@ARTICLE{TreeBASE2Ref26123,
author = {GOVINDAN KRISHNAMOORTHY and SUGANYA KANNAN and PRABHA PALANICHAMY and MURUGAN MARUDHAMUTHU},
title = {Evaluation of Antioxidant and Anticancer efficacy of Secondary Metabolites from Terrestrial Fungi},
year = {2016},
keywords = {soil fungi, secondary metabolites, phenols, flavonoids, antioxidant assay, MTT assay},
doi = {},
url = {http://},
pmid = {},
journal = {Fungal Biology},
volume = {},
number = {},
pages = {},
abstract = {Oxidative stress which results from the imbalance between pro-oxidant and the antioxidant concentration in the body, have been implicated as mediators of many diseases, including cancer, atherosclerosis, and cardiovascular diseases. Free radicals carry an unpaired electron and is extremely reactive and capable of engaging a rapid chain reaction that destabilizes other molecules. Hence, natural antioxidants have gained momentum among consumers and researchers because, its frequent intake reduces the cause of damage to the organs by free radicals. Cancer is currently accountable for 25% of all deaths in the developed world. In this study, a total of 55 fungal strains were isolated from terrestrial soil samples. Chosen fungal strains were selected for the extraction of secondary metabolite and phytochemical analysis. The antioxidant and anticancer potentials of three fungal strains DMTMGK004, DMTMGK008 and DMTMGK010 were analysed. Further analysis were made on the partial ITS region of the strains and phylogenetic trees were constructed. The findings of the study showed that ethyl acetate extracts of Aspergillus terreus strains DMTMGK004, DMTMGK008 and Talaromyces marneffei DMTMGK010 have demonstrated anti-proliferative action against AGS gastric cancer cells.}
}
Citation for Study 19596
Citation title:
"Evaluation of Antioxidant and Anticancer efficacy of Secondary Metabolites from Terrestrial Fungi".
Study name:
"Evaluation of Antioxidant and Anticancer efficacy of Secondary Metabolites from Terrestrial Fungi".
This study is part of submission 19596
(Status: Published).
Citation
Krishnamoorthy G., Kannan S., Palanichamy P., & Marudhamuthu M. 2016. Evaluation of Antioxidant and Anticancer efficacy of Secondary Metabolites from Terrestrial Fungi. Fungal Biology, .
Authors
-
Krishnamoorthy G.
(submitter)
9944970182
-
Kannan S.
-
Palanichamy P.
-
Marudhamuthu M.
Abstract
Oxidative stress which results from the imbalance between pro-oxidant and the antioxidant concentration in the body, have been implicated as mediators of many diseases, including cancer, atherosclerosis, and cardiovascular diseases. Free radicals carry an unpaired electron and is extremely reactive and capable of engaging a rapid chain reaction that destabilizes other molecules. Hence, natural antioxidants have gained momentum among consumers and researchers because, its frequent intake reduces the cause of damage to the organs by free radicals. Cancer is currently accountable for 25% of all deaths in the developed world. In this study, a total of 55 fungal strains were isolated from terrestrial soil samples. Chosen fungal strains were selected for the extraction of secondary metabolite and phytochemical analysis. The antioxidant and anticancer potentials of three fungal strains DMTMGK004, DMTMGK008 and DMTMGK010 were analysed. Further analysis were made on the partial ITS region of the strains and phylogenetic trees were constructed. The findings of the study showed that ethyl acetate extracts of Aspergillus terreus strains DMTMGK004, DMTMGK008 and Talaromyces marneffei DMTMGK010 have demonstrated anti-proliferative action against AGS gastric cancer cells.
Keywords
soil fungi, secondary metabolites, phenols, flavonoids, antioxidant assay, MTT assay
External links
About this resource
- Canonical resource URI:
http://purl.org/phylo/treebase/phylows/study/TB2:S19596
- Other versions:
Nexus
NeXML
- Show BibTeX reference
@ARTICLE{TreeBASE2Ref26123,
author = {GOVINDAN KRISHNAMOORTHY and SUGANYA KANNAN and PRABHA PALANICHAMY and MURUGAN MARUDHAMUTHU},
title = {Evaluation of Antioxidant and Anticancer efficacy of Secondary Metabolites from Terrestrial Fungi},
year = {2016},
keywords = {soil fungi, secondary metabolites, phenols, flavonoids, antioxidant assay, MTT assay},
doi = {},
url = {http://},
pmid = {},
journal = {Fungal Biology},
volume = {},
number = {},
pages = {},
abstract = {Oxidative stress which results from the imbalance between pro-oxidant and the antioxidant concentration in the body, have been implicated as mediators of many diseases, including cancer, atherosclerosis, and cardiovascular diseases. Free radicals carry an unpaired electron and is extremely reactive and capable of engaging a rapid chain reaction that destabilizes other molecules. Hence, natural antioxidants have gained momentum among consumers and researchers because, its frequent intake reduces the cause of damage to the organs by free radicals. Cancer is currently accountable for 25% of all deaths in the developed world. In this study, a total of 55 fungal strains were isolated from terrestrial soil samples. Chosen fungal strains were selected for the extraction of secondary metabolite and phytochemical analysis. The antioxidant and anticancer potentials of three fungal strains DMTMGK004, DMTMGK008 and DMTMGK010 were analysed. Further analysis were made on the partial ITS region of the strains and phylogenetic trees were constructed. The findings of the study showed that ethyl acetate extracts of Aspergillus terreus strains DMTMGK004, DMTMGK008 and Talaromyces marneffei DMTMGK010 have demonstrated anti-proliferative action against AGS gastric cancer cells.}
}
- Show RIS reference
TY - JOUR
ID - 26123
AU - KRISHNAMOORTHY,GOVINDAN
AU - KANNAN,SUGANYA
AU - PALANICHAMY,PRABHA
AU - MARUDHAMUTHU,MURUGAN
T1 - Evaluation of Antioxidant and Anticancer efficacy of Secondary Metabolites from Terrestrial Fungi
PY - 2016
KW - soil fungi
KW - secondary metabolites
KW - phenols
KW - flavonoids
KW - antioxidant assay
KW - MTT assay
UR - http://dx.doi.org/
N2 - Oxidative stress which results from the imbalance between pro-oxidant and the antioxidant concentration in the body, have been implicated as mediators of many diseases, including cancer, atherosclerosis, and cardiovascular diseases. Free radicals carry an unpaired electron and is extremely reactive and capable of engaging a rapid chain reaction that destabilizes other molecules. Hence, natural antioxidants have gained momentum among consumers and researchers because, its frequent intake reduces the cause of damage to the organs by free radicals. Cancer is currently accountable for 25% of all deaths in the developed world. In this study, a total of 55 fungal strains were isolated from terrestrial soil samples. Chosen fungal strains were selected for the extraction of secondary metabolite and phytochemical analysis. The antioxidant and anticancer potentials of three fungal strains DMTMGK004, DMTMGK008 and DMTMGK010 were analysed. Further analysis were made on the partial ITS region of the strains and phylogenetic trees were constructed. The findings of the study showed that ethyl acetate extracts of Aspergillus terreus strains DMTMGK004, DMTMGK008 and Talaromyces marneffei DMTMGK010 have demonstrated anti-proliferative action against AGS gastric cancer cells.
L3 -
JF - Fungal Biology
VL -
IS -
ER -