#NEXUS BEGIN TAXA; TITLE Taxa; DIMENSIONS NTAX=33; TAXLABELS Danio_rerio_DrCYP2K6 Danio_rerio_DrCYP2K8 Danio_rerio_DrCYP2K16 Danio_rerio_DrCYP2K17 Danio_rerio_DrCYP2K18 Danio_rerio_DrCYP2K19 Danio_rerio_DrCYP2K20 Danio_rerio_DrCYP2K21 Danio_rerio_DrCYP2K22 Danio_rerio_DrCYP2K31 Kryptolebias_marmoratus_Km.CYP2K38 Kryptolebias_marmoratus_Km.CYP2K39 Kryptolebias_marmoratus_Km.CYP2K40 Kryptolebias_marmoratus_Km.CYP2K41 Kryptolebias_marmoratus_Km.CYP2K42 Kryptolebias_marmoratus_Km.CYP2K43 Kryptolebias_marmoratus_Km.CYP2K44 Kryptolebias_marmoratus_Km.CYP2K45 Kryptolebias_marmoratus_Km.CYP2K46 Kryptolebias_marmoratus_Km.CYP2K47 Kryptolebias_marmoratus_Km.CYP2K48 Kryptolebias_marmoratus_Km.CYP2K49 Kryptolebias_marmoratus_Km.CYP2K50 Kryptolebias_marmoratus_Km.CYP2K51 Kryptolebias_marmoratus_Km.CYP2K52 Oryzias_latipes_OlCYP2K27 Oryzias_latipes_OlCYP2K28 Oryzias_latipes_OlCYP2K29 Oryzias_latipes_OlCYP2K30 Takifugu_rubripes_TrCYP2K1 Takifugu_rubripes_TrCYP2K.like1 Takifugu_rubripes_TrCYP2K.like2 Homo_sapiens_HsCYP2W1 ; END; BEGIN CHARACTERS; TITLE Kryptolebias_Fig._5_CYP_2k; DIMENSIONS NCHAR=527; FORMAT DATATYPE = Protein GAP = - MISSING = ?; MATRIX Danio_rerio_DrCYP2K6 MTMALIEAFLLQGS-PTGAILGALLLFLVIYLFSSSSSS-QDKEKYPPGPKPLPLLGNLHILDLKKTYLSLLELSKRYGPIYTVYLGPKKVVILSGYKIVKEALVNLSEEFGDRDISPIFH-DFNRGYGIAFSNGENWREMRRFALSTLRDFGMGRKRSEELIIEEIKYVKEEFEKFGGNPFETKLPLALAISNIIASIVFSVRFEYSNTKLHRMVGRAYENMKLTGSPSVQIYNMFPWLRPIVAN-RNQIVKNLKDTFKQNEELINGVMKTLDP-FNPRGIVDSFLIRQQKDEESGKTDSLYNSNNLYCTVNNLFGAGTDTTVTTLRWGLLLMAKYPEIQAKVQDEIERVIG-GRQPVVEDRKNLPYTDAVIHEIQRFADISPIGAPRQTTCDVHLNGYFIKK------GTPVFPLLVSVLRDEDEWEMPDSFNPKHFLNKQGQFVKKDAFMPFGAGRRVCIGESLARMELFLFFTSLLQYFRFTPPPGVSEDDLDLTPVVG--FTLNPKPHQLCAVKRS------ Danio_rerio_DrCYP2K8 --MAVMETLLMPVSITG-VLLSAVLLFLVVYLISISS---SSPE-DPPGPKPLPLLGNLHTLDLKNLHVSLWELSKKYGPVFKVHLGRKKVVVLAGYKTVKQALVNQAEEFGERDITPIFQ-DCNQGQGIVFANGERWRTMRRFALSTLRDFGMGKKLSEEKIVDETRYLREVFMKFEGQPFDTTQPVNYAVSNIISAIVYGKRFEYEDPAFQDMVNKANMNIRMIGSAVIQIYNMCPFLGPWIKT-WRQLMKNMESTRRQIQTLADVLQETLNP-LDCRGLIDSFLIRKQNIQETGEKDSSFNDQNLLITVSNLFAAGTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDQVLG-GREPVAEDRKNLPYTDAVIHETQRLANILPLNLPHKTSCDVTFNGYFIKK------GTCVLPLLTSVLRDETEWETPDTFNPQHFLDEKGQLIKRDAFMPFSAGRRACLGESLARMELFLFFTSLLQYFRFSPPPGASEDELDLTPVVG--LTLNPSPHKLCAVIRAERQLN- Danio_rerio_DrCYP2K16 --MAFLDALLH-VSSTG-TLICFLLLLLVAYLLFLRS---QSDENEPPGPKPLPLLGNLLMLDVNKPHLSLCEMAKQFGPVFKVYFGPKKVVVLAGYKAVKQALVNYAEAFGDREIMPLFH-DFTKGHGIIFANGESWREMRRFALTNLRDFGMGKKKIEEKIIEETCHLREEFEKFEGKPFETAQLMNYAASSVISSIVYGRRFEYTDPQLRTMVDRANESVRLSGSASVQLYNMFPFLGPLLKN-WRQLMKNLHLDIEEISELVNGLHQTLNH-QDLRGFVDSFLVRKQYAEDSGEKDSHFHEQNLIYTVGNLFVAGTDTTSTTLRWSLLLMAKYPHIQDRVQEEIDQVIG-GRQPVSEDRKNLPYTDAVIHETQRLANIVPMSIPHMTSSDITFNGYFIKK------GTCIFPLLTSVLWDEDEWETPHIFNPNHFLDEQGRFVKRDAFMPFSAGRRICLGESLARMELFLFFTSLLQYFRFTPPPGVSEDELELTPAVG--FTLNPIAHKLCAVKRL------ Danio_rerio_DrCYP2K17 ---MVVESLLH-FSSVG-TLLGTLLLLLVFYRLSRDSEF-QKKRKDPPGPKPIPLLGNLLTLDLSRPFDSLCELSKTYGNVYQVFLGPKKVVVLIGHKTVKEALVNFADEFGERDITPIFR-ILANDHGILFSNGESWKEMRRFAISNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFEGKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPRFTEMVDRANENIRVSGSASMMLYNIFPWLGPFLNS-KRTVVRNMLKNRAEFMKLITGLQETLNI-HDRRGFVDSFLIRKQSDEQLGKKDTYFHAENLLMTVGNLFAAGTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDRVIG-GRQPVVEDRKKLPYTDAVIHEIQRLANIVPMNLPHVTSCDVTFNGYFIKK------GTTVIPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFIKRDAFMPFSAGRRVCLGESLARMELFLFFASLLQSYRFTTPPGVSEDELDLKGTVG--VTLNPSPHKLCAIKRF------ Danio_rerio_DrCYP2K18 --MAVVESLLQ-FASTG-TLLGALLLFLVLYLVSSGSGS-QKEGKEPPGPKPLPLLGNLLTLDLTRAFDTFFELSKTYGNIFQVYLGPKKTVVLVGYKTVKEALVNHAEAFGDREIGPSFR-IMNDEHGIVFSNGENWKEMRRFALSNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFEGKPIDTTEPVNYAVSNIISSIVYGSRFEYTDPQFTEMVDRANENVRVGGSISMGLYNMFPWLGPFLKN-KRIVVRNIIQSRVQMTKLITALLETLNP-NDPRGFVDSFLIHKLSDEKSGKKNSYFHNENLMMNVANLFVAGTDTTGTTLRWGLMLTAKYPQIQDRVQEEIDRVIG-GRQPAVEDRKKLPYTDAVIHEIQRFANIVPLNLPHTTSCDITFNGYFIKK------GTTVIPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRDAFMPFSAVILTLMSDARAIE--------------------------------------------------------- Danio_rerio_DrCYP2K19 --MAVVESLLQ-FASTG-TLLAALLLFLVLYLVSSGS---QKEGKEPPGPKPLPLLGNLLTLDLTRAFDTFFELSKTYGNVFQVFLGPRKTVVLVGYKTVKEALVNYAEQFGDREIGPGFR-IMNDEHGILFSNGENWKEMRRFALSNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFEGKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPQFTEMVDRANENVRVGGSVSMWFHEMFPWVGPFLKS-KRIIVENIIQSRAQMTKLITALLETLNP-NDPRGFVDSFLTRKLSDEKSGKKDSYFHEENLIMTVTNLFVAGTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDRVIG-GRQPVVEDRKKLPYTDAVIHEIQRLANIVPLSLPHKTTSDITFNGYFIKK------GTTVVPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRDAFIPFSAGRRVCLGESLARMELFLFFTSLLQSYRFTTPPGVSEDELDLKGIVG--ITLNPSPHKLCAIRRS------ Danio_rerio_DrCYP2K20 --MAVVESLLQ-FASTS-ALLGALLLLLVLYLASSGSTS-QKEGKEPPGPKPLPLVGNLLTLDLTRSFDTFFELSKTYGNIFQVFLGHRKTVVLVGYKTVKEALVNYAEVFGDREIGPGFNDMVLCGSGILFSNGENWKEMRRFALSNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFEGKPFDTTQPVNYAVSNIISSIVYGSRFEYIDPRFTEMVARANENVRVGGSFSMMIYNIFPWLGPFLKN-RAVVVKNITQNRAEKKKLITALLETLNP-HDPRGFVDSFLIHKLSDEKSGKKDSYFHEENLMLTVANLFAAGTDTTGTTLRWGLMLMAKYPHIQDRVQEEIDRVIG-GRQPVVDDRKKLPYTDAVIHEIQRLANIVPLSLPHRTTSDITFNGYFIKK------GTTVVPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRDAFMPFSAGRRVCLGESLARMELFLFFTSLLQSYRFTTPPGVSEDALDLKGIVG--ITLNPSPHKLCAIRRS------ Danio_rerio_DrCYP2K21 --MAVVESLLQ-FASTG-TLLGALLLFLVLYLVSSGSES-QKEGKEPPGPKPLPLVGNLLTLDLTRPFDTFFKLSKTYGNVFQVYLGPEKAVVLVGYKTVKEALVNYAEEFGDREIGPGFS-IMNDEHGILFSNGENWKEMRRFALSNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFEGKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPQFTEMVDRANENVRVGGSISMWLYDIFPWLGPFLKN-KRIIVENIIQSRVQMTKLITALLETLNP-NDPRGFVDSFLIRKLSDEKSGKKDSYFHEENLMMTVTNLFIAGTDTTGTTLRWGLMLMAKYPHIQDRVQEEIDRVIG-GRQPVVEDRKKLPYTDAVIHEIQRLANIVPLSLPHRTTSDITFNGYFIKK------GTTVVPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVRRDAFMPFSAGRRVCLGESLARMELFLFFTSLLQSYRFTTPPGVSEDELDLKGIVG--ITLNPSPHKLCAIRRS------ Danio_rerio_DrCYP2K22 MNMALVGALLPGLSFTVGMVVAFLLLFLVISYFSSS----KDQGKYPPGPKPLPLLGNLHILDLKNTYMSLWKLSKQYGPVYTVHMGPRTVVVLSGYKAVKEALVNLSEEFGERDISPIFQ-DFNEGYGIVFSNGENWKEMRRFALSNLRDFGMGKKRGEELITEEIKYLKEEIERFGGKPFETKLPLAMAISNVIALIVYSIRFEYNSPKFHRAIVRANENAKLVGSPSVQLYNMFPWLRLFVIN-QKRVVDNVQESFKQIGEIVNGLKKTLNP-QSPRGIADKFLIQQQKDKESGKTDSLYNSNNFLTTINNLFGAGIDTTVTTLRWGLLLIAKYPEIQAKVHDEIDSVIG-ERQPVPGDRKNLPYTDAVIHEIQRFADILPIGLLRQTSCDVHLNGYLIKK------GTSVFPLIASVLRDENEWETPDSFNPKHFLNKQGQFVKKDAFMPFGAGRRLCIGESLARMELFLFFTSLLQHFCFTPPPGVSEDELDLTPVVG--FTLSPMPHKLCAVKRF------ Danio_rerio_DrCYP2K31 --MALVGALLPGLSFTVGMVVAVLLLFLFISFFSSS----QDEGKYPPGPKPLPLLGNLHILDLKNTYMSLWKLSKTYGPIYTVHMGPRKVVVLSGYKTVKEALVNLSEEFGDRDISPIFH-DFNQGYGIVFSNGENWKEMRRFALSNLRDFGMGRKRSEELIIEEIKQLKEEFEKFRGKPFETKMPIAMAIANIIALIVYSIRFEYTNTKLHCMIGRAYENARLTGSPSVQLYNMFPWLRPFVAN-QKRIINNVKEAFKQSGEIMNGLKNTLNP-QDPRGIADKFLIRQQMDEDSGKTDTYYNSNNLLSTINNLFGAGTDTTVTTLRWGLLIMAKNPEIQAKVQDEIKRVIG-DRQPVPDDRKNLPYTDAVIHEVQRFADVLPIGSPHQTTCDVHLNGYLIKK------GTSVCPLLASVLRDENEWETPDSFNPKHFLNKQGQFVKKDAFMPFGAGRRLCIGESLARMELFLFFTSLLQHFCFTPPPGVSEDELDLTPVVG--FTLNPIPHKLCAVKRS------ Kryptolebias_marmoratus_Km.CYP2K38 --MELLKDFVFFLFSSPTTVVGGVFLLLVFYFVFVGSTS-GDGRKEPPGPRPLPLLGNLLQLDLSRPYRTLCEFSKNYGSVFTVYFGPRKVVVLAGYETVKEALVSYAEEFGDRDISPIFN-DITRGHGILFSNGDSWKEMRRFALYTLRDFGMGKRVVEEKILEECGHLIQMFENQKGKPFDTAHPLNYATSNIICSVVYGSRYEYNDPRFRNMVSRASENIRLSGSAQIQIYNMFPWLFRWIKN-CQLMLKNVEMTIRDMKAIVTQLKETLDP-QRCRGLVDCFLIQKQRDEDSGVKDTHFHEENLIFTATNLFAAGTETTATTLRWSLLLMAKYPHIQDQVREELLRVIG-NRAARVEDRKNLPFTDAVIHETQRLANIVPMSIPHKTSQDVTFQGYFIKK------DTIVIPLLTSVLHDEREWESPHTFNPSHFLDKEGKFIKRGAFLPFSAGRRVCLGESLAKMELFLFFTSLLQRFHFTPPPGVSEDELDLTPAIG--FTIPPSPHKLCAVSHQ------ Kryptolebias_marmoratus_Km.CYP2K39 ----MLEDIFQSP--TSVSLFGVFVALLLLHLLHS-SFS-SQERREPPGPRPLPVFGNLFQVDLKRPDQSLFNLSKKYGPVFQIYLGLKKVVVLAGYRTVKQALVNQAEEFGNIDISPIIY-DFNQGHGIALANGDSWKEMKRFALTTLRDFGMGKKMSEDLIIEECGYLIKEFEQLEGETFDRSQTIDYASSNVVSALTFGKRFDYEDPIFQTMVERNHETLCLIGSASIQLYNLIPWLGPFLKN-WRDFMKNMEDMKADIRKLITDLKETLDP-EVCRCFIDAFLIRKKHLEDSDIIDSHYHDENLLFSVINFFGAGTETTATTLKWSLLYMAKFPHIQDRVQEELSRVVG-SCQIQIDDRKNLPYTNAVIHETQRFANIGPFSVPHATTKDVTLQGYFIKK------GTTVLTLLTSVLYDENEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACLGESHAKMELFLFFASLLQNFHFIPPPGVSEDDLDLKPVLG--CTLNPKPQQLCAVLRR------ Kryptolebias_marmoratus_Km.CYP2K40 ----MLEDIFQSP--TSVSLFGVFVALLLLHLLYS-SFS-SQKRPEPLGPRPLPVFGNLFQVDLKRLDQSLFNLSKTYGPVFQVYFGPKKVVVLAGYRTVKEALLNQAEEFGNREITPLFY-DFNQGHGIVFSNGDSWKEMRRFALTTLRDFGMGKKMSEEIIIEECGYLIKEMEQYGGEAFNNTQAINYAASNVISALMFKKRFEYKDPVFQTMVEKDNETIRLTGSVSIMIYNLCPWLGPFLKN-WRDMMKNIEANKAHLRKLISDLKETLDP-EICRCFVDAFLIQKKHLKDFDEKSSHYHDENLLYSVMNLFAAGTDTTATTLKWGLLYMAKFPHIQDRVQEELSRVVG-SRQIQTEDRKNLPYTDAVIHETQRFANIGPLAIPHKTTRNVTFQGYFIKK------DTTVFPLLTSVLYDENEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACLGESLAKMELFLFFTSLLQRFHFTPPPGVPEDELDLKPVVG--MTLAPKPQQLCAVRRR------ Kryptolebias_marmoratus_Km.CYP2K41 ----MLEDIFQSP--TSVSLFGVFVALLLLHLLHS-TFS-SQKRPEPPGPRPLPVFGNLFQVDLKRLDQSLFNLSKTYGPVFQVYFGPKKVVVLAGYRTVKEALLNQADEFGNREITPILN-DLTQGHGILFSNGDSWKEMRRFALSTLRDFGMGRKMSEEIIIEECGYLIKEMEQYGGEAFNNTQAINYAASNVISALMFGKRFEYKDPVFQNMVERDNETIHLMGTASIMMYDLFPWLGPFFKN-WRNLMKNNEDSLADLKKLIADLKETLDP-EICRCFVDAFLIRKKHLKDDEVKNSHYHDENLLYTVDDLFAAGTDTTATTLKWGLLYMAKFPHIQRCVQEELSRVVG-SRQVRIEDRKNLPYTDAVIHEIQRFANIAPMALPHTTSNDLTFQGYVVKE------GTTVFPLLTSVLYDESEWESPHSFNPPHFLNDEGKFIRRDAFMPFSAGRRACLGESLAKMELFLFFASLLQHFHFTPPPGVSEDEVDLKPVVG--LTLTPKPQRLCAVHRL------ Kryptolebias_marmoratus_Km.CYP2K42 ----MLEDIFQSP--TTVSLFGVFVALLLLHLLYS-SFS-SQNRPEPPGPRPLPVLGNLFQVDLKTIHHSLFILSKKYGSVFQVRLGPKKVVVLAGYRTVKEALVNQAEAFRNIEITPLFH-DINQGHGIILANGDSWKEMRRFALTTLKDFGMGRKMSEEIIIEECGYLIKEFEQFEGKAFSNTQVISYATSNVISALVFGKRFDYKDPFLNIMMERNYENIRLMSSASIQIYNVIPWIGPLLKN-WRDFKKNIGNSLADIKKIIVDLKKTLDP-EVCRCFVDAFLIHKKQLEDSENRNSHYHDNNLLYSVMNLFGAGTETTATTLKWGLLYLVKFPHIQDRVQEELSRVVG-SRQVRIEDRKNLPYTDAVIHEIQRVANVAP-VLPHTTTKDVTLQGYFLKE------GTTVLLLLLSVLSDESEWESPHSFNPSHFLDDEGKFIRRDAFMPFSTGPRACLGESLARMELFLFFASLLQHFRFTLPPGVSEDELDLKPVEG--FTLGPKPQQLCAVQRQ------ Kryptolebias_marmoratus_Km.CYP2K43 ----MLEDIFQSP--TSVSLFGVFVALLLLHLLHS-TFS-SQNRPEPPGPRPLPVFGNLFQVDLKRLDQSLFNLSKKYGPVFQVYFGPKKVVVLAGYRTVKEALVNQADEFGDRDICPLFY-DLNQEYGILFSNGDSWKEMRRFALSALRDFGMGRKMSEEIIIEECGYLIKEFEQFEGEAFDNTQAINYATSNVISALMFGKRFEYKDPVFQTMVERDNETIHLMGTASLVIYNMIPWMGPFLKN-WTDLMKNMENNKADIRKIIADLKQTLDP-ETCRCFIDAFLIRKNQLEDLEMKSSHYRDENLLYSVINLFAAGTDTTATTLKWSLLYMVRFPQIQDRVQEELSRVVG-SRQVRIEDRKNLPYTDAVIHEIQRLANIVPMALPHATSKDITLQGHLIKE------GTTVFPLLTSVLYDESEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACLGESLAKMELFLFFASLLQHFQFTPPPEVSEDELDLKPVVG--LTLAPKPQKLCAVCRL------ Kryptolebias_marmoratus_Km.CYP2K44 ----MFED-LLSP--ISVSLFGVLVALLLLHLLYS-SFS-SNERPEPPGPRPLPLFGNLFQVDLKWLDKSLFELSKKYGPVFQVYFGPKKVVVLAGYKAVKQALVNQAVEFGNRDITPAFY-DLTKSHGIIFSNGDSWKEMRRFALTALRDFGMGKKMSEEIIIEECHYLIEELEQFEGKAFENTKPFNYAASNVISALIFGRRFDYKDAIFQAMVRRENEIIRLTGSASVWIYNAFPWLAPLLKN-WRDLIKNVKGNETDAMKLIADLKESLDP-EVCRCYVEAFLIHKKQLEDSEMKNLYYHDENLLYCVTNLLEAGNDTTANTVKWGLLHMAKNPHVQDRVQEELSRVVG-SRQIRTEDRKNLPYTDAVIHEIQRLANIFPLALPHATSTDVTFQGYFIKQ------GTTVFPLLTSVLYDESEWESPHSFNPSHFLDKEGNFIKRDALMPFSAGRRACLGESLAKMEVFLFFTSLLQHFHFTPPPGVSEDEVDLTPAVG--FSLCPRPQKLCAVRRK------ Kryptolebias_marmoratus_Km.CYP2K45 ----MFED-LQPP--TSVLLLGVIVALLLLHFFCS-NIF-IQERREPPGPRPLPVFGNLFQVDLKWLDKSLFKLSKKYGPVFQVYFGPKKVVVLAGYRTVKQALVNHAVEFGTREITPTFN-DLHKGHGIAFSNGDSWKEMRRFALTTLRDFGMGKKMSEKIIAKECCYLIEEFEEFEGKAFNNTKPINYAATNVISSLMFGKRFDNKDQVFQAMVERDNEIVRLSGTASLWLYNIFPWLGPFFKN-WRDFMKILEDNEKTVKKIIADLKETLDP-EVCRCFVDAFLIRQKHLEDSEITNLHYHDDNLLYSVMNLFEAGNDTTANTVKWGLLYMAKFPHIQDRVQEELSRVVG-SRQVRTEDRKNLPYTDAVIHETQRLAKNLPVGLPYTTSKNVTFQGYFIRA------GTTVFPLLTSVLYDESEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACIGESLARMELFLFFASLLQHFRFTPPPGVSEDEVDLAPVVG--FSLCPRPQKLCAVRRR------ Kryptolebias_marmoratus_Km.CYP2K46 ----MFED-LQS-----VSLFGVFVALLILHFLYS-SFY-SQETQEPPGPRPVPLFGNLFQMDLRRLNQSLFDLSKKYGPVFQVYFGSQKVVVLSGYRTVKQALVNHANEFGDREITPAFF-DLTKGFGVVFSNGDLWKEMRRFALTTLRDFGMGKKRSEDIIVEECQYVINEFEQLEGKPFDNTKFFNYAATNIVSVLMFGKRFDYKDQVFRAMVERDNELIRLLGTASISVYNCFPWLGPFLKD-WRDYIKHVKASREDVKQIIADMKETLDP-EVCRCFVDAFLIRKKQLEESENS--HFNDDNLLYSVINLIEAGNDTTATTLKWSLLYMAKYPHVQDRVQEELSRVVG-SRQVQSEDRKNLPYTDAVIHETQRFADLVPLALPHTTCQDVTLQGYFIKK------GTTVFPLLTSVLYDENEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACLGEGLARMELFLVFTSLLQRFCFTPPPGVSGDEVDLTPVVG--LTLSPRPQKLCAVQRN------ Kryptolebias_marmoratus_Km.CYP2K47 --MGEVDVFLWSFS--PVSLLVAPVFLLLISLYFSSSFSSQKPRPGPPGPRPLPLLGNLLQLDFKRPDKTFVELSKKYGSVFTFYMGLKKAVVLTGYQTVKEALVNYADEFGERDVPAVAK-EANLNHGIVWSNGDSWKEMRRFALTNLKDFGMGKKACEDKIIEESQSLVQEFKKFKGEAFSTDRIITCAVSNIICSVIYGSRFEYEDPAFQTITNRTSIAVKFSASPKIQFYNLYPGIGKLFISARKKMSDIYAANKKDHLKLLNNLKETLNP-QMCRGVADVFMVPDLHLQESGISNSNYTDENLLATVMNLFAAGTETTTTTLRWSLLYMTKYPKIQAKVQEELNTVVG-SRQVQVQDKQNLPFTNAVIHETQRLANIVPLALAHRTSQDVTFQGHFIEK------GTIVFPVLTTVLHDESEWEKPYDFHPAHFLDKDGNFTKRDAFLPFSAGRRMCPGESLAKMELFIFFTTFLQHFRFTPPPGVSEEDLDLTPLPGGTGTLRPQPHKLCAVSLM------ Kryptolebias_marmoratus_Km.CYP2K48 -------------------------------------MSSKESRKEPPGPTPLPLLGNLLQLDLKKPHETLIEFSKKYGSVFTVHFGPQKVVVLAGYRTVKEALVNHDEAFGVRGPLQIVD-ELNQGHGVLWTNGNTWREMRRFSLTNLKDFGMGRKACEDKIIEECQHLVEVLKNFKGEAFDTNQSLNYAVSNIIASMIYGSRFEYEDLEFTSMVDRINRSGTLLGSPSVQVYNLYPFLFKWIAN-RKESHNVAAANRKQNFALIRHLKQTLNP-QMCRGFVDAFLVHKKKLEESGISDNEFSDDNLVMTVANLFAAGSETTSSTLRWGLLFMAKFPDIQGKVREELKRAVG-DRQVQAADRMNLPYTNAVIHETQRMANILPESLPHKTSRDITFHGHLIRK------GTTVYPLLMSVLRDANEWEKPDTFYPPHFLDKDGKFAKRDAFMPFSAGHRMCLGESLARMELFIFFTTLLQHFRFTPAPGVLEEDLDLTPRTG--LSLTPVPHKLCAVSCM------ Kryptolebias_marmoratus_Km.CYP2K49 --MVVLDGLLQSFC--SASLLVALVVLLTYFLFS-SSFSSKNPSKEPPGPRGLPVLGNLLQIDLKRPHHTFQELSKKYGSVFTVYLGPKKVVVLTGYKTVKEALVQYDEEFGDRDSLPILR-EFNKGHGILWSNGDSWREMRRFTLTNLRDFGMGRKVCEDKIIEECQRLTEVFKNFNGKPFETMQPINYAVSNIICSMVYGSRFEYSDPEFTSMVDRTNRNIQLTGSASIQVYNMFPWLFKWLPT-RKEINETFEMNRNQNFSLFHQLRETLNP-EMCRGVVDAFMVRRQNLEKSGVKNNHFHDDNLFMTVTNLFVAGTETTSTTLRWGLLLMAKYPNIQDQVQEELRRVIG-DRQVQVSDRKNMPFTDAVIHETQRLGNIVPAALPHKTSKDFSFHGYFIKK------DTTVYPLLTSVLNDPAEWEKPHTFHPAHFLDKDGNFVKRDAFMPFSAGRRICLGESLARMELFIFFTTLLQHFTFTPAPGISRDELDLTPVGT--FTLNPSPHKLCAVSRM------ Kryptolebias_marmoratus_Km.CYP2K50 --MGILKAFLRSFS--PTSFLGDVAFLLLIYVCFSFIFSSKTYRHGPPGPKPLPLLGNLLQLDFKRLDRTFVEFSKKYGSVFAIYLGQRKVVILAGYQTVKEAFVNYAEEFGDRDVPIVAK-DTNLDHGIAWVNGDSWKEMRRFALTNLKDFGMGKKACEDKIIEEFHKLIKEFKKFKGEAFDMAQLMNFAVCNIICSMVYGNRFEYGDPEFQTVINKTGESLNLLGTPAIKLYTLFPSLGKLLFSARKKLKTTFEDNKRHHLTLLNRLRETLNP-QMFRGVADVFIAPDLHLQESEISTSNYTDENLLAIVINLFAAGTETTLTTLRWGLLFLTKHPKIQAKVQEELNTVVG-SRQVQVQDKQNLPFTNAVIHEIQRLANIVPLALAHSTSKDVIFQGHFIEK------GTIVFPLLTTVLHDESEWEKPYDFHPAHFLDKDGNFTKRDAFLPFSAGRRICPGESLAKMELFIFFTTFLQHFRFTPPPGVSEEDLDLTALPG--GTLRPQPHKLCAVSLK------ Kryptolebias_marmoratus_Km.CYP2K51 ----MFED-LQSP--TSVLFG-VFVALLLRHLFYS-NFS-SNERQEPPGPRPVPLFGNLFQVDLKRLHQSLFNLSKKYGPVFQVYFGPRKVVVLAGYRMIKQALVNQADEFGTRKMIPAFY-DLSKGHGIVFSNGETWKEMRRFALTTLRDFGMGKKMSEKIIIEECGFLIKEFEQFEGKVFNNTKSINYATTNVISALMFGKRFEYKDQVFQGMVERGNEIIHLVGTASLWIYNIFPWLGPFLKN-WRDFMKILEDNEKTVNKIIADLKETLDT-EVCRCFVDAFLIRQKHLEDSEITNLHYHDENLLYSVTNLLEAGNDTTANTLKWGLLYMAKFPHIQDRVQEELSRVVG-TRQIQTEDRKNLPYTDAVIHETQRLANILPISLLHATSKDITLQGYFIKE------GTAVLPLLTSVLYDESEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGRRACLGESLARMELFLFFTSLLQRFRFTPPPGVSGDEVDLTPVVG--FTLSPRPQKLCAVQRK------ Kryptolebias_marmoratus_Km.CYP2K52 ----MLEDIFQSP--TSVSLFGVFVALLLLHLLHS-TFS-SQKRPEPPGPRPLPVFGNLFQVDLKRLDQSLFNLSKTYGPVFQVYFGPKKVVVLAGYRTVKEALLNQADEFGNREITPIFY-DFSEGHGIVFSNGDSWKEMRRFALSTLKDFGMGRKMSEEIIIEECGYLIKEMEQYGGESFNNTQAISYTASNVISALMFAKRFEYKDPVFQSMVEKDKQNIHLAGSASIMIYNFIPWLGPLLKN-RRTMLKNFIDGRADIWRKIEELKETLDP-EVCRCLVDAFLIRKKQLEDSKIKNSHYHDNNLLYSIQGLFVAGTDTTATTLKWGLLYLTKFPHIQDRIQEKLSRVVG-SCQVRIEDRKNLPYTDAVIHETQRFANIGPLALPHTTTKDVTLQGYFIKK------GTTVLTVLTSVLYDENEWESPHSFNPSHFLDDEGKFIRRDAFMPFSAGTLLDLGISL------------------------------------------------------------ Oryzias_latipes_OlCYP2K27 ------MDLLMPLVSSPTTVIGAVFLLLVLYLASAGSTS-RDLGKDPPGPRPLPLLGNLLQLDPRRPHKALCELSKSYGPVFTVYFGIQKVVVLAGYKTVKEALVNNAEEFGDRDITPMFQ-DMNKGHGILFANGESWKELRRFALTTLRDFGMGKRIAEEKILEECDYLIQGLEKHQGNPVDLTCPLNYATSNIISSIVYGSRFDYDDPRFRNLVSRANETIRINGHPLTHLYNMFPRWFRWIKN-RKIILNNVEMTVKDVKDLVKHLKETLNP-SVCRGFVDCFLIKKQKEEDSCVKESHFTEQNLVFSVSNLFAAGTDTTATTLRWGLLLMAKYPHIQDKVHEELAKVLG-GRQVRVDDRKNLPYADAVIHEIQRVANIIPMSIPHKTNRDVTFHGYLIQK------GTTVIPLLASVLNDENEWESPHTFNPHHFLSKEGKFVKRDAFMPFSAGRRACLGESLAKMELFLFFTSLLQRFHFTPPPGVSEEELDLTPAMG--FVLAPSSHELCAVSLQ------ Oryzias_latipes_OlCYP2K28 ----MIQYIFRFMP-ASVSLMWVIVGVLVLLFLYF-QLS-FFNWREPPGPRPLPLLGNLFQVDLKRLDQSLFDLSKKYGPVFVVNFGPKKVVVLAGYRTVKQALVNQAKEFGNREVTPIFY-DFNKEHGILFANGESWNEMRRFALSTLRDFGMGKRISEQNIIEECRWLIEELEKLQGKPFDNTHTISYAVSNVLSGLMFGKRFDYQDPLLQAIVDRDNEIIYLTGTVSILLYNMFPWLGPWLKN-WKTLMKNMEAAKTDMKKIIAELKDTLDP-DTRRCFVDAFLTQKQNLK--EVNGSHYHDDNLLYTVMNLFAAGTDTTATTIEWCLLFMAKYPHIQERVQEELNWVVG-SRQVRIEDRKNLPFTDAVIHESQRLANIAPMAIPHTTSKDVTFQGYFIKK------GTTVLPLLTSVLYDESEWESPRTFNPSHFLDKEGKFLKRGAFMPFSAGRRVCLGESLARMDIFLFFTSLLQHFSFTPPPGVSEDELDLTPVVG--FTLSPQPQGLCAVRRQ------ Oryzias_latipes_OlCYP2K29 --MQILD-FFQSYS--SVSLVGILAVLVLYFISQ-FIFNSEQHGQEPPGPRPLPIIGNLMQIDLKRPYKTLEEFSKTYGPVFTVFFGGEKVVVLAGYKTVKNALVNHDEEFGERAIPPIIQ-ELNKGLGVLWSNGDIWRDIRRFALTNLRDFGMGKKACEDKITEECQYLLEVFKKFKGNAFDTTKPLNYAVSNIICSMVYGSRFEYDDPKFTSMVDRTNRNIQLSGSPTLQAYNMVPWLFKWVAS-RREVHECAAANRKQNQSIFSHLKETLNP-QMCRGFVDAFLVKGQTLEKSGVTNSAFNDENLLMTVIHLFAAGTETTSTTLRWGLLLMAKYPKIQDQVQDELRRVIG-DRMVQVSDRKNLPFTDAVIHEIQRLASIVPTALPHKTSKDVTFQGYFIKK------GTTVFPLLTSVLHDANEWEKPHTFYPAHFLDKDGKFVKREAFIPFSAGRRICLGESLARMELFMFFTTLLQNFCFTPPPGVSKEELSLTPCGG--ITVGPVPHKLCAVPCSE----- Oryzias_latipes_OlCYP2K30 --MGVWDTLLPSLS--PSSLLGAGVLLLLVFLFCPHRTSSQKHRKEPPGPTPIPILGNLHQLDLKRPDQTFMKFAKKYGSVFTVYMGPKKTVVLTGYKTMKEALVNYAEEFGEREAPTVAK-EAHLDCGVVWANGASWREMRRFALSTLRDFGMGKRACEDKIIPECHSLLKEIRKFQGEAFDPTLIINSAVCNVICSMVYGTRFEYDDPDFRTILSRTMKGIQLLGSPGVQLHNLFPRIGRLFLSASKQINQIFTANKNYHLKLL---KETFTP-HTCKSIADAFQLR--QQEEDGFPNSHFHDANILVTIMNLFTAGTETTAATLRWALLFMAKYPKIQDQVQEELSRVME-GRQVTVEDRQRLPFTDAVIHETQRKANIIPLSLLHRTSQDVTFKGFFIEK------GTTVIPVLTSVLYDENEWEKPNIFYPAHFLSKDGKFLKRDAFMPFSAGRRLCLGESLARMELFLFFSTLLQHFRIAPPLGVSEEELDLTPRPG--GTLSPQPHKLCLVSLK------ Takifugu_rubripes_TrCYP2K1 --MGIVDLFLQASS--SVSLLGALALLLFVYFISSVSFSSKKDRKCPPGPKPLPILGNLLQFDLKRPYNTLMKLSKTYGSVFTVYLGPKKVVVLAGYKTVKEALIDHAEEFGERDPIMLVQ-NANHEHGVLWSNGESWKEMRRFALTNLRDFGMGKKACENKIIEECSYLMEELKKWKGEPFDTTHPINYAVSNIICSMVYGNRFEYDDPEFTSLVDRTNTLIQISGSPSVLVYDLFPWIG-PLVNNKKLFQSLFAANKKQNLQLFAAAKEMLNP-QMCRSFVDSFLARQQILEKSGT-NVHFHDENLMSTVMNLFNAGTDTTATTLRWGLLLMAKYPLIQDQVQEELRRVIG-SRQVQVEDRKSLPFTDAVIHETQRLANIVPMALPHKTSQDVTLQGFFIEK------GTTVYPLLTSVLYDETEWEKPLNFYPAHFLDKDGKFVKREAFLPFSAGRRICLGEGLAKMELFIFFSTLLQHFRFRPPPGVSEDHLDLTPRVG--LTLNPSAHKLCAVSCL------ Takifugu_rubripes_TrCYP2K.like1 ---MSLQDFLLSLG--PSTLMGSVALLLLLCLVSR-SFG-RATRREPPGPRALPLLGNLLQLDLSRPHQTLYQLSKKYGPVFKVHFGPRKVVVLAGHKTVKEALVGNAEQFGDRDISPIFY-DMNQGHGILFSNGETWKEMRRFALSTLRDFGMGKRMIEDKIAEECNYLIQKFEDHEGRAFDTSRLANYATSNIISSIVYGSRFDYDDPRFINMVNRANEVIRLTGSAPIQLYNIFPGLANWIKN-RQLLLKQVAMNFRDMTDLIQQLKDTLNP-GVCRGFVDCFLLRKQKAVDSGVIDSLYNEKNLLYSLSNLFGAGTDTTATTLRWGLLLMAKYPRIQDQVQQELSMVVG-NRRVCVEDRKNLPYVDAVIHEIQRLGNIAPMAVPHKTARDVEFRGYFIEKVKYFSEGTTVFPLLTSVLYDENEWETPHTFNPSHFLDKDGKFIKRDAFMPFSAGRRLCLGEGLAKMEIFLFFTSLLQQFRFTPPPGVGEDELDLTPALG--FTLSPSPHKLCAIPRQ------ Takifugu_rubripes_TrCYP2K.like2 ----MIEDLFESS--TSGFLMVAIVSLLLLQLCFS-FIS-REKRKDLPGPEALPLLGNLHQLDLKRLDCHLVQLSQKYGPIFRVYLASKKVVVLAGYTAVKQALVNQAEDFGEREIFPIFH-DFNKGNGILFTNGDQWKEMRRFALMTLKDFGMGKKIEEK-IIKECQYLIEAFEQHQGEAFSNAQVISYATSNIISAIMYGRRFDYKDPTFQAMIERDHEVIHLTGSPSIQIYNIFPWLGPFLKT-WRYIMKKVEINIESTRRIIGEMKETRNP-GTCRCFVDAFLIHKENQEESDVNAHYYHEDNLLHCAMNLFGAGTDTTATTLQWGLLYITKYPHIQDGVQEELRRVVG-NRQVRVEDRKNLPYMEAVIHETQRMANIVPMSLPHRTSRDRHLLGSICPQ------GTMVIPLLTSVLYDESQWEKPHTFNPAHFLDDEGRFVRRDAFMPFSAGRRMCLGEGLARMELFLFFASLLQHFRFKPAPGVSEDSLDLTPVVG--ITLNPLTHKLRAISRF------ Homo_sapiens_HsCYP2W1 ---------------MALLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQ-LIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFP-LALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQL-HRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDD----PEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLLPK------GTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARA--FTMRPRAQALCAVPRP------ ; END; BEGIN TREES; Title CYP_2k; LINK Taxa = Taxa; TRANSLATE [0] 1 Danio_rerio_DrCYP2K6, [1] 2 Danio_rerio_DrCYP2K8, [2] 3 Danio_rerio_DrCYP2K16, [3] 4 Danio_rerio_DrCYP2K17, [4] 