#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 19, 2025; 19:50 GMT TreeBASE (cc) 1994-2008 Study reference: Kohl K.P., Jones C.D., & Sekelsky J. 2012. Evolution of a MCM complex in flies promoting meiotic crossovers by blocking BLM helicase. Science, . TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S13435] [ The following blocks are input data for analysis step 10164 ] BEGIN TAXA; TITLE TaxaForAnalysisStep10164; DIMENSIONS NTAX=25; TAXLABELS Aedes_aegypti_MCM5 Aedes_aegypti_MCM8 Anopheles_gambiae_MCM5 Anopheles_gambiae_MCM8 Arabidopsis_thaliana_MCM5 Arabidopsis_thaliana_MCM8 Culex_quinquefasciatus_MCM5 Culex_quinquefasciatus_MCM8 Danio_rerio_MCM5 Danio_rerio_MCM8 Dictyostelium_discoideum_MCM5 Dictyostelium_discoideum_MCM8 Drosophila_melanogaster_MCM5 Drosophila_melanogaster_REC Drosophila_pseudoobscura_MCM5 Drosophila_pseudoobscura_REC Drosophila_virilis_MCM5 Drosophila_virilis_REC Glossina_morsitans_MCM5 Glossina_morsitans_REC Homo_sapiens_MCM5 Homo_sapiens_MCM8 Methanopyrus_kandleri_MCM Strongylocentrotus_purpuratus_MCM5 Strongylocentrotus_purpuratus_MCM8 ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M14518] TITLE 'MCM5 + MCM8 metazoans MCM domain alignment'; LINK TAXA = TaxaForAnalysisStep10164; DIMENSIONS NCHAR=720; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .] Aedes_aegypti_MCM5 ANPTNIRDLKSECVSRLVKVAGIIIAASGIKAKATKISIQCRSCSNVIPNLPVNPGLEGYQLPRKC-TTEQTGRPKCPMDPY-FIMPDKC---KCVDFQVLKLQE--LPDFIP-QGEIPRHMQLFCD-RTLCERVVPGNRVLIHGIFSIRKIGKPSKQDGREKA---------IIGVRAPYMRVVGITV------------------DTEGMGSISRFSNITTEEESTFRKLAAN--PNIYDSLSESLAPSIFGSQDIKKAIVCLLFGGSRKRM-----PDGLTRRGDINILLLGDPGTAKSQLLKFVEQVAPIAVYTSG--KGSSAAGLTASVIRDPATRNFVMEGGAMVLADG-GVVCIDEFDKMKEDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTK-GEENIDFMPTILSRFDMIFIVKDVHDQARDITLAKHVMNVHMN----------------ANKTT-LETQEGE---------------------------------------------------------------------VPLALFKKYINYCRTHCGP----RLNEEAAEKLKSRYVLMRSGAGEHERMAD--------------------------------------------KRLSIPITVRQLEAVIRISESLAKMQLQPFATEAHVTEALRLFQVSTL------------------ Aedes_aegypti_MCM8 GPEVHLRHMKINSFGKLFAVRGTIIRAGNSQVLNSWMAFRCSLCHG-QQAIRQTDGM--LTLPTSC-------REGCKARSN-FIPLRSSVFTRTEAFQTVRLQESMLGARSG-HGQVPRSIEVELT-HELVDAVCPGDDVTITGILKGRP----QEENSSKART--------TASMYKMYMQAVAVRS------------------NKNSLASWHRAAEFSDLDMEAIRMIRSE--PCPFRLLVQSLCPMIYGHEMIKAGLLLGLFGGASITK---------GRRSEIHVLIVGDPGIGKSQMLQSCAEVSPRGIFVCG--NSTSNAGLTVAVRTEKCTGG-ALEAGALVLADQ-GACCIDEFDKMSGNHQILL-EAMEQQVVSVAKAGVICSLPARTCILAAANPSGGHYDKSKTVSENLKMKPALLSRFDLVFIQLDRPNAHLDNLLAAHVQRLHGM--------QNGQQPQGAAFQALLIGMGTTTIHGS------------------------------------------QAETPLHERLKIRANEK--MDLLPVELIQKYIAYARKNIHP----KLTEAAALEIRNFYAEMRRAQQGM---------------------------------------------------DSIPVTTRQLEALVRLTQARARMDLESEATLQHAQDVIAILRYSMI------------------ Anopheles_gambiae_MCM5 ANPTNIRDLKSDCVSKLVKVAGIIIAASGIKAKATRISIQCRTCNNVIPNLPVNPGLEGYQLPRKC-NTEQAGRPKCPLDPY-FIMPDKC---RCVDFQVLKLQE--LPDFIP-QGEIPRHMQLFCD-RSLCERVVPGNRVLIHGIFSIRKIARQGKRDGRDKA---------IIGVRAPYMRVVGITV------------------DTEGMGAISRFNNITSEEESTFRKLAAN--PNIYDTLADSLAPSIFGSQDIKKAITSMLFGGSRKRM-----PDGLTRRGDINILLLGDPGTAKSQLLKFVEKVAPIAVYTSG--KGSSAAGLTASVIRDPATRNFIMEGGAMVLADG-GVVCIDEFDKMKEDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTK-GDENIDFMPTILSRFDMIFIVKDEHDQQRDITLAKHVMSVHMN----------------ASKAT-AEPKEGE---------------------------------------------------------------------IPLAMLKKYIHYCRTHCGP----RLNEAAAEKLKSQYVRLRAGVGEHEKAID--------------------------------------------KRLSIPITVRQLEAIIRISESLAKMQLQPFATEAHVSEALRLFAVSTM------------------ Anopheles_gambiae_MCM8 GPEVSISSIKVSSMGKLVSVRGTIIRAGATQIMNTWCAFRCAQCGS-EQAVQQKDGI--YTTPTSC-------HSGCKARSH-FVLLQQSAFTRMEAYQTLRLQETTQGSRTV-AGSAAKNIEIELT-HELVDSVCPGDDVTVTGILKARS-----QDGSDGAGK---------ASMFKAYLQAVYVRS------------------NKNVLANWNRLAEFTELDMEAIRLIKAE--PSPFRLLVQSLCPTIYGHEIVKAGLLLGLFGGMANTA---------RTRAEIHVLVVGDPGIGKSQILQSCANVSPRGIFVCG--TNSSNVGLTVTVRTEKGVGA-SLEAGALVLADQ-GVCCIDEFDKMSG-HSGLL-EVMEQRSVSVAKAGVICTVPARTTVLAAANPAGGHYNKAKTVSENLKLHPALLSRFDLVFILLDRSNERTDNLLTAHIQKVHGLA------KAGSSHLQPQPSHPFFDASGHCSYEE-------------------------------------------EGEPPLEERLRLAPGEQ--MDLLPPEIVQKYIGYARKNVQP----KLTAKAAEELREFFVELRRAHNHM---------------------------------------------------DMIPVTTRQLEGLIRLTQARAKIDLSPEATVAHVRDVLAILRQSML------------------ Arabidopsis_thaliana_MCM5 EDPVSMRLLGAQYISKLVKISGISIAASRVKAKATYVFLVCKNCKK-TREVPCRPGLGGAIVPRSCDNIPQPGEEPCPLDPW-MVVPDRS---QYVDQQTLKLQE--NPEDVP-TGELPRNMLLSVD-RHLVQTIVPGTRLTVMGIYSIFQ---ASSSSNSHKG---------AVAIRQPYIRVVGLED----------------TNEASSRGPA----NFTPDEEEEFKKFADS--QDVYKNICTKIAPSIFGHEDVKRAAACLLFGGSRKSL-----PDGVKLRGDINVLLLGDPSTAKSQFLKFVEKTAPIAVYTSG--KGSSAAGLTASVIRDSSTREFYLEGGAMVLADG-GVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPPSGRYDDLKTAQDNIDLQTTILSRFDLIFIVKDIRKYSQDKEIASHIIRVHAS----------------ANKFSDENTDSKE-----------------------------------------------------------------------DNWLKRYIQYCRARCHP----RLSKDAAENLQRKYVTIRMDMKRRAHETG--------------------------------------------EAAPIPITVRQLEAIVRLSESLAKMRLSHEATPDDVDKAFKLFDTSTM------------------ Arabidopsis_thaliana_MCM8 ESSISLKNLRAAYIGKLVTVHGTVVKVSTVKPLVTQMAFDCGKCKT-GITREFTDGK--FSPPLKC------DSHGCKSKT--FTPIRSS--AQTIDFQKIRVQELQKPEDHE-EGRVPRTVECELM-EDLVDICIPGDVVTVTGIIGVINN--YMDIGGGKSKTK-------NQGFYYLFIEAVSVKNTKRQSA----FENSEDSSSSAQTADVGDLYSFSQRDLEFIVKFKEEYGSDTFRRILHSVCPSIYGHEIVKAGITLSLFGGVRKHS---MDRNKVPVRGDIHVIIVGDPGLGKSQLLQAAAAISPRGIYVCG--NATTRAGLTVAVVKDSMTNDYAFEAGAMVLADG-GLCCIDEFDKMTTEHQALL-EAMEQQCVSVAKAGLVASLSARTSVIAAANPVGGHYNRAKTVNENLKMSAALLSRFDLVFILLDKPDELLDKQVSEHIMSHH------------RMLGMQTCMQKGILYFQDCG-----------------------------------------------------------------WTLRKMTTFLRFLANCLGNIFPMHGILMSKDAGEIIQKFYLKLRDHNTSA---------------------------------------------------DSTPITARQLESLVRLAQARARVDLREEITVQDAMDVVEIMKESLY------------------ Culex_quinquefasciatus_MCM5 ANATNIRDLKSECVSRLVKVAGIIISASGIKAKATRISIQCRTCSNVIPNLPVNPGLEGYQLPRKC-NTEQAGRPKCPLDPY-FIMPDKC---RCVDFQVLKLQE--LPDFIP-QGEIPRHMQLFCD-RSLCERVVPGNRVLIHGIFSIRKIGNPGKQDGREKA---------IIGVRAPYMRVVGITV------------------DTEGVGSISRFNNITIEEESMFRKMAAN--PNIYDTLTESLAPSIFGSQDIKRAIVCMLFGGSRKRM-----PDGLTRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSG--KGSSAAGLTASVMRDPATRNFVMEGGAMVLADG-GVVCIDEFDKMKEDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTK-GEDNIDFMPTILSRFDMIFIVKDVHDQARDMTLAKHVMNVHMN----------------ANKAT-VETQEGE---------------------------------------------------------------------VSLATFKKYINYCRTHCGP----RLNEGAAEKLKARYVTMRSGAGEAERQSD--------------------------------------------KRLSIPITVRQLEAVIRMSESLAKMQLQPFATEQHVTEALRLFQVSTL------------------ Culex_quinquefasciatus_MCM8 GPEVHLRYLNINNWQKLIAVRGTITRAEGSIIISTWLTFRCSLCHG-LQVIRQPTGA--YAVPTSC-------RKGCKARSN-FVADRWSPYTRNEPFQKVRLQESNMGARSE-QGQVPRSIEVEFG-HELVDAVCPGDDVTVTGIVMCRS----QEENSSRANN--------SATMYKTYLKAVAVRS------------------NKNAKPGWHRGEEFTELDLEAVKAIRAE--PSVFRLMVQSLCPMIHGHEMIKAGLLLGIFGGSAIAG---------GRRSEIHVLVVGDPGIGKSQILQACARVSPRGIFVCG--NSTTNAGLTVNVRSEKGTGA-TLEAGALVLADQ-GVCCIDEFDKMSANNQVLL-EAMEQQVISVTKAGVMCTMPARTSILAAANPAGGSYDKSKTVSENIRMKPALLSRFDLVFTQLDQNDIQLDLMYTKHV-DLRGN---------LGTQD-GAALQALLTNGHHSSQPQSS------------------------------------------QAPPLHQSLKLRPGEK--MDTLPEELMQKYIAFTRKNINP----RLSREAAQELRSFYGEIRRAQQGM---------------------------------------------------HCFPVTTRQIEALIRLTQARARMDLVAEATVGHALDVIAILRFSMV------------------ Danio_rerio_MCM5 AHPASIRSLKSEQVSRLVKIPGIIISSTAVRAKATRVCLQCRGCRAVISNIPLPPGLQGYALPRKC-NTEQAGRVKCPVDPY-FIIPDRC---VCVDFQTQRLQE--APDAVP-HGEMPRHMQLYCD-RYLCDRVVPGNRVTVMGIYSIKKVA-QTKAKGRDKGT--------GVGIRSAYLRVVGIDV------------------DTEGA-GRGATGSVSPQEEEELRSLAAS--PSVYDSLARSLAPSIYGSDDLKKAIACLLFGGSRKRL-----PDGLTRRGDINLLMLGDPGTAKSQLLKFVERCSPIGVYTSG--KGSSAAGLTASVLRDPTTRGFVMEGGAMVLADG-GVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDDTK-GEDNIDFMPTILSRFDMIFIIKDHHDQQRDMTLARHVMNVHLS----------------AQTQTEGV--EGE---------------------------------------------------------------------IPLATLKKYIAYSRVKCGP----RLSAAAAEKLKNRYVLMRSGAKEHERETD--------------------------------------------RRVSIPITVRQLEAVVRIAESLAKMKLQPIAGEEEVDEALRLFQVSTL------------------ Danio_rerio_MCM8 