#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on September 19, 2025; 9:50 GMT TreeBASE (cc) 1994-2008 Study reference: D'angelo M.E., Dunstone M.A., Whisstock J.C., Trapani J.A., & Bird P.I. 2012. Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi. BMC Evolutionary Biology, 12(1). TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S12411] [ The following blocks are input data for analysis step 8694 ] BEGIN TAXA; TITLE TaxaForAnalysisStep8694; DIMENSIONS NTAX=39; TAXLABELS Carassius_auratus_langsdorfii_PRF1.1 Carassius_auratus_langsdorfii_PRF1.2 Carassius_auratus_langsdorfii_PRF1.3 Ctenopharyngodon_idella_PRF1.1 Ctenopharyngodon_idella_PRF1.2 Danio_rerio_PRF1.1 Danio_rerio_PRF1.2 Danio_rerio_PRF1.3 Danio_rerio_PRF1.4 Danio_rerio_PRF1.5 Danio_rerio_PRF1.6 Danio_rerio_PRF1.7 Danio_rerio_PRF1.8 Gasterosteus_aculeatus_PRF1.1 Gasterosteus_aculeatus_PRF1.2 Gasterosteus_aculeatus_PRF1.3 Gasterosteus_aculeatus_PRF1.4 Gasterosteus_aculeatus_PRF1.5 Gasterosteus_aculeatus_PRF1.6 Homo_sapiens_PRF1 Oncorhynchus_mykiss_PRF1 Oryzias_latipes_PRF1.1 Oryzias_latipes_PRF1.2 Oryzias_latipes_PRF1.3 Oryzias_latipes_PRF1.4 Oryzias_latipes_PRF1.5 Oryzias_latipes_PRF1.6 Oryzias_latipes_PRF1.8 Paralichthys_olivaceus_PRF1 Salmo_salar_PRF1.1 Salmo_salar_PRF1.2 Takifugu_rubripes_PRF1.1 Takifugu_rubripes_PRF1.2 Takifugu_rubripes_PRF1.3 Takifugu_rubripes_PRF1.5 Takifugu_rubripes_PRF1.6 Tetraodon_nigroviridis_PRF1.1 Tetraodon_nigroviridis_PRF1.2 Tetraodon_nigroviridis_PRF1.3 ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M11729] TITLE Fish_perforin; LINK TAXA = TaxaForAnalysisStep8694; DIMENSIONS NCHAR=439; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 ] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] Carassius_auratus_langsdorfii_PRF1.1 SCFLGKEAECQDAD-FVPGSDLAGEGFDITKMQHLGTFVIDMSTCNLCKNPFMQKKQKLPVSVIYWRATQK-CKRSLSSSVYESSESLVSSSTSSIENNWKVGLGVSKISLMMAGTNSKLAEYSMAKTKKDTFSFIKQSTSCEYYRYSISSRASLHHELSNEFTSLPESYLSLVEKFGTHYIVQVKLGGAVQSVTSVRNCIATLQDLSIDEVKTCLDVEVSTAARHCKQSKDKKLSKHSFANNFSDRLTEITGGHALLFSDWLATVPEKPDVISFKLKPLHMLLPVKPKYKQLRRAIRDYILQRALMKCHNIAGVKANCCPAQRGLAQISVTVMKATGLWGDYFSQTDGYVKVLRNQFLGETPVIWNQNSPTWNWKFGLDSFGGLRLEVWDLLGACNIQLKAGVKSNFCRLNHGLLYYKTSVTCAPSLAGSSCTEYVSS Carassius_auratus_langsdorfii_PRF1.2 CCETVPSTECEKPS-FVPGHNLVGEGFDIVQMKTTGAFVVDVRNCTVCENKLLNEKQKLPASVVDWRVKVQ-CRRSVGAKIYESASSVLKDTTNSASASWKIGLSPMAGGVAVGGTHSKSARFAKSHASQDKYSFTSHTFSCRYYSFRLHARPPVTKEFLGSITALPGAYNHFISIYGTHFLRRVDLGGRVHSTTAVKTCQVSMKGLSVHDVSNCLSAEASAQAGYCKGKSQKLERGNSFSGTFSDRVTEILGGNDILFSPWLKSLKKIPGVVSYTLSSLHMLVKNDARRASLQAAISKYITKSAISTCSGHQRIDSNCCPSNPGVATLTVTVLSGAGLWGDYFSKTDGYVKVFYGSRAYETPVIWNNNFPQWNYNINFETVTPLRFEVWDLLGKSSTVPQKGMNQKKFKLKHGSFLISYSAQCGPSLTGSFCEKYAPT Carassius_auratus_langsdorfii_PRF1.3 