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Citation for Study 1063

Citation title: "Phylogeography of the Fungal Pathogen Histoplasma capsulatum.".

This study was previously identified under the legacy study ID S960 (Status: Published).

Citation

Kasuga T., White T., Koenig G., Mcewen J., Restrepo A., Castaneda E., Lacaz C., Heins-vaccari E., De freitas R., Zancope-oliveira R., Qin Z., Negroni R., Carter D., Mikami Y., Tamura M., Taylor M., Miller G., Poonwan N., & Taylor J. 2003. Phylogeography of the Fungal Pathogen Histoplasma capsulatum. Molecular Ecology, null.

Authors

• Kasuga T.
• White T.
• Koenig G.
• Mcewen J.
• Restrepo A.
• Castaneda E.
• Lacaz C.
• Heins-vaccari E.
• De freitas R.
• Zancope-oliveira R.
• Qin Z.
• Negroni R.
• Carter D.
• Mikami Y.
• Tamura M.
• Taylor M.
• Miller G.
• Poonwan N.
• Taylor J.

Abstract

Until recently, Histoplasma capsulatum was believed to harbor three varieties; var. capsulatum (chiefly a New World human pathogen), var. duboisii (an African human pathogen) and var. farciminosum (an Old World horse pathogen), which varied in clinical manifestations and geographical distribution. We analyzed the phylogenetic relationships of 137 individuals representing the three varieties from six continents using DNA sequence variation in four independent protein-coding genes. At least eight clades were identified: (1) North American class 1 clade, (2) North American class 2 clade, (3) Latin American group A clade, (4) Latin American group B clade, (5) Australian clade, (6) Netherlands (Indonesian?) clade, (7) Eurasian clade, and (8) African clade. Seven of eight clades represented genetically isolated groups that may be recognized as phylogenetic species. The sole exception was the Eurasian clade, which originated from within the Latin American group A clade. The phylogenetic relationships among the clades made a star phylogeny. H. capsulatum var. capsulatum individuals were found in all eight clades. The African clade included all of the H. capsulatum var. duboisii individuals, as well as individuals of the other two varieties. The thirteen individuals of var. farciminosum were distributed among three phylogenetic species. These findings suggest that the three varieties of Histoplasma are phylogenetically meaningless. Instead we have to recognize the existence of genetically distinct geographical populations or phylogenetic species. Combining DNA substitution rates of protein-coding genes with the phylogeny suggests that the radiation of Histoplasma started between three and thirteen million years ago in Latin America.

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S1063
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref16064,
  	 author = {Takao  Kasuga and Tom J  White and Gina L  Koenig and Juan  McEwen and Angela  Restrepo and Elizabetha  Castaneda and Carlos da Silva  Lacaz and Elisabeth M  Heins-Vaccari and Roseli S  de Freitas and Rosely M  Zancope-Oliveira and Zhenyu  Qin and Ricardo  Negroni and Dee A.  Carter and Yuzuru  Mikami and Miki  Tamura and Maria Lucia  Taylor and Georgina F  Miller and Natteewan  Poonwan and John W.  Taylor},
  	 title = {Phylogeography of the Fungal Pathogen Histoplasma capsulatum.},
  	 year = {2003},
  	 keywords = {},
  	 doi = {},
  	 url = {},
  	 pmid = {},
  	 journal = {Molecular Ecology},
  	 volume = {},
  	 number = {},
  	 pages = {},
  	 abstract = {Until recently, Histoplasma capsulatum was believed to harbor three varieties; var. capsulatum (chiefly a New World human pathogen), var. duboisii (an African human pathogen) and var. farciminosum (an Old World horse pathogen), which varied in clinical manifestations and geographical distribution. We analyzed the phylogenetic relationships of 137 individuals representing the three varieties from six continents using DNA sequence variation in four independent protein-coding genes. At least eight clades were identified: (1) North American class 1 clade, (2) North American class 2 clade, (3) Latin American group A clade, (4) Latin American group B clade, (5) Australian clade, (6) Netherlands (Indonesian?) clade, (7) Eurasian clade, and (8) African clade. Seven of eight clades represented genetically isolated groups that may be recognized as phylogenetic species. The sole exception was the Eurasian clade, which originated from within the Latin American group A clade. The phylogenetic relationships among the clades made a star phylogeny. H. capsulatum var. capsulatum individuals were found in all eight clades. The African clade included all of the H. capsulatum var. duboisii individuals, as well as individuals of the other two varieties. The thirteen individuals of var. farciminosum were distributed among three phylogenetic species. These findings suggest that the three varieties of Histoplasma are phylogenetically meaningless. Instead we have to recognize the existence of genetically distinct geographical populations or phylogenetic species. Combining DNA substitution rates of protein-coding genes with the phylogeny suggests that the radiation of Histoplasma started between three and thirteen million years ago in Latin America.}
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 16064
  AU  - Kasuga,Takao 
  AU  - White,Tom J 
  AU  - Koenig,Gina L 
  AU  - McEwen,Juan 
  AU  - Restrepo,Angela 
  AU  - Castaneda,Elizabetha 
  AU  - Lacaz,Carlos da Silva 
  AU  - Heins-Vaccari,Elisabeth M 
  AU  - de Freitas,Roseli S 
  AU  - Zancope-Oliveira,Rosely M 
  AU  - Qin,Zhenyu 
  AU  - Negroni,Ricardo 
  AU  - Carter,Dee A. 
  AU  - Mikami,Yuzuru 
  AU  - Tamura,Miki 
  AU  - Taylor,Maria Lucia 
  AU  - Miller,Georgina F 
  AU  - Poonwan,Natteewan 
  AU  - Taylor,John W. 
  T1  - Phylogeography of the Fungal Pathogen Histoplasma capsulatum.
  PY  - 2003
  KW  - 
  UR  - 
  N2  - Until recently, Histoplasma capsulatum was believed to harbor three varieties; var. capsulatum (chiefly a New World human pathogen), var. duboisii (an African human pathogen) and var. farciminosum (an Old World horse pathogen), which varied in clinical manifestations and geographical distribution. We analyzed the phylogenetic relationships of 137 individuals representing the three varieties from six continents using DNA sequence variation in four independent protein-coding genes. At least eight clades were identified: (1) North American class 1 clade, (2) North American class 2 clade, (3) Latin American group A clade, (4) Latin American group B clade, (5) Australian clade, (6) Netherlands (Indonesian?) clade, (7) Eurasian clade, and (8) African clade. Seven of eight clades represented genetically isolated groups that may be recognized as phylogenetic species. The sole exception was the Eurasian clade, which originated from within the Latin American group A clade. The phylogenetic relationships among the clades made a star phylogeny. H. capsulatum var. capsulatum individuals were found in all eight clades. The African clade included all of the H. capsulatum var. duboisii individuals, as well as individuals of the other two varieties. The thirteen individuals of var. farciminosum were distributed among three phylogenetic species. These findings suggest that the three varieties of Histoplasma are phylogenetically meaningless. Instead we have to recognize the existence of genetically distinct geographical populations or phylogenetic species. Combining DNA substitution rates of protein-coding genes with the phylogeny suggests that the radiation of Histoplasma started between three and thirteen million years ago in Latin America.
  L3  - 
  JF  - Molecular Ecology
  VL  - 
  IS  - 
  ER  -