@ARTICLE{TreeBASE2Ref24078,
author = {Grant D Jones and Ernest P Williams and Allen R Place and Rosemary Jagus and Tsvetan Radoslavov Bachvaroff},
title = {The alveolate translation initiation factor 4E family reveals a custom toolkit for translational control in core dinoflagellates},
year = {2015},
keywords = {Dinoflagellates, translation initiation, eIF4E, phylogeny, alveolate, heterokont},
doi = {},
url = {http://},
pmid = {},
journal = {BMC Evolutionary Biology},
volume = {},
number = {},
pages = {},
abstract = {Background: Dinoflagellates are eukaryotes with unusual cell biology and appear to rely on translational rather than transcriptional control of gene expression. The eukaryotic translation initiation factor 4E (eIF4E) plays an important role in regulating gene expression because eIF4E binding to the mRNA cap is a control point for translation. eIF4E is part of an extended, eukaryote-specific family with different members having specific functions, based on studies of model organisms. Dinoflagellate eIF4E diversity could provide a mechanism for dinoflagellates to regulate gene expression in a post-transcriptional manner. Accordingly, eIF4E family members from eleven core dinoflagellate transcriptomes were surveyed to determine the diversity and phylogeny of the eIF4E family in dinoflagellates and related lineages including apicomplexans, ciliates and heterokonts.
Results: The survey uncovered eight to fifteen (on average eleven) different eIF4E family members in each core dinoflagellates. The eIF4E family members from heterokonts and dinoflagellates segregated into three clades, suggesting at least three eIF4E cognates were present in their common ancestor. However, these three clades are distinct from the three previously described classes of eIF4E, reflecting diverse approaches to a core eukaryotic function. Heterokonts contain four clades, ciliates two and apicomplexans only a single recognizable eIF4E clade. In the core dinoflagellates, the three clades were further divided into nine sub-clades based on the phylogenetic analysis and species representation. Six of the sub-clades contained at least one member from all eleven core dinoflagellate species, suggesting duplication in their shared ancestor. Conservation within sub-clades varied, suggesting different selection pressures.
Conclusions: Phylogenetic analysis of eIF4E in core dinoflagellates revealed complex layering of duplication and conservation when compared to other eukaryotes. Our results suggest that the diverse eIF4E family in core dinoflagellates may provide a toolkit to enable selective translation as a strategy for controlling gene expression in these enigmatic eukaryotes.
}
}
Citation for Study 16938
Citation title:
"The alveolate translation initiation factor 4E family reveals a custom toolkit for translational control in core dinoflagellates".
Study name:
"The alveolate translation initiation factor 4E family reveals a custom toolkit for translational control in core dinoflagellates".
This study is part of submission 16938
(Status: Published).
Citation
Jones G.D., Williams E.P., Place A.R., Jagus R., & Bachvaroff T.R. 2015. The alveolate translation initiation factor 4E family reveals a custom toolkit for translational control in core dinoflagellates. BMC Evolutionary Biology, .
Authors
-
Jones G.D.
-
Williams E.P.
-
Place A.R.
-
Jagus R.
-
Bachvaroff T.R.
(submitter)
301 367 0559
Abstract
Background: Dinoflagellates are eukaryotes with unusual cell biology and appear to rely on translational rather than transcriptional control of gene expression. The eukaryotic translation initiation factor 4E (eIF4E) plays an important role in regulating gene expression because eIF4E binding to the mRNA cap is a control point for translation. eIF4E is part of an extended, eukaryote-specific family with different members having specific functions, based on studies of model organisms. Dinoflagellate eIF4E diversity could provide a mechanism for dinoflagellates to regulate gene expression in a post-transcriptional manner. Accordingly, eIF4E family members from eleven core dinoflagellate transcriptomes were surveyed to determine the diversity and phylogeny of the eIF4E family in dinoflagellates and related lineages including apicomplexans, ciliates and heterokonts.
Results: The survey uncovered eight to fifteen (on average eleven) different eIF4E family members in each core dinoflagellates. The eIF4E family members from heterokonts and dinoflagellates segregated into three clades, suggesting at least three eIF4E cognates were present in their common ancestor. However, these three clades are distinct from the three previously described classes of eIF4E, reflecting diverse approaches to a core eukaryotic function. Heterokonts contain four clades, ciliates two and apicomplexans only a single recognizable eIF4E clade. In the core dinoflagellates, the three clades were further divided into nine sub-clades based on the phylogenetic analysis and species representation. Six of the sub-clades contained at least one member from all eleven core dinoflagellate species, suggesting duplication in their shared ancestor. Conservation within sub-clades varied, suggesting different selection pressures.
Conclusions: Phylogenetic analysis of eIF4E in core dinoflagellates revealed complex layering of duplication and conservation when compared to other eukaryotes. Our results suggest that the diverse eIF4E family in core dinoflagellates may provide a toolkit to enable selective translation as a strategy for controlling gene expression in these enigmatic eukaryotes.
