@ARTICLE{TreeBASE2Ref24399,
author = {Vanessa Weber de Melo and Hanan Sheikh Ali and Jona Freise and Denise K?hnert and Sandra Essbauer and Marc Mertens and Konrad M. Wanka and Stephan Drewes and Rainer G. Ulrich and Gerald Heckel},
title = {Spatiotemporal dynamics of Puumala hantavirus associated with its rodent host, Myodes glareolus},
year = {2015},
keywords = {zoonosis; population dynamics; genetic structure; host-parasite evolution; rodent-borne disease; Nephropathia epidemica, vole},
doi = {},
url = {http://},
pmid = {},
journal = {Evolutionary Applications},
volume = {},
number = {},
pages = {},
abstract = {Many viruses significantly impact human and animal health. Understanding the population dynamics of these viruses and their hosts can provide important insights for epidemiology and virus evolution. Puumala virus (PUUV) is a European hantavirus that may cause regional outbreaks of hemorrhagic fever with renal syndrome in humans. Here, we analyzed the spatiotemporal dynamics of PUUV circulating in local populations of its rodent reservoir host, the bank vole (Myodes glareolus) during eight years. Phylogenetic and population genetic analyses of all three genome segments of PUUV showed strong geographical structuring at a very local scale. There was a high temporal turnover of virus strains in the local bank vole populations but several virus strains persisted through multiple years. Phylodynamic analyses showed no significant changes in the local effective population sizes of PUUV, although vole numbers and virus prevalence fluctuated widely. Microsatellite data demonstrated also a temporally persisting subdivision between local vole populations, but these groups did not correspond to the subdivision in the virus strains. We conclude that restricted transmission between vole populations and genetic drift play important roles in shaping the genetic structure and temporal dynamics of PUUV in its natural host which has several implications for zoonotic risks of the human population.}
}
Citation for Study 17360
Citation title:
"Spatiotemporal dynamics of Puumala hantavirus associated with its rodent host, Myodes glareolus".
Study name:
"Spatiotemporal dynamics of Puumala hantavirus associated with its rodent host, Myodes glareolus".
This study is part of submission 17360
(Status: Published).
Citation
Weber de melo V., Sheikh ali H., Freise J., K?hnert D., Essbauer S., Mertens M., Wanka K.M., Drewes S., Ulrich R.G., & Heckel G. 2015. Spatiotemporal dynamics of Puumala hantavirus associated with its rodent host, Myodes glareolus. Evolutionary Applications, .
Authors
-
Weber de melo V.
-
Sheikh ali H.
-
Freise J.
-
K?hnert D.
-
Essbauer S.
-
Mertens M.
-
Wanka K.M.
-
Drewes S.
-
Ulrich R.G.
-
Heckel G.
Abstract
Many viruses significantly impact human and animal health. Understanding the population dynamics of these viruses and their hosts can provide important insights for epidemiology and virus evolution. Puumala virus (PUUV) is a European hantavirus that may cause regional outbreaks of hemorrhagic fever with renal syndrome in humans. Here, we analyzed the spatiotemporal dynamics of PUUV circulating in local populations of its rodent reservoir host, the bank vole (Myodes glareolus) during eight years. Phylogenetic and population genetic analyses of all three genome segments of PUUV showed strong geographical structuring at a very local scale. There was a high temporal turnover of virus strains in the local bank vole populations but several virus strains persisted through multiple years. Phylodynamic analyses showed no significant changes in the local effective population sizes of PUUV, although vole numbers and virus prevalence fluctuated widely. Microsatellite data demonstrated also a temporally persisting subdivision between local vole populations, but these groups did not correspond to the subdivision in the virus strains. We conclude that restricted transmission between vole populations and genetic drift play important roles in shaping the genetic structure and temporal dynamics of PUUV in its natural host which has several implications for zoonotic risks of the human population.
