#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 19, 2025; 18:35 GMT TreeBASE (cc) 1994-2008 Study reference: Vastermark A., Rask-andersen M., Sawant R.S., Reiter J.L., Schioth H.B., & Williams M. 2013. Insulin receptor-like ectodomain genes and splice variants are found in both arthropods and human brain cDNA. Journal of Systematics and Evolution, . TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S13882] [ The following blocks are input data for analysis step 10803 ] BEGIN TAXA; TITLE TaxaForAnalysisStep10803; DIMENSIONS NTAX=46; TAXLABELS Aedes_aegypti_AAEL_INSR_L1 Aedes_aegypti_AAEL_INSR_L2 Aedes_aegypti_AAEL_TRUNC_L1 Aedes_aegypti_AAEL_TRUNC_L2 Anopheles_gambiae_AGAP_INR_L1 Anopheles_gambiae_AGAP_INR_L2 Anopheles_gambiae_AGAP_TRUNC_L1 Anopheles_gambiae_AGAP_TRUNC_L2 Culex_quinquefasciatus_CPIJ_TRUNC_L1 Culex_quinquefasciatus_CPIJ_TRUNC_L2 Danio_rerio_Dre_insra_L1 Danio_rerio_Dre_insra_L2 Danio_rerio_Dre_insrb_L1 Danio_rerio_Dre_insrb_L2 Daphnia_pulex_BR000948_DAPH_L1 Daphnia_pulex_BR000948_DAPH_L2 Daphnia_pulex_DAPH_EGFR_L1 Daphnia_pulex_DAPH_EGFR_L2 Daphnia_pulex_Dappu1_L1 Daphnia_pulex_Dappu1_L2 Daphnia_pulex_Dappu3_L1 Daphnia_pulex_Dappu3_L2 Daphnia_pulex_Dappu4_L1 Daphnia_pulex_Dappu4_L2 Drosophila_melanogaster_CG10702_L1 Drosophila_melanogaster_CG10702_L2 Drosophila_melanogaster_CG3837_L1 Drosophila_melanogaster_CG3837_L2 Drosophila_melanogaster_Dme_EGFR_L1 Drosophila_melanogaster_Dme_EGFR_L2 Drosophila_melanogaster_Dme_InR_L1 Drosophila_melanogaster_Dme_InR_L2 Glossina_morsitans_TMP002932_TSE_TRUNC_L1 Glossina_morsitans_TMP002932_TSE_TRUNC_L2 Homo_sapiens_Hsa_INSR_L1 Homo_sapiens_Hsa_INSR_L2 Homo_sapiens_Hsa_INSRR_L1 Homo_sapiens_Hsa_INSRR_L2 Tribolium_castaneum_BR000971_TRIB_L1 Tribolium_castaneum_BR000971_TRIB_L2 Tribolium_castaneum_TC010784_INSR_L1 Tribolium_castaneum_TC010784_INSR_L2 Xenopus_tropicalis_Xtr_INSR_L1 Xenopus_tropicalis_Xtr_INSR_L2 Xenopus_tropicalis_Xtr_INSRR_L1 Xenopus_tropicalis_Xtr_INSRR_L2 ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M15943] TITLE 'Insulin receptor-like ectodomain genes and splice variants are found in both arthropods and human brain cDNA'; LINK TAXA = TaxaForAnalysisStep10803; DIMENSIONS NCHAR=133; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 ] [ . . . . . . . . . . . . . ] Aedes_aegypti_AAEL_INSR_L1 CVVVEGFVHILLIDKYIDS-SFENYS---------------FPLLTEITEYLLLFRVNGLKSLRRLFPNLAVIRG---------DALVGD-YAMVIYELMHIEEIGLISLMD----ITRGGVRIEKNPKLC-- Aedes_aegypti_AAEL_INSR_L2 CEIIDGSLEIQLRS--RGGENIVKELENF------------LSSITEIKGYLKVVRSYPLLSLG-FLKKLKIIHGK---------GNKVSNSSLYVVENQNLQELFDHNVTI-----GEGKLFFFNNPMLC-- Aedes_aegypti_AAEL_TRUNC_L1 