EGDIGSSKECKNAP-FVPGHNLAGEGFDIVTMERKGSYVIDTETCKLHKNTFMNGKQKLPAAVVDWRPLPK-CSMKVSSQIYESSEALVKESSSAVSAGWNIGLDVYAGGYVVGSTHSSESKFAMQKSKEDKYSFTKHEVECSFYRYRVAAKPPLQAEFLEAVKSLPVAYRNLISTYGTHYTTSVKLGGEMKAITAIKSCQAAMMGLTDTAVKDCLDVEASSKTNLCEKLKRKMHTSVKFSSMFSERQMEIIGGEDLLFSGWVKSLKSLPDVLHYSLKPLHFLLSAKPARKGLKKAVEKYITENALKKCESSQMITSNCCPAAKGLATLKVYSLRARGLYGDKFTQTDGTVTVTYDGKYMRTQTINNNDNPSWPETFYFGPIKKITFAVYDFLGSCSFYLRSGVVRDACAFTYGTFYFNYKVECAPSLQGHKCDEYRPS Ctenopharyngodon_idella_PRF1.1 ACFRGKEAECQDAD-FAPGSDLAGEGFDITKMQRLGTFVIDMSTCNLCKNPFMNNKQKLPLSVVYWRATQK-CSMSLSSSIYESSESLVSSSTSSVENNWKAGLGMNKMSLMFAGTNSRLAVYSMRKTKKDKYSFIKQSASCGYYSYRISSHSPIHQELNLDFTNLPESYLSLVEKFGTHYIVQVKLGGAVQSVTSVQQCEASLQDLSTDEVKTCLDVEASTAYRHCKQTEDKKLSKHSFAHRFSDRLTEITGGHALLFSAWLSSVPGKPDVISFSLKPLHMLMPVKPKYGQLRRAIRDYILQRALWKCHNSPGVKANCCPTQRGIAQITVIVKKATGLWGDYFTQTDGYVKVLRNHFLGETPVIWNRNSPTWNWKFDLGSFGGLRLEVWDLLGACNIQLNNGKKSNFCSLNHGMLYYKTSVTCGPSLTGSLCTEYVGF Ctenopharyngodon_idella_PRF1.2 SCAKGKPNECAEAS-FAPGSNLAGEGYDVTKMQRKGAFVINTDSCTLCTNPYMDRKQRLPISVVDWRPSQK-CNIKISSSLYQSSEDLVSSSTSSIENNWAANLGKNSGSFMVAGTNSKLAEYSMEKTKKDKFNFASQSISCAFYSYRVSNKPVLHPEFKRSVKELPPRFYKFINTYGTHYITKVTLGGSVQSVTSIRQCETALQGLSVDEVKTCLDVEASAETKHCNEDKDKTEHKSSFSSRFNDRLTDIIGGHELLFSGWLASLPQNPDVISYSLESLHELISSKPVRKHLRQAIHDYILEKSLWRCHNNPGITPDCCPSQRGLSRVKVTIVRAQGLWGDQTTATDGYVKVFDKHQVGRTDMITNNNSPYWGRTFDLGDVEKMKLEVWDLLGTCEVPIKAGQNDNFCNLNHGVLFYKTEVTCAPSLSGTYCSKYVGS Danio_rerio_PRF1.1 SCTKGKPKECEEAT-FAPGSNLAGEGYDVIKMQRKGAFVINTDSCTLCKNPYMDGLQKLPLSVVDWRTSQK-CTVKVSSSLYHSSEDLVSSSASSIENNWGASLGKTTGSIVLAGSKSKLAEYSMEKTKKDKFNFASQSISCAYYSYRVSNKPVLHPEFKRSVKELPPRFYKFINTFGTHYITKVTLGGNVHSVTSIRQCETALQGLSTDEVKACLDLEANAESKHCSQNQDKTESKTSFSSRFNDRLTEVTGGHELLFSGWLASLPQNPDVISHSLESLHELIPTKPVRKHMRQAIHDYILENSLWRCHNKPGITPDCCPSKRGLSRVQVTVVKAQDLWGDTTTATDGYVKVFDKNKIGSTNMIPNNNSPYWGQTFDLGDVDNIKLEVWDLLGTCQVAIKVQSQTYNCSLNHGLLYYNTKVTCAPGLAGTYCEKYVGS Danio_rerio_PRF1.2 EVEIGTSKECENAH-FVPGYNLAGEGFDVVTLERKGTYVINTETCNMRTNQYMNGKQKLPAAVDFWRTLPK-CSMKVSSQIFESSEAVVEESSSAISGNWKADLSVQLSGATVGGTHSREAKFAMQKSKQDKYSFTKHQVECNFYRYHVVQKPPLHAEFLQAIKLLPFAYRSLISTYGTHYTTSVMLGGHMKAITAIKTCEASIGGLSDTAIKDCLDVEASAEARLCRELKQKLGTNLKMSSKFSERQTEIIGGNDLLFSGWLESLKSVPDVVQYTLKPLHFLLSEKPARKGLKKAVEEYITENALRNCESSKIMKSNCCPTEKGLATLKVYNLRANGLFGDTLTQTDGYVEIKHQGQNKRTQTIVDNDNPRWSETFNFGHISTLTLEVYDHLGTCSVKVSSGVVNDGCALDHGTLFFSYEVKCAPSLQGRHCDEHKPS Danio_rerio_PRF1.3 GCESVASTECEKLP-FVPGHNLVGEGFNIVQMKTTGAFVVDVRNCTACDNKLLNQKQKLPVSVIDWRIKVQ-CRRSLSAKVYESASSVMEDTTSAASLSWKVGLSPMVAGVAVGGTHSKSARFARSHASKDKFSYTSHTFSCRYYSFRLHARPPLTKEFAGSISSLPSAYNHFISIYGTHFLRRVDLGGRVKSTTAVRTCQVSMKGLSANDVSNCLSAEASGQTAYCKSKQKQLERANSFSATFSDRVTDILGGNDILFTPWLGSLKKIPGVVSYTLSSLHMLVRNDARRSSLQQAISKYITKYAISTCNGHVNVNSNCCPNKPGVATLTVTVVSAAGLWGDVFSKTDGYVKVFYGSHTAQTPVIWNNNFPQWNFRAEFGTVASLQFQVWDLLGKGAVVPEKGVNVPKFGFKHGSLMISYSATCGPSLQGSFCEIYAPT Danio_rerio_PRF1.4 