#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 20, 2025; 4:48 GMT TreeBASE (cc) 1994-2008 Study reference: Belahbib H., Renard E., Santini S., Jourda C., Clavery J., Borchiellini C., & Le bivic A. 2018. New Genomic Data and Analyses Challenge the Traditional Vision of Epithelium Evolution in Sponges and Ctenophores. BMC Genomics, . TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S22408] [ The following blocks are input data for analysis step 22816 ] BEGIN TAXA; TITLE TaxaForAnalysisStep22816; DIMENSIONS NTAX=60; TAXLABELS 'A.queenslandica_KPCE' 'A.queenslandica_KPC_A-B-G' 'A.queenslandica_PKCD' 'A.queenslandica_aPKC' 'A.vastus_KPCE' 'A.vastus_KPC_A-B-G' 'A.vastus_PKCD' 'A.vastus_aPKC' 'D.melanogaster_APKC' 'D.melanogaster_KPC3' 'D.rerio_PKCB' 'D.rerio_PKCD' 'D.rerio_aPKC-iota' 'D.rerio_aPKC-lambda' 'D.rerio_aPKC-zeta' 'G.cydonium_KPC_A-B-G' 'L.complicata_KPCE' 'L.complicata_KPC_A-B-G' 'L.complicata_PKCD-1' 'L.complicata_PKCD-2' 'L.complicata_aPKC' 'M.leidyi_KPC_A-B-G' 'M.leidyi_aPKC' 'M.musculus_KPCA' 'M.musculus_KPCB' 'M.musculus_KPCE' 'M.musculus_KPCG' 'M.musculus_KPCI-iota' 'M.musculus_PKCD' 'M.musculus_aPKC-lambda' 'M.musculus_aPKC-zeta' 'N.vectensis_KPCE' 'N.vectensis_PKCD' 'N.vectensis_aPKC' 'O.carmela_KPCE' 'O.carmela_KPC_A-B-G' 'O.carmela_PKCD' 'O.carmela_aPKC' 'O.lobularis_KPCE' 'O.lobularis_KPC_A-B-G' 'O.lobularis_PKCD' 'O.lobularis_aPKC' 'O.minuta_KPCE' 'O.minuta_KPC_A-B-G' 'O.minuta_PKCD' 'O.minuta_aPKC' 'P.ficiformis_KPCE' 'P.ficiformis_KPC_A-B-G' 'P.ficiformis_PKCD' 'P.ficiformis_aPKC' 'S.ciliatum_KPCE' 'S.ciliatum_PKCD' 'S.ciliatum_aPKC' 'S.domuncula_KPC_A-B-G' 'S.domuncula_PKCD' 'S.raphanus_KPC_A-B-G' 'S.raphanus_PKCD' 'T.adhaerens_KPCE' 'T.adhaerens_KPC_A-B-G' 'T.adhaerens_aPKC' ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M45623] TITLE Character_Matrix_figure_3_tree; LINK TAXA = TaxaForAnalysisStep22816; DIMENSIONS NCHAR=1083; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 ] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] 'A.queenslandica_KPCE' MAGAG----------------GNPDTFTGLVSMTILEAQNLKSVT------LPGGHKLSNKDFDPYCVVDFDDIYFG------KTTHKT--NTYCPVWNELVEEP-VEDASRMQIALFHAS---TIPPNPFIAHVQVPVSEIRLT--------KEDEFTLELEPEGSIRFRIQFQEKWGSLA------------------------------KKEFHVRSQ---VIK--GHRGAV--R-RKIHIVNAHKFMATYLRQFTFCAHCRDFIWGLVNKQGYQCQVCSMVVHKRCHKSIIT--PCTGRK--ITEDE----------DTA-----KASARFSINVPHRFKVHNYKRPTFCSHCGSLLWGLYRQGLKCE--ACAINVHQRCEQFVAHSCGIDQVS----------------------------------------LAKMMSQMGVSADQLSLSG--SKRKS-VTSV--------KSEENGPL-----------------KPPDIPAPVR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QIKAPE------PA-----ALQKVVTLDDFKFLKVLGKGSFGKVLLAEMKN-SDRVYAIKVLRKDVI-QDDDIECVLTEKRVLAL-----ACRHPYLTSMHSCFQTEERLFFVMEYVNGGDLMFQIQRVRKFDEDRARFYSAEIILALLFLHNVGIIYRDLKLDNVLLDSDGHVKVADFGMCKENIK-DGRLTSTFCGTPDYIAPEILEEKDYGSSVDWWALGILMYEMMAGQPPFE---------ADNEDELFEAIRNDEVLYPVWLSREANSILRGFLTKNPARRLGCQPG-IGERQIKIHAFFRTIDWEKLEKRQIPPPFKPQVRGKRDFSNFDADFITEEPRLTPIESSALDNISQTEFKDFTYTNAEFVA------ 'A.queenslandica_KPC_A-B-G' MA----------------------------------------------------------------------------EGS-----------------------------------------------------------------------------------------------------------------------------------------------PVRRPKRRNAV--KQGKVVEIKGHKFVLTYFKQFTFCGHCTRFLWGLTGPQGYRCLSCDFTIHRRCLEYVSF--ICPGTS--LPAGLE-------------------------PRPHTFKTASFYHPTFCAHCGSMIYGLFNQGVRCS--DCGMTAHHRCQALVPRACGQDTQEKRGRIKVGFYTQRSTENNW--RINIEIIECRNLPPMDPNGLADPFVKVSLLDSDGKDKS--SMKQK-TERR---------------------------------EKTLDPKFDESFFF----------DVSEQDLN-------------------------NFVYVAVW-DWDRIGSNDFIGGMGLKVNDIIT--ETCEGQRIESWYKLLGDNISRRKSIRIISDEEAE----KLIDEYR------KTTRANKVATLKA---DIEALDL----------------------------------RRGSQLA-----PGS-----KDLPRMTLDDFKLLVVLGKGSFGKVFLAEHKG-SKETYAIKSLKKDLIVQEDDVECTLNERKVLAL-----QGKPPFLTSLHSCFQTKEHLFFVMEFVSGGDLMFHILEFGKFPENQTRFYAAEIVIGLNYLHEKGIVYRDLKLDNVMLDADGHIKIADFGLCKDGIN-ADNRTRTFCGTPDYIAPEIISYQPYDQAVDWWALGVLIFEMLIGRPPFD---------GDDDDQLFNNIMEKPVHYPRGMSENAKSVVQGFLTKHPRHRLGCDRH-KSPGDIKGHPFFASIDWEKLEAKELKPPYKPRIKSNKSHNNFDKEFTSEKCVLSPVDKHVIEAIDPEAFDGFSFTNPELYVPH---- 'A.queenslandica_PKCD' MS--------------------------AFLRLKLLKAEVAPAPGVA--------------RVDTFAAVSIKETEQSPQG--PVLVQKK--KTFYPEWGKCFDSH-LVTGRRMMVEVMDRA-----SPETKIAEMVVETEELSSICKEEPDPSSAINLALDLRPKGKLILQVKLYGQTSDCPA----------------------DRTPEHLES-LPKNAT---ALR--GRRNAIHLRQLSVCERKGHRFVKKFFRQPVYCSYCHEFLWGF-TKPGFQCQVCAYTSHVKCVESIIA--NCTGAT--VHAT-----------LSK-----NLKERFKIDMPHRFKPHSFLRPTFCDHCGQLMRGLFRQGVKCG--VCGVNCHSRCQPNIPNLCGVNERL----------------------------------------MAEALKDVDEVK---------KKRLS-SSSSAGSVVSP-KGGAGAIGGAAP-------------KPPLAAIPDD-----------------------------------------------HEIYMDVTQDMIK--------------------------------------------------------------------------------PTVPS--------RKGNGAAG----------------------------RAPPPPV-----PHK-----PAKPSYKLSDFQLIKVLGKGSFGKVLLAKLSKGNESYFAIKALKKDVVLEDNDVESTFVEKRILAL-----GSSHPFLTHLLCSFQTPSHLFFVMEYLNGGDLMFHIQVSHKFKLPRARFYAAEIICALQFLHSKGIIYRDLKLDNVLLDCDGHAKLADFGMCKEGVF-APNKTGTFCGTPDYISPEIVKNERYSYSVDFWSLGVLSYEMLTGQSPFS---------GDSEEELFDSICNCNVPFPSFLAPSSIDYLKKLLERDPEKRLGCMED---RMPIRSHPFFSPIDWVKLETRESEPPFKPKVKSPGDVSNFDDDFTFQEPNLTPCDNRLVQSIDQSNFRGFSYTNDRIKI------ 'A.queenslandica_aPKC' MG-------------------------DDIIPVRLSFRG---------------KDIKFS--LVPNLAVTDVSNEIR----KQCGLHSA--APFNLKYLDVENDP-----------------------------VSVS-----------------------LDRQREWDEAIRLFFYNEEKEL-----------------QLHVFEGPPPKPGELCEGEDT---RVY--HRRGAR--RWRKVRRINGHAFVAKRL-QAAYCAKCRERIWGL-GRQGYKCEACKMVVHKRCCYYLNKDEICAGHP--PAKQP---------------------------------------------------------------------------------------------------------------------------------------EESDKK-------PSDPF-NDFL-----------------------------------NINPV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SESQISLDDFDILKVIGRGSYAKVLMVELKQ-TKRIYAMKVIKKELVMDEEDIDWVQTEKHVFEQ-----ASNHPFLVGLHSCFQTESRLFFVIECVNGGDLMFHMQRHRRLPEEHARFYSAEIALALNFLHEKGIIYRDLKLDNVLLDQDGHIKLTDYGMCKEGLR-AGDTTSTFCGTPNYIAPEILRGQDYGFSVDWWALGVLLYEMLAGKSPFDV-GGHDMSDQSTEDYLFQVILEKTIRIPRTLSVKAAQVLKGFLNKSPGERLGCHLQ-TGFADITNHSFYKTIDWELLRCRQITPPYKPRIDSDRDPSNFDPQFVTEPIQFTPDDPETIGHIDQSEFAGFEYINPLLMSKIEEV- 'A.vastus_KPCE' ME----------------------LSFSGTLNIKIIKAEKLPAPNIA---R------IPT--LDPYVRIDVDELFFA------CTTVVS--KSVSAHWSEMFRES-VVDGEILGLTVFHSS---LIPPDPFVAHAALSLAELSTN------SGETREVVCDLEPSGKIHFEISFIPEDEAATIRRASRVF-------------------------IPNKIE---VRR-DHKRLAV--R-RKVHQINSHKFMAVYFKHFTYCAHCKDFMWGVVNKQGYQCQVCHMAVHKKCHSLVLT--PCNKAN--PDLLSP---------EEE-----NKDLRFSINVPHRFKSSSSKKPSFCDHCGSLIWGLTRQSRSCS--ACGITVHKRCEDHVPHSCGVDLKK----------------------------------------MSDMLTTLGKSGSRLSE----KDKPS-TLGRSKHLR-S-QVSTFESSNKERELMTASDKMVVTRTHTPPHHFDSYDSI--PIMRRPLPNSTPNSLKFTSTNHSSQGSKPDRPSRPSHSNSNDALLAEGG-NMARAHQDLHQKSLPVPLPRSKRN---------------LSKSAGNI-----------------------------REDSNADTPPRPPPPFANDSFPKHRIVASPKVPPPPLLPPKPQ-------QDPPPL---PPTPT-----RNP-----LLLKKSSLKDFTLLKLLGKGNFGKVLLAREVS-SETVVAIKIIRKDLTVANDDVVCAFIERNVLTK-----THLHPFLTKMYCSFQTEDRLFYVMEFVNGGDLLYHMQEKRKFGESMTKFYSAEIIEAILFLHSKEIIYRDLKLDNILLDSNGHVKLADFGMCKIGIS-GTKTADTFCGTPDYIAPEILKEEPYGKSVDFWSFGVLMYEMLTGQPPFE---------GNDEQELFNAILEEEVVIPPYISKEATNMVRGFLTKSQKRRLGCHPG-TGERSIRNHPFYSMITWSLLRKGEVRPPFIPKVANPEDCTNFDPEYLNENIAFTPCNSEMMNAMDENEFEGFSYTSPNITEIIKSP- 'A.vastus_KPC_A-B-G' MA------------------------------------------------------------------------------------------------------------------------------SKLVSSSSIDESEFE---------------------------------------------------------------------------------EMR--RKRVAF--REKKRLQIKNHIFECHFFKQPTYCAHCHQFIYGM-GKQGFQCLRCSYAMHKRCVDLIAF--RCPKFE--TVSERP---------DVK---------------HHEFKITNYTKFTFCDHCGQMLYGLYKQGYQCQAKVCGMNVHSYCREHVAKLCGTTSNEKYGQLMLNILCHVESEKKG--SLYVDIKNGKNLMAADPDGFSDPYCKLKLQDSKGKT----VVKHQ-TKIH---------------------------------KKTLNPTFDESFEI----------SFDPS-MD-------------------------GRLQIWMM-DWDNSIQSDNIGGMSFTIEELKTF-----NKGEDIWFALFNPAAATFMNQRSVSEADENER-DKIIQEY-------ESIREKNRTRFEK---------------------------------------------AKEKNR-----DSA-----SSLPILSIDDFERIELLGRGAFGKVIMVEYKRNPEKIYALKVMHKDLIFEYDAIDCTMIEQRILAL-----ESKPSFMTALRASFQDEENLYMVMEFLCGGDLLFHLIKCNSFTETRSRLYIAEISFGIYFLHQKGIVFRDLKPDNVLLDIEGHVKLADFGLCKEGIYHAKSNTSSFCGTLEYMAPEIVARKPYDTAVDIWSMGALLYEMLVGRPPFI---------GRTDDAIMESILTKSPVFPTFLNANAIQLISQMVKKNPNERVGVDAK-KGETDFRIHPYFSNFDWGKAERREMQPQFVPKLSNKRSDAYFDAEYTRCSTKITKLNPANILVIDQEMFTGFEFTSPEIVQ------ 