CTVITGFLQLVLIERVPHEEFVKYN----------------ISKLREVTGFVLFFHVYNLRSLRDLFPSLMVIRG---------RTLIGN-YALIFYDLPDLEEIGLKNLIA----IQDGFVFVQHCPKLC-- Aedes_aegypti_AAEL_TRUNC_L2 CTIINGTLQIRMN---EDHPHLIEELRRT------------LGRIQEIMGYLKVYRSNTLPSLE-FLENLEIIHG--------QWELGHGKYSLMIYENANLQKLWNYGDYPMSLKLVTGSMYFVYNPLLC-- Anopheles_gambiae_AGAP_INR_L1 CRVVEGFVQIMLIDKYGND-SFDNYT---------------FPLLTEITGYLLLFRVNGLQTLGQLFPNLTVIRG---------SELANN-YALVVYELMHIKELGLTSLID----IQRGGVRIEKNPNLC-- Anopheles_gambiae_AGAP_INR_L2 CTIIQGSLSIRLRQ--LGGENVVRELEKV------------LYSIEEIYGYLTIVRSYALMSLG-FFRNLKIIHG----------TVLNANLSLSVIDNQNLQELWNQNVTI-----KRGNVRFNDNPMLC-- Anopheles_gambiae_AGAP_TRUNC_L1 CTVINGFLQMVLIERVPSEEFEKYS----------------CKHLREVTGYMLFFRVINLVTLRRLFPQLAVIRG---------QQLIGN-YALVFYYMENMIELGLKNLVA----IQRGFVYTLHCPQLC-- Anopheles_gambiae_AGAP_TRUNC_L2 CTIVNGTLHIRLK---EDHPNLVDELRNG------------LSDVEEIMGNLKVFRSTFIPSLE-FLANLQIIHG--------VDVNENAKFSLMVYENSNLQRLWNFEQKTN-LRLDNGGMYFANNKLLC-- Culex_quinquefasciatus_CPIJ_TRUNC_L1 CTVITGFLQLVLIERVPQEDFAEYR----------------FDKLREVTGFILFFRVFNLITLRDMFPNLMMIRG---------QKLIGN-YALIFYDLRDFHEIGLKNLYS----IQRGFVYSQWCPNLC-- Culex_quinquefasciatus_CPIJ_TRUNC_L2 CTIINGTLQIRLLDDHPNVLEELRENLGGIEEIM--GYLKVYRSNTEVTGFILFFRVFNLITLRDMFPNLMMIRG---------QKLIGN-YALIFYDLRDFHEIGLKNLYS----IQRGFVYSQWCPNLC-- Danio_rerio_Dre_insra_L1 CTVIEGHLKILLMFTTKPE-DFRGLS---------------YPKLTVVTDYLLLFRVYGLESLSDLFPNLTVVRG---------NNLFFN-YALVLFEMLQLKEIGLHSLMN----ITRGAVRVEKNPDLC-- Danio_rerio_Dre_insra_L2 CTVINGSLVINIR----GGNNIAAELEAN------------LGQLEEITGYLTVRHSYALVSLS-FLRKLRIIHG---------ETQEVGNYSFYALDNQNLRQLWDWSKHN--LTIQQGRMFFHHNSKLC-- Danio_rerio_Dre_insrb_L1 CTVIEGHLKILLMFKTTQE-DFRGLS---------------FPKLVMVTDYLLIFRVYGLESLGSLFPNLTVIRG---------SNLFFN-YALVMFEMIQMKEIGLHSLTN----ITRGAVRIEKNPNLC-- Danio_rerio_Dre_insrb_L2 CTVLNGSLIIKIS----GGNSIAAELESS------------LGQLEEITGYLTIRRAYALVSLS-FLRKLHLIRG---------ETLDGGNYSFHAMDNQNLRQLWDWNKHN--LTILKGRMKFIQNGKLC-- Daphnia_pulex_BR000948_DAPH_L1 CTYVDGNLELTWLQEESLDLTFLQHIR-------------------EVTGYVLISHVEIRRFVLPALQIIRGRTLFK-------YNTHGDEGFALIVILSKMHSLETPALRD----ILAGSCGMFNNYNLC-- Daphnia_pulex_BR000948_DAPH_L2 CTVIEGSLAIIDHSFTGFQHIYPNFTF--------------------------------DFKNLFYFRNLEKIGGSQ-------LTE---YFSSLFIYKTSLQSLNLRSLKT----INFGSATLLGNKQLC-- Daphnia_pulex_DAPH_EGFR_L1 CTYVDGNLELTWLQDEHLDLTFLQHIR-------------------EVTGYVLISHVDVRRIVLPALQIIRGRTLFK-------LNVH-DEEFALVVTLSKMHNLEMPALRD----ILAGSCGLFNNYNLC-- Daphnia_pulex_DAPH_EGFR_L2 CTVIEGSITILDHSFAGFQQIYPNFTFGPRYPRLHPDRLEIFATLQEITGFINVQASHPEFRNLSYFRNLETIGGRQ-------LTE---YFSALYIVKTSLNSLHLRSLKM----IRAGSVTVLENKELC-- Daphnia_pulex_Dappu1_L1 CRVVEGFLHIVLMENLDFASDLNNRS---------------FPALREITGYLLFYRVFGLRSIGQLFPNLAVIRG---------QQLLFD-FSFVVYELMQLQEIGLKSLAE----LQRGSVLIEK-PNLC-- Daphnia_pulex_Dappu1_L2 