#NEXUS [written Fri Dec 22 00:22:30 KST 2017 by Mesquite version 3.31 (build 859) at mhchoi/192.168.0.2] BEGIN TAXA; TITLE Taxa; DIMENSIONS NTAX=233; TAXLABELS Danio_rerio_CYP19A1A Takifugu_rubripes_CYP19A1 Kryptolebias_marmoratus_CYP19A1 Oryzias_latipes_CYP19A1 Danio_rerio_CYP19A1B Takifugu_rubripes_CYP19A2 Kryptolebias_marmoratus_CYP19A2 Oryzias_latipes_CYP19A2 Danio_rerio_CYP20A1 Takifugu_rubripes_CYP20A1 Kryptolebias_marmoratus_CYP20A1 Oryzias_latipes_CYP20A1 Danio_rerio_CYP51 Kryptolebias_marmoratus_CYP51A1 Danio_rerio_CYP11C1_ORF Takifugu_rubripes_CYP11C1 Kryptolebias_marmoratus_CYP11C1v1 Oryzias_latipes_CYP11C1 Danio_rerio_CYP11A1 Kryptolebias_marmoratus_CYP11A1 Oryzias_latipes_CYP11A2 Danio_rerio_CYP24A1 Kryptolebias_marmoratus_CYP24A1 Danio_rerio_CYP27C1 Takifugu_rubripes_CYP27C1 Kryptolebias_marmoratus_CYP27C1 Oryzias_latipes_CYP27C1 Danio_rerio_CYP27B1 Kryptolebias_marmoratus_CYP27B1 Danio_rerio_CYP27A3 Kryptolebias_marmoratus_CYP27A3 Danio_rerio_CYP27A7 Danio_rerio_CYP27A1.4 Danio_rerio_CYP27A5 Danio_rerio_CYP27A6 Kryptolebias_marmoratus_CYP27A1 Oryzias_latipes_CYP27A1 Danio_rerio_CYP26A1 Takifugu_rubripes_CYP26A1 Kryptolebias_marmoratus_CYP26A1 Oryzias_latipes_CYP26A1 Danio_rerio_CYP26B1 Kryptolebias_marmoratus_CYP26B1 Oryzias_latipes_CYP26B1 Danio_rerio_CYP26C1 Takifugu_rubripes_CYP26C1 Kryptolebias_marmoratus_CYP26C1 Oryzias_latipes_CYP26C1 Kryptolebias_marmoratus_CYP1C2 Kryptolebias_marmoratus_CYP1C1 Oryzias_latipes_CYP1C1 Danio_rerio_CYP1C1 Danio_rerio_CYP1C2 Danio_rerio_CYP1B1 Takifugu_rubripes_CYP1B1 Kryptolebias_marmoratus_CYP1B1 Oryzias_latipes_CYP1B1 Kryptolebias_marmoratus_CYP1A Danio_rerio_CYP1A Takifugu_rubripes_CYP1A1 Danio_rerio_CYP1D1 Kryptolebias_marmoratus_CYP1D1 Oryzias_latipes_CYP1D1 Danio_rerio_CYP2U1 Takifugu_rubripes_CYP2U1 Oryzias_latipes_CYP2U1 Kryptolebias_marmoratus_CYP2U1 Danio_rerio_CYP2X10.1v1 Danio_rerio_CYP2X10.2v2 Danio_rerio_CYP2X12c2 Danio_rerio_CYP2X12c1 Danio_rerio_CYP2X9 Danio_rerio_CYP2X8 Danio_rerio_CYP2X7 Danio_rerio_CYP2X6 'Takifugu rubripes CYP2X-like' Oryzias_latipes_CYP2X20 Kryptolebias_marmoratus_CYP2X27 Kryptolebias_marmoratus_CYP2X25 Kryptolebias_marmoratus_CYP2X26 Oryzias_latipes_CYP2X14 Kryptolebias_marmoratus_CYP2X24 Danio_rerio_CYP2AA12 Danio_rerio_CYP2AA11 Danio_rerio_CYP2AA6 Danio_rerio_CYP2AA8 Danio_rerio_CYP2AA9 Danio_rerio_CYP2AA3 Danio_rerio_CYP2AA4 Danio_rerio_CYP2AA7 Danio_rerio_CYP2AA1 Danio_rerio_CYP2AA2 Danio_rerio_CYP2R1 Kryptolebias_marmoratus_CYP2R1 'Takifugu rubripes CYP2K-like2' Oryzias_latipes_CYP2K28 Kryptolebias_marmoratus_CYP2K42 Kryptolebias_marmoratus_CYP2K39 Kryptolebias_marmoratus_CYP2K52 Kryptolebias_marmoratus_CYP2K43 Kryptolebias_marmoratus_CYP2K40 Kryptolebias_marmoratus_CYP2K41 Kryptolebias_marmoratus_CYP2K46 Kryptolebias_marmoratus_CYP2K44 Kryptolebias_marmoratus_CYP2K45 Kryptolebias_marmoratus_CYP2K51 Danio_rerio_CYP2K6 Danio_rerio_CYP2K22 Danio_rerio_CYP2K31 Oryzias_latipes_CYP2K30 Kryptolebias_marmoratus_CYP2K47 Kryptolebias_marmoratus_CYP2K50 Kryptolebias_marmoratus_CYP2K48 Takifugu_rubripes_CYP2K1 Kryptolebias_marmoratus_CYP2K49 Oryzias_latipes_CYP2K29 'Takifugu rubripes CYP2K-like1' Oryzias_latipes_CYP2K27 Kryptolebias_marmoratus_CYP2K38 Danio_rerio_CYP2K16 Danio_rerio_CYP2K8 Danio_rerio_CYP2K17 Danio_rerio_CYP2K18 Danio_rerio_CYP2K20 Danio_rerio_CYP2K19 Danio_rerio_CYP2K21 Danio_rerio_CYP2Y3 Danio_rerio_CYP2Y4 'Takifugu rubripes CYP2Y-like' Kryptolebias_marmoratus_CYP2Y9 Oryzias_latipes_CYP2Y6a Oryzias_latipes_CYP2Y6b Danio_rerio_CYP2AE1 Danio_rerio_CYP2AD6 Danio_rerio_CYP2AD2 Danio_rerio_CYP2AD3 'Takifugu rubripes CYP2AD-like' Oryzias_latipes_CYP2AD7 Kryptolebias_marmoratus_CYP2AD12 'Kryptolebias marmoratus CYP2AD12-iso' Danio_rerio_CYP2V1 'Takifugu rubripes CYP2Z-like' 'Oryzias latipes CYP2N-like2' Kryptolebias_marmoratus_CYP2Z6 'Kryptolebias marmoratus CYP2Z6-like' Danio_rerio_CYP2P6 Danio_rerio_CYP2P7 Danio_rerio_CYP2P10 Danio_rerio_CYP2P8 Danio_rerio_CYP2P9 'Takifugu rubripes CYP2P-like' Kryptolebias_marmoratus_CYP2P19 Kryptolebias_marmoratus_CYP2P20 Kryptolebias_marmoratus_CYP2P16 Kryptolebias_marmoratus_CYP2P17 Kryptolebias_marmoratus_CYP2P18 Oryzias_latipes_CYP2P15 Oryzias_latipes_CYP2P12 Oryzias_latipes_CYP2P13 Danio_rerio_CYP2N13 'Takifugu rubripes CYP2N-like' Kryptolebias_marmoratus_CYP2N22 'Oryzias latipes CYP2N-like1' Oryzias_latipes_CYP2Z5 Kryptolebias_marmoratus_CYP2N23 Oryzias_latipes_CYP2N18 Oryzias_latipes_CYP2N20 Danio_rerio_CYP21A1 Kryptolebias_marmoratus_CYP21A1 Danio_rerio_CYP17A1 Kryptolebias_marmoratus_CYP17A1 Takifugu_rubripes_CYP17A1 Danio_rerio_CYP17A2 Takifugu_rubripes_CYP17A2 Kryptolebias_marmoratus_CYP17A2 Oryzias_latipes_CYP17A2 Kryptolebias_marmoratus_CYP46A1 Kryptolebias_marmoratus_CYP46A2 Kryptolebias_marmoratus_CYP46A4 Kryptolebias_marmoratus_CYP46A5 Danio_rerio_CYP46A1.3 Danio_rerio_CYP46A1.1 Danio_rerio_CYP46A1.2 Danio_rerio_CYP46A1.4 Danio_rerio_CYP5A1 Kryptolebias_marmoratus_CYP5A6 Kryptolebias_marmoratus_CYP5A2 Kryptolebias_marmoratus_CYP5A3 Kryptolebias_marmoratus_CYP5A4 Kryptolebias_marmoratus_CYP5A1 Takifugu_rubripes_CYP3A30 Takifugu_rubripes_CYP3A27 Kryptolebias_marmoratus_CYP3B10 'Oryzias latipes CYP3A56-like' 'Oryzias latipes CYP3A40-like' Oryzias_latipes_CYP3B5 Danio_rerio_CYP3C1 Danio_rerio_CYP3C4 Danio_rerio_CYP3C2 Danio_rerio_CYP3C3 Takifugu_rubripes_CYP3A40 Danio_rerio_CYP3A65 Kryptolebias_marmoratus_CYP3A176 Kryptolebias_marmoratus_CYP3A177 Oryzias_latipes_CYP3A38 Oryzias_latipes_CYP3A40 Danio_rerio_CYP4V7 Danio_rerio_CYP4V8 Kryptolebias_marmoratus_CYP4V2 Oryzias_latipes_CYP4V2 Takifugu_rubripes_CYP4V2 Danio_rerio_CYP4T8 Takifugu_rubripes_CYP4T10 Oryzias_latipes_CYP4T12 Kryptolebias_marmoratus_CYP4T17 Kryptolebias_marmoratus_CYP4T18 Danio_rerio_CYP4F3 Kryptolebias_marmoratus_CYP4F128 Danio_rerio_CYP39A1 Kryptolebias_marmoratus_CYP8B1 Kryptolebias_marmoratus_CYP8B14 Danio_rerio_CYP8B1 Danio_rerio_CYP8B2 Danio_rerio_CYP8B3 Danio_rerio_CYP8A1 Kryptolebias_marmoratus_CYP8A1 Kryptolebias_marmoratus_CYP8A2 'Kryptolebias marmoratus CYP8A2-like' Danio_rerio_CYP7B1 Kryptolebias_marmoratus_CYP7C1 Danio_rerio_CYP7D1 Danio_rerio_CYP7A1 Kryptolebias_marmoratus_CYP7A1 ; END; BEGIN CHARACTERS; TITLE Character_Matrix; DIMENSIONS NCHAR=804; FORMAT DATATYPE = Protein GAP = - MISSING = ?; MATRIX Danio_rerio_CYP19A1A ------SHIPG------------P-SFFFGLGPV-------VSYCRF-----IWSGI--------GTASNYYN----SKYGDI--VRVWINGEETLI-LSRSSAVYHVLRKSLYT---SRFGSKLGLQCIG-----MHE--QG---IIFNSNVALWKKVRAFYAKALTGPGLQR---------TMEICTTSTNSHLDDLSQL-----------TDAQGQ-----LDILNLLRCIVVDVSNRLFLGVPLN-----EHDL------LQKIH----KYFDTWQTVLIKP--DVY--FRLDWL------------HKKHKRDA--QELQDAITALIEQKKVQLAHAEK------------LDH-L-----DFTAE-L---IFAQ--------------------------------------------------SHGELSAENVRQCVLEMVIAAPDTLSISLFFMLLLLKQNPDVELKILQEMDSV--L----------------------------------------------------------------AGQ----------SLQHSH-LSKLQILESFINESL-RFHPVVDFTMRRALDDDVI--EG--YNVKK------G-----------TNIILNVGR--MHRSEFFSKPNQFSLD------NF-------HK-----------NVPSRFFQPFGSG-----------PRSCVGKHIAM-VMMKSILVALLSRFSVC----PMKACTVENIPQTNNL--------SQQPVEEPS----SLSV--Q--L-----ILRNT- Takifugu_rubripes_CYP19A1 ------KSVPG------------P-SFCLGFGPL-------LTYVRF-----IWTGI------G-TASNYYNK-----KYGDI--VRVWVNGEETLV-ISRASAVHHVLKSWQYT---SRFGSKQGLSCIG-----MNE--RG---IIFNNNVTEWRKIRGYFTKALTGPAVQN---------TVEVCNSSTQAHLDRLEDL------------AQ--------VDVLSLLRCTVVDISNRLFLDIPIN-----EKEL------LLKIH----KYFDTWQTVLIKP--DIY--FKFGWI------------HQKHKTAA--RELQEAIEGLVEQKRRDLEQADK------------LEN-I-----NFTAE-L---LFAQ--------------------------------------------------NHGELSAENVMQCVLEMVIAAPDTLSVSLFFMLLLLKQNPDVELQLLQEIDAV--V-G---------------------------------------------------------------ER----------QLQNGD-LQKLRVLETFINECL-RFHPVVDFTMRRSLSDDVI--EG--YRVPK------G-----------TNIILNTGH--MHRTEFFLRPTEFCLQ------NF-------EK-----------NAPRRYFQPFGSG-----------PRACVGKHIAM-VMMKSILVTLLSQYSVC----PHEGLTLDCLPQTNNL-----------SQQPVEHQEEAQQLSMR--F-----LPRQR- Kryptolebias_marmoratus_CYP19A1 ------KTIPG------------P-SFCLGLGPL-------LSYLRF-----IWTGI------DGTASNYYNK-----KYGDM--VRVWINGEETLI-LSRASAVHHVLRSGKYT---SRFGSQQGLRCLG-----MNE--RG---IIFNNNVTLWKNIRTYFAKALTGPNMQQ---------TVEVCVSSTQSHLDDLDSL------------TH--------VDVLSLLRCTVVDISNRLFLDVPLD-----EKEL------LLKIQ----KYFDTWQSVLIKP--DVY--FRFSWI------------QQKHKAAA--QELQDAIEGLVEQKRREMEQAEK------------LDN-I-----NFAAD-L---IFAQ--------------------------------------------------NHGELSADNVRQCVLEMVIAAPDTLSISLFFMLLLLKQNPDVELQLLQEIDAV--V-G---------------------------------------------------------------EE----------QLQNQD-LQKLQVLESFINECL-RFHPVVDFTMRRALSDDI----G--FRVRK------G-----------TNIILNTGR--MHRTEFFHRAQEFSLE------NF-------QK-----------NAPRRYFQPFGSG-----------PRACVGKHIAM-VMMKSILVTLLGQFSVC----PPRDLTLDCLPQTNNL-----------SQQPVEHQEEAGGLSMR--F-----LPRQR- Oryzias_latipes_CYP19A1 ------KTIPG------------P-SFCLGLGPL-------MSYLRF-----IWTGI-------GTASNYYNN-----KYGDI--VRVWINGEETLI-LSRASAVHHVLKNRKYT---SRFGSKQGLSCIG-----MNE--KG---IIFNNNVALWKKIRTYFTKALTGPNLQQ---------TVEVCVTSTQTHLDNLSSL------------SY--------VDVLGFLRCTVVDISNRLFLGVPVD-----EKEL------LQKIH----KYFDTWQTVLIKP--DIY--FKFSWI------------HQRHKTAA--QELQDAIESLVERKRKEMEQAEK-------------LDNI-----NFTAE-L---IFAQ-----------------------------------------------G---HGELSAENVRQCVLEMVIAAPDTLSISLFFMLLLLKQNPHVELQLLQEIDTI--V-G---------------------------------------------------------------DS----------QLQNQD-LQKLQVLESFINECL-RFHPVVDFTMRRALFDDII--DG--HRVQK------G-----------TNIILNTGR--MHRTEFFHKANEFSLE------NF--QKN--TP--------------RRYFQPFGSG-----------PRACVGRHIAM-VMMKSILVTLLSQYSVC----PHEGLTLDCLPQTNNL-----------SQQPVEHHQEADHLSMT--F-----LPRQR- Danio_rerio_CYP19A1B ------SALPG------------P-GWWLGLGPV-------LSYSRF-----LWMGI-------GTACNYYNE-----KYGSI--ARVWINGEETVI-LSKSSAVYHVLKS--NNYT-GRFASAKGLQCIG-----MFE--QG---IIFNSNIAKWKKVRTYFTKALTGPGLQK---------SVEVCVSATNRQLDVLQEF-----------TDASGH-----VDVLNLLRCIVVDVSNRLFLRIPLN-----EKEL------LIKIH----RYFSTWQTVLIQP--DIF--FKLDFV------------YRKYHLAA--KELQDEMGKLVEQKRQAINNTEK------------LDE-M-----DFATE-L---IFAQ--------------------------------------------------NHDELSVDDVRQCVLEMVIAAPDTLSISLFFMLLLLKQNSAVEEQIVQEIQSQ--I-G---------------------------------------------------------------SR----------DVESAD-LQKLNVLERFIKESL-RYHPVVDFIMRQSLEDDYI--DG--YRVAK------G-----------TNLILNIG--RMHKTEFFKKPNEFSLE------NF--ENT--VP--------------SRYFQPFGCG-----------PRACVGKHIAM-VMTKAILVTMLSRFTVC----PRHGCTISTIRQTNNL-----------SMQPVE--EDPDCL--AMRF-----IPRAQ- Takifugu_rubripes_CYP19A2 ------QHVPG------------P-LFLAGLGPL-------LSYCRF-----MWTGI--------GTACNFYN----NKYGSL--VRVWINGEETLI-LSRSSAVYHVLRSAHYT---ARFGSRAGPECIG-----MEG--QG---VIFNSDVELWRRARVYFSKALTGPGLQR---------TVGVCVTSTAKHLDCLVDM-----------TDASGH-----VDALNLLRAIVVDISNRLFLRVPLN-----EKDL------LTKIH----NYFETWQAVLIKPDIFFK----IGWL------------FDKHRRAA--QELQDTMAALLKVKRKLVHEAEK------------LDDVL-----DFATE-----LILA-------------------------------------------------QEAGEFSADNVRQCALEMVIAAPDTLSISLFFMLMLVKQHPDVELRIVEELSTVSRT-G--------------------------------------------------------------EEG----------EENID--YQRLKVMESFINESM-RFHPVVDFTMRKALEDDTI--EG--IRIRK------G-----------TNIILNIG--LMHKTEFFPKPREFSLT------NF-------EQ-----------TVPSRFFQPFGCG-----------PRSCVGKHIAM-VMMKAILATLLSRYTVC----PRHGCTLTSIRQTNNL-----------SQQPVE---DEHSLAMR--F-----IPRTI- Kryptolebias_marmoratus_CYP19A2 ------SHTPG------------P-SFLAGLGPI-------LSYSRF-----IWTGI-------GTACNYYNR-----KYGSI--VRVWINGEETFI-LSKSSAVYHVLRS--DNYI-CRFGSRRGLKCIG-----MEG--QG---IIFNSDVPLWKKVRTYFSKALSGPSLRR---------TVRICVSSTAKHLDSLQDV-----------TDPSGH-----VDALSLLRAIVVDISNRLFLRVPLN-----EKDL------LMKIQ----NYFETWQTVLIKPGVFFK----LGWL------------YNKHKRAA--QELQDEMESLLEVKRKMIDDAEK------------LDDDR-----DFATE-----LIFA-------------------------------------------------QNHGELSADNVRQCVLEMVIAAPDTLSISLFFMLMLLKQNPDVELKMVEEMNAA--L----------------------------------------------------------------NGK----------AIEDVD-YEGLKVMERFISECL-RFHPVVDFTMRKALEEDNI--DG--MKIRK------G-----------TDIILNLG--LMHKTEFFPKPKEFNLT------NF-------DN-----------TVPSRFFQPFGCG-----------PRSCVGKHIAM-VMMKATLITLLSRYTVC----PRQGCTLDSIRQTNNL------------SQQPVEDELGLAM--R--F-----IPRTQ- Oryzias_latipes_CYP19A2 ------SHIPG------------P-SFLAGLGPV-------LSYARF-----IWMGI------G-TACNYYNK-----KYGSI--VRVWINGEETLI-LSRSSEVYHVLKSAHYT---SRFGSQKGLQCIG-----MDG--RG---IIFNCDVPLWKKTRMYFSKALSGPSLQR---------TVGICVSSTAKHLARLQDV-----------TDSSGH-----VDALNLLRAIVVDISNRLFLRVPLN-----EKEL------LQKIH----NYFETWQAVLIKPDVFFK----MGWL------------YNKHKRAA--QELQDSMESLLEIKRKMINEAEK------------LDDDL-----DFATE-----LIFA-------------------------------------------------QNHGELSADNVRQCVLEMVIAAPDTLSISLFFMLMLLKQNPDVELQVVEEMNSV--L----------------------------------------------------------------DEK----------ATESID-YESLRVLESFINESM-RFHPVVDFTMRKALEDDEI--EG--TKIRR------G-----------TNIILNIG--LMHKTEFFPKPTEFSLA------NF-------EK-----------TVPSRFFQPFGCG-----------PRSCVGKHIAM-VMMKAILITLLSRYTVC----PRQGCTLNSIRQTNNL-----------SQQPVE-DEHSLTM--R--F-----IPRTS- Danio_rerio_CYP20A1 ------SGVPG------------LNPTEEKDGNL----------QDI-----VNKGS------LHEFLVGLHD-----EFGSV--ASFWFGARPVVS-LGAVNQLRQHINPNWTT---DSFETMLKSLLGY-----QSG--SG---VGLTESMM-----RKKVYEGAINKTLEN---------NFPLLLQQVEELVDKWASY------------PKSQH-----MPLCAHLLGLAMKAVTQLAMGSRFR-----DDAE------VIRFR----KNHEAIWSEIGKGYLD----GSLEKSSS----------RKAHYESA--LAEMESVLKSVAKQRPGQGSSQS----------------------SFVNY-----LLQA-----------------------------------------------------NLTERQVMEDGMVFTLAGCVITANLCIWAVHFLSVSEAVQDRLYHELVEV--L-G---------------------------------------------------------------DE----------PVSLEK-IPQLRYCQQVLNETV-RTAKLTP-VAARLQEVEGKV-DQ--HVIPK------E-----------TLVIYALGV-VLQDADTWSLPYRFNPD------RF--AEE------SVM------K--SFSLLGFS-G-----------SQACPELRFAY-TVATVLLSTLVRRLRMH----RVDG---QVVEARYEL-----------VTTPKD----DTWI--T--V-----SKRN-- Takifugu_rubripes_CYP20A1 ------SGIPG------------LNPTDEKDGNL----------QDI-----VGRGS------LHEFLVSLHQ-----EFGPV--ASFWFGSRPVVS-LGSLQQLRQHINPNHST---DSFETMLKSLLGY-----HSG--GG-----AASTDS---IIRKKVYQGAIDTTLKN---------NFPLVLKLVDELVGKWKSFP----------EDQHTP-----LCAHQLV--LAMKTITQLALGESFS-----EDAR------VIAFR----KNHDVIWSEIGKGYMDG---SLEKSTSR----------KGHYEKAL--SEMESTLLSVVKERKSQRNKS------------------------VFVDS-----LIQS-----------------------------------------------------TLTERQIMEDCMVFMLAGCAITANLCIWALHFL?TSEEVQDRLYKEFEEV--L-G---------------------------------------------------------------SS----------PVSLEK-IPQLRYCQQVLNETL-RTAKLTP-IAARLQEVEGKV-DQ--HLIPK------E-----------SLVIYALGV-ILQDSDTWNAPYRFDPD------RF--EEE------SVK------K--SFHLLGFS-G-----------SQTCPELRFAY-TVATVLLSVLVRQLKLH----RLKD---TLMEVRSEL-----------VSTPRD----ETWI--T--F-----NLRN-- Kryptolebias_marmoratus_CYP20A1 ------SGIPG------------LNPTDEKDGNL----------QDI-----VNKGS------LHEFLVSLHQ-----EFGSV--ASFWFGGRPVVS-LGSVKPLQQHINPNHTT---DSFETMLKSLLSY-----QSG--MG-------GGPN-ESVIRKKLYESAINNSLKN---------NFSVVLKVVEELVGKWSSFP----------EAQ--H-----IPLCAHLLGLALKTVTQLGLGERFR-----CDAE------VISFR----KNHDAIWSEIGKGYMDG---SLEKSASR----------KAHYEAAL--SEMESMLLSVSKERKAQRKQT------------------------VFVDG-----LLQS-----------------------------------------------------SLTERQIMEDCMVFTLAGCVITANLCIWALHFLSTSEEVQDKLYKELEDV--L-G---------------------------------------------------------------SD----------PVSLDK-IPQLRYCQQVLNETV-RTAKLTP-VAARLQEVEGKV-DQ--HVIPK------E-----------TLVIYALGV-VLQDPDTWSTPYRFDPD------RF--EEE------SAR------K--SFCLLGFS-G-----------NQTCPELGFAY-TVATVLLSTVVRRLKLH----QLEG---QVAEVRSEL-----------VSSPKE----ETWI--T--V-----SSRS-- Oryzias_latipes_CYP20A1 ------SGVPG-----------LF-PTDEKDGNL----------QDI-----VGRGS------LHEFLVSLHE-----QFGPV--ASFWFGRQPVVS-LGSVDPLRQHINP-------NHTTDSFETMLKS-----LLGYQAG---AGGGANES---VMRKKLYESAINNAVKN---------SFPAVLKVAEELVDKWSSVP----------EDQ--H-----IPLCAHLLGLALKTVTQLALGERFK-----DDAE------VISFR----KNHEAIWSEIGKGYMDG---SLEKSSSR----------KRHYESAL--SDMEATLLAVAKDRKAQRRQT------------------------AFVDA-----LLQS-----------------------------------------------------GLTERQIMEDCMVFTLAGCVITANLCIWALHFLSTAEDVQEKLCQEVEDL--F-G---------------------------------------------------------------SD----------PVSLDR-IPQLKYCQQVLNETV-RTAKLTP-VAARLQEVEGKV-GQ--HVIPK------E-----------TLVIYALGV-VLQDADTWSTPYRFDPD------RF--QDE------SAR------K--SFCLLGFS-G-----------SQTCPELRFAY-TVATVLLATLVRRLKLR----PLKG---QAPEVRSEL-----------VSTPKE----ETWI--T--V-----SSRRG- Danio_rerio_CYP51 ------KYPPH-----------IP-SSLPFLGQA----------VAF-----GRSPI--------EFLEKAYE-----QYGPV--VSFTMVGKTFTY-LLGSDAAALMFNS--KN---EDLNAEDVYARLT-TP--VFG--KG---VAYDVPNPLFLEQKKMLKTGLNIAQFKQ---------HVEIIEEETKDYFRRWGE------------SGE--------RNLFDALSELIILTASRCLHGCEIR------------------------SLLDERVAQLYADLDGGF--THAAWLLPGWLPLP---SFRRRDRAH--LEIKKIFYNVIKKRREDTEKHD-----------------------DILQT-L---IDAT------------------------------------------------YKDGRPLSDDEIAGMLIGLLLAGQHTSSTTSAWMGFFLARDRALQERCYSEQKSV--C-G--------------------------------------------------------------EEL----------PPLHYDQLKDLSLLDRCLKETL-RLRPPIM-TMMRMAKTPQKV-GE--YTIPP------G-----------HQVCVSPTV-NHRLQDTWAERLDFDPD------RY--LHD--NP--AAG------E--KFAYIPFGAG-----------RHRCIGENFAY-VQIKTIWSTLLRMFDFE----LVDG---HFPPVNYTT-----------MIHTPH----NPII--R--Y-----TRRNT- Kryptolebias_marmoratus_CYP51A1 ------KHPPY-----------IP-SSIPFLGHA----------IAF-----GKSPI--------EFLENAYE-----KYGPV--FSFTMVGKTFTF-LLGSEAAALMFSS--KN---DELNAEDVYSKLT-TP--VFG--KG---VAYDVPNHVFLEQKKMFKTGLNSVRFKQ---------HVKLVEAETIEYFQRWGD------------SGE--------RNLFEALSELIILTASSCLHGQEIR------------------------SMLNERVAQLYADLDGGF--SHAAWLLPSWLPLP---SFRKRDKAH--VEIKKMFFKVIEKRRSSGEKVD-----------------------DILQT-L---IDAT-----------------------------------------------Y-KDGQPMNDNEVAGMLIGLLLAGQHTSSTTSAWLGFFLARDKALQEHCYAEQKAV--C-G--------------------------------------------------------------EHL----------PPLDYDQLKDLSLLERCLKETL-RLRPPIM-TMMRMARTPQAA-VG--YTIPV------G-----------HQVCVSPTV-NHRLRDTWVERMDFQPD------RY--LNN--NP--AAG------E--KFAYIPFGAG-----------RHRCIGENFAY-VQIKTIWSTLLRMYEFD----LVDG---YFPTINYTT-----------MIHTPH----NPII--R--Y-----KRRKQ- Danio_rerio_CYP11C1_ORF ------SRSAG----AARLFQEIPDTGSNGWMNL----------LRF-----WRDGRFSRM--H-KHMEESFR-----RLGPI--YREHLGSQSSVN-IMLPMDTGELFRS--E----GLHPRRMTLQPWA-THRETRRHSKG---VFLKNGTE-WRADRLLLNREVMVSSSVH--------RFLPLLDEVAQDFCRSLRRR---VQADGFEKAGQHTL----TLDPSPDLFRFALEASCHVLYGERIGL---FSSCP------SDESE----RFISAVERMLATTPPLLY---LPPRLLL-RLRAS---LWTTHATAW--DDIFSHAEQRIQRSYQRLQARPS----------------------AAPDCSFPGVLGKL-------------------------------------------------MEAGQLSLELIRANITELMAGGVDTTAVPLQFALFELARNPDVQECVRAQVLSS--W-Q--------------------------------------------------------------QAS----------GDPLKA-LQGAPLLKGTIKETL-RLYPVGI-TVQRYPVRDIVL-QN--YHVPA------G-----------TLVQVCLYP-LGRSAEVFSRPECFDPS------RW--SADADAG-----------SAGGFRSLAFGFG-----------SRQCVGRRIAE-NEMQLLLMHILRTFKLT----VSST---EELSTKYTL-----------ILQPEC----PPRI--T--F-----STLTH- Takifugu_rubripes_CYP11C1 ------EEIPH--------------TGRNSWVNL----------LRF-----WREDR---FRHLHKHMERTFN-----SLGPI--YREHVGTQSSVN-IMLPSDISELFRS--E----GLHPRRMTLQPWA-THRETRQHGKG---VFLKNGEE-WRADRLLLNKEVMMSEAVR--------RFIPLLDEVAQDFCHMMQTKVEREG------RGERGK-RSLTINPSPDLFRFALEASCHVLYGERIGL---FSSSP------SLESQ----KFIWAVERMLATTPPLLY---LPHRLLL-HLGAP---LWTQHASAW--DHIFTHAEERIQRGYQRLSHSQS----------------RGP---EGGGR-YKGVLGQL-------------------------------------------------MAKGQLSLELIKANITELMAGAVDTTAVPLQFALFELGRNPEVQQRVRQQVQES--W-A--------------------------------------------------------------QAG----------GDPQKA-LQEAPLLKGTIRETL-RLYPVGT-TVQRYPVKDIVL-QN--YHIPA------G-----------TMVQACLYP-LGRSAEVFEDPLRFDPG------RWGKSRE--EG--QRG------GGTGFRSLAFGFG-----------ARQCVGRRIAE-NEMQLLLMHILLGFDLS----VPSS---EDIKTMCTL-----------ILMPET----PPKI--T--F-----TKL--- Kryptolebias_marmoratus_CYP11C1v1 ------RGVDG----QVRRFEEIPHTGRNGWINL----------VKF-----WRENR---FQQLHKHMEGTFN-----ALGPI--YREKVGTLSSVN-ILMPSDISELFQS--E----GLHPRRMTLQPWA-THRETRNHSKG---LFLKNGEE-WRSDRLQLNKEVMLSAAVK--------RFLPLLDEVAKDFCRMLQMK---VEREGRGEEAKCSL----TIDPSPDLFRFALEASCHVIYGERIGL---FSSSP------SLESQ----KFIWAVERMLTTTPPLLY---LPPRLLL-RLGAP---LWTQHATAW--DHIFSHAEARIQRAYQRLMSSQS----------------RGS---ETGGQ-YTGVLGQL-------------------------------------------------MEKGQLSLDLIKANITELMAGGVDTTAVPLQFALFELGRNPEVQDMVRQQVRTS--W-A--------------------------------------------------------------QAG----------GDPQKA-LQGAPLLKATIKEVL-RLYPVGI-TVQRYPVKDIVL-QD--YHIPA------G-----------TMVQACLYP-MGRSALVFEDPLRFHPS------RWSSSRE--DG--RRG------EAGAFRSLAFGFG-----------ARQCVGRRIAE-NEMQLLLMNILLNFHLS----VPSS---EDLKTTVTL-----------ILQPET----PPKI--T--F-----SKL--- Oryzias_latipes_CYP11C1 ------EEIPH--------------TGRNGWINL----------LKF-----WRENR---FQQLHLHMERTFN-----ALGPI--YREKVGTLSSVN-ILLPADISEMFKS--E----GLHPRRMTLEPWA-THREIRNHRKG---VFLKNGEE-WRSDRLQLNKEVMMSAAVR-------R-FLPLLDDVAKDFCRLLEDRVEREGR--GAEEAKRSL----TIDPSPDLFRFALEASCHVLYGERIGL---FSSSP------SLESQ----KFIWAVERMLTTTPPLLY---LPPRLLL-RVGAP---LWTEHATAW--DHIFSHAEARIQRAYQRLSSSQG----------------SGTV--AAGGL-YGGVLGQL-------------------------------------------------MEKGKLSLDLIKANITELMAGGVDTTAVPLQFGLFELGRNPEVQDRVRQQVKRS--W-A--------------------------------------------------------------QAG----------GDPQKA-LQGAPLLKGTIKEIL-RLYPVGI-TVQRYPVHDIVL-QN--YHIPA------G-----------TMVQACLYP-MGRSSQVFEEPLNFDPG------RWSVSRE--KG--QRG------EVMGFRSLAFGFG-----------ARQCVGRRIAE-NEMQLLLMHILLRFHLS----VPSS---EDLQTTATL-----------ILQPKT----PPRI--T--F-----SKL--- Danio_rerio_CYP11A1 ------NKIPG--------------RWRNSLLSV----------LAF-----TKMGGLRNV--H-RIMVHNFK-----TFGPI--YREKVGIYDSVY-IIKPEDGAILFKA--E----GHHPNRINVDAWT-AYRDYRNQKYG---VLLKEGKA-WKTDRMILNKELLLPKLQG--------TFVPLLEEVGQDFVARVNKQ-----------IERSGQ-KQWTTDLTHDLFKFSLESVSAVLYGERLGLLLDNIDPE------FQHFI----DCVSVMFK---TTSPMLY---LPPGLLRSIGSNI----WKNHVEAW--DGIFNQADRYIQNIFKQWKENPEGNG-------------------KYPGV-----LAIL-------------------------------------------------LMQDKLSIEDIKASVTELMAGGVDSVTFTLLWTLYELARQPDLQDELRAEISAA--R-I--------------------------------------------------------------AFK----------GDMVQM-VKMIPLLKAALKETL-RLHPVAM-SLPRFITEDTVI-QN--YHIPA------G-----------TLVQLGVYA-MGRDHQFFPKPEQYCPS------RW--ISS---------------KRQYFKSLGFGFG-----------PRQCLGRRIAE-TEMQIFLIHMLENFRIE----KQKQ---IEVRSKFEL-----------LLMPEK----PIML--T--I-----KPLNA- Kryptolebias_marmoratus_CYP11A1 ------GEIPG--------------LWKNGVVNL----------YNF-----WKLDG---FRNLHRIMLQNFN-----TFGPI--YREKIGYYESVN-IIKPEDAAILFKA--E----GHYPKRLKVEAWT-SYRDYRNRKYG---VLLKNGED-WRSNRVILNKEVISLKMLE--------NFVPLLDEVGQDFVARVHKK-----------IKRSGQ-NKWTTDLSQELFKYALESVSSVLYGERLGLMLDYIDPE------AQRFI--------DCITLMFKTTSPML--YVPPALLRQIGSKV----WRDHVEAW--DGIFNQADRCIQNIYRQLRQETG--------------PSK-----KYPGV-----LATL-------------------------------------------------LLLDKLSIEDIKASVTELMAGGVDTTSITLLWTLYELARHPNLQEELRAEVAAA--R-A--------------------------------------------------------------ASQ----------GDMLEM-LKRIPLVKGALKETL-RLHPVAV-SLQRYITEDIII-QN--YHIPS------G-----------TLVQLGLYA-MGRDPKVFLRPEQYQPS------RW--LRT---------------ETHYFRSLGFGFG-----------PRQCLGRRIAE-AEMQLFLIHMLENFQVE----KQRS---VEAQSTFEL-----------ILVPDK----PIIL--T--L-----KPLQA- Oryzias_latipes_CYP11A2 ------GSIPGEQQRCAGLSMRFPDRWKNGLVNL----------YNF-----WKLDG---FKNLHRIMVQNFN-----TFGPI--YREKIGYYESVN-IIKPEDAATLFKA--E----GHYPKRLKVEPWT-SYRDYRNRKYG---VLLKNGAD-WRSNRVILNKEVIFLKMLE--------NFVPLLDDVGQDFVARVHKK-----------IKRNGQ-NKWTTDLSQELFKYALESVGSVLYGERLGLLLDYIDPE------AQHFI--------DCITLMFKTTSPML--YIPPSVLRRIGSKV----WRDHVDAW--DGIFNQADRCIQNIYRELRLET-----------------------GTSEK-YPGVLASL-------------------------------------------------LMLDKLSIEDIKASITELMAGGVDTTSITLLWTLYELARHPSLQEELRLEVAAA--R-A--------------------------------------------------------------RSQ----------GDMMEM-LKRVPLIKGAIKETL-RLHPVAV-SLQRYITEDIVI-QN--YHIPA------G-----------TLVQLGLYA-MGRDPKVFFRPEQYQPS------RW--LRT--ET-----------H--YFRSLGFGFG-----------PPQCLGRRIAE-TEMQIFLIHMLENFRVE----KQRH---IEVQSTFEL-----------ILLTDK----PIIL--T--L-----KPLQA- Danio_rerio_CYP24A1 ------DSIPG------------P-TNWPLFGSL----------IEV-----IRNGGLKRQ--H-ETLIHFHK-----KFGKI--FRMKLGSFESVH-IGSPCLLEALYRK--E----GSYPERLEIKPWK-AYRDMRDEAYG---LLILEGRD-WQRVRSAFQQKLMKPTEVM--------KLDGKINEVAADLIKRIGKV-----------NGKMDA-------LYFELNKWSFETICYVIYDKRFGL---LQDSV------SKEGM----DFITAVKTMMSTFGTMMV--TPVELHKT-LNTKT----WKDHTEAW--DRIFSTAKHYIDKNLQKQSNGEA-------------------------DD-F---LSDI-------------------------------------------------FHNGNLTKKELYAATTELQVGGVETTANSMLWVIFNLSRNPCAQGKLLKEIQDV--V-P--------------------------------------------------------------AGQ----------TPRAEH-IKSMPYLKACLKESM-RVSPSVPFT-SRTLDKDTVL-GD--YTLPK------G-----------TVLMLNSQA-IGVSEEYFDNGRQFRPE------RW--LEE--KS--SIN---------PFAHVPFGVG-----------KRMCIGRRLAE-LQIQLGLCWILRDYKIV----ATDL---EPVDSLHSG-----------TLVPSR----ELPV--A--F-----VPR--- Kryptolebias_marmoratus_CYP24A1 ------DSMPG------------P-TNWPLVGSL----------VEL-----LRKGG---LTRQHEALVDYHK-----KFGKI--FRMKLGSFESVH-IGAPCLLEALYRK--E----SNYPQRLEIKPWK-AYRDLRNEAYG---LLILEGKD-WQRVRSAFQQKLMKPTEVV--------KLDGKINQVLVDMVDRIGKV-----------NVDGKI-----DDLYFELNKWSFETICLVLYGKRFG----LLQEK------VNEEA----MSFITAVKTMMSTFGMMM---VTPVELHKRFNTK---TWQDHTAAW--DRIFSTAKVYIDKKLKRNAIRDP----------------D-----DLIGE-----ILHQ----------------------------------------------------SSLSKKELYAAITELQIGGVETTANSMLWVIFNLSRNPGAQKKLLQEIREV--V-P--------------------------------------------------------------SGQ----------NPCGEH-IKNMPYLKACLKESM-RLSPSVPFT-SRTLDKDTVL-GD--YTIPK------G-----------TVLMINSHA-LGSNEEYFDDGKHFRPE------RW--LRE--NS--TIN---------PFAHVPFGIG-----------KRMCIGRRLAE-LQLQLAMCWLVRDYEIV----ATDN---EPLDVIHSG-----------LLVPSR----ELPV--A--F-----IRR--- Danio_rerio_CYP27C1 ------KEMPG------------P----STVANL----------LEF-----FYRDG---FSRIHEIQMEHAK-----KYGKI--FKSRFGPQFVVS-IADRDMVAQVLRS--E----SATPQRGNMESWK-EYRDLRGRSTG---LISAEGDE-WLKMRSVLRQLIMRPRDVA--------VFSSDVNDVVADLVKRVKTL-----------RSQQDD-SQTVLNINDLFFKYAMEGVATILYETRLG----CLENE------IPKMS---QEYITALHLMFSSFKTTMYAGAIPKWLRP-IIPKP----WEEFCSSW--DGLFKFSQIHVDKRLSEIKKQME----------------KSE---EIKGG-L---LTHM-------------------------------------------------LVTREMNLEEIYANMTEMLLAGVDTTSFTLSWSTYLLARHPTIQQQIFEEVDRV--L-G---------------------------------------------------------------GR----------VPTGED-VPYLPLIRGLVKETL-RLFPVLP-GNGRVTHDDLIV-GG--YLIPK------G-----------TQLALCHYS-TSMDEENFPRPEEFRPD------RW--IRK--DASDRVD---------NFGSIPFGYG-----------IRSCIGRRIAE-LEMHLALTQLLQNFHIE----VSPQ--TTEVHAKTHG-----------LLCPGA----SINL--R--F-----TDRK-- Takifugu_rubripes_CYP27C1 ------AEMPG------------P----GTISNL----------FEF-----FWRDG---FSRIHEIQIEHSK-----MYGKI--FKSRFGPQLVVS-VADRDLVAEVLRA--E----GVAPQRANMESWH-EYRDMRRRSTG---LISAEGED-WLRMRSVLRQLIMRPRDVA--------VFSDDVSEVVDDLIKRIVCL-----------RSQSSD-GTTICNINDLFFKYAMEGIAAILYECRLG----CLSQK------IPQET---EDYIDALHLMFSSFKTTMYAGAIPKWLRP-VFPKP----WEEFCDSW--DGLFRFSCVHVDKRLKQIESQLQ----------------RGE---KVTGG-L---LTYM-------------------------------------------------LVAKEMSVEEIYANVTEMLLAGVDTTSFTLSWASYLLARHPDVQQQIHAEVMRV--L-G--------------------------------------------------------------SEK----------VATAED-VQHLPFIRGLVKETL-RLFPVLP-GNGRITQDDMVL-GG--YFIPK------G-----------TQLALCHYS-TSLDDENFPSSLEFRPD------RW--IRK--HSSDRLD---------NFGSIPFGYG-----------IRSCIGKRIAE-LEMHLALIRIIQKFHVC----VSPL--TTDVKAKTHG-----------LLCPGA----PINL--Q--F-----IDREI- Kryptolebias_marmoratus_CYP27C1 ------KEMPG------------P----GTLSNL----------IEF-----FWRDG---FSRIHEIQMEHRQ-----KYGKI--FKSHFGPQLVVS-IADRDLVAEVLRA--E----GVAPQRANMESWK-EYRNMRGRSTG---LISAEGED-WLRMRSMLRQLIMRPRDVA--------VFSDDVNQVVDDLIRRVSAL-----------RAQQPD-GATVTNVNDLFFKYAMEGVAAILFECRLG----CLEND------IPKET---QDYISALNLMFSSFKTTMYAGAIPKWLRP-VIPKP----WEEFCHSW--DGLFRFSVLHVDKRFAEVASRLQ----------------RGE---EVRGG-L---LTHM-------------------------------------------------LTRMEMSLEEIYANVTEMLLAGVDTTSFTLTWASYLLARHPRIQQQIYTEVTQT--L-G--------------------------------------------------------------PGA----------VPTADD-VPRLPLIRGLVKETLSRLFPVLP-GNGRITQDDLVV-GG--YFIPK------G-----------TQLALCHYS-TSMDEENFANAVDFQPD------RW--VRK--DSTDRVD---------NFGSIPFGYG-----------IRSCIGRRIAE-LEMHLALTRLIQRFHIG----ASPL--TAEVKAKTHG-----------LLCPAA----PVHL--Q--F-----IQREN- Oryzias_latipes_CYP27C1 ------NDMPG------------P----STLSNL----------VEF-----FWRDG---FSRIHEIQLEHRK-----KYGKI--FKSRFGPQLVVS-IADRGLVAEVLRA--E----GVAPQRANMESWQ-EYRDMRGRSNG---LISAEGED-WLNMRSVLRQLIMRPKDVA--------VFSDDVNKVVDDLVKRVCTL-----------RAQESD-GATVFNVNDLFFKYAMEGVASILYECRLG----CLENN------VPQKT---QDYIGALNLMFSSFKTTMYAGAIPKWLRP-IIPKP----WEEFCSSW--DGLFKFSMIHVDKRFNDIKAQLE----------------RGE---EVKGG-L---LTHL-------------------------------------------------LVTKEMSIEEIYANVTEMLLAGVDTTSFTLSWATYMLAQHPDIQEQIHGEITRT--L-G--------------------------------------------------------------PGT----------VPTAED-VSQLPLIRGLVKETL-RLFPVLP-GNGRIIQDDLVV-GG--YFIPK------G-----------TQLALCHYS-TSLEEENFPGALEFQPQ------RW--VRK--DA-SDRV------D--NFGSIPFGYG-----------IRSCVGRRIAE-LELHLALIRLIQKFRIE----VSPV--TTEVKAKTHG-----------LLCPSA----PINL--R--F-----VDREN- Danio_rerio_CYP27B1 ------EQMPG------------P-SPARFIRDL---------FMKR-----GFSRL------H-QLQLEGRQ-----KYGPM--WKASFGPILTVH-VAEPELIQQVLRQ--E----GQHPVRSELSSWK-DYRALRGEGYG---LLTAEGEE-WQCVRSLLSKHMLRPQAVE--------AYDGALNAVVSDLLQKLKLR-----------SQESSS--RIVSDISAEFYRFGLEGISSVLFESRIG----CLDAV------VPVET----ERFIQSINTMFVMTLLTM--AMPQWLHR-LLPKP----WDTFCRCW--DVMFEFAKGHIDQRLQEEKQKLE---------CG-----------EQLEGRY---LTYF-------------------------------------------------LSQAGLPLTSVYSNVTELLLAGVDTISSTLSWSLYELSRHPDVQTALRDEVLSV--M----------------------------------------------------------------KDR---------SVPQASD-VAAMPLLKAVVKEIL-RLYPVIP-ANARVINKDIEV-GG--YVIPK------N-----------TLITLCHYA-TSRDPQQFRDPDSFRPQ------RW--GDR--SD-----------RSHPYATVPFGVG-----------KRSCIGRRIAE-LEVYLALSRILMHFTME----PVRE--NDTVHPMTRT-----------LLVPER----QIDL--R--F-----TER--- Kryptolebias_marmoratus_CYP27B1 ------DHMPG------------P-GVASFAWDL---------FAKK-----GLSRL------HELQMAGLR------RYGPM--WKASFGPILTVH-VAKPELIEQVLRQ--E----GQHPMRSNLSSWK-DYRKLRGHHCG---LLTSEGEE-WQEVRSLLGKHMLRPKAVE--------VYDKTLNSVVDDLIAKLRHR-----------RSSQGL----VTDIASDFYRFGLEGISSVLFESRIG----CLDPV------VPKET----ERFIQSINTMFVMTLITM--ALPSWLYQ-LCPKP----WNDFYRSW--DYMFDFAKSHIDQRMAADAKKVA----------------RGE---SVEGH-Y---LTYF-------------------------------------------------LSQTNLPMKTVYSNITELLLAGVDTISSTLSWTLYELSRHPEVQAEIRKEVLTV--L-G--------------------------------------------------------------GRR----------IPEATE-VANMRLLKAAVKEVL-RLYPVIPANARVVPEKDIQV-GG--YIIPK------N-----------TLITLCHFA-TSRDPSVFPNPNDFHPY------RW--FSK--DQ-----------THHPYASVPFGVG-----------KRSCIGRRIAE-LELYLALSRILTEFDVQ----PDPK--GVSVKPMTRT-----------LLVPKN----VINL--Q--F-----IER--- Danio_rerio_CYP27A3 ------DDLDG------------P----SFLTSL----------YWL-----FGKGY---FQTTHQMQIEHSK-----IYGPL--WKSKYGPLVIVN-VASADLIEQVLRQ--E----GRHPIRTDMPHWR-GYRKLRNHAYG---PLTEMGPE-WQRIRSILNPRMLKPKHVS--------NYTNAINGVVSDFIEKMAKL-----------KTTKGN-DVMVYDVAGELYKFAFEGISSVLFETRMG----CLNDE------IPEET----QKFIFSVGEMFRLSPIVI--LFPKFLWP-YMPF-----WKHFVAVW--DHLFKVADELVQQKMTEIQEKVK------------TG--------SPVEGEY---LTHL-------------------------------------------------LISEQMSFTEVLGSITELLLAGVDTTSNTISWALYHLAREPEIQQKLHEEVVSV--CPG---------------------------------------------------------------DK----------TPSSDD-ITRMPLLKAIVRETL-RLYPVVPGNARVVAENEIVV-GD--HLFPK------N-----------TLFHLCHFA-VSYDETVFPDPFAFLPQ------RW--IRE--QKQLSQH---------PFGSVPFGFG-----------IRACLGRRVAE-LEMYLLLSRLIKRYEVR----PDPS--GKTVKPITRT-----------LLVPAT----SIDL--Q--F-----IDR--- Kryptolebias_marmoratus_CYP27A3 -----------------------------SLGSV---------GLRL-----DRRRH----EGLLRAAIEHKK-----IYGPL--WKSKYGPLVVVN-VASAELIEQVLRQ--E----GRHPVRTDMPHWR-GYRELRNQAHG---PLTEMGAK-WQRIRSILNPRMLKPKHVS--------SYSDTINNVVTDFIRRVAWL-----------RDTGGQ-GTVVNDVTDELYKFAFEEYSQYLENTRMGCMNEVVPEE------TEKFI----FSVGEMFRLSPIVVLFPK--SLWPYLPF----------WKQFVSTW--DHLFKKAERLVNKKMEEIQQSVD--------------LDR-----NVEGA-Y---LTHL-------------------------------------------------LLSDQMSVTEILGSVTELLLAGVDTTSNTISWSLYHLAKEPEIQEQLYQEVVSV--CPG---------------------------------------------------------------DK----------VPNSDD-ISHMPYLKAVIKETL-RLYPVVPGNARVTVENEIVV-GD--CLFPK------Q-----------TLFHLCHYA-VSYDENIFPDSHTFLPQ------RW--LRG--GD--DKF------RQHPFGSVPFGFG-----------IRACLGRRVAE-LEMYLLLSRLIKHYEVK----PDPA--GTVVKPITRT-----------LLCPAT----PINL--Q--F-----LDRRA- Danio_rerio_CYP27A7 ------ADLPE----------------IKIFTML----------YRL-----LFKGY---LSRMHELQLYEKQ-----LYGPL--YKINVGNFQSVA-LNSVDLLEELLRK--D----EKFPSRGDMTLWT-EYRDMKGIGYG---PFTEEGEK-WYKLRAVLNKRMLHPKDSV--------QYGDVVNAVITDFIKRIYYL------------REMSPTGDLVSNLTNELYRFSLEGISSILFETRIG----CLEKE------IPAET----QHFINSIAQMLTYSMPVV--FMPNWTRN-YLPF-----WQRYIGGW--DGIFKFAGKMIDMKMEALQKRVD--------------ANQ-----EVAGE-Y---LTYL-------------------------------------------------LSNGKMSSKDVYGSVSELLLAGVDTTSNTMLFALYHLSKDPETQDILYQEVTNV--L-K--------------------------------------------------------------DDR----------IPTAQE-VNTMSYLKAVIKETL-RLYPVVPMNARLIAENEVVI-GG--HLFPK------N-----------TTFTLCHYA-ISRDEKVFPEPQKFKPE------RW--LRD------GRT------RPNPFGSIPFGFG-----------VRGCVGRRIAE-LEMYLALARLIKLFEIR----PDPT--VGEVRSLNRT-----------VLAPDR----KVNL--H--F-----VERKK- Danio_rerio_CYP27A1.4 ------TEADL--------------PEIKIFTML----------YQM-----LFKGY---LNSVHELQLYQKQ-----VYGPL--WKINAGNLQGIS-ITSVELLEELLRK--D----EKYPCRGYMTLWT-EHRDLRGISYG---PFTEEGEK-WYKLRAVLNKRMLHPKDSL--------QYGDVVNAVITDFIKRIYYL-----------REMSPT-GDLVSNLTNELYRFSLEGIASILFETRIG----CLEKE------IPAET----QEFINSIAQMFTYNMHVA--LLPNWTRN-YLPF-----WQKYIDGW--DGIFKFGTKMINLKMEAIQTRLD--------------TNQ-----EVAGE-Y---LTYL-------------------------------------------------LSSGKMSCKDVYGSVSEVLLAGVDTTSNTMLWALYLLSKDPAAQETLHQEVTKV--LKG---------------------------------------------------------------DR----------IPTAEE-VNSMPFLKAVIKETL-RLYPVVPVNSRLIAESEVII-GE--YLFPK------K-----------TTFNLFHYA-ISHDEKVFPEPQKFKPE------RW--LRD------GRT------RPNPFGSIPFGFG-----------VRACVGRRIAE-LEMHLALARLIKLFEMR----PDPT--VGEVKANFRS-----------VLVPNK----KVNL--H--F-----VERQK- Danio_rerio_CYP27A5 ------AERLG-------------------LGFL----------RPM-----AAATG----------------------------FRSAAGNAAAAS-VSVQDGHRKLKTE----------ADLPEIKIFT---------------MLYQM--L----FKGYLNSMLHPKDSVQ---------YGDVVNAVITDFIKRIYYL------------REMSPTGDLVSNLTNELYRFSLEGIASILFETRIG----CLEKE------IPVET----QEFINSIAQMFTYSMHVA--LLPNWTRN-YFPF-----WQKYIDGW--DGIFKFGTKMIDMKMEAIQKRVD--------------TNQ-----EVAGE-Y---LTYL-------------------------------------------------LSSGKMTSKDVYGSVSELLLAGVDTTSNTMLWALYLLSKDPAAQETLYQEVTKV--L-K--------------------------------------------------------------DDR----------IPTAEE-VNSMPFLKAVIKETL-RLYPVVPVNSRLIAETEVVI-GE--YFFPK------K-----------TTFNLCHYA-ISHDEKVFPEPQKFKPE------RW--LRD------GRT------RPNPFGSIPFGFG-----------VRACVGRRIAE-LEMHLALARLIKLFEMR----PDPT--VGEVKANFRS-----------VLVPNK----KVNL--H--F-----VERQK- Danio_rerio_CYP27A6 ------AERLG----------------WCFLRPT-------------------------------AAATGFRS-----AAGNA-------AAASVSV-QDGHRKLKTE-------------ADLPEIKIFT---------------MLY--QML----FKGYLNSMLHPKDSVQ---------YGDVVNAVITDFIKRIYYL------------REMSPTGDLVSNLTNELYRFSLEGIASILFETRIG----CLEKE------IPAET----QKFINFIAQMFTYSMHVA--LLPNWTRK-YFPF-----WQKYIDGW--DGIFKFGTKMIDMKMEAIQKRVD--------------TNQ-----DVAGE-Y---LTYL-------------------------------------------------LSNGKISRKDVYGSVSELLLAGVDSTSNTMLWALYLLSKDPEAQETLYQEVTKV--L-K--------------------------------------------------------------DDR----------IPTAEE-VNSMPFLKAVIKETL-RLYPVVPVNSRLIAETEVVI-GE--YFFPK------K-----------TTFTLCHYV-ISRDEKVFPEPQKFKPE------RW--LRD--GR-TRPN---------PFGSIPFGFG-----------VRACVGRRIAE-LEMHLALARLIKLFEMR----PDPT--VGEVKANFRS-----------VLVPNK----KVNL--H--F-----VERQK- Kryptolebias_marmoratus_CYP27A1 ------TAEDL--------------PRVRFLELL----------YRM-----VFQGF---YNRLHELQIYEKQ-----LYGPI-----YNSGLKSVS-VNTPQLLEELLRK--D----EKFPSRGDMSLWT-EYRDMRGLGYG---PFTEEGKQ-WYNLRVVLNKRMLHPKDSA--------QYAGVINEVVTDFIRRIEYL------------RRRSPTGDLVSDISNELYLFSLESIASVLFETRLG----CLEKE------IPAGT----QEFIDSIAQMFSYSMVVV--ILPKWSRR-LLPY-----WGRYIAGW--EGIFTFAKMLIDKKMEDIQQRVD----------------RNQ---DVQGE-Y---LTYI-------------------------------------------------LSNTQMSAKDVYGSITELLLAGVDTTSNTLTWALYQLSKNPQVQDRLYEEVSSV--V-P--------------------------------------------------------------ADR----------IPTAAE-VTQMPYLRAVIKETL-RMYPVVPLNARIMTEKNISV-GG--YQFPK------K-----------TTFTFCHYA-ISHDESVFPQSFTFRPE------RW--LR---DG-HQRP------N--PFGSIPFGYG-----------VRGCVGRRVAE-LEMYLVLFQLIRQFEVK----PDPR--TGELKSISRT-----------VLVPDK----QLNL--H--F-----VDRGR- Oryzias_latipes_CYP27A1 ------RTIDD-----------LP--RVSLLEML----------YRL-----VFQGFYNRM--H-ELQLYEKQ-----RYGPI-----YLNGLKAVS-VNTAKLLEELMRK--D----EKFPCRGDMTLWT-EFRDIRGLGYG---PFTEEGKK-WYDLRTVLNKRMLSPKDSA---Q-----YDGVFNAVVTDFIKRINFLRQGSP------TGDLVP------NIGNELYLFSLEGIASILFETRLG----CLEKE------IPPGT----QEFINSISAMFSNSMAVV--LIPKWGRN-ILPY-----WRRYIAGW--DGIFSFAKKLIDKKMETIKQRVD--------------NNQ-----EVEGE-Y---LTYL-------------------------------------------------LSNTQMSTKDVYASIAELLLAGVDTTSNTLTWALYQLSKEPEVQERLYKEVSTS--V-P--------------------------------------------------------------ADR----------LPTAAE-VTRMQYLRAVIKETL-RMYPVVPVNARIVTERGITV-GG--YQFPK------N-----------TPFNFCHYA-ISHDEEIFPESFKFKPE------RW--LRD---G-RERP------N--PFGSVPFGYG-----------VRGCVGRRIAE-LEMYLLLFQLIRHFEIK----PDPA--VGELKSINRT-----------VLVPDK----PLSL--H--F-----VNRG-- Danio_rerio_CYP26A1 ------PLPPG------------T-MGLPFIGET----------LQL-----ILQRR--------KFLRMKRQ-----KYGCI--YKTHLFGNPTVR-VMGADNVRQILLG--E----HKLVSVQWPASVR-TI-------LGSDTLSNVHGVQ-HKNKKKAIMRAFSRDALEH---------YIPVIQQEVKSAIQEWLQK-----------DSC--------VLVYPEMKKLMFRIAMRILLGFEPE----QIKTD------EQELV----EAFEEMIKNLFSLPIDVP----FSGLYR-GLRAR--------------NFIHSKIEENIRKKIQDDDNENE----------------Q-----KYKDA-L-QLLIEN-----------------------------------------------SRRSDEPFSLQAMKEAATELLFGGHETTASTATSLVMFLGLNTEVVQKVREEVQEKVEM-G-----------------------------------------------------------MYTPGK----------GLSMEL-LDQLKYTGCVIKETL-RINPPVP-GGFRVALKTFEL-NG--YQIPK------G-----------WNVIYSICD-THDVADVFPNKDEFQPE------RF--MSK------GLE------DGSRFNYIPFGGG-----------SRMCVGKEFAK-VLLKIFLVELTQHCNWI----LSNG----PPTMKTGP-----------TVYPVD--NLPTKF--T--S-----YVRN-- Takifugu_rubripes_CYP26A1 ------PLPPG------------T-MGLPFIGET----------LQL-----ILQRR--------KFLRMKRQ-----KYGYI--YRTHLFGNPTVR-VTGANNVRHILLG--E----HRLVAVQWPASVR-TI-------LGSDTLSNVHGAQ-HKTKKKAIMQAFSREALEF---------YIPAMQHEVQAAVQEWLAK-----------DSC--------VLVYPEMKRLMFRIAMQILLGFQLE----QIKTD------EQKLV----EAFEEMIKNLFSLPIDMP----FSGLYR-GLKAR--------------NFIHAKIEENIKRKLRESNSDSK---------------CR-----DALQQ-L---IDSS-----------------------------------------------K-KSGQVLSMQVLKESATELLFGGHETTASTATSLIMFLGLNPEVLDKLRHELSDKERQ-G-------------------------------------------------------------VDLR----------SLNLET-LEQLKYTSCVIKETL-RMNPPVP-GGFRVALKTFEL-GG--YQIPK------G-----------WNVIYSICD-THDVAEIFPNKEDFQPE------RF-MMKN--CG-----------DSSRFQYIPFGGG-----------SRMCVGKEFAK-VLLKIFLVEVVTKCHWS----LLNG----PPTMKTGP-----------TVYPVD--NLPTKF-NT--Y-----VQN--- Kryptolebias_marmoratus_CYP26A1 ------PLPPG------------S-MGFPFLGET----------LQL-----ILQRR--------KFLRMKRQ-----RYGFI--YRTHLFGTPTVR-VTGADNVRRLLLG--E----HRLVSAQWPTSVR-TI-------LGPDTLSNLHGSQ-HKTKKRAIMRAFSRESLEL---------YIPEIQEEVRAAVTEWTVK-----------DSC--------VLVYPEMKRLMFRIAMRILLGFKPE----QIRID------EQQLV----EAFEEMIRNLFSLPIDVP----FSGLYR-GLKAR--------------NFIHSKIEENIKKKVLESEQGLK---------------HR-----DALQQ-L---IDSS-----------------------------------------------R-KNNEPFSMQAIKESATELLFGGHETTASTATSLVMFLGLNPEVVDKLRQELLEKEEQ-G-------------------------------------------------------------MDLQ----------SLNLES-LEQLKYAGCVIKETL-RMNPPVP-GGFRVALKTFQL-NG--YQIPK------G-----------WNVIYSICD-THDVAEIFPNKEDFQPQ------RF--ITK------PSA------DSSRFQYIPFGGG-----------SRMCVGKEFAK-VLLKIFLVEVVTKCHWT----LLNG----PPTMKTGP-----------TVYPVD----NLPT--K--F-----TSYSQ- Oryzias_latipes_CYP26A1 ------PLPPG------------S-MGLPFIGET----------LQL-----LLQRR--------KFLRMKRQ-----KYGYI--YRTHLFGSPTVR-VTGADNVRQILLG--E----HRLVSAQWPASVR-TI-------LGSDTLSNMHGSQ-HRTKKKAIMRAFSREALEL---------YIPVIQEEVQAAVKSWLAR-----------DSC--------VLVYPEMKRLMFRIAMRILLGFEPE----QIRTD------EQQLV----EAFEEMIKNLFSLPIDVP----FSGLYR-GLRAR--------------NFIHSKIEENIKNKVQESEKGSK---------------HR-----DALQQ-L---IDSS-----------------------------------------------K-KSGEPFRMQGIKESATELLFGGHETTASTATSLVMFLGLNPGAVDRLRQELRDKVEL-G-------------------------------------------------------------MDLQ----------NLNMES-LERLKYAGCAIKETL-RINPPVP-GGFRVALRTFQL-NG--FQIPK------G-----------WNVIYSICD-THDVADIFPNKEDFRPE------RF--MDK------SFV------DSSRFQYIPFGGG-----------SRMCVGKEFAK-VLLKIVLVELVSRCHWT----LLNG----PPTMKTGP-----------TVYPVD--NLPTKF--T-SY-----LPK--- Danio_rerio_CYP26B1 ------PMPKG------------S-MGFPIIGET----------CHW-----FFQGA--------GFHASRRQ-----KYGNV--FKTHLLGRPLIR-VTGAENVRKVLMG--E----HSLVTVDWPQSTS-TL-------LGPNSLANSIGDI-HRKRRKIFAKVFSHEALES---------YLPKIQQVIQETLRVWSSN-----------PDP--------INVYRESQRLSFNMAVRVLLGFRIP------EEE------MHCLF----STFQEFVENVFSLPIDLP----FSGYRK-GIRAR--------------DSLQKSIEKAIREKPLHTQGKDY----------------T-----DALDV-L---LESA-----------------------------------------------K-ENNTELTMQELKESTIELIFAAFATTASASTSLVMQLLRHPAVLEKLREELRSC----G-------LLHDG-------------------------------CL----------------C-QG----------ELRLDS-IISLKYLDCVIKEVL-RLFAPVS-GGYRIATQTFEL-DG--VQVPK------G-----------WSVMYSIRD-THDTSAVFKDVEAFDPD------RF--SPE--RS-EDRE------G--RFHYLPFGGG-----------VRSCLGKQLAT-LFLKLLAVELAGGSRFE----LSTR---TFPRMISVP-----------VVHPTD----GLRV--K--FFGLDSNQNQI- Kryptolebias_marmoratus_CYP26B1 ------PMPRG------------S-MGFPFIGET----------CHW-----LLQGS--------SFHASRRQ-----KYGNV--FKTHLLGRPLIR-VTGAENIRKVLMG--E----HTLVTVDWPQSTS-TL-------LGPNSLANSIGDI-HRKRRKVFAKVFSHEALES---------YLPKIQQVIQESLRVWSSN-----------PEP--------INVYRESQRLSFTMAVRVLLGFRIS------EEE------MRHLF----STFQDFVNNLFSLPIDLP----FSGFRK-GIRAR--------------DVLQKSVEKAIREKPLCSQGKDY----------------S-----DALDV-L---MESA-----------------------------------------------K-ENGTELTMQELKESTIELIFAAFATTASASTSLIMALLRYPHVLERLREELRAR----G-------LLHNG-------------------------------CL----------------CPEG----------ELRLDT-IISLKYLDCVIKEVL-RLYTPVS-GAYRTAMQTFEL-DG--VQIPK------G-----------WSVMYSIRD-THDTAAVFKDVEAFDPD------RF--SQE--RS-EDKE------G--RFHYLPFGGG-----------VRSCLGKQLAT-LFLRLLAIELASTSRFE----LATR---QFPRIITVP-----------VVHPVD----GLKV--K--FYGLDSNQNEI- Oryzias_latipes_CYP26B1 ------PMPKG------------S-MGFPFIGET----------CHW-----LLQGS--------NFHASRRQ-----KYGNV--FKTHLLGRPLIR-VTGAENVRKVLMG--E----HTLVTVDWPQSTS-TL-------LGPNSLANSIGDI-HRKRRKVFAKVFSHEALTM---------YLPKIQQVIQESLRVWSSN-----------PDP--------INVYRESQKLSFTMAVRVLLGFRVS------EEE------MKHMF----SAFQDFINNLFSLPIDLP----FSGFRK-GIRAR--------------DILQKSIEKAIREKPMCSQGKDY----------------S-----DALDV-L---MESA-----------------------------------------------K-ENGTELTMQELKESTIELIFAAFATTASASTSLIMQLLQHPTVLERLREELRSK----G-------LLHNG-------------------------------CL----------------CPEG----------ELRLET-IVSLKYLDCVIKEVL-RLFTPVS-GAYRTAMQTFEL-DG--VQIPK------G-----------WSVMYSIRD-THDTAAVFKDAEVFDPD------RF--SPE--RG-EDKE------G--RFHYLPFGGG-----------VRSCLGKQLAT-LFLRLLAIELASTSRFE----LATR---QFPRLTTVP-----------VVHPVD----GLKV--K--FYGLDSNQNEI- Danio_rerio_CYP26C1 ------PLPQG------------S-MGWPLVGET----------FHW-----LFQGS--------SFHISRRE-----KHGKV--FKTHLLGKPLIR-VTGAENIRKILLG--E----HTVVCTQWPQSTR-II-------LGPNTLVNSVGDL-HKRKRKVLAKVFSRGALEA---------YLTRLQDVVKSEIAKWCTE-----------TGS--------VEVYTAAKSLTFRIAVRVLLGLHLE------EQQ------ITYLS----KTFEQLMNNLFSLPIDTP----VSGLRK-GIRAR--------------EILHSAMEKIIEEKLKKQQAS------------------------DYCDA-FDYMLSSA-----------------------------------------------R-ENDYELTMQELKETAVELIFAAHSTTASASTSLIMQLLRHPDVSERARAELESE----G-------LITDGHGHCRSRCNGNAISEEGEAAEKSTSDRRSAINKATYFEAGDKEEGRRSRTHVP----------YLSLEK-LSQLSYLDCVVKEVL-RFLPPVS-GGYRTVLQTFEL-NG--YQIPK------G-----------WSVMYSIRD-THETAEAYQNPELFDPD------RF--CVG--RE-ESKS------E--RFSYVPFGGG-----------VRRCIGRELAL-IVLKTLAVELLATADCT----LATQ---TYPRMQTVP-----------IVHPVN----GLHV--F--F-----NYRTQ- Takifugu_rubripes_CYP26C1 ------PLPKG------------S-MGWPLVGET----------FQW-----LFQGS--------NFHISRRK-----RHGNV--FKTHLLGKPLVR-VTGAENIRKILLG--E----HSLVCTQWPQSTR-II-------LGPNALVNSIGEL-HKRKRKILAKVFSRKALES---------YLPRLQEVIKCEIAKWCAE-----------PGS--------VDVYAATRSLTFRIAIGVLLGLHLE------EER------IDYLA----QIFGQLMSNLFSLPIDAP----FSGLRK-GIKAR--------------KILHANMEKIIEKKMERQQEEE-----------------------EYRDA-FDYMLSTS-----------------------------------------------K-EQGQQISIQELKETAVELIFAAHSTTASAATSLVLQLLHHPEVVERVRVELEAQ----K-------L---CYNSLNLPSQAC-----GQKKDQST-------NLLR-------GTFPQSQCHAS----------NLSLDK-LNQLHYIDCVIKEVL-RFLPPVS-GGYRTALQTFEL-DG--YQIPK------G-----------WTVMYSIRD-THETAEIFQNPELFDPD------RF--VTA--QV-ESRS------S--RFSYVPFGGG-----------VRSCVGKELAQ-IILKTLTIELIRTCKWT----LATE---KFPKMQTVP-----------IVHPVN----GLHV--N--F-----MYKNL- Kryptolebias_marmoratus_CYP26C1 ------PLPNG------------S-MGWPLVGET----------FHW-----LFQGS--------NFHISRRE-----RHGNV--FKTHLLGKPVIR-VTGAENIRKILLG--E----HSLVCTQWPQSTR-II-------LGPNTLVNSVGDL-HKKKRKILAKVFSRGALES---------YLPRLQDVIKSEVAKWCSE-----------PGA--------IDVYSSAKSLTFRIAVSVLLDLQLE------EER------IHYLA----KIFEQLMNNLFSLPIDAP----LSGLRK-GIKAR--------------EILHANMEKIIEEKMARQQVED-----------------------EYQDA-FDYMLSSA-----------------------------------------------K-EHSQQLSIQELKETAVELIFAAHSTTASASTSLILQLLCHPAVVEKARVELDAE----G---------------------------LGYQQNQSHNSSCVTVEKEQDDAETTHLLNSYGQNAGDEFPRSKSHIPYLTLDK-LSQLQYIDCIVKEVL-RFLPPVS-GGYRTALQTFEL-DG--YQIPK------G-----------WSVMYSIRD-THETAPVFQSPELFDPD------RF--GPE--RD-ESRS------S--RFSYVPFGGG-----------VRRCVGKELAQ-IILKTLAVELIGTCKWT----LAME---NFPKMQTVP-----------IVHPVN----GLHV--R--F-----SCNSL- Oryzias_latipes_CYP26C1 ------PLPRG------------S-MGWPLVGET----------FHW-----LFQGS--------NFHISRRE-----RHGNV--FKTHLLGKPLIR-VTGAENIRKILLG--E----HNLVCTQWPQSTR-II-------LGPNTLVNSIGDL-HRRKRKVLAKVFSRGALES---------YLPRLQDTIKSEIAKWCSE-----------PGS--------IDVYSAAKSLTFRIAVAVLLGLQLE------EER------IVYLA----KIFEQLMNNLFSLPIDAP----FSGLRK-GIKAR--------------EILHANMEKIIEEKMQRQQTEEE---------------HQ-----DFFDF-M---MSSA-----------------------------------------------K-EQDHELSIQELKETAVELIFAAHSTTASASTSLVLQLLRHPEVVEKAGVELEAE--GLDFDSNRSQIPLGVMAETAQDAFETTCLLDQGFPKPRSHIP------------------------------------YLTLEK-LSQLRYIDCIIKEVL-RFLPPVS-GGYRTALKTFEL-DG--YQIPK------G-----------WSVMYSIRD-THETAAVFQSPEMFDPD------RF--GPE--RE-ESRA------S--RFSYVPFGGG-----------VRRCIGKELAQ-IILKTLAVELIGTCKWT----LATQ---NFPKMQTVP-----------IVHPVN----GLHV--R--F-----SYKNP- Kryptolebias_marmoratus_CYP1C2 ------RRLPG------------P-FAWPVVGNA----------LQL-----GQMPH--------ITFSNLAK-----KYGDI--YQIRLGCSDIVV-LNGARVIRQALIE--HS---TEFAGRPNFVSFQ----LVSG---GKSLTFTSYSKQ-WSIHRKIAQTTIRAFSTAN---SQTKKAFEHQIVAEVKELVGIFLKL-----------SAQGQY-----FNPGHELTVAAANVICALCFGKRYG----HDDPE------FRALL----HQVDQFGQTVGA--GSLV--DVMPWLQS--FPNPVRSIFKSFKCLN--EEFFEFVRSKVEEHRKTFDPKVI----------------R-----DMSDA-I---IDAF------------------NE---------------------------T-DSVTELTKDYTEATVADLIGAGMDTVSTALHWILLLLAKHPDIQTKLQELIDKV--V-G--------------------------------------------------------------RNR----------LPSVED-RPHLPYLDAFIYETM-RFTSFVPVTIPHSTTTDVSI-NG--LKIPK------D-----------TVVFINQWS-VNHDPLKWKDPHIFNPS------RF--LDI--ND--SLD------RDITNNVMIFSAG-----------KRRCIGDQIGK-TQIFLFFAILLHQCSFE----KCPD---EDFSLNCSY--------G--LTLKPL----NYKI--T--A-----KLRGE- Kryptolebias_marmoratus_CYP1C1 ------RRLPG------------P-FAWPVVGNA----------MQL-----GQMPH--------ITFAKLAK-----KYGNV--YQIRLGCSDVVV-LNGDRAIHQALIQ--HS---TEFAGRPNFVSFQ----MISG---GRSMTFTNYSKQ-WKAHRRVAQSTLRAFSSAN---SQTKKAFEQHVLAEATELVQVFLRQ-----------SANGQY-----FYPAYEFTVAAANIMCALCFGMRYG----HDDQE------FRTLL----HRVDKFGETVGA--GSLV--DVMPWLQS--FPNPVRNVYEAFKSLN--EEFFTYVKDKVVKHRETFNPEVT----------------R-----DMSDA-I---IRAI-----------------------------------------------EHGEGSILSKEFVEATVTDLIGAGQDTMSTVMQWIVLLLVKYPDMQAKLQQLIDKV--V-G--------------------------------------------------------------PDR----------LPSVED-RSSLALVDAFIFETM-RFTSFVPVTIPHSTTSDVVI-ED--LYIPK------D-----------TVVFINQWS-VNHDPQKWKDPHVFDPT------RF--LDE--NG--ALD------KDKTNSVMIFSTG-----------KRRCIGVQIAK-VQVFLFTAVLLHQCNFE----SNPS---EPLTFDCSY--------S--LTLKPN----RFCV--R--T-----KLRGK- Oryzias_latipes_CYP1C1 ------RRLPG------------P-FAWPLVGNA----------MQL-----GQMPH--------ITFSKLAK-----KYGNV--YQIRLGWSDVVV-VNGDRSIREALIQ--HS---IEFAGRPNFVSFQ----MISG---GRSLTFTNYSEQ-WKAHRKLAQSTLRAFSSAN---SQTKKTFEQHIVDEATELVKVFLQR-----------SSTGQY-----FHPAHEFTVAAANIMCALCFGMRYG----HDDLE------FTTLL----QRLDRFGETVGA--GSLV--DVMPWLKS--FPNPVRSLYENFKNLN--EEFFIFIKDKVLQHRATFNPKVT----------------R-----DISDA-I---INVI-----------------------------------------------EHGEDSKLSKDFVEATVTDLIGAGQDTMSSFMQWIILLLVKYPDVQAKLQQLIDRV--V-G--------------------------------------------------------------RER----------LPSTED-RNNLALLDAFIYETM-RFTSFVPVTIPHSTTSDVTI-GS--LHIPK------D-----------TVVFINQWS-VNHDPLKWKEPHVFDPT------RF--LDE--NG--GLD------KDKINSVMIFSTG-----------KRRCIGDQIAK-VQVFIFTAVLLHQCSFE----SDPS---EPVTLDCSY------------------------------------------ Danio_rerio_CYP1C1 ------KRLPG------------P-FAWPLVGNA----------MQL-----GQMPH--------ITFSKLAK-----KYGNV--YQIRLGCSDIVV-LNGDAAIRKALVQ--HS---TEFAGRPNFVSFQ----MISG---GRSSTFTNYSKQ-WKTHRKVAQSTLRAFSMAN---SQTRKTFEQHVVGEAMDLVQKFLRL-----------SADGRH-----FNPAHEATVAAANVVCALCFGKRYG----HDDPE------FRTLL----GRVNKFGETVGA--GSLV--DVMPWLQS--FPNPVRSVYQNFKTIN--KEFFNYVKDKVLQHRDTYDPDVT----------------R-----DMSDA-I---IGVI-----------------------------------------------EHGKESTLTKDFVESTVTDLIGAGQDTVSTAMQWMLLLLVKYPSIQSKLQEQIDKV--V-G--------------------------------------------------------------RDR----------LPSIED-RCNLAYLDAFIYETM-RFTSFVPVTIPHSTTSDVTI-EG--LHIPK------D-----------TVVFINQWS-VNHDPQKWSDPHIFNPS------RF--LDE--NG--ALN------KDLTNSVMIFSTG-----------KRRCIGEQIAK-VEVFLFSAILLHQCKFE----RDPS---QDLSMDCSY--------G--LALKPL----HYTI--S--A-----KLRGK- Danio_rerio_CYP1C2 ------KRLPG------------P-FAWPLIGNA----------MQL-----GQMPH--------ITFSKLAK-----KYGNV--YQIRLGSSDIVV-LNGESAIRSALLQ--HS---TEFAGRPNFVSFQ-----YVS--GGTSMTFASYSKQ-WKMHRKIAQSTIRAFSSAN---SRTKKSFEKHIVAEAVDLVETFLKS-----------QH---------FNPSHELTVAAANIICALCFGKRYG----HDDLE------FRTLL----GNVNRFSETVGA--GSLV--DVMPWLQT--FPNPIRSIFQSFKDLN--NDFFSFVKGKVVEHRLSYDPEVI----------------R-----DMSDA-F---IGVM-----------------DH----------------------------A-DEETGLTEAHTEGTVSDLIGAGLDTVSTALNWMLLLLVKYPSIQSKLQEQIDKV--V-G--------------------------------------------------------------RDR----------LPSIED-RCNLAYLDAFIYETM-RFTSFVPVTIPHSTTSDVTI-EG--LHIPK------D-----------TVVFINQWS-VNHDPQKWSDPHIFNPS------RF--LDE--NG--ALD------KDLTSSVMIFSIG-----------RRRCIGDQIAK-VEVFLISAILIHQLTFE----SDPS---QDLTLNCSY--------G--LTLKPF----DYKI--S--A-----KPRGS- Danio_rerio_CYP1B1 ------QLVPG------------P-FSWPVIGNA----------AQL-----GNTPH--------FYFSRMAQ-----KYGDV--FQIKLGSRNVVV-LNG-DAIKEALVK--KA---TDFAGRPDFASFR-----FVS--NGKSMAFGNYTPW-WKLLRKVAQSTVRNFSTAN---IQTKQTFEKHIVSEIGELIRLFLNK-----------SREQQF-----FQPHRYLVVSVANTMSAVCFGNRYA----YDDAE------FQQVV----GRNDQFTKTVGA--GSMV--DVMPWMQY--FPNPIRTLFDQFKELN--KEFCAFIELKVSEHRKTISPSHV----------------R-----DMTDA-F---IVAL------------------DKGLS------------------------G-GSGVSLDKEFVPPTISDIFGASQDTLSTALQWIILLLVRYPEIQNRLQEDVGRV--V-D--------------------------------------------------------------RSR----------LPTIAD-QPHLPYLMAFIYEVM-RFTSFTPLTIPHSTTKDTSI-NG--YPIPK------D-----------TVIFVNQWS-LNHAPAKWDQPEVFNPQ------RF--LDE--DG--SLN------KDLTTNVLIFSLG-----------KRRCIGEDVSK-IQLFLFTSVLVHQCSFK----AEST-----PNMDYEY--------G--LTLKPK----PFKV--S--V-----TARDS- Takifugu_rubripes_CYP1B1 ------GCPPG------------P-RAWPIIGNA----------AQL-----GHAPH--------LYFTRMAQ-----RFGNV--FQIKLGSRTVVV-LNG-DAIKQALVR--KG---LEFAGRPDFTSFK-----YIS--NGHSLAFGTVTDW-WKSHRRVAQSTVRMFSTGN---LQTKKTFERHLTCEVRELLHLFLGK-----------TKELQY-----FQPMNYLVVSTANVISAVCFGKRYS----YEDEE------FQQVV----GRNDQFTRTVGAGSIV----DVMPWLQY--FPNPVKSIFDNFKRLN--KEFSDFIRDKVTEHRKSIRPSSV----------------R-----DMTDA-F---IVSL-----------------DKLSEK---------------------------TGVPLWKDYVIPTVGDVFGASQDTLSTALQWIFLVLVRYPDMQQRLQEEVDLV--V-G--------------------------------------------------------------RQR----------LPCIED-QQQLPWVMAFIYEVM-RFTSFVPLTIPHSTTTDTTI-MG--YTIPK------N-----------TIIFINQWS-VNHDPTIWSHPETFDPN------RF--LNP--SG--SLN------KDLTSRMLIFSMG-----------KRRCIGEELSK-LHLFLFTALIGHQCHIT----DDPA---KPTTMDYNY--------G--LTLKPR----GFYV--A--L-----TLRGD- Kryptolebias_marmoratus_CYP1B1 ------SGLPG------------P-FSWPLIGNA----------AQL-----GNAPH--------LFFARLVQ-----KFGNV--FQIRLGSQAVVV-LNG-AAIRQALIK--QG---LDFAGRPDFTSFR-----FIA--DGDSMAFGTVTER-WKTHRRVAQSTVRMFSTGN---PQTRRTFEQHVLCEFRELLRLFVER-----------TRAERF-----FQPMTFLVVSTANVMSAVCFGKRYS----YQDDE------FRDVV----GRNDKFTQTVGAGSIV----DVMPWLQY--FPNPIRTMFEEFKKLN--QDFSLFIRDKVLEHRKTLESSTF----------------R-----DMTDA-F---IVAL-----------------DRIPDR---------------------------TGPPAAKDDVSPAIGDIFGASQDTLSTALQWIVLILVKFPQMQERLQQEVDRV--V-D--------------------------------------------------------------RDR----------LPSAED-MSRLPYVMAFIYEMM-RFTSFVPLTIPHSTIKDTSI-MG--HSVPK------N-----------TVIFINQWS-VNHDPTYWSNPENFDPE------RF--LDP--QG--SLN------KDLTSSVLIFSLG-----------RRRCIGEELSK-MQLFLFTALLAHQCHIR----PDPT---RTLSLDYSY--------G--LTLKPH----AFSI--A--V-----SLRED- Oryzias_latipes_CYP1B1 ------PRLPG------------P-FAWPLIGNA----------AQL-----GNAPH--------LYFMRMVK-----KYGTV--FQIQLGSRAVVV-LNG-DSIRQALVK--QG---PDFAGRPDFTSFR-----FIA--NGDSLAFNTVSDW-WKTHRRVAHSTVRMFSTGN---PQTKKTFEQHVLSEFKELLGLFVAK-----------TREVQF-----FQPMTYLVVSTANVMSAVCFGKRYS----YDDEE------FRQVV----GRNDQFTQTVGA--GSIV--DVMPWLQY--FPNPIKTIFDNFKKLN--REFSDFIHDKVVEHRKTMESCTM----------------R-----DMTDA-FIVALDQI-------------------------------------------------RNKTGALKDYVVPTLGDIFGASQDTLSTAKQWIILVLVKYPEIQQRLQKEVDRV--V-G--------------------------------------------------------------RER----------LPSIED-QPQLPYIMAFIYEVM-RFTSFVPLTIPHCTVTDTSI-MS--YPIPK------N-----------TVIFINQWS-INHDPSMWAHPDTFDPE------RF--LDP--EG--KLN------KDLTSNVLIFSLG-----------KRRCIGEELSK-LQLFLFVALIAHQCNIT----THPE---RSPTLEYSY--------G--LTLKPH----AYVI--A--V-----SLRQD- Kryptolebias_marmoratus_CYP1A ------RRLPG------------P-RALPVIGNM----------LEL-----GRKPY--------LSLTEMSK-----RYGEV--FQVQLGSRPVVV-LSGYETVKQALTK--QG---DDFSGRPDLYSFS-FI--NDGKSLA---FSTDKAGI-WRTRRKLAYSALRSFSNLEGTTSEYSCVLEEHICKESGYLIKELNNVMKT--------EGK--------FDPFRYIVVSVANVICGMCFGRRYD----HHDQE------LLGLI----NLSEDFVKVTGS--GNPA--DFIPALQY--LPDK---AMKKFVDIN--SRFCNFVQKIVSEHYITFDKDNI----------------R-----DITDS-L---IDHC-----------------EDRKLD------------------------E-NSNVQISDEKIVGIVNDLFGAGFDTISTGLSWAVMYLVAYPEIEERLFTEIKEK--I-G--------------------------------------------------------------LDR----------TPTLSD-RNNLPLLEAFILELF-RHSSYLPFTIPHCATKDTSL-NG--YFIPK------D-----------TCVFINQWQ-INHDPELWEDPSSFIPD------RF--LSD--DG-TEVN------KLDGEKVVIFGLG-----------RRRCIGEVIAR-NEVFLFLAIIIQKLHFY----QLPG---EPLDLTPEY--------G--LTMKHK----RCHL--G--V-----KLRDE- Danio_rerio_CYP1A ------QKLPG------------P-KPLPIIGNV----------LEI------GNNP------H-LSLTAMSK-----CYGPV--FQIQIGMRPVVV-LSGNDVIRQALLK--QG---EEFSGRPELYSTK-FI--SDGKSLA---FSTDQVGV-WRARRKLALNALRTFSTVQGKSPKYSCALEEHISNEGLYLVQRLHSVMK---------ADG--S-----FDPFRHIVVSVANVICGICFGRRHS----HDDDE------LVRLV----NMSDEFGKIVGS--GNPA--DFIPFLRI--LPST---TMKKFLDIN--ERFSKFMKRLVMEHYDTFDKDNI----------------R-----DITDS-L---INHC-----------------EDRKLD------------------------E-NSNLQVSDEKIVGIVNDLFGAGFDTISTALSWAVVYLVHYPEVQERLQRELDEK--I-G--------------------------------------------------------------KDR----------TPLLSD-RANLPLLESFILEIF-RHSSFLPFTIPHCTSKDTSL-NG--YFIPK------D-----------TCVFVNQWQ-VNHDPELWKDPSSFIPD------RF--LTA--DG-TELN------KLEGEKVLVFGLG-----------KRRCIGESIGR-AEVFLFLAILLQRLKFT----GMPG---EMLDMTPEY--------G--LTMKHK----RCLL--R--V-----TPQPG- Takifugu_rubripes_CYP1A1 ------RRLPG------------P-TPLPIMGNV----------LEI-----G???F--------?SLTAMSK-----RYGDV--FQIQIGTRPVIV-LSGIETVRQALVK--QG---EEFSSRPDLYSFR-FI--NEGKSLS---FSTDQAGV-WRARRKLAYNALRSFSTLQGTTPEYSCMLEEHICKEGEYLVNRLSSV-----------LQADGR-----FEPFPHIVVSVGNVICGMCFGRRYD----HDDQE------LVSLV----NLSNEFGKVVSS--GNPA--DFIPALRF-LLSST----MKSFVDLN--TRFTTFVQKIVNEHYATFDKENI----------------R-----DITDS-L---IDHC-----------------EDRKLD------------------------E-NSNIQVSDEKIVGIVNDLFGAGFDTVSTALSWSIMYLVTYPDVQERLYQELKSN--V-D--------------------------------------------------------------QNR----------KPRLSD-KPNLPLLEAFILELF-RHSSFLPFTIPHCTSKDTSL-NG--YFIPK------D-----------TCVFINQWQ-INHDPEQWEDPSSFNPD------RF--LSA--DG-TEVN------KAEGEKVTTFGMG-----------KRRCIGEIIAR-NEVYLFLAILIQRLQFL----PIPG---ETVDMTPEY--------G--LTMKHK----DCRLKAR--M-----RTRDE- Danio_rerio_CYP1D1 ------PVPPG------------P-RPWPIVGNF----------LQM-----EEQVH--------LSLTNLRV-----QYGDV--FQVKMGSLVVVV-LSGYTTIKEALVR--QG---DAFAGRPDLYTFS-AV--ANGTSMT---FSEKYGEA-WVLHKKICKNALRTFSQTEPKDSNASCLLEERICVEAIDMVETLKAQ-----------GEEFGD---SGIDPVQLLVTSVANVVCTLCFGKRYS----HNDKE------FLTIV----HINNEVLRLFAAGNLA----DFFPIFRY--LPSP---SLRKMVEFI--NRMNNFMERNIMEHLVNFDTNCI----------------R-----DITDA-----LIAM----------------CEDRQED--------------------------KESAVLSNSQIVHSVIDIFGAGFDTIITGLQWSLLYLIKFPNIQDKIVQEIDNQ--V-G--------------------------------------------------------------MDR----------LPQFKD-RPNMPYTEAFINEVF-RHASYMPFTIPHCTTENITL-NG--YFIPK------D-----------TCVFINQYQ-VNHDIEIWDDPESFRPE------RF--LTL--SG--HLN------KSLTEKVMIFGMG-----------IRRCLGDNIAR-LEMFVFLTTLLHRLHIE----NVPG---QELDLSSTF--------G--LTMKPR----PYRI--K--I-----IPRN-- Kryptolebias_marmoratus_CYP1D1 ------PAPPG------------P-TPWPLVGNL----------LQM-----GDQMH--------LCLTHLGH-----QYGDV--FQLRLGSLNVVV-LSGFTTIRQALVR--QG---EEFAGRPELFTFS-AV--ADGNSMT---FSEKYGPA-WLLHKKLCKNALRSFSQAEPRGSGATCLLEEHICAEATEMVEVIREQ-----------AVKDSD--KMGIDPSLSLVTCVANVVCSLCFGRRYD----HDDKE------FLTIV----NINNEVLKLFAAGNLA----DFFPVFRY--FPSP---SLKKLVQYI--RRMNGFMERRIEEHVSSFDKNYI----------------R-----DITDA-----LIAL----------------CEDREDN--------------------------KETSLLSNSQIIRTVIDIFGAGFDTIFAGLQWSLLYLIKFPDIQDKIHQEIDDH--I-G--------------------------------------------------------------SAR----------LPRFSD-KPKMPLTEAFIHEVF-RHSSYVPFTIPHCTTRDAIL-NG--YFIPK------D-----------TCVFINQHQ-VNHDVDLWGDPEKFRPE------RF--LGP--SG--QLN------KELTEKVLIFGVG-----------KRRCVGDGFAR-LEMFVFLTTLLHGLKLE----SVPG---QKLDLSADF--------G--LTMKPH----PYRI--T--V-----SSRF-- Oryzias_latipes_CYP1D1 ------PSPPG------------P-TPWPIVGNL----------FQM-----GNQMH--------LSLTLLRA-----KHGDV--FKLRLGSLPVVV-LSGYNTIRQALVR--QG---EDFAGRPELFTFS-AV--ADGTSMT---FSEKFGPA-WLLHKKLCKNALRSFSQAAPRGSGATCLLEEHVCAEAAEMLEMIREQSAKVELDSEMTDGASKG-----VDPVKPLVTSVANVVCALCFGKRYD----HNDKE------FLTIV----NINNEVLKLFAAGNLA----DFFPVFRY--FPSL---SLKELVQYI--RRMNGFMERRIEEHMHTFDKNYI----------------R-----DITDA-----LIAL----------------CEDREKS--------------------------KEMSLLSDTQIIHSVIDIFGAGFDTIIAGLQWSLLYLIKFPDVQRRIHQEIDEH--I-G--------------------------------------------------------------SAR----------MPNFSD-KSKMPFTEAFIYEVF-RHAAYVPFTIPHCTTRHTTL-NG--YFIPK------D-----------TCVFINQYQ-VNHDKDLWGDPEQFCPD------RF--LGH--SG--QLN------KELTEKVLIFGMG-----------KRRCLGDGFAR-LEMFVFLATLLHGLRIE----NVPG---QKLDLGTDF--------G--LTMKPH----PYKI--T--V-----SSRFT- Danio_rerio_CYP2U1 ------NIPPG------------P-KPWPIVGNFGGFLVPPFILKRFVKNSKEFAKVVSNPLSPQAGLIEMSK-----LYGNI--FSIFVGPQLMVV-LTGYDAVRDAMLN--HT---ETFSDRPHIPLVT-IITKRKG------IVFAPYGPL-WRTNRRFCHSTLRSFGFGR-------MSLEPCIHEGLAIIKTELQSL-----------IETAGP---SGIDLTPLISNAVSNIISLMSLGQRFH----HEDKE------FRNMR----DLMSHGLEISVNTSILLV--NVFPWLYY--LPFG---VFKELRRAE--LDITAFLKRIIARHRATLDPENP----------------R-----DFIDM-Y---LVEM---------------LAKQKEGS--------------------------SEENLFSEDDLFYIIGDLFIAGTDTTTNSMLWSILYMSLYPDVQEKVQKEIDAV--V-G--------------------------------------------------------------SER----------VPSLTD-KSSLPYTEATIMEVI-RMTVVVPLSIPHMASETTEF-RG--FTIPK------G-----------TVIIPNLWS-VHRDPTVWENPDDFNPS------RF--LDD--QG--KIL------R--KDCFIPFGLG-----------RRVCMGEQLAK-MELFLMFTSLMQTFTFR----FPEG--ATAPSMHGRF--------G--LTLAPC----PFTV--C--V-----KTR--- Takifugu_rubripes_CYP2U1 ------NIPPG------------P-KPWPVVGNFGGFLVPSAIRKRF-----GSKAEGPAKNAA-AVLTELAK-----VYGNV--YSIYVGSQLVVV-LNGYKVVRDALSN--HP---DVFSDRPDIPAIS-----IMTKRKG--IVFAPYGPL-WQKHRRFCLSTLRNFGLGR-------LGLEPCIVEGLTNIKTELLRL-----------EEESGGAG---VDPAPVISNAVSNVICSLVLGHRFN----HDDQE------FRSML----RLMDRGLEICVNSPAVLI--NVFPLLYH--LPFG---VFRELRQVE--RDITAFLKRFIANHQETLDPNNP----------------R-----DLTDM-Y---LKEI----------------SARREAG--------------------------DVDSGFTEDYLFYIIGDLFIAGTDTTANSVLWVILYMASYPDIQDKVQAEIDGV--V-G--------------------------------------------------------------PLR----------TPSLSD-KGKLPFTEAAIMEVQ-RLTTVVPLAIPHMTSETIEF-MG--YTIPK------G-----------TVVLPNLWS-VHRDPTEWDDPDSFDPT------RF--LDE--DG--TLL------R--KECFIPFGIG-----------RRVCMGAQLAK-MELFLTVTNLLQTFHFR----LPEG--APRPPLQGRF--------G--LTLAPC----PYTV--C--I-----NPR--- Oryzias_latipes_CYP2U1 ------NIPPG------------P-KPWPVVGNF-GNFFVPPSVRTK-----IAGQPNSTNAIEIEALRQQAT-----VFGNI--HSLFIGGQLIVV-LHGFHLIRDALLN--QP---EVFSDRPDIPLVT-ILTKRKG------IVFAPYGPV-WRKQRKFCHTTLRSFGLGK-------LSLEPCIQRGLAGVKAELLRL-----------NEERGS-AG--VDPATLIGNSVSNVICSLILGQCFH----HHDVE------FRTMI----RLMEHGLKICINSPAVLI--NIFPLLYY--LPFG---VFKELRQVE--RDITAFLKRIIAKHRDTLDPDNP----------------R-----DLTDM-Y---LIEM----------------LTQQAAG--------------------------EEDSSFTDDYLFYVIGDLFIAGTDTTTNSILWFLLYMILHPDVQDKAQAEIDGV--V-G--------------------------------------------------------------KHR----------VPSVTD-KGSLPFTEATIMEVQ-RLHSVVPLAIPHMTSETTVF-RG--YTIPK------G-----------TVIFPNLWS-VHRDPTLWEDADSFNPS------RF--LDN--EG--NLL------R--KEYFIPFGIG-----------RRVCMGEQLAK-MELFLTVTTLLQAFKFR----HPEG--NPPPTVKERF--------G--LTMAPC----PFSV--C--V-----TPRGG- Kryptolebias_marmoratus_CYP2U1 ------NIPPG------------P-KPWPVVGNFGGFLVPPALRGRF-----GQRRD---HVSVMEALTSQAD-----LYGNI--YSLFVGSQLAVV-LNGYEVVRDALSN--HP---DVFSDRPDVPSIS-ILTKRRG------IVFAPYGPV-WRKQRKFCHTTLRSFGLGK-------LSLEPCIQRGLVTIKAELLRL-----------NGESGG---TGVDPAPLISNAVSNVVCSLILGQRFH----HGDPE------FRAIL----GLMARGLEICINSAAILI--NVCSLLYY--LPFG---VFKELRQVE--RDITVFLKRIIANHRETLDPENP----------------R-----DLADM-Y---LIEM----------------LARRAAG--------------------------EEDSSFTEDYLFYIIGDLFIAGTDTTTNSVLWTLLYMALYPDVQDKVQAEIDKV--V-G--------------------------------------------------------------RRR----------LPSVTD-RGSLPFTEATIMEVQ-RLAVVVPLSVPHMASETTEF-RG--YTIPK------G-----------TVIFPNLYS-VHRDPAVWDEPDSFNPT------RF--LDD--EG--KLL------K--KEFFIPFGIG-----------RRVCMGEQLAK-MELFLTVTGLLQSFRFR----LPDG--TPPPSLQGRF--------G--LTMAPC----PFRV--C--V-----NDRSE- Danio_rerio_CYP2X10.1v1 ------NFPPG------------P-APVPIFGNL----------LQL-----NRISP------L-KDFDKFAQ-----HYGSI--YGIYIGSQPAVV-LTGQKMIKEALIT--QA---AEFSGRSNNMMFS-HV--TGG--KG--VIMADYGES-WREHRRFALTTLRNFGLGK-------KSMEQRILEEVKHICLLLEES-----------AGK--S-----IDPQHLYHQAASNIIASVIFGSRFN----YKDAY------FQTLI----TSVEDLTKITIGPWAMLY--EIAPVLRI--FPLP----FQKAFQYF--EQITKHVLKVVEEHKTSRVAGEP----------------R-----DLIDC-Y---LEEM-----------------ENKSDH----------------------------RTSFDESQMVTLLFDLFIAGTETTSNTLRTLTLYLMTYTHIQEQCQREIDEV--L-G--------------------------------------------------------------ARD----------HVTYED-RNAMHFVQAVIHEGQ-RVADIAPLSMFHSAKTDTQL-RG--YSIPK------G-----------TIIIPYLSS-----------------S----------LRE--EG-------------------------------------VC-------------YISSIKQYYE-------------------------------------------DLVF-----V----------- Danio_rerio_CYP2X10.2v2 ------NFPPG------------P-APVPIFGNL----------LQL-----NRISP------L-KDFDKFAQ-----HYGSI--YGIYIGSQPAVV-LTGQKMIKEALIT--QA---AEFSGRSNNMMFS-HV--TGG--KG--VIMADYGES-WREHRRFALTTLRNFGLGK-------KSMEQRILEEVKHICLLLEES-----------AGK--S-----IDPQHLYHQAASNIIASVIFGSRFN----YKDAY------FQTLI----TSVEDLTKITIGPWAMLY--EIAPVLRI--FPLP----FQKAFQYF--EQITKHVLKVVEEHKTSRVAGEP----------------R-----DLIDC-Y---LEEM-----------------ENKSDH----------------------------RTSFDESQMVTLLFDLFIAGTETTSNTLRTLTLYLMTYTHIQEQCQREIDEV--L-G--------------------------------------------------------------ARD----------HVTYED-RNAMHFVQAVIHEGQ-RVADIAPLSMFHSAKTDTQL-RG--YSIPK------G-----------TIIIPYLSS-SLREEGQWKFPHEFNPQ------NF--LNE--KG--EFV------K--NDAFMPFSAG-----------PRVCLGENLAR-MELFLILVTVLRRFRLV----WPKD--AGEPDFTYIY--------G--GTQSVK----PYRV--I--V-----EPRMH- Danio_rerio_CYP2X12c2 ------DFPPG------------P-APVPFFGNL----------LQL-----NRINP------I-KDLDKFAQ-----HYGSI--YGIYIGSKPAVV-LTGQKMIKEALIT--QA---AEFAGRPNHMMIS-HI--TRS--KG--VIMADYGES-WREHRRFALTTLRNFGLGK-------KSMEQRILEEVKHICLLLEES-----------AGK--S-----IDPQHLYHQAASNIIASVIFGSRFN----YKDEY------FQTLI----QTMEKLTKIAIGTWAMLY--EIAPVLRI--FPLP----FWKAFHYF--EKITRHSLKVVEEHKKSFVAGEP----------------K-----DLIDC-Y---LEEM-----------------KKRADQ----------------------------RTTFDEAQMVTLLFDLFLAGTETTSNTLRTLTLYLMTHTHIQEQCQREIDEV--L-G--------------------------------------------------------------ARD----------HVTYED-RNDMHFVQAVIHEGQ-RVADIVPLNVFHTARTDTQL-RG--YSIPK------G-----------TIIIPYLSS-SLREESQWKFPHEFNPQ------NF--LNE--KG--EFV------K--NEAFMPFSAG-----------PRVCLGENLAR-MELFLILVTVLRKFRLV----WPKD--AGEPDFTYIY--------G--GTQSLK----PYPM--I--V-----ELRTP- Danio_rerio_CYP2X12c1 ------NFPPG------------P-APVPIFGNL----------LQL-----NHINP------I-KDLDKFAQ-----HYGSI--YGIYIGSKPAVV-LTGQKMIKEALIT--QG---AEFAGRSNKMMVS-HV--TRS--KG--VIMADYGES-WREHRRFALTTLRNFGLGK-------KSMEQRILEEVKHICLLLEES-----------AGK--P-----IDPQHLYHQAASNIIASIIFRSRFD----YQDEY------FQTLI----TTMEKLTKIAIGPWAMLY--EIAPVLRI--FPLP----FHKAFQYF--EQITNHVLKVVEEHKTSRVAGEP----------------R-----DLIDC-Y---LEEM-----------------NRRSDK----------------------------HTTFDESQMVTLLFDLFIAGTETTSNTLRTLTLYLMTYTHIQEQCQREIDEV--L-G--------------------------------------------------------------ARD----------HVTYED-RNAMHFVQAVIHEGQ-RVADIVPLSMFHTARTDTQL-RG--YSIPK------G-----------TIIIPYLSS-SLREEGQWKFPHEFNPQ------NF--LNE--KG--EFV------K--NDAFMPFSAG-----------PRVCLGENLAR-MELFLILVTVLRKFRLV----WPKD--AEEPDFTYIY--------G--GTQSLK----PYPM--I--V-----KLRTP- Danio_rerio_CYP2X9 ------NFPPG------------P-RPLPLFGNL----------LEL-----NINNP------L-KDFERLAN-----RYGNI--YSLYFGSKPWVV-LNGFEALKEALVT--KA---VDFAGRPQDLMVN-RV--TKG--GG--VILSDYGPS-WKEHRRFALMTLRNFGLGK-------QSMEERILGEVSHIIDKLEKR-----------VGT--A-----FDPQTMFHNAASNIICIVLFGSRYD----YDDEF------LKLFI----HLYTENAKIANGPWAMIY--DTFPMFRY--LPLP----FRKAFANA--SKARELSTQLVKEHKKTWVPGEP----------------R-----DFIDC-Y---LDEL-----------------DKRGND----------------------------GSSFSEAQLILYVLDLHFAGTDTTSNTLLTGFLYLMTHPEVQAKCQQEIDDV--L-E--------------------------------------------------------------DKD----------QASYED-RHSMPYTQAVTHEVQ-RVANTVPLSVFHCTTKDTEL-MG--YNIPK------G-----------TFVIPNLGS-ALKEEGQWKFPHEFNPA------NF--LNE--QG--EFE------K--PEAFVPFSAG-----------PRVCLGEGLAR-MELFLVMVTLLRRFQFV----WPND--AGKPDYTPVY--------G--VTLTPQ----PYRM--H--I-----KRRET- Danio_rerio_CYP2X8 ------NFPPG------------P-SPLPIFGNL----------LHF-----NLANP------L-KDFERFAE-----KYGNI--FSLYTGSRPAVF-LNSFAVIKEALVT--KA---QDFSGRPQDFMIS-HL--TEC--KG--VVLADYGPL-WKDHRRFALMTLRNFGLGK-------QSMEERILGEISHVVCYLDKN-----------IGK--T-----VDPQVMFHNVASNVISLVLFGRRFD----YNSET------LQCYI----QLITEISKILNGPWNMIY--DTLPFLRI--LPLP----FKKGFDHV--KVLKGMNLKLIDEHKSTRVPGKP----------------R-----DFIDC-Y---LDEL-----------------DKRKNE----------------------------VSTFSEDQLLMYILDLYFAGTDTTSNTLLTAFLYLMNHPEVQVKCQQEIDDV--LEG--------------------------------------------------------------KDQ-----------VSYED-RDNMPYTLAVIHEVQ-RVANTVPLSVFHCTTRDTEL-MG--YSIPK------G-----------TLIIPNLTI-VLKEEGQWKFPHEFNPA------NF--LNE--QG--QFE------K--PEAFIPFSTG-----------------------FKSRIYTTG----FTFN-----------------------------------------SFQF-----L-----RKKNK- Danio_rerio_CYP2X7 ------NFPPG------------P-PPVPIFGNL----------LQI-----NMVDP------L-KEFERLAE-----KYGNI--FSLYTGSKPAVF-LNNFEVIKEALVT--KA---QDFSGRPQDLMIS-HL--TGN--KG--VVLADYGPL-WKDHRRFALMTLRNFGLGK-------QSMEERILGEISHIVDFLDKN-----------TGK--T-----VDPQIMFHNIASNVINLVLFGCRFD----YNNEF------LRGYI----QRIAENLRILNGPWNMIY--DTFPLLRI--LPLP----FKKAFDNV--KIIKSMNRKLIDEHKSTRVPGQP----------------R-----DFIDC-Y---LDEL-----------------DKVKNC----------------------------VSTFSEDQLIMNIMDMSFAGTDTTSNTLLAAFLYLMNHPEVQVKCQQEIDDV--LEG--------------------------------------------------------------KDQ-----------VTYED-RHNMPYTLAVIHEVQ-RVANIVPLSVLHCTTRDTEL-MG--YSIPK------G-----------TVIIPNLTV-VLKEEGQWKFPHEFNPA------NF--LNE--QG--QFE------K--PEAFIPFSTG-----------PRVCLGEGLAR-MELFLIFVTLLRRFQFV----WPED--AGKPDYTPVF--------G--LTMTPK----PYRM--H--I-----RRRDT- Danio_rerio_CYP2X6 ------NFPPG------------P-PPVPIFGSL----------LQL-----NLANP------L-KDFEKFAE-----KYGEI--FSLYTGSRPAVI-LNSFAVIKEALVT--KA---QDFSGRPQDFMIS-HA--TEN--KG--IVLADYGPV-LKGHRRFALMTMRNFGLGK-------QSMEERILGEISHVVDYLDKN-----------AGK--R-----VDPHIMFHNVASNVISLLLFGCRFD----YNSEF------LQCYI----QLINEISKIINGPWNMIY--DTFPLLRI--LPLP----FKKAFDHV--KVIKSMNLKLIDEHKSTRVPGEP----------------R-----DFIDC-Y---LDEL-----------------DKGKNC----------------------------VSTFSEDKLLMSIMDLHFAGTDTISNTLLTAFLYLMNHPEVQVKCQQEIDDV--LEG--------------------------------------------------------------KDR-----------VMYED-RHNMPYTLAVIHEVQ-RVANTVPLSVFHSTTRDTEL-MG--YSIPK------G-----------TIIIPNLTR-VLKEEGQWKFPYEFNPA------NF--LNE--QG--QFE------K--PEAFIPFSTG-----------LRMCLGEGLAR-MELFLIFVALLRRFQFE----WPVD--AGKPDYTPVF--------G--LTLTPK----PYRM--H--I-----RRRET- 'Takifugu rubripes CYP2X-like' ------NFPPG------------P-PVLPLLGSI----------LEL-----ALDNP------L-QDFERLRK-----KYGNV--YSLFLGTRPAVV-ISGLKNIKEALVT--KG---SDFSGRPQDMFIN-DA--IKT--NG--VIMQDYNLV-WKEHRRFALTTMRNFGMGK-------TSMEDRIHGEIEYIVNTLEKN-----------NGK--T-----LSPHLMFHNAASNIICQVLFGTRYE----YDDHF------IREIV----RCFTENAKISNGPWAMLY--DSIPLVRY--LPLP----FKNAFKNV--ETAENLVKDLFVEHKKTRMSGDP----------------R-----DFVDC-Y---FDEL-----------------DKRGKD----------------------------RSSFSENMLTMYALDLHFAGTDTTSNTLLTGFLYLMNYPHIQERCHQEIDKV--L-Q--------------------------------------------------------------DNE----------TVTYDA-RNQMPYMQAVIHEVQ-RVANTVPLSVFHCTTKDTEF-MG--YSIPK------G-----------TLIIPHLAS-VLKEEGQWKFPNEFNPD------NF--LND--DG--EFV------K--PEAFMPFSTG-----------PRVCLGEGLAR-MELFLIIVTLLHKFQFI----WPED--AGEPDYTPIF--------G--ATQTPK----PYRM--K--I-----QLRK-- Oryzias_latipes_CYP2X20 ------NFPPG------------P-LSLPVLGNL----------LHL-----NLKNP------L-VDFEKMKE-----SYGNV--YSFFIGSRPAVV-VNGLQAMKEAIMI--KA---TDFSGRPQDMFVS-DL--TQR--KG--VILVDYGSV-WRDHRRFALMTLRNFGLGK-------ISMEERIHEEIQFTISKLEEN-----------IGK--T-----LSPKFMFHNAASNIICKVLFNTRYD----YEDGK------ISEIV----QGFVEMLQIANGPWAMMY--DAFPWIRS--FPLP----FNKAFRNM--ENFLNLAKRLVNEHKMSRVAGEP----------------R-----DFVDS-Y---LDEL-----------------EKNKKD-------------------------------FSEQQLLRMTFDLYIAGTDTTSNTMLAGFLYLMVYPHIQEKCQREIDQM--L-E--------------------------------------------------------------RKD----------RVSFED-RHKMPYMQAVIHEVQ-RFANIVPLSVFHCTTKDSEL-SG--YTIPK------G-----------TLIIQNMVS-VLREEGQWKFPHEFNPE------NF--LND--QG--EFI------K--PEAFMPFSAG-----------PRMCLGEGLAR-MELFIIMVTLLRKFKFT----WPED--AGQPDLSPVF--------G--ATLTPK----PYCM--K--V-----QLRSE- Kryptolebias_marmoratus_CYP2X27 ------NFPPG------------P-FTLPVLGNL----------LHL-------DNP------L-ENLEKLRK-----SYGNV--FSLFIGPRPTVV-INGLKAMKEAIVV--KA---ADFSGRPQDLLVN-VV--SQR--KG--VVLADYGPS-WREHRRFALMTLRNFGLGK-------KSMEDRIHDELQYTIKILENS-----------IGS--T-----LSPRVMFHNTASNIICQVLFGKRYE----YDDDV------IKTII----WSFNELAKMANGLWALVY--DSFPLCRN--LPLP----FRRAFKIY--GSCQDIAMRLIDEHKKSRVPNEP----------------R-----DFLDC-Y---LDEL-----------------DKRGDD----------------------------GSSFSEERLSNYILDLRFAGTDTTSNTLLTGFLYLIHHPHVQERCQQEIDRV--LQG--------------------------------------------------------------KDR-----------VSYED-RNDMPYVQAVTHEMQ-RVANTAPLSVFHSTTKDTEL-MG--YSIPK------G-----------TMIIQNLTS-VLKEEGQWKFPHEFNPE------NF--LNE--QG--DFV------K--PEAFMPFSAG-----------PRMCLGEGLAR-MELFLITVTLLRKFRFL----WPED--AGEPDYTPIF--------G--ATLSPK----PYNM--K--V-----QLRS-- Kryptolebias_marmoratus_CYP2X25 ------NFPPG------------P-PTLPVLGNL----------RYL-----TSKNP------L-KDLEKLRQ-----SYGDV--YSLFLGSKPAVL-ISGLKAMKEAMVV--KA---TDFAGRPQDLLIG-DL--TQR--KG--VILVDYGSL-WRDHRRFALMTLRNFGLGK-------KSMEERIHEEIQFTVKTLEKS-----------VGK--T-----LSPQVMFHNAASNIICKVLFGTRYE----YDDET------LRVIV----RCFTEVNRIANGPWAMLY--DSVPSVRR--LPLP----FNKAFKNM--EVLLSLSARFVSEHKKSRIPGKP----------------R-----DFVDC-Y---LDEL-----------------DKN-----------------------------KEDSSFSEDQLRSMNFDLYLAGTDTTSTTLLTGFLYLMNFPHIQERCQQEIDVV--LEG--------------------------------------------------------------KDR-----------ATFED-RHSMPYMQAVIHEMQ-RVANILPLSSYHCTTKDTEL-MG--YSIPR------G-----------TMIIQNLTS-VLKEEGQWKFPHEFNPE------NF--LNE--QG--DFV------K--PEAFMPFSAG-----------PRICPGEGLAR-MELFLITVTLLRKFRFL----WPED--AGEPDFTPIF--------G--ATLSPK----PYNM--K--V-----QLRS-- Kryptolebias_marmoratus_CYP2X26 ------NFPPG------------P-PTLPVLGNL----------RYL-----TSKNP------L-KDLEKLRQ-----SYGDV--YSLFLGSKPAVL-ISGLKAMKEAMVV--KA---TDFAGRPQKLFVN-DV--TRH--KG--VILVDYGSL-WRDHRRFALMTLRNFGLGK-------KSMEERIHEEIQFTVKTLEKS-----------VGK--T-----LSPQVMFHNAASNIICKVLFGTRYE----YDDET------LKMIV----QCFTELTTLANGPWAMVY--DSVPFVSY--LPLP----FKKAFRNM--EMFMEFSIRVVKEHKKSRVPGEP----------------R-----DFVDC-Y---LDEL-----------------DKQDKQ----------------------------DSTFSEDQLKSMNFDLYIAGTDTTSNTLLVGFLYLLNFPHVQERCQQEIDTV--LEG--------------------------------------------------------------RDQ-----------VTFED-RHNMPYVQAVIHEMQ-RVANILPLSVFHCTTKDTEL-MG--YSIPR------G-----------TIMIQNLTS-VLKEEGQWKFPHEFNPE------NF--LNE--QG--DFV------K--PEAFMPFSAG-----------PRMCLGEGLAR-MELFLITVTLLRKFRFI----WPED--AGEPDFNLVF--------G--AILTPK----PYNMKGR--A-----EVQAV- Oryzias_latipes_CYP2X14 ------NFPPG------------P-PVLPMLGNL----------LHL-----SLDNP------L-KDFDRLRN-----SYGNV--YSLFLGPKPAVI-INGFKAMKEAMVI--KA---TDFAGRPQDLFVN-DV--SKR--KG--VILADYGES-WRDHRRFALMTLRNFGLGK-------KSMEERISEEIQHTIKTLENN-----------IGK--L-----FSPQIMFHNAASNIICQVLFGKRFE----YDDEI------IKTIV----QCFTRNSKIANGPWAMIY--DSIPLIRK--LPLP----FREAFKNA--EICVDVGTHLVNEHKETRIPGKP----------------R-----DFVDC-Y---LDEM-----------------EKRGDD-----------------------------SSFSEDQLIIYALDLHFAGTDTTSNTLLTGFFYLINYPHIQDKCQQEIDRV--L-E--------------------------------------------------------------EKQ----------QVTFED-RHNMPYMQAVIHEVQ-RIANTVPLSVFHSTTKETEL-MG--YTIPK------G-----------TMIIQNMGS-VLREDGQWKFPHDFNPE------NF--LNE--KG--EFV------K--PEAFMPFSAG-----------PRMCLGEGLAR-MELFIIMVTLLRKFKFT----WPED--AGEPDFTPVY--------G--VTLTPK----PYFM--K--V-----QLRSK- Kryptolebias_marmoratus_CYP2X24 ------NFPPG------------P-PTLPVLGNL----------LNL-----NLENP------L-QDFERLRK-----SYGNV--YSLFIGPKPAVI-INGLKVMKEAMVI--KA---TDFAGRPQDLFIN-DI--TQR--KG--VILADYGEN-WKEHRRFALMTLRNFGLGK-------QSMEDRIHDEICYTVKTLEKN-----------VGE--T-----FSPQVMFHNAGSNIICQILFGKRYE----YDDDI------IKVIV----QCFTENARLGNGLWAMLY--DSLPPIRY--LPLP----FKKAFKNA--EICENLIFNLVEEFKKTRVPGEP----------------R-----HFVDC-Y---LDEL-----------------DKRSGE----------------------------DSSFSEDRLPLYSLDLHFAGTDTTSNTLLTAFLYLMNFPHVQERCQQEIDQV--LDG--------------------------------------------------------------KDR-----------VSFED-RHNMPYVQAVIHEVL-RVANTVPLSVFHCTTKDTEL-ME--YTIPR------G-----------TMIIQNLMS-VLREEGQWKFPHEFNPE------NF--LNE--QG--DFV------K--PEAFMPFSAG-----------PRMCLGEGLAR-MELFLITVTLLRKFRFV----WPED--AGEPDFSPAY--------G--ITLCPK----PYNM--K--V-----ELR--- Danio_rerio_CYP2AA12 ------RFPPG------------P-TPLPFVGTI----------PHF-----LKDSM--------GFIRSLSQ------YGEM--TTVYLGRKPAMV-LNTLQVIKEAIVQ--NG---TSSSGRPSIPILT-WI--TEG--YG--IVLATFGHS-WRQQRRFALHTLRNFGLGK-------KSVEERVTEESGYLVPEMLKL-----------EGK--P-----FDPQHAIQNAVSNIICSIVFGDRFE----YDNKR------FEYLL----EIIKENINQAGSLIGQVF--NLIPIIKH--FPGP----HQKIYQNA--EELKSFIRESTKSHRETLDPDSP----------------R-----DFIDA-Y---LLEM-----------------EKQKSS---------------------------QDSSFHEDNMVMSVADLFLAGSDTTATTIRWGLIYLTQNPDVQERCHEEIVRV--L-G--------------------------------------------------------------YDR----------LPCMDD-RDRLPYTLATVHELQ-RCGNIVPSSVPHETTQPMKL-RG--YDIPQ------G-----------TQMLINLSD-ILANKEHWKHPDTFNPE------NF--LDD--KG--HFY------R--PEAFLPFSLG-----------PRVCLGETLAK-TELFLFITSLLQRIRFS----WPTG--EKWPNMDGIV--------S--VVRSPE----PFKI-IC--------HSRGS- Danio_rerio_CYP2AA11 ------RYPPG------------P-TPLPFVGTI----------PHF-----LKNPM--------GFIRSLSQ------YGEM--TTVYLGRKPAII-LNALQLMKEAFVQ--NG---SSFSGRPPVPVLT-WV--NQG--YG--IIMAMDGHS-WRQQRRFALHTLRNFGLGK-------KSVEERVTEESGYLISELLRV-----------EGK--P-----FNPQHAIHNAAANIICSIVFGDRFD----YDNKS------FTYLL----EIIKENLDLAGSFAGQMV--NLVPIIKN--LPGP----HQKIYQNG--EEFKSFIRESVKAHRETLDPDSP----------------R-----DFIDA-Y---LLEM-----------------EKQKST---------------------------QDSTFHEDNMVMSVGDLFFAGTDTTATTIRWGLLYLTQNPDVQERCHDEIVQV--L-G--------------------------------------------------------------FDC----------FPSMDD-RDQLPYTLATVHEIQ-RCANVAPSGVPHQTTKPIKL-RG--YDIPQ------G-----------TQILINLMG-ILANKEHWKHPDTFNPE------NF--LDD--KG--HFF------K--PEAFLPFSLG-----------PRACLGETLAK-TELFLFVTSLLQRIRFS----WPTG--EKWPDMNRIL--------S--VIRSPE----PFNI-IC--------YSRDS- Danio_rerio_CYP2AA6 ------RFPPG------------P-TPLPFVGSI----------PHF-----LNNPM--------GFIKSLSQ------YGEM--TTVYPGRKPAII-LNTLQLMKEALVQ--NG---SSFSGRPPVPVFN-WV--TDG--YG--IVMATFGHS-WRQQRRFALHTLRNFGLGK-------KSVEERVTEESGYLISEFLKA-----------EGK--P-----FNPQHAIHNAAANIICSIVFGDRFD----YDNKS------FTYLL----EIIKENIIQAGSLVGQVF--NLVPIIKH--VPGP----HQKIYQNG--QAFKSFIRESVKEHRQTLDPDSP----------------R-----DFIDA-Y---LLEM-----------------EKQKST---------------------------QDSTFHEDNMVMAVGDLFLAGSDTTATTIRWGLIYLTQNPDVQERCHEEIVRV--L-G--------------------------------------------------------------FDR----------LPSMDD-RDRLPYTHATVHEFQ-RCANLVPTGVPHQTTQATKL-RG--YDIPQ------G-----------TQILINLTE-ILTNKEHWKHPDTFNPE------NF--LDD--KG--HFF------K--PEAFLPFSLG-----------PRACLGETLAK-AELFLFVTSLLQRIRFS----WPTG--EKLPDMNGIF--------G--IVRSPK----PFNI-IC--------HSRGS- Danio_rerio_CYP2AA8 --------------------------HLPFVGNL----------PVF-----LKNPM--------EFIRSLSQ------YGEM--TTIYLGRKPTIM-LNTVQLAKEVLIQ-------DAFAGKPSLPVLD-WV--SNG--LG--IVMVTFNHS-WRQQRRFALHTLRNFGLGR-------KSVESRVLEESQYLIAELLKK-----------KGK--S-----VNPQHALQNAFSNVICSIVFGDRFD----YDDKR------FEHFL----EILGKSMILTGSTAGQIF--NFAPIIKH--FPGP----HQKIKKNA--DELSGFFQHEVKEHKKTLDPGSP----------------R-----DYIDA-Y---LLEM-----------------EKQKSN---------------------------KDSTFHDENLIGSTTDLFVAGSDSTATTFRWGLLFLIQNPDVQERCHKEIVQV--L-G--------------------------------------------------------------YDR----------LPSMED-RDRLPYTLATVYEIQ-RCANLAPFGLIHETIQPTKL-QG--YDLPR------G-----------TTIIVNLTA-IFSNKENWKHPDTFNPE------NF--LDE--SG--QFS------K--HESFIPFSLG-----------VRVCLGETLAR-TELFLFITALLQRIRFS----LPPD--AKPMDMDGIL--------S--VLRYPQ----NFSF-IC--------CSRDT- Danio_rerio_CYP2AA9 ------RFPPG------------P-TPLPFVGNL----------PHL-----LKKPM--------EFIRSLSQ------YGEM--TTMYLGRKPAIV-LNTYQVAKEALVQ-------EAFAGRPHLPIIE-WI--TKG--LG--IVMVTFNNS-WKQQRRFAQHTLRNFGLGK-------KSLESRVLEESQYLIAEMLKD-----------EGR--P-----MNPQHAVQNALSNIICSIVFGDRFD----YNNKR------FEYLL----KILNESIILTGSAAGQIF--NFAPIIKH--FPGP----HQMINENA--NEVYSFVRHEVEEHRKTLDPGSP----------------R-----DFIDG-Y---LLEI-----------------EKQKSN---------------------------KDSTFHEDNLITTTVDLFLAGSDSTSSSIRWGLLFLIQNPDVQERCHEEIVQV--L-G--------------------------------------------------------------YDR----------LPCMDD-RDRLPYTLATVHEIQ-RCGNIAPFGLFHETAQPTKL-RG--YNIPQ------G-----------TIIMTNYTA-IFSNKEHWKHPDTFNPE------NF--LDE--NG--HFS------K--PKCFIAFGVG-----------PRICLGDTLAK-TALFLFITSLLQRIRFS----LPPD--AKPMDMDGIL--------S--IIRYPE----TFCI-IC--------CSRDT- Danio_rerio_CYP2AA3 ------RTPPG------------P-TPLPFVGTI----------PHF------LKNP--------LGFIRSMS-----QYGDM--STMYLGRKPAIF-LNTIQLAKETLVQ-------DTFSGKPYLPVIE-WI--SKG--FG--IAMVTFNHS-WRQQRRFALHTLKNFGLGK-------KSVEDRVLEESRYLIAEMLKD-----------EGK--P-----VDPHHPIQNAVSNIICSIVFGDRFE----YNNKR------FEYLL----KMLNETIMLAGSASGRIF--NLVPFIKH--FPGP----HQKIKKNT--DDLLIFLGDEVEEHRKTLDPGSP----------------R-----DFIDA-Y---LLEI-----------------EKQKFN---------------------------KDSTFHEGNLLASAGDLFMAGTDTTETTIRWGLLFLIQNPDVQERCHEEIVQV--L-G--------------------------------------------------------------YDR----------LPSMDD-RDRLPYTLATVHEIQ-RYGNIIP-ILIHETILPTKL-QG--YSIPQ------G-----------TTIVTNIQA-IFSSKDHWKHPDSFNPE------NF--LED-----RHFI------K--PESFIMFSLG-----------PRSCLGEILAR-TELFLFITSLLQRIHFS----WPPD--AKPIDMDGIF--------G--LVHSPQ----AFNV-IC--------RSRDT- Danio_rerio_CYP2AA4 ------RFPPG------------P-TPLPFVGNL----------PHL------LRDP--------MGFNRLMA-----QYGEM--STMYLGKKPAIV-LNTIQVAKEALVQ-------EAFAGRPCLPVID-WT--SNG--CG--IIMATFNNS-WKQQRRFALHTLRNFGLGK-------KSIESRVLEESQYLFAELLKD-----------EGE--P-----VNPHHALQNAVSNIFCSIMFGERFD----YDNKR------LGYLL----KILNENMMLTGSAIGQIF--NLAPFIKH--FPGP----HQKIKKNS--NELYSFIEDEVEEHRKTLDPVSP----------------R-----DFIDA-Y---LLEI-----------------EKQKSN---------------------------KDSTFQEENLIGSAIDLFFAGTDSTATSIRWGLLFLIQNPDVQERCHEEIVQV--L-G--------------------------------------------------------------YDR----------LPCMDD-CDRLPYTHATVHEIQ-RFAKTVPFGVFHETIWPTKL-HG--FDIPQ------G-----------TMIMTNLAA-IFSSKEHWKHPDTFNPE------NF--LDE--NG--HFS------K--PESYIPFSLG-----------LRACIGESLVR-TELFLFATVLLQRIHFS----WPPD--AKPLDMDGIV--------G--IVRYPQ----TFSI-IC--------CSRDS- Danio_rerio_CYP2AA7 ------RFPPG------------P-TPLPFVGNL-----------PH-----SLKNP--------MEFIRSMP-----QYGEM--TTMYLGRRPAIV-LNTIQLAKEAFVQ-------DAFSGRPFLPVMD-WV--ANG--LG--IIMVTFNHS-WRQQRRFALHTLRNFGLGK-------KSVEDRVLEESRYLIAEILKG-----------EGK--P-----MSPHHPIQNAVSNIICSIVFGDRFD----YDNKR------FEYLL----ELLNENFVLTGSAAGQIF--NLAPFIKH--FPGP----HQKIKQNA--NELLAFIQGEVKEHKKTLDPDSP----------------R-----DFIDA-Y---LLEI-----------------EKQKSN---------------------------KDSTFHEGNLAISTADLFLAGTDTTSTTIRWGLLFLTQNPDVQERCHEEIVQV--L-G--------------------------------------------------------------YDR----------LPSMDD-RDKLPYTLATVHEIQ-RCANLVPFGVIHETIQPTKL-RG--YDIPQ------G-----------TVVMTNLAA-ILSDKEHWKHPDTFNPE------NF--LDE--NR--QFS------K--PESFIPFSLG-----------LRFCLGETLAK-MELFLFITSLLQRIHFS----SPPD--AKPIDMDGVV--------G--IVRYPQ----PFSI-IC--------CSRDT- Danio_rerio_CYP2AA1 ------RFPPG------------P-TPLPFVGNL----------PHF------LKSP--------MEFIRFMP-----QYGEM--TTIFFGRKPVIM-LNTIQLAKEAYVQ-------DVFSGRPAIPLFD-WI--TNG--LG--IVMVTFNNS-WRQQRRFALHTLRNFGLGK-------KTVEDRVLEESRYLIAEMLKE-----------EGK--S-----MNPQHALQNAISNIICSIVFGDRFE----YDNKR------FEYLL----KTLNENIMLAGSAAGQIF--NLVPFIKH--FPGP----HQKIKQNA--DELLGFIRDEAKEHRQTLDPDSP----------------R-----DFIDA-Y---LLEI-----------------EKQKSS---------------------------KDSTFHEENLVVSASDLFLAGTDTTETTIRWGLINLIQNPDVQERCHEEIVRV--L-G--------------------------------------------------------------YDR----------LPSMDD-RDKLPYTLATVYEIQ-RCANIAP-NVMHQTILPTKL-HG--YNIPQ------G-----------TIILTNLAA-IFSNKEHWKHPDAFNPE------NF--LDE--NG--HFS------K--PESFIPFSLG-----------PRVCLGETLAR-TELFLFITALLQRIRFS----WPPD--AKPIDMDGIM--------G--LVRSPQ----TFNV-VC--------HSRDN- Danio_rerio_CYP2AA2 ------RFPPG------------P-TPLPFVGNL----------PHL-----LKNPM--------GFKRSLSE------YGGL--ATVFIGRQPAIS-INTIQLAKEALVQ-------DVFSGRPPLPIFD-WI--SHG--LG--IIMVTFNHS-WRQQRRFALHTLRNFGLGK-------KTVEDRVLEESQYLIAEMLKD-----------EGK--S-----MNPQHALQNAVSNIICSIVFGDRFE----YDNKR------FEYLL----KILNENIMLTGSAAGQIF--NLVPFIKH--FPGP----HQKVKQNA--DDLFNFIRDEAKEHKQTLDPDSP----------------R-----DFIDA-Y---LLEI-----------------EKQKSS---------------------------KESTFHEEHLVVSTSDLFLAGTDTTETTIRWGLIYLIQNPDVQERCHEEIVQV--L-G--------------------------------------------------------------YDR----------LPSMDD-RDKLPYTLATVHEIQ-RCGNIAP-KLLHETIRRTKL-HG--YDIPQ------G-----------TTIIANFTA-MFSDKELWKHPDAFNPE------NF--LDE--NG--QFS------K--PEYFFPFSLG-----------PRACLGEALAR-TELFLFITSLLQRIRFS----WPPN--AKPIDMDGIV--------G--IVRSPE----PFNI-IC--------HSRDT- Danio_rerio_CYP2R1 ------GFPPG------------P-TPLPIIGNM----------LSL------ATEP------H-VYMKRQSD-----IHGQI--FSLDLGGIPTVI-LNGYDAIKECLYH--QS---EVFADRPSLPLFQ-KM--TKM--GG--LLNCKYGRG-WIEHHKLAVNCFRYFGTGQ-------RMFE-RISEECLYFLDAIDQH-----------QGK--P-----FNPKHLVTNAVSNITNLIIFGQRFT----YDDGD------FQHMI----EIFSENVELAASSWAFLY--NAFPWMEY--LPFG---KHQRLFRNA--NEVYKFLLQIIRRFSQGRVPQSP----------------Q-----HYIDA-Y---LDEM-----------------EQSTPD---------------------------KATSFSQDNLIFSVGELIIAGTETTTNCLRWAMLYMALYPRIQEKVQMEIDSV--L----------------------------------------------------------------NGR----------QPAFED-RQRMPYVEAVLHEVL-RLCNIVPLGIFRATSQDAVV-RG--YTIPK------G-----------TMVITNLYS-VHFDEKYWSDPSIFCPE------RF--LDC--NG--KFI------R--HEAFLPFSIG-----------KRHCLGEQLAR-LEMFLFFTTLLQRFHLQ----FSEG---FIPSLSAKL--------G--MTLQPQ----PYSI--C--A-----IRRQQ- Kryptolebias_marmoratus_CYP2R1 ------GFPPG------------P-SPIPVIGNI----------FSL------ATEP------H-VFLKKQSE-----VHGRI--FSLDLGGIMTVV-LNGYDCIKECLYH--QS---EMFADRPSLPLFK-KM--TKM--GG--LLNCKYGKG-WIEHRKLACNSFRYYGSSQ-------RLFERRITEECMFFVDAIDKY-----------KGK--P-----FNPKHLVTNAVSNITNLIIFGQRFT----YDDRN------FQHMI----ELFSENVELAVSGWALLY--NAFPWIEY--LPFG---KHQKLFRNA--AEVYNFLQEVINTYSQGRVKHEP----------------R-----HYIDA-Y---LDEL-----------------EQSTGN---------------------------PNSSFSYENLIYSVGELIIAGTETTTNTLRWAALYMAMYPNIQERVHREIDSV--L-S--------------------------------------------------------------NGR----------PPSMED-KHRMPYVEAVLHEVL-RFCNIVPLGIFRATSQDATV-NG--YTIPK------G-----------TMVITNLYS-VHFDEKYWNDPSVFSPE------RF--LDS--SG--NFV------R--REAFLPFSLG-----------RRHCVGEQLAR-MEMFLFFTTLLQRFHLQ----FPPG---TVPTVTPKL--------G--MTLQPK----PYSI--C--A-----VRRQQ- 'Takifugu rubripes CYP2K-like2' ------KDLPG------------P-EALPLLGNL----------HQL-----DLKRL------D-CHLVQLSQ-----KYGPI--FRVYLASKKVVV-LAGYTAVKQALVN--QA---EDFGEREIFPIFH-DF--NKG--NG---ILFTNGDQ-WKEMRRFALMTLKDFGMGK--------KIEEKIIKECQYLIEAFEQH-----------QGE--A-----FSNAQVISYATSNIISAIMYGRRFD----YKDPT------FQAMI----ERDHEVIHLTGSPSIQIY--NIFPWLGP--FLKT----WRYIMKKV--EINIESTRRIIGEMKETRNPGTC----------------R-----CFVDA-F---LIHK-----------------ENQEES------------------------D-VNAHYYHEDNLLHCAMNLFGAGTDTTATTLQWGLLYITKYPHIQDGVQEELRRV--V-G---------------------------------------------------------------NR----------QVRVED-RKNLPYMEAVIHETQ-RMANIVPMSLPHRTSRDRHL-LG--SICPQ------G-----------TMVIPLLTS-VLYDESQWEKPHTFNPA------HF--LDD--EG--RFV------R--RDAFMPFSAG-----------RRMCLGEGLAR-MELFLFFASLLQHFRFK----PAPGVSEDSLDLTPVV--------G--ITLNPL----THKL--R--A-----ISRF-- Oryzias_latipes_CYP2K28 ------REPPG------------P-RPLPLLGNL----------FQV-----DLKRL------D-QSLFDLSK-----KYGPV--FVVNFGPKKVVV-LAGYRTVKQALVN--QA---KEFGNREVTPIFY-DF--NKE--HG---ILFANGES-WNEMRRFALSTLRDFGMGK-------RISEQNIIEECRWLIEELEKL-----------QGK--P-----FDNTHTISYAVSNVLSGLMFGKRFD----YQDPL------LQAIV----DRDNEIIYLTGTVSILLY--NMFPWLGP--WLKN----WKTLMKNM--EAAKTDMKKIIAELKDTLDPDTR----------------R-----CFVDA-F---LTQK-----------------QNLKEV---------------------------NGSHYHDDNLLYTVMNLFAAGTDTTATTIEWCLLFMAKYPHIQERVQEELNWV--V-G---------------------------------------------------------------SR----------QVRIED-RKNLPFTDAVIHESQ-RLANIAPMAIPHTTSKDVTF-QG--YFIKK------G-----------TTVLPLLTS-VLYDESEWESPRTFNPS------HF--LDK--EG--KFL------K--RGAFMPFSAG-----------RRVCLGESLAR-MDIFLFFTSLLQHFSFT----PPPGVSEDELDLTPVV--------G--FTLSPQ----PQGL--C--A-----VRRQ-- Kryptolebias_marmoratus_CYP2K42 ------PEPPG------------P-RPLPVLGNL----------FQV-----DLKTI------H-HSLFILSK-----KYGSV--FQVRLGPKKVVV-LAGYRTVKEALVN--QA---EAFRNIEITPLFH-DI--NQG--HG---IILANGDS-WKEMRRFALTTLKDFGMGR-------KMSEEIIIEECGYLIKEFEQF-----------EGK--A-----FSNTQVISYATSNVISALVFGKRFD----YKDPF------LNIMM----ERNYENIRLMSSASIQIY--NVIPWIGP--LLKN----WRDFKKNI--GNSLADIKKIIVDLKKTLDPEVC----------------R-----CFVDA-F---LIHK-----------------KQLEDS------------------------E-NRNSHYHDNNLLYSVMNLFGAGTETTATTLKWGLLYLVKFPHIQDRVQEELSRV--V-G---------------------------------------------------------------SR----------QVRIED-RKNLPYTDAVIHEIQ-RVANVAP-VLPHTTTKDVTL-QG--YFLKE------G-----------TTVLLLLLS-VLSDESEWESPHSFNPS------HF--LDD--EG--KFI------R--RDAFMPFSTG-----------PRACLGESLAR-MELFLFFASLLQHFRFT----LPPGVSEDELDLKPVE--------G--FTLGPK----PQQL--C--A-----VQRQ-- Kryptolebias_marmoratus_CYP2K39 ------REPPG------------P-RPLPVFGNL----------FQV-----DLKRP------D-QSLFNLSK-----KYGPV--FQIYLGLKKVVV-LAGYRTVKQALVN--QA---EEFGNIDISPIIY-DF--NQG--HG---IALANGDS-WKEMKRFALTTLRDFGMGK-------KMSEDLIIEECGYLIKEFEQL-----------EGE--T-----FDRSQTIDYASSNVVSALTFGKRFD----YEDPI------FQTMV----ERNHETLCLIGSASIQLY--NLIPWLGP--FLKN----WRDFMKNM--EDMKADIRKLITDLKETLDPEVC----------------R-----CFIDA-F---LIRK-----------------KHLEDS------------------------D-IIDSHYHDENLLFSVINFFGAGTETTATTLKWSLLYMAKFPHIQDRVQEELSRV--V-G---------------------------------------------------------------SC----------QIQIDD-RKNLPYTNAVIHETQ-RFANIGPFSVPHATTKDVTL-QG--YFIKK------G-----------TTVLTLLTS-VLYDENEWESPHSFNPS------HF--LDD--EG--KFI------R--RDAFMPFSAG-----------RRACLGESHAK-MELFLFFASLLQNFHFI----PPPGVSEDDLDLKPVL--------G--CTLNPK----PQQL--C--A-----VLRR-- Kryptolebias_marmoratus_CYP2K52 ------PEPPG------------P-RPLPVFGNL----------FQV-----DLKRL------D-QSLFNLSK-----TYGPV--FQVYFGPKKVVV-LAGYRTVKEALLN--QA---DEFGNREITPIFY-DF--SEG--HG---IVFSNGDS-WKEMRRFALSTLKDFGMGR-------KMSEEIIIEECGYLIKEMEQY-----------GGE--S-----FNNTQAISYTASNVISALMFAKRFE----YKDPV------FQSMV----EKDKQNIHLAGSASIMIY--NFIPWLGP-LLKNR-----RTMLKNF--IDGRADIWRKIEELKETLDPEVC----------------R-----CLVDA-F---LIRK-----------------KQLEDS------------------------K-IKNSHYHDNNLLYSIQGLFVAGTDTTATTLKWGLLYLTKFPHIQDRIQEKLSRV--V-G---------------------------------------------------------------SC----------QVRIED-RKNLPYTDAVIHETQ-RFANIGPLALPHTTTKDVTL-QG--YFIKK------G-----------TTVLTVLTS-VLYDENEWESPHSFNPS------HF--LDD--EG--KFI------R--RDAFMPFSAG-----------TLLDLGISL---------------------------------------------------------------------------------- Kryptolebias_marmoratus_CYP2K43 ------PEPPG------------P-RPLPVFGNL----------FQV-----DLKRL------D-QSLFNLSK-----KYGPV--FQVYFGPKKVVV-LAGYRTVKEALVN--QA---DEFGDRDICPLFY-DL--NQE--YG---ILFSNGDS-WKEMRRFALSALRDFGMGR-------KMSEEIIIEECGYLIKEFEQF-----------EGE--A-----FDNTQAINYATSNVISALMFGKRFE----YKDPV------FQTMV----ERDNETIHLMGTASLVIY--NMIPWMGP--FLKN----WTDLMKNM--ENNKADIRKIIADLKQTLDPETC----------------R-----CFIDA-F---LIRK-----------------NQLEDL------------------------E-MKSSHYRDENLLYSVINLFAAGTDTTATTLKWSLLYMVRFPQIQDRVQEELSRV--V-G---------------------------------------------------------------SR----------QVRIED-RKNLPYTDAVIHEIQ-RLANIVPMALPHATSKDITL-QG--HLIKE------G-----------TTVFPLLTS-VLYDESEWESPHSFNPS------HF--LDD--EG--KFI------R--RDAFMPFSAG-----------RRACLGESLAK-MELFLFFASLLQHFQFT----PPPEVSEDELDLKPVV--------G--LTLAPK----PQKL--C--A-----VCRL-- Kryptolebias_marmoratus_CYP2K40 ------PEPLG------------P-RPLPVFGNL----------FQV-----DLKRL------D-QSLFNLSK-----TYGPV--FQVYFGPKKVVV-LAGYRTVKEALLN--QA---EEFGNREITPLFY-DF--NQG--HG---IVFSNGDS-WKEMRRFALTTLRDFGMGK-------KMSEEIIIEECGYLIKEMEQY-----------GGE--A-----FNNTQAINYAASNVISALMFKKRFE----YKDPV------FQTMV----EKDNETIRLTGSVSIMIY--NLCPWLGP--FLKN----WRDMMKNI--EANKAHLRKLISDLKETLDPEIC----------------R-----CFVDA-F---LIQK-----------------KHLKDF------------------------D-EKSSHYHDENLLYSVMNLFAAGTDTTATTLKWGLLYMAKFPHIQDRVQEELSRV--V-G---------------------------------------------------------------SR----------QIQTED-RKNLPYTDAVIHETQ-RFANIGPLAIPHKTTRNVTF-QG--YFIKK------D-----------TTVFPLLTS-VLYDENEWESPHSFNPS------HF--LDD--EG--KFI------R--RDAFMPFSAG-----------RRACLGESLAK-MELFLFFTSLLQRFHFT----PPPGVPEDELDLKPVV--------G--MTLAPK----PQQL--C--A-----VRRR-- Kryptolebias_marmoratus_CYP2K41 ------PEPPG------------P-RPLPVFGNL----------FQV-----DLKRL------D-QSLFNLSK-----TYGPV--FQVYFGPKKVVV-LAGYRTVKEALLN--QA---DEFGNREITPILN-DL--TQG--HG---ILFSNGDS-WKEMRRFALSTLRDFGMGR-------KMSEEIIIEECGYLIKEMEQY-----------GGE--A-----FNNTQAINYAASNVISALMFGKRFE----YKDPV------FQNMV----ERDNETIHLMGTASIMMY--DLFPWLGP--FFKN----WRNLMKNN--EDSLADLKKLIADLKETLDPEIC----------------R-----CFVDA-F---LIRK-----------------KHLKDD------------------------E-VKNSHYHDENLLYTVDDLFAAGTDTTATTLKWGLLYMAKFPHIQRCVQEELSRV--V-G---------------------------------------------------------------SR----------QVRIED-RKNLPYTDAVIHEIQ-RFANIAPMALPHTTSNDLTF-QG--YVVKE------G-----------TTVFPLLTS-VLYDESEWESPHSFNPP------HF--LND--EG--KFI------R--RDAFMPFSAG-----------RRACLGESLAK-MELFLFFASLLQHFHFT----PPPGVSEDEVDLKPVV--------G--LTLTPK----PQRL--C--A-----VHRL-- Kryptolebias_marmoratus_CYP2K46 ------QEPPG------------P-RPVPLFGNL----------FQM-----DLRRL------N-QSLFDLSK-----KYGPV--FQVYFGSQKVVV-LSGYRTVKQALVN--HA---NEFGDREITPAFF-DL--TKG--FG---VVFSNGDL-WKEMRRFALTTLRDFGMGK-------KRSEDIIVEECQYVINEFEQL-----------EGK--P-----FDNTKFFNYAATNIVSVLMFGKRFD----YKDQV------FRAMV----ERDNELIRLLGTASISVY--NCFPWLGP--FLKD----WRDYIKHV--KASREDVKQIIADMKETLDPEVC----------------R-----CFVDA-F---LIRK-----------------KQLEES---------------------------ENSHFNDDNLLYSVINLIEAGNDTTATTLKWSLLYMAKYPHVQDRVQEELSRV--V-G---------------------------------------------------------------SR----------QVQSED-RKNLPYTDAVIHETQ-RFADLVPLALPHTTCQDVTL-QG--YFIKK------G-----------TTVFPLLTS-VLYDENEWESPHSFNPS------HF--LDD--EG--KFI------R--RDAFMPFSAG-----------RRACLGEGLAR-MELFLVFTSLLQRFCFT----PPPGVSGDEVDLTPVV--------G--LTLSPR----PQKL--C--A-----VQRN-- Kryptolebias_marmoratus_CYP2K44 ------PEPPG------------P-RPLPLFGNL----------FQV-----DLKWL------D-KSLFELSK-----KYGPV--FQVYFGPKKVVV-LAGYKAVKQALVN--QA---VEFGNRDITPAFY-DL--TKS--HG---IIFSNGDS-WKEMRRFALTALRDFGMGK-------KMSEEIIIEECHYLIEELEQF-----------EGK--A-----FENTKPFNYAASNVISALIFGRRFD----YKDAI------FQAMV----RRENEIIRLTGSASVWIY--NAFPWLAP--LLKN----WRDLIKNV--KGNETDAMKLIADLKESLDPEVC----------------R-----CYVEA-F---LIHK-----------------KQLEDS------------------------E-MKNLYYHDENLLYCVTNLLEAGNDTTANTVKWGLLHMAKNPHVQDRVQEELSRV--V-G---------------------------------------------------------------SR----------QIRTED-RKNLPYTDAVIHEIQ-RLANIFPLALPHATSTDVTF-QG--YFIKQ------G-----------TTVFPLLTS-VLYDESEWESPHSFNPS------HF--LDK--EG--NFI------K--RDALMPFSAG-----------RRACLGESLAK-MEVFLFFTSLLQHFHFT----PPPGVSEDEVDLTPAV--------G--FSLCPR----PQKL--C--A-----VRRK-- Kryptolebias_marmoratus_CYP2K45 ------REPPG------------P-RPLPVFGNL----------FQV-----DLKWL------D-KSLFKLSK-----KYGPV--FQVYFGPKKVVV-LAGYRTVKQALVN--HA---VEFGTREITPTFN-DL--HKG--HG---IAFSNGDS-WKEMRRFALTTLRDFGMGK-------KMSEKIIAKECCYLIEEFEEF-----------EGK--A-----FNNTKPINYAATNVISSLMFGKRFD----NKDQV------FQAMV----ERDNEIVRLSGTASLWLY--NIFPWLGP--FFKN----WRDFMKIL--EDNEKTVKKIIADLKETLDPEVC----------------R-----CFVDA-F---LIRQ-----------------KHLEDS------------------------E-ITNLHYHDDNLLYSVMNLFEAGNDTTANTVKWGLLYMAKFPHIQDRVQEELSRV--V-G---------------------------------------------------------------SR----------QVRTED-RKNLPYTDAVIHETQ-RLAKNLPVGLPYTTSKNVTF-QG--YFIRA------G-----------TTVFPLLTS-VLYDESEWESPHSFNPS------HF--LDD--EG--KFI------R--RDAFMPFSAG-----------RRACIGESLAR-MELFLFFASLLQHFRFT----PPPGVSEDEVDLAPVV--------G--FSLCPR----PQKL--C--A-----VRRR-- Kryptolebias_marmoratus_CYP2K51 ------QEPPG------------P-RPVPLFGNL----------FQV-----DLKRL------H-QSLFNLSK-----KYGPV--FQVYFGPRKVVV-LAGYRMIKQALVN--QA---DEFGTRKMIPAFY-DL--SKG--HG---IVFSNGET-WKEMRRFALTTLRDFGMGK-------KMSEKIIIEECGFLIKEFEQF-----------EGK--V-----FNNTKSINYATTNVISALMFGKRFE----YKDQV------FQGMV----ERGNEIIHLVGTASLWIY--NIFPWLGP--FLKN----WRDFMKIL--EDNEKTVNKIIADLKETLDTEVC----------------R-----CFVDA-F---LIRQ-----------------KHLEDS------------------------E-ITNLHYHDENLLYSVTNLLEAGNDTTANTLKWGLLYMAKFPHIQDRVQEELSRV--V-G---------------------------------------------------------------TR----------QIQTED-RKNLPYTDAVIHETQ-RLANILPISLLHATSKDITL-QG--YFIKE------G-----------TAVLPLLTS-VLYDESEWESPHSFNPS------HF--LDD--EG--KFI------R--RDAFMPFSAG-----------RRACLGESLAR-MELFLFFTSLLQRFRFT----PPPGVSGDEVDLTPVV--------G--FTLSPR----PQKL--C--A-----VQRK-- Danio_rerio_CYP2K6 ------KYPPG------------P-KPLPLLGNL----------HIL-----DLKKT------Y-LSLLELSK-----RYGPI--YTVYLGPKKVVI-LSGYKIVKEALVN--LS---EEFGDRDISPIFH-DF--NRG--YG---IAFSNGEN-WREMRRFALSTLRDFGMGR-------KRSEELIIEEIKYVKEEFEKF-----------GGN--P-----FETKLPLALAISNIIASIVFSVRFE----YSNTK------LHRMV----GRAYENMKLTGSPSVQIY--NMFPWLRP-IVANR-----NQIVKNL--KDTFKQNEELINGVMKTLDPFNP----------------R-----GIVDS-F---LIRQ-----------------QKDEES------------------------G-KTDSLYNSNNLYCTVNNLFGAGTDTTVTTLRWGLLLMAKYPEIQAKVQDEIERV--I-G---------------------------------------------------------------GR----------QPVVED-RKNLPYTDAVIHEIQ-RFADISPIGAPRQTTCDVHL-NG--YFIKK------G-----------TPVFPLLVS-VLRDEDEWEMPDSFNPK------HF--LNK--QG--QFV------K--KDAFMPFGAG-----------RRVCIGESLAR-MELFLFFTSLLQYFRFT----PPPGVSEDDLDLTPVV--------G--FTLNPK----PHQL--C--A-----VKRS-- Danio_rerio_CYP2K22 ------KYPPG------------P-KPLPLLGNL----------HIL-----DLKNT------Y-MSLWKLSK-----QYGPV--YTVHMGPRTVVV-LSGYKAVKEALVN--LS---EEFGERDISPIFQ-DF--NEG--YG---IVFSNGEN-WKEMRRFALSNLRDFGMGK-------KRGEELITEEIKYLKEEIERF-----------GGK--P-----FETKLPLAMAISNVIALIVYSIRFE----YNSPK------FHRAI----VRANENAKLVGSPSVQLY--NMFPWLRL--FVIN----QKRVVDNV--QESFKQIGEIVNGLKKTLNPQSP----------------R-----GIADK-F---LIQQ-----------------QKDKES-------------------------GKTDSLYNSNNFLTTINNLFGAGIDTTVTTLRWGLLLIAKYPEIQAKVHDEIDSV--I-G---------------------------------------------------------------ER----------QPVPGD-RKNLPYTDAVIHEIQ-RFADILPIGLLRQTSCDVHL-NG--YLIKK------G-----------TSVFPLIAS-VLRDENEWETPDSFNPK------HF--LNK--QG--QFV------K--KDAFMPFGAG-----------RRLCIGESLAR-MELFLFFTSLLQHFCFT----PPPGVSEDELDLTPVV--------G--FTLSPM----PHKL--C--A-----VKRF-- Danio_rerio_CYP2K31 ------KYPPG------------P-KPLPLLGNL----------HIL-----DLKNT------Y-MSLWKLSK-----TYGPI--YTVHMGPRKVVV-LSGYKTVKEALVN--LS---EEFGDRDISPIFH-DF--NQG--YG---IVFSNGEN-WKEMRRFALSNLRDFGMGR-------KRSEELIIEEIKQLKEEFEKF-----------RGK--P-----FETKMPIAMAIANIIALIVYSIRFE----YTNTK------LHCMI----GRAYENARLTGSPSVQLY--NMFPWLRP--FVAN----QKRIINNV--KEAFKQSGEIMNGLKNTLNPQDP----------------R-----GIADK-F---LIRQ-----------------QMDEDS------------------------G-KTDTYYNSNNLLSTINNLFGAGTDTTVTTLRWGLLIMAKNPEIQAKVQDEIKRV--I-G---------------------------------------------------------------DR----------QPVPDD-RKNLPYTDAVIHEVQ-RFADVLPIGSPHQTTCDVHL-NG--YLIKK------G-----------TSVCPLLAS-VLRDENEWETPDSFNPK------HF--LNK--QG--QFV------K--KDAFMPFGAG-----------RRLCIGESLAR-MELFLFFTSLLQHFCFT----PPPGVSEDELDLTPVV--------G--FTLNPI----PHKL--C--A-----VKRS-- Oryzias_latipes_CYP2K30 ------KEPPG------------P-TPIPILGNL----------HQL-----DLKRP------D-QTFMKFAK-----KYGSV--FTVYMGPKKTVV-LTGYKTMKEALVN--YA---EEFGEREAPTVAK-EA--HLD--CG---VVWANGAS-WREMRRFALSTLRDFGMGK-------RACEDKIIPECHSLLKEIRKF-----------QGE--A-----FDPTLIINSAVCNVICSMVYGTRFE----YDDPD------FRTIL----SRTMKGIQLLGSPGVQLH--NLFPRIGR-LFLSA----SKQINQIF--TANKNYHLKLL---KETFTPHTC----------------K-----SIADA-F---QLRQ------------------QEEDG--------------------------FPNSHFHDANILVTIMNLFTAGTETTAATLRWALLFMAKYPKIQDQVQEELSRV--M-E---------------------------------------------------------------GR----------QVTVED-RQRLPFTDAVIHETQ-RKANIIPLSLLHRTSQDVTF-KG--FFIEK------G-----------TTVIPVLTS-VLYDENEWEKPNIFYPA------HF--LSK--DG--KFL------K--RDAFMPFSAG-----------RRLCLGESLAR-MELFLFFSTLLQHFRIA----PPLGVSEEELDLTPRP--------G--GTLSPQ----PHKL--C--L-----VSLK-- Kryptolebias_marmoratus_CYP2K47 ------PGPPG------------P-RPLPLLGNL----------LQL-----DFKRP------D-KTFVELSK-----KYGSV--FTFYMGLKKAVV-LTGYQTVKEALVN--YA---DEFGERDVPAVAK-EA--NLN--HG---IVWSNGDS-WKEMRRFALTNLKDFGMGK-------KACEDKIIEESQSLVQEFKKF-----------KGE--A-----FSTDRIITCAVSNIICSVIYGSRFE----YEDPA------FQTIT----NRTSIAVKFSASPKIQFY--NLYPGIGK-LFISA----RKKMSDIY--AANKKDHLKLLNNLKETLNPQMC----------------R-----GVADV-F---MVPD-----------------LHLQES------------------------G-ISNSNYTDENLLATVMNLFAAGTETTTTTLRWSLLYMTKYPKIQAKVQEELNTV--V-G---------------------------------------------------------------SR----------QVQVQD-KQNLPFTNAVIHETQ-RLANIVPLALAHRTSQDVTF-QG--HFIEK------G-----------TIVFPVLTT-VLHDESEWEKPYDFHPA------HF--LDK--DG--NFT------K--RDAFLPFSAG-----------RRMCPGESLAK-MELFIFFTTFLQHFRFT----PPPGVSEEDLDLTPLP--------GGTGTLRPQ----PHKL--C--A-----VSLM-- Kryptolebias_marmoratus_CYP2K50 ------HGPPG------------P-KPLPLLGNL----------LQL-----DFKRL------D-RTFVEFSK-----KYGSV--FAIYLGQRKVVI-LAGYQTVKEAFVN--YA---EEFGDRDVPIVAK-DT--NLD--HG---IAWVNGDS-WKEMRRFALTNLKDFGMGK-------KACEDKIIEEFHKLIKEFKKF-----------KGE--A-----FDMAQLMNFAVCNIICSMVYGNRFE----YGDPE------FQTVI----NKTGESLNLLGTPAIKLY--TLFPSLGK-LLFSA----RKKLKTTF--EDNKRHHLTLLNRLRETLNPQMF----------------R-----GVADV-F---IAPD-----------------LHLQES------------------------E-ISTSNYTDENLLAIVINLFAAGTETTLTTLRWGLLFLTKHPKIQAKVQEELNTV--V-G---------------------------------------------------------------SR----------QVQVQD-KQNLPFTNAVIHEIQ-RLANIVPLALAHSTSKDVIF-QG--HFIEK------G-----------TIVFPLLTT-VLHDESEWEKPYDFHPA------HF--LDK--DG--NFT------K--RDAFLPFSAG-----------RRICPGESLAK-MELFIFFTTFLQHFRFT----PPPGVSEEDLDLTALP--------G--GTLRPQ----PHKL--C--A-----VSLK-- Kryptolebias_marmoratus_CYP2K48 ------KEPPG------------P-TPLPLLGNL----------LQL-----DLKKP------H-ETLIEFSK-----KYGSV--FTVHFGPQKVVV-LAGYRTVKEALVN--HD---EAFGVRGPLQIVD-EL--NQG--HG---VLWTNGNT-WREMRRFSLTNLKDFGMGR-------KACEDKIIEECQHLVEVLKNF-----------KGE--A-----FDTNQSLNYAVSNIIASMIYGSRFE----YEDLE------FTSMV----DRINRSGTLLGSPSVQVY--NLYPFLFK-WIANR-----KESHNVA--AANRKQNFALIRHLKQTLNPQMC----------------R-----GFVDA-F---LVHK-----------------KKLEES------------------------G-ISDNEFSDDNLVMTVANLFAAGSETTSSTLRWGLLFMAKFPDIQGKVREELKRA--V-G---------------------------------------------------------------DR----------QVQAAD-RMNLPYTNAVIHETQ-RMANILPESLPHKTSRDITF-HG--HLIRK------G-----------TTVYPLLMS-VLRDANEWEKPDTFYPP------HF--LDK--DG--KFA------K--RDAFMPFSAG-----------HRMCLGESLAR-MELFIFFTTLLQHFRFT----PAPGVLEEDLDLTPRT--------G--LSLTPV----PHKL--C--A-----VSCM-- Takifugu_rubripes_CYP2K1 ------KCPPG------------P-KPLPILGNL----------LQF-----DLKRP------Y-NTLMKLSK-----TYGSV--FTVYLGPKKVVV-LAGYKTVKEALID--HA---EEFGERDPIMLVQ-NA--NHE--HG---VLWSNGES-WKEMRRFALTNLRDFGMGK-------KACENKIIEECSYLMEELKKW-----------KGE--P-----FDTTHPINYAVSNIICSMVYGNRFE----YDDPE------FTSLV----DRTNTLIQISGSPSVLVY--DLFPWIGP--LVNN----KKLFQSLF--AANKKQNLQLFAAAKEMLNPQMC----------------R-----SFVDS-F---LARQ-----------------QILEKS--------------------------GTNVHFHDENLMSTVMNLFNAGTDTTATTLRWGLLLMAKYPLIQDQVQEELRRV--I-G---------------------------------------------------------------SR----------QVQVED-RKSLPFTDAVIHETQ-RLANIVPMALPHKTSQDVTL-QG--FFIEK------G-----------TTVYPLLTS-VLYDETEWEKPLNFYPA------HF--LDK--DG--KFV------K--REAFLPFSAG-----------RRICLGEGLAK-MELFIFFSTLLQHFRFR----PPPGVSEDHLDLTPRV--------G--LTLNPS----AHKL--C--A-----VSCL-- Kryptolebias_marmoratus_CYP2K49 ------KEPPG------------P-RGLPVLGNL----------LQI-----DLKRP------H-HTFQELSK-----KYGSV--FTVYLGPKKVVV-LTGYKTVKEALVQ--YD---EEFGDRDSLPILR-EF--NKG--HG---ILWSNGDS-WREMRRFTLTNLRDFGMGR-------KVCEDKIIEECQRLTEVFKNF-----------NGK--P-----FETMQPINYAVSNIICSMVYGSRFE----YSDPE------FTSMV----DRTNRNIQLTGSASIQVY--NMFPWLFK-WLPTR-----KEINETF--EMNRNQNFSLFHQLRETLNPEMC----------------R-----GVVDA-F---MVRR-----------------QNLEKS------------------------G-VKNNHFHDDNLFMTVTNLFVAGTETTSTTLRWGLLLMAKYPNIQDQVQEELRRV--I-G---------------------------------------------------------------DR----------QVQVSD-RKNMPFTDAVIHETQ-RLGNIVPAALPHKTSKDFSF-HG--YFIKK------D-----------TTVYPLLTS-VLNDPAEWEKPHTFHPA------HF--LDK--DG--NFV------K--RDAFMPFSAG-----------RRICLGESLAR-MELFIFFTTLLQHFTFT----PAPGISRDELDLTPVG--------T--FTLNPS----PHKL--C--A-----VSRM-- Oryzias_latipes_CYP2K29 ------QEPPG------------P-RPLPIIGNL----------MQI-----DLKRP------Y-KTLEEFSK-----TYGPV--FTVFFGGEKVVV-LAGYKTVKNALVN--HD---EEFGERAIPPIIQ-EL--NKG--LG---VLWSNGDI-WRDIRRFALTNLRDFGMGK-------KACEDKITEECQYLLEVFKKF-----------KGN--A-----FDTTKPLNYAVSNIICSMVYGSRFE----YDDPK------FTSMV----DRTNRNIQLSGSPTLQAY--NMVPWLFK-WVASR-----REVHECA--AANRKQNQSIFSHLKETLNPQMC----------------R-----GFVDA-F---LVKG-----------------QTLEKS------------------------G-VTNSAFNDENLLMTVIHLFAAGTETTSTTLRWGLLLMAKYPKIQDQVQDELRRV--I-G---------------------------------------------------------------DR----------MVQVSD-RKNLPFTDAVIHEIQ-RLASIVPTALPHKTSKDVTF-QG--YFIKK------G-----------TTVFPLLTS-VLHDANEWEKPHTFYPA------HF--LDK--DG--KFV------K--REAFIPFSAG-----------RRICLGESLAR-MELFMFFTTLLQNFCFT----PPPGVSKEELSLTPCG--------G--ITVGPV----PHKL--C--A-----VPCSE- 'Takifugu rubripes CYP2K-like1' ------REPPG------------P-RALPLLGNL----------LQL-----DLSRP------H-QTLYQLSK-----KYGPV--FKVHFGPRKVVV-LAGHKTVKEALVG--NA---EQFGDRDISPIFY-DM--NQG--HG---ILFSNGET-WKEMRRFALSTLRDFGMGK-------RMIEDKIAEECNYLIQKFEDH-----------EGR--A-----FDTSRLANYATSNIISSIVYGSRFD----YDDPR------FINMV----NRANEVIRLTGSAPIQLY--NIFPGLAN-WIKNR-----QLLLKQV--AMNFRDMTDLIQQLKDTLNPGVC----------------R-----GFVDC-F---LLRK-----------------QKAVDS------------------------G-VIDSLYNEKNLLYSLSNLFGAGTDTTATTLRWGLLLMAKYPRIQDQVQQELSMV--V-G---------------------------------------------------------------NR----------RVCVED-RKNLPYVDAVIHEIQ-RLGNIAPMAVPHKTARDVEF-RG--YFIEKVKYFSEG-----------TTVFPLLTS-VLYDENEWETPHTFNPS------HF--LDK--DG--KFI------K--RDAFMPFSAG-----------RRLCLGEGLAK-MEIFLFFTSLLQQFRFT----PPPGVGEDELDLTPAL--------G--FTLSPS----PHKL--C--A-----IPRQ-- Oryzias_latipes_CYP2K27 ------KDPPG------------P-RPLPLLGNL----------LQL-----DPRRP------H-KALCELSK-----SYGPV--FTVYFGIQKVVV-LAGYKTVKEALVN--NA---EEFGDRDITPMFQ-DM--NKG--HG---ILFANGES-WKELRRFALTTLRDFGMGK-------RIAEEKILEECDYLIQGLEKH-----------QGN--P-----VDLTCPLNYATSNIISSIVYGSRFD----YDDPR------FRNLV----SRANETIRINGHPLTHLY--NMFPRWFR-WIKNR-----KIILNNV--EMTVKDVKDLVKHLKETLNPSVC----------------R-----GFVDC-F---LIKK-----------------QKEEDS-------------------------CVKESHFTEQNLVFSVSNLFAAGTDTTATTLRWGLLLMAKYPHIQDKVHEELAKV--L-G---------------------------------------------------------------GR----------QVRVDD-RKNLPYADAVIHEIQ-RVANIIPMSIPHKTNRDVTF-HG--YLIQK------G-----------TTVIPLLAS-VLNDENEWESPHTFNPH------HF--LSK--EG--KFV------K--RDAFMPFSAG-----------RRACLGESLAK-MELFLFFTSLLQRFHFT----PPPGVSEEELDLTPAM--------G--FVLAPS----SHEL--C--A-----VSLQ-- Kryptolebias_marmoratus_CYP2K38 ------KEPPG------------P-RPLPLLGNL----------LQL-----DLSRP------Y-RTLCEFSK-----NYGSV--FTVYFGPRKVVV-LAGYETVKEALVS--YA---EEFGDRDISPIFN-DI--TRG--HG---ILFSNGDS-WKEMRRFALYTLRDFGMGK-------RVVEEKILEECGHLIQMFENQ-----------KGK--P-----FDTAHPLNYATSNIICSVVYGSRYE----YNDPR------FRNMV----SRASENIRLSGSAQIQIY--NMFPWLFR-WIKNC-----QLMLKNV--EMTIRDMKAIVTQLKETLDPQRC----------------R-----GLVDC-F---LIQK-----------------QRDEDS------------------------G-VKDTHFHEENLIFTATNLFAAGTETTATTLRWSLLLMAKYPHIQDQVREELLRV--I-G---------------------------------------------------------------NR----------AARVED-RKNLPFTDAVIHETQ-RLANIVPMSIPHKTSQDVTF-QG--YFIKK------D-----------TIVIPLLTS-VLHDEREWESPHTFNPS------HF--LDK--EG--KFI------K--RGAFLPFSAG-----------RRVCLGESLAK-MELFLFFTSLLQRFHFT----PPPGVSEDELDLTPAI--------G--FTIPPS----PHKL--C--A-----VSHQ-- Danio_rerio_CYP2K16 ------NEPPG------------P-KPLPLLGNL----------LML-----DVNKP------H-LSLCEMAK-----QFGPV--FKVYFGPKKVVV-LAGYKAVKQALVN--YA---EAFGDREIMPLFH-DF--TKG--HG---IIFANGES-WREMRRFALTNLRDFGMGK-------KKIEEKIIEETCHLREEFEKF-----------EGK--P-----FETAQLMNYAASSVISSIVYGRRFE----YTDPQ------LRTMV----DRANESVRLSGSASVQLY--NMFPFLGP--LLKN----WRQLMKNL--HLDIEEISELVNGLHQTLNHQDL----------------R-----GFVDS-F---LVRK-----------------QYAEDS------------------------G-EKDSHFHEQNLIYTVGNLFVAGTDTTSTTLRWSLLLMAKYPHIQDRVQEEIDQV--I-G---------------------------------------------------------------GR----------QPVSED-RKNLPYTDAVIHETQ-RLANIVPMSIPHMTSSDITF-NG--YFIKK------G-----------TCIFPLLTS-VLWDEDEWETPHIFNPN------HF--LDE--QG--RFV------K--RDAFMPFSAG-----------RRICLGESLAR-MELFLFFTSLLQYFRFT----PPPGVSEDELELTPAV--------G--FTLNPI----AHKL--C--A-----VKRL-- Danio_rerio_CYP2K8 ------EDPPG------------P-KPLPLLGNL----------HTL-----DLKNL------H-VSLWELSK-----KYGPV--FKVHLGRKKVVV-LAGYKTVKQALVN--QA---EEFGERDITPIFQ-DC--NQG--QG---IVFANGER-WRTMRRFALSTLRDFGMGK-------KLSEEKIVDETRYLREVFMKF-----------EGQ--P-----FDTTQPVNYAVSNIISAIVYGKRFE----YEDPA------FQDMV----NKANMNIRMIGSAVIQIY--NMCPFLGP--WIKT----WRQLMKNM--ESTRRQIQTLADVLQETLNPLDC----------------R-----GLIDS-F---LIRK-----------------QNIQET------------------------G-EKDSSFNDQNLLITVSNLFAAGTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDQV--L-G---------------------------------------------------------------GR----------EPVAED-RKNLPYTDAVIHETQ-RLANILPLNLPHKTSCDVTF-NG--YFIKK------G-----------TCVLPLLTS-VLRDETEWETPDTFNPQ------HF--LDE--KG--QLI------K--RDAFMPFSAG-----------RRACLGESLAR-MELFLFFTSLLQYFRFS----PPPGASEDELDLTPVV--------G--LTLNPS----PHKL--C--A-----VIRAE- Danio_rerio_CYP2K17 ------KDPPG------------P-KPIPLLGNL----------LTL-----DLSRP------F-DSLCELSK-----TYGNV--YQVFLGPKKVVV-LIGHKTVKEALVN--FA---DEFGERDITPIFR-IL--AND--HG---ILFSNGES-WKEMRRFAISNLRDFGMGK-------RGSEEKIIEEIHHLKGEFDKF-----------EGK--P-----FDTTQPVNYAVSNIISSIVYGSRFE----YTDPR------FTEMV----DRANENIRVSGSASMMLY--NIFPWLGP--FLNS----KRTVVRNM--LKNRAEFMKLITGLQETLNIHDR----------------R-----GFVDS-F---LIRK-----------------QSDEQL-------------------------GKKDTYFHAENLLMTVGNLFAAGTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDRV--I-G---------------------------------------------------------------GR----------QPVVED-RKKLPYTDAVIHEIQ-RLANIVPMNLPHVTSCDVTF-NG--YFIKK------G-----------TTVIPLLTS-VLKDESEWEKPNSFYPE------HF--LDE--KG--QFI------K--RDAFMPFSAG-----------RRVCLGESLAR-MELFLFFASLLQSYRFT----TPPGVSEDELDLKGTV--------G--VTLNPS----PHKL--C--A-----IKRF-- Danio_rerio_CYP2K18 ------KEPPG------------P-KPLPLLGNL----------LTL-----DLTRA------F-DTFFELSK-----TYGNI--FQVYLGPKKTVV-LVGYKTVKEALVN--HA---EAFGDREIGPSFR-IM--NDE--HG---IVFSNGEN-WKEMRRFALSNLRDFGMGK-------RGSEEKIIEEIHHLKGEFDKF-----------EGK--P-----IDTTEPVNYAVSNIISSIVYGSRFE----YTDPQ------FTEMV----DRANENVRVGGSISMGLY--NMFPWLGP--FLKN----KRIVVRNI--IQSRVQMTKLITALLETLNPNDP----------------R-----GFVDS-F---LIHK----------------LSDEKSG--------------------------KKNSYFHNENLMMNVANLFVAGTDTTGTTLRWGLMLTAKYPQIQDRVQEEIDRV--I-G---------------------------------------------------------------GR----------QPAVED-RKKLPYTDAVIHEIQ-RFANIVPLNLPHTTSCDITF-NG--YFIKK------G-----------TTVIPLLTS-VLKDESEWEKPNSFYPE------HF--LDE--KG--QFV------K--RDAFMPFSAV-----------------------------ILTLMSDARAI-----------------------------------------------E-------------- Danio_rerio_CYP2K20 ------KEPPG------------P-KPLPLVGNL----------LTL-----DLTRS------F-DTFFELSK-----TYGNI--FQVFLGHRKTVV-LVGYKTVKEALVN--YA---EVFGDREIGPGFNDMV--LCG--SG---ILFSNGEN-WKEMRRFALSNLRDFGMGK-------RGSEEKIIEEIHHLKGEFDKF-----------EGK--P-----FDTTQPVNYAVSNIISSIVYGSRFE----YIDPR------FTEMV----ARANENVRVGGSFSMMIY--NIFPWLGP--FLKN----RAVVVKNI--TQNRAEKKKLITALLETLNPHDP----------------R-----GFVDS-F---LIHK----------------LSDEKSG--------------------------KKDSYFHEENLMLTVANLFAAGTDTTGTTLRWGLMLMAKYPHIQDRVQEEIDRV--I-G---------------------------------------------------------------GR----------QPVVDD-RKKLPYTDAVIHEIQ-RLANIVPLSLPHRTTSDITF-NG--YFIKK------G-----------TTVVPLLTS-VLKDESEWEKPNSFYPE------HF--LDE--KG--QFV------K--RDAFMPFSAG-----------RRVCLGESLAR-MELFLFFTSLLQSYRFT----TPPGVSEDALDLKGIV--------G--ITLNPS----PHKL--C--A-----IRRS-- Danio_rerio_CYP2K19 ------KEPPG------------P-KPLPLLGNL----------LTL-----DLTRA------F-DTFFELSK-----TYGNV--FQVFLGPRKTVV-LVGYKTVKEALVN--YA---EQFGDREIGPGFR-IM--NDE--HG---ILFSNGEN-WKEMRRFALSNLRDFGMGK-------RGSEEKIIEEIHHLKGEFDKF-----------EGK--P-----FDTTQPVNYAVSNIISSIVYGSRFE----YTDPQ------FTEMV----DRANENVRVGGSVSMWFH--EMFPWVGP--FLKS----KRIIVENI--IQSRAQMTKLITALLETLNPNDP----------------R-----GFVDS-F---LTRK----------------LSDEKSG--------------------------KKDSYFHEENLIMTVTNLFVAGTDTTGTTLRWGLMLMAKYPQIQDRVQEEIDRV--I-G---------------------------------------------------------------GR----------QPVVED-RKKLPYTDAVIHEIQ-RLANIVPLSLPHKTTSDITF-NG--YFIKK------G-----------TTVVPLLTS-VLKDESEWEKPNSFYPE------HF--LDE--KG--QFV------K--RDAFIPFSAG-----------RRVCLGESLAR-MELFLFFTSLLQSYRFT----TPPGVSEDELDLKGIV--------G--ITLNPS----PHKL--C--A-----IRRS-- Danio_rerio_CYP2K21 ------KEPPG------------P-KPLPLVGNL----------LTL-----DLTRP------F-DTFFKLSK-----TYGNV--FQVYLGPEKAVV-LVGYKTVKEALVN--YA---EEFGDREIGPGFS-IM--NDE--HG---ILFSNGEN-WKEMRRFALSNLRDFGMGK-------RGSEEKIIEEIHHLKGEFDKF-----------EGK--P-----FDTTQPVNYAVSNIISSIVYGSRFE----YTDPQ------FTEMV----DRANENVRVGGSISMWLY--DIFPWLGP--FLKN----KRIIVENI--IQSRVQMTKLITALLETLNPNDP----------------R-----GFVDS-F---LIRK----------------LSDEKSG--------------------------KKDSYFHEENLMMTVTNLFIAGTDTTGTTLRWGLMLMAKYPHIQDRVQEEIDRV--I-G---------------------------------------------------------------GR----------QPVVED-RKKLPYTDAVIHEIQ-RLANIVPLSLPHRTTSDITF-NG--YFIKK------G-----------TTVVPLLTS-VLKDESEWEKPNSFYPE------HF--LDE--KG--QFV------R--RDAFMPFSAG-----------RRVCLGESLAR-MELFLFFTSLLQSYRFT----TPPGVSEDELDLKGIV--------G--ITLNPS----PHKL--C--A-----IRRS-- Danio_rerio_CYP2Y3 ------SLPPG------------P-LALPLIGNL----------LTL-----DKSAP------F-KSFMKWRK-----TYGSV--MTVHLGPQRMVV-LVGYETVKEALVD--QA---DDFAPRAPIPFMN-RI--VKG--YG---LAISNGER-WRQLRRFTLTTLRDFGMGR-------KRMEQWIQEESRYLLKSFEET-----------KSK--P-----VDPTFFFSRTVSNVICSLVFGQRFD----YEDKN------FLQLL----QIISKLLRFLSSPWGQLY--NIFPQVME-RFSSR----HHAILKDV--ENIRTFIRSKVKEHEQRLDFSDP----------------S-----DFIDC-F---LIRL-----------------TQEKDK---------------------------LDTEFHKDNLMATVLNLFVAGTETTSTTLRYALMLLIKHPQIQEQMQREIDRV--I-G--------------------------------------------------------------QNR----------IPTMED-RKSLPFTDAVIHEVQ-RYMDIVPLSLPHYAMKDITF-RG--YKIPK------D-----------TVIIPMLHS-VLRDEGQWETPWTFNPE------HF--LDS--NG--NFQ------K--NPAFMPFSAG-----------KRSCVGESLAR-MELFLFTVSLLQKFTFS----SPNG--PDGIDLSPEL-------SS--FANMPR----FYEL--I--A-----SPR--- Danio_rerio_CYP2Y4 ------SLPPG------------P-LALPLIGNL----------LTV-----ETSAP------F-KSFMKWSK-----SYGPV--MTVHIGTQRMVV-LVGYETVKEALVD--QA---EDFASRAPIPFTN-RV--LRG--YG---LIISNGER-WRQLRRFTLTTLRDFGMGR-------KRMEQWIQEESRYLLKSFEET-----------KSK--P-----VDPLFFMSRAVSNVICSLVFGQRFD----YEDKN------FLQLL----QIISNLMRFASSPWGQLY--NIFPKVME-ILPGR----HHTMFGEI--DDLKSSIMTIIKEHEENLDPSDP----------------K-----DFIDC-F---LIRL-----------------NQEKHN---------------------------PDTEFHKENMFATSLNLFTAGTETTSTTLRYALMLLIKHPHIQEQMQKEIDCV--I-G--------------------------------------------------------------QNR----------IPTMED-RKSLPFTDAVIHEVQ-RCLDIAPLNVPHYALKDITF-RG--YKIPK------D-----------TVIIPMLHS-VLRDEGHWETPWTFNPE------HF--LDS--NG--NFK------K--NPAFMPFSAG-----------KRVCVGESLAR-MEIFLFIVSLLQKFSFS----SPNG--PDSIDPSPEL-------SS--FGNMPR----LYEL--I--A-----SPR--- 'Takifugu rubripes CYP2Y-like' ------NLPPG------------P-TTLPLVGNL----------PQL-----DKKQP------F-KSFTELSK-----SYGPV--MTLYLGWQRTVV-LTGYEVVKEALVD--QA---EDFTGRGPLPFLL-KA--TNG--YG---LGISNGER-WRQLRRFTLSTLRDFGMGR-------KGMEEWIQEESKHLTARIKTL-----------KVK--P-----FDPTFLLGCTVSNVICCMVFGERFS----YDDKQ------FLELL----RVIAEVLRFNSSFLGQMY--NVFPWILE-HLPGP----QHTMFSHV--NFLREFIKKKIQEHKESLDPSSP----------------R-----DYIDT-F---LIRM-----------------EQEKNL---------------------------PNTEFHYENLVSTVLNLFLAGTETTSSTLRYALGVLIKHPNVQEEMQREIDNV--V-R--------------------------------------------------------------QDQ----------CPKMED-RKSLPFTDAVIHEVQ-RFLDIVPFGLPHYALKDITF-RG--YSIPK------G-----------TVIIPLLHS-VLKGDQ-WETPWAFNPK------HF--LDQ--NG--SFK------K--NSAFLPFSAG-----------KRSCVGESLAR-MELFIFLVTLLKDFTFS----CIEG--PDSISLNPQY-------SG--FANLPR----NYEI--V--A-----TLR--- Kryptolebias_marmoratus_CYP2Y9 ------RLPPG------------P-SALPLIGNL----------LQI-----NKEAP------F-KSFVELSR-----TYGPV--MTLQLGWQRSVV-LAGYDAVKEALVD--QA---EDFTGRAPVPFLH-RA--TKG--FG---LGISNGER-WRQLRRFTLTTLRDFGMGR-------KGMEEWIQEESKYLRECIHSY-----------KGK--P-----FDPTVLLSRTVSNVICCLVFGQRFS----YEDKQ------FVELM----ATISEIARFNSSPLGVMF--NLFPWLME-RLPGK----HQVVFGKI--ERVREFVMKKIQEHKETLDLSSP----------------R-----DYIDC-F---LIRA-----------------EQEKNN---------------------------PSTEFHYENLVGTVMNLFVAGTETTSSTIRYALSVLIKYQEIQDKMQEEIDTV--I-G--------------------------------------------------------------KNR----------CPSMED-RKSLPFSDAVIHEVQ-RLLDIVPFSIPHYALQDISF-RG--YTIPK------G-----------TLIFPLLHS-VLKDETQWVNPISFDPQ------HF--LDQ--NG--NFK------K--NPAFLPFSAG-----------KRACVGESLAR-MELFVFIVGILQDFIVS----CPEG--PDSINLVPEF-------SS--FANLPR----CYNI--I--A-----TPR--- Oryzias_latipes_CYP2Y6a ------HLPPG------------P-PALPLIGNL----------LQL-----DKKRP------F-RTIVELSK-----THGPV--MTIYMGWQRAVA-LVGYDAVKEALVD--QA---DDFVGRAPLPFLY-RA--TRG--YG---IGISNGER-WRQLRRFALTTLRDFGMGR-------KGMEQWIQEESRHIRAKINTF-----------KGK--P-----FDPTFILSCTVSNVICCLVYGERFN----YDDKQ------FLELL----QIISEVPRFNSSPMGAMY--NLFPWLME-RLPGR----QHTIFGYI--EDIRKFAKNKIQEHKDKLDPSSP----------------R-----DFIDC-F---LLRM-----------------DQEKDN---------------------------PTSEFHYENLLAMVLNLFLAGTETTSSTIRYALSVLIKHPKIQEKMQEEIDSV--I-G--------------------------------------------------------------RER----------CPSMEE-RKSLPFTDAVIHEVQ-RFMDLTPFSLPHYSLKDISF-RG--YTIPK------D-----------TMIFPMLHS-VLREDKLWSSPWSFNPQ------NF--LDQ--NG--NFK------K--NPGFVPFSAG-----------KRACVGESLAR-MELFLFIVSFLQDFTFS----APNG--PDSINLVPEY-------SS--LANLPR----RYEL--I--A-----TPR--- Oryzias_latipes_CYP2Y6b ------HLPPG------------P-PALPLIGNL----------LQL-----DKKGP------S-RTIVELSK-----TYGPV--MTIYMGWQRAMA-LVGYDAVKEALVD--QA---DDFVGRAPLPFFY-RA--SRG--YG---IGISNGER-WRQLRRFTLTTLRDFGMGR-------KGMEQWIQEESRHLRAHIMSF-----------KGK--P-----FDPMFKLSCAVSNVICCFVYGERFN----YDDKQ------FLELL----KMISEILDFNGGPIGAMY--NLCPWLLE-HLPGH----QHTVFGYI--EVTRNYAKKKIQEHKDTLDPSFP----------------R-----DFIDR-F---LIHM-----------------DQEKDN---------------------------PTSEFHYENLLAMVQNLFLAGTETTSSTIRYALSVLIKHPKIQEKMQEEIDSV--I-G--------------------------------------------------------------RER----------CPSMED-RKSLPFTDAVIHEVQ-RFMDLAPFSLPHYSLKDISF-RG--????K------D-----------TMIFPMLHS-VLREDKLWSSPWSFNPQ------NF--LDQ--NG--NFK------K--NPGFVPFSAG-----------KRACVGESLAR-MELFVFIVSLLQNFTFS----APNG--PDSINLDPEY-------SG--LTNQHC----RYEL--I--A-----TPR--- Danio_rerio_CYP2AE1 ------NMPPG------------P-FPLPFVGNL----------TNI-----GFSDP------L-GSFQRIAE-----KYGDV--CTLYLGTKPCIL-MTGYDTLKEAFVE--QA---DIFTDRPYFPIVD-KL----GNGKG---LIMSSGHM-WRQQRRFALATLKYFGVGK-------KTLENAILQECRFLCDSLQAE-----------RGL--P-----FDPQHLVTNAVSNIICGLVFGHRFE----YDDHQ------FHLMQ----TYINNILQLPISNWGRLY--NEFPTLMS-LLPGK----HQTAFASM--SKLQPFLKEEITKHQQDREPSSP----------------R-----DYIDC-Y---LEEI-----------------EKCKDS----------------------------DAEFTEENLMFCVVDLFGAGTETTSNTLRWALAFMVKYPDVQEKVQSEIDQV--I-G--------------------------------------------------------------QTR----------QPLMDD-RTNLPYTYAVIHEIQ-RFANIVTFTPPRVANKDTTV-GG--QLIPK------G-----------VIVLPMLKP-ILLDKKEYSTPYDFNPD------HF--LDQ--NG--KFL------K--KENFIPFSIG-----------KRMCPGEQLAR-MELFLFFISLMQHFTFL----PVEG---QKLSLKGTT--------S--VSSAPQ----PFQI--R--A-----VPR--- Danio_rerio_CYP2AD6 ------NFPPG------------P-WPLPILGNV------------F-----TDVNY--------KTVDQLIE-----KYGNI--FSVRIGSDKIVY-VSGFKMVKDVLIT--QG---ENFTDRPVSPLFD-TL--YKG--RG---LSFNNGYS-WRKHQQFSMSHLKNFGEGR-------KTLEENNQRECYFLCGAFKEE-----------QGR--P-----FDPLVKINNAVANVIGFLVFGHRYE----YSDVN------FQKRL----QMSAESVFLTGSVWNQLY--DAFPGIMK-WVPGP----HQTIISNY--QKLANFLEEKIEQHKPDWDISNP----------------R-----DYIDA-Y---LTEA-----------------EKKKND---------------------------TEAGFTVGSLVWSMVDLFEGGTETTTNTLRWALLFLIKYPDIQKKVQAEIDEV--I-G---------------------------------------------------------------SR----------LPSMSD-KANMHYLNAFIHEVL-RRANLVPLNMARVAKKDTTL-GG--YFITK------G-----------TVMITNLTS-VLYDKQEWETPDAFNPK------HF--LDS--EG--HFC------R--RNAFFAFSAG-----------KRQCPGEYLAH-LELFIFLTILLQTFSFS----PPDG---EEPSLDSQV--------G--FTQAPL----PYKI--C--A-----HPR--- Danio_rerio_CYP2AD2 ------NYPPG------------P-WPLPFLGTV------------F-----TKMDF--------KNINKLAK-----VYGKV--FSLRVGSEKMII-VSGYKMVKEALVT--QN---DSFVLRPPVPLFH-KV--YKG--IG---LTMSNGYI-WRSHRRFAASHLRTFGEGK-------KNLELGIQQECVYLCDAFKAE-----------KEP--------FNPIFILHGAVSNTVACLTFGQRFD----YNDEW------YQEIL----RLDNQCVQLAGSPRVQLY--NAFPKLLD-YLPGP----HQKVFSNY--KKITQSLKDEIIKHREDWDPANP----------------R-----DFIDN-Y---LTEM-----------------EKKKSD---------------------------PQAGFNIESLIISCLDIVEAGTETGATTLRWGLLFMIKFPEIQKKVQAEIDRV--I-G--------------------------------------------------------------QSR----------QPCLDD-RVNMPYTEAVLHEIQ-RFGDVVPLGFPKQAAVDTKI-GN--YFIPK------G-----------TSITTNLSS-VLHDPNEWETPDTFNPG------HF--LDK--NG--QFR------K--RDAFLPFSAG-----------KRACVGELLAR-NVLFLFFTSLLQQFTLS----KCPG---EEPSLEGEI--------W--FTYAPA----PFRI--S--V-----SVR--- Danio_rerio_CYP2AD3 ------SFPPG------------P-RPLPFLGNV-----------FT-----EIQDF--------RNINKLAQ-----VYGTI--FSLRLGSEKLII-VSGYKMAKEALVT--QN---DSFIDRPNVPLFH-KV--FKG--LG---TILSNGYL-WRMHRKFAVSHLRNFGVGN-------ESLEVKIQQECIFLCDAFKAE-----------KGP--------VDPMVTLNSAISNIISSLIFGQRFD----YHDEY------YQRIL----RLDTECIQLAGSPRAQLY--NACPWLFE-YLPGP----HQTIFSNY--KKIKDFLRGEIIKHREDWDPANP----------------R-----DFIDN-Y---LTEM-----------------ERKKSD---------------------------PEAGFNIEGLVVTCLDLIEAGTETATTTLRWGLLFMIKFPEIQEKVQAEIDRV--I-G--------------------------------------------------------------QSR----------QPCLND-RVNMPYTEAVIHEIQ-RFGDVVPLGFPKRAVKDTQL-GK--YFIPK------G-----------TAITVNLSS-VLHDPNEWETPDTFNPG------HF--LDE--IG--QFR------K--RDAFMPFSAG-----------KRACLGENLAR-QELFLYFTSLLQQFKIS----KCPG---EEPSLEGEI--------W--FTYAPA----PFHI--C--V-----SSR--- 'Takifugu rubripes CYP2AD-like' ------NFPPG------------P-WAMPFVGNI------------F-----TGVDF--------RTIEKLSQ-----KYGPV--FSLRRGNTRTVF-INGYKMVKEALVS--QL---DSFEDRPVVPLFH-VV--FKG--IG---IALSNGYM-WKKQRKFAHTHLRYFGEGQ-------KLLENHIQMESKFMCEAFKDE-----------QGK--P-----FDPQYTITNAVGNIISALVFGHRFE----YSDAS------FRRIL----ELDNEAVVLAGSARTQLY--DSFPSLMK-HLPGP----HQTVHANY--GKITDFLKKEVDKHMEEWNPEDP----------------R-----DYVDT-Y---LSEM-----------------EKMNQD---------------------------PQGGFNVETLLICILDLIEAGTESAATTLRWGLVFILNYPDVQEKVQEEIDRV--I-G--------------------------------------------------------------QSR----------QPAMAD-RPNMPYTDAVIHEIQ-RFANVVPAGFPKMATKDTTV-GG--YFIPK------G-----------LAITTMLSS-VLFDKNEWETPDVSTPI-----ISW--TQR--VD--SAK------EMPSFHFLQVSAC--------------ASGKTWPK------------WSSSFS----SPPS---CSISISLLF-----------LDKCP-----AWRV--S--WASPTLHSHSE- Oryzias_latipes_CYP2AD7 ------KFPPG------------P-LSVPFLGNV------------F-----TGVDF--------KTMEKLSQ-----DFGPV--FSLRRGSERMVF-ISGYKMVKEALVT--QL---DSFVDRPIVPLFH-VV--FKG--LG---IALSNGYL-WKKQRKFANAHLRYFGEGQ-------KSLERYIEIESNFLCDAFKEE-----------QGR--P-----FNPHYLITNAVGNIISSVVFGHRFE----YSDPS------FRKVL----ELDNEAVVLSGSARTQLY--DAFPSLLN-YLPGP----HQTVHANY--REIVCFLRKEIEKHQEEWNPEDP----------------R-----DYIDV-Y---LSEM-----------------EKTKQD---------------------------PQAGFNIETLVVSTLDLIEAGTETTATTLRWGLMFMLHHPEIQEKVQEEIDRV--I-G--------------------------------------------------------------QSR----------QPAMSD-RPNLPYTDAVIHEIQ-RMGNIVPLGFPKMASKDTTL-GG--YFIPK------G-----------TPITTILSS-VLFDKNEWETPHVFNPG------HF--LDS--EG--RFL------K--KEAFLPFSAG-----------KRMCLGEHLAK-MELFLFFSTLLQRFTFK----PVPG---EMPSLEGVL--------G--FTHSPE----EFRF--L--A-----LPR--- Kryptolebias_marmoratus_CYP2AD12 ------NFPPG------------P-WAVPFLGNV------------F-----TGVDF--------KSINKLTK-----EYGPV--LSLRKGSERFVF-ISGYKMVKEALVN--QL---DSFIDRPIVPLFD-VI--YKG--LG---ITMSNGYL-WKKQRKFANCHLRYFGEGH-------KSLEKYIEVECSFLCEAFKEE-----------QGK--P-----FNPHYMMKMAVSNIICSVVFGHRFE----YSDPS------LRKVL----ELDNEAIVLSGSLRTQLY--DVIPGLMK-YLPGP----HQTVHANY--REILSFLMKEIEKHQEEWNPDDP----------------R-----DYIDV-Y---LAEM-----------------KKHKED---------------------------PLAGFNIETLQFCTLDLIEAGTESAANTLRWALVYMMNFPEIQEKVQAEIDRV--I-G--------------------------------------------------------------QSR----------QPTIAD-RPNLPYTEAVVHESQ-RIGNIVPMGFPKMASKDTTL-GG--YFIPK------G-----------TAITTNLAS-VLFDKNEWETPDVFNPG------HF--LDS--EG--KFL------R--KEAFLPFSAG-----------KRVCIGENLAK-MELFLFFTTLLQHFTFV----PVPG---EMPSLEGVM--------G--FTYSPQ----EFRM--L--A-----VPR--- 'Kryptolebias marmoratus CYP2AD12-iso' ------NFPPG------------P-WAVPFLGNV------------F-----TGVDF--------KSINKLTK-----EYGPV--LSLRKGSERFVF-ISGYKMVKEALVN--QL---DSFIDRPIVPLFD-VI--YKG--LG---IALSNGYL-WKKQRKFANCHLRYFGEGH-------KSLEKYIEVECSFLCEAFKEE-----------QGR--P-----FNPHYMMKMAVSNIICSVVFGHRFE----YSDPS------LRKVL----ELDNEAIVLSGSLRTQLY--DVIPGLMK-YLPGP----HQTVHANY--REILSFLMKEIEKHQEEWNPDDP----------------R-----DYIDV-Y---LAEM-----------------KKHKED---------------------------PLAGFNIETLQFCTLDLIEAGTESAANTLRWALVYMMNFPEIQEKVQAEIDRV--I-G--------------------------------------------------------------QSR----------QPTIAD-RPNLPYTEAVVHESQ-RFGNIAPMGFPKMASKDTTL-GG--YFIPK------G-----------TAITTNLAS-VLFDKNEWETPDVFNPG------HF--LDS--EG--KFL------R--KEAFLPFSAG-----------KRVCIGENLAK-MELFLFFTTLLQHFTFV----PVPG---EMPSLEGVM--------G--FTYSPQ----EFRM--L--A-----VPR--- Danio_rerio_CYP2V1 ------NLPPG------------P-TPLPFIGNV----------FNL-----DTSQP------H-IDLTKMSD-----HYGNI--FSLRLGSLNTVV-VNTYSMVKKVLND--QG---NSFMYRPVNDITE-RI----SKCQG---LTFNNGYS-WKQHRRFTLSTLKFFGVGK-------RSLEFIIMEEYKFLHQSIMDT-----------NGL--P-----FNPHYIINNGVSNIICSMVFGRRFE----YTDQR------FLNML----SLISKALKLQTSVFIQLY--AAFPRLMD-LLPGP----HKELFSCF--HQVRAFIKEEVDKHRADWDPSSP----------------R-----DFIDC-Y---LTEI-----------------EKKKDD---------------------------LEAGFHDEGLQYAVLDLFVAGTETTSTTLLWAFVYMMKYPEIQEKVQAEIDKV--V-G--------------------------------------------------------------RYR----------RPSMDD-RPCMPYTDAVIHEIQ-RMGNVVPLSVPRMTNEDTIL-EG--YFIPK------G-----------TQIIPNLTS-VLFDQTKWKTQHSFDPQ------NF--LNA--QG--KFE------K--PEAFIPFSLG-----------KRSCPGESLAR-MELFLFFTSFLQSFSLS----APDE---TQTSLDFKF--------G--MTLSPK----PFKI--C--F-----TPR--- 'Takifugu rubripes CYP2Z-like' ------SFPPG------------P-WTLPVVGNM----------HNL-----AHHRM------H-LNLMELAE-----TYGNV--FSIQLGQEWMVV-LNGPTILKEALVN--QG---DSVADRPNLQLII-DS--CHG--LG---LGFSSGHL-WKQQRQFAISTLRYFGSGS-------KSLEPVVLEEFAHCAKQFSEF-----------KGK--P-----FAPQLMFYNIVTNIICSLVFGHRFE----YGDKN------FEKLM----NSFGRCLQIEASVCAQLY--NSFPRLMG-CLPGP----HQTVKRIY--QNIRDFIREEMKEHKKGLDPSTP----------------R-----DYIDC-Y---LNKI------------------KKSNL--------------------------EPHNTFHEENLVICVWDLFLAGTDTTTCTLRWLFLFMAKYPEMQEKVQAEIDEV--I-G--------------------------------------------------------------QSR----------RATMDD-CVNMPYTNAVIHESL-RMGNVVPLSLLHATGRDIQL-EG--YTIPK------G-----------TTVIANLTS-ALFDKNEWETPFAFNPG------HF--LDE--EG--RFR------K--RTAFLPFSAG-----------RRLCLGENLAR-MMLFLFFTSFMQDFTIS----FPAG---VSPAMEYHH-------FG--VTLAPH----PFDI--C--A-----VSR--- 'Oryzias latipes CYP2N-like2' ------SFPPG------------P-PGLPILGNI----------FTV-----DVGRP------H-ESFSKLAA-----EYGDL--YSLRFGQRWTVV-LNGHKALKEALVT--KG---DSVVDRPHLPLQD-EI--AKG--LG---VIFSNGAN-WTEQRRFALSTLRYFGFGK-------KSLEPVILNEFAHCAEELKRF-----------KGE--P-----LDPHLIINNTVSNIICHLVFGHRFN----YGDKK------FKKLM----LLFDRALQIEASIWAQLY--NSFTLIMR-CLPGP----HKTLQHIW--REVQDFIGEELKEHKKSWDPSDA----------------R-----DYIDF-Y---LTEI-----------------QKTKGQ---------------------------EGSTFDEENLIMCVLDLFVAGSETTSTTLRWAFLYMAKYPEIQEKVQAEIHKV--I-G--------------------------------------------------------------KSR----------PPCMED-RAELPYTDAVIHEVQ-RIGNIVPLSLPHATNKDVQL-GG--FTIPK------G-----------VLIIPNLTS-VLFDEKEWETPHAFNPG------HF--LNK--DG--KFV------K--RGAFIPFSAGEQQQSQHGSARKRLCLGENLAR-MELFLFFTSFMQHFSFS----MPAG---VEPVLDYRA--------G--LTLAPK----PYKI--C--V-----QASSE- Kryptolebias_marmoratus_CYP2Z6 ------GYPPG------------P-RAYPIVGNI----------FTL-----NPNRT------Y-ESLMELAK-----TYGDV--YSLRFGQNKTVV-LNGFEAVKEGLAT--KG---DSTIDRPIFPLQD-EI--CGG--LG---VIFSNGNI-WKQQRRFALSTLKYFGFGK-------KSLEPVILEEFTHCAEEIKRY-----------KGK--P-----FNPHLVINYAVSNIICHLVFGHRFD----YGDEK------FTKLM----LLFDKCLQIEASIWSQLY--NSFTLLMR-CLPGP----HQNLKQHW--NIVKNFIREEMEEHKKKWDPFER----------------R-----DYIDC-Y---LNEI------------------QMNQG--------------------------QDDNTFDEENLIMCVLDLFVAGSETTSTTLRWAFLYMAKYPEIQEKVQAEIDSV--I-G--------------------------------------------------------------QSR----------QPSMED-RANLPYTDAVIHEIQ-RIGNIVPLSLPHSTNREIQL-GG--YTIPK------G-----------VLIIPNLAS-VLFDKNEWETPFTFNPG------HF--LNK--EG--KFV------K--RAAFIPFSAG-----------KRLCLGENLAR-MELFLFFTSFMQHFTFS----MPAG---VQVVLDYRA--------G--VTLAPK----PFEI--C--I-----TSRQD- 'Kryptolebias marmoratus CYP2Z6-like' ------GYPPG------------P-RAYPIVGNI----------FTL-----NPNRT----------YESLME-----TYGDV--YSLRFGQNKTVV-LNGFEAVKEGLAT--KG---DSTIDRPIFPLQD-EI--CGG--LG---VIFSNGNI-WKQQRRFALSTLKYFGFGK-------KSLEPVILEEFTHCAEEIKRY-----------KGK--P-----FNPHLVINYAVSNIICHLVFGHRFD----YGDEK------FTKLM----LLFDKCLQIEASIWSQLY--NSFTLLMR-CLPGP----HQNLKQHW--NIVKNFIREEMEEHKKKWDPFER----------------R-----DYIDC-Y---LNEI------------------QM--G--------------------------QDDNTFDEENLIMCVLDLFVAGSETTSTTLRWAFLYMAKYPEIQEKVQAEIDSV--I-G--------------------------------------------------------------QSR----------QPSMED-RANLPYTDAVIHEIQ-RIGNIVPLSLPHSTNREIQL-GG--YTIPK------G-----------VLIIPNLAS-VLFDKNEWETPFTFNPG------HF--LNK--EG--KFV------K--RAAFIPFSAG-----------KRLCLGENLAR-MELFLFFTSFMQHFTFS----MPAG---VQVVLDYRA--------G--VTLAPK----PFEI--C--I-----TSRQD- Danio_rerio_CYP2P6 ------NFPPG------------P-WPLPIIGNL----------YHI-----DFNKI------H-LEVEKLSE-----KYGSV--VSVHLFGQRTVI-LNGYKQVKEVYIQ--QG---DNVADRPELPMIH-DI--AGD--NG---LVAPSGYK-WKQQRRFALSTLRNFGLGK-------KSLEPSINLECHYLNEAISNE-----------NGR--P-----FDPHLLLNNAISNVICVLVFGNRFD----YSDHH------FQTLL----NDINEAMYLDGTIWAQLY--NSYPRIMR-LLPGP----HKKNITLW--NKVIDFARERVKEHRVDYDPSNP----------------R-----DYVDC-F---LAEM-----------------EKLKDD---------------------------TAAGFDVENLCICTLDLFVAGTETTSTTLSWSLLYMIKYPEIQAKVQEEIDRV--I-G--------------------------------------------------------------SSR----------HPSVSD-RDNMPYTNAVIHEIQ-RFGNIAALNLPRAAVKDIQV-GK--YLIPK------G-----------TIVIGNLTS-VLFDESEWETPHSFNPG------HF--LDA--EG--KFR------R--RDAFLPFSLG-----------KRVCLGEQLAR-MELFLFFTSLLQHFTFS----SPAG---VEPSFNYKL--------G--TTRAPK----PFKL--C--A-----VSR--- Danio_rerio_CYP2P7 ------NFPPG------------P-WSLPFIGHI----------HHI-----EHKKV------H-LQFLKFAE-----KYGKI--FSIRLFGPRIVV-LDGYKLVKEVYLQ--QG---DNLADRPILPMFY-DI--TED--KG---LIGSNGYK-WKHQRRFALSTFRTFGLGK-------KSLEPSILLECSCLNDAFSNE-----------QGR--P-----FDPRLLLNNAVSNVICALVFSNRFD----YSDHH------FQTLL----KHINEVLYLEGTVWAQLY--NFFPWLMR-RLPGP----HQKIFVLL--NKVIDFVREKVNEHRVDYDPSNP----------------R-----DYIDC-F---LAEM-----------------EKLKDD---------------------------TAAGFDVENLCICTLDLFVAGTETTSTTLYWGLLYIIKYPEIQAKVQQEIDAV--V-G--------------------------------------------------------------GSR----------QPSVSD-RDNMPYTNAVIHEIQ-RMGNIVPLNVFRITVEDTQI-GE--YSIPK------G-----------TLVIGSLTS-VLFDESEWETPHSFNPG------HF--LDA--EG--KFR------R--RDAFLPFSLG-----------KRVCLGEQLAR-MELFLFFSSLLQRFTFS----PPAG---VEPSLDYKL--------G--GTHSPQ----PYKL--C--A-----VPR--- Danio_rerio_CYP2P10 ------NFPPG------------P-WSLPFIGDL----------HHI-----DPNKI------H-LQFTEFAE-----KYGKI--FSFRLFGSRIVV-LNGYNLVKEVYTQ--QG---DNLADRPTLPITS-AI--I-GDNRG---LVASSGYK-WKHQRRFALTTLRNFGLGK-------KNLELSINFECGFLNEAISNE-----------QGR--P-----FNPRLLLNNAVSNVICVLVFGNRFE----YSDHH------FQNLL----NKINESVYLEGSIFVHLY--NMFPWLMQ-LLPGP----HKKLITLW--QRVTDFVREKVNEHRVDYDPSSL----------------R-----DYIDC-F---LAEM-----------------EKHKDD---------------------------TAAGFDVENLCMCTLDLFVAGTETTSTTLYWGLLYMIKYPEIQAKVQQEIDAV--V-G--------------------------------------------------------------SSR----------QPSGSD-RDNMPYTNAVIHEIQ-RMGNIIPLNVVRTTSEDTRI-EK--YSIPK------G-----------TLVIGSLTS-VLFDESEWETPHSFNPG------HF--LDA--EG--KFR------R--RDAFLPFSLG-----------KRVCLGEQLAR-MELFLFFSSVLQRFTFS----PPAG---VEPSLDFKM--------G--FTRCPK----PYKL--C--A-----VPR--- Danio_rerio_CYP2P8 ------NFPPG------------P-WSLPIIGDL----------HHI-----DNSKI------H-LQFTKFAE-----RYGNI--FSFRLFGPRIVV-LNGYNLVKEVYIK--QG---DNLADRPVLPLFY-EI--VGD--KG---LILSSGYK-WKHQRRFALSTLRNFGLGK-------KSLEPSINVECGFLNEAISNE-----------QGR--P-----FDPRLLLNNAVSNVICVLVFGNRFD----YSDHH------FQTLL----KNISEAVYLEGSICNQLY--NMFPWLME-RLPGP----HKTIITLW--RKVTDFVREKVNEHRVDYDPSNP----------------R-----DYIDC-F---LTEM-----------------EKLKDD---------------------------TAAGFDVENLCICSLDLFVAGTETTSTTLYWGLLYMIKYPEIQAKVQEEIDAV--V-G--------------------------------------------------------------GSR----------QPSVSD-RDNMPYTNAVIHEIQ-RMGNIAPINLARSTSEDTQI-GN--YSIPK------G-----------TMVTSNLTS-VLFDESEWETPHSFNPG------HF--LDA--EG--KFR------R--RDAFLPFSLG-----------KRVCLGEQLAR-MELFLFFSSLLQRFTFS----PPAG---VEPSLDYKM--------G--GTHCPK----PFKL--C--A-----VPR--- Danio_rerio_CYP2P9 ------NFPPG------------P-WSLPIIGDL----------HHI-----DNSKI------H-LQFTKFAE-----RYGNI--FSLRLFGPRIVV-LNGYNLVKEVYIK--QG---DNLADRPVLPLFY-EI--IGD--KG---IVLSSGYK-WKHQRRFALSTLRNFGLGK-------KSLEPSINLECGFLNEAISNE-----------QGQ--P-----FDPRLLLNNAVSNVICVLVFGNRFD----YSDHH------FQTLL----KHINEAIYLEGGICAQLY--NMFPWLMQ-RLPGS----HKKVITLW--KKVIDFIRQKVNEHRVDHDPLNP----------------R-----DYIDC-F---LAEM-----------------DKLKDD---------------------------TAAGFDVENLCICTLDLFVAGTETTSTTLYWGLLYMMKYPGIQAKVQEEIDRV--V-G--------------------------------------------------------------GSR----------QPSVSD-RDNMPYTNAVIHEIQ-RMGNIIPINVTRTTSEDIRI-GK--YSVPK------G-----------TMVTSNLTS-VLFDESEWETPHSFNPG------HF--LDA--EG--KFR------R--RDAFLPFSLG-----------KRVCLGEQLAR-MELFLFFSSLLQRFTFS----PPAG---VEPSLDYKL--------G--ATHCPQ----PYQL--C--A-----VPR--- 'Takifugu rubripes CYP2P-like' ------NFPPG------------P-WPLPLIGDL----------HRI-----NPSRL------H-LQFAEFAG-----KYGNI--FSLRLFGGRVVV-LNGYKTVREALVE--KG---ENFVDRPLIPLFE-AF--A-G-NRG---LVISNGNP-WKHQRRFALHTLRNFGIGK-------KSLEPSIQQECHYLAEAFAQH-----------KGE--P-----FYAKALIHNAVSNIICCLVFGERFE----YSDKQ------YHAIL----KSFDRIIQLQGHFIVQVY--NTFPWLLK-WLPGT----HQTIFSEI--KTVINFVDLKIQEHKRNFDPSSL----------------R-----DYIDC-F---LAEM-----------------GEKEDV----------------------------ESGFDMKNLSICTMDLFGAGTETTTTTLQWGLLYMIYYPHIQEKVYAEISAV--I-G--------------------------------------------------------------SSR----------EPSITD-RDNMPYTNAVIHEMQ-RMANIIPLNVVHMASSDTTI-GN--YTIPK------G-----------TIIMPTLNS-VLHDESMWETPHSFNPQ------HF--LDQ--DG--KFR------K--REAFLPFSAG-----------KRVCLGEQLAR-MELFLFFTSLLQRFSFS----MADG---EQPSLDFQL--------G--GARFPK----PYRL--R--A-----ILR--- Kryptolebias_marmoratus_CYP2P19 ------NFPPG------------P-WALPFIGDL----------HRI-----QPSRL------H-LQLVQFTE-----KYGKV--FSLRLFGGRVVV-VNGYKLVKEALVQ--QG---EDYTDRPVIPMFQ-EI--A-G-NKG---LLLSNGYP-WRQQRRFALQTLRNFGLGK-------KSLELSIQQECQYLTDVFADQ-----------QGH--P-----LNALTLINNTVSNIICCLVFGNRFE----YTDEQ------YHEIL----HKFNEIVYLEGSAWAQIY--NVLPWLMR-WLPGP----HQKLFSLF--RDVIDFIEIRIKEHRENLDPSSP----------------R-----DYIDS-F---LIEM-----------------SENQDK----------------------------ESGFNLKNLCFCVLDLFGAGTETTTTTLHWGLLYMIYYPHIQERVQAEIDAV--I-G--------------------------------------------------------------PSR----------QPSISD-REDMLYTDAVIHEIQ-RMGNILPFNVAHMANKDTNL-DK--YSIPK------G-----------TIVLPMLHS-VLHDESIWETPHSFNPQ------HF--LEP--DG--KFR------R--REAFIPFSVG-----------KRVCLGEQLAR-MELFLFFTSLLQRFKFS----SPAG---EQPSLDFKL--------G--ASHCPK----PYRL--C--A-----VPR--- Kryptolebias_marmoratus_CYP2P20 ------NFPPG------------P-WALPFIGDL----------HRI-----QPSRL------H-LQLTEFAE-----KYGKV--FSLRLFGGRVVV-VNGYKLVKEALVQ--QG---EDYTDRPVIPMIQ-EI--FGN--TGGVCISVTNGYQ-WRQQRRFALQTLRNLGLGN-------KTLEQSTQQECQFLTEAFADQ-----------QGQ--P-----FKALTLINNAVSNVISCLVFGNRFE----YTDKQ------YQTIL----QDLSDLVYLEGSVWAKFY--NTAPWLMK-WLPGP----HQKIFSVA--QEITDFIEIRIKEHKQNLDPSSP----------------K-----DYIDS-F---LVEM-----------------AKNQDK----------------------------DSGFNLNNLCFCVLELFGAGTEPNATTLHWGLLYMIHYPHIQERVQAEIDAV--I-G--------------------------------------------------------------PSR----------QSSLSD-REDMPYTDAVIHEIQ-RMGDVVPLNLPHMTNNDTIL-DK--YTIPK------G-----------TMVMPLLHS-VLHDESIWETPHSFNPQ------HF--LDP--DG--KFR------R--REAFIPFSVG-----------NRVCFGEQLAR-MELFLFFTSLLQRFKFS----SPAG---EQPSLDFKL--------G--ATRCPK----PYRL--C--A-----VPR--- Kryptolebias_marmoratus_CYP2P16 ------NFPPG------------P-RSLPFIGDL----------HRI-----NPSRL------H-LQLVEFAE-----KYGDV--FSLHFFGERAVV-VNGYKNVKEALVQ--QG---EDFIDRPAIPLFS-EFFINKG-------LVMSNGYP-WKVQRRFALHTLRNFGLGK-------KNLALYIQQECQYLTEAFAEQ-----------QGK--P-----FNAQLLIHNAVSNIICCLVFGSRFE----YSDKQ------YQTIL----HYFNQIIQLQGAFSVQIY--NAMPSLMT-WIPGP----HKKIFRLI--QKLMDFVEIRIKEHRENLDPSSP----------------R-----DYIDA-F---LIEM-----------------GEVKDK----------------------------DSGFDLNNLCACTLDLFGAGTETTTTTLHWGLLYMIYYPHIQERVQAEIDAV--I-G--------------------------------------------------------------PSR----------QPSISD-REDMPYTDAVIHEIQ-RMGNIIPLNLPRIANKDTNL-DK--YSIPK------G-----------TIIIPLLHS-VLHDETMWETPHTFNPQ------HF--LDK--DG--KFR------K--REAFMPFSAG-----------KRVCLGEQLAR-MELFLFFTSFLQRFKFS----SPAG---EQPSLDFKM--------G--GTRLPK----PYHL--C--A-----VPR--- Kryptolebias_marmoratus_CYP2P17 ------NFPPG------------P-RSLPFIGHL----------HRI-----SASKI------H-LQFKEFAE-----EYGNI--FSLRLFGGRVVV-VNGYKLVKKALVQ--QG---EDFVDRPNVPVFN-EL--IKN--QG---LVGSNGYP-WKQQRRFALHTLRNFGLGR-------KSLERYIQQECQYLTEAFADH-----------KGQ--P-----FNAQKLINNAVSNIICCLVFGSRFE----YTDKQ------YHKIL----KDFNEIMYLEGSVWAQFY--NTAPWLMR-WLPGP----HQKIFTLT--QSIIDFIEIRIKEHRENLNPSSP----------------R-----DYIDS-F---LIEM-----------------QKHEDK----------------------------ESSFDLRNLCFCTLDLFGAGTETTTTTLNWGLLYMIYYPHIQERVQAEIDAV--I-G--------------------------------------------------------------PSR----------QPSVAD-RENMPYTDAVIHEIQ-RMGNILPLNVVHMANKNTTL-DK--YSIPK------G-----------TMILATLDS-VLRDETMWETPHTFNPQ------HF--LDK--DG--KFR------K--REAFMPFSAG-----------KRVCLGEQLAR-MELFLFFTSFLQRFKFS----APAG---EQPSLDFKL--------G--VTRCPK----PYCL--C--A-----VPR--- Kryptolebias_marmoratus_CYP2P18 ------NFPPG------------P-RSLPFIGHL----------HRI-----SASKI------H-LQFKELSE-----KYGNV--FSLRLFGGRVVV-VNGYKLVKEALVQ--QG---EDFMDRPQVPLFE-EL--VGN--NG---LVGSNGYP-WKQQRRFALHTLRNFGLGR-------KSLERYIQQECQYLTEAFADH-----------KGQ--P-----FNTQKLINTAVSNIICCLVFGSRFE----YTDKQ------YHKIL----QSLNEALYLEGSVWAQMF--NALPWLMK-WLPGP----HQKIFTLN--QELQEFTKIRIKEHRENLDPSSP----------------R-----DYIDA-F---LVEM-----------------EKNRDE----------------------------DSGFNLNNLCFCVVDLFVAGTETTTTTLIWALLYMIHHPHVQGRVQAEIDAV--I-G--------------------------------------------------------------PSR----------QPSLSD-RENMPYTNAVIHETQ-RMGNILPLSLGHMANRDTTF-EN--YTIPK------G-----------TIIITTLDS-VLHDESMWETPHAFNPQ------NF--LNK--DG--TFR------K--REAFMPFSAG-----------KRVCLGEQLAR-MELFLFFTSLLQRFKFS----SPAG---EQPSLDFKL--------G--ITRCPQ----PFRL--C--A-----VPR--- Oryzias_latipes_CYP2P15 ------NFPPG------------P-RSLPFIGDL----------HRI-----RPTIL------H-LQFKEFAA-----KYGNV--FSLNIFGGKTVV-LNGTKLLKEALIQ--KG---DDFVDRPQIPLFS-DL--IEN--KG---IVMTNGIQ-WKHQRRFALHTLRNFGLGK-------KTMEKYIQEECHYITQAFAEH-----------QGK--P-----FDAQPLLNSAVSNIICCLVFGERFE----YSDKE------YQQIL----QDLTEVVKLQGSFSALAY--NVFPWLMK-RFPGP----LQKLFTLV--DKIMDFVKIKIEEHKENLDPACP----------------K-----DYIDS-F---LIEM-----------------EKNQGE----------------------------DFGFDIKNLCACTLDLFGAGSETTTTTLYWGLLFMIHYPDIQEEVHAEIDAV--I-G--------------------------------------------------------------SSR----------QPSMAD-KENMPYTDAVIHEIQ-RMGDIVPIGVARMASRDTML-DN--YTIPK------G-----------TMIMPALHT-VLHDESVWETPHSFNPQ------HF--LNQ--DG--TFK------K--REAFFPFGAG-----------KRVCLGEQLAR-MELFLFFTSFLQRFSFS----TAGG---EKPPLEGRM--------G--TIRSPK----SYRL--C--A-----VPR--- Oryzias_latipes_CYP2P12 ------NFPPG------------P-HSLPFIGDL----------HRI-----QPARL------H-VQFTEFAE-----KYGNV--FSLHLLGERTVI-LNGYKQVKEALVQ--QG---DDFVDRPTIPLFV-DT--IDN--KG---IVMSNGNS-WKQQRRFALHTLRNFGLGK-------KTMETYIQNECHYITQTFADK-----------QGK--P-----FDAQFLINNAVSNIICCLVFGERFE----YSDQE------YQKIL----RNLNDLLILEGSVSAMLY--NMFPWLMK-RLPGP----HQKIFSLT--RKIIDFVKIKINEHKGNFDPSAP----------------E-----DYIDS-F---LIEM-----------------EKSQDK----------------------------DSGFDIDNMCICTMDLFLAGTETTTTTLYWGLLYMIYYPDIQEKVHAEIDAV--I-G--------------------------------------------------------------SSR----------QPSMAD-KESMPYTDAVIHEIQ-RMGDIVPQGVFRQANRDTTL-DK--YTIPK------G-----------TIIVPALHS-VLHDESMWDNPHSFDPK------NF--LDK--DG--KFC------K--REAFNPFGAG-----------KRVCLGEQLAR-MELFLFFTSLFQRFSFS----APTG---EQLSLESRM--------G--ATRCPK----PFRV--I--A-----APR--- Oryzias_latipes_CYP2P13 ------NFPPG------------P-HSLPFIGDL----------HRI-----NPSRL------H-LQLTEFAE-----KYGNV--FSLHLFGERAVI-LNGHKHVKEALVQ--RG---DDFVDRPSIPLFE-QFYSNKG-------IVVSNGYP-WKQQRRFALHTLRNFGLGK-------KTMEKYMQEECRYLTEAFGEY-----------KVK--P-----FNAQALINNAVSNIICCLVFGERYE----YSDKQ------YQQIL----QDINEIMILQGGFAAQLF--NSFPWLMK-KLPGP----HQKILTLL--AKLIDFAKVKISEHKENLDPSSP----------------K-----DYIDS-F---LIEM-----------------AQNENQ----------------------------ESSFDISNLCMCTLDLFIAGTETTTTTLHWGLLYMIYYADIQEKVQAEIDAV--I-G--------------------------------------------------------------SSR----------QPSMAD-KENMPYTDAVIHEIQ-RMGNILPLGVLRMASKDTTL-DK--YTIPK------G-----------TMIIPTLNS-VLHDESMWETPHSFNPK------HF--LDK--DG--KFR------K--REAFNPFGAG-----------KRVCLGEQLAR-MELFLFFTSLLQRFSFS----APAG---EQPSLENRM--------G--ATRCPK----PYRL--C--A-----VPR--- Danio_rerio_CYP2N13 ------KYPPS------------P-FSVPLLGNI----------FNV-----DSKEP------H-LYLTKLGH-----AYNNI--FSLRLGSDKTVF-ITGYKMVKEALVT--QA---ENFVDRPNSPVLA-RV--YSGN-AG---LFFSNGEM-WKKQRRFALSTLRNFGLGK-------KTMELAICEESRFLLEEIDEQ-----------KGA--A-----FDPTILLYNAVSNIICQMVFGQRFD----YADHQ------FKTML----KYISKSIQLEGSVWGQIY--EAFPAIMK-HLPGP----HNDIFSNY--DLLKSFVHEVIVKHKAKLDPSEP----------------R-----DYIDT-F---LIEM------------------KEKPL--------------------------ERVNGFEEPNLVACVLDLFLAGTESTSNTLCWGLIYLIMYPDVQEKVQEEIDRV--I-G--------------------------------------------------------------NSR----------EPSIAD-KPNMPYTEAVIHEIM-RFGDVIPLNGLRVAARDTTL-GE--CFIPK------G-----------TTVLPILHS-VLFDENEWETPYKFNPG------HF--LDK--EG--KFV------R--RDAFMPFSAG-----------KRVCLGEQIAR-IELFLFFVSLFRKFRFS----ATEG---EKLNMDGVI--------G--ITRTPH----PFKI--C--A-----TAR--- 'Takifugu rubripes CYP2N-like' ------NFPPG------------P-PALPLLGNI----------FNI-----EAKQP------H-LYLTKLAD-----VYGSV--FCIRLGRHKTVF-VSGWKMVKEAIVT--QA---DSFVDRPYSPMAT-RI--YSGNSAG---LFFSNGHV-WRKQRRFAMATLRSFGLAN-------GSMELSICEESRHLQEAMERQ-----------KGE--P-----FDPVPLLNNAVANIICQIVFGRRFD----YTDHM------FQRML----HHLTEMAYLEGSIWALLY--DSFPALMK-HLPGP----HNGIFSSS--SSLQGFIWREIQRHKSDLDPSNP----------------R-----DYIDA-F---LIEE----------------------------------------------GNGNNQLGFEERNLVLCCLDLFLAGSETTSKTLQWGLIYLIRNPHIQEKVQVEIDRT--I-G--------------------------------------------------------------RTR----------QPTMAD-RPNLPYTDAVIHEIQ-RMGNIVPLNGLRMTTKDTTL-GG--YLLPK------G-----------TSVMPNLTS-VLFDKNEWETPDTFNPE------HF--LDA--EG--KFV------R--REAFLPFSAG-----------RRACLGEGLAR-MELLLFFVSLCQRFHFS----TLDR---VELSTEGIT--------G--ATRTPY----PFKI--Y--A-----QVR--- Kryptolebias_marmoratus_CYP2N22 ------SFPPG------------P-LALPILGNI----------FNI-----ESKQP------H-IYLTKLAD-----VYGNV--FCIRLGRHKTVF-VSGWRMVKEALVT--KA---ENFVDRPYSPMVT-RI--YSGNSAG---LFFSNGKV-WRRQRRFAMATLRTFCVAK-------SSIEESVCEESQHLQQAMETE-----------EGE--A-----FDPIPFLNSAVSNIICQIVFGRRFD----YSDHD------FQSML----KNLTDMAYLEGSIWALLY--DAFPALMR-HLPGP----HNGIFSSS--KCLKASIRKEIKRHKLDLDPSNP----------------R-----DYIDK-F---LIQE-----------------RHNRKT----------------------------DVGFEEDNLVLCCLDLFLAGSETTSKTLQWGLIFLIINPHIQEKVRAEINSV--I-G--------------------------------------------------------------LTR----------PPSMAD-KPNMPYTDAVIHEIQ-RMGNIVPLNGLRMAAKDTTL-GG--YIIPK------G-----------TSVMPNLTS-VLFDKNEWETPGTFNPE------HF--LDE--EG--KFK------R--REAFLPFSAG-----------KRMCLGESLAK-IELFLFFVGLCQKFHFS----TLDG---VELSAEGIT--------G--ATRSPY----PFKI--I--A-----KP---- 'Oryzias latipes CYP2N-like1' ------HFPPG------------P-PALPVLGNI----------FSI-----DSKQP------H-IYLTKLAD-----VYGNV--FCIRLGRHKTVF-VTGWKTVKEALVT--QA---DNFVDRPYSPMVT-RI--YGGNSAG---LFFSNGSV-WKRQRRFAMTMLRTFGAAK-------SSTEQSICEESRHLLEAMEME-----------GGE--P-----FDPVPLLNKAVSNIICQIVFGRRFD----YSDTD------FQAML----TNLTDMAYLEGSVWALLY--DAFPALMK-YLPGP----HNSIFSSS--KSLETTIRREINRHKQDLDPSNP----------------R-----DYIDK-F---LMEE-----------------RHNRKI----------------------------HSGFEEENLVLCCLDLFLAGSETTSKTLQWGLIYLITNPHIQDKVQAEMDRV--V-G--------------------------------------------------------------HSR----------QPTTAD-RTNMPYTDAVIHEIQ-RMGNIVPLNGLRMAAKDTTL-GG--YIIPK------G-----------TAVMPNLTS-VLFDKTEWETPDNFNPE------HF--LDA--DG--KLL------R--KEAFLPFSAG-----------RRACLGEGLAR-MELFLFFVTLFQRFHFS----AAAG---VELRTEGII--------G--ATRTPH----PFQI--I--A-----KPR--- Oryzias_latipes_CYP2Z5 ------HFPPG------------P-PALPVLGNI----------FSI-----DSKQP------H-IYLTKLAD-----VYGNV--FCIRLGRHKTVF-VTGWKTVKEALVT--QA---DNFVDRPYSPMVT-RI--YGGNSAG---LFFSNGSV-WKRQRRFAMTMLRTFGAAK-------SSTEQSICEESRHLLEAMEME-----------GGE--P-----FDPVPLLNKAVSNIICQIVFGRRFD----YSDTD------FQAML----TNLTDMAYLEGSVWALLY--DAFPALMK-YLPGP----HNSIFSSS--KSLETTIRREINRHKQDLDPSNP----------------R-----DYIDK-F---LMEE-----------------RHNRKI----------------------------HSGFEEENLVLCCLDLFLAGSETTSKTLQWGLIYLITNPHIQDKVQAEMDRV--V-G--------------------------------------------------------------HSR----------QPTTAD-RTNMPYTDAVIHEIQ-RMGNIVPLNGLRMAAKDTTL-GG--YIIPK------G-----------TAVMPNLTS-VLFDKTEWETPDNFNPE------HF--LDA--DG--KLL------R--KEAFLPFSAG--------------------------VLVWARALPGWSSS-----------CFSSLYFRG-----------FIFRRQ----QEWS--C--------VQKE-- Kryptolebias_marmoratus_CYP2N23 ------NFPPG------------P-RPFPFVGNI----------VGL-----DSKQP------Q-NYFAKLAK-----AYGNV--FTVRFGRDTTVI-VWGYKMVKEAIVT--QA---ENFVDRPYNALAD-RI--YSQQEAG---VFMSNGEK-WRRQRRFALSTLRTFGLGK-------STLEQSICEEVRYLQEELERE-----------KGK--P-----FTPTGLFNNAVSNIICHLVMGKRFD----YSDHS------YQIML----KYMSEAVCLEGSIWGQLY--LAFPKVME-HLPGP----HNRIFSNY--NSILAFLNQEIEKHKKDLDPNNP----------------R-----DYIDT-F---LIEM-----------------KNHKDS----------------------------DLGFTETNLMMCSLDLFLAGTETTATTLMWALIYLIKNPDIQEKVQAEIDNV--I-G--------------------------------------------------------------QNR----------QPSMAD-RPNLPYTDAVVHEIQ-RFGNIVPLNGLRVAAKDTNL-GG--YFIPM------G-----------TSIMPILTS-VLFDKTEWETPDTFNPG------HF--LDA--NG--KFV------K--RDAFLPFSAG-----------KRVCLGEGLAK-MELFLFLVGLLQKFTFS----VPEG---VELDTEGIT--------G--FTRVPL----PYKV--Y--A-----KVR--- Oryzias_latipes_CYP2N18 ------NFPPG------------P-LGLPFVGNF----------LTI-----DGKHP------H-IYFSKMAE-----SYGNV--FSVRLGSQATVF-VSGYKMVKEALVT--QA---ENFVDRPFSEIGG-RF--YEGNSNG---LFFSNGEK-WKKQRRFALSTLRTFGLGK-------NTMEQSICEEIRHLQQQIENE-----------KGG--P-----FSPAGLFNNAVSNIICQLVMGKRFD----YDDNN------FQVMM----KYISEAVQLEGSIWGILY--ESFPGLMK-HLPGS----HNKIFRNY--KIVQDFLAQEIKIHKQDLDPNNP----------------R-----DYIDS-F---IIEM-----------------EKHQNS----------------------------DLGFNDANLAFCSLDLFVAGTETTSTTLMWALIYLIKHPDVQVKVQQEIDRV--I-G--------------------------------------------------------------QNR----------LPSMAD-RPNLPYTDAVVHEIQ-RIGNIVPLNGLRVAAKDTTL-GG--YFIPK------G-----------TALMPMLTS-VLFDKTEWETPDTFNPE------HF--LDA--DG--KFV------K--KEAFLPFSAG-----------KRVCLGEGLAR-MELFLFLVGLLQKFSFS----VPEG---VELSTEGIT--------G--TTRVPH----PYKV--Y--A-----KVR--- Oryzias_latipes_CYP2N20 ------NFPPG------------P-PGLPFVGNL----------LSV-----DGKHP------H-IYFTKLAE-----TYGNV--FSVRFGSETSVF-VSGYKMVKEALVT--QA---ENFVDRPYSPMAT-RF--YQGPTNG---IFMSNGEK-WKKQRRFALSTLRTFGLGK-------NTMEQCICEEIRHLQAEIESE-----------KGQ--L-----FTPTGLFNNAVSNIVCQLVMGKRFD----YNDHD------FHTMI----KYLSEVLRLEGSVWGLLY--EAFPGLMK-HLPGP----HNEMFKDF--DILRDFLDQEIKMHKKDLDRNNP----------------R-----DYIDS-F---LIEM-----------------EKHQNS----------------------------DLGFNEANLAFCSLDLFLAGTETTSTTLMWALIYLIKHPDVQVKVQQEIDRV--I-G--------------------------------------------------------------QNR----------LPSMAD-RPNLPYTDAVIHEIQ-RFGNIVPLNGLRVAAKDTTL-GG--YFIPK------G-----------TALMPMLTS-VLFDKTEWETPDTFNPE------HF--LDA--DG--KFV------K--KEAFLPFSAG-----------KRVCLGEGLAR-MELFLFLVGLLQKFSFS----VPEG---VELSTEGIT--------G--TTRVPH----PYKV--Y--A-----KVR--- Danio_rerio_CYP21A1 ------PTISG------------P-RSLPLLGNM----------LDL-----AQDHL------P-IHLTALAK-----CYGNI--YRLNCGSTTMVV-LNNSEIIREALVK--KW---SDFAGRPHSYTGD-IV--SRG---GRTISLGDFSEE-WKAHRRVTHSALQRCTTDS---------LHSVIEKQAQHLCQVLRDY-----------SGK--A-----VDLSEDFTVASSNVITTLTFSKAYD----KSSAE------LQKLQ----ECLNEIVSLWGSPWISAL--DSFPLLRK--FPNP---PFSRLMKEV--ARRDELIGKHIEEFKKSEHKEGG----------------------TLTSS-L---LKCL-----------------EPQQGA--------------------------ANHTTLTDTHVHMTTVDLLIGGTETIAALLNWTVAFLLHRPEVQDKVYEELCCM--L----------------------------------------------------------------DVR----------HPQYSD-RHKLPYLCALISEML-RLRPVAPLAVPHRAIRNSSI-AG--HFIPK------N-----------TIIIPNLYG-AHHDPEVWDDPYSFKPE------RF--LEG--GG--GSL------R----SLIPFGGG-----------ARLCLGEAVAK-MEMFLFTAYLLREFKFL----PASK-EEPLPELRGVA--------S--VVLKVK----PYTV--I--A-----HPRE-- Kryptolebias_marmoratus_CYP21A1 ------PTFPG------------P-PSHFLFGNM----------MEL-----THDHM------P-IHLTDLAQ-----RYGSI--YRLKFGNTTMVV-LSSGEAIREALVK--KW---SDFAGRPISYTGN-IV--SGG---GHNISLGDYTEE-WRAHRRVVHIALLRCCQQS---------LHGVIERQALHLRKVLLDY-----------HMK--P-----ADLSEDFTVAASNIITTLAFGKEYD----KKSTE------LQQLH----NCLNEIVGLWGSSWISAL--DSFPLLRK--LPNP---VFARLLKEV--ARRDEIIKHHLDDYKLQDKKNEH----------------------AITGS-L---LQAL-----------------DKHHNT------------------------E-HGGVLLTDVHVHMATVDLLIGGTETTSAWLNWTVAFLLHRPEVQTRVYEELCTV--L----------------------------------------------------------------EER----------YPKYSD-RHRLPVLSSLISEVL-RLRPVAPLAVPHRAIRDSSI-AG--YFIPK------N-----------TVIIPNLFG-AHHDPAVWPEPYSFKPE------RF--LEG--GG--GSA------R----ALMPFGGG-----------ARLCLGESVAK-MELFLFTAYLLRDFQFV----LPEG-EASLPDLRGVA--------S--VVLKIK----AYRV--V--A-----RPRPL- Danio_rerio_CYP17A1 ------RSPPS------------L-PSLPIIGSL----------MSL-----VSDSP------PHIFFQDLQK-----KYGDL--YSLMMGSHKLLI-VNNHHHAKEILIK--KG---KIFAGRPRTVTTD-LL--TRD---GKDIAFADYSST-WKFHRKMVHGALCMFGEGS-------VSIEKIICREASSMCEVLTES-----------QNS--A-----VDLGPELTRAVTNVVCALCFNSSYK----RGDAE------FESML----QYSQGIVDTVAKDSLV----DIFPWLQI--FPNK---DLRILRQCI--SIRDKLLQKKYEEHKVTYSDNVQ----------------R-----DLLDA-L---LRAK-----------------RSSENN-----------------------NSSTRDVGLTEDHVLMTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSK--I-G--------------------------------------------------------------KER----------HPQLSD-RGNLPYLEATIREVL-RIRPVSPLLIPHVALQDSSV-GE--YTVQK------G-----------TRVVINLWS-LHHDEKEWKNPELFDPG------RF--LNE--EG--DGL------CCPSGSYLPFGAG-----------VRVCLGEALAK-MELFLFLAWILQRFTLE----MPTG--QPLPDLQGKF--------G--VVLQPK----KFKV--V--A-----KVRAD- Kryptolebias_marmoratus_CYP17A1 ------QEPPH------------L-PALPLIGSL----------LSL-----RSPHA------PHVLFKELQK-----KYGQT--YSLMMGSHRVVI-VNQRVHAKEVLLK--RG---KVFAGRPRTVTTD-IL--TRD---GKDIAFGDYSAA-WRFHRKIVHGALCMFGEGS-------ASLERIISAEAQSLCQTMSEA-----------AAVGLP-----LDLSPELTRAVTNVVCSLCFNSSYC----RGDPE------FEAML----RYSQGIVDTVAKDS--LV--DIFPWLQI--FPNA---DLRLLKQCV--AIRDKLLQKKYEEHKADYSDHMQ----------------R-----DLLDA-L---LRAK------------RSAENNNTAEI------------------------S-AESVGLSDDHLLMTVGDIFGAGVETTTTVLKWAVTYLIHYPEVQRRIQEELDTK--I-G--------------------------------------------------------------VDR----------YPQLSD-RGSLPYLEATIREVL-RIRPVAPLFFPHVALSDTSI-GD--FKVRK------G-----------TRVIINLWS-LHHDEEEWDKPELFDPG------RF--LNS--EG--TGL------TVPSSSYLPFGAG-----------IRVCLGEALAK-MELFLFLSWILQRFTLS----VPPN--HSLPSLEGKF--------G--VVLQPV----KYKV--T--A-----TPRPG- Takifugu_rubripes_CYP17A1 ------RGPPR-----------LP--ALPLIGSL----------LSL-----RSPHP------PHVLFKELQG-----KYGQT--YSLMMGSHRVII-VNHHAHAKEVLLK--KG---KIFAGRPRTVTTD-VL--SRD---GKDIAFGDYSAT-WRFHRKIVHGALCMFGEGS-------ASIEKIICAEAASLCSILSEA-----------WTAGLA-----LDLSPELTRAVTNVICSLCFSSSYR----RGDAE------FEAML----HYSQGIVDTVAKDS--LV--DIFPCLQI--FPNA---DLRLLKRCV--SVRDKLLQKEYDKHKAAYSDHVQ----------------R-----DLLDA-L---LRAK------------CSAENNNTTGI------------------------N-AESVGLTDDHLLMTVGDIFGAGVETTTTVMKWAITYLIHHPQIQSRIQEELDSR--V-G--------------------------------------------------------------MDR----------SPQLSD-RGSLPYLEATIREVL-RIRPVAPLFIPHVALSDTSI-GD--FAVKK------G-----------TRVVINLWS-LHHDEKEWENPERFDPG------RF--LNS--EG--TGL------VIPSSSYLPFGAG-----------VRVCLGEALAK-MELFLFLSWILQRFTLT----VPSG--HSLPSLEGKF--------G--VVLQPT----KYKV--N--A-----TPRPG- Danio_rerio_CYP17A2 -------SFPC------------L-PRLPLLGSL----------LHL-----RSNLP------PHLLFTQLSS-----QYGPL--FGLYAGPHLTLV-VSEIGLVREVLLQ--RG---REFAGRPKMVTTD-LL--TQG---GKDIAFADYSPL-WKNHRRLVHSSFTLFGEGS-------NKLQTIVQEAADSLCEELQAC-----------RGQ--S-----SDLSVVLMRAVTNVICRLVFSSSYQ----PSDPE------LQTVI----QYNDGIVQTIARGGLV----DIFPWLRI--FPNK---DLKRLKECV--SIRDQLLYKKLLEHKKSLTPGEP----------------R-----DLLDA-L---LIGQ-----------------QRGSGG----------------------------ADDITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDEC--V-G--------------------------------------------------------------VDR----------PPCLSD-RPHLPLLDAVLCEVM-RIRPVSPILIPHVAMQDTSL-GG--HSVPK------G-----------TRVLVNMWA-IHHDPKHWDQPEQFNPE------RF--LEP--SG--KKK------T--QSSFLPFGAG-----------PRVCVGESLAR-IELFLFVSRPLQRFSFS----CPSE--ASLPDLQGRF--------G--VVLQPE----RYTV--T--V-----TPRH-- Takifugu_rubripes_CYP17A2 ------VKVPC------------I-SWVPVLGSL----------PWL-----RGGRP------LHLIFTQLSY-----RYGPL--FALYLGPHLTVV-VNNHQHAREVLLL--RG---KDFAGRPRMVTTD-LL--TRG---GKDIAFSDYCPL-WKSHRRLVQNSFTLFGEGT-------SRLQDMVLAAVDSLCEELLSM-----------EGR--G-----FDPAPAVTRAVTNVVCMLVFSATYR----HGDSE------LQEVL----RYNDGIVQTIAG--GGLV--DIYPWMKV--FPNK---TLSKLKACI--AVRDRLLTHKLEEHKATLTDNQP----------------R-----DLLDA-L---LMGQ------------VGRGRRKGSGR--------------------------VEEDIITEDHVLMTAAEAFGAGVETTSTTLLWILAYLLHHPQVQERVQKELDDH--V-G--------------------------------------------------------------SER----------PVRVSD-RARLTYLDCVINEGM-RIRPVSPVLIPHTAMTDSSI-GG--HHISR------G-----------TRVLVNMWS-IHHDSAHWDKPDLFNPD------RF--RDH--QG--QRV------T--PSCFLPFGAG-----------PRVCVGESLAR-LELFLFLSSLLQRMSFR----LPNG--ASPPDLQGRM--------G--VVLQPV----PYKV--V--V-----TPRVG- Kryptolebias_marmoratus_CYP17A2 ------ASIPC-----------LP--HLPVLGSL----------PWL-----GGGLP------PHLLFTQLGH-----RYGPL--FALFVGPHLTVV-VNDHRHAREVLLQ--RG---RDFAGRPNMVTTS-LL--TRG---GKDIAFSDYSAL-WKLHRRLVHNSFSLFGEGS-------SRLQDIFLSSVDSLCVELLSN-----------GTR--G-----FDPSPAVTRAVTNVVCTLVFSGTYR----HGDSE------LQEVI----RYNNGIVETIAR--GGLV--DIYPWMKF--LPNS---SLSKLKECI--AVRDKLLSRKLEEHKASLSDGDP----------------H-----DLLDA-L---LKGQ------------TGNGRGQKSHG--------------------------SEEEGITDDHVLMTAAEAFGAGVETTSTTLLWILAYLLHHPEVQERVQKELDEH--V-G--------------------------------------------------------------SER----------AVSMSD-RSQLPYLECVINEGM-RIRPVSPVLIPHTALTDSHI-GG--HAVTR------G-----------TRVLVNMWS-IHHDAQHWDRPDLFHPD------RF--LDD--QG--QRA------T--PSCFLPFGAG-----------PRVCVGESLAR-LELFLFLSSLLQRMSFK----LPDG--VSPPNLQGRL--------G--VVLQPL----PYKV--M--V-----TPRPG- Oryzias_latipes_CYP17A2 SLPPARSSIPC-----------LP--QLPILGSL----------PWL-----GGGLP------PHLLFTKLAH-----RYGSL--FGLFLGPHYTVV-VNSHQHAKEVLLQ--RG---RDFAGRPSMVTTE-LL--TRG---GKDIAFSDYSPL-WKLHRRLVHNSFTLFGEGT-------SRLQDVVFSAVDSLCSELMSN-----------GSR--G-----FDPSAAVTRAVTNVVCTLVFSSTYR----HGDAE------LQEVI----SYNNGIVETIAR--GGLV--DIYPWMKV--FPNS---SLRKLKECI--AVRDRLLTRKLEEHKASLAEGDP----------------S-----DLLDA-L---LKGK-----------------KGGPKS------------------------HGLEGEGITDDHVLMTAAEAFGAGVETTSTTLLWILAYLLHHPEVQQRVQKELDEN--V-G--------------------------------------------------------------ADR----------AANLSD-RGHLPYLDCVINEGM-RIRPVSPVLIPHTAMTDSSI-GG--HAVRR------G-----------TRVLVNMWS-IHHDPQNWDKPDLFQPE------RF--LDD--QG--NRA------T--PSCFMPFGAG-----------PRVCVGESLAR-MELFLFLSSLLQRMSFR----LPEG--APPPNLQGRL--------G--VVLQPM----PYEV--V--V-----IPRPG- Kryptolebias_marmoratus_CYP46A1 ------DKIPG------------PPRSSFLMGHS----------LML-LRIVNSDRL------VHEQFLEWAE-----TYGSV--YRLNGLHYVYLI-VTCPKATKEILMS--SKYLKDNF-YKKIFHLFG-----ERFVGNG---LITAQNHELWYKQRRIMDPAFSSLYLRG---------LIGTFNERAEKLMDKLADA-----------ADNNTE-----ANMLHLLNCVTLDVIAKAAFGADLDLLT-NKSPI------PKAIE----ACLKAIMNLVREPAFEFN-----PKNRQ---------FIKEVRKAC--RLLRTTGAQWIQKRKTAMQNGED--------------VPK-----DILTQ-----IIKT-----------------AATDEN----------------------------MTEEDEELMLDNVVTFFIAGQETTSGKLSFCIMELGRHPEILEKVRKEVDDV--I-G--------------------------------------------------------------MKQ----------DISYDD-LGKLVYLSLVLKETL-RIYPTAP-GTSRQIEEDMVI-DG--VHIPG------G-----------ISCIFDFYV-TGRLERFFKDPLKFDPD------RF--HPDVTKP--------------YYCHYPFSLG-----------PRSCLGKNFAQ-MEAKVVMAKLLQRFDFS----LVPG---QTFDIQDTG------------SLRPK----SGVI--C--S-----IKHRK- Kryptolebias_marmoratus_CYP46A2 ------DHIPG------------PPRDSFFLGHS----------PTL-----KRIMKNDEL-VH-DKLIEWSE-----TYGSV--YRLNVLHFVVVC-VTCPEATKEILMS--PKYLKDKFVYKKLYNLFGQRF-------FGNGLVTVQNHEL-WYKQRRIMDPAFSTLYLRG---------LIGTFNERAEKLMDKLADA-----------ADNNTE-----ANMLHLVNCVTLDVIAKVAFGMDLDLLT-NSSPF------PKAIE----TCLNAMVYYIRDLTFEFN-----PMNRR---------FIKEAREAC--RLLRTTGARVIRERKTAMQNGED--------------VPK-----DILTQ-----IIKT-----------------AATEET----------------------------MTEEDEEFMLDNFVTFFIAGQETTANQLAFCIMELGRHPEILEKVRKEVDDV--I-G--------------------------------------------------------------MKQ----------DLSYED-IGKLTYLSQVLKETL-RMYSTVP-GISREIQEDMVI-DG--VHIPG------G-----------VSCMLNSYV-SGRLERFFKDPLKFDPD------RF--HPDAPRP--------------YYCYYPFALG-----------PRACLGQNFAQ-MEAKVVMAKLLQRFDFS----LVPG---QTFEIRDTG------------MLRPK----SRVV--C--S-----IKHRK- Kryptolebias_marmoratus_CYP46A4 ------DHIPG------------PPRDSFLFGHS----------PTI-----LKTMLNDKN-LH-DKFLEWSE-----TYGLV--YRVNALHYVFLI-VTCPEATKEILMN--QKYPKDKFTYKKISHLFG-QR--FLG--NG---LVTAHEHEVWYKQRRVMDPAFNNLYLRG---------LMGTFNERAEILMDKLVDV-----------ADNNTK-----ANMLHHFNCITLDVIAKVAFGMELDLLK-NSSPL------PKAIE----TCLKGMVFYIRDFFFQFN-----PKNRR---------FIKEVREAC--RLLRTTGAQWIQRRKTAMQNGED--------------VPK-----DILTQ-----IIKT-----------------AATEET----------------------------MTEEDEEFMLDNFVTFFIAGQETTANQLAFCVMELGRHPEILEKVRKEVDDV--I-G--------------------------------------------------------------MKQ----------DISYDD-LGKLVYLSQVLKETL-RIYPTAP-GTSRQIEEDMGI-DG--VHIPG------G-----------ISCIFDSYV-SGRLERFFKDPLKFDPD------RF--HPDAPKP--------------YYCYYPFSLG-----------PRSCLGKNFAQ-MEAKVVMAKLLQRFDFS----LVPG---QTFDIQDTG------------SLRPK----SGVI--C--S-----IKHRN- Kryptolebias_marmoratus_CYP46A5 ------DHIPG-----------PP-RDSFIFGHS----------ATL-----SRIMKSGGNVH--EKFLEWSE-----TYGPV--YRINGLHLVTVC-VTCPEATKEILMS--PKYPKDKFVYNRLFGLFGRRF-------FGLGLITAQNHEL-WYKQRRIMDPAFSSLYLRG---------LMGIFNERAEKLMDKLTEF-----------ADNKTE-----ANMLHLLNCVTLDVIAKVAFGMDLDLL--QKSSP------FPKAI----ELCLKGMVYYARDLFFEY----NPKNRR---------FVKDVREAC--DLLRTTGAQVIQKRKTAMQNGED--------------VPK-----DILTQ-----IIKT-----------------AATEEN----------------------------MTKEDEEFMLDNFVTFFIAGQETTANQLGFCVMALGRHPEILEKVRKEVDDV--I-G--------------------------------------------------------------MKQ----------DISYDD-LGKLVYLSQVLKETL-RIYPTAP-GTSRQIEEDMVI-DG--VHIPG------G-----------ISCMFDSYV-TGRMERFFKDPLKFDPD------RF--HPDAPKP--------------YYCYYPFALG-----------PRSCLGQNFAQ-MEAKVVMAKLLQRFDFT----LVPG---QTFDIQDTG------------TLRPK----SGVI--C--Y-----IKHRK- Danio_rerio_CYP46A1.3 ------DHIPG------------PPRDNFLLGHI----------PTI-----NRVTKSERH--MNDLLLIWAE-----KYGPV--YRLNSFHYVIIN-VHCPEATKTIMMS--PKYLKDPFIYKRLFGLFG-----KRFLGYG---LVTATDHDIWYRQRRIMDPAFSSSYLRG---------LISTFNEMSERLMDKLEEM-----------AINKTP-----AVMHDLVNCVTLDIICKVAFGVDLNLFKQTDNPF------QQAIE----QCLQGMVLDLRDPFCKFF---PKNWKAI-----------QETKGAT--VLLRKTGEQWIQNRKTAVEIGED--------------VPN-----DILTQ-----ILKT-----------------AKEEKV----------------------------NNTKDHEQMLDNFVTFFIAGQETTANQLSFAIMELGRHPEIYKRAKAEVDEV--L-G--------------------------------------------------------------TKR----------DISYED-LGKFTYLSQVLKETL-RLYPTAP-GTNRWLHEDMVI-NG--IKIPG------G-----------ISVIFSSYV-AQRLEKHFKDPLKFDPE------RF-NVNA---------------PKPYYCYYPFSLG-----------PRSCLGQVFSQATPAEGALAQLLTQLLTL-----------CSHFLIVLY-----------FSKSSG----HASL----------------- Danio_rerio_CYP46A1.1 ------DHIPG------------PPRDSFLLGHS----------SSL-----TKAVYSDNNLIH-DLFLHWAE-----KYGPV--YRINTLHYVTIM-VYCPEATKTIMMS--PKYIKDPFVYKQLFNLFG-KR--FLG--NG---LITAVDHDMWYRQRRIMDPAFSSTYLRS---------LISTFDEMSERLMDKLEEM-----------ANNKTP-----AVMHDLVNCVTLDVICKVAFGVDLNLLNQKDSPF------QNAVE----LCLKGMILDVRDPFFRLF---PKNWKLI-----------QQVREAT--ELLRKTGEKWIQNRKTAVKNGED--------------VPK-----DILTQ-----ILKS-----------------AEEENV----------------------------NNTQDLEQMLDNFVTFFIAGQETTANQLSFAIMALGRNPEIYKRAKAEVDEV--L-G--------------------------------------------------------------TKR----------EISNED-LGKLTYLSQVLKETL-RLYPTAP-GTNRWLHEDIVI-NG--IKVPR------G-----------CSVMFSSYV-SQRLEKFFKDPLKFDPE------RF---DV--NA-----------PKPYYCYYPFSLG-----------PRTCLGQVFAQ-MEAKLVLAKLLQRFEFS----LVPG---QSFDIKDNG------------TLRPK----SGVI--C--N-----IKQCS- Danio_rerio_CYP46A1.2 ------DHIPG------------PPRDNFLLGHS----------PSL-----TKAMYSDDSLIH-DLFLQWAE-----QYGPV--YRINTLHYIAIV-VHCPEATKTILMS--PKYAKDPFSYSRLFNLFG-KR--FLG--NG---LVTAVDHDIWYRQRRIMDPAFSSSYLRS---------LISTFDEMSERLMDKLEEM-----------ANNKTP-----AVMHDLVNCVTLDVICKVAFGVDLNFLTQKDSPF------QNAIE----LCLNGMALDARDPLFRIF---PKNWKLI-----------QQIRDAA--VLLRKTGEKWIQNRKTAVKNGED--------------VPK-----DILTQ-----ILKI-----------------AEEENV----------------------------NSSEDLEQMMDNFVTFFIAGQETTANQLSFAIMALGRNPEIYKRAKAEVDEV--L-G--------------------------------------------------------------TKR----------EISNED-LGKLTYLSQVLKETL-RLYPTAP-GTNRWLHEDMII-NG--IKIPG------G-----------CSVMFSSFV-SQRLEKFFKDPLKFDPE------RF---DE--NA-----------PKPYYCYYPFALG-----------PRTCLGQVFSQ-MEAKVVLAKLLQRFEFS----LVPG---QSFDIKDTG------------TLRPK----SGVI--C--N-----IKQCS- Danio_rerio_CYP46A1.4 -------------------------ADDSLIHDL---------------------------------FLQWAE-----KYGPV--YRINSLHYIAIV-VHCPEATKTILMS--PKYTKDPFVYRRLFNLFG-KR--FLG--YG---LITAVDHDIWYRQRRIMDPAFSSSYLRS---------LISTFDEMSERLMDKLEEM-----------ANNKTP-----AVMHDLVNCVTLDVICKVAFGVDLNFLTQKDSPF------QNAVE----LCLNGMTVDLRDPFFRLF---PKNWKLI-----------KQIRDAA--ELLRKTGEKWIQNRKTAVKNGED--------------VPK-----DILTQ-----ILKS-----------------AEEENV----------------------------NNTDDLEQMLDNFVTFFIAGQETTANQLSFAIMALGRNPEIYKRAKAEVDEV--L-G--------------------------------------------------------------TKR----------EISNED-LGKFTYLSQVLKETL-RLYPTAP-GTNRWLHEDMII-DG--IKIPG------G-----------CSVMFSSYV-SQRLEKFFKDPLKFDPE------RF---DV--NA-----------PKPYYCYFPFALG-----------PRTCLGQVFSQ-MEAKVVLAKLLQRFEFS----LVPG---QSFDIKDTG------------TLRPK----SGVI--C--N-----IKQCS- Danio_rerio_CYP5A1 ------CGIKH------------P-KPLPFIGNL----------MMF-----RNGFF--------KSQADLIN-----KYGRI--CGYYIGRRSTVI-IADPDMLRQVMVK--EF---NKFPNRMTARGITKPM--SDS-------LIMLKGEQ-WKRVRSILTPTFSAAKMKE---------MVPLINTATETLLRNLKSH-----------AESENS-----FNIHKCFGCFTMDVIASVAFGTQVDSQNNPDDPF------VH-------QASKFFAFSFFRPIMIFF--MAFPFLLR-LLAGL---LPNKSRDEM--NSFFTQCIQKMIKQRDDLSPEQR----------------RK----DFLQL-M---LDVR------------TNKKFLSVEHFDVVNDADEEAYDGHENSPANESTKRSQQKRMMTEDEIVGQSFIFLVAGYETSSNTLAFTCYLLAVHPECQKKLQEEVDEF--F-S--------------------------------------------------------------RHE----------TVDYAN-VQELKYLDMVICESL-RLYPPAF-RVARDVEEDTVL-NG--QFLPK------G-----------ASLEIPTGF-LHYDPEHWTEPTKFIPE------RF--TPE--AK--ARR------H--PFVYLPFGAG-----------PRSCVGMRLAQ-LEIKVALVHIFRRFNVL----ACED---TEIPLELKS-------HT--TLGPKN----GVMV--K--I-----TEREN- Kryptolebias_marmoratus_CYP5A6 ------CGIKH------------P-KPVPFFGNM----------LMF-----REGFY--------KPLIDIVK-----THGKV--CGYYFGRKPVVM-IADPDVLRKVMVK--DF---SSFANRSNGYSTK-PF--EDC-------LIMLKDEQ-WKRVRSIVTPSFSAAKLKE---------MVPFISTATDTLMNNLNVH-----------AESGEA-----FDIHKCFGCFTMDVIASVAFGTQVDSQNNPNNSF------VRNTL----EFLAMPFFRPLVVVSFLFPAIMAPFVRF--VPNK------KRIELD--NFFISIIHKIIMQREEQPPDQRR----------------R-----DFLQL-M---LDARNSQESVSLEHFDTTKHSDELDDK--NQQKQSAVDQENGHLRSEESLMRCSQRKMMTEDEIMGQAFIFLVAGYETTSNTLAYTCYLLALHPECQRKVHEELDDF--F-T--------------------------------------------------------------RHD----------SPDYTN-IQELKYLDMVVCEAL-RLYPSIF-KITREVANDYMI-KG--QLIPK------G-----------AKVEILTCF-LHQDPEHWPEPEKFIPE------RF--TPE--AK--ANR------H--PFVYLPFGAG-----------PRNCVGMRLAQ-LEIRMVLVHLLHRFNVV----ACSE---TKVPLNLKS-------NL--TLSPKN----GIYV--K--M-----TRRNE- Kryptolebias_marmoratus_CYP5A2 ------CGIKH------------P-KPVPFFGNM----------LMF-----RKGFF--------QPLSDIIK-----THGRV--SGYYFGRKPVVL-VADPDMLRQVLVK--DF---SSFPNRLVRFSNQ-SL--QED------CLLILRNER-WKRVRSVVTPTFSAAKLKD---------MVPLINTATDALMNNLSVH-----------ADSGKA-----FDIHKSFGHFTLDVIASVTFATQVD----SQNNP------DSPFV----RIAQMFISLSFFRPLTLFFTVLFPGILA---PFARFVPNKKREQMD--KIFISSFQALIKQREEQPPDQRR----------------R-----DFLQL-----MLDARSGQEAVSLEHFDTGNHSDELNSKSQQKQPSALNQDKNHSHSKDSLMNRPQKKTITEDEIVGQAFVFILAGYETSRSTLSFTCYLLALHPECQGKVQKEVDDL--F-T--------------------------------------------------------------RHD----------SPDYAN-IQELKYLDMVVCESL-RLYPPGF-RFAREVEHDCVV-NG--HFLPK------G-----------ANLEVPAGF-LHHDPEYWPEPEKFIPE------RF--TPE--EK--ANR------H--PFVYMPFGAG-----------PRNCVGMRLAQ-LEIRMALAHFFHRFSVT----TCSE---TKVPLELKS-------FG--TLGPKN----GVTV--K--I-----TRRDK- Kryptolebias_marmoratus_CYP5A3 ------FGIKH------------P-KPVPFFGNI----------LMF-----RKGFL--------KPVSDIIK-----THGRV--CGYYFGRRPRVL-VTDPDMLRQVLVK--DF---TYFPNRLVRFSTK-PL--EDS-------LLFLTNER-WKRVRSVITPTFSTAKLKE---------MVPLINTANNALMNNLSVH-----------AESEKA-----FDIHECFHYFTMDVIASVAFGTQLDS---LNNPD------HPLVR----HVQMFFASSFFRPLLLLY--ILFPSIMA-PFARL----IPKIKQAYLDKFFISSIKTIIKQREEQPPDQRR----------------R-----DFLQL-----MLDARTGQEAVSLEHFDTGNHSDELNYKSQKKQPSALNQENSHSPTEDSIMRHPQKKMMTEDEIVGQALLFFLAGYDTTSNALSFTCYLLALHPECQRKVQEEVDDF--F-T--------------------------------------------------------------RHD----------SPDYTN-IQELKYLDMVLSETL-RLYPPGF-RFVREVEHDCVV-NG--QFLPK------G-----------VTLEVPAGF-LHHDPEFWPEPEKFIPE------RF--TPE--AK--AKR------H--PFVYLPFGAG-----------PRNCVGMRLAQ-LEIRMALAHLFSRFNIV----SCSE---TKVPLDLKS-------FG--TLGPKN----GVFL--K--I-----TKRNK- Kryptolebias_marmoratus_CYP5A4 ------CGIKH------------P-KPVPFFGNM----------LMF-----REGFL--------KPLSEIVK-----THGKV--CGYYLGRKPMVV-IADPDILRQVMVK--DF---NNFTNRRFQLTTK-PW--KDC-------LLMLRNEQ-WKRVRSVVTPTFSAAKLKE---------MVPLINTATDALMNNLSVH-----------AESGKV-----FDIHKCFQCFTMDVIASVAFGTNLDSQNNPDDPF------VHYAQ----MFFAMSFFKPLVLFSILFSKIMAPLVRI--IPNK----RREEID----KFFISSIKKIIKQREEQPPDQRR----------------R-----DFLQL-----ILDARTGQESVSLEHFDTTKHSDELDNRSQQTPLPVSDQKISHPHIQKSSTGHLQKKTITEDEIVGQAFVFFLAGYETTSSTLGFACYLLALHPECQSKVQEEVDDF--F-T--------------------------------------------------------------RHD----------FVDYTN-VQELKYLDMAVCEAL-RIYPPGF-RFNREVYHDCVI-NG--QFFPK------G-----------ATLELFSGF-LHHDPEHWPEPKKFIPE------RF--TPE--AK--ANR------H--PFVYLPFGAG-----------PRNCVGMRLAQ-LEIRMALAHLFHRFSVV----SCSE---TKVPLDLKT-------FS--TTAPKN----GIFV--K--I-----TRRNV- Kryptolebias_marmoratus_CYP5A1 ------FRIRH------------P-KPVPFFGNL----------FMF-----REGFF--------KPLTDIIN-----THGRV--CGYYLGRRPIVV-IADPDMLRQIMVK--DF---SSFPNRMKFNFVTKPM--SDC-------LLMLRDEK-WKRVRSILTPSFSAYKMKE---------MVPLINTATDALMNNLNIH-----------AESGDA-----FDIHKCFGCFTMDVIASVAFGTQVDSQNNPDDPF------VRHAQ----MFFSFSFFRPLLLFFIAFPTIMAPIARY--IPNK----RRDLMSGF----FINIIQKIIKQREDRPPDQRR----------------R-----DFLQL-----MLDARNSQESVSLEHFDTANHSDEIDNQSQQTQPSTLDQEGNRPHPDESPVRHPQKKVMTEDEIVGQAFIFLVAGYETSSNTLGFTCYLLAINPECQRKVQEEVDDY--F-T--------------------------------------------------------------RHD----------SPDYTN-IQELKYLDMVVCEAL-RLYPPGF-RFAREVANDCVV-NG--QFLPK------G-----------VSLEIPVGF-LHYDPEYWPEPEKFIPE------RF--TPE--AK--ANR------H--PFVYLPFGAG-----------PRNCVGMRLAQ-LEIRMALTHLFHRFSVV----ACSE---TKVPLDLKS-------SS--TLGPKN----GVFV--K--I-----TRRER- Takifugu_rubripes_CYP3A30 ------LGISG------------P-KPTMYFGSI----------CKY-----NNVYY--------LDDQECAQ-----KYGKI--WGTYELRKPMLV-VMDPDLLKTILVK--ECF--THFTNRRNFCLNG-DL--YDA-------VNIAEDDD-WRRIRNVLSPLFTTGRIKQ---------IFSLMKRQSSKLTSSLEPK-----------AENEEI-----ISIKDFFGAYNMNVATGVLFGMEME----PSLPI---------------KHASKLFKFPIPLFMIQ---GCFPILLP-LLQLM----GFSLFP----RDSFAFVKKIVEKIRAERDGGSHQVCTGRTRMLTTYTSTEF----DFLQH-----MIST-------------------------------------------------QKNDGLTDHEIVSQLTVLLTGGYETSTLALTLSIYSLATNPGSMNRLQEEIDAT--F-P--------------------------------------------------------------DAA----------PVTYEA-LMQMEYVDCVINECL-RLYPPAA-RLERTAKETVEI-SG--ITIPK------N-----------MTVTVPIFA-LHRDPEHWPEPEEFKPD------RF--SKQ-NKG-----------RINPYTYLPFGIG-----------PRKCLGMRLAL-VIVKLALVETLQKYSFS----VCKE-TEIPFKMDPNT-----------FVGPIN----PIKL--R--V-----VRR--- Takifugu_rubripes_CYP3A27 ------NGIPG------------P-MPLPFIGTM----------WNL-----LKGNM--------VFDRECQS-----KYGDV--WGVFEGRTPVLM-VSDPGMIKTILVK--ECY--SVFTNHREIFSGPLET------------SVFSAKDETWKRMRTSISPCFTSGRLRQ---------AFPIIARYADRFIAKLEQT-----------KLEDST------DIKKLFGPYSLDVIASSSFSVDADSINNPDDPF------IINIK----KVLNLNFWLLLIK-------NVLPFSSY-LFEFL----HIDIIPRSIVDYFFNLIKQLKAQHDQSIKG-------------------------DFLHV-M---IQNE------------IPQSEIKSDQD--------------------------QPPKGLTEQEILSQSVLFIFGGYDTTTITITYLLYNLAINPDVLQILHSEIDSN--F-P--------------------------------------------------------------KDT----------PFSYED-LVGFQYLDQVLNESQ-RLIPTAP-ALERFCKKTVQI-HG--LTIPE------G-----------TVVAVPVHL-LHKDPRFWSSPEEFRPE------RF--SKD--NI--EEV------N--PYAFMPFGLG-----------PRNCIGMRYAI-LVMKMILVRVLQSYTVE----TCKD---TMIPLEFDW-----------KLQPTK----QIKL--R--L-----VPRQK- Kryptolebias_marmoratus_CYP3B10 ------LSISG------------P-RPLPFIGTM----------LGV-----RKGIF--------SFDRECQT-----KYGDV--WGLYEGRNPMLI-IADPELIKIVLVK--ECY--SAFTNRRDVIGMGGPL--EDA-------ITAVKDER-WKRIRSTISPCFTSGRLKQ---------VFPFIARFADRLVEKLGK------------KNLDEP-----IDIKQFMAPFSLDVVTSASFSVEID----SINNP------DDPVN----AHMQKMMKINFWPFLVLM---VFPFGRH-LLKLF----KIEMLPRPSVDFFYNIIKKFKDQHQAAESTRG-----------------------DFLQV-M---IQNE------------IPEADIKNEQE--------------------------QPSKGLTEHEILSQALMFIFAGYETTSTTLSLIFYNLATNPDVMQTLQDEIDAS--L-Q--------------------------------------------------------------KDT----------SISYTD-LSNLQYLDQVILESM-RLISTAP-RLERVCKKTVQI-NR--LTVPE------G-----------TLIGIPVQL-LHKDPRFWSSPELFKPE------RF--SKE--NE-AELN---------PYAYMPFGLG-----------PRNCVGMRYAI-LVMKMVIVRLLQSYTLE----TCKD---TMIPLEFNW-----------KFQPTK----PIKL--K--F-----APRIS- 'Oryzias latipes CYP3A56-like' ------LNIPG------------P-KPLPFVGTI----------FGV-----RKGLF--------AFDSECQA-----KYGDV--WGLYDGRSPVLM-VADPEMIKTIMVK--ECY--SVFTNRRDTEIPG-PF--EDG-------ITVVKDDR-WKRIRSTISPCFTSGRLKQ---------VFPIVASYADRLLKKLEQ------------TNLDEP-----IHVKQFVAPYSLDTVASASFSVEMDSINNSEDPV------NVHIQ--------KLFNINFWPFILLM---ICPFAGR-LLNSL----NIGMLPKAESDFFLNIIKKFKDQHKAGESTRQ-----------------------DFLQV-----MVQS-----------EIPENEIKNEQE--------------------------QPSKGLTEPEIVAQAFTFILGGYETTSTTLSFILYNLATNPHAMHTLQKEIDAN--L-Q--------------------------------------------------------------KNA----------SFSYEE-LNDLHYLDQVILESM-RVLPTAP-RLERGCKKTVEI-QG--FTIPE------G-----------TVVGIPVMN-LHKDPRYWSSPELFRPE------RF--SKE-NEG--ELN---------PYAYMPFGLG-----------PRNCVGMRYAI-LVMKMVIVRLLQNYTLE----TCKD---TLIPLQFDW-----------KFQPLK----PIKL--K--F-----VPRKQ- 'Oryzias latipes CYP3A40-like' ------LGISG------------P-MPLPFVGNV----------LQM-----GRDIL--------SFDRQCLD-----KYGDV--WGVFEGRQPMLM-VANPELVKAVMVK--ECY--SAFTNRRNFFPEDGPL--ADG-------VAVVKDEK-WKRIRSSLTPCFTSGRLKQ---------VYPLVARYAENLVKKLGRM------------NSDEP-----IDVRQFVAPYSMDVVASTSFSVDTDCINNPDDPV---------------NVQAQKATNFNFWPVILQ--TMIPFGDL-LLKLL----KFETLPRSNVDFFYDLIKRLRDQHKAGKLTRP-----------------------DFLQV-L---IDSE--------------IPQEHVKNE--------------------------QPSKGLTEHEVLSQAFGFVLAGYETMSNTLCFILYNLATNPDAMCTLQKEIDSN--L-Q--------------------------------------------------------------NDG----------SFSYEE-LSGLEYLDQVLCESM-RFFSPTP-RLDRECKKTIEI-HG--VTIPK------G-----------TLVAIPVSL-LHMDPRFWSSPEIFRPE------RF--SKE--NA-SELN---------PYAYMPFGLG-----------PRNCVGMRFAV-LVMKMVIVRLLQSYSLE----TCKD---TLIPMQYDW-----------QFQPIK----PIKL--K--F-----VPRKQ- Oryzias_latipes_CYP3B5 ------MGISG------------P-MPMPYVGNL------------L-----QQGKG------FFEFDHECQT-----KYGDV--WGVFEGRQPILM-VADPEIIKTVMVK--ECY--SAFTNRRNFFEGDGPL--TEA-------VASAKDEK-WKRIRSSLSPCFTSGRLKQ---------VFSIVSRYADRLVEKLGETY----------LNK--A-----IDIRQFVAPYTLDVVASASFSVDPDCINNPDDPI---------------NVQAQKATRFNFLPTILQ--SIIPFGGR-LLKLF----KIETLPSANVEFFIDIIRNLKDQHKTG-KMNRP----------------------DFLQV-L---IESE------------MPDAEIKNSQQ--------------------------QPSKGLTETEILSQALGFIVGGYDTTSTALSYIFYCLATNTDAMHTLQKEIDSN--L-Q--------------------------------------------------------------KNS----------SISYED-LNGLEYLDQVINESL-RLYPVAP-RLDRECKMTVET-QG--FTVPE------G-----------MIVGIPVYL-LHKDPRFWSSPELFRPERLFGLCRF--SKE--NE--GEL------N--PYAYMPFGLG-----------PRNCVGMRFAV-LMMKMIIVRLLQRYSVE----TCKY---TLIPMQFNW-----------MFQPIK----PVKL--K--F-----VPK--- Danio_rerio_CYP3C1 ------LGIPG------------P-RPLPFVGTA----------LSY-----SKGIC--------NFDIECSK-----KYGKV--WGIYDGRLPLLL-VTDLEMIKTILVK--DCY--STFTNRRNMNPDL-----VGPFADG---ITLVKDER-WRRIRSSLSPYFTSGRLKE---------IFPIAMTHADRFIKNMEK------------KDPNLP-----LKIKDVVAPYSLDVVASSSFSVDFDSINNPDDPF------VTSIK----SFFNIN---PLSPLFLLL--AFCPSAAN-LLAKM--GISVFSRSTT--DFYYKALRKIKDEHNESNGRV------------------------DFLKL-M---IQNQ------------IPDDQVKDTAS------------------------E-QPVKGLTDHEILSQSFIFILGGYETTSTTLSYLLYNLATNPDCLEKLVEEIDKN--F-P--------------------------------------------------------------LDI----------PITYDA-LMRMDYLEMAIHESM-RVFPAGP-RLERVCKKTVEI-NG--ITIPK------N-----------TLVGIPLYV-LSRDPDLWESPNEFKPE------RF--SPE--SK-TEIN---------QCAFMPFGLG-----------PRNCIGMRFAL-MMMKLLVVKLLQKYTVE----TCKE---TQIPVQLNF-----------FFQPKV----PITL--K--L-----IPRSH- Danio_rerio_CYP3C4 ------LGIPG------------P-RPWPFVGTL----------LSY-----AKGLC--------NFDMECAK-----KYGKV--WGIYDGRLPILM-VADLEVIKVVLVK--ECY--SNFINRRKRTTGL-----AGPFSDG---IIMVKDER-WKRMRSTLSPYFTSGRLKE---------IFPIAMTHADRFIKNMQK------------KDPEQP-----VKIKEVVAPYSLDVITSSSFSVDIDS---INNPE------DPFVI----NVKKFIQFNMFNPLLLLI--LLFPSLAI-PLKKM--GVTLFSKSAM--DFFYSVLKKIKDDHNKESEGRV-----------------------DFLKL-M---LQNQ--------------IPDDQIQDS----------------------DTSEQPAKGLTDHEILSQSLVFILGGYETTSTTLTFLLYNLATNPDCLEKLVEEIDKN--F-P--------------------------------------------------------------LDT----------PITYDA-LMRMDYLEMAINESM-RLLPTAP-RLERSAKKTVVI-NG--LTIPE------G-----------TLVGIPTYV-LSHDPDIWESPGEFRPE------RF--SPE--NK-SEFL---------QYAFIPFGLG-----------PRNCIGMRYAV-MIMKLFVVKLLQNFSVE----TCKE---TQIPLEMNV-----------TFQPKV----PITL--K--L-----IPRSC- Danio_rerio_CYP3C2 --------------------------------------------------------------------MECAK-----KYGKV--WGIYDGRLPILM-VTDLEMIKTIMVK--ECY--STFTNRREINVDL-----AGPLADG---ITAVKDER-WKRIRGTLSPYFTSGRLKE---------IFPIAMTHADRFIKNMQK------------GDHEQP-----VKIKEVMASYSLDVVTSSAFSVDIDSINNPDDPF------VTNIK-------NFLKFNLFGLFVLLL--TVFPSIAN-LLGKM----GLSMFSKPTVDFFYKALRKIKEEHKDSNGRV------------------------DFFRL-----MIQN-------------EIPDDQVKDT-----------------------TSEQPEKGLTDHEILSQSFIFIMGGYETTSTTLTFLLYNLAINPDCLEKLVEKIDKN--F-P--------------------------------------------------------------LDT----------PISYDA-LMKIDYLEMSINESM-RLLPTAP-RLERVCKKTVEM-NG--ITIPK------D-----------TMITIPTYV-LNQDPQLWDSPHEFRPE------RF--SPE--NK-SEFL---------QYAFMPFGLG-----------PRNCIGMRYAL-MIVKLLVVKLLQNFSVE----TCKE---TQIPLELNP-----------VFQPKV----PITL--K--L-----TPRKR- Danio_rerio_CYP3C3 ------LGIPG------------P-RPWPFFGTF----------LSY-----TKGFF--------NFDMECAK-----KYGKV--WGIYDGRLPILM-VTDLEMIKTIMVK--ECY--STFTNRREVNVDL-----AGPLADG---ISAVKDER-WKRIRGTLSPYFTSGRLKE---------IFPIAMTHADRFIKNMQK------------RDHEQP-----VKIKEVVAPYSLDVVTSSSFSVDIDSINNPDDPF------VTNIK-------NFLKFSLFSPLILFL--TLFPSIAN-LLGKM----GISVFSRSIMNFFYTALRKIKDEHKDSNGRV------------------------DFLRL-M---IQNQ--------------IPDDQAKDT-----------------------TSEQPVKGLTDHEILSQSFIFILGGYETTSTTLSFLLHNLATNPDCLEKLVEEIDKN--F-P--------------------------------------------------------------LDT----------PISYDA-LMKMDYLEMSINESM-RLLPTAP-RLERVCKKTVEL-NG--ITIPK------D-----------TLVAIPTYV-LNRDPQLWDSPQEFRPE------RF--SPE--NK-SEFL---------QYAFMPFGLG-----------PRNCIGMRFAL-MIVKLLVVKLLQNFSLE----TCKE---TQIPLELTP-----------VFQPKV----PITL--K--L-----TPRKR- Takifugu_rubripes_CYP3A40 ------VGIPG------------P-KPWPFIGTF----------LNY-----RRGIH--------HFDEECYK-----KYGKV--WGLYDGRQPLMC-IMDTGMIKTVLVK--ECY--SNFTNRRDLGVNG-PL--SDA-------VSVAEDEQ-WKRIRGILSPSFTSGRLKE---------MYTIMLQHSKNLLNFLNKK-----------VEADEV-----IDVKDVFGPYSMDVVTSTAFSVDIDSINNPSDPF------VANIK-------EMTQFSFLNPLVVLT--VLFPFLVP-IFKKM----NVSTFPAHVIDFFFNFLRQIKSDRNKDKKKSRV----------------------DFMQL-M---VNAQ-----------------MQEGNE------------------------EGSSQKGLTDNEILAQAMIFIFGGYETTSSSLGFLAYNLATNPKIQKKLQEEIDKT--FPG--------------------------------------------------------------KVR-----------PNYDD-LMQLEYLDMVVNESM-RVFPILS-RLERMTKTSVEI-NG--FTIPK------G-----------TVVAIPVYV-LQHDKAYWPEPEAFKPE------RF--SKE--NK-DNVD---------PYAYLPFGAG-----------PRNCIGNRFAL-VLMKLAIAEILQHYSFV----PCKE---TDIPMVLNT-------EG--LVAPKN----PIKL--K--L-----KPRAV- Danio_rerio_CYP3A65 ------LGIPG------------P-KAIPFFGTM----------LRY-----KDGFH--------VFDMDCFE-----KYGRI--WGIYDGRQPVLC-IMDQTIIKTVLIK--ECY--SLFTNRRNFRLNG-AL--YDA-------VSIAEDDD-WRRIRSVLSPSFTSGRLKE---------MFGIMKKHSHILVDSMGKT-----------AKRGES-----ADIKEFFGAYSMDVVTSTAFSVDIDSLNNPKDPF------VTNIK-------KMLKFDLLNPLFLLI--AFFPFMAP-VLEKM----DFALFPTSVTDFFYAALQKIKSDRDTKTVAKDNTKKRV-----------------DFLQL-M---VDSQ---------------TGVKHKSD------------------------GEHTEKGLSDHEILSQSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDET--F-P--------------------------------------------------------------NQA----------PVDYET-LMSMDYLDAALSESL-RLFPVAA-RLERVCKKTVEI-NG--LLIPK------D-----------LVVMVPTYA-LHRDPDYWSEPESFKPE------RF--TKG--NK-ESID---------PYMYMPFGLG-----------PRNCIGMRFAQ-VTMKLAIVEILQRFDVS----VCDE---TQVPLELGF-------NG--LLSPKD----PIKL--K--L-----QPRKL- Kryptolebias_marmoratus_CYP3A176 ------LGISG------------P-KPLPFFGTL----------LHY-----RKGFF--------NFDEECYK-----KYGKI--WGIYDGRQPVLC-IADPAMIKTVLIK--ECY--SLFTNRRNFRLNG-PL--YDA-------VSIAEDDQ-WRRIRSVLSPSFTSGRLKE---------MFAIMKRHSTNLVSSIKKKS----------ITLALWYSNISVCTYRFFGPYSMDIVTSTAFSVDIDSLHNPSDPF------VTNIK-------KMLKFDLLSPLFLAV--AFFPFVGP-IMEKL--EFSFFPKSVT--DFFYASLKKIKSNREKSRLQGRV----------------------DFLQL-M---IDSQ-----------------KNNNLS------------------------EGQEDKGLNDHEILSQSMIFLFAGYETTSSSLTFLAFNLATNPEVMKKLQEEIDAT--F-P--------------------------------------------------------------NKA----------PVEYAA-LMEMEYLDCVINESL-RLFPIAS-RLERVAKATVDI-NG--LVIPK------N-----------MVVLIPTWP-LHRDPELWPEPEKFKPE------RF--SKA--NK-DKID---------PYVYMPFGAG-----------PRNCIGMRFAL-VMMKLAVVEVLQRYSFS----VCKE---TEIPIELDI-------QG--LLMPKR----PIKL--K--L-----VPRSE- Kryptolebias_marmoratus_CYP3A177 ------LGISG------------P-KPLPFFGTL----------LHY-----RKGFF--------NFDEECYK-----KYGKI--WGIYDGRQPVLC-IADPAMIKTVLIK--ECY--SLFTNRRNFRLNG-PL--YDA-------VSIAEDDQ-WRRIRSVLSPSFTSGRLKE---------MFAIMKRHSTNLVSSIKKKS----------ITLALWYSNISVCTYRFFGPYSMDIVTSTAFSVDIDSLHNPSDPF------VTNIK-------KMLKFDLLSPLFLAV--AFFPFVGP-IMEKL----EFSFFPKSVTDFFYASLKKIKSNREKSRLQGRV----------------------DFLQL-M---IDSQ-----------------KNNNLS------------------------EGQEDKGLNDHEILSQSMIFLFAGYETTSSSLTFLAFNLATNPEVMKKLQEEIDAT--F-P--------------------------------------------------------------NKA----------PVEYAA-LMEMEYLDCVINESL-RLFPIAS-RLERVAKATVDI-NG--LVIPK------N-----------MVVLIPTWP-LHRDPELWPEPEKFKPE------RF--SKA--NK-DKID---------PYVYMPFGAG-----------PRNCIGMRFAL-VMMKLAVVEVLQRYSFS----VCKE---TEVRAQFSTFTQTYRSFG--ASPVQT----PVMG--D--D-----FERYI- Oryzias_latipes_CYP3A38 ------LGIPG------------P-KPVPFFGTM----------LAY-----RKGFP--------IFDEECHK-----KYGKT--WGIYDGRQPVLC-ITDPATIKAVLVK--ECY--SLFTNRRNFHLNG-PM--YDS-------VFNAEDDQ-WKRIRSVLSPSFTSGRLKE---------MFDIMKHHSANLVNSMKKK-----------ADKDEP-----LNLKDHFGPYSMDVVTSTAFSVDIDSLNNPSDPF------VTNIK-------KMLKFDFLNPLFLLV--AFFPFLGP-IMEKM--ELSFFPASAF--DFFYSALQKIKSDHKNNKQKSRI----------------------DFLQL-M---IDSQ-----------------KNNQNG--------------------------LQDKGLSDHEILSQAMIFIFAGYETTSSSLTFLAYNLATNPEVMKKLQKEIDAT--F-P--------------------------------------------------------------NKA----------PIQYAP-LLEMEYLDSVVNESL-RLYPIAA-RLERVAKATVEV-NG--LVIPK------D-----------MVVMVPTWP-IQRDPELWPEPEKFKPE------RF--SKE--TK-ETFD---------PYTYMPFGAG-----------PRNCIGMRFAL-VSMKLALVEILQQYSFS----VCKE---TEIPFELDI-------QG--LIAPKR----PIFL--K--L-----VPRSA- Oryzias_latipes_CYP3A40 ------LGIPG------------P-KPVPFFGTM----------LAY-----RKGFF--------NFDDECRK-----KYGKT--WGIYDGRQPVLC-ITDPATIKAVLVK--ECY--SLFTNRRNFRLNG-PL--YDA-------VSIAEDDQ-WKRIRSVLSPSFTSGRLKE---------MFDIMKHHSANLIQSMKKK-----------VDKDEP-----LEMKEYFGPYSMDVVTSTAFSVDIDSLNNPSDPF------VTNIK-------KMLKFDFLNPLFLAV--AFFPFLGP-ILEKF----EFSLFPSSVMDFFFAALRKIKANHENNKQKSRI----------------------DFLQL-M---IDSQ-----------------KNNQNG--------------------------LQDKGLSDHEILSQAMIFIFAGYETTSSSLTFLAYNLATNPEVMKKLQKEIDAT--F-P--------------------------------------------------------------NKA----------PVQYVP-LMEMEYLDCVVNESL-RLYPIAA-RLERVAKATVEV-NG--LVIPK------D-----------MVVMVPTWP-LHRDPELWPEPEKFKPE------RF--SKE--NK-DTFD---------PYTYMPFGAG-----------PRNCIGMRFAL-VMMKLAVVEILQTYDFS----VCKE---TEVPFEMDV-------QG--FLAPKR----PIQL--K--L-----TPRSA- Danio_rerio_CYP4V7 ------RPIPG------------MAGAYPIIGNA----------LQF-----KTNAG--------DFFNQIIEGTNENRHLPL--AKVWVGPVPFLI-LYHAENIEVVLSN--SRHLDKSYSYRFLHPWLG----------TG---LLTSTGEK-WRNRRKMLTPTFHFSILSD---------FLEVMNEQTDILIQKMQKLE----------DGE--P-----FNCFNFITLCALDIICETAMGKKIYAQSNADSEY------VQSVY----KMSDIITKRQRAPWLWPD------WIYN-KLKEG-----KEHAKRL--KILHSFTANVIRERAEFMSSEPD------SDSDQGERKRQ-----AFLDM-L---LKTT------------------------------------------------YENGQKLSHEDIQEEVDTFMFEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEV--F-G-------------------------------------------------------------SSER----------HVGVED-LKKLRYLECVIKESL-RIFPSVP-LFARSICEACHI-NG--FKVPK------G-----------VNAVIIPYA-LHRDPRYFPEPEEFQPE------RF--MPENSKG-----------RH-PYAYIPFSAG-----------PRNCIGQRFAM-MEEKVVLATILRHFDVE----ACQS--REELRPLGEL-----------ILRPEK----GIWI--K--L-----QRRSK- Danio_rerio_CYP4V8 ------KPIPG------------IGNTFPFIGNA----------LQF-----KSNGD------FFLQLVGYTT-----EFQNSPLLKIWIGPIPFLI-LFHAETVETVLNN--PVHIDKAYAYQFLHPWLG----------TG---LLTSTGDK-WRRRRKMLTPTFHFSILTE---------FLEVMNEQAEVLIEKLEKQ-----------AGK-GP-----FNCFSHITLCALDIICETAMGKRIYAQSNYDSEY------VRTVY----RMSDIITRRQRMPWY-------WPDFVY-NYVGE----GREHNRSL--KILHSFTESVINERAEYLSYVES-----DSESDQGMRKRR-----AFLDM-L---LKTK-----------------------------------------------D-EDGKMLTHKDIQEEVDTFMFEGHDTTAAAMNWAIHLLGSHPEVQRKAQQELFEV--F-G-------------------------------------------------------------ESER----------PVNTED-LKKLRYLECVIKESL-RLFPSVP-FFARTICDDTQI-NG--FKVPK------G-----------TNIVVITYA-LHRDPRFFPDPEEFRPE------RF--LPE------NCV------GRHPYAYIPFSAG-----------LRNCIGQRFAI-MEEKVILAYILRYFNIV----ACQK--REELRPLGEL-----------VLRPEQ----GIWI--T--L-----ERRKL- Kryptolebias_marmoratus_CYP4V2 ------KPIPG------------VDGTHLFIGDA----------LMF-----KPNAG--------EFFRQIVD--YTTSFRDVPLFKLWVGMIPFVV-LFHAETVEKVLSS--PVHLDKSFAYKFLHSWLG----------TG---LLTSTGQK-WRQRRKILTPTFHFSILTD---------FLHVMNEQAEVLVEKLEKK-----------AGQ-GP-----FNCFSDITLCALDIICETAMGKKIYAQSDSESEY------VKSVY----RMSDIISHRQRKPWFWPD--FIYYWFGQ----------GKEHDRTL--KILHSFTQRVIHEKSENMSSSDP-----DSDSDRDPKKRQ-----AFLDM-L---LKTT-----------------------------------------------D-EDGNRLSHQDIQEEVDTFMFEGHDTTAAAMNWTLHLLGSHPEVQWKVHQELQEV--F-G-------------------------------------------------------------TSGR----------PITTED-LKQLKYLDCVIKESL-RLFPSVP-YFARSLCADCHI-NG--FKIPK------G-----------ANAIVITYA-LHRDPRYFPEPEEFRPE------RF--FPQ------NSV------GRPPYAYIPFSAG-----------LRNCIGQRFAQ-MEEKVVLANILRNFSVE----ACQK--REELCPVGEL-----------ILRPKQ----GIRI--K--L-----ERRRF- Oryzias_latipes_CYP4V2 ------KPIPG------------LEKTYPIIGNS----------LYF-----KANAG--------EFFNQILEFCDTFRDEPL--FKIWLGPIPFVV-LFHSETVEKVLSN--PVHLDKSFAYTFLHPWLG----------TG---LLTSTGKK-WKQRRRILTPTFHFSILTD---------FLEVMNEQAELLVEKLDKL-----------AGKGQ------FNCFSHVTLCALDIICETAMGKKIYAQSNSESEY------VKSVY----KMSDIISRRQRAPWF-------WPDFLY-YFFGE----GKEHDKTL--KILHSFTKKVIYERSESLSHTES-----DGESDRGSRKRK-----AFLDM-L---LNTT-----------------------------------------------D-ENGNKLSHQDIQEEVDTFMFEGHDTTAASMNWALHLLGSHPEVQRKAQEELQEV--F-G-------------------------------------------------------------ASDR----------PATTED-LKKLKYLECVIKEAL-RLFPSVP-FFARRLGKDCHI-NG--FMVPK------G-----------ANAIIITYT-LHRDPRYFPEPEEFRPE------RF--LPENAAG-----------RP-PYAYVPFSAG-----------LRNCIGQRFAL-MEEKVVLSSILRKFNVE----ACQV--REDLRPVGEL-----------ILRPER----GIEI--K--L-----EKRGC- Takifugu_rubripes_CYP4V2 ------PELEG---------------TYPLIGNA----------LQF-----KPNAG--------DFFNQIVEYTRENYHRPL--FKIWVGPVPFVV-LFHPETVEPVLTN--AVHMEKSYSYSFLHPWLG----------TG---LLTSTGPK-WRRRRKMLTPTFHFSILAD---------FLEVMNEQAEILVEKLDQQ-----------AGK-GP-----FNCFSYVTLCALDIICETAMGKKIYAQSNSESEY------VKCVS----KMSDIISRRQRTPWF-------WPNFAY-YSIGD----GREHDSTL--KVLHSFTYKVITERAENVSSVES-----DSDSDHGRKKRQ-----AFLDM-L---LKTT-----------------------------------------------D-EDGNKMSHRDIQEEVDTFMFRGHDTTAASMNWVLHLMGSHPEAQSKVHQELQEV--F-G-------------------------------------------------------------ESNR----------PITTED-LKKLKYLESVIKEAL-RLFPSVP-FFARSLGEDCHI-NG--FKVPK------G-----------ANAVIITYA-LHRDPRYFPEPEEFRPE------RF--LPE--NS-VGRP---------PYAYLPFSAG-----------LRNCIGQRFAL-IEEKVVLASILRKFNVE----ACQK--REELRPVGEL-----------ILRPEK----GIWI--K--L-----EKRKP- Danio_rerio_CYP4T8 ------ERFPG------------P-PAHWLFGHV----------KEF-----RQDGH------DLEKIVKWME-----LYQFA--FPLWFGPSLAVLNIHHPSYAKTILTT--TEPK-DDYAYKFFIPWLG----------DG---LLVSTGQK-WFRHRRLLTPGFHYDVLKP---------YVKLISDSTKVMLDKWEVH-----------SRSEES-----FELFKHVSLMTLDSIMKCAFSCNSNC---QTDSG------TNPYI----QAVFDLCHLVNLRFRVFP--YHSKAIFH-LSPHG-----YRFRKAA--SIAHNHTAEVIRKRKEVLKMEEE------------QGIVKNRRYLDFLDI-----LLSA-----------------------------------------------RDEHQQGLSDEDIRAEVDTFMFEGHDTTASGISWIFYNLACNPEHQEKCRQEIQQA--LDG---------------------------------------------------------------KD----------TLEWED-LNKIPYTTMCIKESL-RLHPPVP-GISRKLTKPLTFFDG--RTVPE------G-----------CTIGVSIYG-IHMNSTVWENPYKFDPL------RF--LPE--NA--ANR------S--PHAFVPFSAG---------------------------------------------------------PRF-----------VTRSV-------------------------- Takifugu_rubripes_CYP4T10 ------ESFPG------------P-PGHWLFGNI----------LEF-----KQDGN------DLDKLVKFGQ-----KYPYC--FPLWFGPFVCFLNIHHPEYVKTILAS-------TEPKDDLAYSFIQNWI----G--NG---LLVSQGQK-WFRHRRLLTPGFHYDVLKP---------YVKLMAHSTKTMLDKWESY-----------AKTNKP-----LEVFEYVSLMTLDTILNCAFSYDSN----CQTES------PHGFR------------------------------------------YRKACMVA-----HSHTEEVIKKRREALKKEKE------------LERIQAKRNLDFLDI-L---LFAK-----------------------------------------------D-ENQQGLLDEDIRAEVDTFMFEGHDTTASGISFLLYNLACHPKHQKLCRKEIMQV--LHG---------------------------------------------------------------KD----------TMDWED-LNKIPYTTMCIKESL-RMHPPVP-GISRKTTKPITFFDG--RTLPA------E-----------SRIGTSVFG-IHRNASIWENPNVFDPL------RF--LPE--NI--SKR------P--PHAFVPFSAG-----------PRNCIGQNFAM-NEMKVVIAMTLLKYELL----EEPT---LKPKIIPRL-----------VLRSLN----GIHI--K--I-----KNANQ- Oryzias_latipes_CYP4T12 ------EAFPG------------P-PGNWLFGHV----------LQL-----KQDGT------DLERGLKWGE-----QYPYA--FPMWFGPSVCFLNIHHPDYAKTILTT--TEPK-DDLAYRFIESWIG----------NG---LLVSKGQK-WFRHRRLLTPGFHYDVLKH---------YVNLMSESAQVMLDKWESY-----------ANTSET-----FELFEHVSLMTLDSILKCAFSHNSNC---QREGE------TNKYI----KAVYELSDLISFRMRTFP--YHSDLIFY-LSPHG----FRHRRAC---KVAHSHTQEVIRKRKEALKEETE--------SSRKRNL-------DFLDI-L---LFAK-----------------------------------------------D-ENQQGLSDEDIRAEVDTFMFEGHDTTASGISFILYCLASHPEHQKICRNEVMEA--LDG---------------------------------------------------------------KD----------TIEWED-LNKIPYTTMCIKESL-RLYPPVP-GISRKLTKPITFFDG--RTLPA------G-----------FKVGTSVFG-IHRNATVWENPEVFDPL------RF--LPE--NV--SKR------S--PHAFVPFSAG-----------ARNCIGQNFAM-NEMKVVIAMTLKKYQLI----EEPS---LKPRIIPRL-----------VLRSLN----GIHI--K--I-----KPVEA- Kryptolebias_marmoratus_CYP4T17 ------EAFPG------------P-PGNFLLGHV----------LEF-----KQDGT------DLFRTVKWAR-----TYPYG--FPMWFGPFLCLLSVHHPDYVKTILTS--SEPK-DEFVYSFLMPWIG----------DG---LLVSKGQK-WFRHRRLLTPGFHYDVLKP---------YVQLMSQSAKTMLDKWESY-----------AKTNEN-----FELFEHVSLMTLDTILQCAFSCKSNC---QTEGG------TNAYI----KAVYELSNIVNFRLRTFP--YHSDLIFH-LSPHG-----FKFRKAC--KVAHSHTEEVIRKRKEALKEETE------------LGRIQAKRYLDFLDI-L---LVAR-----------------------------------------------D-ENQQGLSNEDIRAEVDTFMFEGHDTTASGISFLLYCLACNPEHQKICREEILQV--LDG---------------------------------------------------------------KD----------TMEWED-LNKIPYTTMCIKEAL-RLYPPVP-GMSRKLTKPVTFFDG--RTLPA------G-----------FRVGVSVFS-VHRNPAVWENPDVFDPL------RF--LPE--NV--TKR------S--PHAFVPFSAG-----------PRNCIGQNFAM-NELKVVAAMTLKRYQLI----EDPD---FKPKMVPRL-----------ILRSLN----GVHI--K--I-----KPVEP- Kryptolebias_marmoratus_CYP4T18 ------EAFPG------------P-PGNFLLGHV------------L-----EFKQD--GT--DLFRTVKWAR-----TYPYG--FPMWFGPFLCLLSVHHPDYVKTILTS-------SGICFALICLICP-TL--FLG--DG---LLVSKGQK-WFRHRRLLTPGFHYDVLKP---------YVQLMSQSAKTMLDKWESY-----------AKTNEN-----FELFEHVSLMTLDTILQCAFSCKSNC---QTEGG------TNAYI----KAVYELSNIVNFRLRTFP--YHSDLIFH-LSPHG-----FKFRKAC--KVAHSHTEEVIRKRKEALKEETE------------LGRIQAKRYLDFLDI-L---LVAR-----------------------------------------------D-ENQQGLSNEDIRAEVDTFMFEGHDTTASGISFLLYCLACNPEHQKICREEILQV--LDG---------------------------------------------------------------KD----------TMEWED-LNKIPYTTMCIKEAL-RLYPPVP-GMSRKLTKPVTFFDG--RTLPA------GQ*HLSVFTETKCVCSICFWI-LQREDKMITIQLVFDPL------RF--LPE--NV-TKRS---------PHAFVPFSAG-----------PRNCIGQNFAM-NELKVVAAMTLKRYQLI----EDPD---FKPKMVPRL-----------ILRSLN----GVHI--K--I-----KPVEP- Danio_rerio_CYP4F3 ------NQPPL--------------RNW-IMGHM----------GLM-----GHNEE------GLQRVDDLVC-----KYGHS--CSWFLGPFYNMVRLFHPDYIRSLLTA--SAS--ITLKDRIFYGFMKPWL--GNC-------LLLQSGQE-WSRHRRLLTPAFHFDILKK---------YVHIFNQSTNIMHDEWRRL-----------LAKGEH----SVDMFEQISSLTLDSLLKCTFSCDT-----HSQEK------PRQYI----SAILDLSRLLVQRQHYLP--YHWDWLYW-RSAQG-----RRFQQAC--AVVHQFTADIVQERRTQLDQQSDPESHPENTGRYRKRKNT-----DLIDLLL---LAKD-------------------------------------------------DKGEGLTNEEIKAHADMFMFAGHDTTASALSWIFYNLAMNQDYQERCRAEVRDL--L----------------------------------------------------------------ADR-------DTHTIGWED-LSQLTFTTMCIKESL-RLHSPVL-ALTRYYSQNMKTPGD--CVIPH------G-----------CLCLISIYG-VHRNPQVWPDPLVFDPT------RF---DP--HNSDSRS---------PHAFIPFSAG-----------PRNCIGQNFAM-AEMKVVVALTLARFKIL----PGPK----PVRRLYQL-----------VLRAEG----GMIL--H--F-----QELNE- Kryptolebias_marmoratus_CYP4F128 ------DKPET--------------RSW-LLGHL----------GQM-----QSTEE------GLQRVDDLVQ-----TYKHS--CCWFLGPFYHLVRIFHPDYVKPLLMASGNITVKDELIYGHLRPWLG----------KS---LLISNGEE-WSHRRRLLTPAFHFDILKN---------YVTTFNSSTNTMHNKWSRL-----------VAEGTT----NLEMFNHVTLMTLDSLLKCAFSYSSN----CQEST-------NEYV----AAIVELSDLVIDRRFRIL--HHWDWIYW-KTQQG-----KRFKRAL--SVVHRFTREVVQKRRALISQQRE--TETQTTLTTTPQKKK-----DFVDV-I---LLSK-----------------------------------------------D-DDEQGLSDEEIQAEANTFMFAGHDTTASAICWTLYNLARHSHHQEKCRQEVMEL--MEG--------------------------------------------------------------RERH---------AIEWED-LSNLPFTTMCIRESL-RLHSPVQ-AVTRRYTQDMTLPGG--LSVPE------G-----------VICLVSLYG-THHNPAVWANPHEFDPL------RFDPANTRSHS--------------SHAFIPFSSG-----------PRNCIGQKFAM-AELRVVVALTLLRFRLTLGVDPKSGSGSKGVRRLPQL-----------VLRAEG----GLWL--Q--L-----EPLNP- Danio_rerio_CYP39A1 ------NAPPC------------IRGWIPWFGAA----------FEF-----GKAPL--------HFIQQARA-----KYGPV--FTVVAAGKRMTF-VTLNEDFRVFFTS--KD---VDFEQAVQEPVHN---------------TASISKDNFFESHPTCSAIIKGRLTPGN------TAMLSPHLCEEFNDHLESLGS------------EGS------------GQLNELIKSVMYPSVMSNLLGR---CNSPS--------SAL----SRQEFLEKFTTYDEGFEYGSQLPEMFLKEWSNSK--------------HWLLSLLRKMVIKSEETLYSESD----------------R--------KT-L---LQHL---------------------------------------------------AASISEQYLPNYGLLLLWASLANAIPVTFWAVAFILSNPTAYKIVMDQINSV--L-G-------------------------------------------------------------RQDKQKT-------KVTLDD-LQQMPYVKWCIMEAI-RLR--APGAITRKVVRPLKL-QN--YVIPP------G-----------DMLMLSPYW-AHRNPKYFPDPEDFKPE------RWETADL--EK--NVL---------LEGFVAFGGG-----------KNQCPGRWYAI-MELHMFVALILYKFEFAQLDPMPKP---SPLHLVGTQ-------------QPDG----PCTV--R--Y-----KHR--- Kryptolebias_marmoratus_CYP8B1 ------GEPPL------------DKGLIPWLGHV----------LEF-----RRDTF--------KFLERMKK-----KHGDV--FTVQLAGNYITF-LQDPLSFGAFVKESRKKLDFNTFAEQMVYRVFG----------------YVPIEED-YHILHSSSNKHLKGEGLDV---------MTEAMMSNLQNLMLHSVSS-----------DQK--------TWKEDGLFMYSYNIVFRAGYLALFG----NVPHK------SEGGEEQAKEKDRSQSETLFYEFRKYD--QLFPNLAL-GVLSP------KQQWEV--DRLQTFFWDAVSVQKMKANDNIS----------------------RWVWD-M---HQAK-----------------------------------------------E-EL--GVKESNINKYLFVLLWASQGNTGPSSFWLLLFLLKHPEAMKAIREEVDEV--L-K--------------------------------------------------------------ETGQEVQPGCPLINLTHEM-LTKTPILDSAVEETL-RLTAAPLLLRAVLQNMTLKMADGREYFIRE------G-----------DRMGIFPYEDVHLDPEIHPDPLSFKYD------RF--LNP--DG-SKKTDFYKAGKKVKYYNMPWGAG-----------VSMCPGRFFAT-NELKQFVFLMLIYFEFE---LMNPD--EKIPEIDFRR-------WGFGSMQPVR----DVQF--R--Y-----RLRY-- Kryptolebias_marmoratus_CYP8B14 ------GEPPL-----------DK-GLIPWLGHV----------LEF-----RRDTF--------KFLERMKK-----KHGDV--FTVQLAGNYITF-LQDPLSFGAFVKESRKKLDFNTFAEQMVYRVFG----------------YVPIEED-YHILHSSSNKHLKGEGLDV---------MTEAMMSNLQNLMLHSVSS-----------DQK--------TWKEDGLFMYSYNIVFRAGYLALFGNVPHKSEGG------EEQAK----EKDRSQSETLFYEFRKYD--QLFPNLAL-GVLSP--------KQQWEVDRLQTFFWDAVSVQKMKANDNIS----------------------RWVWD-----MHQA-------------------------------------------------KEELGVKESNINKYLFVLLWASQGNTGPSSFWLLLFLLKHPEAMKAVREEVDKV--L-K--------------------------------------------------------------ETGQEVQPGCPLINLTHEM-LTKTPILDSAVEETL-RLTAAPLLLRAVLQNMTLKMADGREYFIRE------G-----------DRMGIFPYGDVHLDPEIHPDPLSFKYD------RF--LNP--DG-SKKTDFYKAGKKVKFHNMPWGAG-----------VSMCPGRFFPT-NELKQFVFLMLIYFEFE---LMNPD--EKIPEIDFRR-------CGLGSMQPVR----DVQF--R--Y-----RLRY-- Danio_rerio_CYP8B1 ------GEPPL------------EKGPIPWLGHV----------LEF-----RKDTA--------KFLNRMKA-----KHGDI--FTVQLGGFYFTF-ITDPLSFGAVVKEARAKLDFTKFAEQLVQRVFG----------------YHSIQSE-HKVLQASSTKHLMGDGLVV--------MTQAMMYNLQNLMLHSVGSG-----------NGK--------VWQESGLFAYSYNIVFRAGYLSLFG----NESPKGTGKESVEKAK----EIDRQESNDLFWEFRKYD--QLFPNLAY-GVLGP----SEKMEA----ERLKRLFWSTLSVQKMRARDNIS----------------------GWVSD-----QQQV-------------------------------------------------RAEHGMQEFMQDRYMFLLLWASQGNTGPSAFWLLLYLMKHPEAMSAVRKEVEEI--L-K--------------------------------------------------------------EAGQEVKPGGPLIDLSRDM-LLKTPILDSAVEETL-RLTAAPILTRAVMQDMTIIMANGQEYKIRE------G-----------DRVAVFPYV-VHVDPEVHPDPLTFKYD------RF--LNA--DG-SRKTDFYKGGKKLKYYSMPWGAG-----------TTMCPGRFFAT-NELKQFVFLMLSYFDFE----LTNP-NEQIPGIDIRR-------WGFGSMQSDR----DIQF--R--Y-----RPRI-- Danio_rerio_CYP8B2 ------GEPPL------------EKGLIPWLGCV----------LEF-----RKDTV--------KFLQRMKA-----KHGDI--FTVQLGGFYFTF-ITDPQSFGAVVKESRAKLDFTNFADQLVERVFG----------YG---AVEIKHKF-FKNLQTTSTKHLMGDGLVV--------MTQAMMYNLQNLMLHSVGSG-----------NGK--------VWQESGLFAYSYNIVFRAGYLSLFG----NESPKGTGKESVEKAK----EIDLQHSNDLFWEFRKYD--QLFPNLAY-GVLGP----RGKMEA----ERLKRLFWNMLSVQKMKARDNVS----------------------GWVSD-----QQQV-------------------------------------------------RAEHGMQEFMQDRFMFLLLWASQGNTGPSAFWLLLYLMKHPEAMSAVRKEVEEI--L-K--------------------------------------------------------------EAGQEVKPGGPLIDLSRDM-LLKTPILDSAVEETL-RLTTAPLLTRGVMEDMTIIMANGQEYKIRE------G-----------DRVSVFPYL-VHIDPEVHPDPLTFKYD------RF--LNA--DG-SRKTDFYKDGKKLKYYSMPWGAG-----------TTMCPGRFFAT-NELKQFVFLMLSYFDLE----LKNP-NEEIPSIETRR-------WGFGSMHPDR----DIQF--R--Y-----RPRI-- Danio_rerio_CYP8B3 ------GEPPL------------EKGLIPWLGCV----------LEF-----RKDTV--------KFLQKMKA-----KHGDI--FTVQLGGFYFTF-ITDPLSFGAVVKESRAKLDFTKFSDQLVERVFG----------------YHPMENE-HKFLQTASTKHLMGDGLVV--------MTQAMMYNLQNLMLHSVGSG-----------NGK--------VWQESGLFAYCYNIVFRAGYLSLFG----NESPKGTGKESVEKAK----EIDLQHSNDLFCEFRKYD--QLFPNLAY-GVLGP----RGKMEA----ERLKRLFWSTLSVQKMRVKDNIS----------------------GWISD-----QQQV-------------------------------------------------RAELDMQEFMQDRFMFLLLWASQGNTGPSAFWLLLYLMKHPEAMSAVRKEVEEI--L-K--------------------------------------------------------------EAGQEVKPGGPLIDLSRDM-LLKTPILDSAVEETL-RLTTVPLLTRGVVQDMTIIMANGQEYKIRE------G-----------DRVSVFPYL-VHIDPEVHPDPLTFKYD------RF--LNA--DG-SRKTDFYKDGKKLKYYSMPWGAG-----------TTMCPGRFFAT-NELKQFVFLMLSYFDFE----LTNP-NEQIPDIDIRR-------WGFGSMHPDR----DIQF--R--Y-----RPRI-- Danio_rerio_CYP8A1 ------NEPPL------------DKGMIPWLGHA----------LEF-----GKDAA--------KFLTRMKE-----KHGDI--FTVRAAGLYITV-LLDSNCYDAVLSD-VASLDQTSYAQVLMKRIFN---------------MILPSHNP--ESEKKRAEMHFQGASLTQ---------LSNSMQNNLRLLMTPSE-------------MGLKTS-----EWKKDGLFNLCYSLLFKTGYLTVFG----AENNN------SAALT----QIYEEFRRFD----------KLLPKLARTTVNKE----EKQIASAA-----REKLWKWLTPSGLDRKPREQ----------------------SWLGS-Y---VKQL--------------------------------------------------QDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQ------G---------------------------------------------------------------GK----------HLRLEERQKNTPVFDSVLWETL-RLTAAALITRDVTQDKKICLSNGQEYHLRR------G-----------DRLCVFPFISPQMDPQIHQQPEMFQFD------RF--LNA--DR-TEKKDFFKNGARVKYPSVPWGTE-----------DNLCPGRHFAV-HAIKELVFTILTRFDVE----LCDKNATVPLVDPSRY--------GFGILQPAG----DLEI--R--Y-----RIRF-- Kryptolebias_marmoratus_CYP8A1 ------NEPPL------------DQGLIPWLGHA----------LEF-----AKDVP--------KFITRMKL-----KHGDI--FTVRVAGHYVTL-LLDPHSYDAVIGD-PTSLDFSRYAQVLMRRIFS---------------LELPLEQP--AKAKTMMKTHFLGKSLSA---------LNSTMSRHLEALLKTEMPQ-----------NQR--------SWKEEGLFNLSYGLIFKAGYLTLFA----GERNN------NGPGA-----------SEVYQEYKAFD--SLLCKLAR-GMLKA------EEKKTA--QSAQRRLWELLAPAGLTGDSGSS----------------------SWLHA-Y---RRLL-----------------------------------------------Q-ED--GVDEESQRKAVLMQLWASQGNVGPAAFWLLGYLLTNPDALLAVREEFGKLEKS-G---------------------------------------------------------------------------SPLLDR-AVNTPVFDSVLEEIL-RLTAAPFITREVVQEKILCMADGQEYLLRK------G-----------DRVCLFPFISPQMDPEVYREPQRFKHD------RF--LNE--DGSAKRD-FYKGGKQLKYPTMPWGAG-----------ANGCVGKPFAI-STIRKFVYLLLTNYDLE----LCDPNAQMPEINASRY--------GFGMLQPEG----DLPI--R--Y-----RPRDT- Kryptolebias_marmoratus_CYP8A2 ------NEPPL------------DKGHIPWLGHA----------LEF-----GKDAA--------KFLARMKE-----KHGDI--FTVCVAGHYVTV-LLDPSSFDGVLGD-TVSFDFSRIRGQLVKRIFS---------------LQLPNSDP--ALERAWMETHFQGVSLRK---------LSSSMSSHLYNLLVTNRNS-----------CSS--S-----MWTEDELFGFCYSLLFRAGYLTLFE----KEDNA-------AAVY----REFRKFDELLTKLARSTL--------------------KREEGKIA--RASQEQLWELLSPRCLNEDSD------------------------SWQQS-----YRRF-------------------------------------------------LREQGMDADVQNKALLLQLWTTQCNAGPAAFWILGFLLTHPEAMEAVKLEIRGLSTLQN-----------------------------------------------------------TSLQRP----------ALNQLE-AQHTPVFDSVLKETL-RLTAAVMINREVMQEKVLRMADGREYLLRR------G-----------DRVCLFPFLSPQMDPEIHQEPQMFKYD------RF--LTP--SR-TLKDDFYKDGRRLKYYIMPWGAG-----------RNSCVGREFAA-AAIRQFVFLLLTHLDLE----LCHPDAKLPPVNPKRY--------GFGMLQPDG----DLQV--R--Y-----RLKTT- 'Kryptolebias marmoratus CYP8A2-like' ------NEPPL-----------DK-GHIPWLGHA----------LEF-----GKDAA--------KFLARMKE-----KHGDI--FTVCVAGHYVTV-LLDPSSFDGVLGD-TVSFDFSRIRGQLVKRIFS---------------LQLPNSDP--ALERAWMETHFQGVSLRK---------LSSSMSSHLYNLLVTNRNS-----------CSS--S-----MWTEDELFGFCYSLLFRAGYLTLFE----KEDNA-------AAVY----REFRKFDELLTKLARSTL--------------------KREEGKIA--RASQEQLWELLSPRCLNEDSD------------------------SWQQS-----YRRF-------------------------------------------------LREQGMDADVQNKALLLQLWTTQCNAGPAAFWILGFLLTHPEAMEAVKLEIRGLSTLQN-----------------------------------------------------------TSLQRP----------ALNQLE-AQHTPVFDSVLKETL-RLTAAVMINREVMQEKVLRMADGREYLLRR------G-----------DRVCLFPFLSPQMDPEIHQEPQMFKYD------RF--LTP--SR-TLKDDFYKDGRRLKYYIMPWGAG-----------RNSCVGRDEFTIISSRPFVFLLLTHLDLE----LCHPDAKLPPVNPKRY--------GFGMLQPDG----DLQV--R--Y-----RLKTT- Danio_rerio_CYP7B1 ------GEPPL------------IKGWIPFLGKA----------LEF-----RKNSQ--------EFLTRLQK-----EHGDD--FTVLIAGRYITF-IMNPLQYPSVIKH-GKQLDFHTFSDSAASRTFD-YPPIRSGHFPG------------LSDQIQRSYTLLQGPALDP---------LTFSMMGNLQKVLRQLFLS-----------GDEADD-----HWQQAELYKFCKSAMFQSTFKTLYG--------H------SPHLD----------LDQLREDFEKFD--DMFPLLMA-RIPIG-------LLGKT--KEIREKLIHFFYPQRMMEWTAPC----------------------EFVQTRT---ALFQ--------------------------------------------------DYDTLQDRDKAAHHFAMLWASVGNTIPAAFWCLYHLISCPEALAAVREEITNV--L-G---------------------------------------------------------------EKNMQLIFKEDIAITRQQ-LEQMVYLESSVNESL-RLYSVSMNIRVVQEDFCLRLDGQRSINMRK------D-----------DIIALYPQS-THLDPEIYKEPKRFQFD------RF--VKD--GK--EKTDFYKSGQKVRYYRMPFGSG-----------ATQCPGRFFAM-NELKQFVCVTLLMCEMQ----LLDG--QQEASMDNSR-------AGLGILPPAN----PIPF--K--Y-----KTRKT- Kryptolebias_marmoratus_CYP7C1 ------GEPPL------------IQGWIPFLGKA----------LEF-----RKDAH--------KFLEEQRR-----TYGDV--FTVLIGGKYMTF-IMDPLLYPSIIKH-GRQLDFDKFTMRVAPRVFG----------YTKTELFPGL----WDQVKR-CYQLLQGDSLTP---------LTESMMANLMLVFRQDHLD-----------QGH--------SWRTGNMYEFCALVMFEATFLTIYG----KPETG------IRHHQ----------MDQLWNNFVEFD--NMFPYLFA-EVPIW-------LLGRT--KAIRQKLISHFLPQRMSRWSNTC----------------------QFIRR-----RSEL------------------------------------------------FDQYDKLKDVDKAAHHSTILWASVGNTVPATFWAIYHLAAHPEALQVVRQEILDV--L-R---------------------------------------------------------------ANGMEFSPRRDVMLSRDQ-LDKLVFLESSISESL-RLSSASMNIRVAQEDFSLRLDAERSVAVRN------G-----------DIIALYPQS-VHLDPEIYEDPQTFRFD------RF--VQDGREK-TDFQ---KDGQKLKHFLMPFGSG-----------SSKCPGRYFAI-NEIKQFVCLLLLYFDLQ----LEDGQNRPLLDSSRIG-------LG--ILHPSS----DVRF--R--Y-----RLRAE- Danio_rerio_CYP7D1 -----------------------------MLCNL-------------------------------QTVLERCL-------------------------PHEHDWLEEGL---------QSFTNR----------------------IMFEAG-------------------------------------------------------------------------------------------FLTLFG----KEDIG------FLQDH----GMSGNRISMPKATQDFLVFDHAFPLLAA-GVPIG------LCTKAW--RAREALAEELLHDELHRRKCIS-----------------------DLIQR-R---MDIF--------------------------------------------------DRMLLDETGKARTHVCMLWASQANTLPAAFWSLYYTLKSVDAFTAARTEVNRV--LLG-----------------------------------------------------------QSLNNK------DQTVYLSKDQ-LDSMTVLESIIEEAL-RLSSASMMIRVASDDFTLTLESDQTAAIRK------G-----------DYIALYPQL-LHLDPEIYPNPTEFKYN------RF--LDENDQPKTNFF---KSGRRLRNFLMPFGSG-----------ASECPGRFFAV-YEIKLFLALTLWHYDLQ----LRDP---DVPVVQDSA------RAGLGIMPPSQ----DVLL--R--F-----RKKQR- Danio_rerio_CYP7A1 ------AEPPL------------ENGWIPFLGCA----------LQF-----GANPL--------EFLRSRQK-----KHGHI--FTCKIAGQYVHF-LCDPFSYHAVIRQ-------GRHLDWKKFHFDA------SAKAFGHESMDPSQGYT-TENLHQTFLKTLQGDALSS---------LIETMMENLQGTMLQSGML-----------KATTSE------WQSDGIYAFCYKVMFEAGYLTLFG--KELDGDQ------SIARQ----QAQKALVLNALDNFKEFD--KIFPALIA-GLPIH-------VFKSA--YSAREKLAKTMLHENLSRRANVS----------------------DLISLRM---LLND--------------------------------------------------TLSTFNELSKARTHVAILWASQANTLPATFWTLFHMIRCPAAMKAASEEVRRT--F-E--------------------------------------------------------------SSNQKVDPTNSRLVLTREQ-LDNMPVLDSIIKEAM-RLSSASLNVRMAKSDFLLQLDNKESYHIRK------D-----------DVIAMYPPM-IHFDPEIYDDPLEFKYD------RY--IDE--NG-QEKTTFYRNGRKLRYYYMPFGSG-----------VTKCPGRFFAV-HEIKQFLSLLLSYFEME----LLDSDVKEPPLDQSRA--------GLGVLQPTY----DVDF--R--Y-----RLKSL- Kryptolebias_marmoratus_CYP7A1 ------GEPAV------------ENGFIPYLGCA----------LQF-----GANPL--------QFLRSRQK-----KYGHI--FTCKIAGRYIHF-LCDPFSYHSVIRQ-------GRHLDWKKFHFST----SVKA--FGHDSFDPRHGYT-TENLHQTFMKTLQGEALTS---------LIETMMGHLQDVMLKSDTL------------GSNKD-----QWQVDGIFAFCYKVMFESGYLTLFG--KELGDDK------CRAHQ----EAQKSLVLNTLENFKEFD--KIFPALVA-GLPIH-------VFKSA--YSARENLAKTMYAENLSKRHHMS----------------------DLISMRM---ILND--------------------------------------------------SLSTFNDVSKARTHVALLWASQANTLPATFWSLFYMIRCPDAIKAAYTEVQTV--L-R--------------------------------------------------------------DLGLTPDPDGPILNLTRNQ-LDNMPVLDSIIKEAM-RLSSASMNVRVAKEDFLLHLDNQEAYHIRK------D-----------DVIALYPPM-LHFDPKIYEDPYEYKFN------RF--LDE--KG-EEKTTFYRNGQRLRYFYMPFGSG-----------VTKCPGRFFAV-CEIKQFLTLMLSYFDME----LLDPAIKVPPLDQSRA--------GLGILQPTY----DVDF--R--Y-----KLKPK- ; END; BEGIN ASSUMPTIONS; TYPESET * UNTITLED = unord: 1 - 804; END; BEGIN NOTES; TAXABITS NAME = newlyAddedTaxon on = 1 - 233; END; BEGIN CODONS; CODESET * UNTITLED = universal: 1 - 804; END; BEGIN MESQUITECHARMODELS; ProbModelSet * UNTITLED = 'Mk1 (est.)': 1 - 804; END; BEGIN TREES; Title Imported_trees; ID 016041bdcfb71; LINK Taxa = Taxa; TRANSLATE [0] 1 Danio_rerio_CYP19A1A, [1] 2 Takifugu_rubripes_CYP19A1, [2] 3 Kryptolebias_marmoratus_CYP19A1, [3] 4 Oryzias_latipes_CYP19A1, [4] 5 Danio_rerio_CYP19A1B, [5] 6 Takifugu_rubripes_CYP19A2, [6] 7 Kryptolebias_marmoratus_CYP19A2, [7] 8 Oryzias_latipes_CYP19A2, [8] 9 Danio_rerio_CYP20A1, [9] 10 Takifugu_rubripes_CYP20A1, [10] 11 Kryptolebias_marmoratus_CYP20A1, [11] 12 Oryzias_latipes_CYP20A1, [12] 13 Danio_rerio_CYP51, [13] 14 Kryptolebias_marmoratus_CYP51A1, [14] 15 Danio_rerio_CYP11C1_ORF, [15] 16 Takifugu_rubripes_CYP11C1, [16] 17 Kryptolebias_marmoratus_CYP11C1v1, [17] 18 Oryzias_latipes_CYP11C1, [18] 19 Danio_rerio_CYP11A1, [19] 20 Kryptolebias_marmoratus_CYP11A1, [20] 21 Oryzias_latipes_CYP11A2, [21] 22 Danio_rerio_CYP24A1, [22] 23 Kryptolebias_marmoratus_CYP24A1, [23] 24 Danio_rerio_CYP27C1, [24] 25 Takifugu_rubripes_CYP27C1, [25] 26 Kryptolebias_marmoratus_CYP27C1, [26] 27 Oryzias_latipes_CYP27C1, [27] 28 Danio_rerio_CYP27B1, [28] 29 Kryptolebias_marmoratus_CYP27B1, [29] 30 Danio_rerio_CYP27A3, [30] 31 Kryptolebias_marmoratus_CYP27A3, [31] 32 Danio_rerio_CYP27A7, [32] 33 Danio_rerio_CYP27A1.4, [33] 34 Danio_rerio_CYP27A5, [34] 35 Danio_rerio_CYP27A6, [35] 36 Kryptolebias_marmoratus_CYP27A1, [36] 37 Oryzias_latipes_CYP27A1, [37] 38 Danio_rerio_CYP26A1, [38] 39 Takifugu_rubripes_CYP26A1, [39] 40 Kryptolebias_marmoratus_CYP26A1, [40] 41 Oryzias_latipes_CYP26A1, [41] 42 Danio_rerio_CYP26B1, [42] 43 Kryptolebias_marmoratus_CYP26B1, [43] 44 Oryzias_latipes_CYP26B1, [44] 45 Danio_rerio_CYP26C1, [45] 46 Takifugu_rubripes_CYP26C1, [46] 47 Kryptolebias_marmoratus_CYP26C1, [47] 48 Oryzias_latipes_CYP26C1, [48] 49 Kryptolebias_marmoratus_CYP1C2, [49] 50 Kryptolebias_marmoratus_CYP1C1, [50] 51 Oryzias_latipes_CYP1C1, [51] 52 Danio_rerio_CYP1C1, [52] 53 Danio_rerio_CYP1C2, [53] 54 Danio_rerio_CYP1B1, [54] 55 Takifugu_rubripes_CYP1B1, [55] 56 Kryptolebias_marmoratus_CYP1B1, [56] 57 Oryzias_latipes_CYP1B1, [57] 58 Kryptolebias_marmoratus_CYP1A, [58] 59 Danio_rerio_CYP1A, [59] 60 Takifugu_rubripes_CYP1A1, [60] 61 Danio_rerio_CYP1D1, [61] 62 Kryptolebias_marmoratus_CYP1D1, [62] 63 Oryzias_latipes_CYP1D1, [63] 64 Danio_rerio_CYP2U1, [64] 65 Takifugu_rubripes_CYP2U1, [65] 66 Oryzias_latipes_CYP2U1, [66] 67 Kryptolebias_marmoratus_CYP2U1, [67] 68 Danio_rerio_CYP2X10.1v1, [68] 69 Danio_rerio_CYP2X10.2v2, [69] 70 Danio_rerio_CYP2X12c2, [70] 71 Danio_rerio_CYP2X12c1, [71] 72 Danio_rerio_CYP2X9, [72] 73 Danio_rerio_CYP2X8, [73] 74 Danio_rerio_CYP2X7, [74] 75 Danio_rerio_CYP2X6, [75] 76 'Takifugu rubripes CYP2X-like', [76] 77 Oryzias_latipes_CYP2X20, [77] 78 Kryptolebias_marmoratus_CYP2X27, [78] 79 Kryptolebias_marmoratus_CYP2X25, [79] 80 Kryptolebias_marmoratus_CYP2X26, [80] 81 Oryzias_latipes_CYP2X14, [81] 82 Kryptolebias_marmoratus_CYP2X24, [82] 83 Danio_rerio_CYP2AA12, [83] 84 Danio_rerio_CYP2AA11, [84] 85 Danio_rerio_CYP2AA6, [85] 86 Danio_rerio_CYP2AA8, [86] 87 Danio_rerio_CYP2AA9, [87] 88 Danio_rerio_CYP2AA3, [88] 89 Danio_rerio_CYP2AA4, [89] 90 Danio_rerio_CYP2AA7, [90] 91 Danio_rerio_CYP2AA1, [91] 92 Danio_rerio_CYP2AA2, [92] 93 Danio_rerio_CYP2R1, [93] 94 Kryptolebias_marmoratus_CYP2R1, [94] 95 'Takifugu rubripes CYP2K-like2', [95] 96 Oryzias_latipes_CYP2K28, [96] 97 Kryptolebias_marmoratus_CYP2K42, [97] 98 Kryptolebias_marmoratus_CYP2K39, [98] 99 Kryptolebias_marmoratus_CYP2K52, [99] 100 Kryptolebias_marmoratus_CYP2K43, [100] 101 Kryptolebias_marmoratus_CYP2K40, [101] 102 Kryptolebias_marmoratus_CYP2K41, [102] 103 Kryptolebias_marmoratus_CYP2K46, [103] 104 Kryptolebias_marmoratus_CYP2K44, [104] 105 Kryptolebias_marmoratus_CYP2K45, [105] 106 Kryptolebias_marmoratus_CYP2K51, [106] 107 Danio_rerio_CYP2K6, [107] 108 Danio_rerio_CYP2K22, [108] 109 Danio_rerio_CYP2K31, [109] 110 Oryzias_latipes_CYP2K30, [110] 111 Kryptolebias_marmoratus_CYP2K47, [111] 112 Kryptolebias_marmoratus_CYP2K50, [112] 113 Kryptolebias_marmoratus_CYP2K48, [113] 114 Takifugu_rubripes_CYP2K1, [114] 115 Kryptolebias_marmoratus_CYP2K49, [115] 116 Oryzias_latipes_CYP2K29, [116] 117 'Takifugu rubripes CYP2K-like1', [117] 118 Oryzias_latipes_CYP2K27, [118] 119 Kryptolebias_marmoratus_CYP2K38, [119] 120 Danio_rerio_CYP2K16, [120] 121 Danio_rerio_CYP2K8, [121] 122 Danio_rerio_CYP2K17, [122] 123 Danio_rerio_CYP2K18, [123] 124 Danio_rerio_CYP2K20, [124] 125 Danio_rerio_CYP2K19, [125] 126 Danio_rerio_CYP2K21, [126] 127 Danio_rerio_CYP2Y3, [127] 128 Danio_rerio_CYP2Y4, [128] 129 'Takifugu rubripes CYP2Y-like', [129] 130 Kryptolebias_marmoratus_CYP2Y9, [130] 131 Oryzias_latipes_CYP2Y6a, [131] 132 Oryzias_latipes_CYP2Y6b, [132] 133 Danio_rerio_CYP2AE1, [133] 134 Danio_rerio_CYP2AD6, [134] 135 Danio_rerio_CYP2AD2, [135] 136 Danio_rerio_CYP2AD3, [136] 137 'Takifugu rubripes CYP2AD-like', [137] 138 Oryzias_latipes_CYP2AD7, [138] 139 Kryptolebias_marmoratus_CYP2AD12, [139] 140 'Kryptolebias marmoratus CYP2AD12-iso', [140] 141 Danio_rerio_CYP2V1, [141] 142 'Takifugu rubripes CYP2Z-like', [142] 143 'Oryzias latipes CYP2N-like2', [143] 144 Kryptolebias_marmoratus_CYP2Z6, [144] 145 'Kryptolebias marmoratus CYP2Z6-like', [145] 146 Danio_rerio_CYP2P6, [146] 147 Danio_rerio_CYP2P7, [147] 148 Danio_rerio_CYP2P10, [148] 149 Danio_rerio_CYP2P8, [149] 150 Danio_rerio_CYP2P9, [150] 151 'Takifugu rubripes CYP2P-like', [151] 152 Kryptolebias_marmoratus_CYP2P19, [152] 153 Kryptolebias_marmoratus_CYP2P20, [153] 154 Kryptolebias_marmoratus_CYP2P16, [154] 155 Kryptolebias_marmoratus_CYP2P17, [155] 156 Kryptolebias_marmoratus_CYP2P18, [156] 157 Oryzias_latipes_CYP2P15, [157] 158 Oryzias_latipes_CYP2P12, [158] 159 Oryzias_latipes_CYP2P13, [159] 160 Danio_rerio_CYP2N13, [160] 161 'Takifugu rubripes CYP2N-like', [161] 162 Kryptolebias_marmoratus_CYP2N22, [162] 163 'Oryzias latipes CYP2N-like1', [163] 164 Oryzias_latipes_CYP2Z5, [164] 165 Kryptolebias_marmoratus_CYP2N23, [165] 166 Oryzias_latipes_CYP2N18, [166] 167 Oryzias_latipes_CYP2N20, [167] 168 Danio_rerio_CYP21A1, [168] 169 Kryptolebias_marmoratus_CYP21A1, [169] 170 Danio_rerio_CYP17A1, [170] 171 Kryptolebias_marmoratus_CYP17A1, [171] 172 Takifugu_rubripes_CYP17A1, [172] 173 Danio_rerio_CYP17A2, [173] 174 Takifugu_rubripes_CYP17A2, [174] 175 Kryptolebias_marmoratus_CYP17A2, [175] 176 Oryzias_latipes_CYP17A2, [176] 177 Kryptolebias_marmoratus_CYP46A1, [177] 178 Kryptolebias_marmoratus_CYP46A2, [178] 179 Kryptolebias_marmoratus_CYP46A4, [179] 180 Kryptolebias_marmoratus_CYP46A5, [180] 181 Danio_rerio_CYP46A1.3, [181] 182 Danio_rerio_CYP46A1.1, [182] 183 Danio_rerio_CYP46A1.2, [183] 184 Danio_rerio_CYP46A1.4, [184] 185 Danio_rerio_CYP5A1, [185] 186 Kryptolebias_marmoratus_CYP5A6, [186] 187 Kryptolebias_marmoratus_CYP5A2, [187] 188 Kryptolebias_marmoratus_CYP5A3, [188] 189 Kryptolebias_marmoratus_CYP5A4, [189] 190 Kryptolebias_marmoratus_CYP5A1, [190] 191 Takifugu_rubripes_CYP3A30, [191] 192 Takifugu_rubripes_CYP3A27, [192] 193 Kryptolebias_marmoratus_CYP3B10, [193] 194 'Oryzias latipes CYP3A56-like', [194] 195 'Oryzias latipes CYP3A40-like', [195] 196 Oryzias_latipes_CYP3B5, [196] 197 Danio_rerio_CYP3C1, [197] 198 Danio_rerio_CYP3C4, [198] 199 Danio_rerio_CYP3C2, [199] 200 Danio_rerio_CYP3C3, [200] 201 Takifugu_rubripes_CYP3A40, [201] 202 Danio_rerio_CYP3A65, [202] 203 Kryptolebias_marmoratus_CYP3A176, [203] 204 Kryptolebias_marmoratus_CYP3A177, [204] 205 Oryzias_latipes_CYP3A38, [205] 206 Oryzias_latipes_CYP3A40, [206] 207 Danio_rerio_CYP4V7, [207] 208 Danio_rerio_CYP4V8, [208] 209 Kryptolebias_marmoratus_CYP4V2, [209] 210 Oryzias_latipes_CYP4V2, [210] 211 Takifugu_rubripes_CYP4V2, [211] 212 Danio_rerio_CYP4T8, [212] 213 Takifugu_rubripes_CYP4T10, [213] 214 Oryzias_latipes_CYP4T12, [214] 215 Kryptolebias_marmoratus_CYP4T17, [215] 216 Kryptolebias_marmoratus_CYP4T18, [216] 217 Danio_rerio_CYP4F3, [217] 218 Kryptolebias_marmoratus_CYP4F128, [218] 219 Danio_rerio_CYP39A1, [219] 220 Kryptolebias_marmoratus_CYP8B1, [220] 221 Kryptolebias_marmoratus_CYP8B14, [221] 222 Danio_rerio_CYP8B1, [222] 223 Danio_rerio_CYP8B2, [223] 224 Danio_rerio_CYP8B3, [224] 225 Danio_rerio_CYP8A1, [225] 226 Kryptolebias_marmoratus_CYP8A1, [226] 227 Kryptolebias_marmoratus_CYP8A2, [227] 228 'Kryptolebias marmoratus CYP8A2-like', [228] 229 Danio_rerio_CYP7B1, [229] 230 Kryptolebias_marmoratus_CYP7C1, [230] 231 Danio_rerio_CYP7D1, [231] 232 Danio_rerio_CYP7A1, [232] 233 Kryptolebias_marmoratus_CYP7A1; TREE Imported_tree_1 = (((((((((((((((((((((101:0.08848548,102:0.09812146):0.01044436[%bootstrapFrequency = 0.3 ],99:0.15557264):0.02454544[%bootstrapFrequency = 0.505 ],100:0.10893638):0.01637918[%bootstrapFrequency = 0.895 ],98:0.18007234):0.01200282[%bootstrapFrequency = 0.34 ],97:0.18649949):0.05109245[%bootstrapFrequency = 0.915 ],(103:0.19608266,(104:0.16354912,(105:0.08875379,106:0.1033924):0.03560312[%bootstrapFrequency = 0.935 ]):0.0206263[%bootstrapFrequency = 0.75 ]):0.0389697[%bootstrapFrequency = 0.935 ]):0.05697905[%bootstrapFrequency = 0.925 ],96:0.18845584):0.06354282[%bootstrapFrequency = 1 ],95:0.33593316):0.10960383[%bootstrapFrequency = 0.945 ],(117:0.22058139,(118:0.19666098,119:0.16518674):0.02942559[%bootstrapFrequency = 0.8 ]):0.10422912[%bootstrapFrequency = 0.985 ]):0.02350427[%bootstrapFrequency = 0.385 ],(((108:0.11788061,109:0.06269593):0.0753705[%bootstrapFrequency = 0.98 ],107:0.10442626):0.29300046[%bootstrapFrequency = 1 ],((120:0.21481917,121:0.22425312):0.04793921[%bootstrapFrequency = 0.545 ],(122:0.08557789,(124:0.07052874,(123:0.09619475,(125:0.02993033,126:0.02600262):0.01062645[%bootstrapFrequency = 0.925 ]):0.02044932[%bootstrapFrequency = 0.2 ]):0.08683187[%bootstrapFrequency = 0.99 ]):0.17215574[%bootstrapFrequency = 1 ]):0.0092681[%bootstrapFrequency = 0.9 ]):0.09101798[%bootstrapFrequency = 0.68 ]):0.03029446[%bootstrapFrequency = 0.56 ],(((111:0.09576858,112:0.17363022):0.15455977[%bootstrapFrequency = 1 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],231:1.13716384):0.25413196[%bootstrapFrequency = 0.955 ],((((227:0.0,228:0.02210842):0.44320382[%bootstrapFrequency = 1 ],226:0.43838233):0.08260388[%bootstrapFrequency = 0.735 ],225:0.46317115):0.52349383[%bootstrapFrequency = 1 ],((220:0.03162636,221:0.04093771):0.25972366[%bootstrapFrequency = 1 ],(222:0.02980442,(223:0.05406551,224:0.03182839):0.03585001[%bootstrapFrequency = 0.72 ]):0.24066056[%bootstrapFrequency = 1 ]):0.40763723[%bootstrapFrequency = 1 ]):0.35513155[%bootstrapFrequency = 1 ]):0.90549511[%bootstrapFrequency = 1 ]):0.71192148[%bootstrapFrequency = 1 ]):0.13960625[%bootstrapFrequency = 0.645 ]); END; Begin MESQUITE; MESQUITESCRIPTVERSION 2; TITLE AUTO; tell ProjectCoordinator; timeSaved 1513869751034; getEmployee #mesquite.minimal.ManageTaxa.ManageTaxa; tell It; setID 0 6466930194225552184; tell It; attachments ; endTell; endTell; getEmployee #mesquite.charMatrices.ManageCharacters.ManageCharacters; tell It; setID 0 8426448767308581779; mqVersion 331; checksumv 0 3 1973493292 null getNumChars 804 numChars 804 getNumTaxa 233 numTaxa 233 short false bits 2097151 states 2097151 sumSquaresStatesOnly 1.119558763921313E15 sumSquares 1.119558763921313E15 longCompressibleToShort false usingShortMatrix false NumFiles 1 NumMatrices 1; mqVersion; endTell; getWindow; tell It; suppress; setResourcesState false false 100; setPopoutState 300; setExplanationSize 0; setAnnotationSize 0; setFontIncAnnot 0; setFontIncExp 0; setSize 1515 1123; setLocation 8 8; setFont SanSerif; setFontSize 10; getToolPalette; tell It; endTell; desuppress; endTell; getEmployee #mesquite.charMatrices.BasicDataWindowCoord.BasicDataWindowCoord; tell It; showDataWindow #8426448767308581779 #mesquite.charMatrices.BasicDataWindowMaker.BasicDataWindowMaker; tell It; getWindow; tell It; setExplanationSize 30; setAnnotationSize 20; setFontIncAnnot 0; setFontIncExp 0; setSize 1415 1051; setLocation 8 8; setFont SanSerif; setFontSize 10; getToolPalette; tell It; endTell; setActive; setTool mesquite.charMatrices.BasicDataWindowMaker.BasicDataWindow.arrow; colorCells #mesquite.charMatrices.ColorByState.ColorByState; tell It; setStateLimit 9; toggleUniformMaximum on; endTell; colorRowNames #mesquite.charMatrices.TaxonGroupColor.TaxonGroupColor; colorColumnNames #mesquite.charMatrices.CharGroupColor.CharGroupColor; colorText #mesquite.charMatrices.NoColor.NoColor; setBackground White; toggleShowNames on; toggleShowTaxonNames on; toggleTight off; toggleThinRows off; toggleShowChanges off; toggleSeparateLines off; toggleShowStates on; toggleAutoWCharNames off; toggleAutoTaxonNames off; toggleShowDefaultCharNames off; toggleConstrainCW on; toggleBirdsEye off; toggleShowPaleGrid off; toggleShowPaleCellColors off; toggleShowPaleExcluded off; togglePaleInapplicable on; toggleShowBoldCellText off; toggleAllowAutosize off; toggleColorsPanel off; toggleLinkedScrolling on; toggleScrollLinkedTables off; endTell; showWindow; getWindow; tell It; forceAutosize; endTell; getEmployee #mesquite.charMatrices.AlterData.AlterData; tell It; toggleBySubmenus off; endTell; getEmployee #mesquite.charMatrices.ColorCells.ColorCells; tell It; setColor Red; removeColor off; endTell; getEmployee #mesquite.categ.StateNamesStrip.StateNamesStrip; tell It; showStrip off; endTell; getEmployee #mesquite.charMatrices.AnnotPanel.AnnotPanel; tell It; togglePanel off; endTell; getEmployee #mesquite.charMatrices.CharReferenceStrip.CharReferenceStrip; tell It; showStrip off; endTell; getEmployee #mesquite.charMatrices.QuickKeySelector.QuickKeySelector; tell It; autotabOff; endTell; getEmployee #mesquite.charMatrices.SelSummaryStrip.SelSummaryStrip; tell It; showStrip off; endTell; getEmployee #mesquite.align.AlignToDropped.AlignToDropped; tell It; gapCosts 16 6 1 1; subCosts 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5; endTell; getEmployee #mesquite.molec.SequenceInfoEditor.SequenceInfoEditor; tell It; panelOpen false; endTell; endTell; endTell; endTell; end;