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Citation for Study 12087

Citation title: "Is Permanent Parasitism Reversible??Critical Evidence from Early Evolution of House Dust Mites.".

Study name: "Is Permanent Parasitism Reversible??Critical Evidence from Early Evolution of House Dust Mites.".

This study is part of submission 12087 (Status: Published).

Citation

Klimov P.B., & Oconnor B. 2011. Is Permanent Parasitism Reversible??Critical Evidence from Early Evolution of House Dust Mites. Systematic Biology, 62(3): 411-423.

Authors

• Klimov P.B. (submitter) (734)763-4354
• Oconnor B.

Abstract

Long-term specialization may limit the ability of a species to respond to new environmental conditions and lead to a higher likelihood of extinction. For permanent parasites and other symbionts, the most intriguing question is whether these organisms can return to a free-living lifestyle and, thus, escape an evolutionary ?dead end.? This question is directly related to Dollo?s law, which stipulates that a complex trait (such as being free living vs. parasitic) cannot re-evolve again in the same form. Here, we present conclusive evidence that house dust mites, a group of medically important free-living organisms, evolved from permanent parasites of warm-blooded vertebrates. A robust, multigene topology (315 taxa, 8942 nt), ancestral character state reconstruction, and a test for irreversible evolution (Dollo?s law) demonstrate that house dust mites have abandoned a parasitic lifestyle, secondarily becoming free living, and then speciated in several habitats. Hence, as exemplified by this model system, highly specialized permanent parasites may drastically de-specialize to the extent of becoming free living and, thus escape from dead-end evolution. Our phylogenetic and historical ecological framework explains the limited cross-reactivity between allergens from the house dust mites and ?storage? mites and the ability of the dust mites to inhibit host immune responses. It also provides insights into how ancestral features related to parasitism (frequent ancestral shifts to unrelated hosts, tolerance to lower humidity, and pre-existing enzymes targeting skin and keratinous materials) played a major role in reversal to the free-living state. We propose that parasitic ancestors of pyroglyphids shifted to nests of vertebrates. Later the nest-inhabiting pyroglyphids expanded into human dwellings to become a major source of allergens.

Keywords

Ancestral ecology; Dollo?s law; evolutionary ?dead end?; house dust mites; permanent parasitism; Pyroglyphidae.

External links

• DOI: 10.1093/sysbio/syt008

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S12087
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref20190,
  	 author = {Pavel B Klimov and Barry M  OConnor},
  	 title = {Is Permanent Parasitism Reversible??Critical Evidence from Early Evolution of House Dust Mites.},
  	 year = {2011},
  	 keywords = {Ancestral ecology; Dollo?s law; evolutionary ?dead end?; house dust mites; permanent parasitism; Pyroglyphidae.},
  	 doi = {10.1093/sysbio/syt008},
  	 url = {http://},
  	 pmid = {},
  	 journal = {Systematic Biology},
  	 volume = {62},
  	 number = {3},
  	 pages = {411--423},
  	 abstract = {Long-term specialization may limit the ability of a species to respond to new environmental conditions and lead to a higher likelihood of extinction. For permanent parasites and other symbionts, the most intriguing question is whether these organisms can return to a free-living lifestyle and, thus, escape an evolutionary ?dead end.? This question is directly related to Dollo?s law, which stipulates that a complex trait (such as being free living vs. parasitic) cannot re-evolve again in the same form. Here, we present conclusive evidence that house dust mites, a group of medically important free-living organisms, evolved from permanent parasites of warm-blooded vertebrates. A robust, multigene topology (315 taxa, 8942 nt), ancestral character state reconstruction, and a test for irreversible evolution (Dollo?s law) demonstrate that house dust mites have abandoned a parasitic lifestyle, secondarily becoming free living, and then speciated in several habitats. Hence, as exemplified by this model system, highly specialized permanent parasites may drastically de-specialize to the extent of becoming free living and, thus escape from dead-end evolution. Our phylogenetic and historical ecological framework explains the limited cross-reactivity between allergens from the house dust mites and ?storage? mites and the ability of the dust mites to inhibit host immune responses. It also provides insights into how ancestral features related to parasitism (frequent ancestral shifts to unrelated hosts, tolerance to lower humidity, and pre-existing enzymes targeting skin and keratinous materials) played a major role in reversal to the free-living state. We propose that parasitic ancestors of pyroglyphids shifted to nests of vertebrates. Later the nest-inhabiting pyroglyphids expanded into human dwellings to become a major source of allergens.}
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 20190
  AU  - Klimov,Pavel B
  AU  - OConnor,Barry M 
  T1  - Is Permanent Parasitism Reversible??Critical Evidence from Early Evolution of House Dust Mites.
  PY  - 2011
  KW  - Ancestral ecology; Dollo?s law; evolutionary ?dead end?; house dust mites; permanent parasitism; Pyroglyphidae.
  UR  - http://dx.doi.org/10.1093/sysbio/syt008
  N2  - Long-term specialization may limit the ability of a species to respond to new environmental conditions and lead to a higher likelihood of extinction. For permanent parasites and other symbionts, the most intriguing question is whether these organisms can return to a free-living lifestyle and, thus, escape an evolutionary ?dead end.? This question is directly related to Dollo?s law, which stipulates that a complex trait (such as being free living vs. parasitic) cannot re-evolve again in the same form. Here, we present conclusive evidence that house dust mites, a group of medically important free-living organisms, evolved from permanent parasites of warm-blooded vertebrates. A robust, multigene topology (315 taxa, 8942 nt), ancestral character state reconstruction, and a test for irreversible evolution (Dollo?s law) demonstrate that house dust mites have abandoned a parasitic lifestyle, secondarily becoming free living, and then speciated in several habitats. Hence, as exemplified by this model system, highly specialized permanent parasites may drastically de-specialize to the extent of becoming free living and, thus escape from dead-end evolution. Our phylogenetic and historical ecological framework explains the limited cross-reactivity between allergens from the house dust mites and ?storage? mites and the ability of the dust mites to inhibit host immune responses. It also provides insights into how ancestral features related to parasitism (frequent ancestral shifts to unrelated hosts, tolerance to lower humidity, and pre-existing enzymes targeting skin and keratinous materials) played a major role in reversal to the free-living state. We propose that parasitic ancestors of pyroglyphids shifted to nests of vertebrates. Later the nest-inhabiting pyroglyphids expanded into human dwellings to become a major source of allergens.
  L3  - 10.1093/sysbio/syt008
  JF  - Systematic Biology
  VL  - 62
  IS  - 3
  SP  - 411
  EP  - 423
  ER  -