CTTIDGDLEMQIK----GGDNIIQELERS------------LGSIEVIKGVLKITRSFPILSLS-FFKSLRTITGKPETLHSSGSKNFDDEYALTVQDN--LQQLWPKTQNL----TIHKKMLFHFNPKLC-- Daphnia_pulex_Dappu3_L1 CRVVEGFLHIVMEN-LDFASDLNNRS---------------FPALREITGYLLFYRVFGLRSIGQLFPNLAVIRG---------QQLLFD-FSFVVYELMQLQEIGLKSLAE----LQRGSVLIEKNPNLC-- Daphnia_pulex_Dappu3_L2 CTTIDGDLEMQIK----GGNDIIQELERS------------LGSIEVIKGVLKITRSFPILSLS-FFKSLRTITGKPETLHSSGSKNFDDEYALTVQDNQNLQQLWPKTQNL----TIHKKMLFHFNPKLC-- Daphnia_pulex_Dappu4_L1 CRVVEGNLHIVLMENLDFASDLNDRS---------------FPALREITGYLLFYRVLGLRSIGQLFPNLAVIRG---------QQLLFD-FSFVVY-LMHLQEIGLKSLAE----LQRGSVLIEKNPNLC-- Daphnia_pulex_Dappu4_L2 CTTIDGDLEMHMI----RGNNIIQELERS------------LGSIKMIKGVLKITSSFPIFSLS-FFKSLRNITGKPITIHSSGSNNFDDEYALIVQNNQNLQQLWPKTQNL----TIHKKMLFHSNPKLC-- Drosophila_melanogaster_CG10702_L1 CTVVTGYVMITLIT-----IEQRCN-----------FSEYSYPLLTEITEFMIFTDVRGLVNITEMFPHLTVIRG---------RRLFLN-YALGVTNMHELEQLVFPKLVA----IQRGQVYIGSCPKLC-- Drosophila_melanogaster_CG10702_L2 CQIFNGSLVITIR-----NKVNETQLYQS------------FTSMREVRGHVKVYRSSQLRSLQ-FLRNLERVHG---------DPLENRHYSFILYDNKELSELWTPSRQLE---FMEGGMFMHRNNKLC-- Drosophila_melanogaster_CG3837_L1 CTHVVGHVRLAYVDLTDVSGNYSLDS--------------LASNVTEISDYLMVYRCTGLISLQSIFPRLRIIRG---------QELLFDQYSLVVYENRNLRELGLVELLR----IQSGFIRVESNPLLC-- Drosophila_melanogaster_CG3837_L2 CVTINGSLTIELTNIKEK---IVDALENA------------LASVKEITGYLKVIHSAQLMSLT-FLQNLDAIRGDK---------LVENKYALYVVNNYHLEHIWPPNHLV---IIQRGTLFFHLNPRLC-- Drosophila_melanogaster_Dme_EGFR_L1 CTYVDGNLELTWLPNENLDLSFLDNIR-------------------EVTGYILISHVDVKKVVFPKLQIIRGRTLFS-------LSVE-EEKYALFVTYSKMYTLEIPDLRD----VLNGQVGFHNNYNLC-- Drosophila_melanogaster_Dme_EGFR_L2 CTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQ-------LMES--MFAALAIVKSSLYSLEMRNLKQ----ISSGSVVIQHNRDLC-- Drosophila_melanogaster_Dme_InR_L1 CTVIEGFLLIDLINDASPL----NRS---------------FPKLTEVTDYIIIYRVTGLHSLSKIFPNLSVIRG---------NKLFDG-YALVVYSNFDLMDLGLHKLRS----ITRGGVRIEKNHKLC-- Drosophila_melanogaster_Dme_InR_L2 CTIITGTEPLTISIKRESGAHVMDELKYG------------LAAVHKIQSSLMVHLTYGLKSLK-FFQSLTEISGDPP--------MDADKYALYVLDNRDLDELWGPNQTV---FIRKGGVFFHFNPKLC-- Glossina_morsitans_TMP002932_TSE_TRUNC_L1 CTVITGYMLIVLLPRVNQRVHEVCN-----------FSKYQFPLLREITDFLIFHEVRNITTIADMFPNLTVIRG---------QRLFLN-YALGVTSMKDLNTLEFRSLIA----IQRGHVFIGTNPKLC-- Glossina_morsitans_TMP002932_TSE_TRUNC_L2 CQILNSSVFLTIR-----NRINENDLYQS------------FADVKEIKGHLNIYKNTYLSSLK-FLKGLRKIDG---------KNSKDHHFSLTLYDNKNLRELWSPSEDLE---LTRGGMYVHANYKLC-- Homo_sapiens_Hsa_INSR_L1 CSVIEGHLQILLMFKTRPE-DFRDLS---------------FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRG---------SRLFFN-YALVIFEMVHLKELGLYNLMN----ITRGSVRIEKNNELC-- Homo_sapiens_Hsa_INSR_L2 