ACFLGKQAECQDAS-FVPGSDLAGEGFDITKMQRLGTFVFDMSTCNLCKNPFMQNKQKLPVSAVYWRASQK-CTMSLSSSVYESSESLVSSSTSSIENNWKTGLGLSKVSLMVAGTNSRLSDYSMSKTKKDKFSFIKQSASCVYYSYRIASSAPLHHELRDDFSNLPESYLSLVEKFGTHYIIQVKLGGGVQSVTSVKQCMATLQDLSVDEVKTCLDVEASTAYRHCKQSQDKKLSAHSFANSFSDRLTEITGGHALLFSAWLSSVPQQPDVISFSLKPLHMLMPAKPKRDQLRRAIHDYVLQKALLKCHNNPAVKANCCPAQRGIAQITVTVMRATGLFGDYFTWTDGYVKVFRNQFLGETPVIWNQNSPKWNWRFDLGSFGGLKLEVWDLLGTCNIQLKAGVKNDFCRLNHGLLYFKTSVTCGPSLAGSSCTEYVGS Danio_rerio_PRF1.5 ACHTGSQTECEKAP-FVPGYNLAGEGFDVVKMRRKGAFLINVKTCTICKNRFQGGMQKLPSAVLDWRPFSR-CSKQLSSALHHSVDSLMKSSTSLVNNNWEMDLSDDMGKVIFGGSRSDIAQFAHSQNTMDKATFALHEISCTYYSYRITDNPELSAEFSKHLQKLPPLYRRTIETYGTHYIRQVHLGGRVRRVTAFRTCLATLKGFSETDIKNCLNVELKSLSNKCSQILKDN-LSMGFYQGFMTHKTEVLGGEDLVLSQWMMSLHNNPDVISYAIFPLHHLVADPEVSSNLKIAVTEYIEENMISVCSQTPNLDHNCCPMRAGRGTLIVLVQRAAGLKADLFTRTDGYVKVWYNFMYEETEVVMDNNDPEWNISYDLGSVHELIFEVWDMVGRCVVSPERGIHSHSCKLKRGVLYFTYKASCDAHLTGPRCSRYSPK Danio_rerio_PRF1.6 ACHTGSQAECEKAP-FVPGYNLAGEGFDLVKMRRKGAFLINVKTCTICKNRFHGDMQKLPSAVLDWRIFST--TAQPSTALHHSVDSLMKSSTSLINNNWKVDLRDDTGKVIFGGSRSDIAQFAHSQSAKDKTTFALHEISCTYYSYRLRDHPELSTEFSKHLQTLPHLYQKMIETYGTHYIRQVHLGGRVRWVTAFRTCLATLKGFSEIDIKHCLNMDFMSFSNKCSKILVEE-MGMGFYQTFMTHKTEVLGGEELVLNQWRKSLHDNPDVISYAIFPLHHLVADPEVSANLKRAVTQYIEENAISICSKMSNLDQNCCPLRAGRGTLVVFMMGATGMNEDYFSSSDGYVKAWYNGIYKETEVILDNNDPDWNTNFNFGSVHQLKFEVWDFVGECVISPESGMHIHRCKLQRGFFYFIYRALCDDHLTGPRCSRYSPE Danio_rerio_PRF1.7 EVEIGTLKECENAH-FVPGYNLAGEGFDVVTLERKGTYVINTETCNMRTNQYMNGKQKLPAAVDFWRTLPK-CSMKVSGQIFESSEAVVEESSSAISGDWKADLSVKLSGATVGGTHSREAKFAMQKSKRDKYSFTKHQVECNFYRYHVVQKPPLHAEFLQAIKLLPFAYRSLISTYGTHYTTSVMLGGHMKAITAIKTCEASIGGLSDTAIKDCLDVEASAEARLCRELKQKLGTNLKMSSKFSERQTEIIGGKDLLFSGWLESLKSVPDVVQYTLKPLHFLLSDKPARKGLKKAVEEYIIENALRKCESSRIMKTNCCPTEKGLATLKVYNLRANGLYGDTWTQTDGYVEVRHQGQNKRTQIIDDNDNPRWSESFNFGHISTLTFEVYDHLGTCSVKVSSGVVNDGCALNHGTLFFSYEVKCAPSLQGPQCDEHKPS Danio_rerio_PRF1.8 EDEIGTSKECEDAP-FVPRYNLAGEGFDVVTLERKGTYVINMETCALVENDYLPGKQKLPVAVKFWRTLPK-CSMKVSSQIFESSEAVVNDSSSALSASWKVGIDVKAVGAAVGSTHSREAKFAMTKSKEDKYSFTKHQVECSFYRYNVAENPPLHAEFLEAIKSLPDAYRSLIYTYGTHYTTNVKLGGQIKAITAIKTCQAAVSGLTDTAIKDCLDVEASAEAHFCKEQQKKMGTNQKFSSMFSERQTDIIGGNHLLFSGWLESLKSLPDVVQYSLKPLHFLLSAKPARKGLKKAVEEYIIENALMKCESSQVIKSNCCPAENGLATLKVYNLRANGLYGDVRTQTDGTVLVKYGKTIKRTETIDNNDNPRWRDTFDFGPVERLCFEVYDLLGKCSFKLRSGVVTDACVFNYGTFFFTYEVKCAPSLQGPQCNEHKPS Gasterosteus_aculeatus_PRF1.1 SCTDGTPSQCAGAE-LAPGTNMAGEGFDITKMERKGSFVLNMSTCTLCTNPYLENKQKLPLSVVNWRPMQS-CSMKVGTALHQSSESLVNSLTSSVENNWKVNLDGRSASVMLAGTNSKVAEYSMEKSKKDKFSFASHSFSCEFYSYGVSSNPGLSGEFKKALKKLPQRFYKLIDNFGTHYITKVKMGGSVRSVTSIRQCQASLNGISSQEAEMCLEAEASTETKHCQKDINKRERQESFSSIFNDRFTETKGGHDLLFSSWLNTLPQNPDIVSCSLDSLHELLPVNPVRKNMRAAISHYILEKGLWRCHNDPSVNRDCCPTRKGMARVIITVQRAHGLWGDHTSATDGYVKVFLGDVPQRTPVIMNNNSPHWAMVMDLGSQKNVRFEVWDLLGTCNQVLQAGVKEEVCALQHGQLFYKVDVKCAPNLSGATCTDYKPS Gasterosteus_aculeatus_PRF1.2 