EPLTPLKSLRANLYGKFVVIRGTVVRVSNIKPLCMKLAFVCNSCGD-TQSVTLPDGK--YTMPTKC------LQSECRGRS--FTPNRSSPFTLTVDWQTIKVQELMSGDQRE-SGRIPRTIECELT-QDLVDSCVPGDMVTITGVIKVSN-----EEGSTRNKK--------DKCMFLLYIQANSVSN-----------SKGQKSKAVSESEGQGPSVEFSIKDLYAIQEIQAQ--EDLFKLIVNSLCPVIYGHLLVKAGLALALFGGCQKYV---DDKNRIPIRGDPHMLIVGDPGLGKSQMLQAVCNVAPRGVYVCG--NTTTTSGLTVSLSRDSGSGDYALEAGALVLGDQ-GICCIDEFDKMGSQHQALL-EAMEQQSISLAKAGIVCTLPARTSIIAAANPVGGHYNKGKTVSENLKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVMAMRAG----------KSGAVSGAAATRFNTHESSISILEVS-----------------------------------------SEKPLADTLKLVPGEA--FDPIPHQLLRKYVGYARHYVHP----TLSAEAAQVLQDFYLELRKQNQTA---------------------------------------------------DSTPITTRQLESLIRLTEARARVELREKATQSDAEDVVEIMKHSLT------------------ Dictyostelium_discoideum_MCM5 ANPEPIRYLRAGLISKLVKVQGIVISASRTQPKPSTMVVKCKNCQH-TQTLHIRPGIVSSVLPQQCERGSNDAGKPCPNNPY-VVLSDQS---TFVNQQILKLQE--SPETIP-TGEMPRHIILSLD-KSLADKITPGTRIKVLGVLGIFE----GGGKRREIA---------GGTIRTNYLRVLGITS------------------DNAGRDSM----HFTPSEEQSFKVFSRR--QDLRNIIASSIAPSIYGHEDIKRAISCQLFGGSSKKL-----PDKMRLRGDINLLLLGDPGTAKSQLLKFVEKVAPISVYTSG--KGSSAAGLTASVIREPSTGEYYLEGGAMVVADG-GVVCIDEFDKMNVDDRVAIHEAMEQQTISIAKAGITTILNSRTSVLAAANPVYGRYNDA--ADDNINFQSTILSRFDLIFIVKDPKNEKRDFIISKHVINIHEK-----SSRSGGSGSVGNNTYDLSNTVVDDSH-------------------------------------------------IG-------------ENEVTIQYLKKYIAYARSRISP----RLSEDAVTTLKNHYVSVRAKSKEQEMINNGSYGGGGSKNSVETERKK--------------------------RKNAIPITVRQLEAIIRISESLAKMSLSPIATNEHAKEAIRLFDISTF------------------ Dictyostelium_discoideum_MCM8 EPLLQLKKLKANLIDKFVSLKGTVIRVGNVKPLVTQMQFICNKCSTRTPTQYFTEGK--VTFPSNC------LNHGCRGKI--FEPDRST--AVTIDWQKIRIQE--DADQKE-SSGIPKAFECEIT-DEMVETIVPGDIVTISGVVKVLR----AEETGFQNQ---------NKPVFLIYIDVNSIDS----------------PKRTSGNGGKIETTSFSLKDMYGIKEIAEH--PNIFKLISNSICPTIYGHELVKAGLTLALFGGSPNRSSNGSDKNKLSIRSDPHVLIVGDPGLGKSQMLTSIYHLSPRGVYVCG--GYSSTTGLTVTLLREKGSGDFAIEAGALVLADQ-GCCCIDEFDKMTDEHPALL-EAMEQQSVSIAKAGIVCNLPARTSVVAAANPVGGHYNRAKTVSENIKMSAPLLSRFDLIFILMDKPNTEKDHIISHNILNLHSNGS-----GVKKRKPQQSSSSSSATTNSSQYTHEEDHD----------------------------------------KSLPLKQKLLITHGQE--INLIPTVILRKYISYAKKYVSP----RLSEEAIKVIQKFYLELRSKSTGS---------------------------------------------------DSMPVTTRQLESLIRLAEARAKLELRETVTEQDAIDIVEIMRDSLL------------------ Drosophila_melanogaster_MCM5 ANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYALPRKC-NTEQAGRPKCPLDPF-FIMPDKC---KCVDFQTLKLQE--LPDFVP-QGEIPRHLQLFCD-RSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKA---------VVGVRAPYMRVVGITV------------------DSEGAGAISRYSNITSDEEEHFRRMAAS--GDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRL-----PDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSG--KGSSAAGLTASVMKDPQTRNFVMEGGAMVLADG-GVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTK-GEENIDFMPTILSRFDMIFIVKDIHDESRDITLAKHIINVHLS----------------SNKSAPSEPAEGE---------------------------------------------------------------------ISLSTFKKYIHYCRTHCGP----RLSEAAGEKLKSRYVLMRSGAGQQEKASD--------------------------------------------KRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQVSTL------------------ Drosophila_melanogaster_REC VPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQM-EIAMRQRGTF--QPRPYQC------KRSECVARDE-FVPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMPAEMDVELR-HDLVDAVRVGQEVVVTGILKLQE----LGDDTTTGD---------TSNQMQPYLKAVSIRD------------------------ASSIKREFSERDLEAIVMINAE--PNSFKLLVQSIAPEVYGHELPKAACLLSLLGGKGAET------------EAINVLLVGDPGIGKTKILQSCAQIAERGAHVSG--KRGAQSAQQLGVTFAGRNKR-VLQAGSLMMASGGGHCTLDDVDKLASKQAVLL-QCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSE-RDMSLTAHVRALHAG---------ARKRARIAARYALKPKMSDSMCEV---SLNVPAAGKDDDTIKTEDDNDSIMQ----------------QDYDLDKRLEVLPEEG-DLDLLPPILIKKFLSYARQELNP----VLNEDASNAVLRYFLELKGSCNLD----------------------------EDVS---------------------SQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESIT------------------ Drosophila_pseudoobscura_MCM5 ANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATKISIMCLSCSTVIPNLRVNPGLEGYAMPDKC-TTEQAGRPKCPLDPF-FVMPDKC---KCVDFQTLKLQE--LPDFVP-QGEIPRHLQLFCD-RSLCERVVPGNRVLIQGIYSIRKVGKPSRQDGREKA---------VVGVRAPYMRVVGITV------------------DAEGAGAISRYNNITTDEEDNFRRMAAS--GDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRL-----PDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSG--KGSSAAGLTASVMKDPQTRNFVMEGGAMVLADG-GVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTK-GEENIDFMPTILSRFDMIFIVKDVHDETRDITLAKHIINVHLS----------------SNKSAPTEPAEGE---------------------------------------------------------------------ISLSTFKKYIHYCRTHCGP----RLSEAAGEKLKSRYVLMRSGAGQQEKNAD--------------------------------------------KRLSIPITVRQLEAVIRISESLAKIRLLPFVADDHVNEALRLFQVSTL------------------ Drosophila_pseudoobscura_REC TPVELTTGISADRVDTLFSVRGIVSSVGEPTYSIAWQSFRCSRCQT-EQAMRQRGSF--QPRPYHC------KQAQCVAKDS-FVPLRSSPYTRISAKQIVRLEESSLSLIADYDSILPGEIDVELR-HDLVDCVHVGQEIVVNGVLKLRD----LGEDVTSATGSVAG----DSNELKAYLKAASVQD------------------------ARHKKREFSERDLEAIAMINAE--PNSFKLLVQSLAPEVHGHELPKAACLLSLLGGGA---------------GGVNVLLVGDPGIGKSKILQNCAQITERGSHISG--KRGAQSAQRLGPTFTGRNKR-VLQAGGLMTASSPGHCTLDDVDKLASKQAVLL-QCMQSGEINMPLPGAFSTFLAQPSIIACANPQRGQYDEGRYLLQNIHIVPSLLKEFHLVYVLLDKPSVVRDISLTAHVRALHAG---------AKKRAQIAARYALKPKTSDSMCEG---TFY--DVRADDDS----EDNDSIMQ----------------QDYDLDKRLELQEEDA-ELDLLPPILIKKFLAYARQNVNP----LLNEAASRSIERFFMELREGGRTGGG--------------------------EDT--------------------EQSQLGSGQLLGLIHLSQARARLDLSNVVTPQHVRDVIALLTESIT------------------ Drosophila_virilis_MCM5 