CTVINGSLIINIR----GGNNLAAELEAN------------LGLIEEISGYLKIRRSYALVSLS-FFRKLRLIRG---------ETLEIGNYSFYALDNQNLRQLWDWSKHN--LTITQGKLFFHYNPKLC-- Homo_sapiens_Hsa_INSRR_L1 CSVVEGHLQILLMFTATGE-DFRGLS---------------FPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRG---------TRLFLG-YALVIFEMPHLRDVALPALGA----VLRGAVRVEKNQELC-- Homo_sapiens_Hsa_INSRR_L2 CTHVEGSLILNLR----QGYNLEPQLQHS------------LGLVETITGFLKIKHSFALVSLG-FFKNLKLIRG---------DAMVDGNYTLYVLDNQNLQQLGSWVAAG--LTIPVGKIYFAFNPRLC-- Tribolium_castaneum_BR000971_TRIB_L1 CRVIDGALQIVLMENFDAT-DYINIS---------------FAKLVEITEYLLIYRVMGLTSLDLIFPKLVSIKG---------SSLFLG-HSLVVYDLPNLEEIGLQKLQS----IDNGNVKIANCPQLC-- Tribolium_castaneum_BR000971_TRIB_L2 CTHINGSLELSLV-----GSVSLSDLERT------------LGKIVSISKYLKITRSHKLTSLQ-FFDKLRTIKG---------DQLWSRYYSFYVTKNQNLQQLFGGKFKLN---IKNGTVIFQDNPHLC-- Tribolium_castaneum_TC010784_INSR_L1 CHVVEGFVQILLFDNVNET-ELSLLS---------------FPNLTEITDYLLLYRVNGLRSIGQLFPNLSVIRG---------RSTFYT-YSFVVFEMSSLQEIGLYSLTD----ITRGLIRIDKNPSLC-- Tribolium_castaneum_TC010784_INSR_L2 CTHITSSLEIQIR----GGRNVVNELEES------------LGMIEEIDGYLKVVRSFPLVSLN-FLKNLKVIHG---------RQLESQKYVFVVLDNQNLQELWNWENNKT-LKIDTGRLFFHFNPKLC-- Xenopus_tropicalis_Xtr_INSR_L1 CTVIEGHLQILLMFTSKPE-NFRGLR---------------FPKLTMITDYLLLFRVYGLESLKDLFPNLTVIRG---------THLFFN-YALVIFEMVHLKEIGLYNLMN----ITRGSVRIEKNNELC-- Xenopus_tropicalis_Xtr_INSR_L2 CTVVNGSLIINIRGGSKYNPVIDSVMYR---------------VIYSVGFLKVEKLDRSVQGFRGITLLLLEIVT-----------LEVQLSFIYILYKVSLMVLWPVNSVK---LYVLMKIYFECNRKACLC Xenopus_tropicalis_Xtr_INSRR_L1 CTVIQGNLQILLMFSTKPE-DFRGLR---------------FERLTMITEYLLLFRVYGLESLRDLFPNLSIIRG---------TDLFFH-YSLVIFEMPHLRDIGLYSLTN----ILNGAVRIERNQELC-- Xenopus_tropicalis_Xtr_INSRR_L2 CTNIEGNLILNIR----RGHNLASELQQS------------LGLIETITGFLKIKHSFALVSLS-FFKNLKLIRG---------DTMVDGNYTLYILDNQNLLQL--WTPES--LSIPVGKLYFAFNPKLC-- ; END; [ The following blocks are output data for analysis step 10803 ] BEGIN TREES; TITLE RAxML_bipartitions_INSRR; LINK TAXA = TaxaForAnalysisStep10803; TREE tree_1 = [&R] (((Drosophila_melanogaster_Dme_EGFR_L1:1.2360325349902723E-6,(Daphnia_pulex_BR000948_DAPH_L1:0.14649483708077327,Daphnia_pulex_DAPH_EGFR_L1:1.2360325349902723E-6):0.39893079494446937):1.143597917854076,((Xenopus_tropicalis_Xtr_INSR_L2:2.1186882255026207,Drosophila_melanogaster_Dme_InR_L1:1.2360325349902723E-6):0.3458538583104924,(Drosophila_melanogaster_CG3837_L1:0.9089244503391531,((Tribolium_castaneum_BR000971_TRIB_L1:0.5869836942691835,((Drosophila_melanogaster_CG10702_L1:0.3317356613052964,Glossina_morsitans_TMP002932_TSE_TRUNC_L1:0.1726371002841247):0.3554948617726925,(Anopheles_gambiae_AGAP_TRUNC_L1:0.304938555369741,((Culex_quinquefasciatus_CPIJ_TRUNC_L2:0.19940604