Keywords
zoonosis; population dynamics; genetic structure; host-parasite evolution; rodent-borne disease; Nephropathia epidemica, vole
External links
About this resource
- Canonical resource URI:
http://purl.org/phylo/treebase/phylows/study/TB2:S17360
- Other versions:
Nexus
NeXML
- Show BibTeX reference
@ARTICLE{TreeBASE2Ref24399,
author = {Vanessa Weber de Melo and Hanan Sheikh Ali and Jona Freise and Denise K?hnert and Sandra Essbauer and Marc Mertens and Konrad M. Wanka and Stephan Drewes and Rainer G. Ulrich and Gerald Heckel},
title = {Spatiotemporal dynamics of Puumala hantavirus associated with its rodent host, Myodes glareolus},
year = {2015},
keywords = {zoonosis; population dynamics; genetic structure; host-parasite evolution; rodent-borne disease; Nephropathia epidemica, vole},
doi = {},
url = {http://},
pmid = {},
journal = {Evolutionary Applications},
volume = {},
number = {},
pages = {},
abstract = {Many viruses significantly impact human and animal health. Understanding the population dynamics of these viruses and their hosts can provide important insights for epidemiology and virus evolution. Puumala virus (PUUV) is a European hantavirus that may cause regional outbreaks of hemorrhagic fever with renal syndrome in humans. Here, we analyzed the spatiotemporal dynamics of PUUV circulating in local populations of its rodent reservoir host, the bank vole (Myodes glareolus) during eight years. Phylogenetic and population genetic analyses of all three genome segments of PUUV showed strong geographical structuring at a very local scale. There was a high temporal turnover of virus strains in the local bank vole populations but several virus strains persisted through multiple years. Phylodynamic analyses showed no significant changes in the local effective population sizes of PUUV, although vole numbers and virus prevalence fluctuated widely. Microsatellite data demonstrated also a temporally persisting subdivision between local vole populations, but these groups did not correspond to the subdivision in the virus strains. We conclude that restricted transmission between vole populations and genetic drift play important roles in shaping the genetic structure and temporal dynamics of PUUV in its natural host which has several implications for zoonotic risks of the human population.}
}
- Show RIS reference
TY - JOUR
ID - 24399
AU - Weber de Melo,Vanessa
AU - Sheikh Ali,Hanan
AU - Freise,Jona
AU - K?hnert,Denise
AU - Essbauer,Sandra
AU - Mertens,Marc
AU - Wanka,Konrad M.
AU - Drewes,Stephan
AU - Ulrich,Rainer G.
AU - Heckel,Gerald
T1 - Spatiotemporal dynamics of Puumala hantavirus associated with its rodent host, Myodes glareolus
PY - 2015
KW - zoonosis; population dynamics; genetic structure; host-parasite evolution; rodent-borne disease; Nephropathia epidemica
KW - vole
UR - http://dx.doi.org/
N2 - Many viruses significantly impact human and animal health. Understanding the population dynamics of these viruses and their hosts can provide important insights for epidemiology and virus evolution. Puumala virus (PUUV) is a European hantavirus that may cause regional outbreaks of hemorrhagic fever with renal syndrome in humans. Here, we analyzed the spatiotemporal dynamics of PUUV circulating in local populations of its rodent reservoir host, the bank vole (Myodes glareolus) during eight years. Phylogenetic and population genetic analyses of all three genome segments of PUUV showed strong geographical structuring at a very local scale. There was a high temporal turnover of virus strains in the local bank vole populations but several virus strains persisted through multiple years. Phylodynamic analyses showed no significant changes in the local effective population sizes of PUUV, although vole numbers and virus prevalence fluctuated widely. Microsatellite data demonstrated also a temporally persisting subdivision between local vole populations, but these groups did not correspond to the subdivision in the virus strains. We conclude that restricted transmission between vole populations and genetic drift play important roles in shaping the genetic structure and temporal dynamics of PUUV in its natural host which has several implications for zoonotic risks of the human population.
L3 -
JF - Evolutionary Applications
VL -
IS -
ER -