VPFIGSPQQCEKAR-FVPGYNLGGEGFDIVKMERKGAYVIDTETCRMYNNNFMNGSQKVPAAVLDWRVLPK-CSLKVSSLVYNSAETLVNDSTSAVSNDWKIGLKTVTLGVGFGGSHSKESTFAMQKSKEDRYTFVRHSVDCTLYNYRMTSSPPLSQDFKSAVNSLPSNYRSLIDTYGTHFITQVSLGGQIKAITSVKTCQASMQGLSSTEVANCLFVEASARYQYCKSKKQKLGFGQSFSGTFHERSADVIGGDDILFNGWQQSLQTLPDVVKYSIDPLHTLLPIDSARAGLKQEVEKYIVDNAVLKCDSNSNIQHNCCPAGKGLATLKVFKLYADGLYGDKWTQTDGSVEVRYGDQTKRTAIISNNDYPRWTETFQFASINKLQFTVYDLLGECSFGLRKGKHRDSCMFDYGTFFFSYEVECAPSLSGDECQDYIPS Gasterosteus_aculeatus_PRF1.3 VRFIGSPQQCAKAR-FVPGYNLGGEGFDIVKMERKGAYVIDTETCRLFNNNFMKGRQKVPAAVVDWRVLPK-CSLKVSSLVYNSAETLVNDSTSAVSNDWKVDLTSVTLGVGLGGSHSKESTFAMQKSKEDRYTFVRHSVDCTLYNYRMTSNPPLSQDFKSAVNSLPLKYRSLIDTYGTHFITQVSLGGKIKAITSVKTCQASMQGLSSTDVADCLSVEASAMFNHCESEKKKLGSSQSFSGTFRERSADVIGGDDILFNGWQRSLQSLPDVVKYSIKSLHTLLPIGAARAGLKQEEEKYIVDNAVLKCNSNSNIKHNCCPAGKGFATLKVFRLYADGLYGDKWTQTDGSVEVRYGDQTKRTAIISNNDYPRWSETFQFGNINKLQFTVYDSLGKCSFGLHKGKHRDSCMFDYGTFFFSYEVECAPSLSGDECQDYIPS Gasterosteus_aculeatus_PRF1.4 VRFIGSPQQCAKAR-FVPGYNLGGEGFDIVKMERKGAYVIDTETCRMFNNNFMKGSQKVPAAVVDWRVLPK-CSLKVSSLVYNSAETLVNDSTSAVSNDWKVDLTSVTLGVGLGGSHSKESTFAMQKSKEDHYTFVRHSVDCTLYNYRMTSNPPLSQDFKSAVNSLPLEYRSLIDTYGTHFITQVSLGGKIKAITSVKTCQASMQGLSSTDVADCLSVEASAMFNHCESEKKKLGSSQSFSGTFRERSADVIGGDDILFNGWQRSLQSLPDVVKYSIKSLHTLLPIGAARAGLKQEEEKYIVDNAVLKCNSNSNIKHNCCPAGKGFATLKVFKLYANGLYGDTCTRTDGSVEVRYGDQTKRTAIIRNNDYPRWSETFQFGNINKLQFTVYDRLGKCSFGLLKGKHINSCMFNYGTFFFSYEVECAPSLSGDECQDYIPS Gasterosteus_aculeatus_PRF1.5 GCRVGSGAECEKAP-FVPGHNLAGEGFDVVRMRRTGAYVINVKTCTLCPNRFQEGVQRLPAAVLDWRPLSR-CSKQLSSALHHSVDSLLRSSNSLVNNNWGMGLSENIGKALLGGSRSDLAKFARSQHSVDKATFATHEISCTYYSYRLADHPQLSAEFLKHLKRLPALYRRLIDTYGTHYIHQVHLGGKVRRITAFRTCLATLKGFSESDIKNCLNFELRSFSNKCEDLLKGN-MSMGFYQGFMTHKIEVIGGEDILYQEWMSSLHENPDVVSYAIFPLHHLVEDSRVSANLKSTITEYIKDNQLQECSPTPNLDHNCCPLRAGRGTLGLEIHRAAGLRADSITKTDAYVKIFYNGVYEETETVMNDNDPLWNVTYDFGSVQALRFEVWDVAGRCVVFPERGTHALSCQLSKGVLYFTYTVKCDAHLTGYRCGRYSPN Gasterosteus_aculeatus_PRF1.6 VPFLGSPQQCEKAR-FVPGYNLGGEGFDIVKMERKGAYVIDTETCRMYNNNFMNGSQKVPAAVLDWRVLPK-CSLKVSSLVYNSAETLVNDSTSAVSNDWKIGLKTVTLGVGFGGSHSKESTFAMQKSKEDRYTFVRHSVDCTLYNYRMTTNPPLSQDFKSAVNSLPSNYRSLIDTYGTHFITQVSLGGQIKAITSVKTCQASMQGLSSTEVANCLFVEASARYQHCKSKKKKLGFGQSFSGTFHERSADVIGGDDILFNGWQQSLQTLPDVVKYSIDPLHTLLPIDSARAGLKQEVEKYIVDNAVLKCDSNSNIQHNCCPAGKGLATLKVFKLYADGLYGDKWTQTDGSVEVRYGDQTKRTAIISNNDYPRWTETFQFASINKLQFTVYDLLGECSFGLRKGKHRDSCMFDYGTFFFSYEVECAPSLSGDECQDYIPS Homo_sapiens_PRF1 PCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPVDTQTCTLCENALQEGLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARDAARSIRNDWKVGLDTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHDLLFGIWVNSLPGSPGLVDYTLEPLHVLLDSQPRREALRRALSQYLTDRARWRCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVGPLRLQVWDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQ Oncorhynchus_mykiss_PRF1 SCTIGSANECKEAE-FAPGTNLAGEGFDITKMKRKGAFVIDMNTCTLCKNPYLEGQQRLPLAVVDWRPNHQ-CSMKVSSKLHRSSESLVSSSGSSVENNWQVNLESKSGKIMLAGTNSKLAEYSMEKTKSDKFSFTSHSVSCGYYSYRVSGQPKLHREFKTAVKNLPQRYYKLIDNFGTHYITKVSLGGTVQSVTSIKQCQASLQGLSAEEVKMCLDVEASTEFKHCQEDKSKTESKASFSSVFNDRFTEVKGGHELLFSAWLDSLPHYPDIVSYSLESLHELLPTTPARKHLRKAISDYILEKALWKCHNNPGVSADCCPTRK?LARVVITVQRGANLWGDHTTATDGYVKVAFAGTIGRTTVIYNNNNPSWAMSYDLGTVKKLRFEVWDLLGECEKELTAGVKEDLCNLQHGQMYYKWEAVCAPSLGGSACMDYVPS