'A.vastus_PKCD' MS-------------------------RSFIRIKLIEVKLPNSGN------------LFT--HEPFAAVSVKEKELKTDG-TAEYAQKK--KTFYPQWGRCFDSH-IHDGRRIHIIIMD-------GPENALLEVTVELLMLADHYRSD-MSGNAVKLALDLIPTGQLIMQVKVYGDKGDEDV--------------------FSESNPIPFTEDLPKNAT---ALR--GRRGAI--KLGNVNEVLCHQFFKKIFRQPAYCSLCHELMWGF-SKEGWQCKLCAYVAHRRCLDLILT--KCPKAT--NRSQ-----------ATM-----FLKERFKLDVPHRFTIHSYSSPNFCELCGQILWGLFRQGLQCE--VCGVNCHRRCKAAMPNLCGVNQKL----------------------------------------LAEALLDIKSQK---------ISKSK-DSST--------NTVMNVIKTGVVEE-----------RRANMPLPE--------------------------------------------------------------------------------------------------------------------------------------------PPTIN------------------------------------------------PVQV-----DSI-----VDVRKFLFTDFVLLKLLGKGSFGKVFLAQLKS-STEFFAIKALKKEVVLEDDDVECTLIEKRALSI-----ATNCPFLTHLHSTFQTKSHLFFVMEFLNGGDLMYHIQLSARFPESRTKFYSAEIVCGLQFLHDQSIVYRDLKLDNVLLDSYGHVKIADFGMCKENVS-LHKHTTTFCGTPDYIAPEIIQGKRYGISVDWWSFGVLCYEMLIGQSPFQ---------GEDEDDLFQSICNDSIDYPRWLSKEAINLVDKLLQRDPENRLGCIEE---IEPIKKHIFFADIHWVSLEKLEIVPPFKPKVRCSNDVGNFDADFTMEPPQLTPSEPKILEEMIQTEFDGFSYTNSKYLIK----- 'A.vastus_aPKC' MA----------SVVPRTEV----TSFLTQLPINLIYKG---------------KERKSN--LPTFQQMELVLPHIR----EAIGVHRD--MHINIKWIDDDGDP-----------------------------ITLE-------------------------SQLDWIELLRLFPYNQDGLL-----------------IMHVFDGPKPPPGHLCELEDI---NLY--KRRGAK--RWKKQLRLNGHIFQAKRL-NAAFCIICNDHIWGL-GRQGFRCTQCRIIVHKRCVKFIRQ--ICEGPS--QAAHSD--------------------------------------------------------------------------------------------------------------------------------RLPGSEAAESQR-------EERIK-KAIK---------------------------------QPASNPV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDSTISIDDFNILKVIGRGSYAKVLLAEQKK-RSKLYAIKVVKKELLTDEEDFDWVQTEKNVFEA-----ASNHPYLVGLHSCFQSESRLFFVIEFVRGGDLMFHMQRQRKLPEDHARFYSAEICLALNYLHEGGVIYRDLKLDNVLLDEDGHIKLTDYGMCKEKIF-KGETTNTFCGTPNYIAPEIIRGQSYSYSVDWWALGVLLYEMLVGRSPFDVTAHQHEAGDATEDLLFQMILEKTIRVPRSLSVRAANVLKGFLAKNPKDRLGCNPD-GGFLDIKSHQFFRSIDWKQLEMREVESPFIPRTEDERDVVNFDTQFTNEPLDFTPVDKGVLDRIDQAEFEGFEYVNPLFMTQEDQV- 'D.melanogaster_APKC' MQKMPSQILNDGSSVSLNSASMNMANTPNSITVKTAYNG---------------QIIITT--INKNISYEELCYEIR----NICRFPLD--QPFTIKWVDEENDP-----------------------------CTIS-------------------------TKMELDEAIRLYEMNFDSQL-----------------VIHVFPNVPQAPGLSCDGEDR---SIY---RRGAR--RWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGL-GRQGFKCIQCKLLVHKKCHKLVQK--HCTDQPEPLVKERA--------EESSDPIP--------VPLP--------------PLPYEAMSG--------------------------------------------------------------------------------GAEACET---------HDHAH-IVAP---------------------------------PPPEDPL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EP-----GTQRQYSLNDFELIRVIGRGSYAKVLMVELRR-TRRIYAMKVIKKALVTDDEDIDWVQTEKHVFET-----ASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIR-PGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRE-SAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSLEDCV- 'D.melanogaster_KPC3' MQ----------------------------------------------------------------------------------------------------------------------------------------------------SETAVQDLWVNLEPQGKIHVIIELKNRTDKAKAEA-------------------VVEHTVAVNKEFKERA----GFN--RRRGAM--R-RRVHQVNGHKFMATFLRQPTFCSHCREFIWGI-GKQGYQCQVCTLVVHKKCHLSVVS--KCPGMR--DEQPAKV--------EMV-----PAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCE--TCGMNVHKRCQKNVANTCGINTKQ----------------------------------------MAEILSSLGISPDKQQ-----PRRSK-YLNQQGG-----EDNYGASLGADGD------------GAPGQSFRSC--------------ALSVDSLA-------------------------TSTTTMTS-GYNSSSC---------------------------------------------------------------------MSLAVTGSGGVGA--------------------------------------------------------TGE-----TRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKG-TDEIYAIKVLKKDAIIQDDDVDCTMTEKRILAL-----AANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIM-NGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFE---------ADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGD---ENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNPKFGPER---- 'D.rerio_PKCB' MA--------------------------------------------------------------------------------------------------------------------------------------------------------------EPAN--------------------------------------------------SDGEERSAPMRGF--ARQGAL--RQKNVHEVKNHKFIARFFKQPTFCSHCTDFIWGF-GKQGFQCQVCCFVVHKRCHEFVTF--SCPGAD--KGPASD-----------------------DPRSKHKFKVHTYSSPTFCDHCGSLLYGLIHQGMRCD--HCMMNIHKRCVANVPSLCGTDHTERRGRIQITAEIKNN-------VLTVSIKEAKNLVPMDPNGLSDPYVKLKLIPDPKS-----ESKQK-TKTI---------------------------------KCCLNPTWNETFTF----------NLKESDKD-------------------------RRLSVEIW-DWDLTSRNDFMGSLSFGISELQK-------QGVDGWFKLLSQEEGEYFNVPVPPEGEEGNE--ELRQKF----------ERAKIGPSKT---DGSSSNA-------------------------------------ISKF-----DSN-----GNRDRMKLSDFNFLMVLGKGSFGKVMLAERKG-ADELFAIKILKKDVVIQDDDVECTMVEKRVLAL-----SGKPPFLTQLHSCFQTMDRLYFVMEYINGGDLMYHIQQVGKFKEPHAVFYAAEIAIGLFFLHSKGVIYRDLKLDNVMLDAEGHIKIADFGMCKENML-DGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQPPFD---------GEDEDELFQSIMEHHVSYPKSMSKEAVAICKGLMTKHPGKRLGCGP--EGERDIREHGFFRYMDWEKLEHREVQPPFKPKA-CGRDAENFDRFFTRHPPVLTPPDQEVIMNLDQDEFEGFSFINPEFPAM----- 'D.rerio_PKCD' MA--------------------------PFLRIAFNAYDLGTFSPMA-EA--------------PFCAVKMKEALSTERG--KTLVQKK--PTMYPAWRSSFDAH-IFEGRVIQILLMRTA-------EEPLADVTVGVSVLAERCKKA---NGHAEFWVDLQPSGKVMMSVQFFLEDSDTGS---------------------VCRHSVVANE----EIP---TLN--RRRGAI--KQAKIHFIKNHEFIATFFRQPTFCSVCRDFVWGL-NKQGYKCRQCNAAIHKKCIDKIIG--RCTGTA--ANSR-----------DTM-----FQKERFKIDMPHRFKTNNYMSPTFCDHCGSLLWGLVKQGLKCE--DCSMNVHHKCQTKVANLCGINQKL----------------------------------------LAEALTQVSTKS---------STKRPDNNTQ---------------------------------------------------------------------------------------------DVGVYQDFNKSP-----------------------------------------------------------------------------GPDVTD---GT-PYGH--------------------------IWE-----GSSPRPP-----SRI-----THQTRITAEHFIFHKVLGKGSFGKVLLAELKG-TGEWFAVKALKKDVVLMDDDVECTMVEKRVLAL-----AWDNPFLTHLYSTFQTKEHLFFVMEYLNGGDLMFHIQEKGRFDLYRATFYAAEIVCGLQFLHSKGIIYRDLKLDNVMLDGDGHIKIADFGMCKENVF-GDNRATTFCGTPDYIAPEILLGQQYSFSVDWWSFGVLVYEMLIGQSPFH---------GDDEDELFESIRMDTPHYPRWILLDTRDMLERLFERDPSRRLGIVG------NIRGHSFFKTVNWAALEGREVDPPFKPKVKAPNDCSNFDREFLSEKPRLSHCEKGLIDSMDQCAFAGFSFINPKMEHLITK-- 'D.rerio_aPKC-iota' MPTL-----RD-STMSHP------GENPHQVRVKAYYRG---------------DIMITH--FEPSISYEGLCNEVR----DMCSMDND--QLFTMKWIDEEGDP-----------------------------CTVS-------------------------SQLELEEALRLYELNKDSEL-----------------IIHVFPCVPEKPGMPCPGEDK---SIY---RRGAR--RWRKLYYATGHAFQAKRFNRRAHCAICTDRIWGL-GRQGYKCINCKLLVHKKCHKLVTV--ECGRQV------------------IQDPMIGRIDPG--STHP--------------EHPDQVL-----------------------------------------------------------------------------------GKKNST----------ESIN-HEGE---------------------------------E---HEA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGSR-----ESG-----KAVSSLGLIDFDLLRVIGRGSYAKVLLVRLKK-TERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ-----ASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLR-PGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKGFLNKESKERLGCHPQ-TGFADIMAHPFFRNVDWDLMEQKQVVPPFKPNISGEFGLDNFDAQFTNEPIQLTPDDDDAVKKIDQSEFEGFEYINPLLMSAEECV- 