@ARTICLE{TreeBASE2Ref24503, author = {Yang Dong and Xiaolei Zhang and Min Xie and Babak Arefnezhad and Zongji Wang and Wenliang Wang and Shaohong Feng and Guodong Huang and Rui Guan and Rowan Bunch and Russell McCulloch and Qiye Li and Bo Li and Guojie Zhang and Xun Xu and James W. Kijas and Ghasem Hosseini Salekdeh and Wen Wang and Yu Jiang}, title = {Reference genome of wild goat (Capra aegagrus) and sequencing of goat breeds provide insight into genic basis of goat domestication.}, year = {2015}, keywords = {wild goat genome, animal domestication, artificial selection, coat color evolution, behavioral evolution.}, doi = {}, url = {http://}, pmid = {}, journal = {BMC Genomics}, volume = {}, number = {}, pages = {}, abstract = {Background Domestic goats (Capra hircus) have been selected to play an essential role in agricultural production systems, since being domesticated from their wild progenitor, bezoar (Capra aegagrus). A detailed understanding of the genetic consequences imparted by the domestication process remains a key goal of evolutionary genomics. Results We constructed the reference genome of bezoar and sequenced representative breeds of domestic goats to search for genomic changes that likely have accompanied goat domestication and breed formation. Thirteen copy number variation genes associated with coat color were identified in domestic goats, among which ASIP gene duplication contributes to the generation of light coat-color phenotype in domestic goats. Analysis of rapidly evolving genes identified genic changes underlying behavior-related traits, immune response and production-related traits. Conclusion Based on the comparison studies of copy number variation genes and rapidly evolving genes between wild and domestic goat, our findings and methodology shed light on the genetic mechanism of animal domestication and will facilitate future goat breeding.} }

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