Oryzias_latipes_PRF1.1 MCTDGTPKECQEAE-FAPGSNLAGEGFDITSMERKGAFVLDMNACTLCTNPYMDNRQKLPLSVVDWRATHS-CSSKVSSQIFKSSESLVESTTSSVENNWKVGLSGAISNLMLAGSHSKVAGYSMQKTKSDKFSFTTQGLSCEYYSYRVSKAPTLQKDFLDSVKQLPDNYYHLIDTFGTHYITKVKMGGKVQAVTSIRECLAHLEGIEVNEAEMCLRVEASIEVQNCQAKKDKSGRKIAFSSYFNDRFTEVRGGQDLIFSAWLNSVPQNPDIISYSLDSVHELFPKSCMRENLRSAITHYILEKGLLKCHNNPAVTPDCCPAEKSKARVIITVVRASGLWGDYFTATDAYVKVFIGKLVGRTPVIANNNNPQWNMAIDLGTQQKLKFEVWDLLGTCERALTSGNKRGVCALNHGELFFNWKVECTPNLSGSYCQNYQSS Oryzias_latipes_PRF1.2 MCTDGTPKECLEAE-FAPGSNLAGEGFDITSMERKGAFVLDTNACTLCTNPYMDNRQKLPLSVVDWRATHS-CSSKVSSQIFKSSESLVESTTSSVQNDWKVGLNPFKANLMLAGSHSKVAGYSMEKTKSDKFSFTTQGLSCEYYSYRVSKAPTLQKDFLDSVKQLPDNYYHLIDTFGTHYITKVKMGGKVQAVTSIRECEAHLNGIEVNEVEMCLRVEASSEVQHCQGKKDKLGRKITFSSYFNDRFMEVKGGQDLIFSAWLNSVPQNPDILSYSLDSLHELFPKSPMRQNLRSAITHYILEKGLMKCHNNPAVTPDCCPAQRGMARVIITVVRASKLRGDDFTATDAYVKVFIGKLVGRTPIIANDDNPHWNMKLDLGTQVKLKFEVWDLLGTCEQDLTSGTKRGVCALNRGELFFNWKVECAPSLSGSYCQTYQSS Oryzias_latipes_PRF1.3 MCTDGTPQECQQAE-FVPGSNLAGEGFDITSMERKGAFVLDMNACTLCTNPYMDNRQKLPLSVVDWRAKHS-CSSKVSSQIFKSSESLVESTTSSVQNDWKVGLNPFKANLMLAGSHSKVAGYSMEKTKSDKFSFTTQGLSCEYYSYRVSKAPTLQKDFLDSVKQLPDNYYHLIDTFGTHYITKVKMGGKVQAVTSIRECEAHLNGIEVNEVDMCLRVEASSEAEQCQGKKDKLGRKITFSSYFTDRFMEVKGGQDLIFSAWLNSVPQNPDILSYSLDSVHELIPKSPMRQNLRSAITHYILEKGLMKCHNNPAVTPDCCPAEKSEARVIITVVRASKLWGDYSSGTDAYVKVFFGKLVGRTPIIADDDNPHWNMKLDLGTQVKLKFEVWDLLGTCERALTSGTKRGVCALNHGELFFNWKVECTPNLSGSYCQNYQSS Oryzias_latipes_PRF1.4 TCTDGKPKECQEAE-FVPGSNLAGEGFDITKMERKGAFVLDMNACTLCSNPYMEMKQKLPLSVVDWRAKHS-CSGKVSSKLHKSSESLVESSTSSVENNWKVDLEDKSGSVMLAGTNSKLAEYAMEKTKNDRFSFSTNSITCEYYSYRVSSHPRMHQEFRKAVRELPKIFNKVIEKFGTHYITKVKLGGKVKTVTSIRQCEASLQGLSAEEVQMCLEAEASTEMKHCKKDSNKLDNKQAFSDFFTDRLTEIRGGHDLLFSAWLSSVPQYPDILSYSLDSLHDLLSPKPVRKNLRSAIRHYILEKGLWKCHNEPAVNSDCCPTRKGMARVIITVQRALDLWGDHSTPTDGFVKVLVNNQVHRSPVINNNNNPHWENIVDLGSMNIIRFEVWDLLGGCEEILTAGTKEDVCTLQHGRFYYKWEVKCAPSLGGKSCTDYEAS Oryzias_latipes_PRF1.5 SCRIGNSSECDSAS-FVPGHNLVGEGFDVVRLQRKGAHVIDVKSCTLCSNSLQGNLQKLPVSVIDWRAFSH-CSADIYSSSHTSVSSLIETYSAQDSNDWKVGLEYVSANLEVGGTRSSAYNFGSQRTSVDRHFFSIHRVTCSHYSYRSSVRPPLSSEFMKDVGRLPAQYEELIHIYGTHYIRQVYLGGRLRRVTATRTCLASLNGLSSNEAHSCLSQGISSSHKSCKQVLENQGTSTTYGSGFHQHYTDVSGGNEFSVSHWMASLKDHPDIVSYSLRPMYDLMPNEAQRAGMKAAIEKYLGDNAVKRNGYTPNLATNCCPMQARRGTLEVTIIRGWNLKGDLTGKTESYAKLWFGPHDRRTHMIR-SNDPRWNAYYNLGKVPGLKVEVWDLLGTCTKSVIQGTHRFTCPAKKGGFEVQYTLTCDPHLTGDKCERYKPS Oryzias_latipes_PRF1.6 ACRIGTGPECEKAP-FVPGHNLAGEGFDVVRLRRTGAYVINVKTCTLCPNRFQKGIQRLPASVLDWRPFSR-CSKQLSSALHHSVESLLRSSNSLVNNNWGLGLSESIGHGVLGGSRSDLAKFASSQHSVDKATFALHEISCTYYSFRLADHPQLSSEFIKHLRKLPASYRRLIDTYGTHYIHQVHLGGKVRRITAFRTCLATLKGFSETEIKNCLNVELRSFSNKCDGLLKGN-MSMGFYQGFMTHKIEVIGGEDILYQQWMNSLHENPDVVSYAIFPLHHLVEDSRVSANLRSVVTEYIKENQLQECSPTPNLDHNCCPLRAGRGTLTVEIHRGAGLRADTFTKTDAFVKIFYSGMYEETETVMDNNDPVWNATYEFGSVQALRFEVWDMAGTCVVYPERGRHSLGCKLRKGVFYFTYTITCDAHLTGYRCGRYSPN