'D.rerio_aPKC-lambda' --------------MSHP------GENPHQVRVKAYYRG---------------DIMITH--FEPSISYEGLCNEVR----DMCSMDND--QLFTMKWIDEEGDP-----------------------------CTVS-------------------------SQLELEEALRLYELNKDSEL-----------------IIHVFPCVPEKPGMPCPGEDK---SIY---RRGAR--RWRKLYYATGHAFQAKRFNRRAHCAICTDRIWGL-GRQGYKCINCKLLVHKKCHKLVTV--ECGRQV------------------IQDPMIGRIDPG--STHP--------------EHPDQVL-----------------------------------------------------------------------------------GKKNST----------ESIN-HEGE---------------------------------E---HEA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGSR-----ESG-----KAVSSLGLIDFDLLRVIGRGSYAKVLLVRLKK-TERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ-----ASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLR-PGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKGFLNKESKERLGCHPQ-TGFADIMAHPFFRNVDWDLMEQKQVVPPFKPNISGEFGLDNFDAQFTNEPIQLTPDDDDAVKKIDQSEFEGFEYINPLLMSAEECV- 'D.rerio_aPKC-zeta' MPVS------NGSMMDLP---------SEYVKIKAHYGG---------------DMLISD--LDLALTYTEVCKEVR----EMCGVRKE--TPITLKWIDDEGDP-----------------------------CTIS-------------------------SQMELEEAFRIYSRSRHSGL-----------------LLHVFPSIPEKPGMPCPGEDK---SIY---RRGAR--RWRKLYRVNGHLFQAKRFNRKAYCGHCSERIWGL-GRQGYKCINCKLLVHKRCHKLVPL--TCQRHM-----DPV--------MPSQEPLVDDDKSGEEVELPPE-----------DPEDTDAI---------------------------------------------------------------------------------PVPFLAHNRK-------VEKAE-DDSE---------------------------------D--LKAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VDGI-----EGI-----QISQCLGLGDFDLIRVIGRGSYAKVLLVRLKK-NEQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ-----ASTNPFLVGLHSCFQTESRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHEKGIIYRDLKLDNVLLDQDGHIKLTDYGMCKEGIR-PGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEEYLFQVILEKPIRIPRSLSVKAASVLKGFLNKDPKERLGCQVQ-TGFTDIKSHTFFRSIDWDQLEQKQVTPPFKPQITDDYGLENFDTQFTNEPVQLTPDDEDVIKRIDQSEFEGFEYINPLLLSTEETV- 'G.cydonium_KPC_A-B-G' MA----------------------------------------------------------------------------DGG-----------------------------------------------------------------------------SLDVEP--------------------------------------------------------------RRPVRRNAV--RQARVVEVKGHKFVLTYFKTFTFCGHCGRFLWGVTGPQGYQCKLCDFVMHKRCLDYVSF--ICPDVH--IGNGA--------------------------PSPRKFKTTSFRHPTWCDHCGSFIYGLMNQGKTCG--DCGVNVHHRCHEMVPKTCGQQVKETRGRLEMSVRSEDIDDDHI--RLHIGIIQGANLPPMDANGYADPYVKLRLLPEASN-----AAKQK-TERQ---------------------------------TKTLSPVWEETFFF----------DVNKADTS----------------------FELSRLVIEVW-DWDRYTANDLIGGFSIPVPEIVE--WSKGGATVCNWYRLLDSKSLKQKYEHVIDTVKL-----RTDRGVQ------EEDEDRQGAGTPE---GIP--DL----------------------------------RRGSEMV-----PES-----HGLPKMSLGEFKLIVVLGKGSFGKVFLAEHKE-SKEVYAIKSLKKDLIVQEDDVECTLNERKVLAL-----QSKPPFLINLHSCFQTEEHLFFVMEYVSGGDLMFHILELGRFSESQTRFYAAEIVLGLVYLHNLGIIYRDLKLDNVLLDSEGHVKIADFGLCKDGIS-GTSKARTFCGTPDYIAPEIIQYHPYDAAVDWWALGVLIYEMLVGRPPFD---------GDDDDQLFMNIVQKQVHYPRGLSEPCRKIISGLLTKNASKRLGSHPE-AGVDMIKAQPFFKNMDWEKLARREVKPPYRPKNKGKKNRDNFDPEFTKEPCRLSPVDSNIIAAIDPGAFEGFSFTNPELFIEP---- 'L.complicata_KPCE' MA-----------------------NYTGTLVVTVLSAEDLPQST-----AAPGGRLLTS--IDPYCAVSVDGNYVG------QTDHVR--DTCSPQWNQTTDEAFVQNAVMVDVSVFHHA---SPPPDVFICNATIGLEELLKC---------SGVVELTLDPRGRIQVEATFKEGAPSGG---------------------------QRTGKAFQERD----VVQ--KRRGAL--R-RVIHQANGHKFVARFFGQFTYCAHCKEFLWGF-GKQGYQCQICTIVLHKKCHALVLT--PCPGND--AASDS------------------HSLTGFSINIPHVFEEHSYLSPTFCDHCGSLLYGLFKQGLKCK--SCKFNSHKRCAHNVPRNCGIKTKE----------------------------------------MAGILAAMGQSAEKLNEKTS-DSTQK-ATKAHSM-----HSRRNNAT-----------------KDPLQPEQQS----------------------------------------------------------------------------------------------------------------------------------------LMPSPSLPP---------------------------------------------AVSAPM-----SPN-----SAKNRVNMQDFNFIKVLGKGSFGKVMLAEKRG-TEEVYAVKVLKKDIILQDDDVECTLTEKRVLAL-----AGRHPYLTSLHSCFQTQASLFFVMEYVNGGDLMFQIQKARKFDEPRARFYSAEIVSALLFLHANGVIYRDLKLDNVLLDSDGHVKVADFGMCKEGIT-GNSLTNTFCGTPDYIAPEILQELDYGASVDWWALGVLMYEMMAGQPPFE---------AESEEELFDVILNDEVLYPLWLSREAASILRGFLTKNPARRLGCTT--TGERAIKAHPFFKPVDWTSLEAREVQPPFRPNIKSKKDVGNFDTDFTSEEAVVTPPEKGVVETLNQEEFFGFSYVNPEFAGNC---- 'L.complicata_KPC_A-B-G' MS-------------------------------------------------------------------------------RASAASAG-------------------------------------------------------------------------------------------------------------------SSNGSVQYREEIPEGTA---FAR--GRRGAL--KKKNVVTVNDHEFEPRFFKQPTYCAHCKEFIWGF-GRQGFSCRICQFAVHRRCHEFVSF--TCPGAE--KEDE-------------------------GANSPHRFKVCSYSQPTFCDHCGSMLYGLVKQGLKCE--ACEMNVHKRCQKLVPQLCGCDHTEKRGRLCLWFKVTNQTPMLK--VLTVGIREAKNLPPMDANGLADPYVKVWFTDDASK-----SSKQK-TSTK---------------------------------MKTLNPTWKESFDF----------NITSSDVS-------------------------RSLTMEVW-DWDRTTRNDFIGKMTFKIEEICKFQPTTDDGFYEGWFKLLNESEGSAYNVPIVEGPLDGRR---------------ASGRSGSMSPTGA---DDKALSSAMSGA-----------------------------DLST--------VGE-----IAGRKPKLSDFQMLKVLGKGSFGKVMLAQLKG-KDQYYAIKVLKKDVIVQDDDVECTMIEKRVLAL-----QEKPPFLTALHSTFQTKDRLFFVMEFVTGGDLMYHIQQHGKFKEPTAAFYSGEIVIGLSFLHRRGVIYRDLKLDNVMLDGEGHIKIADFGMCKEGIY-DQVLTRTFCGTPDYIAPEIVAYQAYNGSVDWWALGVLIYEMLAGQPPFD---------GDDEDELFSNIMGEEVRFPKSMSKEACSICKAFLAKHPARRLGCGP--NGELDIQDHSFFRSINWEKLRNREIAPPFRPKQGKKGAATNFDKDFTEEPAKLTPCDRNVIDGIKEDIFAGFSFMNSDLM------- 'L.complicata_PKCD-1' ME---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNHEA-VHKDLT---MLT--GRRGAI--RHKKCHVVNGHKYKARFFRQPTFCAFCREFLWGF-GKQGYQCETCAQVVHKKCHEQVLG--KCPGRK--GDASAGLADRRDRDNKSS-----EELNRFNIDVPHRFRVHNYLHPTFCDHCGSMLYGLFRQGYKCE--TCGSNCHKRCRELMPNLCGVNEKL----------------------------------------MAEALTLVKKDREQGGRVGK-VNRQT-SAPEKNG-----GLPN---SA----------------QPSTRGVSSAGG------------NSLANR-------------------------------------------------------------------------------------------------------------------------SLSA----------------------------------------------NPNIT------SS-----YRGKKFTLSDFNMLKVLGKGSFGKVLLAELKA-KRQYFAVKVLKKDVVLEDDDVECTLTEKRVLAL-----SCQHPFLTHLHSCFQTEAHLFFVMEFINGGDLMYHIQQAGRFDEDRTRFYVAEITCGLQFLHSKGVIYRDLKLDNVMLDCDGHIKITDFGMCKEDVF-GSRTTSTFCGTPDYIAPEIIDGSKYGFSVDWWSLGVLCYEMLLGQSPFS---------GEDEDDLFDSILHDDVVYPRWLPKEAATFISRLLVRDPTCRLGCRE----DLDIRKDIFFRTIEWEKMERRQMSPPFKPSVQSAFDANNFDVDFTMEPAVVTPVDKELVMSIDQDQFHGFSFVSSDFGQLK---- 'L.complicata_PKCD-2' MA----------------------EAPNAFLRLKILQVTKLRENT-----------------NDPQLAVNIKEAVPGPGGKDVQIVQKK--KTFCPEWGKCFDSH-LSDGRRMQVLVKDRAPGGSAEDGVTVGELTVLLASIAEQCQLG--GSGVSKMSLDLKPAGELTIQAKVYKSETETAEQPAAAAAASLSAELASVGIESAQCMEDQPEE-LHKNIT---MLR--NRRGAI--RHANLHEVNGHRYRARFFRQFTFCAFCKEFLWGF-GKQGYQCQECDQVVHKKCHLLVLA--KCPGAK--DGAEHR-------TNLAS-----DLQARFNIDMPHRFKVHNYLHPTFCDHCGTLLYGLFRQGLKCE--TCGTNCHKRCKQHVPNLCGINEKV----------------------------------------MSEALVNVNKDREA---------KKG-SPATKKK-----DRGD---KP----------------SP-SRLTSQASK-----------------------------------------------------------------------------------------------------------------------------------------AGGVDE----------------------------------------------GMSRL------AV-----SSKPKFKLEDFNMLKVLGKGSFGKVMLAQVKS-TKQYLAVKVLKKDVVLEDDDVECTMIEKRVLAS-----TSKHPFLTHLHSAFQTEGHLYFVMEYINGGDLMFHIQQQGRFNEDRTRFYVAEIVCGLQYLHSCGIIYRDLKLDNVMLSSAGHIKIADFGMCKENIS-GNSTTGTFCGTPDYIAPEIIDSLQYNSSVDWWALGVLAYEMLLGQSPFS---------GEDEEGLFHSIANDEVVYPVWLSKESRSFVSKLLIRDPATRLGC-----GSADIRREPFFKPIDWQKLENCEITPPFVPTVKSAGDAGNFDVDFTMEPAIITPTDEKLLRSMDQEPFNGFSFVNDCFPSH----- 'L.complicata_aPKC' MA------------------------LEGYVTVQVIFNS---------------KEHMMG--MNPSTSLDEFLRDVR----TLCRLDKE--KSMTVKWVDEEGDP-----------------------------CTIE-------------------------SQPELEEVIRLYFAHNVIEV-----------------NVFVFDSTPAQPGLACEGEHR---VAY--GRRGAR--RWKKLHRVNGHAFAAKRT-YTLVCAVCNDRIWGL-GRQGYKCMNCKLVVHKKCYKFVHK--ICSGHP--PTAHGD--------KSDSD----------------------------------------------------------------------------------------------------------------------SGEEAGGKD-------QPKPR-RMKE----------------------------------SSGSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNNSVISLDDFEILRVIGRGSYAKVILVELKE-TNRLYAMKTIKKELITDDEDIDWVQTEKHVFEQ-----SSNHPFLVGLHSCFQTASRLFFVIEYVNGGDLMFHMQRQRRLPEDHARFYSAEISLALNYLHEKGIIYRDLKLDNVLLDSDGHVKLTDYGMCKEGLR-PGDTTSTFCGTPNYIAPEILRGEEYDWSVDWWALGVLMFEMLAGRSPFDVVSGNEHGDQSTEDYLFQVILEKTIRIPRNISVRAGNVLKAFLEKNPKERLGCNPQ-TGFSDIMNHVFFRTVDWELMENRQFPPPYAPPLKDERDLTNFDPQFTTEPLDFTPDDPKVLSAIDQSEFEGFEYVNPLLMSKADDV- 