767494774,Culex_quinquefasciatus_CPIJ_TRUNC_L1:1.2360325347682277E-6):0.1672940388918649,Aedes_aegypti_AAEL_TRUNC_L1:0.20107119497815806):0.04454906128139635):0.2826403206998114):0.32737145889398):0.08603157004976092,(((Anopheles_gambiae_AGAP_INR_L1:0.16108146985791238,Aedes_aegypti_AAEL_INSR_L1:0.19031519685317422):0.212171290314501,(Tribolium_castaneum_TC010784_INSR_L1:0.3086856509834921,(Daphnia_pulex_Dappu4_L1:0.0284034337535104,(Daphnia_pulex_Dappu3_L1:1.2360325345461831E-6,Daphnia_pulex_Dappu1_L1:1.2360325345461831E-6):0.012366112219205139):0.3140362252369857):0.1084775905101445):0.08392478305578921,((Danio_rerio_Dre_insrb_L1:0.12200178432574127,Danio_rerio_Dre_insra_L1:0.07293853026538644):0.05276888163530025,((Homo_sapiens_Hsa_INSR_L1:0.07966491942782383,Xenopus_tropicalis_Xtr_INSR_L1:0.03701061124374938):0.038960038371079975,(Homo_sapiens_Hsa_INSRR_L1:0.24513827699208823,Xenopus_tropicalis_Xtr_INSRR_L1:0.15621257091678764):0.08545480522447946):0.04959001477104774):0.28247885752618274):0.10743614256169609):0.08412791868850356):0.0387156870472829):0.39139014413142137):0.15404865067678827,((Drosophila_melanogaster_Dme_EGFR_L2:1.2360325349902723E-6,(Daphnia_pulex_BR000948_DAPH_L2:0.31215713057206873,Daphnia_pulex_DAPH_EGFR_L2:1.2360325349902723E-6):0.51310510600453):1.1201949928907857,(Drosophila_melanogaster_CG3837_L2:0.4967161943469556,(Drosophila_melanogaster_Dme_InR_L2:0.6212854998491919,(((Anopheles_gambiae_AGAP_TRUNC_L2:0.336841078167033,Aedes_aegypti_AAEL_TRUNC_L2:0.3245815962460501):0.5052866195243757,(Drosophila_melanogaster_CG10702_L2:0.37289639832863886,Glossina_morsitans_TMP002932_TSE_TRUNC_L2:0.4351510371262979):0.3794712482435676):0.14371501965627442,((Daphnia_pulex_Dappu1_L2:1.2360325349902723E-6,(Daphnia_pulex_Dappu3_L2:0.008995203195471202,Daphnia_pulex_Dappu4_L2:0.14836000387901382):0.008979630644718295):0.431208056181128,((Anopheles_gambiae_AGAP_INR_L2:0.36148764257585864,Aedes_aegypti_AAEL_INSR_L2:0.24876152946711683):0.15520217520287805,((((Homo_sapiens_Hsa_INSRR_L2:0.19817832318885165,Xenopus_tropicalis_Xtr_INSRR_L2:0.06121043413994176):0.36713127319541217,(Homo_sapiens_Hsa_INSR_L2:1.2360325349902723E-6,(Danio_rerio_Dre_insra_L2:0.06317525776838284,Danio_rerio_Dre_insrb_L2:0.22859213791481237):0.12998848884684655):0.1452459374476276):0.0957236706065916,Tribolium_castaneum_BR000971_TRIB_L2:0.8054098559529033):0.15816522951919287,Tribolium_castaneum_TC010784_INSR_L2:0.29343154729231946):0.1120908888283676):0.023273134352175706):0.20790351624882386):0.15579965410165464):0.11027649889737812):0.2953474880184328):0.3080973013535764); [! TreeBASE tree URI: http://purl.org/phylo/treebase/phylows/tree/TB2:Tr60720] END;