Oryzias_latipes_PRF1.8 TCTDGTPQECQDAG-FVPGSNLAGEGFDITSMERKGAFVLDMNSCTLCTNPYMDNRQKLPLSVVDWRATHS-CSSKVSSQIFKSSESLVESTTSSVQNDWKVGLNPFKANLMLAGSHSKVAGYSMEKTKSDKFSFTTQGLSCEYYSYRISKTPTLQKDFLDSVKQLPNNYYHLIDTFGTHYITKVKMGGKVQAVTSIRECEAHLDGIEVNEAEMCLRVEASSEVQHCQGKKDKLGRKITFSSYFNDRFMEVKGGQDLIFSAWLNSVPQNPDTLSYSLDSLHELIPKSPMRENLCSAITHYILEKGLLKCHNNPAVTPDCCPAQRGMAR-IITVLGGSYLYGDDFTATDAYVKVFTGKQVFRTDTIDNDDFPKWNMKLDLGSQ-KLKFEVWDLLGSCERSLTSGTNSDACSLDYGELYFEWKVECAPNLSGSYCQTYQSS Paralichthys_olivaceus_PRF1 SCTDGKPMQCQNAE-YAPGANLAGEGFDITKLERKGAFVIDMNTCTLCTNPYMENWQKLPLSVLDWRAKQS-CSNKVASKLHRSSESLVSSSSASIENNWQINLDPRSGSLMLAGAHSKVAEYSMEKTKKDKFSFTSQSISCEYYSYRVSNTPKLHKEFKKAVKQLPQQFYNLIDNFGTHYITKVKLGGSVESVTSIRQCQASLEGLSVEEVQMCLEAEASAQNKFCKRDANKMESKSSFSSHFGDRFTEIKGGHDLLFSAWLTTLPEHPDILSYSLKSLHELLPRNPLQKNLRSAISHYILEKGLLRCHNDPAVNQNCCPTRVGMAQVIITVQRATGLWGDHTTSTDGYVKVSLDTLVQQSPVINNNNNPHWAMVVPLGSQPKVRFEVWDLLGACEQVLSAGVKEEMCQLQHGLLYYKWEVRCAPSLSGNTCTEYKSS Salmo_salar_PRF1.1 SCIIGSANECKEAE-FAPGTNLAGEGFDITKMKRKGAFVIDMNTCTLCENPYLEGKQRLPLAVVDWRPNHQ-CSMKVSSKLHRSSESLVSSSSSSVENNWQVNLESKSGKFMLAGTNSKLAEYSMEKTKSDKFSFTSHSVSCGYYSYRVSGQPKLHREFKTAVKNLPQRYYKLIDNFGTHYITKVSLGGTVQSVTSIMQCQASLQGLSAEEVKMCLDVEATTEFKHCQEDKSKTESKASFSSVFNDRFTEVKGGHELLFSAWLDSLPRYPDIVSYSLESLHELLPTTPARKHLRKAISDYILENALWKCHNNPGVSADCCPTRKGLARVIITVQRGANLWGDHTTATDGYVKVAFAGTIGRTRVIYNNNNPSWAMSYDLGTVKKLRFEVWDLLGECEKELTAGVKEDLCNLQHGQMFYKWEVVCAPSLGGSACMDYVPS Salmo_salar_PRF1.2 SCTTGRPAECKAAL-SAPGTNLAGEGFDVVTMERKQAYVIDVDTCTLCVNPFMDRAQRLPAAVVDWRPSQK-CNMKLASMVYDSSEAFVSSSQTEVDVSWKIGLDQAKGSVMVGGTHSRAAKTVMSQSKKDKYSFIKQDIHCSYYSYRLLDDPPLHPEFSRSLGLLPVDYRRFLDNFGTHFIKKVLLGGRVKSVTSLRVCQAALSGYNENEVKDCLEAEASTETKFCKKDLKKRDTKDRFSSTFQERFTEVVGGEDLLFSQWASSLKTIPDVINYSLHPLHLLVKQGSKRAGLKKAVEDYILGHALVKCKASKEMTSQCCPQEKGLAHLTVTVKYARDLWGDTTSETDGLVKVIMDNEARQTKVIHNKNNPVWNSFYDFGFVSELKFEVYDLLGNCSTRPIVGSDKQLCALNHGNMYYSYTVDCAPGLGGSTCGEYVPS Takifugu_rubripes_PRF1.1 SCTQGTPKECLDAE-FAPGSNLAGEGFDITKLERKGAFVIDMNTCTLCSNPYLENKQKLPVSVVDWRSKAS-CTMQITSKLHRSSESLVTSSSSSVDNNWQTNLDNKAASMMLAGTHSKLAEYSMEKTKNDKFSFTSQGMSCTFYSLRVSDSPKLSNEFLRAVRGLPARFYKLIDNFGTHYITKVRLGGSAHSVTSIRQCQASLQGLSTEEVQMCLEAEASSEMKHCKKDTEKMEFKTSFSGLFNDRFTEIKGGQDLLFSAWLNTLPLNPDIVSYSLNSLHELLQVDPARKNLRSAISHYILERGLWKCHNDPAVNQECCPTRKGMARVIITVERGSGLWGDHTTATDGYVKVFFNNMFQRTRVIYNNNDPHWGRVVDLGTQHRVRFEVWDLLGECDRVLSAGDKQDVCALQHGRMFFKWKVECAPSLSGESCTTYKPS Takifugu_rubripes_PRF1.2 ACQTSSFTECQNAP-FVPGHNLVGEGFDVVTMKTSGASVVDVKNCTMCHNSLLNQAQKLPVSVLDWRVKVN-CQRSLSSKIFESSQAVMKETSSSLGVSWKVGLGPKLGGFSVGGSHSKTSAFARSHSRQDKFSFTSYEMKCRYYTFRLHARPPLSKEFEVSLKNLPSAFRQFISVYGTHFIRRVHLGGRVNSMTAIRTCQASISQMSVHTVSNCLSVEAEAASRFCQSKSKSLKTGATFSQAFSDRTTDVLGGDDILFQPWLISLKKVPGLVSYQLSPLHLLVPDNVLQESLRSAISDYISKSAKPLCQGHHMVNSDCCPAEYGVARMNVTVVRAAGLWGDYFSKTDGYVKVFYHQAASATPIIWNNNFPAWNYLIRFETVNPVRFEVWDLLGRDSLVPTSGSISTSFRLKHGSLLVRVSAVCAPSLQGSLCEQYAAS