'M.leidyi_KPC_A-B-G' MA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDDGVGGKQF--VRRGAV--KRGKVHEVRDHKFQARFLNQPTYCAHCKDFIWGVFGKQGYQCTICSFVVHKRCHELVSF--ACPGSD--KVDCE-------------------------TTQPHTFKVKTYSSPAFCDQCGSLLYGLFNQGLECT--ACEMKVHHHCEKNTPMLCGIDHTEKRGRMELEITIEKDSSDKDEWTLHIKIKQGRNLIPMDANGFSDPYVKIKLIPDPDQ-----IYKQK-TNVI---------------------------------KKTLDPVWNEKFNI----------HGVSVVND-------------------------KRILLEVW-DWDRASRNDFMGCMSFSIKDDVV------GGGVCGWYKLLPELEGQAYNIPCVVEDKMQ----AIQDEM----------SKVNLDNTGF--------------------------------------------------------EQR-----VSQSKYTKDSFTFLKVLGKGSFGKVMLAELKG-KDEVYAIKILKKDVIVQDDDVECTMTEKRVLAM-----GNRPPFCAFLHSCFQTPDRLYFVMEYINGGDLMYQIQQVGKFKETQACFYAAEIVVGLLYLHKNGVVYRDLKLDNVMLDCDGHIKITDFGMCKDEMF-DGRTTRTFCGTPDYIAPEIIAYNPYSFSVDWWALGVLLYEMLCGIPPFD---------GEDEDSLFACIVESSVSYPKSLSKDANSIIQGFLTRNPETRLGCGP--SGESDIRNHAFFRQIDWRALENREVKPPFKPRIKNKKSTNNFDSEFTHEKVALTPCDANFIKKINQSEFAGFSYFNEEEFLRRKK-- 'M.leidyi_aPKC' MD-------------SLNSN----SIPVRSVPIKAGYVN------------LYRDQKRTS--IEPHISYEDLLQQLI----NLLQLDRSITEDYTVKWIDEEGDP-----------------------------CTIA-------------------------SKKELDEAIRLFILSQEKEL-----------------QIHVFPGIP-KPGDFCAGEST---KFY--ERKGAR--RWKKNYRVMGHSFAPRRFSFKVECPICRDSIWGI-GRQGFKCINCKTLLHKRCCRYITE--PCPGYP--LDHQHV-------------------------------------------------------------------------------------------------------------------------------------ISPTPDR-------LNNIK-HDFS---------------------------------VPDPGPI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPPGGITLDDFDLMAVIGRGSYAKVLMVKLKS-TQKTYAMKIIKKSIIDDEDDIEWVQTEKNVFEQ-----ASNHPFLVGLHSCFQTTSRIVFVIEFVNGGDMMFHMQKLQRLEEDHARFYAAEISCALHYLHDHLIIYRDLKLDNVLIDSEGHIKLTDYGMCKECSV-DDQTTGTFCGTPNYIAPEVLKGGQYSYSVDWWALGVLLYEMLCGRSPFNVDNQPTDNPEESENLLFQCILTKPVRIPRALSVKAGSVLKYLLRRDPEERLGCNKE-QGFNQIKQHPFFNVLDWDLLESRQVTPPYIPPIAAEDDLANFDRAFTDEAVQLTPDDPDELARINQSEFEGFEYINPLLLNKEEAV- 'M.musculus_KPCA' MA--------------------------------------------------------------------------------------------------------------------------------------------------------------DVYPAN----------------------------------------------DSTASQDVA---NRF--ARKGAL--RQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF-GKQGFQCQVCCFVVHKRCHEFVTF--SCPGAD--KGPDTD-----------------------DPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCD--TCDMNVHKQCVINDPSLCGMDHTEKRGRIYLKAEVTDE-------KLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKN-----ESKQK-TKTI---------------------------------RSNLNPQWNESFTF----------KLKPSDKD-------------------------RRLSVEIW-DWDRTTRNDFMGSLSFGVSELMK-------MPASGWYKAHNQEEGEYYNVPIPEGDEEGNM--ELRQKF----------EKAKLGPVGN---KVISPSE--------------------------------------DRK-----QPS-----NNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG-TEELYAIKILKKDVVIQDDDVECTMVEKRVLAL-----LDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLNNVMLNSEGHIKIADFGMCKEHMM-DGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFD---------GEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKQPAKRLGCGP--EGERDVREHAFFRRIDWEKLENREIQPPFKPKV-CGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHP----- 'M.musculus_KPCB' MA--------------------------------------------------------------------------------------------------------------------------------------------------------------DPAAGP----------------------------------------------PPSEGEEST---VRF--ARKGAL--RQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF-GKQGFQCQVCCFVVHKRCHEFVTF--SCPGAD--KGPASD-----------------------DPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCD--TCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRE-------VLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKS-----ESKQK-TKTI---------------------------------KCSLNPEWNETFRF----------QLKESDKD-------------------------RRLSVEIW-DWDLTSRNDFMGSLSFGISELQK-------AGVDGWFKLLSQEEGEYFNVPVPPEGSEGNE--ELRQKF----------ERAKIGQGTKAP-EEKTANT-------------------------------------ISKF-----DNN-----GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKG-TDELYAVKILKKDVVIQDDDVECTMVEKRVLAL-----PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW-DGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFE---------GEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGP--EGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNPEFVINV---- 'M.musculus_KPCE' MV-----------------------VFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFL--LDPYIALNVDDSRIG------QTATKQ--KTNSPAWHDEFVTD-VCNGRKIELAVFHDA---PIGYDDFVANCTIQFEELLQN------GSRHFEDWIDLEPEGKVYVIIDLSGSSGEAPK--------------------------DNEERVFRERM----RPR--KRQGAV--R-RRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIIT--KCAGLK--KQET-----------PDE-----VGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCK--VCKMNVHRRCETNVAPNCGVDARG----------------------------------------IAKVLADLGVTPDKITNSGQ-RRKKL-AAGAESP-----QPASGNSPSEDD-------------RSKSAPTSPC--------------DQELKELE-------------------------NNIRKALS-FDNRGEE---------------------------------------------------------------------HRASSATDGQLAS--------------------------------------------PGENGEV------RP-----GQAKRLGLDEFNFIKVLGKGSFGKVMLAELKG-KDEVYAVKVLKKDVILQDDDVDCTMTEKRILAL-----ARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGIM-NGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFE---------ADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPILTLVDEAIIKQINQEEFKGFSYFGEDLMP------ 'M.musculus_KPCG' MA--------------------------------------------------------------------------------------------------------------------------------------------------------------GLGPGG--------------------------------------------------GDSEGGPRPLF--CRKGAL--RQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGI-GKQGLQCQVCSFVVHRRCHEFVTF--ECPGAG--KGPQTD-----------------------DPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCS--CCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRA----PTSD--EIHITVGEARNLIPMDPNGLSDPYVKLKLIPDPRN-----LTKQK-TKTV---------------------------------KATLNPVWNETFVF----------NLKPGDVE-------------------------RRLSVEVW-DWDRTSRNDFMGAMSFGVSELLK-------APVDGWYKLLNQEEGEYYNVPVADADNC-----SLLQKFEACNYPLELYERVRMGPSSS---PIPSPSP--------------------------------------SPT-----DSKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRG-SDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVF-PGSTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFD---------GEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGP--DGEPTIRAHGFFRWIDWERLERLEIAPPFRPRP-CGRSGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVHPDAR-- 'M.musculus_KPCI-iota' MPTQ-----RDSSTMSHTVACGGGGDHSHQVRVKAYYRG---------------DIMITH--FEPSISFEGLCSEVR----DMCSFDNE--QPFTMKWIDEEGDP-----------------------------CTVS-------------------------SQLELEEAFRLYELNKDSEL-----------------LIHVFPCVPERPGMPCPGEDK---SIY---RRGAR--RWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGL-GRQGYKCINCKLLVHKKCHKLVTI--ECGRHS------------------LPPEPMMPMDQ---TMHP--------------DHTQTVI-----------------------------------------------------------------------------------PYNPSS---------HESLD-QVGE---------------------------------E---KEA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNTR-----ESG-----KASSSLGLQDFDLLRVIGRGSYAKVLLVRLKK-TDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ-----ASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLR-PGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQ-TGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV- 