@ARTICLE{TreeBASE2Ref27541,
author = {Thomas Dunwell and Jordi Paps and Peter Holland},
title = {Novel and divergent genes in the evolution of placental mammals},
year = {2017},
keywords = {New genes; molecular evolution; MCL clustering; Eutheria; Placentalia},
doi = {},
url = {http://},
pmid = {},
journal = {Proceedings of the Royal Society B},
volume = {},
number = {},
pages = {},
abstract = {Analysis of genome sequences within a phylogenetic context can give insight into the mode and tempo of gene and protein evolution, including inference of gene ages. This can reveal whether new genes arose on particular evolutionary lineages and were recruited for new functional roles. Here, we apply MCL clustering with all-vs-all reciprocal BLASTP to identify and phylogenetically date ?Homology Groups? amongst vertebrate proteins. Homology Groups include new genes and highly divergent duplicate genes. Focussing on the origin of the placental mammals within the Eutheria, we identify 357 novel Homology Groups that arose on the stem lineage of Placentalia, 87 of which are deduced to play core roles in mammalian biology as judged by extensive retention in evolution. We find the human homologues of novel eutherian genes are enriched for expression in preimplantation embryo, brain, and testes, and enriched for functions in keratinization, reproductive development, and the immune system.}
}
Citation for Study 21443
Citation title:
"Novel and divergent genes in the evolution of placental mammals".
Study name:
"Novel and divergent genes in the evolution of placental mammals".
This study is part of submission 21443
(Status: Published).
Citation
Dunwell T., Paps J., & Holland P. 2017. Novel and divergent genes in the evolution of placental mammals. Proceedings of the Royal Society B, .
Authors
-
Dunwell T.
(submitter)
-
Paps J.
-
Holland P.
Abstract
Analysis of genome sequences within a phylogenetic context can give insight into the mode and tempo of gene and protein evolution, including inference of gene ages. This can reveal whether new genes arose on particular evolutionary lineages and were recruited for new functional roles. Here, we apply MCL clustering with all-vs-all reciprocal BLASTP to identify and phylogenetically date ?Homology Groups? amongst vertebrate proteins. Homology Groups include new genes and highly divergent duplicate genes. Focussing on the origin of the placental mammals within the Eutheria, we identify 357 novel Homology Groups that arose on the stem lineage of Placentalia, 87 of which are deduced to play core roles in mammalian biology as judged by extensive retention in evolution. We find the human homologues of novel eutherian genes are enriched for expression in preimplantation embryo, brain, and testes, and enriched for functions in keratinization, reproductive development, and the immune system.
Keywords
New genes; molecular evolution; MCL clustering; Eutheria; Placentalia
External links
About this resource
- Canonical resource URI:
http://purl.org/phylo/treebase/phylows/study/TB2:S21443
- Other versions:
Nexus
NeXML
- Show BibTeX reference
@ARTICLE{TreeBASE2Ref27541,
author = {Thomas Dunwell and Jordi Paps and Peter Holland},
title = {Novel and divergent genes in the evolution of placental mammals},
year = {2017},
keywords = {New genes; molecular evolution; MCL clustering; Eutheria; Placentalia},
doi = {},
url = {http://},
pmid = {},
journal = {Proceedings of the Royal Society B},
volume = {},
number = {},
pages = {},
abstract = {Analysis of genome sequences within a phylogenetic context can give insight into the mode and tempo of gene and protein evolution, including inference of gene ages. This can reveal whether new genes arose on particular evolutionary lineages and were recruited for new functional roles. Here, we apply MCL clustering with all-vs-all reciprocal BLASTP to identify and phylogenetically date ?Homology Groups? amongst vertebrate proteins. Homology Groups include new genes and highly divergent duplicate genes. Focussing on the origin of the placental mammals within the Eutheria, we identify 357 novel Homology Groups that arose on the stem lineage of Placentalia, 87 of which are deduced to play core roles in mammalian biology as judged by extensive retention in evolution. We find the human homologues of novel eutherian genes are enriched for expression in preimplantation embryo, brain, and testes, and enriched for functions in keratinization, reproductive development, and the immune system.}
}
- Show RIS reference
TY - JOUR
ID - 27541
AU - Dunwell,Thomas
AU - Paps,Jordi
AU - Holland,Peter
T1 - Novel and divergent genes in the evolution of placental mammals
PY - 2017
KW - New genes; molecular evolution; MCL clustering; Eutheria; Placentalia
UR - http://dx.doi.org/
N2 - Analysis of genome sequences within a phylogenetic context can give insight into the mode and tempo of gene and protein evolution, including inference of gene ages. This can reveal whether new genes arose on particular evolutionary lineages and were recruited for new functional roles. Here, we apply MCL clustering with all-vs-all reciprocal BLASTP to identify and phylogenetically date ?Homology Groups? amongst vertebrate proteins. Homology Groups include new genes and highly divergent duplicate genes. Focussing on the origin of the placental mammals within the Eutheria, we identify 357 novel Homology Groups that arose on the stem lineage of Placentalia, 87 of which are deduced to play core roles in mammalian biology as judged by extensive retention in evolution. We find the human homologues of novel eutherian genes are enriched for expression in preimplantation embryo, brain, and testes, and enriched for functions in keratinization, reproductive development, and the immune system.
L3 -
JF - Proceedings of the Royal Society B
VL -
IS -
ER -
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