Takifugu_rubripes_PRF1.3 VGYIGTPTECAKAH-FVPGYNLGGEGFDVVTMERKGAFVIDTESCRLYRNRYMNRVQKVPVSVVDWRILPQ-CSLKVDSMLYDSAEALVNDSASSVSNNWKVGLEGASVGVGLGGSHSRESAFGMQKSKQDRYSFSRQSIQCKVYRYRMSKKPLLNAEFLSVVNSLPQQYRALIDTYGTHYITKVALGGSIKAVTSIKTCEAAINGLSTTEVSDCLSVEASAMTEHCKAQKKKLGHSQNYRSMFNERHTEVTGGSDVLFEGWLKSLKTLPDVVQYDLHPLHMVLPAPPAVKGLKAEVEQYIKNNAIATCNSSSHIKSNCCPNGKGLATLKVFRLYAQNLYGDRWSQTDGSVEVTYGNVVKRTNIISNNDNPVWGETFEFGPINKLRFRVYDLLGECSFELHSGKQSNSCMLNHGTFFFSYTAECAPSLGGNRCQEYIPA Takifugu_rubripes_PRF1.5 TCWTASVPECEKAP-FVPGHNLAGKGFDVVRMQRTGAFVINVKTCTLCSNRFQQGTQKLPAAVLDWRPFSR-CSKQLSSALHHSVDSLLRSSSSLVRNNWGIGLSENIGNAVLGGSRSDLAKFARLQHSVDKATFAIHEISCTYYSYRLADHPQLSAEFTKHLKRLPALYRRLIDTYGTHYIHQVQLGGKVRRVTAFKTCLAALKGFTEINVERCLNAELRTLSNKCDNLQRGN-LSMGFYRGFMTHKIEVVGGEDILYQQWINSLHDNPDVVSYAIFPLHQLVQDSQIAANLRDAITGYIQENQLRVCSPTPNLDHHCCPP--GRGTLKVTIHRAVGLNADTSTKADAYVKIFYNGLYDETETVMNNNNPVWNAVFDLGPVLKLKFEVWDFVGKCMTVPERGTHSSGCQLNTGVLYYTYVVGCRG------CDGF--- Takifugu_rubripes_PRF1.6 PCRIGNFSQCQSAP-FVPGHNLVGEGFNVVTLQRKGAYVIDVKTCTLCSNSLQGNLQKLPLSALDWRPFSR-CSADIYGSLHQSVSSLLETYTSQDSSDWKVGLNDKFANLEVGGTQSSAYKYAIRRTGEDRHFFSLHRVTCGYYSYRVSSKPTLSSEFHRDLDRLPAQYNQLIYTYGTHYIRQVYLGGRLRRITASRTCLSTLNALSTSEIHSCLSLGIGNRE-SCKKVLNNQDVSTSFGSGLFQHYTEVVGGTEFSLMSWLNTLKDHPDIVSYSLRPIYELVPSNLTRLGMKAAIEQYLQDNGIKKCSSVPNLASNCCPKEARMGTLDVTIVRAWNLKGDLFGATEAYAKMWFGPFYYRTSMIR-SNNPWWNARYYLSKVFGLKVEVWDRLGSCTWYPQQGTRTVTCPTQGGRGQVRYTLTCDRHLTGSRCERYKPT Tetraodon_nigroviridis_PRF1.1 SCSQGKPQECLEAE-FAPGSNLAGEGFDITKLERKGAFVIDMNTCTLCSNPYLENKQKLPVSVVDWRSQNS-CSLQISSGLHRSSESLLTSSTSSVDNSWGVNLDNKAASMMLAGTQSKLAEYSMEKTKNDKFSFASQSTSCVFYSYRLSSSPTLSQEFRKAVRGLPLKFYRLIDTFGTHYITKVKLGGEVQSVTSIRQCQASLQGLSTEEVQMCLEAEASTELKHCKKDTEKMESKSSFSSLFNDRFTEIKGGQDLLFSSWLNTLPLIPDIISYSLNSLHELLPTSPVRKDLRSAIRHYILEKGLWKCHNNPAVNADCCPTRKGMARVIITVQRATDLWGDHTTATDGYVKVFFNNLVHRSQVIYNNNNPHWAREVDLGTQKKVRLEVWDLLGACQQVLTAGVQQEVCSLQHGRLFYSWKVECAPSLDGPGCTTYKPS Tetraodon_nigroviridis_PRF1.2 ACQTSSFTECQQAP-FVPGHSLVGEGFDVVTMKSSGASVVDVKNCTVCHNPLLNQTQKLPVSVLDWRVKVM-CQRSLSSKIFESSQEVMKEASSSLSVSWKVGLSPLIGGAAVGGSHSRSSQFASSHSRKDKFSFTTHNLKCSYYTFRIHSRPPLSKEFEESLKNLPSAFTQFLSVYGTHFIRRVRLGGHVNSITAIRTCQASMSQMSVQTVSNCLSVEAQAATQFCKTKSSKLKTGATFRQAFSDRSIEVLGGDDVLFNSWLASIKRVPGLVWYQISPLHLLVPDNVLQETLSKAISHYISTRARSLCKGHRLVDANCCPSDYGVARLNVTVVQASGLWGDYFSKTDGYVKVFYGQSSEMTGIIWNNNFPVWNHLIRFQTVKPVTFEVWDLLGRVRVVPTAGSTDRWFRLKHGSVRVRLSAVCAPSLQGSLCEQYAAT Tetraodon_nigroviridis_PRF1.3 TCWTASGPECEKAP-FVPGHNLAGEGFDVVRMRRTGAYVINVKTCTLCPNRFQQGVQKLPAAVLDWRPFSR-CSKQLSSALHHSVDSLLRSSSSLVNNNWGVGLSENIGKVVLGGSRSDLAKFARSQHSVDKATFAIHEISCTYYSYRLADHPQLSAEFTKYLRRLPGPYRRLIDTYGTHYIHQVQLGGKVRRITAFRTCLATLKGFAETDVKTCLNAELRTLSNKCDNLLKGN-MSMGFYQGFMTHKIEVIGGEDILYQQWMNSLHDNPDVISYAIFPLHQLVPDSQIAANLRDAITEYIQENQLRECSPTPNLDHNCCPLRSGRGTLRLMIHRAAGLRADTFTKTDAYVKIFYNGMYEETETVMDDNDPVWNATYNFGSVQELRLEVWDVAGRCVAVPERGTHSFSCQLKKGVLYFTYEAKCDAHLTGFRCGRYSPS ; END; [ The following blocks are output data for analysis step 8694 ] BEGIN TREES; TITLE 'Fish-PRF'; LINK TAXA = TaxaForAnalysisStep8694; TREE Fig._5 = [&R] (Homo_sapiens_PRF1:0.6626942933864676,((Takifugu_rubripes_PRF1.2:0.08258784466321331,Tetraodon_nigroviridis_PRF1.2:0.1488641388216855):0.1969655701555195,(Carassius_auratus_langsdorfii_PRF1.2:0.09260873919857768,Danio_rerio_PRF1.3:0.1166525376346088):0.163784794656962):0.3281091423651014,(((((((Oncorhynchus_mykiss_PRF1:0.00924893192755477,Salmo_salar_PRF1.1:0.01790697469767223):0.1260723154149515,(Paralichthys_olivaceus_PRF1:0.14427142165327,(Takifugu_rubripes_PRF1.1:0.1072008752643791,Tetraodon_nigroviridis_PRF1.1:0.08423101197375922):0.075922983787833,((Oryzias_latipes_PRF1.1:0.03888986842683067,(Oryzias_latipes_PRF1.3:0.03419268701758844,(Oryzias_latipes_PRF1.2:0.01682082865975611,Oryzias_latipes_PRF1.8:0.09055174182300267):0.01601830495819306):0.03998380637428604):0.2983964551802992,Gasterosteus_aculeatus_PRF1.1:0.1713076667228827):0.03917926079364852,Oryzias_latipes_PRF1.4:0.1830388420795712):0.09104855353449495):0.1170067723015182,(Ctenopharyngodon_idella_PRF1.2:0.05014163455663785,Danio_rerio_PRF1.1:0.1376402610337383):0.1712225311784087):0.0828166225528686,((Carassius_auratus_langsdorfii_PRF1.1:0.08229584509066387,Ctenopharyngodon_idella_PRF1.1:0.09663365435355237):0.02819026396526028,Danio_rerio_PRF1.4:0.07189478825122492):0.2831200573164713):0.2204257864954498,Salmo_salar_PRF1.2:0.4198084513896531):0.1057245310955607,((Takifugu_rubripes_PRF1.3:0.1991567994011548,((Gasterosteus_aculeatus_PRF1.2:0.0073874059808071,Gasterosteus_aculeatus_PRF1.6:0.005403773964394711):0.04266988387053104,(Gasterosteus_aculeatus_PRF1.3:0.002516376831958509,Gasterosteus_aculeatus_PRF1.4:0.02690241491432879):0.04399329650684208):0.1967277746268004):0.1565258446989345,(Carassius_auratus_langsdorfii_PRF1.3:0.1566843267519115,((Danio_rerio_PRF1.2:0.02577363090893823,Danio_rerio_PRF1.7:0.01960533000517842):0.1378899386984322,Danio_rerio_PRF1.8:0.109702433998788):0.07266619721656625):0.1277309819534022):0.2360506144945745):0.06199205483712483,((((Takifugu_rubripes_PRF1.5:0.1531266399672572,Tetraodon_nigroviridis_PRF1.3:0.03046146967910467):0.04736926756630954,(Oryzias_latipes_PRF1.6:0.07326707106724631,Gasterosteus_aculeatus_PRF1.5:0.06391485335604496):0.03105727950926421):0.1097032671285356,(Danio_rerio_PRF1.6:0.2164043941250577,Danio_rerio_PRF1.5:0.03440182372558809):0.1134551431256161):0.3315043590768512,(Takifugu_rubripes_PRF1.6:0.1956283436671671,Oryzias_latipes_PRF1.5:0.1994086365512094):0.4210150683695399):0.2876253131535779):0.1128382009614159); [! TreeBASE tree URI: http://purl.org/phylo/treebase/phylows/tree/TB2:Tr51116] END;