'M.musculus_PKCD' MA--------------------------PFLRISFNSYELGSLQVED-EA------------SQPFCAVKMKEALSTERG--KTLVQKK--PTMYPEWKTTFDAH-IYEGRVIQIVLMRAA-------EDPVSEVTVGVSVLAERCKKN---NGKAEFWLDLQPQAKVLMCVQYFLEDGD-------------------------CKQSMRSEE----EAK--FPTM--NRRGAI--KQAKIHYIKNHEFIATFFGQPTFCSVCKEFVWGL-NKQGYKCRQCNAAIHKKCIDKIIG--RCTGTA--TNSR-----------DTI-----FQKERFNIDMPHRFKVYNYMSPTFCDHCGSLLWGLVKQGLKCE--DCGMNVHHKCREKVANLCGINQKL----------------------------------------LAEALNQVTQRS---------SRKL--DTTE---------------------------------------------------------------------------------------------SVGIYQGFEKKP--------------------------------------------------------------------------EVSGSDILD---NNGTYGK--------------------------IW--------------------------EGSTRCTLENFTFQKVLGKGSFGKVLLAELKG-KDKYFAIKCLKKDVVLIDDDVECTMVEKRVLAL-----AWESPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENIF-GEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLIGQSPFH---------GDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLGVTG------NIRIHPFFKTINWSLLEKRKVEPPFKPKVKSPSDYSNFDPEFLNEKPQLSFSDKNLIDSMDQEAFHGFSFVNPKFEQFLDI-- 'M.musculus_aPKC-lambda' --------------MSHTVACGGGGDHSHQVRVKAYYRG---------------DIMITH--FEPSISFEGLCSEVR----DMCSFDNE--QPFTMKWIDEEGDP-----------------------------CTVS-------------------------SQLELEEAFRLYELNKDSEL-----------------LIHVFPCVPERPGMPCPGEDK---SIY---RRGAR--RWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGL-GRQGYKCINCKLLVHKKCHKLVTI--ECGRHS------------------LPPEPMMPMDQ---TMHP--------------DHTQTVI-----------------------------------------------------------------------------------PYNPSS---------HESLD-QVGE---------------------------------E---KEA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNTR-----ESG-----KASSSLGLQDFDLLRVIGRGSYAKVLLVRLKK-TDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ-----ASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLR-PGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQ-TGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV- 'M.musculus_aPKC-zeta' M--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSV--------MPSQEPPVDDKNDG--VDLP--------------SEETDGI-----------------------------------------------------------------------------------AYISSSRK-------HDNIK-DDSE---------------------------------D--LKPV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IDGV-----DGI-----KISQGLGLQDFDLIRVIGRGSYAKVLLVRLKK-NDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ-----ASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLG-PGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQ-TGFSDIKSHAFFRSIDWDLLEKKQTLPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDVIKRIDQSEFEGFEYINPLLLSAEESV- 'N.vectensis_KPCE' MV-----------------------GFTGSLKLRIFEAIELKPAA-----KAHWGVKLTT--IDPYLLVKVDDVQIA------QTTSKT--KTFTPVWNEEFIVE-VENGRDLEFAVFHNA---IMPPKPFIANTTVSLEEVIKS--------GSSEIWIPLEPHGQVHVNIELKPSNTAHQHYH------------------------DKEQRVFKENPG---GIN--RRRGAM--R-RRIHQINSHKFMATYLRQPTFCSHCNDFIWGVIGKQGYQCQVCTCVVHKRCHKMVVT--KCPGTR--QDAETM---------PLG-----GGSLRFKMDVPHKFEKKSYNRPTFCELCGSLLYGIVRQGMQCT--VCKMNVHRRCHQNVANNCGINPKK----------------------------------------MAEILEEIGISPDRIHEESQ-QIKKP-SFHDCTN-----KPAKKMTP-----------------RSVSSPSMME----------------------------------------------------------------------------------------------------------------------------------------SVNENGLPGSTFKLESH------------------------------------QTSPGER------RR-----HVLRKMTLKDFTFIKVLGKGSFGKVLLAERKG-TDEVYAIKILKKESVLQDDDVECTMIERRVLAL-----SAGHPFLTSLHSSFQTVERLFFVMEYVNGGDLMFQIQKSRKFDENRSRFYAAEVVLALQFLHQNGVIYRDLKLDNVLLDADGHIKLADFGMCKENMA-PGKTTTTFCGTPDYIAPEILQEQPYGFSVDWWALGVLMYEMMAGQPPFE---------AENEEDLFESILHDDVLYPVWLSREAVSILKGFMTKNYLKRLGCTPT-STESSIREHAFFRLINFEKLEARQINPPFKPKIRSRTDVGNFDTDFTKEEPKLTPTDRNVIVNIDQREFRGFSFVNPHFV------- 'N.vectensis_PKCD' --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPHNFGPHTYKSPCFCDHCGSLLYGVYHQGLKCT--ACDMNVHKKCEKAVPKLCGADHTERRGRIHLK--------------ISYELREARNLMPMDPNGLSDPYVKVKLLPDPDN-----TSKKK-TKIF---------------------------------KESLSPVFNETFEF----------KIQNKDKD-------------------------RRLSIEVW-DWDRTTRNDFMGSLSFGVSELQK-------NGVEGWFKLLSQEEGEYYNIPIDDAREEEER--KCRQKL----------EQSL---------------------------------------------------------------SD-----PNAKKFRPEDFHFLKVLGKGSFGKVMLAERKG-TDQVYAIKVLKKDVIVQDDDVECTMTEKRVLAV-----PGKPPFLTQLFCCFHSVDRLYFVMEFVNGGDLMFHIQQAGRFKEPQAVFYAAEIVIGLVFLHKRGIVYRDLKLDNVMLDSDGHIKIADFGMCKESMF-NNQTTRTFCGTPDYIAPEIVAYQPYGFSVDWWALGVLIYEMLAGQV--------------------------------------------------------------------------------------------------------------------------------------------------- 'N.vectensis_aPKC' MM-----------------------NSTSAIAVRAAYNG---------------DIMCLS--MDPHISLDTFTEDMK----DIFKFRKE--QTFTLKWLDEEGDP-----------------------------CTIS-------------------------SQEELNEAIRLYEINRDSEL-----------------VVHLFLGEPQYPGQLCNGETR---NIY---RRGAK--RWRKIHIVNGHSFVAKRFSRLAACAFCSDRIWGL-GRSGYKCLECKLVVHKKCHKLIKI--QCGQQL--MTQGNA--------MHSSLP----------------------------------------------------------------------------------------------------------------------PIGAIGTKL------------PTNE-----------------------------------DLGPK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RKPGS-----GAGALISVNDFNLIRVIGRGSYAKVMLVELKK-TKRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ-----ASNHPFLVGLHSCFQTSSRLFFVIEYVSGGDLMYHMQRQRRLPEDHARFYSAEICCALNFLHEKGVIYRDLKLDNVLLDSDGHIKLTDYGMCKEGIR-PGDVTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDIVGSADNPDQNTEDYLFQVILEKPIRIPRSLSVKAASILKGYLNKNPTERLGCHPQ-TGFADITSHAFFRTVSWEQLEARQVTPPFKPRQEDPYGLENFDPQFTNEDVQFTPDDPKMLETIDQTEFEGFEYINPLLMSVEDSV- 'O.carmela_KPCE' MA---------------------RKTYTGTLTVKVLEASTLKPPT------IPGGIVLTT--IDPYVRVSYDDIFLN------ETKSKD--KTTNPLWNDEFDGD-LYRGENFQITIFHKS---LVGPEPFVANVSVPFEEILQG-----EKGQLLDYWLSLEPAGKIHVAVAFVDRSSGTM------------------------------GRVFKQNTQ-GWGIK--GRQGAL--R-RKIHAVNGHKFMATYLRQLTYCSHCSEFIWGLVGKQGYQCQVCLAVVHKRCHQLVVS--TCTGQE--VARTEE---------EYV-----AAGHRFSLNMPHQFEDHNYKIFTFCDHCGSLLWGLVRQGLKCK--SCKLNVHKRCRTKVANNCGVNPKM----------------------------------------LAATLADLGQSADRLTQSSM-KSRKS-ITSQGSG-----E------SSSTM-------------PIRSAPSGNH----------------------------------------------------------------------------------------------------------------------------------------LAAPTRPPP---------------------------------------------SRPAPS------RP-----KSSGRVTVNDFAFLKVLGKGSFGKVLLAEHKA-SKEVFAVKVLKKTVIARDDDIECTLTEKRVLAL-----ACEHPFLTALHSCFQTKDCLYFVMEYVNGGDLMFQIQRARKFDEARSRFYSAEIVSALSFLHSRGIIYRDLKLDNVLLDSEGHVKVADFGMCKEDII-DDCTTNTFCGTPDYIAPEILQEQNYGASVDWWALGVLMYEMMAGQPPFE---------ADNEEDLFDSIIHDDVLYPVWLSKEAASIIRGFLTKMPNKRLGCQAG-VGEQVIRSHPFFRSIDWIALEARQVKPPFKPKVADKRDVTNFDKDFTQEKAVVTPTSKQDMEIVNQDDFSSFSFVNEKFH------- 'O.carmela_KPC_A-B-G' MA-------------------------------------------------------------------------------TSRSARGS---------------------------------------------------------------------------QGDI-------------------------------------------HSDTLPTEG----GFQ--RRRGAI--RQKRVHSVKSHKFVARFLKQPTFCAHCKDFIWGLLSRQGFQCQVCSFVVHKRCHEFVSF--QCPGVD--SGPDSD-----------------------APQSSHLFKVHSYGSPTFCDHCGSLLYGLFNQGLQCD--ACRMNIHKRCERLVPKLCGKDHTERRGRLYLAIQYIPTSAILG--KLHVEIREGKNLPPMDPNGLSDPYVKLRIMPDPEK-----STKKK-TAIK---------------------------------KGTLNPVYNESFDF----------PVSSAKQD-------------------------HCLAVEVW-DWDRATRNDFIGSMSFPLKEFMA------GNSVSGWYKLLEESKGTHYNEPCPEEDNTLSE--RLEEE--------GTLNDVPRSPSVQ---QFQSLSSTSTSK-----------------------------SQSRQPD-----TSGLV---DSSRKFGLKDFQFMVVLGKGSFGKVMLAELKG-QDKYYAIKVLKKDVVVQDDDLECTLIEKRVLSL-----QGKPPFLTALHSTFQTEGRLFFVMEYVNGGDLMFHIQKIGRFPEPQASFYAAEIVIGLLYLHDKGIIYRDLKLDNIMLDHEGHVKIADFGMCKENIL-QGKTTRTFCGTPDYIAPEIIAYQPYGSSVDWWALGVLLYEMLIGQPPFN---------GRDEDELFDHILQKNPNFPRWLSKEAVAICKGFLAKHPARRLGCSS--TGEKDLKSHQFFRKFDWDKLERREIQPPFKPKIKSKKAHNNFDKEFTTEVVHLTPCDRAVIKVINQDDFKGFSFTNEE--------- 'O.carmela_PKCD' MA----------------------TKKKAFARVKILEVKFRPGDR-----------------IDPYVAVEIKESVME-NG-KTKLVQKK--PSFYPDWGQCFDSH-LAAGRHIRVAVFDR-------PEEFLADTTTPIDSLVEQCIGK--PNQLTRITLDLKPEGKLILQVKLFGEREEAVARD-------IRPE----TLKRPDVRAKEMKD-AKKTGTATLGLK--GRRGAV--KHQKVYQVKGHKYLAKYFRSPAYCAYCKEFLWGF-RKPGLQCKECASAVHLRCYKSVLG--ICPGAK--GDTH-----------HTK-----FLKERFGINVPHRFRVNNFFRPTFCDHCGTLLAGLFRQGVKCG--VCGFNCHKRCQTKVPNLCGVNEKL----------------------------------------LSEALQRIGTPGARKAKKDK-EDKKK-KDRLMKM-----GSSMPEMSG----------------GADAPPLPPRGP-----------LERGSSSFE---------------------------------------------------------------EMPEDLPFKLGAPKENPY-----------------------------------DVSDIYE----------------------------------------------SIAIVR----KEI-----PVLSKLTQSDFTFLKVLGKGSFGKVMLAQLKK-TGEYFAVKALKKDVVLEDDDIECTMIEKRVLAL-----SCSHPFLTHLHSCFQTQEHLIFVMEYLNGGDLMFHIQQSTRFDEARARFYSAEILLGLQFLHGKGILYRDLKLDNVMLNHEGHIKIADFGMCKENVV-GGSTTQTFCGTPDYIAPEIVEGKRYNRAVDWWSFGVLVYEMMIGQSPFS---------GDDEDDLFDSILHDEVTYPRWLSMEAVSFISKLLDRDPATRLGMRED---EEPIRKERFFQSMDWVKLEKKQIEPPFKIDIKSPGDASNFDDEFTVEPPVLTPADKDLIMSIDQGQFQGFSFTNPMFDDSK---- 