ANPTNIRELKSDSVSRLVKIAGIIVAASGIQAKATRMSIMCRSCSTVIPNLKINPGLEGYALPRKC-TTEQAGRPKCPLDPF-FIMPDKC---KCVDFQTLKLQE--LPDFVP-QGEIPRHLQLFCD-RSLCERVVPGNRVLIQGVYSIRKVGKPSRQDGREKA---------VLGVRAPYMRVVGITV------------------DAEGAGAVSRYTNISTEEEENFRRIAAS--SDIYDRLSKSLAPSIFGSDDIKKAITCMLFGGSRKRL-----PDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSG--KGSSAAGLTASVMKDPHTRNFIMEGGAMVLADG-GVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTK-GEENIDFMPTILSRFDMIFIVKDVHDETRDITLAKHIINVHLS----------------SNKSAPFEPEEGE---------------------------------------------------------------------ISLPMFKKYIHYCRTHCGP----RLSEAAGEKLKSRYVLMRCGAGQQEKSAD--------------------------------------------KRHCIPITVRQLEAVIRISESLAKMRLLPFVMDDHVNEALRLFQVSTL------------------ Drosophila_virilis_REC VPVELVSSITHARVDSLFAVRGIVRSVGEPTLGLAWQAFRCTRCRT-EQTLRQRGNY--TPRPYHC------LKPRCGAKDN-FLALRSSPYTRLSVRQIIRLEESSLALLTDYDSTLPGELDIELR-HDLVDAVHVGQEIIVTGVVKLRE----LCDNSEQPSTSVGAATTTASGNLQVYLRACSVQQ------------------------ARHVKLEFSERDLEAISTINTE--PNCFKLLVQSLAPELHGHELAKAACLLSLLG------------------ENINVLLVGDPGIGKSMMLQNCAQITERGAHVSG--KRGAQAANQLGISFCGRNKR-VMDAGALLMAGTAGTCLVDGVDKLASKQTLLL-QCMQAGELNMPLPGLFASFEAQPAIIACANPQRGQYDQARYLLQNIRITAALLKEFHLVYVLLDRQSTTRDKSLTEHVRALHAG---------SKRREQIAARYALKPKKSESVCEA---TFH-------DAPVVPNDDKDSIMQ----------------QDYDLDKRLECNVLEP-ELDLLPPILMKKFIAYARQNVKP----LLNDEAANIIKWHFMELCRRSELE--------------------------------------------------HEQSQIGMGQLLGLISLSQARARLDLSSVVTPLHVRDVIAVLTESMA------------------ Glossina_morsitans_MCM5 AIPTNVRDLKSDCVSRLVKIAGIIVSASGIKAKATRISIMCRSCGVVIPNLKINPGLEGYMLPRKC-TTEQAGRPRCPLDPF-FIMPEKC---RCVDFQILKLQE--LPDFVP-QGEIPRHLQLFCD-RTLCERVVPGNRVLIQGIYSIRKVGKPTRQDGREKS---------VVGVRAPYMRVVGITV------------------DTEGSGAISRYSNITSEEEETFRCMAAS--PTLYDRLASSLAPSIFGSHDIKRAITCMLFGGSRKRL-----PDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIGIYTSG--KGSSAAGLTASVMRDPSTRNFVMEGGAMVIADG-GIVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTINSRCSVLAAANSIFGRWDETK-GEENIDFMPTILSRFDMIFIIKDIHDEARDITMAKHIINVHLS----------------SNKSAPNEPAEGE---------------------------------------------------------------------ISLPLFKKYIYYCRTHCGP----RLSEEAGEKLKNRYVLMRNGAGQQEKSSD--------------------------------------------KRLSIPITVRQLEAIIRITESLAKMRLLPFATDEHINEALRLFQVSTL------------------ Glossina_morsitans_REC QPMEQIPLME---IDQLYCVRGVVKSMGEVEAYASWVAYKCSRCKQ-DQALRQGDLQ--PNRPTSC------KTLGCMAKQG-FIEMRSSPFTRLKVKQIIELAEARLDVLHYEDTSIDYCLEAELH-YDLVDSVVIGEEVVMTGVLKMRS----LQEVAGGRQMKV-------------YLKVCSITK------------------------AERAPHHFNETDIQAITTINGA--ADSFKLLVHSLAPEVYGHEVVKAGALLSIIGGSGSQL---------HDEEDINVLLIGDPGVGKSRIAKMCAQISQKGNEISSIKQGLAGCGPKLTATVKGRLNS-ILESGGLLRGNK-GHCSIDDIDRLSSQQDALV-SLMQTQIVAIPTVAIYANLKASTSVIATANSMHGHYDQSKLLTNNIRISPTLLNEFHLIFLMLDKPNKEGDAIFSEHVRAVHGG---------FKKNSTIMNKFNTLPKFNNTVSEK---DWS----------------VENI------------------KSTDLIERLKLRADEGEELDLIPSMLLKKFA-YARQQVKP----LFIAEAAEDLQKFYMEIRGQQQSE---------------------------------------------------------EDHLAGLIRLCQARARIDFSTEVTKVHVYDVISLVKYSNA------------------ Homo_sapiens_MCM5 ASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKC-NTDQAGRPKCPLDPY-FIMPDKC---KCVDFQTLKLQE--LPDAVP-HGEMPRHMQLYCD-RYLCDKVVPGNRVTIMGIYSIKKFG-LTTSRGRDRV---------GVGIRSSYIRVLGIQV------------------DTDGS-GRSFAGAVSPQEEEEFRRLAAL--PNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRL-----PDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSG--KGSSAAGLTASVMRDPSSRNFIMEGGAMVLADG-GVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETK-GEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLH----------------VSALTQTQAV--EGE---------------------------------------------------------------------IDLAKLKKFIAYCRVKCGP----RLSAEAAEKLKNRYIIMRSGARQHERDSD--------------------------------------------RRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTL------------------ Homo_sapiens_MCM8 EPLTQLKNVRANYYGKYIALRGTVVRVSNIKPLCTKMAFLCAACGE-IQSFPLPDGK--YSLPTKC------PVPVCRGRS--FTALRSSPLTVTMDWQSIKIQELMSDDQRE-AGRIPRTIECELV-HDLVDSCVPGDTVTITGIVKVSN-----AEEGSRNKN--------DKCMFLLYIEANSISN-----------SKGQKTKSSEDGCKHGMLMEFSLKDLYAIQEIQAE--ENLFKLIVNSLCPVIFGHELVKAGLALALFGGSQKYA---DDKNRIPIRGDPHILVVGDPGLGKSQMLQAACNVAPRGVYVCG--NTTTTSGLTVTLSKDSSSGDFALEAGALVLGDQ-GICGIDEFDKMGNQHQALL-EAMEQQSISLAKAGVVCSLPARTSIIAAANPVGGHYNKAKTVSENLKMGSALLSRFDLVFILLDTPNEHHDHLLSEHVIAIRAG----------KQRTISSATVARMNSQDSNTSVLEVV-----------------------------------------SEKPLSERLKVVPGET--IDPIPHQLLRKYIGYARQYVYP----RLSTEAARVLQDFYLELRKQSQRL---------------------------------------------------NSSPITTRQLESLIRLTEARARLELREEATKEDAEDIVEIMKYSML------------------ Methanopyrus_kandleri_MCM -----MFRLGTTPRATTYDPDARIGEVASRFGLPTRVLIEIVRTESFQRSLARVTSGKPVVLDLRELDSDLASWIATHARLVEPALRELVRTVAPDVEPRVRFRG--LPHRFR-RVERIRPMDGALISIEGVVREVRGAERLEHAIVDTGSELVAVRLHGHRLGPG-------LRVEILGIVRSATLDA------------------LEVHKKDPIPEVHPDPAELEEFRELADK---DPLTTFARAIAP-LPGAEEVGKMLALQLFSCVGKNS------------ERLHVLLAGYPVVCSEILHHVLDHLAPRGVYVDL--RRTELTDLTAVLKED---RGWALRAGAAVLADG-GILAVDHLEGAPEPHRWALMEAMDKGTVTVDG----IALNARCAVLAAINP--GEQWPSDPPIARIDLDQDFLSHFDLIAFLGVDPRPGEPEEQDTEVPSYT--------------------------------------------------------------------------------------------------------LLRRYLLYAIREHPAP---ELTEEARKRLEHWYETRREEVEERLGMG----------------------------------------------LPTLPVTRRQLESVERLAKAHARMRLSDDVEPEDVDIAAELVDWYLETAMQIPGGDEIRISSLKP Strongylocentrotus_purpuratus_MCM5 