#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 19, 2025; 13:33 GMT TreeBASE (cc) 1994-2008 Study reference: Stern A., Mayrose I., Penn O., Shaul S., Gophna U., & Pupko T. 2010. An Evolutionary Analysis of Lateral Gene Transfer in Thymidylate Synthase Enzymes. Systematic Biology, 59(2): 212-225. TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S10171] [ The following blocks are input data for analysis step 5409 ] BEGIN TAXA; TITLE TaxaForAnalysisStep5409; DIMENSIONS NTAX=184; TAXLABELS Acidianus_rodshaped_CAI44186 Acidiphilium_cryptum_ZP_01145406 Acidobacteria_bacterium_YP_593564 Acidothermus_cellulolyticus_ZP_01137552 Aeropyrum_pernix_BAA81074 Alvinella_pompejana_AAQ75147 Anabaena_variabilis_YP_323423 Anaeromyxobacter_dehalogenans_YP_464350 Anaplasma_marginale_Q5PBM3 Anaplasma_phagocytophilum_YP_504787 Aquifex_aeolicus_AAC06847 Bacillus_anthracis_AAT32922 Bacillus_cereus_AAU16821 Bacillus_weihenstephanensis_ZP_01186649 Bacteriophage_SPM2_CAF34258 Bacteriophage_Syn9_YP_717897 Borrelia_afzelii_ABH02196 Borrelia_burgdorferi_NP_045749 Borrelia_hermsii_AAT68707 Brevibacterium_linens_ZP_00380332 Caldicellulosiruptor_saccharolyticus_ZP_00884689 Campylobacter_coli_ZP_00368146 Campylobacter_concisus_ZP_01375100 Campylobacter_curvus_ZP_01376670 Campylobacter_fetus_ZP_01411215 Campylobacter_jejuni_ZP_01377925 Campylobacter_lari_ZP_00369618 Campylobacter_upsaliensis_ZP_00371809 Candidatus_Kuenenia_CAJ72160 Candidatus_Pelagibacter_ZP_01264826 Candidatus_Protochlamydia_CAF22879 Carboxydothermus_hydrogenoformans_ABB14922 Chlamydia_muridarum_AAF39712 Chlamydia_trachomatis_AAX50909 Chlamydophila_abortus_CAH64419 Chlamydophila_caviae_AAP05750 Chlamydophila_felis_YP_514918 Chlamydophila_pneumoniae_NP_224942 Chlorobium_chlorochromatii_ABB27663 Chlorobium_ferrooxidans_ZP_01385207 Chlorobium_limicola_ZP_00511556 Chlorobium_phaeobacteroides_BS1_ZP_00531300 Chlorobium_phaeobacteroides_ZP_00529968 Chlorobium_tepidum_AAM72779 Chloroflexus_aurantiacus_ZP_00768418 Clostridium_perfringens_ABG84971 Clostridium_sp_ZP_01362803 Clostridium_tetani_NP_783134 Corynebacterium_diphtheriae_CAE49993 Corynebacterium_efficiens_BAB88822 Corynebacterium_glutamicum_CAF20313 Corynebacterium_jeikeium_CAI37294 Cyanophage_PSSM2_YP_214554 Cyanophage_PSSM4_YP_214756 Dehalococcoides_ethenogenes_AAW39323 Dehalococcoides_sp_ZP_01138669 Deinococcus_geothermalis_YP_605490 Desulfitobacterium_hafniense_YP_516682 Desulfotalea_psychrophila_CAG36957 Desulfotomaculum_reducens_ZP_01150252 Desulfovibrio_desulfuricans_ABB39118 Desulfovibrio_vulgaris_AAS96727 Desulfuromonas_acetoxidans_ZP_01311759 Dictyostelium_discoideum_XP_641335 Ehrlichia_canis_AAZ68718 Ehrlichia_chaffeensis_ZP_00544975 Ehrlichia_ruminantium_CAI27208 Ferroplasma_acidarmanus_EAM93455 Frankia_alni_YP_715896 Frankia_sp_EAN1pec_ZP_00571881 Frankia_sp_YP_482628 Geobacter_metallireducens_ABB30621 Geobacter_sp_ZP_01389528 Geobacter_sulfurreducens_AAR36497 Geobacter_uraniumreducens_ZP_01142218 Gloeobacter_violaceus_BAC90262 Gluconobacter_oxydans_AAW61178 Haloarcula_marismortui_AAV46077 Halobacterium_salinarum_AAK00648 Halobacterium_sp_AAG19665 Halovirus_HF1_AAO61355 Helicobacter_acinonychis_YP_665477 Helicobacter_hepaticus_AAP77717 Helicobacter_pylori_NP_208323 Herpetosiphon_aurantiacus_ZP_01426098 Jannaschia_sp_YP_509033 Lawsonia_intracellularis_YP_595563 Leptospira_interrogans_NP_711714 Magnetococcus_sp_EAN29948 Moorella_thermoacetica_YP_431307 Mycobacteria_phage_AAC18488 Mycobacteriophage_Catera_YP_656098 Mycobacteriophage_Che12_YP_655630 Mycobacterium_avium_NP_961799 Mycobacterium_bovis_CAD94960 Mycobacterium_flavescens_ZP_01194553 Mycobacterium_leprae_CAC30465 Mycobacterium_phage_Bxz1_NP_818164 Mycobacterium_phage_L5_CAA79424 Mycobacterium_phage_NP_817637 Mycobacterium_sp_YP_639279 Mycobacterium_tuberculosis_ZP_00770421 Mycobacterium_vanbaalenii_ZP_01208056 Nanoarchaeum_equitans_AAR38870 Neorickettsia_sennetsu_YP_506060 Nostoc_punctiforme_ZP_00106512 Nostoc_sp_BAB72473 Oceanicola_granulosus_ZP_01156549 Paracoccus_denitrificans_ZP_00633170 Paramecium_bursaria_2CFA_B Pelobacter_carbinolicus_YP_358099 Pelodictyon_luteolum_ABB23254 Pelodictyon_phaeoclathratiforme_ZP_00588145 Pelotomaculum_thermopropionicum_GAA00501 Physarum_polycephalum_AAY87038 Picrophilus_torridus_AAT43321 Prochlorococcus_marinus_ZP_01006033 Prochlorococcus_marinus_str_MIT_9312_ABB49306 Prochlorococcus_marinus_str_MIT_9313_NP_895377 Prochlorococcus_marinus_str_NATL2A_YP_292800 Prochlorococcus_marinus_subsp_marinus_str_CCMP1375_NP_874667 Prochlorococcus_marinus_subsp_pastoris_str_CCMP1986_NP_892362 Prosthecochloris_aestuarii_ZP_00590908 Prosthecochloris_vibrioformis_ZP_00660891 Pyrobaculum_aerophilum_AAL63766 Pyrococcus_abyssi_CAB50208 Pyrococcus_furiosus_AAL80664 Pyrococcus_horikoshii_NP_142699 Rhodococcus_sp_ABG98518 Rhodospirillum_rubrum_YP_427876 Rickettsia_akari_ZP_00340125 Rickettsia_bellii_ZP_01380446 Rickettsia_canadensis_ZP_01347808 Rickettsia_conorii_AAL02943 Rickettsia_felis_AAY61342 Rickettsia_prowazekii_CAA14762 Rickettsia_typhi_AAU03772 Roseiflexus_sp_ZP_01355916 Roseovarius_nubinhibens_ZP_00960246 Roseovarius_sp_ZP_01038219 Rubrobacter_xylanophilus_YP_645362 Salinispora_tropica_ZP_01428560 Silicibacter_pomeroyi_AAV94565 Streptomyces_avermitilis_NP_823693 Streptomyces_coelicolor_CAA20294 Streptomyces_phage_CAA07140 Sulfitobacter_sp_ZP_00955358 Sulfolobus_acidocaldarius_AAY81629 Sulfolobus_solfataricus_AAK40656 Sulfolobus_tengchongensis_CAH04199 Synechococcus_elongatus_YP_171214 Synechococcus_phage_AAL73301 Synechococcus_sp_ABB34049 Synechococcus_sp_CC9311_YP_729554 Synechococcus_sp_CC9902_ABB27029 Synechococcus_sp_JA23Ba_213_YP_478001 Synechococcus_sp_JA33Ab_YP_473724 Synechococcus_sp_RS9917_ZP_01080929 Synechococcus_sp_WH_5701_ZP_01084768 Synechococcus_sp_WH_7805_ZP_01123511 Synechococcus_sp_WH_8102_NP_896374 Synechocystis_sp_NP_440394 Syntrophobacter_fumaroxidans_ZP_00666252 Syntrophomonas_wolfei_EAO22970 Syntrophus_aciditrophicus_YP_462966 Thermoanaerobacter_ethanolicus_ZP_00779467 Thermoanaerobacter_tengcongensis_AAM25376 Thermobifida_fusca_AAZ55425 Thermococcus_kodakarensis_YP_183283 Thermoplasma_acidophilum_NP_394882 Thermoplasma_volcanium_BAB60613 Thermosynechococcus_elongatus_NP_681946 Thermotoga_maritima_1O2B_D Thermus_thermophilus_BAD70919 Thiomicrospira_denitrificans_ABB43298 Treponema_denticola_NP_970925 Treponema_pallidum_AAC65955 Tropheryma_whipplei_NP_787744 Wolbachia_endosymbiont_ZP_01314862 Wolbachia_endosymbiont_strain_TRS_Brugia_malayi_AAW71329 Wolinella_succinogenes_CAE11216 Xanthomonas_campestris_YP_239317 delta_proteobacterium_EAT05671 uncultured_bacterium_AAR38374 ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M4593] TITLE ThyX; LINK TAXA = TaxaForAnalysisStep5409; DIMENSIONS NCHAR=1152; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 1150 ] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] Acidianus_rodshaped_CAI44186 ---------------------------------------------------------------------------------------MVSVSLVSYTQ-------------------------------------NGEKVVAIASKMSR-------------SRKGWK---------------HHEETM-----TEDEIETWIRDAI--IHGYWSPLE------------HSNY----------------------------------------------------------------------------------------------------------------TFSIEG-----------------------------------------------------------------------------------------------------------------------------ISRVASHQL-VRHRI-ASYTQMSHRFAKPID-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EYYQ------------PIIPPSA----------EKRN------------------------------------EEIIKNAYKDAYDLYYDLLQ-------------------------------------------NGVPEEDARYILP-NGVNTNIVVTMNARE-LYN-FFGL-RLC--------SRAQWEIRAVAWKMLEEV---KRVHPRL-FKYAGPNCIIHENFIR--ETPITLDNL----SGE-FLSQRCIEGVPRDGIKKCILNSRHVS------------------------------------------------------------- Acidiphilium_cryptum_ZP_01145406 --------------------------------------MPLSDSDRTEIEAARAETTPTRRATVPTLEAM-----LFS--AIPVLDH-GFVRVVDYM--------------------------------------GDDAAVVQAARVSY-------------GRGTRK---------------------------VSEDEGLIRYLM--RHRHSTPFE------------MCEI----------------------------------------------------------------------------------------------------------------KLHVK------------------------------------------------------------------------------------------------------------------------------LPIFVARQW-IRHRT-ANVNEYSARYSVM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-RE------------FYIPSPA--------NLAAQSASNRQGR--GD--LLEGDEASE-------------VLAMLRADAERNYNHYERML--------------------------NE--------GGADPS-RRGLARELARMNLT-LNTYTQWYWKTDLHN-LFH-FLSL-RAD--------PHAQYEIRAYAEAILDIA---RAWVPAS-CRAFEDYRMGAATFSA--TMLAALRRMLAGEPVDQ-AQS-GLSKREWAEMMAALTPPTPG-------------------------------------------------------------- Acidobacteria_bacterium_YP_593564 ---------------------------------------------------------------MSSAVSPMSTSSEKAEQTKPEEQAGTQVYAIHGA--------------------------------------DPEVLAYAMAKYSR---------------------------------SALSMKESLTELNAQKAEKFLNTFY-FQYGHRSIAD------------LAHI----------------------------------------------------------------------------------------------------------------AMAIES-----------------------------------------------------------------------------------------------------------------------------LSLLAATIV-VDESR-WDGQERSTRYQNFRKSGYFT------PDFSGDAGAETLYRDTVNFLFAEYENFSEGMFRYLEGQTPKPD--------------------DMKQDAYERTLRARAFDLSRYILPLATNTSLGQIVNARTLETQVSRLLSHTHKEVRDLAQKLKDAAREPSHNVNHAAMRELIAEIREKDADLAARAEEQLLREVRVSPTLVKYAEANAYEIETRKLLQQAASELMKGAAIEPAKEVDLLEPDPLEIELATTLLYQGSQYSYRQLRRAVESLTADERQEIIDLGVQNRGKHDELSRAFNAGQQFRFDILMDVGGYRDMHRHRRCVQVHQPYTAAHG----FAMPEEMADAE---------------------------------------------VDERYQQTMQRAADAYTKIAGSP-----------------------------------------IAEANEKAQYVLP-LAYRKRTLFKMDFAE-VVY-ISEI-RTT--------PQGHYSYRNVAWQMYDEV---ASKHPSL-RSYFRVTDVHEPVDLL--KR------------------------------------------------------------------------------------------------------ Acidothermus_cellulolyticus_ZP_01137552 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHADPARSKGLINYLM--RDRHGTPFE------------HNSM----------------------------------------------------------------------------------------------------------------TFYVQ------------------------------------------------------------------------------------------------------------------------------APIFVFREM-MRHRI-ASYNEESGRYRQL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPV-------------FYVPAPD----------RKLVQQGKPGH--YEFVDGTPEQYKI-------------VVEATKRACEEAYAAYLEML--------------------------N-----------------AGVAREVARGVLP-VAIYSSAYVTLNARS-LMN-FLSL-RTRRESSRFP-SFPQREIEMVAERMEAEW---ARLMPLT-HEAFEAHGRVAP-------------------------------------------------------------------------------------------------------------- Aeropyrum_pernix_BAA81074 ---------------------------------------------------------------------------MSLAASLEKAGLGISVRLLEYTG-------------------------------------DGERIVAVASKVSL-------------SRSPAE----------------RLLAI-----GEDEVETWILETF--RRQHFSPWE------------HSVY----------------------------------------------------------------------------------------------------------------TFMVEG-----------------------------------------------------------------------------------------------------------------------------LSRVASHQL-VRHRV-ASYTQLSHRYSEGYLREAALKACESIGLDCPSKPAETEGGRKAAYRLYSQALERAARDFGASERFAI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAKA------------FVIPPTI----------LARGD----------------------------------GGDGVVEAYLRSAAIYYSLLS-------------------------------------------RGARREDARYILP-DALRTRIVVTMNARE-LIQVFFPL-RMC--------TRAQWEIRHIAWLLWREL---SRVHPRL-FRWAGPSCVLRENTLR--TTPASLYSYLEGVERFTQPRCPELVENKAIPGCLRQAASVAPPGDGEYE------------------------------------------------------- Alvinella_pompejana_AAQ75147 ------------------------------------------------------------------------------------MELKMEIRLMHH---------------------------------------TPLDVCSFAIRTCW-------------QSFKNS-------------------DG-----GGDRDRELIDRVG-NRYRHSSTLE------------HLSY----------------------------------------------------------------------------------------------------------------TFYIRG-----------------------------------------------------------------------------------------------------------------------------VSRALLQEL-SRHRV-ASLSVKSTRYTLKELKGEDDF---TIDELSRVERYLVLT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNVDVDKASVDALNRLQLLL--------------------------K-----------------SGISNDIAKYALP-ESYKTELTWTINARS-LQN-FLNL-RSS--------KSALWEIRDLAHGVYNSL---PEAHKYL-FKEHLNAI------------------------------------------------------------------------------------------------------------------ Anabaena_variabilis_YP_323423 -------------------------------------------------------------------------------------MDRFRVEVIAKTP-------------------------------------NPQQVIYAAMHQDY-------------TDGFVF-------------DERDSWPS-----ESECGDIIIKRLLAGERGHYGPLE------------HPQI----------------------------------------------------------------------------------------------------------------VFNCGY-----------------------------------------------------------------------------------------------------------------------------FPHSVMQQA-RTHRVSVSFDVQSFRYTGNQFIDVVEGRKDI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDVF------------YLRPVGY-----------------------------------YTDRQGKKYYYSPEQRAADLQWCLEAAKRYKADFE-------------------------------------------GGMSEEHARGKVP-FDYRQHFVVSFNLRS-FLH-FCDL-RNK--------KDAQLEIQKLCELMWPHF---AEWSPAI-AQWYEKSRLGRARLSP---------------------------------------------------------------------------------------------------------- Anaeromyxobacter_dehalogenans_YP_464350 -----------------------------------------------------------------------------MRALPRSRSMPLEVTLIDYAR-------------------------------------DPLQKLYGAYRTCY-------------TPKTPG---------------EVWGEIRDGSISADRIRDFIGERL--KTGHASPLE------------QVVF----------------------------------------------------------------------------------------------------------------WFGISG-----------------------------------------------------------------------------------------------------------------------------VSRALSHQF-VRHRIGISFEQQSQRYVKYKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERLD------------YVMPKTW----------QKVAG----------------------------------MADEYDRLMREITRVYEDALA-------------------------------------------KGIPAEDARFVLP-NATPTNFQVMVNFTE-LLH-IADL-RLC--------WRAQWEIRHMVALMRREV---MKAVPEI-GGYLQPKCGDKRMGYC--DEPVKEWEACPLGKVRPHKEQLLQVFREYRAGNLVPLAEEHLRAVEDAGNEE---------------------------------------------------- Anaplasma_marginale_Q5PBM3 --------------------------------------------------MEEGTGEYTKRVVVHALEDI-----LHQ--ELRVLDK-GFVRVVDYM--------------------------------------GSDESVVQAARVSY-------------GRGTKR---------------------------TSQDAALIGYLM--RHAHTSPFE------------MCEI----------------------------------------------------------------------------------------------------------------KLHVK------------------------------------------------------------------------------------------------------------------------------LPIFVARQW-VRHRT-ASINEYSARYSVL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-RE------------FYIPDEK--------QIAEQSTNNAQGR--GT--PLPADAAKR-------------IMELFRRNSELMYEDYEALL--------------------------E-----------------QGLARELARMNLT-INCYTQWYWKVNLHN-LLR-FLAL-RSG--------AGAQYEIREYASRILEIV---RLWVPMV-HAAFVEYHLESSTISR--SALVVVRKMLQGEKVSM-EES-GLGRREWGELMSVLYPDGEPE------------------------------------------------------------- Anaplasma_phagocytophilum_YP_504787 --------------------------------------------------MVDEATEYTKRLVVPALENV-----LYQ--EHKVLDH-GFVRVIDYM--------------------------------------GSDASIVQAARVSY-------------GKGTKQ---------------------------VSQDAALIGYLM--RHAHTSPFE------------MCEI----------------------------------------------------------------------------------------------------------------KFHIK------------------------------------------------------------------------------------------------------------------------------LPIFVARQW-VRHRT-ASINESSARYSVV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-NE------------FYIPEAC--------DVAEQSSNNAQGR--GN--PLTSEVAQN-------------VIGMFKDNSDSMYASYESML--------------------------S-----------------DGVARELARMTLP-LNCYTHWYWKVDLHN-LLR-FVTL-RLG--------SGAQYELRAYAGKILDII---ALWVPMV-YAAYMEYCFESKTLSK--SALSVIRMLLKGEKVSR-EDV-GMSKREWGELMATLYPDE---------------------------------------------------------------- Aquifex_aeolicus_AAC06847 ---------------------------------------------------------------------------------------MMKIYLM-----------------------------------------GSDQRIVRCARVSF-------------AKDSYV--------------------------DEKRDKRLIRYLF--KHRHASPFE------------HNIIAFEWKKEKWIELLSKLENPTVQVYYSNGFVFLNLRNAINVWELLPDAVKERIKEAFPTTYGVIQRRGEIEDEELYSLPYTKDKAYVKEKIETSSGWIGLVDKLELETDMDFYTFVVE------------------------------------------------------------------------------------------------------------------------------CPLFVARQW-MRHRF-GSYNEVSKRYVGK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EFLE------------FYLPKYI----------RKQAEKNKQASV-DEPISESEV-----------------FIKKIENLISKSVKLYEEII--------------------------E-----------------KGGAKELARGVLP-QFMKTRFYWTVPRIS-LDN-FITL-RTH--------EGAQKEIREFAEAIKEMVGYRGTDKKNV--------------------------------------------------------------------------------------------------------------------------I Bacillus_anthracis_AAT32922 ----------------------------------------------------------------------------------------MDVKLLAHTQLSEEFVNYLSVVFGIGDEGFDPT--------------HGQVVALSAIRTCY-------------SPNKPS--RIVSLEGEKYFKGKATDGK-----GGKEVDRLIRHIV--GSGHASTLE------------HLTY----------------------------------------------------------------------------------------------------------------TFAVEG-----------------------------------------------------------------------------------------------------------------------------VSRALLAQL-TRHRVGFSYSVQSQRYVRMGSNDKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGFD------------YVVPETV----------KAKGEQ---------------------------------VVNAYNEMMYKLQSGYDLLR--------------------------T-----------------LGIPAEDARSVLP-NAAATNLVLTVNLRG-LLD-FYNKRRKG--------KGAQAEIAELAEQLRQEV---VKVEKWV-DEFFWKWKVTEV-------------------------------------------------------------------------------------------------------------- Bacillus_cereus_AAU16821 -----------------------------------------------------------------------------------MENLNMDVKLLAHTQLSEEFVNYLSLVSGIGEEGFDPT--------------HGQVIALSAIRTCY-------------SPNRPS--RIATLEGEKYFKGKATDGK-----GGKEVDRLIRHIV--GSGHTSTLE------------HLTY----------------------------------------------------------------------------------------------------------------TFAVEG-----------------------------------------------------------------------------------------------------------------------------VSRALLTQL-TRHRVGFSYSVQSQRYVRMGSNDKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGFD------------YVVPETV----------KAKGEH---------------------------------VVKAYNEMMYKLQSDYDLLR--------------------------T-----------------LGIPAEDARSVLP-NAVTTNLVLTVNLRG-LLD-FYNKRRKG--------KGAQAEIAELAEQLRQEV---VKVEKWV-DEFFGSGK------------------------------------------------------------------------------------------------------------------ Bacillus_weihenstephanensis_ZP_01186649 ----------------------------------------------------------------------------------------MDVKLLAHTQLSEEFVNYLSLVSDIGEEGLDPT--------------HGQVVALSAIRTCY-------------SPNKPS--RIVALEGEKYFKGKATDGK-----GGKEVDRLIRHIV--GSGHTSTLE------------HLTY----------------------------------------------------------------------------------------------------------------TFAVEG-----------------------------------------------------------------------------------------------------------------------------VSRALLTQL-TRHRVGFSYSVQSQRYVRMGSDDKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGFD------------YVVPETI----------KAKGEQ---------------------------------VVKAYNEIMYKLQSDYDLLR--------------------------T-----------------LGIPAEDARSVLP-NAATTNLILTVNLRG-LLD-FYNKRRKG--------KGAQAEIAELAEQLRQEV---VKVEKWV-DEFFGSGK------------------------------------------------------------------------------------------------------------------ Bacteriophage_SPM2_CAF34258 --------------------------------------------------------------------------------------MLMSVKLVSVTP-------------------------------------DAEKTIAYIARVSN-------------PNNQ----------------------------ENPNYAKLLSYCI--KHGHWSVFE------------QAHM----------------------------------------------------------------------------------------------------------------TLEIN------------------------------------------------------------------------------------------------------------------------------TSRGIAAQI-LRHRS-FTFQEFSQRYAET---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLLG------------YEIP---------IPDLRSQDHKNRQNSV-DD---ISPEKKSV-------------LQGQIDKHFRESIDLYNELL--------------------------R-----------------QGVAKECARFVLP-LATPTRIYMTGNLRS-WMH-YIDL-RSS--------NGTQKEHMDIAIECKKIF---SEQFPII-NEAWEDK------------------------------------------------------------------------------------------------------------------- Bacteriophage_Syn9_YP_717897 ---------------------------------------------------------------------------------------MTKVCLVSVTP-------------------------------------DAEKTIGYIARVSN-------------PANQ----------------------------ENPKVAGLLKYCI--KHGHWSVFE------------QATM----------------------------------------------------------------------------------------------------------------TLEIE------------------------------------------------------------------------------------------------------------------------------TTRGLAAQI-LRHRS-FCFQEFSQRYADS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLLG------------EKIS---------LPELRLQDHKNRQNSI-DA---IDPWVKQK-------------YEILMQQHFEQGMNLYQQML--------------------------E-----------------DNIAKECARFVLP-LAVGTKLYMTGNLRS-WIH-YINL-RTA--------NGTQKEHMDIAELCKQHF---ICQFPIV-SEALGWCPEGDCGCSQHLDECNCLQPSLRID------------------------------------------------------------------------------------------- Borrelia_afzelii_ABH02196 ---------------------------------------------------------------------------MNK--EYKILDN-GFIKLIDFM--------------------------------------GNDKRIVEAARISY--------------RGDSV---------------------------KRKDEELIDYLI--RNGHTSPLE------------QVVF----------------------------------------------------------------------------------------------------------------TFHVK------------------------------------------------------------------------------------------------------------------------------APIFIARQW-MRHRT-ARINEVSGCYSLA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-EE------------FYVPLEE--------DLKYQISSNSQPKR-EF-----DSLEKK-------------LSDKIKYHQKHSYKLYQDMV--------------------------N-----------------SNIPKELSRIVLP-LSLYTEWYWQIDLNN-LFH-FIKL-RLALDNPKEIKENSPKEMREYAKALISII---KEIVPIS-FNSFENHFLRGKRFSR--EEIIAIVNALDLNKLSM-DAE-KLDL-----LKDKLGID----------------------------------------------------------------- Borrelia_burgdorferi_NP_045749 ---------------------------------------------------------------------------MNK--EYKILDN-GFLKLIDFM--------------------------------------GDDRRIVKAARISY--------------REESV---------------------------KRKDAELIDYLI--RNGHTSPLE------------QVVF----------------------------------------------------------------------------------------------------------------TFHVK------------------------------------------------------------------------------------------------------------------------------APIFVARQW-MRHRT-ARINEVSGCYSLA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-EE------------FYVPLEE--------DLKCQTSSNSSEK--EF-----KSLE-K-------------LSDKIKHHQKHSYELYQDMI--------------------------N-----------------ANIPKELSRIVLP-LSLYTEWYWQIDLNN-LFH-FIKL-RLALDSPKEIKENSPKEMREYAKALISIV---REIVPIA-FNSFENHFLRGKRFSH--EEIIAIINALDLNKLSM-DAE-KLNL-----LKDKLGID----------------------------------------------------------------- Borrelia_hermsii_AAT68707 -----------------------------------------------------------MHDHVKAAEEI-----LDK--EYKVLDK-GFLRLIDYM--------------------------------------GSDERIVNAARVSY--------------RDSKA---------------------------KRDSAGLIDYLI--RNEHTSPLE------------QVVL----------------------------------------------------------------------------------------------------------------TFHVK------------------------------------------------------------------------------------------------------------------------------APIFVARQW-MRHRT-SRINEVSGRYSLM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-EE------------FYVPLRE--------DIKRQSTLNKQGRS-DE--DVEADIALS-------------FLSGLDESYKHSYKIYDDMI--------------------------K-----------------GDVSRELARITLP-LSLYTEWYWQIDLNN-LFR-FIKL-RSS--------GHAQKEIREYAKIILDIV---ELVVPLA-TASFKRHILGGVMLSS--EEVCEIRKVLDLTKINL-PEK-LLNR-----LKEKLNL------------------------------------------------------------------ Brevibacterium_linens_ZP_00380332 -----------------------------------------------------------------------------------MRQVEPSVELLAKPSIDWESMRTYLDEVGGTTWADRVEEADSP---------DAEDLLEFSGRMCY-------------RSWEPGLNPNVSR-------------------VRTDSAQYLGNVI--ASQHGSVLE------------HANF----------------------------------------------------------------------------------------------------------------TFVLHN-----------------------------------------------------------------------------------------------------------------------------VSRVLTHEL-IRHRAGSAFSQESLRYVRL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADIP------------FWFPEWA----------REDSE----------------------------------LMERSLKVLDTLEEHQKWMTEHFELDEASTKFSH------------------------------KKHMTSFMRRFAP-EGLATGIVYTANLRS-LRH-VIEM-RTA--------KGAEEEIRLVFNKIGEAM---REEAPAI-FSDYEVVDGEWIPGTR--KA------------------------------------------------------------------------------------------------------ Caldicellulosiruptor_saccharolyticus_ZP_00884689 --------------------------------------------------------------------------------------MSFKVVLLSHTP-------------------------------------DPEKVVATAAKLCY-------------SNTSVE---------------NIYDKL-----DSEAVKNFLNLLI--DVGHESPLE------------HVSF----------------------------------------------------------------------------------------------------------------TFGIEG-----------------------------------------------------------------------------------------------------------------------------VSRSFTHQL-VRHRI-ASYSQQSQRYVRL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGFD------------YVIPPSI----------EEDQE----------------------------------LKNIFIDTMNEIAKSYRVLTEKLQEKHKRVLISKGLSEKEALKKA-------------------EKMAIEDARYVLP-NACETKIIMTMNARE-LLH-FFNE-RCC--------NRAQWEIRSVADKILEIV---KGIAPNL-FKFAGPKCIKLGYCPE--G-KFSCGEYDKVRQKYLGKREKDEDN------------------------------------------------------------------------------ Campylobacter_coli_ZP_00368146 ----------------------------------------------------------------------------------------MQITLLFH---------------------------------------TPLSVCSHATRTCW-------------QSFDKG-------------------DC-----GGEKDKELIDRVG-NKFKHASTLE------------HLNY----------------------------------------------------------------------------------------------------------------TFYIQG-----------------------------------------------------------------------------------------------------------------------------ISRACLQEV-ARHRH-TSPSVKSTRYTLKELRNEGEF---KIGDFENASRYLVLC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNEEVDNASIQALENLRLIL--------------------------Q-----------------KSISLDIAKYCLP-ESYKTELTLTINARS-LQN-FISL-RSS--------KSALWEIRNLANALFEAL---PQDHQFI-FEHCLHKDIH---------------------------------------------------------------------------------------------------------------- Campylobacter_concisus_ZP_01375100 ------------------------------------------------------------------------------MLKNFTKRENMQVTLLNH---------------------------------------TPLNICSHAIRTCW-------------QSFEKG-------------------DN-----GGEKDVELIDRVG-NKFKHASTLE------------HLYY----------------------------------------------------------------------------------------------------------------NFYIQG-----------------------------------------------------------------------------------------------------------------------------ISRALLQEL-ARHRI-ASLSVKSTRYTLKELKKEEKF---EVGQFERAAKFIVLT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDEMVDNASIKALENLREIL-------------------------AS-----------------TTKSLDIVKYCLP-ECYKTELTWSINARS-LQN-FISL-RSS--------KSALWEIRNLANTIYNAL---PNEHKFI-FEKCLPEDEG---------------------------------------------------------------------------------------------------------------- Campylobacter_curvus_ZP_01376670 ----------------------------------------------------------------------------------------MQVTLLNF---------------------------------------TPLNICSHAIRTCW-------------QSFERG-------------------DN-----GGEKDIELISRVG-NKFKHASTLE------------HLYY----------------------------------------------------------------------------------------------------------------NFYIQG-----------------------------------------------------------------------------------------------------------------------------ISRALLQEL-ARHRV-ASLSVKSTRYTLKELKKEAKF---ELGGFERASDYIVLT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNEMVDNASIKALENLREIL-------------------------AT-----------------TTTSLDIVKYCLP-ECYKTELTWSANARS-LQN-FLSL-RSS--------KSALWEIQKLSHKIYEIL---PQEHKFI-FEDCIAPE------------------------------------------------------------------------------------------------------------------ Campylobacter_fetus_ZP_01411215 ----------------------------------------------------------------------------------------MEVKLLNF---------------------------------------TPLWVCSNAIRTCW-------------QSFDKG-------------------DN-----GGEKDVELIDRVG-NKFKHASTLE------------HLYY----------------------------------------------------------------------------------------------------------------NFYIKG-----------------------------------------------------------------------------------------------------------------------------VSRALLQEL-ARHRI-ASLSVKSTRYTLKELKNESEF---KVGDFESASVYIVLT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNEFVDNASINALENLRRIL--------------------------N-----------------QNTSLDIAKYCLP-ESYKTELSWSINARS-LQN-FLSL-RSS--------KAALWEIRDLANLIYQNL---PDEHKFI-YENCLIKPE----------------------------------------------------------------------------------------------------------------- Campylobacter_jejuni_ZP_01377925 ----------------------------------------------------------------------------------------MQITLLFH---------------------------------------TPLSVCSHATRTCW-------------QSFEKG-------------------DC-----GGEKDKELIDRVG-NKFKHASTLE------------HLNY----------------------------------------------------------------------------------------------------------------TFYIQG-----------------------------------------------------------------------------------------------------------------------------ISRACLQEV-ARHRH-TSPSVKSTRYTLKELRNEAEF---KIGDFENASRYLVLC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNEEVDNASIKALENLRTIL--------------------------Q-----------------KSISLDIAKYCLP-ESYKTELTLTINARS-LQN-FISL-RSS--------KSALWEIRNLANALFEAL---PQEHKFI-FEYCLHKDIE---------------------------------------------------------------------------------------------------------------- Campylobacter_lari_ZP_00369618 ----------------------------------------------------------------------------------------MKITLLNH---------------------------------------TPLSVCSHATRTCW-------------QSFDKG-------------------DC-----GGEKDKELINRVG-NKFKHASTLE------------HLNY----------------------------------------------------------------------------------------------------------------TFYIQG-----------------------------------------------------------------------------------------------------------------------------ISRACLQEV-ARHRH-TSPSVKSTRYTLKELRNESEF---KENDFENAKRYLVLT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNEIVDNASIKALENLRLIL--------------------------Q-----------------NSISLDIAKYCLP-ESYKTELTLTINARS-LQN-FISL-RSS--------KSALWEIRQLANALFENL---PEEHQFI-FKHCVYQEENSQE------------------------------------------------------------------------------------------------------------- Campylobacter_upsaliensis_ZP_00371809 ----------------------------------------------------------------------------------------MRVTLLFH---------------------------------------TPLSVCSHATRTCW-------------QSFEKG-------------------DC-----GGEKDKELIDRVG-NKFKHASTLE------------HLNY----------------------------------------------------------------------------------------------------------------NFYIQE-----------------------------------------------------------------------------------------------------------------------------ISRACLQEL-ARHRH-ASFSVKSTRYTLKELRNEAKF---RENDFENAGRYLVFC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNEAVDNASIKALENLREIL--------------------------Q-----------------TSISLDLAKYCLP-ESYKTELTFSINARS-LQN-FLSL-RSS--------KSALWEIRALARALFEAL---PEEHCFI-FEHCMQD------------------------------------------------------------------------------------------------------------------- Candidatus_Kuenenia_CAJ72160 -----------------------------------------------------------------------------MLYYENMSESKLNVLLLRYTQ-------------------------------------DPEHIVAQAAKLCY-------------SPSSVA---------------ELKEQI-----DSKDQSAFIEKLT--EMGHLSPIE------------HVSF----------------------------------------------------------------------------------------------------------------TFGIEG-----------------------------------------------------------------------------------------------------------------------------ISRACSHQL-VRHRL-ASYSQQSQRYVGKYSKKT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGFD------------FVIPPMI----------EKAG-----------------------------------KKQWFIEKMNCIQEWYDELIEALGDS--------------------------------------GESTFEDARFLLP-NAAETKIIITMNARE-LLH-FFRV-RCC--------NRAQWEIRAMTIEMLRLA---KKVAPNI-LKDAGPGCVN-NACPE--G-KMTCGKMDEVRNMFR-NI------------------------------------------------------------------------------------ Candidatus_Pelagibacter_ZP_01264826 --------------------------------------MKLTKEQSQEIKDQQGQQNQTKRVTAPALENI-----LYE--AMPALDH-GFVRVIDYM--------------------------------------GDDTSIVQSARVSY-------------GKGTKQ---------------------------VSTDAGLIKYLM--RHWHSTPFE------------MCEI----------------------------------------------------------------------------------------------------------------KYHVK------------------------------------------------------------------------------------------------------------------------------LPIFIARQW-IRHRT-ANVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-KE------------FYLPSAE--------NLAAQSSSNRQGR--GD--VIEGEQAKE-------------VLELLKNDAEQTYDNYEMML--------------------------NQRFDGSTIDEN-----KKGLARELARMNLT-LNTYTQWYWKTDLLN-LMN-FLRL-RAD--------SHAQYEIRVYADIMLDTV---KKWVPIT-YDAFMDYRVGGTEVSA--KGKIIIQKLIKGEDVNP-DSS-GLSKREWNELMVSFDLKDKLI------------------------------------------------------------- Candidatus_Protochlamydia_CAF22879 -----------------------------------------------------------M----LTDDYEEFTESQIQTLKRYVTNTSSHVFALRNLPEV-----------------------------------IKGALFSRYSRSSL-GLRSLLLKEFISNNDETAFEDIVGVAFKEEEKQQTHQSE-----AIRKAQAFYDRIL-DGYGDDSIGE------------LGGA----------------------------------------------------------------------------------------------------------------HLAIEN-----------------------------------------------------------------------------------------------------------------------------VSMMAAKLI-EDHRIGGSPLEKSTRYIYFDQKVNGEYLFYR-EPILMTSAYRDSYVQTCNMLFDTYSRLIPPMTAIIEQRFPKDP--------------------SISKTAYTAALRAKVLDCLRGLLPAGTLTNMGIYGNGRFFEHLIHRMNCQNLAELQDIAKRSHQELSKIIPSFVRRSDP-----------------------THRTHQSYAQFLETMQS-----ELRLIAEQYLGKCDRSLQPGVRLVSSDPEAVTKVAAALLFSLGDKGFADIWNQCKRLSDEELARILDAGCNARENRRQKSPRALEHAEFTFEIISDFGAYRDLHRHRILTQERQLLCCDYG----FYIPPEIQNTP---------------------------------------------YEEAYCHALNQAKEVFDLI---------------------------------------------SSELPEEAQYIVP-MAYNIRWYFHVNLRA-LQW-LCEL-RSA--------PAGHPSYRHIAQTMARLT---CEAFPAF-ERFFKFVDYEGYELGR--LDQEQRKIDKQQSLLI---------------------------------------------------------------------------------------- Carboxydothermus_hydrogenoformans_ABB14922 ----------------------------------------------------------------------------------------MKVSLLTYTQ-------------------------------------EPERTVAAAARLCY-------------SPVGVE---------------EILEKM-----DEERQKNFIKKLW--DLNHLSPFE------------HVSF----------------------------------------------------------------------------------------------------------------TFGIEG-----------------------------------------------------------------------------------------------------------------------------VSRALTHQL-VRHRI-ASFSQQSQRYVVE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNFN------------FLIPPTI----------ANSSQ----------------------------------ALEIYQQVLRAIKEGYLKLIE-------------------------------------------MGIPAEDARYLLP-NAAETKIVVTMNARE-LLH-FFEV-RLC--------SRAQHEIRTLARKMLEEV---RKVAPIL-FEKAGPLCETRGVCFE--G-PMSCGRLNLQDEGGS--------------------------------------------------------------------------------------- Chlamydia_muridarum_AAF39712 ----------------------------------------------------------------MLSKEGDFSKEQRERLSHFVTNLDSPIFALKNLPEV-----------------------------------VKGALFSKYSRSIL-GLRALLLKEFLDGEGGDF-----------LSEDLQDCEL-----GIQKAADFYRRVL-DNFGDDSVGE------------LGGA----------------------------------------------------------------------------------------------------------------HLAIEQ-----------------------------------------------------------------------------------------------------------------------------VSMLAAKVL-EDARIGGSPLEKSSRYVYFDQKVNGEYLYYR-DPILMTSAFKDTFLDTCDFLFNTYSELIPQVRAYFEKIYPKDP--------------------EVSQSAYTVSLRAKVLDCLRGLLPAATLTNLGFFGNGRFWQNLLHRLQDNNLVEVRNIGEQALTELMKIIPSFVSRAEP-----------------------HHHHHQAMVDYHLGLRE-----QLKSFAQRYGEEREPSLEKGVKLVYGDPDGLYKIAAASMFPYSEHTYADLLDICRKIPDEDLMLILESSASSRENRRHKSPRGLECAEFAFDITADFGAYRDLQRHRILTQERQLLTTKLG----YSIPQQLLDTP---------------------------------------------MEAPFREAMEKADQAYRLI---------------------------------------------AAEFPEEAQYVVP-LAYNIRWLFHINTRG-LQW-LCEL-RSQ--------PQGHESYRQIAIDMAKEV---IQFHPAY-KSFLKFVDYSETDLGR--LKQESRRKA----------------------------------------------------------------------------------------------- Chlamydia_trachomatis_AAX50909 ----------------------------------------------------------------MLSKEGGFSEEQRARLSHFVTNLDSPIFALKNLPEV-----------------------------------VKGALFSKYSRSTL-GLRALLLKEFLDGEGGNF-----------LDDDQQDCEL-----GIQKAADFYRRVL-DNFGDDSVGE------------LGGA----------------------------------------------------------------------------------------------------------------HLALEQ-----------------------------------------------------------------------------------------------------------------------------VSMLAAKIL-EDARIGGSPLEKSSRYVYFDQKVNGEYLYYR-DPILMTSAFKDVFLDTCDFLFNTYSDLIPQVRSHFEKLYPKDP--------------------EVSQSAYTVSLRAKVLDCLRGLLPAATLTNLGFFGNGRFWQNLLHRLQDNSLVEVRNIGEQSLTELMKIIPSFVSRAES-----------------------HHYHHQAMVDYRRALKE-----QLKSFAHRYGEEREISKEAGVKLVYGDPDGLYKIAAAYMFPYSEHTYAELLDICRNIPNEDLMRILESGASFRENRRHKSPRGLECAEFAFDITADFGAYRDLQRHRILTQERQLLTTKLG----YTMPSQLIDTP---------------------------------------------MEAPFREAMEKADQAYRLI---------------------------------------------AEEFPEEAQYVVP-LAYNIRWLFHINARG-LQW-LCEL-RSQ--------PQGHESYRKIAIDMAREV---IQFHPAY-ELFLKFVDYSETDLGR--LQQESRKKS----------------------------------------------------------------------------------------------- Chlamydophila_abortus_CAH64419 ----------------------------------------------------------------MLSRDDEFSSEQRKSLSHFVTNLETNIFALKNLPEV-----------------------------------VKGALFSKYSRSTL-GLRSLLLKEFLEGEGGDF-----------LDSSSVDFEV-----GIHKAADFYRRVL-DGFGDDSIGE------------LGGA----------------------------------------------------------------------------------------------------------------HLAMES-----------------------------------------------------------------------------------------------------------------------------VSMLAAKIL-EDARIGGSPLEKSSRYVYFDQKVKGEYLYYR-DPILMTSAFKDVFLGTCDFLFDTYADLIPKVRSYFEKIYPKES--------------------EVSQSAYTISLRAKVLDCLRGLLPAATLTNLGFFGNGRFWQTLLHKIQGHNLTEIRQIGESSLTELMKIIPSFVSRAES-----------------------HHHHHQAMLSYRQTLRE-----QLTSLAEKFRGEAQPSKQTGVRLVYGDPEGIYKVAAGFLFPYSEHTYEELIHICKSMPREDLIRVLEAGSSSRENRRHKSPRGLECLEFGFDITADFGAYRDLQRHRILTQERQLLTTNLG----YHIPEQLLDTP---------------------------------------------MEKDFREAMEKAEEAYNQI---------------------------------------------SLEFPEEAQYVVP-LAYNIRWFFHINGRA-LQW-LCEL-RSQ--------VQGHENYRKIAIDMVKEV---VRFDPVY-ESFFKFVDDSECDLGR--IKQESRKRSF---------------------------------------------------------------------------------------------- Chlamydophila_caviae_AAP05750 ----------------------------------------------------------------MLSRDDEFSSEQKRSLSHFVTNLETNIFALKNLPEV-----------------------------------VKGALFSKYSRSTL-GLRSLLLKEFLEGEGGDF-----------LDDSGVDFEV-----GIHKAADFYRRVL-DGFGDDSIGE------------LGGA----------------------------------------------------------------------------------------------------------------HLAMES-----------------------------------------------------------------------------------------------------------------------------VSMLAAKIL-EDARIGGSPLEKSSRYVYFDQKVKGEYLYYR-DPILMTSAFKDVFLGTCDSLFDTYTDLIPKVRAYFEKIYPKEA--------------------EVSQSAYTISLRAKVLDCLRGLLPAATLTNLGFFGNGRFWQTLLHKIQGHNLTEIRQIGENSLTELMKIIPSFVSRAES-----------------------HHHHHQAMLGYRQTLKE-----QLTSLAEKFSEGSSPSKQTGVRLVYGDPEGIYKVAAGFLFPYSEHTFEELINICKAMPKEDLIRVLEAGSSSRENRRHKSPRGLECLEFGFDITADFGAYRDLQRHRILTQERQLLTTKLG----YHIPEQLLDTP---------------------------------------------MEKDFREAMEKAEEAYNQI---------------------------------------------SVEFPEEAQYVVP-LAYNIRWFFHINGRA-LQW-LCEL-RSQ--------IQGHENYRRIAIDMAKEV---INFDPTY-ETFFKFVDYSECDLGR--LKQESRKRSS---------------------------------------------------------------------------------------------- Chlamydophila_felis_YP_514918 ----------------------------------------------------------------MLSRDEEFSSEQKKSLSHFVTNLETNIFALKNLPEV-----------------------------------VKGALFSKYSRSTL-GLRSLLLKEFLKGEGGDF-----------LDDSVVDFEA-----GIHKAADFYRRVL-DGFGDDSIGE------------LGGA----------------------------------------------------------------------------------------------------------------HLAMES-----------------------------------------------------------------------------------------------------------------------------VSMLAAKIL-EDARIGGSPLEKSSRYVYFDQKVKGEYLYYR-DPILMTSAFKDVFLGTCDFLFDTYTDLIPKVRSYFEKIYPKDA--------------------EVSQSAYAISLRAKVLDCLRGLLPAATLTNLGFFGNGRFWQTLLHKLQGHNLTEIRHIGENSLTELMKIIPSFVSRAES-----------------------HHHHHQAMLNYRQTLRE-----QLTSLAEKFSKSSSPSKQTGARLVYGDPEGIYKVAAGFLFPYSEHTYEELINICRSMPREDLIRVLEAGSSSRENRRHKSPRGLECLEFGFDITADFGAYRDLQRHRILTQERQLLTTNLG----YHIPEQLLDTP---------------------------------------------MEKDFREAMEKAEEAYNQI---------------------------------------------SLEFPEEAQYVVP-LAYNIRWFFHINGRA-LQW-LCEL-RSQ--------VQGHENYRKIAIDMAKEV---IRFDPVY-EIFFKFVDYSECDLGR--LKQESRKRSA---------------------------------------------------------------------------------------------- Chlamydophila_pneumoniae_NP_224942 ----------------------------------------------------------------MLGKEEEFTCKQKQCLSHFVTNLTSDVFALKNLPEV-----------------------------------VKGALFSKYSRSVL-GLRALLLKEFLSNEEDGD-----------VCDEAYDFET-----DVQKAADFYQRVL-DNFGDDSVGE------------LGGA----------------------------------------------------------------------------------------------------------------HLAMEN-----------------------------------------------------------------------------------------------------------------------------VSILAAKVL-EDARIGGSPLEKSTRYVYFDQKVRGEYLYYR-DPILMTSAFKDMFLGTCDFLFDTYSALIPQVRAYFEKLYPKDS--------------------KTPASAYATSLRAKVLDCIRGLLPAATLTNLGFFGNGRFWQNLIHKLQGHNLAELRRLGDESLTELMKVIPSFVSRAEP-----------------------HHHHHQAMMQYRRALKE-----QLKGLAEQATFSEEMSSSPSVQLVYGDPDGIYKVAAGFLFPYSNRSLTDLIDYCKKMPHEDLVQILESSVSARENRRHKSPRGLECVEFGFDILADFGAYRDLQRHRTLTQERQLLSTHHG----YNFPVELLDTP---------------------------------------------MEKSYREAMERANETYNEI---------------------------------------------VQEFPEEAQYMVP-MAYNIRWFFHVNARA-LQW-ICEL-RSQ--------PQGHQNYRTIATGLVREV---VKFNPMY-ELFFKFVDYSDIDLGR--LNQEMRKEPTT--------------------------------------------------------------------------------------------- Chlorobium_chlorochromatii_ABB27663 ----------------------------------------------------------------------------------------MNVRLIATTTPAIQIEGQTP---------------------------TPEGLMAYCARVSS-------------PNQ-----------------------------ESLDYEKLLAYCI--RNKHWSVFE------------MVDM----------------------------------------------------------------------------------------------------------------TVEIV------------------------------------------------------------------------------------------------------------------------------TSRAISPQI-LRHKS-FQFQEFSQRYAKV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QEVE-------------------------RYEPRRQDSKNRQNSI-DD---LDESVKVW-------------FMEAQEEIANNAMEYYNMAL--------------------------E-----------------KGIAKECARVLLP-LATQTRLYMKGSVRS-WIH-YLEV-RTS--------SSTQMEHREIALAIQRLF---MEQFPIT-ASALGWKSAAPCP------------------------------------------------------------------------------------------------------------- Chlorobium_ferrooxidans_ZP_01385207 ----------------------------------------------------------------------------------------MQVRLIAVTTPLIQVDNVQL---------------------------TPEGLIAYCARVSS-------------PHQ-----------------------------ETPDYQKLLAYCI--AHKHWSVFE------------MVDM----------------------------------------------------------------------------------------------------------------TVEIV------------------------------------------------------------------------------------------------------------------------------TSRAISPQI-LRHRS-FQFQEFSQRYARA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QEIE-------------------------RYQPRRQDSKNRQNSL-ED---LESETVAW-------------FDAAQERVARLTLEEYDKAL--------------------------E-----------------KGIAKECARVLLP-MATQTKLYMKGSVRS-WIH-YLEV-RTD--------SSTQKEHRDIALAIKKIF---IAQFPVT-AAALGWS------------------------------------------------------------------------------------------------------------------- Chlorobium_limicola_ZP_00511556 ----------------------------------------------------------------------------------------MQVRLIAVTTPCFEAENHPIT--------------------------TAEGLMAYCARVSS-------------PHQ-----------------------------ENLDYEKLLAYCI--ANKHWSIFE------------MADM----------------------------------------------------------------------------------------------------------------TVEIV------------------------------------------------------------------------------------------------------------------------------TSRAIAPQI-LRHRS-FQFQEFSQRYAKA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAVE-------------------------KYLPRRQDSKNRQNSL-DD---LDDRTIAW-------------FNEAQNEIARLSMDRYNDAI--------------------------E-----------------KGIAKECARVLLP-LGTRTKLYMKGSVRS-WIH-YLEV-RTD--------SSTQKEHRDIAAEIKSIF---CTQFPAT-AGALGWM------------------------------------------------------------------------------------------------------------------- Chlorobium_phaeobacteroides_BS1_ZP_00531300 ----------------------------------------------------------------------------------------MKVRLIAVTNPLVEIQNEKL---------------------------SPEGLIAYCARVSS-------------PHQ-----------------------------ENLDYEKLLAYCI--KNRHWSIFE------------MVDM----------------------------------------------------------------------------------------------------------------TVEIV------------------------------------------------------------------------------------------------------------------------------TSRAISPQI-LRHRS-FVFQEFSQRYAKV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNFE-------------------------TCSPRRQDSNNRQHSI-ND---LDASTTRW-------------FTDAQEEIRALSVEKYNEAL--------------------------E-----------------KGIARECARMLLP-LNTQTKLYMKGSVRS-WIH-YIEV-RTD--------AGTQKEHRDIAQEVRDIF---ITQFPVT-ASALGWSASAR--------------------------------------------------------------------------------------------------------------- Chlorobium_phaeobacteroides_ZP_00529968 ----------------------------------------------------------------------------------------MQVRLISATSPLISIDNKPL---------------------------SAEGLMAYCARVSS-------------PHQ-----------------------------ENDSYEKLLAYCL--EHKHWSVFE------------MADM----------------------------------------------------------------------------------------------------------------TVEIV------------------------------------------------------------------------------------------------------------------------------TSRAISPQI-LRHRS-FQFQEFSQRYAKA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAIE-------------------------TYRPRRQDNKNRQNSL-DD---LDPSTCAW-------------FDETQKNIAGLAMEKYNEAL--------------------------E-----------------RGIAKECARVLLP-LATQTKLYMKGSVRS-WIH-YLEI-RTL--------ESTQKEHREIAIEIKHIF---SERFPAV-SKALGWS------------------------------------------------------------------------------------------------------------------- Chlorobium_tepidum_AAM72779 ----------------------------------------------------------------------------------------MQVRLISVTNPLIEIDNRQL---------------------------TPEGLMAYCARVSS-------------PHQ-----------------------------ETPDYEKLLSYCI--QNKHWSVFE------------MVDM----------------------------------------------------------------------------------------------------------------TVEIT------------------------------------------------------------------------------------------------------------------------------TSRAISPQI-LRHRS-FCFQEFSQRYAKA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QTTE-------------------------KYKPRRQDVKNRQNSL-DD---LDEATVKW-------------FDEAQEKIAQLAFESYEEAL--------------------------E-----------------KGIAKECARVLLP-LATQTRLYMKGSIRS-WIH-YLEV-RTD--------PATQKEHRDIAKAVQAIF---VEQFPVT-SKALGWKYGC---------------------------------------------------------------------------------------------------------------- Chloroflexus_aurantiacus_ZP_00768418 -----------------------------------------------------------M----ETQQPETFTEQEIELLQPFVTNVDRPIFCLRNLPEV-----------------------------------VKGALFARYSRSSK-SLRRLLLDEFINEPESGF-----SAMVSAQDHNPAAQLI-----ATRQAEAFYDRVL-IGYGDDSVAE------------LGGA----------------------------------------------------------------------------------------------------------------HLACEG-----------------------------------------------------------------------------------------------------------------------------VSNIAAKLL-EDSRLGISPLEKSTRYVRFDRKGPDGYPYLR-EPAIMASPLADRYVAVMDHLFTTYSELLEPVQAWLQQQYPRDE--------------------ATTPRAYRNTIQAKALDLLRGLLPMATQTNVGLFGNGRAFEYLIIKLAASPFAEAQALSKMIQAELDQVIPSFVKRARS-------------------------DRGQAYADYLATTRE-----QVAALAHQIPVEADSTTPVTVTLVDYDPRAEWKLAAAILYPHLDLPLPAIEELVAAMPEAERHALINAAVGDRANRFHRPGRAFEEPYYTFDILADIGAYRDLQRHRVLTQERQRFTVRHG----YVTPPELEEIG---------------------------------------------VADRYRTALEQAADLVTAL---------------------------------------------EATLPNEAQYAVP-LAFRVRWRIKLNLRE-AYH-LIEL-RSA--------RQGHPSYRQIAQLMFREI---SAVHPFL-AAGMRFVDHNEYDLER--LAAEQRIDQKRQQVGR---------------------------------------------------------------------------------------- Clostridium_perfringens_ABG84971 ---------------------------------------------------------------------------------------MLKVKLLQYTP-------------------------------------EPEKTIAAAAKLCY-------------SPVGVD---------------DILENL-----TDEGAEKFLNMLM--SYGHMSPIE------------HVSF----------------------------------------------------------------------------------------------------------------TFAVEG-----------------------------------------------------------------------------------------------------------------------------VSRSLTHQL-VRHRI-ASYSQQSQRYVKL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DQFE------------YIVPPAI----------ENDEV----------------------------------AKKLFIDQMQGAQKAYDEIVERLKDKY----ISEGIGEKPA-----------------------EKKAIEDARYVFP-NACETKIVFTMNARS-LMN-FFHH-RCC--------DRAQWEIRTMAEKMVNEV---KKVAPIL-FKNAGPSCVA-GPCPE--G-KMCCGKLKEMRTLYLGK------------------------------------------------------------------------------------- Clostridium_sp_ZP_01362803 ------------------------------------------------------------------------------------MESKMKVSLITYTP-------------------------------------EPEKLVAGAAKLCY-------------SPSGIN---------------ELMSNL-----EEGNVEKFIAMLA--IMGHESPFE------------HINF----------------------------------------------------------------------------------------------------------------TFGIEG-----------------------------------------------------------------------------------------------------------------------------VSRSLTHQL-VRHRIGSSYSQKSQRYVNE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGFE------------YIIPPQI----------GGIPE----------------------------------AKALYIKTMENDQLAYDELTNILFEKHYKDYLDKGKNEKAAKSAA-------------------EKQAIEDARYVLP-NSCETKIVVTMNARA-LFN-FFRK-RCC--------NRAQWEIRDLAIEMMKLV---VDVAPNV-FKIAGPGCVT-GKCPE--G-NMSCGEMEAVREKFKSISNR---------------------------------------------------------------------------------- Clostridium_tetani_NP_783134 ---------------------------------------------------------------------------------MRGKTMGVKVKLLEYTP-------------------------------------NPEKVVASAAKLCY-------------SPVGVE---------------EMAKDL-----SEEKVNKFLNMLM--SYGHESPIE------------HVSF----------------------------------------------------------------------------------------------------------------TFAAEG-----------------------------------------------------------------------------------------------------------------------------VSRSLTHQL-VRHRI-ASYSQQSQRYVKL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DQFQ------------YIIPPEI----------DKDNN----------------------------------TRSIFIEAMENSQKAYDKIASTLEQKY----ISEGMKRKEA-----------------------EKKAIEDARYVFP-NACETKIIFTMNART-LMN-FFRH-RCC--------TRAQWEIRNLANEMLSEV---KKVAPNL-FKYSGPSCVN-GNCPE--G-AMSCGKAAEMKKIYL--------------------------------------------------------------------------------------- Corynebacterium_diphtheriae_CAE49993 ----------------------------------------------------------M------------------------AQQSLLDVQLVACSTFTTPSGVDWKVDSAAT---------------------DSEALVEFAGRACY-------------ETFDKP-------------------NP-----RTAANDAYIRHIM--EVGHMALLE------------HPTA----------------------------------------------------------------------------------------------------------------TVYIRG-----------------------------------------------------------------------------------------------------------------------------LSRSATHEL-VRHRH-FSFSQLSQRFVHS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DETH------------VVIPPLI----------DNDPQ----------------------------------LRELFLSTVDEVRFAYSELMTALDNKL-ADEP----------NAILR-----------------RKQARQAARSILP-NATESRIVVTGNFRA-WRH-FIGM-RAT--------EHADVEIRSLAVRCLEIL---KEKAPTV-FSDFETSVLSDGSIMA--TSPYVTDY------------------------------------------------------------------------------------------------ Corynebacterium_efficiens_BAB88822 ----------------------------------------------------------M------------------------TEPVELSVELIACSSFTPPASVAW--DTDAH---------------------GAEALVEFAGRACY-------------ETFDKP-------------------NP-----RTATNAAYLRHIM--EVGHTALLE------------HASA----------------------------------------------------------------------------------------------------------------TMYIRG-----------------------------------------------------------------------------------------------------------------------------ISRSATHEL-VRHRH-FSFSQLSQRFVHE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEQE------------VIIPELI----------NEDPQ----------------------------------LRSLFLRAMDDNRFVYNELLNALEEKL-EGEP----------NALLR-----------------KKQARQAARAVLP-NATESRIVVTGNFRS-WRH-FLGM-RAS--------EHADVEIRAVAVACLEKL---KQQAPTV-FGDFQVETLADGTQMA--TSPYVTDF------------------------------------------------------------------------------------------------ Corynebacterium_glutamicum_CAF20313 ----------------------------------------------------------M------------------------AEQVKLSVELIACSSFTPPADVEW--STDVE---------------------GAEALVEFAGRACY-------------ETFDKP-------------------NP-----RTASNAAYLRHIM--EVGHTALLE------------HANA----------------------------------------------------------------------------------------------------------------TMYIRG-----------------------------------------------------------------------------------------------------------------------------ISRSATHEL-VRHRH-FSFSQLSQRFVHS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GESE------------VVVPTLI----------DEDPQ----------------------------------LRELFMHAMDESRFAFNELLNALEEKL-GDEP----------NALLR-----------------KKQARQAARAVLP-NATESRIVVSGNFRT-WRH-FIGM-RAS--------EHADVEIREVAVECLRKL---QVAAPTV-FGDFEIETLADGSQMA--TSPYVMDF------------------------------------------------------------------------------------------------ Corynebacterium_jeikeium_CAI37294 ----------------------------------------------------------M------------------------ATVAPLQIDLVGHTAFDSVPDLDW--QTDAE---------------------DSAALVEFAGRACY-------------ETWDKP-------------------NP-----HTATNAAYIRHIM--DVGHTTLLE------------HASA----------------------------------------------------------------------------------------------------------------SMYLRG-----------------------------------------------------------------------------------------------------------------------------VSRSCSHEI-MRHRH-FSFSQLSQRYVPA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEAR------------VVVPEAV----------AGNED----------------------------------LKKLFLQAADVAYDAYREILDGLGEDF-AEEP----------NAVLR-----------------TKQARQAARAVLP-NCIETRFVMSGNFRS-WRH-FIAM-RAA--------EHADPEIRRIAVACLREL---QKVAPNV-FEDFSITQLHDGGEMA--TSPYVGES------------------------------------------------------------------------------------------------ Cyanophage_PSSM2_YP_214554 ----------------------------------------------------------------------------------------MDVKFVSITP-------------------------------------DAEKMMAYIARVSN-------------PSNQ----------------------------QNENYSGLLKYCI--KHNHWSVFE------------QSSM----------------------------------------------------------------------------------------------------------------TLEIE------------------------------------------------------------------------------------------------------------------------------TTRGLAAQI-LRHRS-FTFQEFSQRYADT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLLD------------TEIP---------VPDLRSQDLKNRQNSN-DD---IPQEKKEE-------------YQALIARHFEDSMNLYNALL--------------------------S-----------------EGVAKECARFVLP-LATPTRLYMTGSCRS-WIH-YINL-RSA--------HGTQREHMDVVEKARSIF---TEQFPSV-SEALGWV------------------------------------------------------------------------------------------------------------------- Cyanophage_PSSM4_YP_214756 ----------------------------------------------------------------------------------------MKVTKVSVTP-------------------------------------DAEKLIGYIARVSN-------------PKNQ----------------------------ENPEVAGLLRYCI--KHGHWSIFE------------QASM----------------------------------------------------------------------------------------------------------------TVEIE------------------------------------------------------------------------------------------------------------------------------TTRGIAAQI-LRHRS-FTFQEFSQRYADT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLLA------------DEIP---------MFDLRHQDTKNRQNST-DD---VPYNKKKD-------------LEYKIAEHFVEAMDLYNELL--------------------------G-----------------NGIAKECARFVLP-LATPTRLYMTGTVRS-WIH-YIQL-RGG--------HGTQKEHMDIAHAIEDIF---IKEFPIT-SEALEF-------------------------------------------------------------------------------------------------------------------- Dehalococcoides_ethenogenes_AAW39323 ------------------------------------------------------------------------------------MEYNVEVKLLAITP-------------------------------------DAENLAEQAGRLCY-------------ASGNKL----------------------------GSSQDWLQTRI--KQGHESLLE------------HVSA----------------------------------------------------------------------------------------------------------------TFYIK------------------------------------------------------------------------------------------------------------------------------ASRVVTHEL-VRHRI-GSYSQRSQRYVKE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQAE------------FITPPEI----------TEGDSA---------------------------------KLALFNQAMESAWDSYRKLLE-------------------------------------------AGIKPEIARYVLP-NACATEIICTWNFRE-LRH-ILKL-RTA--------PSAQPEMRVVANLIQEIL---KKEAPKI-FGDL---------------------------------------------------------------------------------------------------------------------- Dehalococcoides_sp_ZP_01138669 ------------------------------------------------------------------------------------MEYNVEVKLLAITP-------------------------------------DAENLAEQAGRLCY-------------ASGNKL----------------------------GSSQDWLQTRI--KQGHESLLE------------HVSA----------------------------------------------------------------------------------------------------------------TFYIK------------------------------------------------------------------------------------------------------------------------------ASRVVTHEL-VRHRI-GSYSQRSQRYVKE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQAE------------FITPPEI----------TEGDSA---------------------------------KLALFNQAMESAWDSYRKLLE-------------------------------------------AGIKPEIARYVLP-NACATEIICTWNFRE-LRH-ILKL-RTA--------PSAQPEMRVVANRIQEIL---KKEAPKI-FGDL---------------------------------------------------------------------------------------------------------------------- Deinococcus_geothermalis_YP_605490 ----------------------------------------------------------------------MTAPETAPQILYPLGDPIGSVALVQWA--------------------------------------GDDKMIVNAARVSF-------------GGDTKAP-------------------------LNDRDEKLIRYLL--RHGHGSPFE------------HNLI----------------------------------------------------------------------------------------------------------------TFKIV------------------------------------------------------------------------------------------------------------------------------CPIFVDRQL-VRHRVGVSKNEISGRYVEL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AERN-------------FTPPAF----------RKQAPSNRQASV-EDDGTLDQAA----------------AAQVWAAAWQHAYQAYQDLL--------------------------A-----------------LGVTREQARGVLP-LSLYTESYYTFNVRS-LLH-LLEL-RDH--------AGAQWETRRYARALAELA---EPLFPVT-FREWRALRGG---------------------------------------------------------------------------------------------------------------- Desulfitobacterium_hafniense_YP_516682 ----------------------------------------------------------------------------------------MNVELIQYTP-------------------------------------DPEKVIAAAARLCY-------------SPDPVP---------------ELMEKL-----DEEKVANLVQKLR--AMGHLSTFE------------HISF----------------------------------------------------------------------------------------------------------------QFSIDG-----------------------------------------------------------------------------------------------------------------------------VSRALSHQL-VRHRI-ASYSQRSQRYVKE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGFD------------FVTPPTI----------RRNPQ----------------------------------TQERFENIMATLQEEYQALL--------------------------------------------AMVPAEDARYILP-NACTTSLMATFNARS-LLN-FFEH-RTC--------MRAQWEIRILAEKMLELV---REVAPNV-FGQAGPTCVTQGVCHE--G-AMSCGRIKALKKEAERMTLIYDR------------------------------------------------------------------------------- Desulfotalea_psychrophila_CAG36957 ----------------------------------------------------------------------------------------MYMLIVDPSYEILGEMDSA----------------------------SLVERVEACGRICY-------------KSEDKI--------------------------TPASAIPFVQKMV--VHGHNSVME------------MAAI----------------------------------------------------------------------------------------------------------------TLRFECGTE---------------AVADFFACQPKYFAV----NVVDGGLLVSGSIRAFREFYSLYSENPIICSALVLLAEKEPYLFSDIWGADASY-SGDVKASKLSLAEVDALPAALLLAHRFVAVRFVVNRAVTHEL-VRHRP-CSYLQESQRYCRYSNEKFG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQVS------------FVRPLFF----------EEGTP----------------------------------EYEAWNEAMEETEKLYLQLL--------------------------------------------KTSTPQAARTVLP-NSCKTEIIAFCSLSE-WGH-IFSL-RTT--------THVEPSMREVMIPLEVEM---KGQFPALDY------------------------------------------------------------------------------------------------------------------------- Desulfotomaculum_reducens_ZP_01150252 -----------------------------------------------------------------------------------MGKASLKVRLLEHTP-------------------------------------NPEKVVAMAARLCY-------------SPSDID---------------SLAENV-----STTDQHSFIKKLM--DLGHYSTIE------------HVTF----------------------------------------------------------------------------------------------------------------TFGIEG-----------------------------------------------------------------------------------------------------------------------------VSRSLLAQI-TRHRI-ASFSVQSQRYVGETRSQNNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTFG------------YIIPETI---------LGLGPE----------------------------------AVAEFEEQMAQIQAWYDRWVEKLGS---------------------------------------GRGAYEDARFVLP-NAAETKIVVTMNARE-LRH-FFSL-RCC--------QRAQWEIRALADEMLRLA---KEVAPLL-FADAGPECLV-GPCPE--G-KMSCGKRMEIRKKYGVDS------------------------------------------------------------------------------------ Desulfovibrio_desulfuricans_ABB39118 -----------------------------------------------------------------------------------MPSKECRVELLAHTP-------------------------------------EPLSLIYAAFRQCY-------------HAGFAG---------------DMWQRLVAGDIDRQKQADFISQVL--ESGHASPIE------------HVSF----------------------------------------------------------------------------------------------------------------TFAVEG-----------------------------------------------------------------------------------------------------------------------------VSRALTHQL-VRHRL-ASYSQQSQRYVDG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNFE------------YILPPAI----------ARNQA----------------------------------ARARFEAFMAEVGSAYRDLKQILEQDGRK-----------------------------------GAKANEDARFVLP-QAAESKIVLTMNCRV-LLH-FFEE-RCC--------SRAQWEIRHMADMMLERC---RGALPVI-FRHAGAKCVRLGYCPE--GERFTCGRYPLRDAGRGQP------------------------------------------------------------------------------------- Desulfovibrio_vulgaris_AAS96727 -----------------------------------------------------------------------------------MPRTEPRVELLAHTP-------------------------------------EPLSLLYAAFRQCY-------------HAGFVA---------------DMWPRLLSGEIEREKQGAFIASIL--ESGHSSPIE------------HVSF----------------------------------------------------------------------------------------------------------------TFAIEG-----------------------------------------------------------------------------------------------------------------------------VSRALTHQL-VRHRI-ASFSQQSQRYVDG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHFD------------YVMPPAI----------ARNAA----------------------------------AKARFEQFMEDVGSAYRDIKALLEQDGRT-----------------------------------GSRANEDARFVLP-QAAASKIVVTMNCRA-LVH-FFEE-RCC--------MRAQWEIRAVADVMLGLC---REVLPEL-FAHAGAKCERLGYCPE--GERFTCGRYPLRQSMP---------------------------------------------------------------------------------------- Desulfuromonas_acetoxidans_ZP_01311759 ----------------------------------------------------------------------------------------MDVQLLSHTP-------------------------------------EPEKIVAAAARLCY-------------SDAGIN---------------DLLSA------DRDQQLRLIEKIL--KLGHFSVLE------------HVSF----------------------------------------------------------------------------------------------------------------SFGLEG-----------------------------------------------------------------------------------------------------------------------------LSRACSHQL-VRHRV-ASYSQQSQRYVAHD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPFA------------AVEPPSL----------ADHPE----------------------------------LQQRYHDLFDQVHHLYKDMLE-------------------------------------------AGVPAEDARFVLP-NAAQTKLVMTMNARE-LHH-FFSL-RCC--------RRAQWEIRAMAKQMLLLC---RDAAPVL-FAQAGPGCLR-GACPE--G-AMCCGEADAVRQEYGQN------------------------------------------------------------------------------------- Dictyostelium_discoideum_XP_641335 --------------------------------------MGLD--IQTEIDKIVIEKVKPEVEYYDVMGGS-----HRW--EVKVHDH-GKVALVDTMPRLAPVGQ------------------------------TADFSICQAARVSY-------------GAGTKK---------------------------VTEDKGLIRYLY--RHQHTSPFE------------MVEF----------------------------------------------------------------------------------------------------------------KFHCV------------------------------------------------------------------------------------------------------------------------------MPVFIARQW-IRHRT-ANVNEYSARYSVL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-DK------------FYHPSIE--------EVRKQSTSNRQGG--EE--ALEPKTAQE-------------FLDYLDK-VEENYKTYNELL--------------------------E-----------------KGLSRELGRIGLP-VSIYTEWYWKIDLHN-LFH-FLRL-RMD--------SHSQKEIRDYANTIFALI---RPIVPVA-CEAFIDYAFESLKLTR--LEIEAIRTGSPLNTTNK-------REIEEFEEKKKLLFPNTQA------------------------------------------------------------- Ehrlichia_canis_AAZ68718 ---------------------------------------------MGGVMMELMESKLTKRVVVPELEEI-----LYK--EHKVLDK-GFVRLVDYM--------------------------------------GSDESVVQSARISY-------------GRGTKS---------------------------VNQDAALINYLM--RHSHTTPFE------------MCEI----------------------------------------------------------------------------------------------------------------KFHIK------------------------------------------------------------------------------------------------------------------------------LPIFVARQW-VRHRT-ANVNEYSARYSVL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-RE------------FYIPEHD--------QIAKQSENNAQGR--GS--SLSHEDAEY-------------VTDLLVHDSNMVYETYNKFL--------------------------E-----------------KGISREISRVNLT-LNYYTEWYWKIDLHN-LLH-FLKL-RSE--------MNAQYEIRVYAKAILEIV---KKWVPLT-YAAFVEYSLESQHLSK--SALDVVRRLIAGEEVAR-EDT-SIGKREWKELMSILENEL---------------------------------------------------------------- Ehrlichia_chaffeensis_ZP_00544975 -----------------------------------------------------MESAVTKRIVVPELEEI-----LYK--EYKVLDK-GFVRLIDYM--------------------------------------GSDESIVQAARISY-------------GRGTKS---------------------------VSQDAALINYLM--RHSHTTPFE------------MCEI----------------------------------------------------------------------------------------------------------------KFHIK------------------------------------------------------------------------------------------------------------------------------LPIFVARQW-VRHRT-ANVNEYSARYSVL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-HE------------FYIPEHS--------QVAMQSEDNAQGR--GN--NLSDEDAKY-------------VADLLTRDSDMVYETYNKFW--------------------------E-----------------KGVSKEIARVNLT-LNYYTEWYWKIDLHN-LLH-FLKL-RSE--------MTAQYEIRVYAETMLDMV---KKWVPLT-YAALVEYGLKSQNFSR--SALDVVKKLMVGEKVVQ-EDT-NIGKREWRELMAILKPE----------------------------------------------------------------- Ehrlichia_ruminantium_CAI27208 ----------------------------------------MLVLSIRIKVWQTMESEITKRIVVPELEDI-----LYK--EHKVLDK-GFVRLVDYM--------------------------------------GSDESVVQAARISY-------------GRGTKS---------------------------VSQDAALINYLM--RHSHTTPFE------------MCEI----------------------------------------------------------------------------------------------------------------KFHIK------------------------------------------------------------------------------------------------------------------------------LPIFVARQW-VRHRT-ANVNEYSARYSVL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-HE------------FYIPELD--------HVATQSEDNAQGR--GN--SLSNEDAQY-------------VTDLLKRDSDMVYETYNKFL--------------------------I-----------------KGVSREISRISLT-LNYYTEWYWKIDLHN-LLH-FLRL-RSD--------VHAQYEIRVYAETMLEIV---KKWVPLT-YAAFVEYCLESQSFSK--SALSVVKKLIAGEDVAR-EDT-GIGKREWRELMDVLADNK---------------------------------------------------------------- Ferroplasma_acidarmanus_EAM93455 -----------------------------------------------------------M-------HRYIFIHRTDTIFMDDFSNNDRDVFLIKTD-MI-----------------------------------DRGALMSRYSRTANLDIREVYGKEFKNNPD--------------------------------RASNFYKRIF-LDYGDESVAE------------LTTA----------------------------------------------------------------------------------------------------------------QMGIQN-----------------------------------------------------------------------------------------------------------------------------VSNIVTKVI-EEPRIGLSYLEKSSRYVKYNKKVNGNYLFLRGENAGV-GAMESRYNSYCNDLFDFYSAAYPEMMKYMEDANPIENFTFEIGGKNYKYTNLESVDENTLSKSYKSSLRSAVLDEIRALLPASTLTNIGISGNGRAFISLIERLKAYGTPEAEKYGELIYRELEPELPELIEDAVS----------------------AHGIAQIKYNNAKDS-------------IGNSFSNDTANVPALKVINFMDEKRAIDLATGMLLYGSSAGSSNV-----DIPPEKQYSILKELESLRGNRRHKLGRAFEGITYSFEVNMNYGAFREFQRHRFFSIIRKPLSTQYG----YDIPENLGKIPE--------------------------------------------LRSRYVELMDEARILYNDIM--------------------------------------------GRSGRKIAQYVVP-YAYKYPVVFSSNLNE-LTY-FIEL-RSN--------QQVHPDLRKVALDIYSEI---KKIHPHL-ATLIKFVDTGDYRLGR--LPSEVKKESRRKTLSGEND------------------------------------------------------------------------------------- Frankia_alni_YP_715896 ----------------------------------------------------------M----------------PAAAPTG-PATARLRVQVIAKTEFLPPADVPW--STDAD---------------------GGQALAEFAGRACY-------------QSWSKP-------------------NP-----ATATNAGYLRHIL--DVGHLSVLE------------HGTV----------------------------------------------------------------------------------------------------------------SLYLTG-----------------------------------------------------------------------------------------------------------------------------VSRSLTHEL-VRHRH-FSYSQLSQRYVPE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDAA------------IVEPEVV----------AGDPE----------------------------------LHALFEQAAAASLEAYGRLLEGLEKRF-ADIA----------APTSR-----------------RKQARQAARSVLL-NATETRIVVTGNYRA-WRH-FIAM-RAS--------EHADVEIRGLAVAILREL---HAVAPNV-FSDFRISTLDDGTEVA--SSPLVGEG------------------------------------------------------------------------------------------------ Frankia_sp_EAN1pec_ZP_00571881 ----------------------------------------------------------MVEVGVPDEIDETAGLEQLDEPSPGPVAARMKVQVIARTEFLPPDDVPW--STDAE---------------------GGQALAEFAGRACY-------------QSWNKP-------------------NP-----ATATNAGYLRHIL--DVGHLSVLE------------HGTV----------------------------------------------------------------------------------------------------------------SLYITG-----------------------------------------------------------------------------------------------------------------------------VSRSLTHEL-VRHRH-FSYSQLSQRYVPE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HDAA------------VVEPEVI----------ASDPE----------------------------------LHALFTEAAAASMDAYARLLEGLEKRF-ADVS----------APTSR-----------------RKQARQAARSALM-NATETRIVVTGNYRA-WRH-FIAM-RAS--------EHADVEIRGLAIAALRAL---RDVAPNV-FADFRVTTLDDGTEVA--SSPLVGEG------------------------------------------------------------------------------------------------ Frankia_sp_YP_482628 ----------------------------------------------------------MM---------EVAVSQPTSEPTSEPTSVRLRVQVIAKTEFIPPDDVAW--STDAD---------------------GGQALAEFAGRACY-------------QSWNKP-------------------NP-----ATATNAGYLRHIL--DVGHLSVLE------------HGTV----------------------------------------------------------------------------------------------------------------SLYLTG-----------------------------------------------------------------------------------------------------------------------------VSRSLTHEL-VRHRH-FSYSQLSQRYVPE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDAA------------VVEPEVI----------AADPE----------------------------------LHALFQQAAAASLEAYGRLLEGLEKRF-ADVS----------APISR-----------------RKQARQAARSVLM-NATETRIVVTGNYRA-WRH-FIGM-RAS--------EHADVEIRGLAVAVLREL---LRVAPNV-FADFRISTLDDGTEVA--SSPLVGEG------------------------------------------------------------------------------------------------ Geobacter_metallireducens_ABB30621 ----------------------------------------------------------------------------------------MKVTLLQHTP-------------------------------------DPEMAVALAARLCY-------------SPIGID---------------ELKERL-----SRSDISAFLDKIM--SLGHQSVLE------------HASF----------------------------------------------------------------------------------------------------------------TFGIEG-----------------------------------------------------------------------------------------------------------------------------ISRATSHQL-VRHRI-ASYSQQSQRYVTHT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQFS------------AVIPPSI----------AGRPD----------------------------------LAARFRSQLKALHDTYAELFE-------------------------------------------AGIPAEDARYILP-NAAETKIIMTMNARE-LLH-FFGL-RCC--------ERAQWEIRAMAVEMLRLV---KGVAPTI-FRDAGPGCVA-GPCPE--G-TMTCGKIVEVRKRFK-EMYV---------------------------------------------------------------------------------- Geobacter_sp_ZP_01389528 ----------------------------------------------------------------------------------------MKVALLQHTP-------------------------------------DPELTVALAARLCY-------------SKVGID---------------ELKQKL-----TSSDIDSFLDKIM--SLGHQSVLE------------HASF----------------------------------------------------------------------------------------------------------------TFGIEG-----------------------------------------------------------------------------------------------------------------------------ISRVTSHQL-VRHRV-ASYSQQSQRYVSHK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQFA------------VVVPPEI----------AKNPE----------------------------------MLEMFQEQMGQLHECYARMVD-------------------------------------------GGIPAEDARYLLP-NATETKIVVTMNARE-LLH-FFAV-RCC--------ERAQWEIRAMSVEMLRLV---RDIAPII-FRNAGPGCLG-GPCPE--G-KMTCGRAQEIREKFH-NL------------------------------------------------------------------------------------ Geobacter_sulfurreducens_AAR36497 ----------------------------------------------------------------------------------------MKIALLQHTP-------------------------------------DPEAAVALAARLCY-------------ASVGID---------------ELREKL-----SASDVTAFLDKIM--SLGHQSVLE------------HASF----------------------------------------------------------------------------------------------------------------TFGIEG-----------------------------------------------------------------------------------------------------------------------------ISRAASHQL-VRHRI-ASYSQQSQRYVTFRG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGFP------------RVVPGSV----------SATEK----------------------------------RRQVFESAMQACADAYRALVD-------------------------------------------DGVPAEDARFVLP-NAAETKIIVTMNARE-LIH-FFGL-RCC--------ERAQWEIRALAVEMLRLV---KGVAPTI-FRDAGPGCLT-GPCPE--G-GMTCGKAAEVKRLFR-EMSI---------------------------------------------------------------------------------- Geobacter_uraniumreducens_ZP_01142218 ----------------------------------------------------------------------------------------MKVALLQHTP-------------------------------------DPEMTVALAARLCY-------------SPVAID---------------ELKQRL-----SGADIRTFLDKIM--SLGHQSVLE------------HASF----------------------------------------------------------------------------------------------------------------TFGIEG-----------------------------------------------------------------------------------------------------------------------------ISRVTSHQL-VRHRV-ASYSQQSQRYVSHK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERFA------------AVIPPTI----------GERPD----------------------------------VLARFEAQLQALHQAYAEMVE-------------------------------------------AGIPAEDARYILP-NATETKIMVTMNARE-LLH-FFAV-RCC--------ERAQWEIRAMSLEMLKLV---KGIAPTI-FRDAGPGCLS-GPCPE--G-TMTCGKIVAVREFFR-NF------------------------------------------------------------------------------------ Gloeobacter_violaceus_BAC90262 --------------------------------------------------------------MTNAHTLKLKDIAGKDPGVIRVLDQ-GFIQLVDYMPSDYPFGQVVEGAT------------------------AGDIAIVAAARVSY-------------GTVTKG---------------------------TDADRKLIEFLL--RHGHTSPLE------------MVEF----------------------------------------------------------------------------------------------------------------KFIVK------------------------------------------------------------------------------------------------------------------------------APVVMWWQH-VRHRI-QEMNFQSGRYTPY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PENE------------FYLPEKL----------RAQDKVNKQGSVLVD--FLSSDEERA-------------LLEELRAHYEAGFSLYKKML--------------------------A-----------------KGVAKEMARLALPGWALYHTAYVKMNAHA-LMH-YLAK-RTE--------PDAQYEIRVYAQAMERIF---AEKLPWV-HDTWRNSRGAAM-------------------------------------------------------------------------------------------------------------- Gluconobacter_oxydans_AAW61178 --------------------------------------MALTSEQRAEIEAQRSEPQLTSRPTVAAMENL-----LFT--PFEVLDH-GFLRVVDYM--------------------------------------GDDGAVVQAARVSY-------------GRGTKK---------------------------VSEDAGLIRYLM--RHRHSTPFE------------MCEI----------------------------------------------------------------------------------------------------------------KFHVK------------------------------------------------------------------------------------------------------------------------------LPVFVARQW-IRHRM-ASVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-RE------------FYLPAMD--------QVAAQSSSNRQGR--SD--ALDADTAHQ-------------VLEILRRDASQCYDDYESLL--------------------------NPE--------------GRGLARELARINLT-LNTYTQWYWKIDLHN-LMH-FLAL-RAD--------PHAQYEIRVYAEKMIEIL---KAWVPAT-AAAFEEYRLGAFTLSA--GMLKVVRRRLAGETVTQ-ENS-GLTKREWSEMAAVLDGAS---------------------------------------------------------------- Haloarcula_marismortui_AAV46077 ----------------------------------------------------------------------------------------MDVKLLEATD-------------------------------------DPEDLICKAARNDY-------------SDTSVGSQSFEA------TMAEVDGDS-----LEEKKETLIGHLL--DHGHFGPFE------------HAQA----------------------------------------------------------------------------------------------------------------TFAVEG-----------------------------------------------------------------------------------------------------------------------------VSRSCMAQI-TRHRH-VSFDVQSMRYVSF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDVDPEAVREGE----LVVTPPS----------ATDP--DWIGRN-QQKASVSDEEFEE-------------RAEIFKDTIEQAVESYQELLE-------------------------------------------LGMPPEDARFVLP-IGTKVNIVMSMNARM-LMH-VADM-RAA--------ADAQWEIREMTEEMLELA---ADWCPKT-FEYYEQEMKGRKNRLA--P------------------------------------------------------------------------------------------------------- Halobacterium_salinarum_AAK00648 ----------------------------------------------------------------------------------------MRVRLLEATE-------------------------------------NPEELICQSARNDY-------------MSDWVGDTPLDT------AMASVDGDT-----TDEKLSNLIAQLL--TRGHYGPFE------------HPSA----------------------------------------------------------------------------------------------------------------TFAIEG-----------------------------------------------------------------------------------------------------------------------------VSRSCMAQL-TRHRH-ASFDVQSMRYVAF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDVDPAAVAEGE----LVVTPPS----------ATDP--DWVGRN-QDAGDIDEETMAE-------------RQAVFQASVRRAVEDYQELLG-------------------------------------------LGMPPVDARFVLP-IGTEVNVVITLNPRS-LMH-VADM-RAA--------ADAQWEIRELTEQLLDAA---AQWCPHT-FEYYDAEMKHRKNRLA--P------------------------------------------------------------------------------------------------------- Halobacterium_sp_AAG19665 ---------------------------------------------------------------------MVPARGFGVFLPPAGTPSSMRVRLLEATE-------------------------------------NPEELICQSARNDY-------------MSDWVGDTPLDT------AMASVDGDT-----TDEKLSNLIAQLL--TRGHYGPFE------------HPSA----------------------------------------------------------------------------------------------------------------TFAIEG-----------------------------------------------------------------------------------------------------------------------------VSRSCMAQL-TRHRH-ASFDVQSMRYVAF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDVDPAAVAEGE----LVVTPPS----------ATDP--DWVGRN-QDAGDIDEETMAE-------------REAVFQASVRRAVEDYQELLG-------------------------------------------LGMPPEDARFVLP-IGTEVNVVITLNPRS-LMH-VADM-RAA--------ADAQWEIRELTEQLLDAA---AQWCPHT-FEYYDAEMKHRKNRLA--P------------------------------------------------------------------------------------------------------- Halovirus_HF1_AAO61355 ----------------------------------------------------------------------------------------MKVELKTEYSTQ-----------------------------------NPDDVPVMAARGDY-------------MSESLVGKNIED-----------ALAG-----TPKTHEALMGELL--RRGHFGPFE------------HIQA----------------------------------------------------------------------------------------------------------------FFAVEG-----------------------------------------------------------------------------------------------------------------------------LSRSAMAQV-TRHRH-MSFDVQSQRYCDF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDKN------------IVIPPGD----------KKNPAAEDVVLG-QYDGPAEDFT----------------GADALEGHFVNSVELYEKLIE-------------------------------------------QGMAKEDARFVLP-IGVEVDMTFSANART-LMH-FFDL-RKN--------MKAQWEAREFATKVLEEC---KEWSPLV-FNAYEEHLNNNSIRAP---------------------------------------------------------------------------------------------------------- Helicobacter_acinonychis_YP_665477 ----------------------------------------------------------------------------------------MEVICKHH---------------------------------------TPLDIASQAIRTCW-------------QSFEYS-------------------DD-----GGCKDKALIHRVG-NIFRHSSTLE------------HLYY----------------------------------------------------------------------------------------------------------------NFEIKG-----------------------------------------------------------------------------------------------------------------------------LSRGALQEL-SRHRI-ASLSVKSSRYTLRELKEVESFLPLNETNLARAEEFLVFV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNEKVNEMSVLALENLRVLL-------------------------NE-----------------HNIKNDLAKYAMP-ESYKTHLAYSINARS-LQN-LLTL-RSS--------NKALKEMQDLAKALFDAL---PCEHQYL-FEDCLKR------------------------------------------------------------------------------------------------------------------- Helicobacter_hepaticus_AAP77717 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MG-NKFKHASTLE------------HLYY----------------------------------------------------------------------------------------------------------------NFYIKG-----------------------------------------------------------------------------------------------------------------------------ISRACLQEL-ARHRL-ASYSVKSSRYTLKELKNLPSFLPVNDENLARAEQFVVFT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNKEVDIASLKALENLREIL--------------------------C-----------------NNVSNDVAKFAMP-ESYRTELSFSINARS-LQN-FLSL-RTS--------KSALWEIRALAFSIFNAL---PEEHRFI-FQDCVQEC------------------------------------------------------------------------------------------------------------------ Helicobacter_pylori_NP_208323 -----------------------------------------------------------------MWITQETWLKALPWNKKRYRSQIMEVICKHY---------------------------------------TPLDIASQAIRTCW-------------QSFEYS-------------------DD-----GGCKDKELIHRVG-NIFRHSSTLE------------HLYY----------------------------------------------------------------------------------------------------------------NFEIKG-----------------------------------------------------------------------------------------------------------------------------LSRGALQEL-SRHRI-ASLSVKSSRYTLRELKEVESFLPLNETNLERAKEFLVFV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNEKVNAMSVLALENLRILL-------------------------SE-----------------HNIKNDLAKYAMP-ESYKTHLAYSINARS-LQN-FLTL-RSS--------NKALKEMQDLAKALFDAL---PGEHQYL-FEDCLKH------------------------------------------------------------------------------------------------------------------- Herpetosiphon_aurantiacus_ZP_01426098 ---------------------------------------------------------------MHDPWGDTFTADEQAILAPFVTNLDQPIFGLRNLPEV-----------------------------------VKGALFSRYSRSDK-SLRRMLLDEFIQAPEAGF-----QAIVGHAAANGNDQLV-----ATKQAEAFYERVL-LGYGDDSVAE------------LGGA----------------------------------------------------------------------------------------------------------------HVACEG-----------------------------------------------------------------------------------------------------------------------------VSNIVAKAL-EDSRLGLDPLEKSTRYVPFDRQVAGKYRYHR-VAELMQSPHATLYEQTLDQLFDTYRVLIEPVQRWVQSATPRDA--------------------KTSERAYVSATRAKALDLLRGLLPMATLTNVGLFGNGRAFEYLLTKLASSEHSEVCNVGVNLQHELDQLIPSFVKRAKT-------------------------ERGAAYSQYLATMRQ-----AGAAFQPEIPTSNDL---QAVTLVEFDPDAEAKVVAAILYPHSDQPLETLQCWARNLPTEERSAIIRAYVGERGSRFHRPGRAFEETYYTFDFLADIGAYRDLQRHRILTQERQRYSVVHG----YAVAPELEAAG---------------------------------------------VAAAYCTALDQTAAAVQAI---------------------------------------------EADFPAAAQYLVP-FAYRIRWRFRLNLRE-AYH-LIEL-RAA--------PQGHPSYRAIAQQMYLAL---QKIHPSL-IEGMQFVDLGEHALER--LAAEQRFDQKLAERQQ---------------------------------------------------------------------------------------- Jannaschia_sp_YP_509033 ---------------MWPLAARPNRFRSIRTF-----VMPLTPEQLEDIQNSRANPQPTLRAVAPGMEQH-----LYE--AKPVLDH-GFVRVIDYM--------------------------------------GDDAAIVQAARVSY-------------GAGTKK---------------------------ARDDSGLIRYLM--RHWHSTPFE------------MCEL----------------------------------------------------------------------------------------------------------------KLHVK------------------------------------------------------------------------------------------------------------------------------LPVFVARQW-IRHRT-ANVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-RE------------FYIPQPD--------QLAAQSVVNNQGR--GE--TLQGEEAER-------------VLRMLKDDAGRAYDHYEEML--------------------------SQ--------EG-----QQGLARELARMNLP-ANVYTQWYWKVDLHN-LFH-FLRL-RAD--------EHAQYEIRVYADAICEMV---KDWVPAA-YGAFEDYRMGGVQLSG--KGVEVLRRRLAGEEVTQ-ETS-GMSKGEWREFEAVF-------------------------------------------------------------------- Lawsonia_intracellularis_YP_595563 -----------------------------------------------------------------------------------MPGVTPRVELLSYTP-------------------------------------EPLSVIYASFRQCY-------------HAGFVG---------------DMWKKLLDGEIPKEKQASFIHSLI--ESGHTSPIE------------HVSF----------------------------------------------------------------------------------------------------------------TFAISG-----------------------------------------------------------------------------------------------------------------------------VSRALTHQL-IRHRL-ASYSQQSQRYVDG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKFE------------YIVPPSI----------AKDPK----------------------------------ALEKFTELMERIGEDYRELKALLESGKR------------------------------------TASSIEDARFVLP-QAAATNIVMTMNCRA-LLN-FFEH-RCC--------FRAQWEIRNVAYMMLKHC---RMIIPAI-FDPAGAKCERLQYCPE--GEKYTCGLYPVR-------------------------------------------------------------------------------------------- Leptospira_interrogans_NP_711714 --------------------------------------------------------------------------------------------MITSE--------------------------------------KSIEIRDKVAKSTK------------------------------------------------------------KAGHLTTRQ------------HPQF----------------------------------------------------------------------------------------------------------------IFTLDK-----------------------------------------------------------------------------------------------------------------------------VSRQFVWSFLHSHPF-YNSEQVSQRYVEVKKENYYI-------PPELDGKLLELYLDAVDFASQSYFSYTEALHPFIQEEYFQIY-----------------KARANYPDKWQTPIKKKCLEVARYLLPLGTFTYLYHSVNGLTLHRYYRLMNSYDVPNEQRAVITEMINQVRAIDPLYADEMDDPVPLEETTEYRYFDSMFGNGKREFHPETASTFVKEFDLELGERYSKLVSHSSNGPEILAQSVRSILGIPKSILNDQDAIDLVLNPAKNRHLTSTLNESSMSP---------------------ITRALFNVQYSFQKRISHTADSQDQRHRMVPGGRPVLMSQYAGIPDYITPFVVQKYPE--------------------------------------------LKEKYDVVHREIFEKLNRFLE-------------------------------------------AGGSPEHGTYLLP-NSFPIRFYESGDLLN-LHH-KWRS-RTC--------YNAQEEIFQASVDELTDV---MKVHPQI-AKWIKAPCWIRLQGEV--KPYCPEGDHYCGTQVWKRELSEYSRVI----------------------------------------------------------------------------- Magnetococcus_sp_EAN29948 MAAAHEGLWCRIGRFSLFINTNLYVSPFGGNLLSFSPPNLSSYAKRVLTVMEASTGTAFQSEPTLEMAAEIETRLQLNPDYTKRIGNFGFLELEESW--------------------------------------GDEATIINTARIST-------------TNKRVN-----------------SLDA-----FTDKERTLLHYLL--AHNHGTPFE------------TVHF----------------------------------------------------------------------------------------------------------------RFRVV------------------------------------------------------------------------------------------------------------------------------APIFVLRQW-MRHRI-CSFNEFSQRYRM----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PITA------------FYVPDQE-ARTVDGFEVLSQESVER-------------------------------YCELVESMHRFYHDEYQQVC-----TRIEAAEQAGLVEKTAGSRNPY-----------------RARARELLRNAMP-VSTYSDLYWTINFRA-LMN-FFEL-RRK--------ANAQYEIRAYADAAYEMF---CKKMPLL-GETMNRVLEERAKMGE--QA------------------------------------------------------------------------------------------------------ Moorella_thermoacetica_YP_431307 ------------------------------------------------------------------------------------------MIIEQPRVLVPEKALDA----------------------------NLILRLERYARVCY-------------KSEART--------------------------GADTAAPFLKKLL--ERGHESVIE------------HEKI----------------------------------------------------------------------------------------------------------------TVLII------------------------------------------------------------------------------------------------------------------------------ADRGISHEI-VRHRI-GSYSQESTRYCNYSKDSFG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEIT------------VIEPFFF-----------AGRE----------------------------------AYNLWEKACRVAEKSYLELL--------------------------------------------KYSSPQEARSVLP-NSLKTELVVTYNLRE-WRH-FFRL-RCS--------SSAHPQMRQIAIPLLLLF---RKRLPVL-FEDINYDQNFPGKYYA--RVIITDDFFHEIGREEL--------------------------------------------------------------------------------------- Mycobacteria_phage_AAC18488 ----------------------------------------------------------------------------------------MKVQLIASTILEDPSWAGTDYVGDDETVT------------------SADELAEFAGRNCY-------------LSFDRP-------------------NP-----KTRENVDYLNHIL--DVGHESVLE------------HSSA----------------------------------------------------------------------------------------------------------------TFYIE------------------------------------------------------------------------------------------------------------------------------ASRSVLTEL-ERHRH-LSFSVVSQRYVDP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TELG------------IHVPPAFTEL---SGSDADK------------------------------------AKEVLLDVQSFAQEAYEYLVHIFS------------------DAGFP-----------------RKKAREAARAVLP-NMTNSPMVVTGNHRA-WRY-VIKN-RWH--------EAADAEIRELAGELLRQL---REIAPNT-YQDIPTEPYSYGG------------------------------------------------------------------------------------------------------------- Mycobacteriophage_Catera_YP_656098 -------------------------------------------------------------------------------MLDIQFTDEIVVEVLDSN--------------------------------------FSDSRVCVAARTST-------------AGAGAD---------------------------DSERYGLINALM--RDRHGTPFE------------HMNA----------------------------------------------------------------------------------------------------------------TFRVT------------------------------------------------------------------------------------------------------------------------------APIFVWREH-HRHRSGWSYNEESGRYKQL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPV-------------FYVPGET----------RPIAKVEGTRNMDYVLEKGTADQHAL-------------IANAMWATCSGAYRQYEAML--------------------------D-----------------AGIVREVARMVLP-VNIMSTCIVTCNARS-LMH-FLSL-RQRHDDARFP-SKPQYEINLVANGYERLL---AEEAPLV-HRSYVENGRVAP-------------------------------------------------------------------------------------------------------------- Mycobacteriophage_Che12_YP_655630 ----------------------------------------------------------------------------------------MKVQLIASTILEDEGWAGTGYT-DSDTTT------------------SADELAEFAGRNCY-------------RSFTRP-------------------NP-----KTRANVDYLDHIL--DVGHESVLE------------HSSA----------------------------------------------------------------------------------------------------------------TFYIE------------------------------------------------------------------------------------------------------------------------------ASRSVLTEL-ERHRH-LSFSVVSQRYVDP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TELG------------IEVPPAFTEL---AGKDADD------------------------------------AKGVLLDVQSFTQEAYEYLVHIFT------------------EAGKP-----------------RKQAREAARAVLP-NMTSSPMVVSGNHRA-WRY-VIKN-RWH--------EAADAEIRELAGELLTQL---REIAPNT-YQDIPTTPYSYGG------------------------------------------------------------------------------------------------------------- Mycobacterium_avium_NP_961799 ----------------------------------------------------------M------------------------AEIAPLRVQLIAKTDFLAPPDVPW--STDAD---------------------GGPALVEFAGRACY-------------QSWSKP-------------------NP-----KTATNAGYIKHII--DVGHFSVLE------------HASV----------------------------------------------------------------------------------------------------------------SFYITG-----------------------------------------------------------------------------------------------------------------------------ISRSCTHEL-IRHRH-FSYSQLSQRYVPE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDSR------------VVVPPGL----------DDDPE----------------------------------LQQILAAAADASRATYTELLARLEAKF-ADQP----------SAVLR-----------------RKQARQAARAVLP-NATETRIVVTGNYRA-WRH-FIAM-RAS--------EHADVEIRRLAIECLRRL---ADVAPAV-FADFEIATLADGTEVA--TSPLATEA------------------------------------------------------------------------------------------------ Mycobacterium_bovis_CAD94960 ----------------------------------------------------------M------------------------AETAPLRVQLIAKTDFLAPPDVPW--TTDAD---------------------GGPALVEFAGRACY-------------QSWSKP-------------------NP-----KTATNAGYLRHII--DVGHFSVLE------------HASV----------------------------------------------------------------------------------------------------------------SFYITG-----------------------------------------------------------------------------------------------------------------------------ISRSCTHEL-IRHRH-FSYSQLSQRYVPE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDSR------------VVVPPGM----------EDDAD----------------------------------LRHILTEAADAARATYSELLAKLEAKF-ADQP----------NAILR-----------------RKQARQAARAVLP-NATETRIVVTGNYRA-WRH-FIAM-RAS--------EHADVEIRRLAIECLRQL---AAVAPAV-FADFEVTTLADGTEVA--TSPLATEA------------------------------------------------------------------------------------------------ Mycobacterium_flavescens_ZP_01194553 ----------------------------------------------------------M------------------------AEIAPLRVQLIAKTEFSAPPDVEW--STDAD---------------------GGAALVEFAGRACY-------------QSWSKP-------------------NP-----RTATNATYVRHII--DVGHFSVLE------------HASV----------------------------------------------------------------------------------------------------------------SFYITG-----------------------------------------------------------------------------------------------------------------------------LSRSCTHEL-IRHRH-FSYSQLSQRYVPE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDAE------------VVAPPGI----------EDDPE----------------------------------LLALFTAATDASRAAYTELLNRLEAKL-ADQG----------TSTLR-----------------RKQARQAARAVLP-NATETRIVVTGNYRA-WRH-FIAM-RAS--------EHADVEIRRLAIECLRRL---VAVAPQV-FSDFEITALADGTEVA--TSPLATEV------------------------------------------------------------------------------------------------ Mycobacterium_leprae_CAC30465 ----------------------------------------------------------M------------------------AQIAPLRVQLIAKTEFLAPPDVSW--TTDAD---------------------GGSALVEFAGRACY-------------QSWSKP-------------------NP-----RTATNAAYIKHII--DVGHVAVLE------------HASV----------------------------------------------------------------------------------------------------------------SFYISG-----------------------------------------------------------------------------------------------------------------------------ISRSCTHEL-IRHRH-FSYSQLSQRYVPE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDAQ------------VVVPPDM----------EDDDE----------------------------------LQQILIAAVEASRATYTELLVKLNAKLMAGELGGN-------RAVLR-----------------RKQARQAAHAVLP-NANETRIVVTGNYRA-WRH-FIAM-RAS--------EHADVEIRRLAIVCLRRL---VDVAPAV-FADFEITALADGTEVA--TSPLATEA------------------------------------------------------------------------------------------------ Mycobacterium_phage_Bxz1_NP_818164 -------------------------------------------------------------------------------MLDIQFTDEIVVEVLDSN--------------------------------------FSDSRVCVAARTST-------------AGAGAD---------------------------DSERYGLINALM--RDRHGTPFE------------HMNA----------------------------------------------------------------------------------------------------------------TFRVT------------------------------------------------------------------------------------------------------------------------------APIFVWREH-HRHRSGWSYNEESGRYKQL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPV-------------FYVPGET----------RPIAKVEGTRNMDYVLEKGTADQHAL-------------IANAMWATCSGAYRQYEAML--------------------------D-----------------AGIVREVARMVLP-VNIMSTCIVTCNARS-LMH-FLSL-RQRHNDARFP-SKPQYEINLVANGYERLL---AEEAPLV-HRSYVENGRVAP-------------------------------------------------------------------------------------------------------------- Mycobacterium_phage_L5_CAA79424 ----------------------------------------------------------------------------------------MKAKLIAATEIDPGALRDIGFEVDDFEESKDEDPYFGDF--------DADELAEFAGRNCY-------------RSFHRP-------------------NP-----ATAENEDYLNHII--DLGHESVFE------------HASA----------------------------------------------------------------------------------------------------------------TFYIE------------------------------------------------------------------------------------------------------------------------------ASRSVLTEL-ERHRH-LSFSVVSQRYVDP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDLG------------IHLPPALFKL---HPDDRDD------------------------------------LVHIMESVSSEIDAVYEHIVNRLA------------------DRGLP-----------------RKQAREAARAVLP-NMTNSPMVVTGNHRA-WRY-VIKA-RWH--------EAADAEIRELAGELLRQL---RQIAPNT-YQDIPDVPYSY--------------------------------------------------------------------------------------------------------------- Mycobacterium_phage_NP_817637 ----------------------------------------------------------------------------------------MKVQLIASTVLEDPYWAGTGYT-DSGTPS------------------SADELAEFAGRNCY-------------RSFSRP-------------------NP-----GTRENVDYLKHIL--DVGHESVLE------------HASA----------------------------------------------------------------------------------------------------------------TFYIE------------------------------------------------------------------------------------------------------------------------------ASRSVLTEL-ERHRH-LSFSVVSQRYVDP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TELG------------VHEPPAVKDLIDAPGRGYFR------------------------------------AKELLEEIQHASAEAYDELVTIYA------------------EAGLG-----------------RKKAREAARAVLP-NMTNSPMVVTGNHRA-WRY-VIKA-RWH--------EAADAEIRSLAGELLRQL---REIAPHT-YQDIPDTPYSY--------------------------------------------------------------------------------------------------------------- Mycobacterium_sp_YP_639279 ----------------------------------------------------------M------------------------AETAPLRVQLIARTEFTVPPDVPW--ETDAE---------------------GGAALVEFAGRACY-------------QSWSKP-------------------NP-----RTATNASYLRHII--DVGHLSVLE------------HASV----------------------------------------------------------------------------------------------------------------SFYITG-----------------------------------------------------------------------------------------------------------------------------ISRSCTHEL-IRHRH-FSYSQLSQRYVPE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDSQ------------VVVPPGI----------EGDAE----------------------------------LEGLFTAAADASRAAYAELLAKLEAKLMGDEPREG-------RATLR-----------------RKQARQAARSVLP-NATETRIVVTGNYRA-WRH-FIAM-RAS--------EHADLEIRRLAIACLREL---VAVAPAV-FADFEIYPLADGTEVA--TTPLVTEA------------------------------------------------------------------------------------------------ Mycobacterium_tuberculosis_ZP_00770421 -------------------------------------------------------MSAV------------------------AETAPLRVQLIAKTDFLAPPDVPW--TTDAD---------------------GGPALVEFAGRACY-------------QSWSKP-------------------NP-----KTATNAGYLRHII--DVGHFSVLE------------HASV----------------------------------------------------------------------------------------------------------------SFYITG-----------------------------------------------------------------------------------------------------------------------------ISRSCTHEL-IRHRH-FSYSQLSQRYVPE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDSR------------VVVPPGM----------EDDAD----------------------------------LRHILTEAADAARATYSELLAKLEAKF-ADQP----------NAILR-----------------RKQARQAARAVLP-NATETRIVVTGNYRA-WRH-FIAM-RAS--------EHADVEIRRLAIECLRQL---AAVAPAV-FADFEVTTLADGTEVA--TSPLATEA------------------------------------------------------------------------------------------------ Mycobacterium_vanbaalenii_ZP_01208056 ----------------------------------------------------------M------------------------AEIAPLRVQLIAKTEFSAPPDVPW--STDAD---------------------GGAALVEFAGRACY-------------QSWDKP-------------------NP-----RTATNAGYVRHII--DVGHFSVLE------------HASV----------------------------------------------------------------------------------------------------------------SFYITG-----------------------------------------------------------------------------------------------------------------------------ISRSCTHEL-IRHRH-FSYSQLSQRYVPE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HDSQ------------VVAPPGI----------EDDPE----------------------------------LLEIFTEAADAGRAAYTELLTRLEARL-ADQP----------NATLR-----------------RKQARQAARAVLP-NATETRIVVTGNYRA-WRH-FIAM-RAS--------EHADLEIRRLAIECLRQL---VDAAPQV-FSDFEIVVLADGTEVA--TSPLATEV------------------------------------------------------------------------------------------------ Nanoarchaeum_equitans_AAR38870 ----------------------------------------------------------------------------------------MRITVIDYFK-------------------------------------DIEDIIGITAKSTQ-------------SLFPPS-----------------ELEI-----DQKDIDDMLKYTV--EHKLSSVLD------------FPYY----------------------------------------------------------------------------------------------------------------IIEIYG-----------------------------------------------------------------------------------------------------------------------------VSRSFTHQW-VRHRL-SSHMQQSLRYVKIIDEKVLELYESD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRIDLITYVPKW----FVIPPSI--------LISGKE-----------------------------------AIIKYIEAMINSSKAYLELL-------NYKIPEGNSFNHWF-LTKNR-----------------EYIPKEDARFALP-IGTKTFVTTAADAEE-WLH-IMKV-RCC--------MDAQWEIRITAWTIGFLL---YLLHPRI-FYRFGPWCIQERCRGF--SIKRDPTCIKNIFNLKETLKEISNKIREHFINREDGEIETPLGRIKFYIENKKWDFFTIDLTDIFGYRTSEEIKKEVIDYFESQGIKLDKNLLDFEVIGRIRYI Neorickettsia_sennetsu_YP_506060 -------------------------------------------------MVDKENLNKTKRVVSESLEEK-----LGE--SYQVFNS-GFVRVVDYM--------------------------------------GNDQAIVQAARVSY-------------GKGTKT---------------------------VNQDRGLIHYLM--RHGHTTPFE------------MCEI----------------------------------------------------------------------------------------------------------------KFHVK------------------------------------------------------------------------------------------------------------------------------MPIFVARQW-IRHRT-ANVNEYSARYSIV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-EE------------FYIPEID--------KVCYQSATNSQGR--GD--RLEQEFAQE-------------FRHFLIESNSATYDEYTRFI--------------------------E-----------------TGLAREIARIAMP-LNTYTEMYWKVDLHN-LFH-FLKL-RSH--------QGAQYEIRKYAEVIEEIV---GSWVPMA-YEAFLEYVKHAKTLSR--SAIKYVRDNLKGELSSE-REKYGIGMREFTEVTEILSGTEEG-------------------------------------------------------------- Nostoc_punctiforme_ZP_00106512 -------------------------------------------------------------------------------------MHRFRVEVIAKTP-------------------------------------NPQQVIYAAMHQDY-------------TDGFVF-------------DERDSWPS-----ESQSGEVIVKRLLAGERGHYGPLE------------HPQI----------------------------------------------------------------------------------------------------------------VFNCGY-----------------------------------------------------------------------------------------------------------------------------FPHSVMQQA-RTHRVGVSFDVQSFRYTGNQFIDVLEGKKDI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDVF------------YLRPVGY-----------------------------------YTDRQGKKYHYSPEQRAADLEWCLEAAKRYQADFE-------------------------------------------GGMSEEHARGKVP-FDYRQHFVVSFNLRS-FLH-FCDL-RNK--------KDAQLEIQKLCEMMWPHF---EDWAPAI-AQWYEKQRLGKARLAP---------------------------------------------------------------------------------------------------------- Nostoc_sp_BAB72473 -------------------------------------------------------------------------------------MDRFRVEVIAKTP-------------------------------------NPQQVIYAAMHQDY-------------TDGFVF-------------DERDSWPS-----ESECGDIIIKRLLAGERGHYGPLE------------HPQI----------------------------------------------------------------------------------------------------------------VFNCGY-----------------------------------------------------------------------------------------------------------------------------FPHSVMQQA-RTHRVSVSFDVQSFRYTGNQFIDVVEGIKDI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDVF------------YLRPVGY-----------------------------------YTDRQGKKYYYSPEQRAADLQWCLEAAKRYKADFE-------------------------------------------GGMSEEHARGKVP-FDYRQHFVVSFNLRS-FLH-FCDL-RNK--------KDAQLEIQKLCELMWPHF---AEWSPAI-AQWYEKARLGRARLSP---------------------------------------------------------------------------------------------------------- Oceanicola_granulosus_ZP_01156549 --------------------------------------MTLTPEQQAEIDELRATPRPTLRAVSEGMEGH-----LYK--ANPVLDH-GFVRVIDYM--------------------------------------GDDAAICQAARVSY-------------GRGTKA---------------------------VSNDEGLIRYLM--RHWHSTPFE------------MCEV----------------------------------------------------------------------------------------------------------------KLHVK------------------------------------------------------------------------------------------------------------------------------LPVFVARQW-IRHRT-ANVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-RE------------FYIPEPE--------KLAAQSVTNNQGR--GE--ALGPEEGAR-------------VLEWLKADAARAYDHYEAMI--------------------------GQ--------DG-----QQGLARELARMNLP-ANIYTQWYWKVDLHN-LFH-FLRL-RAD--------AHAQYEIRVYAEEICRLV---KDWVPHA-YAAFEDYRLGGATLSG--KALECLRRMLAGEAVTQ-ETS-GMSKGEWREFQAVLG------------------------------------------------------------------- Paracoccus_denitrificans_ZP_00633170 -----------------------------MAIPSEDSAMPITPEQQAQIDEQRADPRPTLRAVSEGMERH-----LYR--AHEVLDH-GLVRVIDYM--------------------------------------GDDAAITQAARVSY-------------GRGTKS---------------------------VSNDEGLIRYLM--RHWHSTPFE------------MCEV----------------------------------------------------------------------------------------------------------------KFHVK------------------------------------------------------------------------------------------------------------------------------LPVFVARQW-IRHRT-ANVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-RE------------FYIPAPE--------HLAAQSTVNNQGR--GQ--VLEGDEAAR-------------VLDLLREDAMRSYDHYEQML--------------------------SQ--------EG-----QQGLARELARMNLP-ANIYTQWYWKVDLHN-LFH-FLRL-RAD--------AHAQYEIRAYAETMCGIV---RDWVPFA-YAAFEDYRLGGVQLSA--KGVEALKRRLSGEVVTQ-ENS-GMSKGEWREFEAVWD------------------------------------------------------------------- Paramecium_bursaria_2CFA_B ----------------------------------------------------------------------------------------MSAKLISVTKPVVEGVN------------------------------TAEELIAYAARVSN-------------PENQI---------------------------NNKTASGLLKYCI--RHKHWSIFE------------TAFM----------------------------------------------------------------------------------------------------------------TLELK------------------------------------------------------------------------------------------------------------------------------TSRGIAAQV-IRHRS-FHFQEFSQRYASV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------METPP--------PHQARFQDHKNRQNSL-DT---VPEDDQTW-------------WATEQEKLYAQSMELYNKAL--------------------------E-----------------KGIAKECARFILP-LSTPTTIYMSGTIRD-WIH-YIEL-RTS--------NGTQREHIDLANACKEIF---IKEFPSI-AKALDWVH------------------------------------------------------------------------------------------------------------------ Pelobacter_carbinolicus_YP_358099 ----------------------------------------------------------------------------------------MLVQLLTHTP-------------------------------------EPERLVAAAARLCY-------------SASSVE---------------ELLQQ------DSARREALLAKIL--SVGHLSTLE------------HVSF----------------------------------------------------------------------------------------------------------------TFGIEG-----------------------------------------------------------------------------------------------------------------------------VSRACSHQL-VRHRL-ASYSQQSQRYVSHK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QRFT------------AVTPPSI----------ADRPE----------------------------------LLATFEAALEEMHRVYAELME-------------------------------------------AGIPAEDARFVLP-NAAETKLVMTMNARE-LLH-FFAL-RCC--------RRAQWEIRALAVEMLRQV---RGVAPGL-FAAGGPGCLV-GACPE--G-AMTCGCVDEVRKEFA-NL------------------------------------------------------------------------------------ Pelodictyon_luteolum_ABB23254 --------------------------------------------------MPELEGTGCRCIFRFLNHS---------------SRPPMQVRLIALTAPQINIEGQSL---------------------------TAEGLMAYCARVSS-------------PHQ-----------------------------ESADYEKLLAYCI--AHKHWSIFE------------MADM----------------------------------------------------------------------------------------------------------------TVEIV------------------------------------------------------------------------------------------------------------------------------TSRAISPQI-LRHRS-FTFQEFSMRYSKA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAIE-------------------------RYTPRRQDSKNRQNSL-DD---LPPETVAW-------------FDEAQERVATESMALYEAAL--------------------------E-----------------KGIAKECARAMLP-LATQTKLYMKGSIRS-WIH-YLEV-RTD--------PATQKEHRDIALEIRKIF---VERFPVT-ASALGWS------------------------------------------------------------------------------------------------------------------- Pelodictyon_phaeoclathratiforme_ZP_00588145 -----------------------------------------------------MNLLILYCLLSKKTTK---------------PLRNMQVRLISVTSPLIKVEGQPL---------------------------SPEGLIAYCARVSS-------------PHQ-----------------------------ETPDYEKLLAYCI--AHKHWSVFE------------MVDM----------------------------------------------------------------------------------------------------------------TVEIV------------------------------------------------------------------------------------------------------------------------------TSRAISPQI-LRHRS-FQFQEFSQRYAKA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QEIE-------------------------RYQPRRQDSKNRQHSL-ND---LDEATKEW-------------FDKAQERVAQMTLETYNEAL--------------------------E-----------------KGIAKECARVLLP-MATQTKLYMKGSVRS-WIH-YLEV-RTD--------KSTQQEHQEIALAIKKIF---MEQFPVT-ATALAWR------------------------------------------------------------------------------------------------------------------- Pelotomaculum_thermopropionicum_GAA00501 -----------------------------------------------------------------------------------MGARKMAVTLLRYTP-------------------------------------DPQEIIAMGAKLCY-------------SPAGIE---------------ELKHGI-----EGKNQAPFLEKLL--DSGHLSPVE------------HASF----------------------------------------------------------------------------------------------------------------TFGIEG-----------------------------------------------------------------------------------------------------------------------------VSRSLLAQL-TRHRI-ASYSVKSQRFVPETGAAEED--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVFG------------YIIPPRI---------EALGRE----------------------------------YVEIFKSQMAQIQKWYDFWREKLGG---------------------------------------GESSNEDARFVLP-NAAETKVLVTMNARE-LLH-FFSL-RCC--------NRAQWEIRALAVEMLRLV---RAVAPVI-FKDAGPGCVR-GSCHE--G-RMSCGRAQEVRERFK-NL------------------------------------------------------------------------------------ Physarum_polycephalum_AAY87038 --------------------------------------IPHTSMATVDISHIKINKVPAETELHDVMSGA-----SRW--DVSIHEH-GSVSLVDVMPRLAPVGQ------------------------------TADFAIVQAARVSY-------------GAGTKK---------------------------VSEDTGLIRYLL--RHQHTTPFE------------MVEF----------------------------------------------------------------------------------------------------------------KFHCV------------------------------------------------------------------------------------------------------------------------------MPMFIARQW-IRHRT-ANVNEYSARYSVV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-DR------------FYHPSIA--------EVRKQSTLNRQGG--DE--VMDEQTAAE-------------FLEYLDA-TEAHYAKYELLL--------------------------N-----------------KGVSRELARIGLP-VSCYTEW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Picrophilus_torridus_AAT43321 -----------------------------------------------------------M----------------------DFSNYDRDVFLIKTDKMI-----------------------------------DRGALMSRYSRTASLDIRDLYKKEF-NDPE--------------------------------RAGDFYRRIF-IEYGDESISE------------LVTA----------------------------------------------------------------------------------------------------------------QMGIQN-----------------------------------------------------------------------------------------------------------------------------ISNIASKII-EEQRIGLSYLEKSSRYVRYDKKTSDGYLYLKPDRAGI-GYKSNEYENICNSLFDFYSSIYNEMLDYFKEKYPVESFTFEIGDSYYKYSDINNLDDNIINKSYKSALRAAVLDEIRYVLPASTLTNLGISGNGRAFISMIQRLYRYNLQETKGLAESIYNELRPEMPGLIDDAFS----------------------KHGYESIEYKKCRYP-------------V--DLYKRYSDLNEVSLISYNSEDEEIKKASRLMMYNSSGSYDSI-----E-----YNDLIDDLYIKRKNRRDKLGRAFESINYLFEVNTNYGAFRELQRHRFLSIIRKPLSVYYN----YDIPENISEVES--------------------------------------------IKKDYISLMDEARDVYNKIL--------------------------------------------ESNGYLIAQYVVP-FAYKYPVVFSANLNE-LAY-MIEL-RTT--------PQAHPDLRRISIKMYNEL---KRVHPRL-SKLIKFVDVNDYHLGR--LPSEFKKEIKRNDVR----------------------------------------------------------------------------------------- Prochlorococcus_marinus_ZP_01006033 ---------------------------------------------------------------------------------------MNSVHLVTATP-------------------------------------DAEKTMAYIARVSN-------------PKNQ----------------------------DNEDFTKLLRYCI--KHEHWSVFE------------QAFM----------------------------------------------------------------------------------------------------------------TIQIE------------------------------------------------------------------------------------------------------------------------------TNRGIAAQI-LRHRS-FTFQEFSQRYADS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQLG-------------QIP---------VPELRRQDNKNRQNSI-HD---LPEEITAR-------------FKIKIKKQFEDSLNLYQEML--------------------------E-----------------SGIAKECARFILP-LATPTRIYMSGSCRS-WIH-YINL-RSG--------YGTQKEHMEIANACKTIF---SQQFPIV-AKALDW-------------------------------------------------------------------------------------------------------------------- Prochlorococcus_marinus_str_MIT_9312_ABB49306 ---------------------------------------------------------------------------------------MSKVELISLTP-------------------------------------DAEKTMAYIARVSN-------------PKNQ----------------------------KNEDYSKLLSYCI--KNEHWSVFE------------QSFM----------------------------------------------------------------------------------------------------------------TLQIE------------------------------------------------------------------------------------------------------------------------------TNRGIAAQI-LRHRS-FTFQEFSQRYADS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SQLG-------------NIP---------LPELRRQDFKNRQNSI-PD---LSDELKKR-------------FNAKIASHFKAASELYEDLL--------------------------S-----------------EGIAKECARFVLP-LSTPTRIYMSGSCRS-WIH-YINL-RSA--------HGTQEEHKSIAQNCKSIF---KDSFPIV-SKSLDW-------------------------------------------------------------------------------------------------------------------- Prochlorococcus_marinus_str_MIT_9313_NP_895377 ---------------------------------------------------------------------------------------MNSVSLISVTP-------------------------------------KAEEIIAYCARVSN-------------PQNQ----------------------------DNPDSERLIRYLI--KHRHWSPFE------------MAHI----------------------------------------------------------------------------------------------------------------VMEIG------------------------------------------------------------------------------------------------------------------------------TTRAIAAQI-LRHRS-FSFQEFSQRYADV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STMA------------FAKP----------PSLRRQDIKNRQSSI-DD---LDQETVSK-------------LSSKANLLFEQSRDLYQEML--------------------------A-----------------AGVAKECAREVLP-LATPTKIYMAGSVRS-WLH-YIDL-RSA--------HGTQKEHQDVAIKCREIL---TKEMPCV-CNAMWP-------------------------------------------------------------------------------------------------------------------- Prochlorococcus_marinus_str_NATL2A_YP_292800 ---------------------------------------------------------------------------------------MSSVQLITSTP-------------------------------------NAEKSMAYIARVSN-------------PKNQ----------------------------DNDDFTKLIGYCI--KNEHWSVFE------------QAYM----------------------------------------------------------------------------------------------------------------TLQIE------------------------------------------------------------------------------------------------------------------------------TTRGIAAQI-LRHRS-FTFQEFSQRYADS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQLG-------------EIP---------IPELRRQDNKNRQNSI-SD---LPKEIINT-------------FNKKIKHQFVQNKELYEEML--------------------------E-----------------AGIAKECARFVLP-LATPTRIYMTGSCRS-WIH-YINL-RTG--------HGTQKEHMEIAQECKNIF---SKEYPVV-SSALNWLF------------------------------------------------------------------------------------------------------------------ Prochlorococcus_marinus_subsp_marinus_str_CCMP1375_NP_874667 ---------------------------------------------------------------------------------------MNNVHLVTATP-------------------------------------DAEKTMAYIARVSN-------------PKNQ----------------------------ANEEFGKLIKYCI--NNEHWSVFE------------QAYM----------------------------------------------------------------------------------------------------------------TLQIE------------------------------------------------------------------------------------------------------------------------------TNRAIAAQI-LRHRS-FTFQEFSQRYADS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TQLG-------------EIP---------IPELRRQDSKNRQNST-SD---LDEDIAND-------------FREKIKLQFKNSLDLYQEML--------------------------D-----------------KGVAKESARFILP-LATPTRIYMTGSCRS-WLH-YINL-RSG--------HGTQKEHLIIAKECKKIF---TLQFPKV-SEALGWIES----------------------------------------------------------------------------------------------------------------- Prochlorococcus_marinus_subsp_pastoris_str_CCMP1986_NP_892362 ---------------------------------------------------------------------------------------MSKVELISLTP-------------------------------------EAEKTMAYIARVSN-------------PSNQ----------------------------ANDKFAGLLRYCI--KHEHWSVFE------------QSCM----------------------------------------------------------------------------------------------------------------TLKIE------------------------------------------------------------------------------------------------------------------------------TNRGIAAQI-LRHRS-FTFQEFSQRYAET---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLLG------------NEIP---------IPNLRRQDQKNRQNSI-DD---IPDELKIK-------------FSEKISKHFQEANKLYEEML--------------------------N-----------------EGIAKECARFIMP-LATPTRIYMTGSCRS-WIH-YIQL-RSK--------EGTQKEHMEIAEDCKKVF---IKYFPSV-SEALNWE------------------------------------------------------------------------------------------------------------------- Prosthecochloris_aestuarii_ZP_00590908 ----------------------------------------------------------------------------------------MNVRLISVTNPLIEIDNERL---------------------------DPEGLIAYCARVSS-------------PQQ-----------------------------DKPDYRNLLQYCI--RNRHWSIFE------------MVDM----------------------------------------------------------------------------------------------------------------TVEIV------------------------------------------------------------------------------------------------------------------------------TSRAISPQI-LRHKS-FCFQEFSQRYSKV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAFE-------------------------TYEPRRQDKQNRQNSI-DD---LDDPTVGW-------------FLKAQNDICALSVEKYNEAL--------------------------D-----------------KGIAKECARMLLP-LSTQTKLYMKGSVRS-WIH-YLEV-RLD--------PGTQKEHREIAEAVRTIF---MEQFPVT-ASALGWNTQEER-------------------------------------------------------------------------------------------------------------- Prosthecochloris_vibrioformis_ZP_00660891 ----------------------------------------------------------------------------------------MQVRLIALTAPQIDIEGQSL---------------------------TAEGLMAYCARVSS-------------PHQ-----------------------------ESTDYEKLLAYCI--AHKHWSIFE------------MADM----------------------------------------------------------------------------------------------------------------TVEIV------------------------------------------------------------------------------------------------------------------------------TSRAISPQI-LRHKS-FQFQEFSQRYAQA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSIE-------------------------RYTPRRQDSKNRQNSL-DD---LPPETVAW-------------FDEAQERVATESMALYEAAL--------------------------E-----------------KGIAKECARALLP-LATQTKLYMKGSIRS-WIH-YLEV-RTD--------PSTQKEHREIADGIMAIF---VKQFPVT-ASALGWS------------------------------------------------------------------------------------------------------------------- Pyrobaculum_aerophilum_AAL63766 ----------------------------------------------------------------------------------MVILETPRVFLIASW--------------------------------------GSEAVISAFTDALY----------------------------RGVPWEEAVKAQ-----APDVIIKRISAFY--RQGHWSVFE------------FMGA----------------------------------------------------------------------------------------------------------------QFLVE------------------------------------------------------------------------------------------------------------------------------CSRACHTQF-IRHRM-ASYWSESQRYVDYTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------REIR------------FVVPKGF-----------------------------------------------------PADLLKRAYEDYARLR--------------------------------------------EGFRPEYARMILP-NATAVLFAVQMNARELLLN-FAPL-RCA--------YAAQAEIRHVCWQMFAHA---WRLWPNL-ARLVWEDLPSLHRDFC--TKVPRGEDCRLYAIKDAEEKHGPLPETPWLSALVHG-------------------------------------------------------------------- Pyrococcus_abyssi_CAB50208 ---------------------------------------------------------------------------------------MVRVTLVNYTR-------------------------------------RPLETITWAALVSY-------------WDEWST---------------ESFEKI-----NEDDVKAHLPRIL--GYGHESILE------------HATF----------------------------------------------------------------------------------------------------------------TFSIEG-----------------------------------------------------------------------------------------------------------------------------CSRVCTHQL-VRHRI-ASYTQQSQRYIVLNEEN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEET------------FVIPESI----------KKDRE----------------------------------LYEKWKKAMAETIKLYKESLK-------------------------------------------RGIHQEDARFILP-QAVRSKIVVTMNLRE-LKH-FFGL-RLC--------ERAQWEIREVAWKMLEEIAKREELRPIIKWAKLGPRCIQLGYCPE--RELMPPGCFKRTRERWMKLLEKPL-------------------------------------------------------------------------------- Pyrococcus_furiosus_AAL80664 ---------------------------------------------------------------------------------------MVRVTLVNYTK-------------------------------------RPLETITWAALISY-------------WGEWST---------------ESFERI-----SENDVEKHLPRIL--GYGHESILE------------HATF----------------------------------------------------------------------------------------------------------------TFSIEG-----------------------------------------------------------------------------------------------------------------------------CSRVCTHQL-VRHRI-ASYTQQSQRYIVLDEEN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEET------------FVIPESI----------KKDRE----------------------------------LYEKWKKVMAETISLYKESIN-------------------------------------------RGVHQEDARFILP-QAVKTKIIVTMNLRE-LKH-FFGL-RLC--------ERAQWEIREVAWKMLEEMAKRDDIRPIIKWAKLGPRCIQFGYCPE--RDLMPPGCLKKTRKKWEKVAESKS-------------------------------------------------------------------------------- Pyrococcus_horikoshii_NP_142699 ---------------------------------------------------------------------------------------MVKVKLINYTP-------------------------------------KPLETVTWAALISY-------------WDGWST---------------EAFEKI-----SPNDVEIHLPRIL--SYGHESILE------------HATF----------------------------------------------------------------------------------------------------------------TFSIEG-----------------------------------------------------------------------------------------------------------------------------CSRVCTHQL-VRHRI-ASYTQQSQRYIKINPED-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEET------------FVIPESI----------KKDSE----------------------------------LLKEWKELLKRSLELYEKSIE-------------------------------------------RGIHQEDARFILP-QSVKTKIVVTMNLRE-LKH-FFGL-RLC--------ERAQWEIREVAWKMLEEIAKRKELKPIIEWAKLGPRCIQLGYCPE--RELMPPGCLKRTRERWKNLLEKY--------------------------------------------------------------------------------- Rhodococcus_sp_ABG98518 ----------------------------------------------------------M------------------------PQTVPLRVQLVAKTEFFPPADIPW--ETDAD---------------------GGEALAEFAGRACY-------------QSWSKP-------------------NP-----RTATNAGYLRHLL--EVGHESVLE------------HGTV----------------------------------------------------------------------------------------------------------------SFYITG-----------------------------------------------------------------------------------------------------------------------------ISRSCTHEL-IRHRH-FSYSQLSQRFVRE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDGN------------VVVPPAI----------AGDPE----------------------------------LEELFAKATDASRAAYGELLEALETKL-ADTS----------SVPLR-----------------NKQARQAARAVLP-NATETRVVVTGNYRA-WRH-FVSM-RAT--------EHADVEIRRVAVECLRQL---QAAAPNV-FGDFEVLVWGDGTEVA--RSTFSADA------------------------------------------------------------------------------------------------ Rhodospirillum_rubrum_YP_427876 ---------------------------------------------------------------------------------MTELLFAPTATVVAHSSMDPAGLAGWAAEMGYGALIDDATTPLGDIAQASTGAGSADVLPEFAGRFCY-------------RSFKKG----------------------------RPADEYVAHIL--DSGHGSVLE------------HVSV----------------------------------------------------------------------------------------------------------------SFAVTG-----------------------------------------------------------------------------------------------------------------------------VSRALTHEL-IRHRAGTAVSQESQRYVDA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSVN------------FVVPPLLVAEIDRLKASGAAGEADA-------------------------------LCAEFLTDCESALGRYKRWQESFRAQVEALGVS---------EPTLI-----------------KKRANEAARCILP-NATETRLVWTMNLRS-ARH-VVEL-RGH--------RDADLEIRRLSCLLARKM---KEVAPLV-FADVGVFTDSDGFESV--GVGHHKV------------------------------------------------------------------------------------------------- Rickettsia_akari_ZP_00340125 ------------------------------------------------------MHNTTKRVTVPALEEI-----LYE--PIKVLDH-GFIRVIDYM--------------------------------------GDDSAIVQAARVSY-------------GKGTKQ---------------------------LNQDKGLINYLL--RHYHTTPFE------------MCDI----------------------------------------------------------------------------------------------------------------KFHIK------------------------------------------------------------------------------------------------------------------------------LPIFIARQW-VRHRT-ASVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-NE------------FYLPEPA--------NIASQSVVNKQCRE-CD--SLPKEVAEK-------------VLAILEEDARQCYVHYKELM--------------------------NADEDGNMIDEN-----TTGIARELARMNLT-LNYYTEWYWKINLHN-LLH-FLRL-RAD--------THAQYEIRVYAEKMLEIV---KAWVPFT-YEAFEEYRLRGANISR--KGLCVIKRMINGEQVTH-KSS-GMTKREWEELMKIFC------------------------------------------------------------------- Rickettsia_bellii_ZP_01380446 ------------------------------------------------------MNNATKRVVVPALEEI-----LYE--PIKVLDH-GFIRVIDYM--------------------------------------GDDSAIVQAARVSY-------------GKGTKQ---------------------------LNQDKGLINYLL--RHYHTTPFE------------MCDI----------------------------------------------------------------------------------------------------------------KFHIK------------------------------------------------------------------------------------------------------------------------------LPIFIARQW-IRHRT-ASVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-NE------------FYLPEPQ--------NIAPQSSTNKQCRE-SD--SLPKEVAEK-------------VLNILEEDARNCYKHYTELM--------------------------NTDEEGNIIDDN-----NTGIARELARMNLT-LNYYTEWYWKINLHN-LLH-FLRL-RAD--------PHAQYEIRVYAEKMLDIV---KAWVPFT-YEAFEEYRMCGANISR--KGLEVIKKMISGEKVTH-ETS-GMTKREWEELTKILK------------------------------------------------------------------- Rickettsia_canadensis_ZP_01347808 ------------------------------------------------------MHNTTKRLVVPALEEI-----LYE--PIKVLDH-GFIRVIDYM--------------------------------------GDDSAIVQAARVSY-------------GKGTKQ---------------------------LNQDKGLIHYLL--RHYHTTPFE------------MCDI----------------------------------------------------------------------------------------------------------------KFHIK------------------------------------------------------------------------------------------------------------------------------LPIFIARQW-IRHRT-ASVNEYSARYSIV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-NE------------FYLPEPA--------NIASQSAVNKQCRE-GD--SVPKAIAEK-------------VLMILEKDARQCYGHYTELM--------------------------NTDAEGNIIDEN-----AIGIARELARMNLT-LNYYTEWYWKINLHN-LLH-FLRL-RAD--------SHAQYEIRVYAEKMLEIV---KVWVPFT-YEAFEEYRLHGATISR--KGLDVIKRMIKGEKVTH-ETS-GMTKREWEELRTIFLGS----------------------------------------------------------------- Rickettsia_conorii_AAL02943 ------------------------------------------------------MHNTTKRVTVPALEEI-----LYE--PIKVLDY-GFIRVIDYM--------------------------------------GDDSAIVQAARVSY-------------GKGTKQ---------------------------LNQDKGLINYLL--RHYHTTPFE------------MCDI----------------------------------------------------------------------------------------------------------------KFHIK------------------------------------------------------------------------------------------------------------------------------LPIFIARQW-IRHRT-ASVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-NE------------FYLPEPA--------NIASQSAVNKQCRE-GD--SLPKEVAEK-------------VLAILEEDARQCYGHYKELM--------------------------NADEEGNIIDEN-----ATGIARELARMNLT-LNYYTEWYWKINLHN-LLH-FLRL-RAD--------PHAQYEIRVYAEKMLEIV---KAWVPFV-YEAFEEYRLQGANISR--KGLDVIKRMINGEKVTH-ETS-DMTKREWEELMKIFG------------------------------------------------------------------- Rickettsia_felis_AAY61342 ------------------------------------------------------MHNTTKRVTVPALEEI-----LYE--PIKVLDH-GFIRVIDYM--------------------------------------GDDSAIVQAARVSY-------------GKGTKQ---------------------------LNQDKGLINYLL--RHYHTTPFE------------MCDI----------------------------------------------------------------------------------------------------------------KFHIK------------------------------------------------------------------------------------------------------------------------------LPIFIARQW-IRHRT-ASVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-NE------------FYLPEPA--------NIASQSAVNKQCRE-GD--SLPKEGAEK-------------VLAILEEDAKQCYGHYKELM--------------------------NADEDGNIIDEN-----NTGIARELARMNLT-LNYYTEWYWKINLHN-LLH-FLRL-RAD--------PHAQYEIRVYAEKMLEIV---KAWVPFT-YEAFEEYRLQGANISR--KGLDVIKRMIKGEKVTH-ESS-GMTKREWEELMKIFG------------------------------------------------------------------- Rickettsia_prowazekii_CAA14762 ------------------------------------------------------MHNTTKRVTVPALEAM-----LYE--TIKVLDH-GFIRVIDYM--------------------------------------GDDSSIVQAARVSY-------------GKGTKQ---------------------------LNQDKGLINYLL--RHYHTTPFE------------MCDI----------------------------------------------------------------------------------------------------------------KFHIK------------------------------------------------------------------------------------------------------------------------------LPIFIARQW-IRHRT-ASVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-NE------------FYLPDPA--------NIASQSVVNKQCRA-GD--SVPKKVSEK-------------VLAILEEDARRCYRHYKELM--------------------------NADEDGNILDEN-----VSGIARELARINLT-LNYYTEWYWKINLHN-LLH-FLRL-RTD--------PKAQYEIRVYAEKILDIV---KAWVPFT-YEAFEEYRLQGANISR--KGLEVIKRMIKGEKVIH-ETS-GMNKREWEELVKIFR------------------------------------------------------------------- Rickettsia_typhi_AAU03772 ------------------------------------------------------MHNTTKRVTVPALEAM-----LYE--TIKVLDH-GFIRVIDYM--------------------------------------GDDSSIVQAARVSY-------------GKGTKQ---------------------------LNQDKGLINYLL--RHYHTTPFE------------MCDI----------------------------------------------------------------------------------------------------------------KFHIK------------------------------------------------------------------------------------------------------------------------------LPIFIARQW-IRHRT-ASVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-NE------------FYLPEPT--------DIASQSAINKQCRA-GD--SLPKKVSEK-------------VLAILEEDARRCYMHYKELM--------------------------NADEDGNIIDEN-----VAGIARELARMNLT-LNYYTEWYWKINLHN-LLH-FLRL-RTD--------SKAQYEIRVYAGKILDIV---KAWVPFT-YEAFEEYRLQGANISR--KGLEVIKRMIQGEKVIH-ETS-GMNKREWEELVKIFR------------------------------------------------------------------- Roseiflexus_sp_ZP_01355916 -----------------------------------------------------------MEPTISDPWGDRFSEAERALLAPFVTDVDAPVFGLRNLPDV-----------------------------------VRGALFSRYSRSDK-SLRRILLDEFIQAPEADF-----HAIVALSADAAAHQIV-----AVHRAEAFYERVL-IGYGDDSVAE------------LGGA----------------------------------------------------------------------------------------------------------------HVACEG-----------------------------------------------------------------------------------------------------------------------------VSNIAAKAL-EDSRIGISPLEKSTRYVAFNRKVEGRYRYLR-EAAIMASRHARAYETAMDFLFDTYSALIEPTLAAVRAHTPREP--------------------GVSERAYASATRARTFDLLRGLLPMATLTNVGLFGNGRAFEYLLTKLYASPLAELQALATALQRALDDQIPSFVKRAKS-------------------------ERGRAYQAYLRETRQEVQTLAAAVAHRLAEVASAS---PDVTLVAFDLDADVRVVAAILYPHLDSSLADARALAEAMTADERMRLIRAYAGRRASRFHRPGRAFEEARYTFDLLADIGAYRDLQRHRMLTQERQRFGVQHG----YVVPPEIDEYG---------------------------------------------LGAPFRAALDQAGEVVSAI---------------------------------------------AADLPEEAQYAVP-FAYRVRWRVTLNLRE-AYH-LCEL-RSA--------PQGHPGYRRIAQEMYRQI---AAVHPLL-AEGMRFVDMNDYALER--LDAERRLDEKRRKLSKEQQVNE---------------------------------------------------------------------------------- Roseovarius_nubinhibens_ZP_00960246 --------------------------------------MPLSPEQQSEIDAQRAETRPTRRVVSEGMEGH-----LYT--AYPVLDH-GFVRVVDYM--------------------------------------GDDAAITQAARVSY-------------GKGTKS---------------------------VQNDEGLIRYLM--RHWHSTPFE------------MCEV----------------------------------------------------------------------------------------------------------------KLHVK------------------------------------------------------------------------------------------------------------------------------LPVFVARQW-IRHRT-ANVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-RE------------FYIPAPE--------HLAAQSVVNNQGR--GE--ALEGEEAER-------------VLRYLRDDAMRAYDHYEEMI--------------------------GQ--------DG-----QQGLARELARMNLP-ANIYTQWYWKVDLHN-LLH-FLRL-RAD--------AHAQYEIRVYAEELCKIV---ADWVPFA-YKAFEDYRMGGATLSS--GALDCVRRMIKGEEVTQ-ENS-GMSKGEWREFEAALKG------------------------------------------------------------------ Roseovarius_sp_ZP_01038219 --------------------------------------MPLSPDQQAEIDAQRGQTQTTLRATAPGMEQH-----LYT--AHPVLDH-GFVRVIDYM--------------------------------------GDDAAIVQAARVSY-------------GAGTKH---------------------------VQNDEGLIRYLM--RHWHSTPFE------------MCEI----------------------------------------------------------------------------------------------------------------KLHVK------------------------------------------------------------------------------------------------------------------------------LPVFVARQW-IRHRT-ANVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-RE------------FYIPAPD--------ALNAQSTTNNQGR--GA--ALEGEEAQR-------------VLRLLTEDAMRCYDHYEDMI--------------------------SQ--------DG-----QQGLARELARMNLP-ANIYTQWYWKVDLHN-LLH-FLRL-RAD--------AHAQYEIRVYADEICRLV---ADWVPYA-YKAFEDYRMGGATLSA--TALDCVRRMLKGETVTQ-ETS-GMSKGEWREFEGVLNAPA---------------------------------------------------------------- Rubrobacter_xylanophilus_YP_645362 --------------------------------------------------------------------------------------------MISRPQVGLGGLSGFLEGFDPGLRFPEYLEDPVRLP-------GSSQLCKTAGQTCY-------------MSFGPR-------------------RT-----RNADAAGYFERLI--SAGHGSVLE------------HASF----------------------------------------------------------------------------------------------------------------GFLLYG-----------------------------------------------------------------------------------------------------------------------------VSRSVTHEL-VRHRAGTAFSQVSQRYVSG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVLR------------FVERPEY----------QDDGE----------------------------------LHRLFEERIDRAAAEYGELADRLLRLQEA-----GDERLAADRATDA-----------------RKKVQQAARSLLP-NETEAPLVFTANVRA-LRH-IIEM-RAD--------AHAESEIRGLALRLFLCL---RRADPIL-FGDYRVLRLPDGTFTV--TTEHRKA------------------------------------------------------------------------------------------------- Salinispora_tropica_ZP_01428560 -------------------------------------------------------------------------------------MVQPQVKLIAWTQFAVPDDVEW--STDAD---------------------GGQALAEFAGRACY-------------QSWKKP-------------------NP-----ATATNAGYLAHIL--EVGHLSVLE------------HGSV----------------------------------------------------------------------------------------------------------------SFYFTG-----------------------------------------------------------------------------------------------------------------------------VSRSLTHEL-IRHRH-FSYSQLSQRYVPE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDAA------------MVEPAVI----------ADDPE----------------------------------LHKRFVEAAEASVRAYTELLEGLEQRF-TDEP----------NATLR-----------------RKRARQAARAVLP-NATETRIVVTGNYRA-WRH-FIAM-RAT--------EHADVEIRELAVECLRQL---QGVAPNV-FNDFVISSLPDGSEVA--ASPHAEVS------------------------------------------------------------------------------------------------ Silicibacter_pomeroyi_AAV94565 ---------------MAVLMRLLAIYSIVATHLAKGTLMPLSSEQLAEIDAQRAHTAPTRRVVSPGMESH-----LYR--AHPVLDH-GFVRVIDYM--------------------------------------GDDAAICQAARVSY-------------GTGTKS---------------------------VQNDEGLIRYLM--RHWHSTPFE------------MCEL----------------------------------------------------------------------------------------------------------------KLHVK------------------------------------------------------------------------------------------------------------------------------LPVFVARQW-IRHRT-ANVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-RE------------FYIPAPE--------HVAAQSAVNNQGR--GE--ALQGEEAAR-------------VLEILKADSARCYDNYEAMI--------------------------GQ--------EG-----QQGLARELARMNLP-ANIYTQWYWKVDLHN-LFH-FLRL-RAD--------AHAQYEIRVYAETMCRLV---ADWVPFA-YKAFEDYRLGAVNLSA--QMVDSLRRMLAGEAVTQ-ETS-GLSAREWREFQDVIGR------------------------------------------------------------------ Streptomyces_avermitilis_NP_823693 ------------------------------------------------------------------------MTDTPADDLKPSFRSDVTVELVKHS--------------------------------------AADSDVLWAARVST-------------AGEQSL---------------------DELKKDPERSKGLINYLM--RDRHGSPFE------------HNSM----------------------------------------------------------------------------------------------------------------TFFIS------------------------------------------------------------------------------------------------------------------------------APIFVFREF-MRHRVGWSYNEESGRYREL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EPV-------------FYVPGES----------RKLVQEGRPGK--YVFVEGTQAQQEL-------------TGRVMEDSYRQAYEAYQEML--------------------------A-----------------AGVAREVARAVLP-VGLFSSMYATCNARS-LMH-FLGL-RTQHELAKVP-SFPQREIEMVGEKMEAEW---AKLMPLT-YAAFNTNGRVAP-------------------------------------------------------------------------------------------------------------- Streptomyces_coelicolor_CAA20294 ------------------------------------------------------------------------MTDIPADDPKIELRSDITVELVKSA--------------------------------------ATDSDVLFAARVST-------------AGEQSL---------------------DELKKDPERSKGLINYLM--RDRHGSPFE------------HNSM----------------------------------------------------------------------------------------------------------------TFFVS------------------------------------------------------------------------------------------------------------------------------APIFVFREF-MRHRVGWSYNEESGRYREL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPV-------------FYAPDAS----------RKLVQQGRPGK--YVFVEGTPEQHEL-------------VGSAMEDSYRQAYATYQQML--------------------------A-----------------AGVAREVARAVLP-VGLYSSMYATCNARS-LMH-FLGL-RTQHELAKVP-SFPQREIEMAGEKMEAEW---ARLMPLT-HAAFNANGRVAP-------------------------------------------------------------------------------------------------------------- Streptomyces_phage_CAA07140 ----------------------------------------------------------------------------------------MKVNVLATTALNPSPLLDAYEYRVSGAAYNRDRPT------------DADALGEAAGRICY-------------KSFERK-------------------NP-----ATASNPGYLGNIL--AQGHFSVLE------------HASV----------------------------------------------------------------------------------------------------------------TFLVRD-----------------------------------------------------------------------------------------------------------------------------VSRALLTEL-SRHRH-LSFSVVSQRYVDH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADTE------------PVVPPAI----------RGTE-----------------------------------LEKPFREDYAEALQAYDAGVKLLR------------------ARGYG-----------------RKQAREAARALLP-NAAPVDMVVTGNLRA-WRD-VLGK-RWH--------VAADAEIREFAGRVLDHL---HAVAPNS-VQDMPTSPFGSDGK------------------------------------------------------------------------------------------------------------ Sulfitobacter_sp_ZP_00955358 --------------------------------------MPISPDQQAEIDALRAEPKQTLRTVSEGMEAH-----LYK--AIPVLDH-GFVRVIDYM--------------------------------------GDDAAICQAARVSY-------------GRGTKS---------------------------VQNDEGLIRYLM--RHWHSTPFE------------MCEI----------------------------------------------------------------------------------------------------------------KLHVK------------------------------------------------------------------------------------------------------------------------------LPVFVARQW-IRHRT-ANVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-RE------------FYIPEPS--------HVNAQSVVNNQGR--GG--VLEGAEAAR-------------VLEILKSDSNRAYDNYEAMI--------------------------AE--------TGPDGEPQDGLARELARMNLP-SNIYTQWYWKVDLHN-LFH-FLRL-RAD--------AHAQYEIRVYADAICNVV---ADWVPAA-YRAFEDYRLGGATMSN--TALECIRRMVKGEEVTQ-ETS-GMSKGEWREFKGVIDG------------------------------------------------------------------ Sulfolobus_acidocaldarius_AAY81629 ----------------------------------------------------------------------------------------MKIKLVSYSK-------------------------------------DGERIVAIAAKMSR-------------SRKGWD---------------YHEKEM-----TDDEIETWIRDSI--THGYWSVLE------------HSVY----------------------------------------------------------------------------------------------------------------TFSIEG-----------------------------------------------------------------------------------------------------------------------------ISRVASHQL-VRHRI-ASYTQMSHRFAKPVD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYYK------------PITPPSI----------EKRG------------------------------------KEVVDKAYQDAYNYFYQLLE-------------------------------------------KGVPEEDARYVLP-NGVNTNIVVTMNARE-LYN-FFGL-RLC--------SRAQWEIRAIAWKMLDEV---KRVHPRL-FKYAGPNCIIHENFIR--ENPITLDDI----DNTVFISQRCIEGVTREGIPKCVKNARSILVSEDGVVMGK--------------------------------------------------- Sulfolobus_solfataricus_AAK40656 ---------------------------------------------------------------------------------------MISVKLVSYTN-------------------------------------DGEKVIAIAAKMSR-------------SRKGWD---------------YHEKDM-----TDDEIETWIRDAI--LHGYWSVLE------------HSVY----------------------------------------------------------------------------------------------------------------TFSIEE-----------------------------------------------------------------------------------------------------------------------------ISRVASHQL-VRHRI-ASYTQMSHRFAKPID-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EYYK------------PIIPPSA----------KKRS------------------------------------KELVEKAYKEAYDNYYTLLE-------------------------------------------SGVPEEDARYVLP-NGVNTNIVVTMNARE-LYN-FFSL-RLC--------SRAQWEIRAIAWKMLEEV---KKVHPRL-FKYTGPNCIIHENFIRNENESITLEDIFKDYKLE-FISQRCIEGVLRDGIKKCIINSRSVLDNIK--------------------------------------------------------- Sulfolobus_tengchongensis_CAH04199 ----------------------------------------------------------------------------------------MIVRLVSYSP-------------------------------------DGEKVVAIAAKMSR-------------SRKGWD---------------YHEKEM-----TDEEIETWIRDAI--LHGYWSVLE------------HSVY----------------------------------------------------------------------------------------------------------------TFSIEG-----------------------------------------------------------------------------------------------------------------------------ISRVASHQL-VRHRI-ASYTQMSHRFARPID-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EYYK------------PIIPISI----------KKRD-----------------------------------VHELVNKAYNNAYEIYYELLK-------------------------------------------SGIPEEDARYVLP-NAVNTNIVVTMNARE-LYN-FFSL-RLC--------SRAQWEIRAIAWRMLEEV---KKVHPRL-FRYAGPNCIIHENFIR--NEYITLDDVLKNHNIE-FISQRCIEGVNRDGIIKCIINSRGVINSI---------------------------------------------------------- Synechococcus_elongatus_YP_171214 -------------------------------------------------------------------------------------MNRFRVEVISCTP-------------------------------------NPQQTIYAAMHQDY-------------SESFVV-------------EERDRWPA-----EAQAGEVIVKRLLAGERGHYGPLE------------HAMI----------------------------------------------------------------------------------------------------------------VFNVGY-----------------------------------------------------------------------------------------------------------------------------FPHSVMQQA-RTHRIGVSFDVQSMRYTGQRVADAAAGKIDL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDIF------------YLRPVGQ-----------------------------------YLDRQGKKYTYTETDRAKDLELCRQAALRYQELLE-------------------------------------------AGYAEEHARGILP-FDYRQHFVVSFTLRS-LMH-FLDL-RSK--------KDAQIEIQQLCDLLWPHF---QTWAPAI-AQWYASTRLGKARLAP---------------------------------------------------------------------------------------------------------- Synechococcus_phage_AAL73301 --------------------------------------------------------------MNTKTTAQQSHQHPHQSTLFNPTFNMSKVSLISVTP-------------------------------------DAEELIAYLARVSN-------------KDAK----------------------------LGDPADRLIRYLI--KHGHWSPFE------------MAHM----------------------------------------------------------------------------------------------------------------VVEIE------------------------------------------------------------------------------------------------------------------------------TTRAIAPQI-LRHRS-FSFQEFSQRYAVA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLGE------------FEVP-----------ELRRQDTKNRQNSI-DD---LPAEIVAE-------------FQSEIDEVFETTRVLYQRML--------------------------S-----------------YGVAKECARGILP-LNTPTKLYMSGTIRS-WIH-YCQL-RCG--------NGTQEEHRLIAEECKNLL---YANLPNV-AKAAFMS------------------------------------------------------------------------------------------------------------------- Synechococcus_sp_ABB34049 -----------------------------------------------------------MITTTRHSDA---------------PMDRFRVDLIAATP-------------------------------------NPQQCVYAAMHQDY-------------SEGFVA-------------ADRANWPD-----EQRAGEICVKRLLSGERGHYGPME------------HAQI----------------------------------------------------------------------------------------------------------------VLNVGC-----------------------------------------------------------------------------------------------------------------------------FPHSVMQQA-RTHRVGVSFDVQSMRYTGERICRAADGALDL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDVF------------YLRPVGE-----------------------------------YSDRQGKKYTYTEALRQQDLDLCRSAAERYRDLLK-------------------------------------------AGFAEEHARGILP-FDYRQHFVVSFSLRA-FLH-FMDL-RAK--------LDAQLEIRQLCDLMWPHM---VNWAPEF-AAWYEKTRLHRARLAP---------------------------------------------------------------------------------------------------------- Synechococcus_sp_CC9311_YP_729554 -----------------------------------------------------------M-------------------------DSRFRVDLIAATP-------------------------------------NPQQCVYVGMHQDY-------------SEGFVA-------------ADREQWPD-----ETRAGEICVKRLLAGERGHYGPME------------HAQI----------------------------------------------------------------------------------------------------------------VLNVGW-----------------------------------------------------------------------------------------------------------------------------FPHSVMQQA-RTHRVGVSFDVQSMRYTGDRICRAAVGELDL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEVF------------YLRPVGE-----------------------------------YSDRKGKKYLYSEAERQKDLNHCKISADRYQELLQ-------------------------------------------AGYAEEHARGILP-FDYRQHFVVSFTLRA-FLH-FMDL-RAK--------LDAQQEIRELCDLMWPHL---KTWTPEF-AGWYEKTRLHRARLAP---------------------------------------------------------------------------------------------------------- Synechococcus_sp_CC9902_ABB27029 -----------------------------------------------------------M-------------------------DPRFRVDLIAATP-------------------------------------NPQQCVYVGMHQDY-------------SEGFVA-------------ADREQWPD-----ETKAGEVCVKRLLAGERGHYGPME------------HAQI----------------------------------------------------------------------------------------------------------------VLNVGW-----------------------------------------------------------------------------------------------------------------------------FPHSVMQQA-RTHRVGVSFDVQSMRYTGERICRAAAGELDL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEVF------------YLRPVGQ-----------------------------------YSNRQGKKYAYSQAERDKDLHHCKISADRYQELLE-------------------------------------------AGFAEEHARGILP-FDYRQHFVVSFTLRA-FLH-FMDL-RAK--------LDAQQEIRELCDLMWPHL---QAWTPEF-AAWYEKTRLHKARLAP---------------------------------------------------------------------------------------------------------- Synechococcus_sp_JA23Ba_213_YP_478001 ------------------------------------------------------------------------------------MDALFQVVVLNQTP-------------------------------------DPERVIYQAMHQDY-------------SPDFVT----------------SESRI-----PEKYGEAVVRHLLEGNRGHYGPLE------------HPQI----------------------------------------------------------------------------------------------------------------TFGVGY-----------------------------------------------------------------------------------------------------------------------------FPHAVMQQA-RTHRVGISFDVQSFRYTGQQIADLGKKLLFASAVRSTTETAAPVGETGYGCVSDRVSGPEAYRDSGAEHIAEHSG-----------GTESSLSLQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELETLF-------------YVPASV----------KEGK---------------------AKTRQGCKPISPAALDIILAQYRSQAIAYYRLVEE-------------------------------------------CGLPYEDARNIIG-YGIRQHFVVSFNCRS-LMH-FLDL-RAK--------EDAQREIQHLCELIWPHF---EAWCPHV-AAWYRKHRWGKARLSP---------------------------------------------------------------------------------------------------------- Synechococcus_sp_JA33Ab_YP_473724 ------------------------------------------------------------------------------------MDALFQVVVLSQTP-------------------------------------DPERVIYQAMHQDH-------------SPDFVT----------------PESRI-----PEKYGEAVVRHLLEGNRGHYGPLE------------HPQI----------------------------------------------------------------------------------------------------------------TFGVGY-----------------------------------------------------------------------------------------------------------------------------FPHAVMQQA-RTHRVGISFDVQSFRYTGQQIADLGKRLL--SGPRRTPPNPPP---------GPPNQPPSPPYTGGWDETSAFAD-----------KTGAELALQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELETLF-------------YVPASV----------KEGK---------------------AKTRQGFKPISPEALNIILEQYRSQAIAYYRLVEE-------------------------------------------CGVPYEDARNIIG-YGIRQHFVVSFNCRS-LMH-FLDL-RAK--------EDAQREIRELCELMWPHF---EAWCPHV-AAWYRQNRWGKARLSP---------------------------------------------------------------------------------------------------------- Synechococcus_sp_RS9917_ZP_01080929 -----------------------------------------------------------M-------------------------DSRFRVDLIAATP-------------------------------------NPQQCVYAGMHQDY-------------SEGFVA-------------ADRDNWPD-----ETRAGEICVKRLLAGERGHYGPLE------------HAQI----------------------------------------------------------------------------------------------------------------VLNVGW-----------------------------------------------------------------------------------------------------------------------------FPHSVMQQA-RTHRVGVSFDVQSMRYTGERICRAANGDIDL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEVF------------YLRPEGQ-----------------------------------YSDRQGKKYAYTAAERSKDLALCRAAAARYRDLLA-------------------------------------------AGFAEEHARGILP-FDYRQHFVVSFSLRA-FLH-FMDL-RAK--------LDAQQEIRELCDLLWPHL---QQWAPEF-ATWYEKSRLHKAKLAP---------------------------------------------------------------------------------------------------------- Synechococcus_sp_WH_5701_ZP_01084768 -------------------------------------------------------------------------------------MDRFRVELIAATP-------------------------------------NPQQCVYAAMHQDY-------------SEGFVA-------------ADRTEWPD-----ERTAGEICVKRLLSGERGHYGPLE------------HAQI----------------------------------------------------------------------------------------------------------------VLNVGW-----------------------------------------------------------------------------------------------------------------------------FPHSVMQQA-RTHRVGVSFDVQSMRYTGDRICKAADRSLDL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEVF------------YLRPIGD-----------------------------------YSDRQGKKYSYDGVQRALDLELCRKAAERYRDLLA-------------------------------------------AGFAEEHARGILP-FDYRQHFVVSFSLRA-FLH-FLDL-RAK--------LDAQLEIRQLCDLMWPHL---ESWAPEI-AAWYSRARLHKARLAP---------------------------------------------------------------------------------------------------------- Synechococcus_sp_WH_7805_ZP_01123511 -----------------------------------------------------------M-------------------------DSRFRVDLIAATP-------------------------------------NPQQCVYAGMHQDY-------------SEGFVA-------------ADRDDWPD-----ETRAGEICVKRLLSGERGHYGPLE------------HAQI----------------------------------------------------------------------------------------------------------------VLNVGW-----------------------------------------------------------------------------------------------------------------------------FPHSVMQQA-RTHRVGVSFDVQSMRYTGERIARAADGELDL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDVF------------YLRPVGD-----------------------------------YSDRQGKKYTYSQALRSQDLQLCKQASERYRDLLR-------------------------------------------AGFAEEHARGILP-FDYRQHFVVSFSLRA-FLH-FMDL-RAK--------LDAQKEIRELCDLMWPHL---QDWAPEF-AAWYEKSRLHKARLAP---------------------------------------------------------------------------------------------------------- Synechococcus_sp_WH_8102_NP_896374 -------------------------------------------------------------------------------------MDRFRVDLIAATP-------------------------------------NPQLCVYAAMHQDY-------------SEGFVA-------------ADRENWPD-----EQRAGEICVKRLLAGERGHYGPME------------HAQI----------------------------------------------------------------------------------------------------------------VLNVGW-----------------------------------------------------------------------------------------------------------------------------FPHSVMQQA-RTHRVGVSFDVQSMRYTGERICRAANGELDL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEVF------------YLRPVGD-----------------------------------YSDRQGKKYAYTESQRALDLDHCRASAERYRDLLS-------------------------------------------AGFAEEHARGILP-FDYRQHFVVSFSLRA-FLH-FMDL-RAK--------LDAQLEIRQLCDLMWPHM---VSWAPEF-AGWYEKSRLHRARLAP---------------------------------------------------------------------------------------------------------- Synechocystis_sp_NP_440394 ----------------------------------------------------------------------------------------MDVRFISLTKPEIVIDGEPL---------------------------SPEGLIAYCARVSS-------------PNQ-----------------------------ENPNYTKLLQFCI--REGHWSIFE------------MVDM----------------------------------------------------------------------------------------------------------------TLEIT------------------------------------------------------------------------------------------------------------------------------TTRAIAPQI-LRHRS-FSFQEFSLRYSCA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEYE-------------------------CYEARRQDVKNRQNSL-DD---FDESTKKW-------------FNQAQAAVWEKSHQLYEEAL--------------------------A-----------------KGIAKECARSILP-LNTVTRLYMKGSVRS-WIH-YFSV-RCD--------QATQKEHREIALAARKIF---MKHFPTV-AAALEW-------------------------------------------------------------------------------------------------------------------- Syntrophobacter_fumaroxidans_ZP_00666252 ----------------------------------------------------------------------------------------MSVQFVKTRVQPQGIAPAEEG--------------------------RALQLVELCGRTAY-------------KSEDKI--------------------------TPDSARNFVLMLK--SHGHLSVLE------------HSNI----------------------------------------------------------------------------------------------------------------VLEIEATPSSGATQALSSISELYGALLDGLGFRTAYHRIHLSARTSPGALFIAGNLRSWIETLTHLGNGGSPLHALLSAALRDFFPIIFGGEETVSSNLSFKVTLVREDEQLALLRRDAACDLPVFVFKFVCDRGITHEV-VRHRV-LSFTQESTRYVNYKNKGMV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LILPEELYPFYDDATQQLTGRSP---------------------------------LVDMWIDRAEKLFAWYREDL--------------------------------------------DREKPEIARDILP-NLLKSEIFVSGRWSG-WKH-FVQL-RDS--------KHAHPRIRAIAKEVRNHF---DSLGMTVE-------------------------------------------------------------------------------------------------------------------------- Syntrophomonas_wolfei_EAO22970 ------------------------------------------------------------------------------------------MIIIQPQVLVPEAELDI----------------------------GKMEKLERYARVCY-------------KSEDKM-------------------DT-----TTGQAGSFLKGLM--KRGHESIIE------------HEKI----------------------------------------------------------------------------------------------------------------TVLFI------------------------------------------------------------------------------------------------------------------------------IDRGISHEI-VRHRI-AAYSQESTRYCNYSRDRFG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QEIT------------LIEPFFF----------LNDQK----------------------------------AYELWYHSCMLAEKNYMALLA-------------------------------------------AGRSAQEARSILP-NSLKTEIVVSYNIRE-WRH-FFRL-RCD--------MAAHPQMRQVAIPLLLLF---RERFPFL-FEDIAYDQTFPSEYYG--QIILTDELFTPRQS------------------------------------------------------------------------------------------ Syntrophus_aciditrophicus_YP_462966 -----------------------------------------------------------MDVGNMHLIKTLSMDIVRVVFSQTRSPLMMKILLAGYNLDYETIRELQAARPELRNL-------------------TPETISAAYARISR-------------DPRPVHELRAVARE------------------EVEKARQSNRTIV-FGLGHSSVAE------------HAVF----------------------------------------------------------------------------------------------------------------NIDILG-----------------------------------------------------------------------------------------------------------------------------ISRLLVEEI-QRFRL-CSYTEKSQRYILLTDDFVI-------PEEIRDTGLEEIFRETVREQNSLYHTLYARLLPHVLEKNPEMA----------------------AVPEKRSTLEGWAKEDARYIVSLATEAQLGMTLNARGLELLLRRFAAHPLEECRAFSQHLYEKTFEIAPSLIRYTEP----------------------TPFDRDTPTALRRMTDELIARHAAGPEEEERNSENRKDWQRGDVRLIDASPDADDRILAALLHTSSRAPLDRCRNLLHRMDTVEKIALLKEAFRFLSEHDA-VQREFEYADLTFELTLSASCFAQLKRHRMATLTVQDYNPDLS----VTIPPAIIEVG---------------------------------------------MESAFREVIDRTEAIYRQI---------------------------------------------AQTVPQAAPYILT-NAHRRRAILKVNARE-LYH-MARL-RLD--------AHAQWDIRRLTGNMLTLA---RKVMPLT-LLLATGKDGFAAAYGT--LFSDRQQE------------------------------------------------------------------------------------------------ Thermoanaerobacter_ethanolicus_ZP_00779467 ------------------------------------------------------------------MKMRKLTLEEERLLENFVTDVYGPVYFIHSLPEFIIPPINSKVSRRDTSWRLNILESLTD---------GDLNITDYIPKHNI-----------------------------------------PLEKAIQKAKEFHEKWV-ERFGHSSIAE------------QHLM----------------------------------------------------------------------------------------------------------------HLCVED-----------------------------------------------------------------------------------------------------------------------------VSRLLSGDIELMNRR-PAFIEWSQRYQKPTRDKVVI-----PQELEEKPDLKEKFLKVWNNSYDAYEKLVEVLTEYLARAEEKKE--------------------GESEERFYNRISKIAFEDARYALLLATKTSFAVALNALDLQDIVRKLFVHPTKEAKLLAERIVEQGEKIAPSMLRHTAP-------------------------------TVYQLKVHDRLKNLASVVKEDELSDSNEDVILIDYTGKDSEYSPVDIVIMHILFTYSGKNFEAVRKTVKNMSEEEKSKILQQAVEDIGEFDH-LIEAFKSIRFKFQLKISEANWHQLLRHRTIVFDYSEPTIENG----FVIPPNIEKAN---------------------------------------------ASEILIEAIKASEELFIEL---------------------------------------------KEKLPEVSPYVVT-NAHKRLVLMNADLWA-FDH-FANL-RCT--------NEAQWDIRNVSFKMLDLI---KEVAPQL-TTFMARRKKA---------------------------------------------------------------------------------------------------------------- Thermoanaerobacter_tengcongensis_AAM25376 ------------------------------------------------------------------MQMRKLTPEEEKLLQNFVTDVYGPVYFIHSLPEFIIPPINSKVSRKDTSWRLNILESLTD---------GDLDITEYLPKHSI-----------------------------------------PMERAIEKAREFHEKWV-EKFGHSSIAE------------QHLM----------------------------------------------------------------------------------------------------------------HLCVED-----------------------------------------------------------------------------------------------------------------------------VSRLLSGDIELMNRR-PAFIEWSQRYQKPTREKVVI-----PPELEKEPVLKEKFLKVWNATYDAYEKLVKVLTEYLRRAEEKKE--------------------GETEEKFLNRIEKIAFEDARYALILATRTSFAVALNALDLQDIVRKLFAHPTEEAKVLAKRIVEQGEKIAPSTLRHLTP-------------------------------TPYQMKVRERLKDISKKILGDKRAISSDDVVLLDYTGKGTDFSPVDTVVAHILFTYSGKEFVEVKEKVKAMKEEEKEKVIKTAVEEIGEFDH-LIDAFKSVRFKFQLKISEANWHQLLRHRTIIFDWTEPTVENG----FVIPPNVVKAG---------------------------------------------AEDILIGALKTSEELFYEL---------------------------------------------KEKMPEVSPYVVT-NAHKRLVVMNADLWA-FDH-FANL-RCT--------KEAQWDIRETSFKMLGLI---REVAPQL-AFFMARRKRA---------------------------------------------------------------------------------------------------------------- Thermobifida_fusca_AAZ55425 -------------------------------------------------------------------------------MQPVVKHVEPEVHLIARPQLDYDEIARYLADVGGSSWLERLDRGELDEVLN-----DPQNLAEFAGRLCY-------------RSWEPGLNPNVTR-------------------VRTDQTAYLTNIL--ASMHGSVLE------------HVSF----------------------------------------------------------------------------------------------------------------SFVLHN-----------------------------------------------------------------------------------------------------------------------------VSRVATHEL-VRHRPGVAISQESLRFVRL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDLP------------FWFPEWA----------QEDPE----------------------------------LMKRATDLLERMEEFQRWMADHFGLDEEGVPFAV------------------------------KKHRTSFMRRFAP-EGVATGLVWTANVRT-LRH-TLET-RTA--------PGAEEEIRLIFHKIGEIM---VQEAPAL-FGDYTVTDGAWVPKWR--KV------------------------------------------------------------------------------------------------------ Thermococcus_kodakarensis_YP_183283 ------------------------------------------------------------------------------------MDNGIRVKLVNYTK-------------------------------------KPLETVTWAALISY-------------WDEWET---------------ETFGRM-----SDKDVEMHLPRVL--GYGHESILE------------HATL----------------------------------------------------------------------------------------------------------------TFAIEG-----------------------------------------------------------------------------------------------------------------------------CSRVCSHQL-VRHRL-ASYTQQSQRYIVLNPED-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEET------------FVIPSGI----------KEDPE----------------------------------LLAEWKELMKKSIELYKKSVE-------------------------------------------RGQHQEDARFILP-QAVRTKIVVTMNLRE-LKH-FLGL-RAC--------ERAQWEIREVAWKMLEEIAKNDELRPIIKWAKLGPRCVQLGYCPE--GELMPPGCWKRTGEKWKTLFEG---------------------------------------------------------------------------------- Thermoplasma_acidophilum_NP_394882 -----------------------------------------------------------M----------------------SFSNEDRDVFIIKTDRMI-----------------------------------DRGALMSRYSRASDPDIRSVFHREFEGNQK--------------------------------RSEDFYRRIF-LEYGDESIAE------------LVTA----------------------------------------------------------------------------------------------------------------QVGIQN-----------------------------------------------------------------------------------------------------------------------------VSNVISKVI-EEIRIGLSYLEKSTRYVAYDRKVDGHYLFMQAEKIGLSGEAAREYTDLCNRLFDLYSSTLPRIEEEISRQWPIESFDFNIDGNPRNYKELDENGRKLAQKSYRSSVRSRALDDARFILPASTLTNMGVSGNGRSFIHLIQKLMEYGVPESERLAHDLYEELKGEFPQIIDDALS----------------------QHGQDIINYKRSLAS-------------L--FPYTDGGRFEKVRLIKYSNEREEMQKVLALLMYPFAEDASGIISRIKAMELSEASAILERIRDLRKNRRMKVGRPFEAVNYVFEVTTNYGAFRDLQRHRFLSIVRKPLTVSYG----FDVPPIIAKMPD--------------------------------------------LSEEYAEAMKDAERVYRIIK--------------------------------------------ERYGAWIAQYAVP-FAYRYPVVFTTNLAE-ATY-FIEL-RST--------PQAHFDLRDIAIRMYNEI---KSVHPSL-AGIIKFVDTGDYPLGR--LSAEVRKNVKAGGI------------------------------------------------------------------------------------------ Thermoplasma_volcanium_BAB60613 -----------------------------------------------------------M----------------------EFSNAERDVFLIKIEKMI-----------------------------------DRGALMSRYSRASDPDIRSVYEKEFKTGAK--------------------------------SGEEFYRRIF-LEYGDESIAE------------LTTA----------------------------------------------------------------------------------------------------------------QMGIQN-----------------------------------------------------------------------------------------------------------------------------VSNVASKII-EEIRIGLSYLEKSTRYVRYDKKVDGRYLYISPERIGISGDDAKDYVQLCDNLFEFYSKALPQVEDYLRHKFPQDKLVFQNAGG-KTLTEMDQNEKKIAERSYINAVRSRALDDVRYILPASTLTNIGISGNGRALIHLIQKLMEYEIPETTKLAKDIYDELKPELPQLIDDALS----------------------GHGLEIINFKKNLMG-------------L--FPYDLTGNFERIRLLSYGEEDKELRKVASLIEYPFHGDAASLYSRSSESYVKYMKELIESIRSLRANRRMKPGRAFESVNYVFELNLNYGSFRDLQRHRFLGIIRKPLTAAYG----YDTPPVISAIDE--------------------------------------------LKTQYDELMANSSSFYQRLR--------------------------------------------EKYGPWISQYVVP-FAFKYPITFSTNLSE-VTY-FVEL-RST--------AQAHFDLRDIAVSMYREV---SKVHPTL-SRIIKFVDTADYPLGR--LSAEFRKESKKAGI------------------------------------------------------------------------------------------ Thermosynechococcus_elongatus_NP_681946 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQEGRVIADSISPAGVRLV----------------------------------------------------------------------------------------------------------------TLQLT------------------------------------------------------------------------------------------------------------------------------YPRFIHSEL-LTHRV-FSRNSASSRAVPVTKMMAQVEADP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIPYHW-----------GKNQRGMQ-------AREESEQKEA-------------AKEIWLKTRLAVLEGARQLH--------------------------E-----------------LGIHKQVVNRMLE-PWMWMQTVVSSTE---WDN-FLRL-RNH--------PDAQPEMQALAKLIQHLL---ETHEPTP-VAVGDWHLPYIDPIER----QQYSLEECKYMSVARCARVSYYLRDGQRSDPASDLALYERLAGAEPKHLSPLEHVAECMGDRQSYANFVGWRQLRYFEERKSARPRQ--------------- Thermotoga_maritima_1O2B_D ------------------------------------------------------------MGSDKIHHHH-----HHM--KIDILDK-GFVELVDVM--------------------------------------GNDLSAVRAARVSF-------------DMGLKD---------------------------EERDRHLIEYLM--KHGHETPFE------------HIVF----------------------------------------------------------------------------------------------------------------TFHVK------------------------------------------------------------------------------------------------------------------------------APIFVARQW-FRHRI-ASYNELSGRYSKL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-YE------------FYIPSPE--------RLEGYKTTIPPER----------------------------VTEKISEIVDKAYRTYLELI--------------------------E-----------------SGVPREVARIVLP-LNLYTRFFWTVNARS-LMN-FLNL-RAD--------SHAQWEIQQYALAIARIF---KEKCPWT-FEAFLKYAYKGDILKE--VQV----------------------------------------------------------------------------------------------------- Thermus_thermophilus_BAD70919 ---------------------------------------------------------------------------MEGPLTIPVLDK-GFVRLVDQM--------------------------------------GDDRAIVQAARVSY-------------GEGTKT---------------------------VREDAALIDYLM--RHRHTSPFE------------MVVF----------------------------------------------------------------------------------------------------------------KFHVK------------------------------------------------------------------------------------------------------------------------------APIFVARQW-FRHRT-ASVNEISGRYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-EE------------FYEPEAF----------RKQAKRNKQAS--EG--ALLDEE----------------ALALLRKVQQEAYGAYRALL--------------------------E-----------------KGVAREMARMVLP-LNLYTEFYWKQDLHN-LFH-FLKL-RLA--------PEAQWEIRQYARAIAEIV---KERVPLA-WAAFEEHLLEGAFLSR--TELRALRGLLTPEVYEKALSSLGLGGSRLKEALEKVFGPGEAL------------------------------------------------------------- Thiomicrospira_denitrificans_ABB43298 -----------------------------------------------------------------------------MQSIYGIKYTKPEVVLIQE---------------------------------------TGIGVAEAAARTCY-------------DSFENSENRAIQYIEKNMPDSSTCREI-----NGIEESNLLNDLA-WTYFHHSILE------------HANL----------------------------------------------------------------------------------------------------------------SFLVRG-----------------------------------------------------------------------------------------------------------------------------TSRGVLQEH-ARHRM-QAISVRSTRYTMS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVINAFVASMSSNDRDFFIDKVL----SFDMFVTCDKEYNKIEIGAMYDKLFYQSKKVEDFNEIAVATSSLDLLEKFKGTPEALFDALESGKK-------------------------------------------KRNVGDAFKHIIS-DNVKVDMVVTFNLRS-LKN-YFTL-RDS--------GAAYFQIRWLAQEMMRKT-------PSK-YLDLIIKKR----------------------------------------------------------------------------------------------------------------- Treponema_denticola_NP_970925 ---------------------------------------------------------------------------MDK--EFKVLDK-GFIRLVDYM--------------------------------------GTDARIVQSARVSY-------------GEGTKT---------------------------VREDAALIDYLL--RNKHTSPFE------------QVVF----------------------------------------------------------------------------------------------------------------TFHVK------------------------------------------------------------------------------------------------------------------------------LPIFVARQW-IRHRT-ARLNEISGRYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-AE------------FYVPAGK--------DIALQSSDNKQGRM-NE--AVPQDLQNE-------------VITSLQKQQEEIYAGYSKLL--------------------------D-----------------KNIARELARINLP-LSTYTEWYWQIDLHN-LFH-FLRL-RMD--------AHAQKEIRDYAEVMFEIC---KTVTPLA-CASFERHEKNGVNFSA--EELEAIRNLIAGKDSGL-KGK-ELER-----FNEKLKSGRQV-------------------------------------------------------------- Treponema_pallidum_AAC65955 -------------------------------MTLRTLQAGVAVSIALDRVCFFCYNGAVAHCVVEAAEDI-----LDR--RFSVLDK-GFVRLIDYL--------------------------------------GGDARIVQAARVSY-------------GAGTRT---------------------------ARDDAALIDFLL--RNKHTSPFE------------QVVL----------------------------------------------------------------------------------------------------------------TFHVR------------------------------------------------------------------------------------------------------------------------------APIFVARQW-MRHRT-ARISEVSSRYSLL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-HD------------CYVPQET--------SVAVQSTRNKQGRA-SE--GISPEQQQE-------------VRAAFEAQQKAACAAYDALI--------------------------Q-----------------KNIARELARINVP-LSLYTEWYWQIDLHN-LFH-FLRL-RAS--------AHAQAEIRAYAEVIIEIT---RAVAPCA-TASFENHEKDGVQFSG--REFAALKALLAGEGLSL-EGK-ERAR-----FEEKLRSGLQQ-------------------------------------------------------------- Tropheryma_whipplei_NP_787744 ------------------------------------------------------------------------MLQCLFFVMDPVFLSEITVELVKHS--------------------------------------ASDSDVVFSARVST-------------LGSFVA----------------------VTDCLSNRDIGLITFLM--RERHGSPFE------------HSHM----------------------------------------------------------------------------------------------------------------TFRIS------------------------------------------------------------------------------------------------------------------------------APIFVFREF-MRHRI-ASYNEESGRYKNL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPV-------------FYIPDEK----------RKLVQIGAPGA--YKFEEGTSEQYGL-------------LIEEMKELSLAAYDTYKRLL--------------------------A-----------------CGIAREVARMILP-LNLYSTMYVTINARS-LMN-FLSV-RTSRANSAFH-SYPQREIELCADRIEEIW---KGLMPET-HAAFEKQGRVAP-------------------------------------------------------------------------------------------------------------- Wolbachia_endosymbiont_ZP_01314862 ------------------------------------------------------MNEATKRTIVKEIDAI-----LYE--EHKVLDH-GFIRVVDYM--------------------------------------GSDSAIVQAARVSY-------------GKGTKQ---------------------------ISQDEALIKYLM--RHHHTTPFE------------MCEI----------------------------------------------------------------------------------------------------------------KFHVK------------------------------------------------------------------------------------------------------------------------------LPIFVARQW-IRHRT-ANVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-NE------------FYTPKPE--------QVAKQSDNNKQGS--GE--AFDPDTSKE-------------IIDSLINDSNLVYSHYEKFI--------------------------E-----------------QGLAREIARTNLM-LNYYTQFYWKIDLHN-LLH-FLKL-RAD--------KHAQYEIRVYAEVMLDII---KKWVPLA-YNAFVEYCLESACISR--TGLEIIRKLIKGENVTR-EES-NIGKREWGELMSILDKQS---------------------------------------------------------------- Wolbachia_endosymbiont_strain_TRS_Brugia_malayi_AAW71329 ---------------------------------------------------MNEERYSTKRITVKEIDEI-----LYE--EHRVLDH-GFIRVVDYM--------------------------------------GSDSAIVQAARVSY-------------GKGTKQ---------------------------INQDEVLIKYLM--RYHHTTPFE------------MCEI----------------------------------------------------------------------------------------------------------------KFHVK------------------------------------------------------------------------------------------------------------------------------LPIFIARQW-IRHRT-ANVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-HE------------FYIPEPE--------QVAKQSDNNKQGS--GE--AFDLDISKE-------------IIDSLINDSNLVYSHYNKFI--------------------------E-----------------QGLTREIARTNLT-LNYYTQFYWKVDLHN-LLH-FLKL-RAD--------KRAQHEIRVYAEVILDIV---KKWVPLV-HSAFVEYCLESACISR--TGLGIIRKLIRGENVTR-EES-NIGKREWEELMFILDKQPER-------------------------------------------------------------- Wolinella_succinogenes_CAE11216 ----------------------------------------------------------------------------------------MTVTLMQH---------------------------------------TSLTICAHAIRTCW-------------QSFEKS-------------------DG-----GGEKDRELIDRVG-NKNKHASTLE------------HLVY----------------------------------------------------------------------------------------------------------------TFYIQG-----------------------------------------------------------------------------------------------------------------------------ISRACLQEL-ARHRI-ASLSVKSSRYTLKELKAEEEF---KEGDWERAKRYLVET-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESEAVNLASLKALENLRQVL--------------------------L-----------------LGISNDMAKYCLP-ESYKTELTWTINARA-LQN-FLTL-RSS--------KSALWEIRKLAKTLHEAL---PKEHRYL-F--CLNQEG----------------------------------------------------------------------------------------------------------------- Xanthomonas_campestris_YP_239317 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTVESKLPRTLSIKFWRNSVISANVLQMSVGPVKTIT-----------------------------------------------------------------------------------------------------------------SMELC------------------------------------------------------------------------------------------------------------------------------YPRFIHAEL-MTHRV-FSRNASSSRAVPIDRMIRDIQENP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AMPNSW-----------MQNKPGMQGGD-VLGAREISE-----------------AKDAWIKACNDAVKHARVLK--------------------------D-----------------LGCHKQIVNRILE-PFAHIKVIVTATE---WDN-FFML-RLS--------DQAEPNIRELARKMIRAM---YRFEPQH-VGTGGLHAPYVNVEEM--LSQGVSVEDICMASAGRCARVSYLNHDGTKADVHQDILLARRLLADKHASVFEHQAFALSNSVATDMRSRNFYGWTQFRERVNL-------------------- delta_proteobacterium_EAT05671 ------------------------------------------------------------------------------------------MRIVPASFTILDELDQR----------------------------SMAQRIEVCGRLCY-------------KSEDKI--------------------------DAASCEPFIGKVM--EHGHNSVLE------------MAAL----------------------------------------------------------------------------------------------------------------TVRLWCETE---------------AMIDQLFAAQPKYLQIDRPVKKEKSLLISGTVRAFREMFMDWPQVKLVKAITATLAARYPLFFTDLAGKRGFLPQTGVEVEKVPLAEVEALPPELLARHRHLAVRFITNRAVTHEL-VRHRP-CSFLQESQRYCRYSQDKFG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NEVT------------FIKPLFF----------AEGSE----------------------------------EFQLWRHCMEETEKAYLQLL--------------------------------------------ATASPQAARTVLP-NSCKTEIIVYANLLE-WRH-ILRL-RSS--------RAAEPSMREVINPLLAVM---QQRYPAI-LDDIQAEQ------------------------------------------------------------------------------------------------------------------ uncultured_bacterium_AAR38374 ------------------------------------------------------------------MEAH-----LYN--AIPVLDH-GFIRVVDYM--------------------------------------GDDAAICQAARVSY-------------GKGTKS---------------------------VQNDEGLIRYLM--RHWHSTPFE------------MCEV----------------------------------------------------------------------------------------------------------------KLHVK------------------------------------------------------------------------------------------------------------------------------LPVFVARQW-IRHRT-ANVNEYSARYSIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-RE------------FYIPAPE--------HIAAQSVVNNQGR--GE--ALTGAEAAR-------------VLDILKTDSERSYDNYQAMI--------------------------SD--------DG-----QRGLARELARMNLP-ANIYTQWYWKVDLHN-LLH-FLRL-RAD--------AHAQYEIRVYADAICSVV---ADWVPFA-YAAFEDYRLGGATLSE--TALECVRRMLKGEAVTQ-ETS-GMSKGEWREFEQLL-------------------------------------------------------------------- ; END; [ The following blocks are output data for analysis step 5409 ] BEGIN TREES; TITLE Tb10817; LINK TAXA = TaxaForAnalysisStep5409; TREE Fig._3 = [&R] ((Dehalococcoides_sp_ZP_01138669,Dehalococcoides_ethenogenes_AAW39323),((((Thermosynechococcus_elongatus_NP_681946,Xanthomonas_campestris_YP_239317),(Syntrophobacter_fumaroxidans_ZP_00666252,((Syntrophomonas_wolfei_EAO22970,Moorella_thermoacetica_YP_431307),(Desulfotalea_psychrophila_CAG36957,delta_proteobacterium_EAT05671)))),((((Rhodococcus_sp_ABG98518,(Salinispora_tropica_ZP_01428560,(Frankia_sp_EAN1pec_ZP_00571881,(Frankia_sp_YP_482628,Frankia_alni_YP_715896)))),(Mycobacterium_sp_YP_639279,((Mycobacterium_vanbaalenii_ZP_01208056,Mycobacterium_flavescens_ZP_01194553),(Mycobacterium_leprae_CAC30465,(Mycobacterium_avium_NP_961799,(Mycobacterium_bovis_CAD94960,Mycobacterium_tuberculosis_ZP_00770421)))))),(Corynebacterium_jeikeium_CAI37294,(Corynebacterium_diphtheriae_CAE49993,(Corynebacterium_efficiens_BAB88822,Corynebacterium_glutamicum_CAF20313)))),((Streptomyces_phage_CAA07140,(Mycobacterium_phage_L5_CAA79424,(Mycobacterium_phage_NP_817637,(Mycobacteria_phage_AAC18488,Mycobacteriophage_Che12_YP_655630)))),(Rubrobacter_xylanophilus_YP_645362,(Rhodospirillum_rubrum_YP_427876,(Brevibacterium_linens_ZP_00380332,Thermobifida_fusca_AAZ55425)))))),(((Pyrococcus_horikoshii_NP_142699,(Thermococcus_kodakarensis_YP_183283,(Pyrococcus_abyssi_CAB50208,Pyrococcus_furiosus_AAL80664))),((Nanoarchaeum_equitans_AAR38870,(Aeropyrum_pernix_BAA81074,(Sulfolobus_acidocaldarius_AAY81629,(Acidianus_rodshaped_CAI44186,(Sulfolobus_tengchongensis_CAH04199,Sulfolobus_solfataricus_AAK40656))))),(Leptospira_interrogans_NP_711714,(Pyrobaculum_aerophilum_AAL63766,((Acidobacteria_bacterium_YP_593564,(((Candidatus_Protochlamydia_CAF22879,(Chlamydophila_pneumoniae_NP_224942,((Chlamydophila_felis_YP_514918,(Chlamydophila_caviae_AAP05750,Chlamydophila_abortus_CAH64419)),(Chlamydia_trachomatis_AAX50909,Chlamydia_muridarum_AAF39712)))),(Chloroflexus_aurantiacus_ZP_00768418,(Herpetosiphon_aurantiacus_ZP_01426098,Roseiflexus_sp_ZP_01355916))),((Picrophilus_torridus_AAT43321,Ferroplasma_acidarmanus_EAM93455),(Thermoplasma_acidophilum_NP_394882,Thermoplasma_volcanium_BAB60613)))),(Syntrophus_aciditrophicus_YP_462966,(Thermoanaerobacter_tengcongensis_AAM25376,Thermoanaerobacter_ethanolicus_ZP_00779467))))))),((((Clostridium_sp_ZP_01362803,((Clostridium_perfringens_ABG84971,Clostridium_tetani_NP_783134),(Caldicellulosiruptor_saccharolyticus_ZP_00884689,(Lawsonia_intracellularis_YP_595563,(Desulfovibrio_vulgaris_AAS96727,Desulfovibrio_desulfuricans_ABB39118))))),(Candidatus_Kuenenia_CAJ72160,(Desulfotomaculum_reducens_ZP_01150252,Pelotomaculum_thermopropionicum_GAA00501))),((Desulfitobacterium_hafniense_YP_516682,(((Bacillus_weihenstephanensis_ZP_01186649,(Bacillus_cereus_AAU16821,Bacillus_anthracis_AAT32922)),(Thiomicrospira_denitrificans_ABB43298,(Alvinella_pompejana_AAQ75147,(Wolinella_succinogenes_CAE11216,(((Campylobacter_upsaliensis_ZP_00371809,(Campylobacter_jejuni_ZP_01377925,(Campylobacter_lari_ZP_00369618,Campylobacter_coli_ZP_00368146))),(Campylobacter_fetus_ZP_01411215,(Campylobacter_curvus_ZP_01376670,Campylobacter_concisus_ZP_01375100))),(Helicobacter_hepaticus_AAP77717,(Helicobacter_pylori_NP_208323,Helicobacter_acinonychis_YP_665477))))))),(((((Cyanophage_PSSM4_YP_214756,((Cyanophage_PSSM2_YP_214554,(Prochlorococcus_marinus_subsp_pastoris_str_CCMP1986_NP_892362,(Prochlorococcus_marinus_str_MIT_9312_ABB49306,(Prochlorococcus_marinus_str_NATL2A_YP_292800,(Prochlorococcus_marinus_subsp_marinus_str_CCMP1375_NP_874667,Prochlorococcus_marinus_ZP_01006033))))),(Bacteriophage_Syn9_YP_717897,Bacteriophage_SPM2_CAF34258))),(Paramecium_bursaria_2CFA_B,(Synechocystis_sp_NP_440394,((Chlorobium_tepidum_AAM72779,(Chlorobium_chlorochromatii_ABB27663,((Pelodictyon_phaeoclathratiforme_ZP_00588145,Chlorobium_ferrooxidans_ZP_01385207),(Chlorobium_phaeobacteroides_ZP_00529968,(Chlorobium_limicola_ZP_00511556,(Prosthecochloris_vibrioformis_ZP_00660891,Pelodictyon_luteolum_ABB23254)))))),(Chlorobium_phaeobacteroides_BS1_ZP_00531300,Prosthecochloris_aestuarii_ZP_00590908))))),(Synechococcus_phage_AAL73301,Prochlorococcus_marinus_str_MIT_9313_NP_895377)),(Aquifex_aeolicus_AAC06847,(Deinococcus_geothermalis_YP_605490,((Gloeobacter_violaceus_BAC90262,(Thermus_thermophilus_BAD70919,((Treponema_denticola_NP_970925,(Treponema_pallidum_AAC65955,(Borrelia_hermsii_AAT68707,(Borrelia_burgdorferi_NP_045749,Borrelia_afzelii_ABH02196)))),((Dictyostelium_discoideum_XP_641335,Physarum_polycephalum_AAY87038),(Neorickettsia_sennetsu_YP_506060,(((Wolbachia_endosymbiont_ZP_01314862,Wolbachia_endosymbiont_strain_TRS_Brugia_malayi_AAW71329),((Ehrlichia_chaffeensis_ZP_00544975,(Ehrlichia_canis_AAZ68718,Ehrlichia_ruminantium_CAI27208)),(Anaplasma_marginale_Q5PBM3,Anaplasma_phagocytophilum_YP_504787))),((Rickettsia_bellii_ZP_01380446,(Rickettsia_canadensis_ZP_01347808,(Rickettsia_conorii_AAL02943,((Rickettsia_prowazekii_CAA14762,Rickettsia_typhi_AAU03772),(Rickettsia_akari_ZP_00340125,Rickettsia_felis_AAY61342))))),(Candidatus_Pelagibacter_ZP_01264826,((Jannaschia_sp_YP_509033,(Paracoccus_denitrificans_ZP_00633170,(Oceanicola_granulosus_ZP_01156549,((Roseovarius_sp_ZP_01038219,Roseovarius_nubinhibens_ZP_00960246),(Silicibacter_pomeroyi_AAV94565,(Sulfitobacter_sp_ZP_00955358,uncultured_bacterium_AAR38374)))))),(Gluconobacter_oxydans_AAW61178,Acidiphilium_cryptum_ZP_01145406)))))))))),(Thermotoga_maritima_1O2B_D,(Magnetococcus_sp_EAN29948,(Tropheryma_whipplei_NP_787744,(Acidothermus_cellulolyticus_ZP_01137552,((Mycobacterium_phage_Bxz1_NP_818164,Mycobacteriophage_Catera_YP_656098),(Streptomyces_coelicolor_CAA20294,Streptomyces_avermitilis_NP_823693)))))))))),((Halovirus_HF1_AAO61355,(Haloarcula_marismortui_AAV46077,(Halobacterium_sp_AAG19665,Halobacterium_salinarum_AAK00648))),((Synechococcus_sp_JA23Ba_213_YP_478001,Synechococcus_sp_JA33Ab_YP_473724),((Nostoc_punctiforme_ZP_00106512,(Anabaena_variabilis_YP_323423,Nostoc_sp_BAB72473)),(Synechococcus_elongatus_YP_171214,(Synechococcus_sp_WH_5701_ZP_01084768,((Synechococcus_sp_WH_8102_NP_896374,Synechococcus_sp_ABB34049),(Synechococcus_sp_WH_7805_ZP_01123511,(Synechococcus_sp_RS9917_ZP_01080929,(Synechococcus_sp_CC9311_YP_729554,Synechococcus_sp_CC9902_ABB27029)))))))))))),(Anaeromyxobacter_dehalogenans_YP_464350,Carboxydothermus_hydrogenoformans_ABB14922))),(((Geobacter_sp_ZP_01389528,Geobacter_uraniumreducens_ZP_01142218),(Geobacter_sulfurreducens_AAR36497,Geobacter_metallireducens_ABB30621)),(Desulfuromonas_acetoxidans_ZP_01311759,Pelobacter_carbinolicus_YP_358099)))))); [! TreeBASE tree URI: http://purl.org/phylo/treebase/phylows/tree/TB2:Tr6172] END;