'O.carmela_aPKC' MT-----------------------SLSQPIPVKVVFKG---------------KDTIAE--LDRSSSIEDFAQEMR----ILCRLEEG--QQFTMKWVDEEGDP-----------------------------CTIS-------------------------CQDELEESVRLFDSNHDTEL-----------------TLHIFDALPPAPGLPCEGEDR---SAY--RRRGAR--RWKKLYRVNGHAFGAKRL-YNAFCLYCRDRIWGL-GRQGYKCQNCKLVLHKKCLKFVRK--VCEGHP--PLPRAG-------PHGQLENIPEAENSSLKVQ-----------------------------------------SHK----------------------------------------------------------NSPKPGSRGNRK-------SPIPR-NSSDAVEAD----------------------------ATPPPPM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFRGQISLNNFDILNVIGRGSYAKVLLVELKK-TKALYAMKVIKKELINDDEDIDWVQTEKHVFEQ-----ASNHPFLVGLHSCFQTESRLFFVIEYVSGGDLMFHMQRQRRLPEDHARFYSSEIVCALNYLHEKGIIYRDLKLDNVLLDAEGHIKLTDYGMCKEGLR-PGDTTSTFCGTPNYIAPEILRGEDYDYCVDWWALGVLMFEMLAGRSPFDVVSNNENPDQSTEDYLFQVILEKTIRIPRSISVKAGSVLKGFLNKVPVDRLGCHPQ-TGFSDITEHQFFRPVDWESLERRQVTPPYRPCGDDKRDVGNFDPQFTSEPLEFSPDDRRVIEAIDQSEFEGFEYINPLLMSAEDTV- 'O.lobularis_KPCE' MA--------------------NKKTFSGTLHVKILEASALKPPT------IPGGITLTT--IDPYVRVSYDDIFLE------QTKSKD--KTTNPLWNEEIEGE-LYRAENLEITVFHKS---LVPPEPFVANVSIPFEEILSGC----EKGHFQDYWLELEPSGKIHVAVSFSKMSAETL------------------------------GRVFKQNTQ-GWGQR--GRQGAL--R-RKIHAVNGHKFMATYLRQPTYCSHCSDFIWGLVNKQGYQCQVCLAVVHKRCHQLVVS--TCTGQK--TERSEK---------DIE-----MAGHRFQLNMPHQFEDHNYKIFTFCDHCGSLLWGLRKQGMRCK--CCKLNVHKRCKTKVANNCGINPRI----------------------------------------LADKLAEIGQSADQLIQNSF-RSKQS-ISSRGAA-----SAGEAKTSSAEN-------------HASSSSSGSS-------------------------------------------------------------------------------------------------------------------------------------SIISKASTRIPP---------------------------------------------SKPAPT------RP-----KTS--QTVNDFSFLKVLGKGSFGKVLLAEHKA-TKEVYAVKVLKKVVICRDDDIECTMTEKRVLAM-----ACEHPFLTALHSCFQTKDCLYFVMEYVNGGDLMFQIQRSRKFDEARSRFYSAEIVSALSFLHSRGIIYRDLKLDNVLLDVDGHVKVADFGMCKEDII-DDKLTNTFCGTPDYIAPEILQEQNYGASVDWWALGVLMYEMMAGQPPFE---------ADNEEDLFDSIINDDVLYPVWLSKEAASIIRGFLTKSPSRRLGCQPG-VGEKVIRSHPFFRAIDWIALEARQVRPPFRPKVSDKRDVGNFDKDFTQEKAVVTPTTKQDMEIVNQEDFAGFTFVNDRFH------- 'O.lobularis_KPC_A-B-G' MG-------------------------------------------------------------------------------ATAHANESLPRVIDPSY-----------------------------------------------------------------------------------------------------LAMAEPTNDELPRSPSLPND-----GFQ--RRRGAI--RHKEVHTVKNHKFVARFLKQFTFCAHCKDFIWGLVGRQGFQCQVCGLVVHKRCHKLVTF--QCPGAD--IGPASD-----------------------APQSMHHFKIHSYGSPTFCDHCGSLLYGLFNQGLQCE--ECRMNVHKRCERLVPNLCGQDHTERRGRLSLAISYVATSTILG--KLRVEIREGKNLPPMDPNGLSDPYVKLRIVPDPDK-----STKKK-TAIK---------------------------------KGTLNPVFNEAFEF----------HVSTAKQD-------------------------HRLSVEVW-DWDRTTRNDFIGSMSFPLREFLA------GASMSGWYKLLEESKGAHYYEPCAEDEKEDEEGARGLES--------GRVNDVPRSPSLQ---QFQSDPSSS--------------------------------KQPLSPT-----SPG-----DGSRKYGLKDFNFMVVLGKGSFGKVMLAELKGTQDRYYAIKVLKKDVVVQDDDLECTLIEKRVLAL-----QGKPPFLTALHSTFQTEGRLFFVMEYVNGGDLMFHIQKVGRFTEPQASFYAAEIIVGLLHLHSNGVIYRDLKLDNIMLDSEGHVKIADFGMCKENIR-EGQTTRTFCGTPDYIAPEIIAYQPYGSSVDWWALGVLLYEMLIGQPPFN---------GRDEDELFDHILQKQPHFPKWLSKEAVDVCKRLMAKHAPRRLGCGA--TGENDLKTHPFFRKFDWEKIERREVAPPFKPKIKSKKAHNNFDKEFTSEAVHLTPCDRSVIKVINQEDFKGFSFTNPDFV------- 'O.lobularis_PKCD' MA----------------------TGKKAFARTKILEAKFVAAD-------------------DPYVAVEIKESIVE-NG-KTKLVQKK--PTFYPDWGQCFDSH-LARGRQIRIVVYDK-------PEEYRAETMKSIDDLVDECIGK--PNQLTRLSLDMKPEGKLVLQIKLFGEKEDVVARE-------IKAE----TLKRPDVRAKEMKA-AAKSGTATLGMK--GRRGAV--KHQKVYQVRGHKYLAKYFRKPAYCAYCKEFLWGF-RKPGLQCRECGSAVHLRCYKSVLG--TCPGAK--GDTH-----------HTK-----FLKERFGINVPHRFRMHNYFRPTFCDHCGTLLAGLFRQGMKCS--VCGANCHKRCQLKVPNLCGVNEKL----------------------------------------LSEALQRIGSPGARKAKKEKDEKKKK-KDQIKKM-----GGSL-DVET----------------KPPLPPLPPRGQ-----------L-RLSQSFD---------------------------------------------------------------EVPEELPFSLGAVKENAY-----------------------------------DVSDIYE----------------------------------------------TIAEVQ----KEI-----PKLSNLSQSDFTFLKVLGKGSFGKVMLAQLTK-SGEYYAVKALKKDVVLEDDDIECTMIEKRVLAL-----ACTHPFLTHLHSCFQTQDHLIFVMEYLNGGDLMFHIQQSTRFPEERARFYSAEILLGLQFLHGRGILYRDLKLDNVMLNHEGHIKIADFGMCKENVI-GGGTTQTFCGTPDYIAPEIVEGKRYNRAVDWWSYGVLVYEMMIGQSPFS---------GDDEDDLFDSILHDEVTYPRWLSMEAVSFISKLLDRDPTMRLGMREV---EEPIREERFFRTIDWIKLEKKQIEPPFKPEIKAAGDASNFDDEFTVEPPVLTPADKELIMSIDQAVLWLV--------------- 'O.lobularis_aPKC' MT-------------------------NQPIPVKVVFKG---------------RDSVAE--LDRESSIEDFAQEMR----ILCRLDEG--QEFTMKWVDEEGDP-----------------------------CTIS-------------------------CQEELNESVRLFDSNHDTEL-----------------TLHIFDALPPAPGLPCEGEDR---SAY--RRRGAR--RWKKLYRINGHAFGAKRL-YNAFCLYCRDRIWGL-GRQGYKCQNCKLVVHKKCLKFVRT--VCEGHP--PLPLAG-------HHGGLDQIPEVENNARKEHLS-----------------AAVLSG---------------GMHK----------------------------------------------------------SSPKSSHRGGRK-------SPHPV---SDVAEAD----------------------------ASPPPPI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFKGQISLDNFVILNVIGRGSYAKVILVELRK-TRALYAMKVIKKELINDDEDIDWVQTEKHVFEQ-----ASNHPFLVGLHSCFQTESRLFFVIEYVSGGDLMFHMQKQRRLPEDHARFYSSEIACALNYLHERGIIYRDLKLDNVLLDAEGHIKLTDYGMCKEGLR-PGDTTSTFCGTPNYIAPEILRGEDYDYCVDWWALGVLMFEMLAGRSPFDVVSNNENPDQSTEDYLFQVILEKTIRIPRSISVKAGSVLKGFLMKVPSERLGCHPQ-TGFSDITEHQFFRSIDWESLERRQVSPPYRPCGDDRRDVGNFDPQFTSEPLEFTPDDRRVIEAIDQSEFEGFEYINPLLMSAEDTV- 'O.minuta_KPCE' MD----------------------LRFSGRLYIRILDAQELPPGCLA---R------NAT--LDPYVRIDVDEILFA------STTVYP--KTLNAHWNESFEES-VIEGEILGLTVFHSS---LIPPDPFIAHATISLAELSTN------IDETRDVWCDLEPSGKIHFTIEFIPEDEATTIKRMSRVF-------------------------VPIKSE---VLR-DHKRLAV--R-RKVHQVNSHKFMAVFFKQFTYCAHCKDFMWGLVNKQGYQCQVCHMAVHKKCHHLVLT--PCNKAT--LEPNSP---------LDE-----MKDLRFSINIPHRFVSSTSKKPSFCTHCGSLIWGLARQARLCS--ACGITVHKRCEDHVPHSCGLDHKK----------------------------------------MSDALALIAKSGAKLPTK---SQKSS-TLGRSKH-R-T-QISYDSTRSRDRELMSSADRVMLTRTHTPPQSFDKGFEFGSPVRLPPRPNVYPPIFKSLDAPHSPPRSKPARPAPPS----------------PKCTEDLHGFSVAA---RGKRS---------------LSRSTGNI----------------------------RDEDSNGDLPPRPPPPFNKDSFPKLKVVP----PPRPLTSPLNKSLGFTKFNDATSIVKSPPSPS-----RNS-----LNLKKCTLEDFKLLTLLGKGNFGKVILAKERK-SNNVVAIKVIRKDMTVANDDVVCAFIERNVLAK-----THLHPFLTKMYCSFQTEDRLYYVMEFVNGGDLLYHMQEKRKFGETMTKFYSAETIDAVLYLHSKEIIYRDLKLDNILLDSKGHVKIADFGMCKMGIS-GSKLADTFCGTPDYIAPEILKEEPYGKSVDFWSFGVLMYEMLTGQPPFE---------GNTEQDLFNAILEDEVVVPPYISREATNIVRGLLTKSPRRRLGCHSG-TGERAIRNHAFFTVINWSQLRKKELIPPFVPKVSNTADCTNFDPEYLNEKIVFTPCNPEMMYMMEENEFDGFSFTSPILSEILNS-- 'O.minuta_KPC_A-B-G' MA------------------------------------------------------------------------------------------------------------------------------EKFIRALSMSDTSFSLD-------------------------------------------------------------------------------DRR--QKHIAI--REKKRVQKRNHLFELHFFKQPTYCAHCHQFIYGC-GKQGFHCLRCSYAIHRHCVELVAF--KCPKFE--MESEHP---------DVK---------------QHDFRITNYSKFTFCDHCGQMLYGLYKQGYQCQGKVCGMNVHSYCREFVANLCGTGSNEKYGQLMLNFLCHIDTETKG--SIYVDIKSGKNLMAADSNGLSDPYCKIKLKDSKGKT----TIKHQ-TKVH---------------------------------KKTLNPTFDESFEI----------PFNPS-VD-------------------------GRLEIWMW-DYDNALQSDNIGGMSFSIEELKTL-----KTGEDIWYALINPSSAKFMNQRSLSEADEGER-ERIVKEI-------ETIREKNRSRFEK---------------------------------------------SEHKMK-----RSF-----SNLNTLSVDDFDRIELLGRGAFGKVVMVEYKRIPDKIFAMKIMHKDLIFEYDAVDCTMIEQRILAM-----EEKPSFMTSLKASFQDEENLYMVMEFLCGGDLLFHLIQNTNFSEARSKLYIAEISFGIFYLHKQGIVFRDLKPDNVLLDIEGHVKLADFGLCKESIYHGKSNTTSFCGTIDYMAPEIVARKPYDTAVDIWSMGVLLYEMLVGRPPFI---------GRTDDAIIKNLLTKNPTFPTYLSPNAINLITQLLKKAPTERLGVDSK-SGEADFRGHAYFSNLDWSKAEKREIQPSFVPKITSKRSDAYFDAEYTKASTKITKINPGNILVIDQEVFNGFEFTSEEILIKS---- 