CiteULike

Delicious

Connotea

Citation for Study 24158

Citation title: "From root to tips: sporulation evolution and specialization in Bacillus subtilis and the intestinal pathogen Clostridioides difficile".

Study name: "From root to tips: sporulation evolution and specialization in Bacillus subtilis and the intestinal pathogen Clostridioides difficile".

This study is part of submission 24158 (Status: Published).

Citation

Ramos-silva P., Serrano M., & Henriques A.O. 2019. From root to tips: sporulation evolution and specialization in Bacillus subtilis and the intestinal pathogen Clostridioides difficile. Molecular Biology and Evolution, .

Authors

• Ramos-silva P. (submitter) +3171751 9283
• Serrano M.
• Henriques A.O.

Abstract

Bacteria of the Firmicutes phylum are able to enter a developmental pathway that culminates with the formation of a highly resistant, dormant spore. Spores allow environmental persistence, dissemination and for pathogens, are infection vehicles. In both the model Bacillus subtilis, an aerobic species, and in the intestinal pathogen Clostridioides difficile, an obligate anaerobe, sporulation mobilizes hundreds of genes. Their expression is coordinated between the forespore and the mother cell, the two cells that participate in the process, and is kept in close register with the course of morphogenesis. The evolutionary mechanisms by which sporulation emerged and evolved in these two species, and more broadly across Firmicutes, remain largely unknown. Here, we trace the origin and evolution of sporulation. Using the genes involved in the process in B. subtilis and C. difficile, and estimating their gain-loss dynamics in a comprehensive bacterial macro-evolutionary framework we show that sporulation evolution was driven by two major gene gain events, the first at the base of the Firmicutes and the second at the base of the B. subtilis group and within the Peptostreptococcaceae family, which includes C. difficile. We also show that early and late sporulation regulons have been co-evolving and that sporulation genes entail greater innovation in B. subtilis with many Bacilli-lineage restricted genes. In contrast, C. difficile more often recruits new sporulation genes by horizontal gene transfer, which reflects both its highly mobile genome, the complexity of the gut microbiota and an adjustment of sporulation to this particular ecosystem.

Keywords

sporulation, bacterial genome evolution, horizontal gene transfer, taxon-specific genes, Bacillus subtilis, Clostridioides difficile

External links

• DOI: 10.1093/molbev/msz175

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S24158
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref29411,
  	 author = {Paula  Ramos-Silva and M?nica  Serrano and Adriano O. Henriques},
  	 title = {From root to tips: sporulation evolution and specialization in Bacillus subtilis and the intestinal pathogen Clostridioides difficile},
  	 year = {2019},
  	 keywords = {sporulation, bacterial genome evolution, horizontal gene transfer, taxon-specific genes, Bacillus subtilis, Clostridioides difficile},
  	 doi = {10.1093/molbev/msz175},
  	 url = {http://},
  	 pmid = {},
  	 journal = {Molecular Biology and Evolution},
  	 volume = {},
  	 number = {},
  	 pages = {},
  	 abstract = {Bacteria of the Firmicutes phylum are able to enter a developmental pathway that culminates with the formation of a highly resistant, dormant spore. Spores allow environmental persistence, dissemination and for pathogens, are infection vehicles. In both the model Bacillus subtilis, an aerobic species, and in the intestinal pathogen Clostridioides difficile, an obligate anaerobe, sporulation mobilizes hundreds of genes. Their expression is coordinated between the forespore and the mother cell, the two cells that participate in the process, and is kept in close register with the course of morphogenesis. The evolutionary mechanisms by which sporulation emerged and evolved in these two species, and more broadly across Firmicutes, remain largely unknown. Here, we trace the origin and evolution of sporulation. Using the genes involved in the process in B. subtilis and C. difficile, and estimating their gain-loss dynamics in a comprehensive bacterial macro-evolutionary framework we show that sporulation evolution was driven by two major gene gain events, the first at the base of the Firmicutes and the second at the base of the B. subtilis group and within the Peptostreptococcaceae family, which includes C. difficile. We also show that early and late sporulation regulons have been co-evolving and that sporulation genes entail greater innovation in B. subtilis with many Bacilli-lineage restricted genes. In contrast, C. difficile more often recruits new sporulation genes by horizontal gene transfer, which reflects both its highly mobile genome, the complexity of the gut microbiota and an adjustment of sporulation to this particular ecosystem. }
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 29411
  AU  - Ramos-Silva,Paula 
  AU  - Serrano,M?nica 
  AU  - Henriques,Adriano O.
  T1  - From root to tips: sporulation evolution and specialization in Bacillus subtilis and the intestinal pathogen Clostridioides difficile
  PY  - 2019
  KW  - sporulation
  KW  - bacterial genome evolution
  KW  - horizontal gene transfer
  KW  - taxon-specific genes
  KW  - Bacillus subtilis
  KW  - Clostridioides difficile
  UR  - http://dx.doi.org/10.1093/molbev/msz175
  N2  - Bacteria of the Firmicutes phylum are able to enter a developmental pathway that culminates with the formation of a highly resistant, dormant spore. Spores allow environmental persistence, dissemination and for pathogens, are infection vehicles. In both the model Bacillus subtilis, an aerobic species, and in the intestinal pathogen Clostridioides difficile, an obligate anaerobe, sporulation mobilizes hundreds of genes. Their expression is coordinated between the forespore and the mother cell, the two cells that participate in the process, and is kept in close register with the course of morphogenesis. The evolutionary mechanisms by which sporulation emerged and evolved in these two species, and more broadly across Firmicutes, remain largely unknown. Here, we trace the origin and evolution of sporulation. Using the genes involved in the process in B. subtilis and C. difficile, and estimating their gain-loss dynamics in a comprehensive bacterial macro-evolutionary framework we show that sporulation evolution was driven by two major gene gain events, the first at the base of the Firmicutes and the second at the base of the B. subtilis group and within the Peptostreptococcaceae family, which includes C. difficile. We also show that early and late sporulation regulons have been co-evolving and that sporulation genes entail greater innovation in B. subtilis with many Bacilli-lineage restricted genes. In contrast, C. difficile more often recruits new sporulation genes by horizontal gene transfer, which reflects both its highly mobile genome, the complexity of the gut microbiota and an adjustment of sporulation to this particular ecosystem. 
  L3  - 10.1093/molbev/msz175
  JF  - Molecular Biology and Evolution
  VL  - 
  IS  - 
  ER  -