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Citation for Study 13758

Citation title: "Characterization of Hairless (Hr) and FGF5 Genes Provides Insights into Molecular Basis of Hair Loss in Cetaceans".

Study name: "Characterization of Hairless (Hr) and FGF5 Genes Provides Insights into Molecular Basis of Hair Loss in Cetaceans".

This study is part of submission 13758 (Status: Published).

Citation

Chen Z. 2013. Characterization of Hairless (Hr) and FGF5 Genes Provides Insights into Molecular Basis of Hair Loss in Cetaceans. BMC Evolutionary Biology, 13(34).

Authors

• Chen Z. (submitter)

Abstract

Background: Hair is one of the main distinguishing characteristics of mammals and it has many important biological functions. Cetaceans originated from terrestrial mammals and they have evolved a series of adaptations to aquatic environments, which are of evolutionary significance. However, the molecular mechanisms underlying their aquatic adaptations have not been well explored. This study provided insights into the evolution of hair loss during the transition from land to water by investigating and comparing two essential regulators of hair follicle development and hair follicle cycling, i.e., the Hairless (Hr) and FGF5 genes, in representative cetaceans and their terrestrial relatives. Results: The full open reading frame sequences of the Hr and FGF5 genes were characterized in seven cetaceans. The sequence characteristics and evolutionary analyses suggested the functional loss of the Hr gene in cetaceans, which supports the loss of hair during their full adaptation to aquatic habitats. By contrast, positive selection for the FGF5 gene was found in cetaceans where a series of positively selected amino acid residues were identified. Conclusions: This is the first study to investigate the molecular basis of the hair loss in cetaceans. Our investigation of Hr and FGF5, two indispensable regulators of the hair cycle, provide some new insights into the molecular basis of hair loss in cetaceans. The results suggest that positive selection for the FGF5 gene might have promoted the termination of hair growth and early entry into the catagen stage of hair follicle cycling. Consequently, the hair follicle cycle was disrupted and the hair was lost completely due to the loss of the Hr gene function in cetaceans. This suggests that cetaceans have evolved an effective and complex mechanism for hair loss.

External links

• DOI: 10.1186/1471-2148-13-34
• Other URL: http://www.biomedcentral.com/1471-2148/13/34

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S13758
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref21635,
  	 author = {Zhuo  Chen},
  	 title = {Characterization of Hairless (Hr) and FGF5 Genes Provides Insights into Molecular Basis of Hair Loss in Cetaceans},
  	 year = {2013},
  	 keywords = {},
  	 doi = {10.1186/1471-2148-13-34},
  	 url = {http://www.biomedcentral.com/1471-2148/13/34},
  	 pmid = {},
  	 journal = {BMC Evolutionary Biology},
  	 volume = {13},
  	 number = {34},
  	 pages = {},
  	 abstract = {Background:
  Hair is one of the main distinguishing characteristics of mammals and it has many important biological functions. Cetaceans originated from terrestrial mammals and they have evolved a series of adaptations to aquatic environments, which are of evolutionary significance. However, the molecular mechanisms underlying their aquatic adaptations have not been well explored. This study provided insights into the evolution of hair loss during the transition from land to water by investigating and comparing two essential regulators of hair follicle development and hair follicle cycling, i.e., the Hairless (Hr) and FGF5 genes, in representative cetaceans and their terrestrial relatives.
  Results:
  The full open reading frame sequences of the Hr and FGF5 genes were characterized in seven cetaceans. The sequence characteristics and evolutionary analyses suggested the functional loss of the Hr gene in cetaceans, which supports the loss of hair during their full adaptation to aquatic habitats. By contrast, positive selection for the FGF5 gene was found in cetaceans where a series of positively selected amino acid residues were identified.
  Conclusions:
  This is the first study to investigate the molecular basis of the hair loss in cetaceans. Our investigation of Hr and FGF5, two indispensable regulators of the hair cycle, provide some new insights into the molecular basis of hair loss in cetaceans. The results suggest that positive selection for the FGF5 gene might have promoted the termination of hair growth and early entry into the catagen stage of hair follicle cycling. Consequently, the hair follicle cycle was disrupted and the hair was lost completely due to the loss of the Hr gene function in cetaceans. This suggests that cetaceans have evolved an effective and complex mechanism for hair loss.
  }
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 21635
  AU  - Chen,Zhuo 
  T1  - Characterization of Hairless (Hr) and FGF5 Genes Provides Insights into Molecular Basis of Hair Loss in Cetaceans
  PY  - 2013
  KW  - 
  UR  - http://www.biomedcentral.com/1471-2148/13/34
  N2  - Background:
  Hair is one of the main distinguishing characteristics of mammals and it has many important biological functions. Cetaceans originated from terrestrial mammals and they have evolved a series of adaptations to aquatic environments, which are of evolutionary significance. However, the molecular mechanisms underlying their aquatic adaptations have not been well explored. This study provided insights into the evolution of hair loss during the transition from land to water by investigating and comparing two essential regulators of hair follicle development and hair follicle cycling, i.e., the Hairless (Hr) and FGF5 genes, in representative cetaceans and their terrestrial relatives.
  Results:
  The full open reading frame sequences of the Hr and FGF5 genes were characterized in seven cetaceans. The sequence characteristics and evolutionary analyses suggested the functional loss of the Hr gene in cetaceans, which supports the loss of hair during their full adaptation to aquatic habitats. By contrast, positive selection for the FGF5 gene was found in cetaceans where a series of positively selected amino acid residues were identified.
  Conclusions:
  This is the first study to investigate the molecular basis of the hair loss in cetaceans. Our investigation of Hr and FGF5, two indispensable regulators of the hair cycle, provide some new insights into the molecular basis of hair loss in cetaceans. The results suggest that positive selection for the FGF5 gene might have promoted the termination of hair growth and early entry into the catagen stage of hair follicle cycling. Consequently, the hair follicle cycle was disrupted and the hair was lost completely due to the loss of the Hr gene function in cetaceans. This suggests that cetaceans have evolved an effective and complex mechanism for hair loss.
  
  L3  - 10.1186/1471-2148-13-34
  JF  - BMC Evolutionary Biology
  VL  - 13
  IS  - 34
  ER  -