'O.minuta_PKCD' MS-------------------------GAFIRIKLIEVKFPLLKY------------NFL--NEPSPSVNIKEKENT-PG-GFEYIQKK--KTFFPDWGRCFDSH-IHEGRRMQIIIMD-------PPETPVSQVTVDLTTLAEHYRSD-STGNAVKLALDLTPSGQIIIQVKVYGDKGEDEC--------------------IAESQPFVPSSELPKNAT---ALR--GRRGAI--KLGNANEVQGHLFLKKFFRQPVYCSLCHEFIWGF-GKEGWQCKQCAYVVHGRCLNLILS--KCPKAA--KNNQ-----------NTI-----FLKERFKLDVPHIFSVHSFSSLTFCELCGQVLWGLFRQGMQCE--VCGVTCHRRCKSDMPNLCGVNQKL----------------------------------------LAEALLVIKSQKH--------STKGK-NTNE--------DQEENNIDDKV--------------IRSKMPLPD--------------------------------------------------------------------------------------------------------------------------------------------LPPHDTDN------------------------------------------RQFPGSK-----DNP-----SALPKFKLDDFDLVKLLGKGSFGKVFLAQLNG-STQYYAIKALKKDVVLEDDDVECTMIEKNTLSI-----ASECIFLTHLHSTFQSLSHLFFVMEFLNGGDLMFHIQLSARFPEPRATFYAAEIVCGLQFLHSKSIVYRDLKLDNVLLDSQGHVKIADFGMCKEGIS-QNHLTSTFCGTPDYIAPEIIQGKLYGVSVDWWSFGVLCYEMLIGQSPFQ---------GEDEDELFHSICNDSIDYPRWLSKDAINLVDKLLQRIPDQRIGCTEQ---IEPLRHHVFFRTIDWNLLENLKVQPPFKPKVRSSNDVGNFDADFTIEPPNLTPSDERIIQEMLQSEFDGFSFTNPNYKT------ 'O.minuta_aPKC' MA----------EVNSRTNMDSTGPNSITQIPINLVHKG---------------KERKCN--LPTYKQVEYVVQFTR----ETLKLHPH--QGINLKWIDDDGDP-----------------------------ITLE-------------------------SQRDWDELLRLFPYNQDGLI-----------------YFHVFEGPKPQPGQLCEGEDI---NLY--KRRGAK--RWKKQLRLNGHIFQAKRL-NTAYCIICNDHIWGL-GRQGFRCTQCKIIVHKRCVKFVRQ--ICDGQV----SRPD--------------------------------------------------------------------------------------------------------------------------------GTQVSDRQSSPR-------DERIR-RVRQ---------------------------------QPKGNPV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDSTISIDDFNILKVIGRGSYAKVLLAEQKK-TSKLYAMKVVKKELLTDEEDFDWVQTEKHVFEV-----ASNHPYLVGLHSCFQSESRLFFVIEFVRGGDLMFHMQRQRKLPEDHSRFYASEICLALNYLHERGIVYRDLKLDNVLLDEDGHIKLTDYGMCKEGLL-KDDTTNTFCGTPNYIAPEIIRGQSYSYSVDWWALGVLLYEMLVGRSPFDVTGH-HEAGDATEDLLFQMILEKTIRVPRSLSVRAANVLKGFLTKNPKERLGCHPE-TGFNDIKSHQFFRSIEWKQLEMREVESPFIPRTEDERDVINFDPQFTNEPLEFTPVDKGVLERIDQAEFEGFEYVNPLFMTQEDQV- 'P.ficiformis_KPCE' M-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVSPEQLN-----PQRKS-ICTKDHDHD---HSVENGLL-----------------KEPDVPLPQR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PQPGLI------PP-----NSGKVVTLDDFVFLKVLGRGSFGKVLLAEMKS-TDRVFAIKVLRKDVLQRDDDVDCVLTEKRVLAL-----AYQHPYLTSMHSCFQTEDRLFFVMEYVNGGDLMFQIQKARKFDEDRARFYASEIVLALFFLHNRGIIYRDLKLDNVLLDAEGHVKLADFGMCKENIR-EGRQTSTFCGTPDYIAPEILKEMDYGASVDWWALGVLMYEMMAGQPPFE---------ADNEDELFEAILHDEVLYPVWLSREANSILRGLLTKNPQRRLGCQQG-IGERQIKGHAFFRTIEWDKLEKKSIPPPFKPVVRGKRDFSNFDADFTHENPTLTPVEKNIVESIVQSEFDNFSYTNTEFTS------ 'P.ficiformis_KPC_A-B-G' MT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSNHDFKTTTFFHPMFCEHCGSMIYGLRKQGVKCA--SCGLCAHHRCKDIIPKTCGTHTQEKRGRILLGYYTQRFAEDKW--RINIEVLECANLPPMDPNGLADPYVKVCVIGKDGTDIV--CVKQK-TERK---------------------------------DKTLNPRFDETFFF----------DVSEQELE-------------------------NSIYIAVW-DWDRIGSNDYIGGLSLKLSEIIT--ETCEGQRVESWFKLLGESTARKQSFRIISDVEAE----KLIAEYQ------KTIKGNKLSALKA---ELN-LDF----------------------------------RRGSELN-----TDS-----HGLPKLSLEDFKLIVVLGKGSFGKVFLAEHKA-SKEVYAIKSLKKDLVVQEDDVECTLNERRVLAL-----RGKPPFLTSLHSCFQTRDHLFFVMEYINGGDLMFHILELGRFSEVQTRFYSAEIVLGLIYLHSRGIIYRDLKLDNVMLDHEGHVKIADFGLCKEGIM-GGSKTRTFCGTPDYIAPEIINYQPYDASVDWWALGVLTFEMLVGQPPFD------------------------------------------------------------------------------------------------------------------------------------------------ 'P.ficiformis_PKCD' ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAEALKSVDAIK---------RNKRM-SAGD-----------VHALSKGDV-------------QSRLPSVPDE-------------------------------------------------VYMEVTEEMTKFAL-------------------------------------------------------------------------ENKKPPVPP---RVQSYMAGINGGG----------------------------FRYPPPI------PS-----KPAKRFKLEDFKFVKVLGKGSFGKVLLAQLCGRGEQYYAIKALKKDVVLEDDDVESALVEKRVLAL-----GSDHPFLTHILCTFHTPSHLFFVMEYLNGGDLMFHIQVSHKFKLPRARFYCAEIICALQYLHSKGVIYRDLKLDNVLLDSAGHAKLADFGMCKE?---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 'P.ficiformis_aPKC' ------------------------------------------------------------------MSINDVSTEIR----RQLGLHNS--APFNLKYLDVEGDP-----------------------------VSVS-----------------------LEHQREWDEATRLHFYNQEKEL-----------------LLHVFEGPPPMPGALCEGEDT---RIY--QRRGAR--RWRKVRRINGHAFVAKRL-QTAYCAKCRERIWGL-GRQGYKCEACKMVVHKKCCYYLRQDDICEGHP--PVKSPG-------------------------------------------------------------------------------------------------------------------------------------DELSEKK-------LSDPF-HDFL-----------------------------------TTNPV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SESQISLDDFNILKVIGRGSYAKVLMVELKQ-TKRIYAMKVIKKELVMDEEDIDWVQTEKHVFEQ-----ASNHPFLVGLHSCFQTDSRLFFVIECVNGGDLMFHMQRHRRLPEEHARYYSAEISLALNFLHDRGIIYRDLKLDNVLLDQDGHIKLTDYGMCKEGLR-AGDTTSTFCGTPNYIAPEILRGQDYGFSVDWWALGVLLYEMLAGKSPFDV-GGHDMPDQSTEDYLFQVILEKTIRIPRSLSVKAAQ----------------------------------------------------------------------------------------------------------- 'S.ciliatum_KPCE' MS----------------------QGFTGTLSVNVIEAVDLPPST-----QLSGGKQLTC--IHPYCAISVDGNYVG------QTDHIR--DTHSPQWNQTTEESFVQNAMVVDVSIFHHA---TPPPDVFICNATVSLDDLLRG----------GDVELSLDPRGRIRIEASFKEGAGSSG------------------------------SKAFRERD----VVQ--KRRGAL--R-RKIHQAHGHKFVARFFGQFTYCAHCKEFMWGF-GKQGYQCELCTLVLHKKCHSLVLT--PCPGMA--EDVSVA---------SSA-----SNASGFKINVPHMFNETSYLSPTFCDHCGSLLYGLYRQGYKCK--SCKFNVHRKCKGNVPNNCGVKTKE----------------------------------------MASVLAAMGQSAEKLGERQP-DNAPR-QGPRP-------TSSFHDTS-----------------ARTLTPNHHM---------------------------------------------------------------------------------------------------------------------------------------AVTGTPSLPG---------------------------------------------AGSSPSV-SSGASS-----SQPMRVSSKDFNFIKVLGKGSFGKVMLAERKG-TEEVYAIKVLKKDVILQDDDVECTLTEKRVLAL-----AGRHPYLTSLHSCFQTPASLFFVMEYVNGGDLMFQIQKARKFDEPRARFYSAEIVSALLFLHSSGVIYRDLKLDNVLLDSDGHVKVADFGMCKEGIM-GGNLTNTFCGTPDYIAPEILQEMDYGASVDWWALGVLMYEMMAGQPPFE---------ADNEDDLFDAILNDEVLYPVWLSREAASILRGFLTKNPARRLGCTT--TGERAIKAHPFFKPVDWVALEAREVRPPFKPKIKSKKDVGNFDTDFTSEEAIVTPPEKGVIESLNQEEFFGFTYVNPDFAGNC---- 'S.ciliatum_PKCD' MA----------------------SGSASFLRIKILQADGLTGAF-----------------TDPQLSVNIKEGGKQ--GSDAAVQQKK--PTFYPEWGKCFDSH-LSDGRRMQIIVTDHD---ASAGGKKLAELTTLLESIADQCRTQ--GSGVAKMSLPMSPSGELVLQAKVYRSAT-LERQTSQAAAAIAAMETQPGDLELALCMEDKPDE-LHKNIT---MLR--NRRGAI--RHAKLHEVNGHRYKARFFRQFTFCAFCKEFLWGF-GKQGYQCEDCEQVVHKKCHLLVLG--KCPGAK--DREA--------RITSAQ-----DLHARFNIDMPHRFKVHNFFHPTFCDHCGTMIYGLFRQGLRCQ--TCHSNIHKRCERRVPNLCGINEKV----------------------------------------MSGMLADVSKEVEA---------KKSASPATKKKAMSPTSAAS---KP----------------SH-LAAQGKSSD-----------------------------------------------------------------------------------------------------------------------------------------AGSIDE----------------------------------------------GMGKV------SL-----SSKPKYRLADFHMLKVLGKGSFGKVMLAQVKK-SKQYLAIKVLKKDVVLEDDDVECTMIEKRVLAS-----TGGNPFLVQLHSAFQTEGHLFFVMEFVNGGDLMFHIQQQGRFNEDRTRFYVAEIVCGLQHLHGKGVIYRDLKLDNVMLSSTGHIKIADFGMCKENIS-GANTTSTFCGTPDYIAPEIIEGAQYNHTVDWWALGVLTYEMLLGQSPFS---------GDDEEALFGSIMNDEVVYPVWLMKESAAFVSKLLVRDPTRRMGSDPK-TGRQQIRSDAFFKTIKWDVLEACGIPPPFVPQVKSPGDAGNFDVDFTMEPAVITPTDDKLLKSMDQEAFTGFSYANETF-------- 'S.ciliatum_aPKC' MA------------------------LEGYVTVQVIFNG---------------KEHMMA--VNPITSFDEFTRDVR----TMCRLDKD--KDMTVKWVDEEGDP-----------------------------CTVE-------------------------SQSELEELIRLYFSHNVIEI-----------------NMFVFDTVPTAPGMACDGEHR---VAY--GRRGAR--RWKKLHRVNGHAFAAKRT-YTQFCALCNDRIWGL-GRQGYKCMNCKLVVHKKCYKFVHN--ICEGHA--PYLHGH--------QSDSD-------------------------------------------------------------------------------------------------------------------EENSRKEAAAKP-------SSASK-RSND---------------------------------GPAPSPM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENSSVISLADFDIVRVIGRGSYAKVLLVELKS-TNRLYAMKTIKKELITDDEDIDWVQTEKHVFEQ-----SSNHPFLVGLHSCFQTASRLFFVIEYVNGGDLMFHMQRQRRLPEDHARFYAAEISLALNYLHEKGIIYRDLKLDNVLLDSEGHVKLTDYGMCKEGLR-PGDTTSTFCGTPNYIAPEILRGEEYDWSVDWWALGVLMFEMLAGRSPFDVVSGNDHGEQSTEDYLFQVILEKTIRIPRNISVRAGNVLKSFLEKNPKERLGCNPT-TGYSDITSHIFFRNVDWELMENRQFPPPYKPPLTDERDLANFDPQFTTEPLEFTPDDPKTLASIDQSEFEGFEYVNPLLMSKADDV- 