5 Danio_rerio_DrCYP2K18, [5] 6 Danio_rerio_DrCYP2K19, [6] 7 Danio_rerio_DrCYP2K20, [7] 8 Danio_rerio_DrCYP2K21, [8] 9 Danio_rerio_DrCYP2K22, [9] 10 Danio_rerio_DrCYP2K31, [10] 11 Kryptolebias_marmoratus_Km.CYP2K38, [11] 12 Kryptolebias_marmoratus_Km.CYP2K39, [12] 13 Kryptolebias_marmoratus_Km.CYP2K40, [13] 14 Kryptolebias_marmoratus_Km.CYP2K41, [14] 15 Kryptolebias_marmoratus_Km.CYP2K42, [15] 16 Kryptolebias_marmoratus_Km.CYP2K43, [16] 17 Kryptolebias_marmoratus_Km.CYP2K44, [17] 18 Kryptolebias_marmoratus_Km.CYP2K45, [18] 19 Kryptolebias_marmoratus_Km.CYP2K46, [19] 20 Kryptolebias_marmoratus_Km.CYP2K47, [20] 21 Kryptolebias_marmoratus_Km.CYP2K48, [21] 22 Kryptolebias_marmoratus_Km.CYP2K49, [22] 23 Kryptolebias_marmoratus_Km.CYP2K50, [23] 24 Kryptolebias_marmoratus_Km.CYP2K51, [24] 25 Kryptolebias_marmoratus_Km.CYP2K52, [25] 26 Oryzias_latipes_OlCYP2K27, [26] 27 Oryzias_latipes_OlCYP2K28, [27] 28 Oryzias_latipes_OlCYP2K29, [28] 29 Oryzias_latipes_OlCYP2K30, [29] 30 Takifugu_rubripes_TrCYP2K1, [30] 31 Takifugu_rubripes_TrCYP2K.like1, [31] 32 Takifugu_rubripes_TrCYP2K.like2, [32] 33 Homo_sapiens_HsCYP2W1; TREE Fig._5 = (((((((((((1:0.12269773,2:0.07567688):0.01699886[%bootstrapFrequency = 0.51 ],3:0.0804712):0.0243525[%bootstrapFrequency = 0.53 ],4:0.09062571):0.01620777[%bootstrapFrequency = 0.77 ],(5:0.15526902,6:0.14235886):0.03120047[%bootstrapFrequency = 0.59 ]):0.04671781[%bootstrapFrequency = 1 ],(7:0.19084115,(8:0.15457996,(9:0.10009294,10:0.10892419):0.04190629[%bootstrapFrequency = 0.98 ]):0.01790594[%bootstrapFrequency = 0.56 ]):0.0442302[%bootstrapFrequency = 0.96 ]):0.05643878[%bootstrapFrequency = 1 ],11:0.22106763):0.07039659[%bootstrapFrequency = 0.99 ],12:0.34463837):0.13110519[%bootstrapFrequency = 0.96 ],(13:0.24440899,(14:0.17979554,15:0.19743947):0.04191637[%bootstrapFrequency = 0.96 ]):0.1076103[%bootstrapFrequency = 1 ]):0.01918323[%bootstrapFrequency = 0.42 ],(((16:0.28656949,17:0.21436132):0.03208787[%bootstrapFrequency = 0.34 ],18:0.18699033):0.05106922[%bootstrapFrequency = 0.84 ],(19:0.21747102,(20:0.29145324,(21:0.10606955,22:0.19799142):0.15109078[%bootstrapFrequency = 1 ]):0.1282182[%bootstrapFrequency = 0.94 ]):0.04366014[%bootstrapFrequency = 0.52 ]):0.16528788[%bootstrapFrequency = 1 ]):0.07608694[%bootstrapFrequency = 0.41 ],(((23:0.11520813,24:0.05346383):0.13293517[%bootstrapFrequency = 1 ],25:0.08843028):0.30083343[%bootstrapFrequency = 1 ],((26:0.23713482,27:0.23417949):0.05049428[%bootstrapFrequency = 0.53 ],(28:0.10350569,(29:0.06847803,(30:0.08048789,(31:0.02830902,32:0.02139106):0.00829028[%bootstrapFrequency = 0.9 ]):0.01986324[%bootstrapFrequency = 0.95 ]):0.06910295[%bootstrapFrequency = 1 ]):0.17431064[%bootstrapFrequency = 1 ]):0.00950521[%bootstrapFrequency = 0.88 ]):0.0339569[%bootstrapFrequency = 0.84 ]):0.33245798[%bootstrapFrequency = 0.0 ],33:1.09479335); END;