Keywords
Dinoflagellates, translation initiation, eIF4E, phylogeny, alveolate, heterokont
External links
About this resource
- Canonical resource URI:
http://purl.org/phylo/treebase/phylows/study/TB2:S16938
- Other versions:
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- Show BibTeX reference
@ARTICLE{TreeBASE2Ref24078,
author = {Grant D Jones and Ernest P Williams and Allen R Place and Rosemary Jagus and Tsvetan Radoslavov Bachvaroff},
title = {The alveolate translation initiation factor 4E family reveals a custom toolkit for translational control in core dinoflagellates},
year = {2015},
keywords = {Dinoflagellates, translation initiation, eIF4E, phylogeny, alveolate, heterokont},
doi = {},
url = {http://},
pmid = {},
journal = {BMC Evolutionary Biology},
volume = {},
number = {},
pages = {},
abstract = {Background: Dinoflagellates are eukaryotes with unusual cell biology and appear to rely on translational rather than transcriptional control of gene expression. The eukaryotic translation initiation factor 4E (eIF4E) plays an important role in regulating gene expression because eIF4E binding to the mRNA cap is a control point for translation. eIF4E is part of an extended, eukaryote-specific family with different members having specific functions, based on studies of model organisms. Dinoflagellate eIF4E diversity could provide a mechanism for dinoflagellates to regulate gene expression in a post-transcriptional manner. Accordingly, eIF4E family members from eleven core dinoflagellate transcriptomes were surveyed to determine the diversity and phylogeny of the eIF4E family in dinoflagellates and related lineages including apicomplexans, ciliates and heterokonts.
Results: The survey uncovered eight to fifteen (on average eleven) different eIF4E family members in each core dinoflagellates. The eIF4E family members from heterokonts and dinoflagellates segregated into three clades, suggesting at least three eIF4E cognates were present in their common ancestor. However, these three clades are distinct from the three previously described classes of eIF4E, reflecting diverse approaches to a core eukaryotic function. Heterokonts contain four clades, ciliates two and apicomplexans only a single recognizable eIF4E clade. In the core dinoflagellates, the three clades were further divided into nine sub-clades based on the phylogenetic analysis and species representation. Six of the sub-clades contained at least one member from all eleven core dinoflagellate species, suggesting duplication in their shared ancestor. Conservation within sub-clades varied, suggesting different selection pressures.
Conclusions: Phylogenetic analysis of eIF4E in core dinoflagellates revealed complex layering of duplication and conservation when compared to other eukaryotes. Our results suggest that the diverse eIF4E family in core dinoflagellates may provide a toolkit to enable selective translation as a strategy for controlling gene expression in these enigmatic eukaryotes.
}
}
- Show RIS reference
TY - JOUR
ID - 24078
AU - Jones,Grant D
AU - Williams,Ernest P
AU - Place,Allen R
AU - Jagus,Rosemary
AU - Bachvaroff,Tsvetan Radoslavov
T1 - The alveolate translation initiation factor 4E family reveals a custom toolkit for translational control in core dinoflagellates
PY - 2015
KW - Dinoflagellates
KW - translation initiation
KW - eIF4E
KW - phylogeny
KW - alveolate
KW - heterokont
UR - http://dx.doi.org/
N2 - Background: Dinoflagellates are eukaryotes with unusual cell biology and appear to rely on translational rather than transcriptional control of gene expression. The eukaryotic translation initiation factor 4E (eIF4E) plays an important role in regulating gene expression because eIF4E binding to the mRNA cap is a control point for translation. eIF4E is part of an extended, eukaryote-specific family with different members having specific functions, based on studies of model organisms. Dinoflagellate eIF4E diversity could provide a mechanism for dinoflagellates to regulate gene expression in a post-transcriptional manner. Accordingly, eIF4E family members from eleven core dinoflagellate transcriptomes were surveyed to determine the diversity and phylogeny of the eIF4E family in dinoflagellates and related lineages including apicomplexans, ciliates and heterokonts.
Results: The survey uncovered eight to fifteen (on average eleven) different eIF4E family members in each core dinoflagellates. The eIF4E family members from heterokonts and dinoflagellates segregated into three clades, suggesting at least three eIF4E cognates were present in their common ancestor. However, these three clades are distinct from the three previously described classes of eIF4E, reflecting diverse approaches to a core eukaryotic function. Heterokonts contain four clades, ciliates two and apicomplexans only a single recognizable eIF4E clade. In the core dinoflagellates, the three clades were further divided into nine sub-clades based on the phylogenetic analysis and species representation. Six of the sub-clades contained at least one member from all eleven core dinoflagellate species, suggesting duplication in their shared ancestor. Conservation within sub-clades varied, suggesting different selection pressures.
Conclusions: Phylogenetic analysis of eIF4E in core dinoflagellates revealed complex layering of duplication and conservation when compared to other eukaryotes. Our results suggest that the diverse eIF4E family in core dinoflagellates may provide a toolkit to enable selective translation as a strategy for controlling gene expression in these enigmatic eukaryotes.
L3 -
JF - BMC Evolutionary Biology
VL -
IS -
ER -