_rerio_DrCYP11C1, [210] 211 Danio_rerio_DrCYP17A1, [211] 212 Danio_rerio_DrCYP17A2, [212] 213 Danio_rerio_DrCYP19A1A, [213] 214 Danio_rerio_DrCYP19A1B, [214] 215 Danio_rerio_DrCYP20A1, [215] 216 Danio_rerio_DrCYP21A1, [216] 217 Danio_rerio_DrCYP24A1, [217] 218 Danio_rerio_DrCYP26A1, [218] 219 Danio_rerio_DrCYP26B1, [219] 220 Danio_rerio_DrCYP26C1, [220] 221 Danio_rerio_DrCYP27A1.4, [221] 222 Danio_rerio_DrCYP27A3, [222] 223 Danio_rerio_DrCYP27A5, [223] 224 Danio_rerio_DrCYP27A6, [224] 225 Danio_rerio_DrCYP27A7, [225] 226 Danio_rerio_DrCYP27B1, [226] 227 Danio_rerio_DrCYP27C1, [227] 228 Danio_rerio_DrCYP39A1, [228] 229 Danio_rerio_DrCYP46A1.1, [229] 230 Danio_rerio_DrCYP46A1.2, [230] 231 Danio_rerio_DrCYP46A1.3, [231] 232 Danio_rerio_DrCYP46A1.4, [232] 233 Danio_rerio_DrCYP51; TREE Fig._2 = 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