ANPIAIRNLKSEEVSKLIKIPGIVIAASAIRAKATRITIQCRSCRNYMPNLTLKPGLEGYSMPRKC-NTDQAGRPKCPLDPF-FIVPDKC---KCVDFQILKLQE--APEDVP-NGEMPRHLQLFCD-RYLCEKVVPGNRVTIIGVYSIKKAGPVSKRTRKTKV---------TVGIRSPYIRVVGIEV------------------DQEGLGRTSTAHHITPQEEEEFRRLSAN--PNIYEIIARSIAPSIFGSIDVKKAISCLLFGGSRKRL-----PDGLMRRGDINLLMLGDPGTAKSQLLKFVERVSPIGVYTSG--KGSSAAGLTASVMRDPATRNFVMEGGAMVLADG-GVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDDTK-GDENIDFMPTILSRFDMIFIIKDEHDEARDMRLAKHVMGVHMN----------------AQVSAAALAQEGE---------------------------------------------------------------------LSLTFLKKYIGFIRNKCGP----RISDAAADKLKNRYVLMRSGARDHEMQTD--------------------------------------------KKTSIPITVRQLEAIIRIAESLAKMRLKPFASEEDVDEALRLFQVSTL------------------ Strongylocentrotus_purpuratus_MCM8 EPTTAFKNLKANCYGKFVSVKGTVVRVSNIRPLCTKMAFQCNTCGD-IQIVHLPNGK--YILPTKC------LAPECRGRS--FVPKQKSPLTETADWQTIKLQEIVMDEQRE-AGRIPRTVECELM-HDLVDNCVPGDTVTVSGIVKVSN----VDEGKGRNK---------DKCMFLLYIHANSLSN----------LKKSKKGSDVSGGIGAGAAVDFSIKELYAIQEIQSQ--ENLFKLIIGSLCPTIYGHELVKAGLILGLLGGTHKYT---NDKNRIPVRGDPHILVVGDPGLGKSQMLQAASNVAPRGVYVCG--NTTTTSGLTVTLTKDGSSGDYSLEAGALVLGDQ-GCCCIDEFDKMGSQHQALL-EAMEQQSISIAKAGVVCSLPARTSILAAANPVGGHYNKAKTVSENLKMSGPLLSRFDLVFILLDKPDEEMDSLLSEHVMALHAG----------KQKAMSGVRVTRHPSGSITTSEDEDA------------------------------------RRLWESERPLSERLKVGRGEA--FDPIPSQLLRKYIAYARKYVYP----KLMPEAATVLQNFYLELRRQHQGM---------------------------------------------------DSTLITTRQLESLMRLTEARARLELREQATLADAEDVVELMKFSMI------------------ ; END; [ The following blocks are output data for analysis step 10164 ] BEGIN TREES; TITLE 'MCM5 + MCM8 metazoans MLT'; LINK TAXA = TaxaForAnalysisStep10164; TREE 'MCM5-MCM8 ML' = [&R] ((((((Homo_sapiens_MCM8:0.11079373,Danio_rerio_MCM8:0.12659203)0.8940:0.0592661,Strongylocentrotus_purpuratus_MCM8:0.16913702)0.9570:0.11348575,Dictyostelium_discoideum_MCM8:0.44132737)0.4970:0.09632478,Arabidopsis_thaliana_MCM8:0.52818436)0.7260:0.10908799,((((Drosophila_melanogaster_REC:0.2159182,Drosophila_pseudoobscura_REC:0.12415931)0.4550:0.08404008,Drosophila_virilis_REC:0.21230169)1.0000:0.43391146,Glossina_morsitans_REC:0.58503768)1.0000:0.66928667,(Anopheles_gambiae_MCM8:0.26969282,(Aedes_aegypti_MCM8:0.10022856,Culex_quinquefasciatus_MCM8:0.29152596)0.9680:0.08977074)0.8560:0.16180074)0.9090:0.18889281)0.9650:0.44509851,((((Homo_sapiens_MCM5:0.11600401,Danio_rerio_MCM5:0.14997354)0.9790:0.06673105,Strongylocentrotus_purpuratus_MCM5:0.12324)0.8210:0.0415688,((((Drosophila_melanogaster_MCM5:0.02191323,Drosophila_pseudoobscura_MCM5:0.02336376)0.8680:0.02592887,Drosophila_virilis_MCM5:0.03813234)0.9640:0.02573063,Glossina_morsitans_MCM5:0.07699501)1.0000:0.05115367,(Anopheles_gambiae_MCM5:0.05872628,(Aedes_aegypti_MCM5:0.02960792,Culex_quinquefasciatus_MCM5:0.04253459)0.5370:0.01828838)0.9980:0.06322941)1.0000:0.1113423)1.0000:0.16679895,(Arabidopsis_thaliana_MCM5:0.3356605,Dictyostelium_discoideum_MCM5:0.37998073)0.5540:0.11720663)0.9940:0.56867385,Methanopyrus_kandleri_MCM:1.8825241); [! TreeBASE tree URI: http://purl.org/phylo/treebase/phylows/tree/TB2:Tr57563] END;