'S.domuncula_KPC_A-B-G' MS----------------------------------------------------------------------------DSG-----------------------------------------------------------------------------------------------------------------------------------------------QVRRPKRRNAV--RQRQVVEIRGHKFVLNYFKQFTFCGHCTRFLWGVTGPQGYKCLLCDLAIHRRCMEYVSF--ICPGTS--LPEGIE-------------------------PRPHKFRATTYHTPTWCDHCGSLLYGIIRQGVQCS--DCGINVHHRCKGLVPKTCGLGQSEKRGRIKVTFSTLQLDDAHI--RVNIMIHECRNLPPMDANGLADPYVKLRLYPEPTD-TP--NIKQK-TERK---------------------------------EKTLEPKFEEDFFY----------DVNMNHLD-------------------------TFLVIEVW-DWDKFTANDYVGGFALRIGEIIE---LTKMEPHSSWYKLLDEKRSKTHHERILADEEAT----KLIEEFR------KATILDKAKNLVT---DVP--IM----------------------------------RRGSELV-----PGA-----KDMPKMKLEDFNLLVVLGKGSFGKVFLAEQKT-TKDVYAIKSLKKDLIVQEDDVECTLNERKVLAL-----QEKPPFLTGLHSCFQTRDHLFFVMEYINGGDLMFHILELGRFPENQTKFYAGEIVLGLRFLHKRGIIYRDLKLDNVMLDADGHIKIADFGLCKEGIL-GGNKTRTFCGTPDYIAPEIISYQPYDAAVDWWALGVLTYEMLVGRPPFD---------GDDDDQLFNNIMEKPVHYPRGMSDPAKKIIQGFLTKHPSRRLGCHPE-TGEQDIKGAPFFKSIDWDRLGRRELKPPYKPKIRGKKSVSNFDPEFTKEPCRLSPVDPTVIGAIEPEVFEGFSFTNPEMYHEP---- 'S.domuncula_PKCD' MS--------------------------AFLRVRLSEAIVDHTKP-----------------NDPFCAVNIKEAVKGDDG-TLSLQQKK--KTFYPVWGRCFDSH-LKPGRRMQIIVMDRADV-PGADVTPVAEVTVETEQLAHECMDE-EPGVAVKLALDLRPSGKVIMQVKLYGTAPGSDESS---------------GIDFATRTPEKLSS-LPKNAT---ALR--GRRGAVNRRQAEAKEFKGHMFIKKFFRRPTYCSLCREFLWGY-TRHGYQCQVCQYTSHKRCIDSILG--KCTGAA--GTSN-----------HSK-----YLKERFKIDVPHRFKKYTFLGPTFCDMCGQLMHGIFRQQLKCD--ACGTNCHTKCAQNMPPLCGVNEKL----------------------------------------LSEALKNVDEIK---------RNRRL-SAGG-----------DPSQNGKKS-------------TPALPPVSEGGLIE-------------------------------------------EDEYQEITEAMSQASL-------------LVKL-----------------QQEQSASHVPSPQNGNKHRP---------------LSSTSEAAPPVPP---RTYSQKSHMNGQS----------------------------SSFSRHM-----PVS-----KPMRRFKLEEFQFLKLLGKGSFGKVLLAQQIG-SNKYYAIKALKKDVVLEDDDVEATMVEKRILAL-----GSECPFVTHLHSTFQSSSHLFFVMEYLNGGDLMFHIQLHHKFKLPRARFYAAEILAGLQFLHSKGIIYRDLKLDNILLDSEGHCKIADFGMCRENIF-GSSTAGTFCGTPDYISPEIIKGKRYTFSVDFWSYGVLCYEMITGQPPFG---------GEDEDELFDSICNSQIPFSRYLDAYTIDFLDKLLQREPIQRLGYMGD---RQPIRKHPFFRSIDFARLEKREIAAPYKPVVKSAQDASNFDDDFTFQPAQLTPTDTQLVLSIDQTNFNGFSFTSEAFNKP----- 'S.raphanus_KPC_A-B-G' MS----------------------------------------------------------------------------------RVSRN-------------------------------------------------------------------------------------------------------------------SSSSEVNYRDDAPAGAA---FAR--GRRGAV--KKKNIVNVRDHEFEPRFFKQPTFCAHCKEFIWGV-GRQGYGCRVCQFAVHRRCHEFVSF--TCPGAE--KPDE-------------------------GASSPHKFKVTSYGQPTFCDHCGSMLYGLVKQGLKCQ--ACEMNVHKRCERFVPQLCGCDHTEKRGRLFLGLKLTETTPVLK--SLEVVVKEAKNLPPMDANGLADPYVKLWLSDDPQK-----ATKKK-TETK---------------------------------MKTLNPVWGEKFSF----------NLTQGDLK-------------------------RSLIIEVW-DWDRTTRNDFIGKMTFTLDEITKMEKDPASGFNDQWFKLLNESEGSAYNVPIMEGPLDSR----------------ASTRSGGSSTSPT---GDEDLSVGVGAL-----------------------------DVSGGPGNGGMPMDA-----LKGRKPKLSDFSFLKVLGKGSFGKVMLAQLKG-QEQYYAIKVLKKDVIVQDDDVECTMIEKRVLAL-----SGKPPFLTALHSTFQTKDRLFFVMEFVNGGDLMYHIQQQGRFKENVAVFYSAEIVLGLFFLHRHGVIYRDLKLDNVMLDHEGHIKIADFGMCKEGVL-GAKQTRTFCGTPDYIAPEIVAYQPYNGSVDWWALGVLVYEMLSGQPPFD---------GEDEDELFSSILGDEVRFPKSMTREACSICKSFLAKHPAVRLGCGP--NGEADIQGHPFYRTIDWTRLGRRELPPPFKPRIKSKNAANNFDKEFTDEHPKLTPCDRTVIAAIKDDVFGGFSYVNPDPVANG---- 'S.raphanus_PKCD' MA---------------------EAGDDSFLRIKILQATSLRGNA-----------------SDPHLAVNIKESIRTPGGKDVQVVQKK--DTFHPEWGKCFDSH-LNDGRRMQVMVTDIVGD-GVMESTQLGEVTVLLASIADQCRSQ--GSGVSKMSLDMQPCGELTLQAKVYHSQKSGQPES---------APPVPGGIESAQCMEENPEE-LHKNIT---MLR--NRRGAI--RHAKLHEINGHGYKARFFRQPTFCGFCKEFLWGF-GKQGYQCSYCDQVVHKKCHAKVLG--KCPGSK--ETKDKNVI----KKSSQL-----DLKARFNIDMPHRFKTHNYLHPTFCDHCGTLLYGLFRQGLQCE--VCKANCHKRCQGSMPNLCGINEKM----------------------------------------MAEMLADVSKEVEA---------KRS-SPATKKK-----GMGR---QA----------------STPVSPLSQAPK------------FGQANRFEPM-------------------------------------------------------------------------------------------------------------------AMSLDE----------------------------------------------SMARA------AI-----ASSKRYTLSDFHLLKVLGKGSFGKVMLAQVKK-SKQYLAIKVLKKDVVLEDDDVECTMIEKRVLSS-----TSIHPFLVHLHSAFQTEGHLYFVMEYVNGGDLMFHIQQQGRFSEDRTRFYVSEIICGLQHLHSRGIIYRDLKLDNVMLSSRGHIKIADFGMCKENIC-GENTTSTFCGTPDYIAPEIIQGEQYNHSVDWWALGVLTYEMLLGQSPFS---------GDDEESLFQSIMNDQVVYPVWLTREAAAFISKLLVREPDKRLGSDPK---QSNPRGEAFFKTIDWAKLERAEIAAPFVPNVKSAGDACNFDVDFTMEPAVITPTDEKLLKSMDQEPFNGFSYVNDYFPDQ----- 'T.adhaerens_KPCE' MS------IN-----------------------------------------------------------------------SVTPLTKH---------------------------------------------------------------------------------------------------------------------------------------HTW--TRQGAF--KRKKVHEICGHQFVATYFRQFTYCSHCKEFIWGVIGRQGYQCRSCRIVVHKRCHQLTVT--KCTSNL--PEDE-----------DST--------IGFNINVPHNFATHSYRSPAFCDHCGSLLYGLFRQGKQCK--ECKRNVHFRCIQYVPNDCGINKAQ----------------------------------------VGAALAAIGRSSDFLH-----KNSIS--------------------------------------SADEKPVYLK-WHF----------NFSSVKFE-------------------------NYIKIYIC------------------ITLLIRM----------------------------------------------------ERVFDRSKRKLQE---KLSHHQ-----------------------------------------------THA-----DNKKIHSIDDFKFLKVLGRGTFGKVMLGELKS-TGDVFAIKILRKESVLQDDDAECAIMERRILAL-----SIKHPFLVGLYCSFQTTHRLFYVMEYANGGDLMFQIQKYSRFNEEKTRFYSAEIVLALQFLHQNGIIYRDLKLDNVLLDSEGHIKITDFGMCKENMF-GSCLTKTFCGTPDYIAPEILLEIDYGFSVDWWSLGVLMYEMLAGEPPFE---------GDSEEELFESILHNDIHYPVWLSREALRILKGLLIKNPGKRLGCTLS-KDENSIRDNAFFTNINWAKLEKREVIPPVIPNVKNRYDCSNFDEEFVNEKPILTPTGDSTLDSIDQQEFQGFSFVNRGNIKFY---- 'T.adhaerens_KPC_A-B-G' MT-------------------------------------------------------------------------------TITTVGSA---------------------------------------------------------------------------------------------------------------------------------------KPF--LRRGAV--RQKNVHVVKDHKFIPRYFKQLTFCAHCRDFIWGIVSKQGFQCQDCGFAVHKRCHEYVSF--RCPGAE--SASSTH-------------------------SSPHKFKVWTYGSPAFCEHCGSLLYGLFHQGLKCE--SCDINVHKRCKKFVPNLCGSDHTERRGRINLSIRYQETSPTAG--MLLVEVRECKNLIPMDPNGLSDPYVKIKLLPDPNK-----STKRK-TPIC---------------------------------KATLNPIFNMKFDF----------YITEKDHE-------------------------RRLNVSVW-DWDKFGGNEFMGALSFGVSELIR-------RPVEGWYKLLDQGEGEFYNVPIADDAAV-----ALQEKF----------KSLEMRPKPA---QVKHLNF-----------------------------------------------------PNSSQLTRMEDFEFLSVLGKGSFGKVLLAQKKG-TEEVYAIKILKKDVIVQDDDVECVMVEKRVLAL-----SGRPPFLTYLHSCFQTEDRLLFVMEFVNGGDLMYHIQQVGRFKEPQAAFYAAEIVVGLLYLHSKGIIYRDLKLDNVMLDSDGHIKIADFGMCKEGMT-PGKTTRTFCGTPDYIAPEIVAYQPYGKSVDWWALGVLLYEMLAGQPPFD---------GEDEDELFNAIMEHSISYPRCLSKEAVSIIKGFLTKNPAKRLGCGP--NGERDIKEHQFFRRIDWEKLSNREIQPPFKPKCKSYKSADNFDPEFTKESIALTPTDKTIIQNVDQSEFEGFSFVNPEFSGNE---- 'T.adhaerens_aPKC' MIKR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQEGGE---------------------------------WIM-------------LTDLLINHLLKA--AVTDKP-----------------------------------------------------------------------------------------------------------------------------------------------KEPRR-------ASKPK-PKPE-----------------------------------LKGPA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKV-----EPT-----PQEGQVSLEDFNLFKVIGRGSYAKVLMVQYKK-TKAIYAMKVIKKEIINDEEDIDWVQTEKHVFEI-----ASNHPFLVGLHSCFQTNSRLFFIIEFVNGGDLMYHMQRQRRLPEDHARFYAGEICLGLHFLHARGIIYRDLKLDNVLLDSTGHIKLTDYGMCKEGLG-PGDTTGTFCGTPNYIAPEILRGQDYSYSVDWWALGVLMFEMLAGRSPFDVAGNPDAEQSNSEDYLFQVILEKTIRIPRSLSVKAASVLKGFLNKAHEERLGCHPE-TGFTDIQSHVFFRQIDWEELEARQIPPPYIPQVENFQDLSHFDPQFTSEPTDFTPDDPFILEKIDQSEFDGFEYVNPLLMSEEDAV- ; END; [ The following blocks are output data for analysis step 22816 ] BEGIN TREES; TITLE tree_figure_3; LINK TAXA = TaxaForAnalysisStep22816; TREE con_50_majrule = [&R] ; [! TreeBASE tree URI: http://purl.org/phylo/treebase/phylows/tree/TB2:Tr111403] END;