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Citation for Study 19293

Citation title: "Genome-wide survey of gut fungi (Harpellales) reveals the first horizontally transferred ubiquitin gene from a mosquito host".

Study name: "Genome-wide survey of gut fungi (Harpellales) reveals the first horizontally transferred ubiquitin gene from a mosquito host".

This study is part of submission 19293 (Status: Published).

Citation

Wang Y., White M.M., Kvist S., & Moncalvo J. 2016. Genome-wide survey of gut fungi (Harpellales) reveals the first horizontally transferred ubiquitin gene from a mosquito host. Molecular Biology and Evolution, 33(10): 2544?2554.

Authors

• Wang Y.
• White M.M.
• Kvist S. 4165868063
• Moncalvo J.

Abstract

Harpellales, an early-diverging fungal lineage, is associated with the digestive tracts of aquatic arthropod hosts. Concurrent with the production and annotation of the first four Harpellales genomes, we discovered that Zancudomyces culisetae, one of the most widely distributed Harpellales species, encodes an insect-like polyubiquitin chain. Ubiquitin and ubiquitin-like proteins are universally involved in protein degradation and regulation of immune response in eukaryotic organisms. Phylogenetic analyses inferred that this polyubiquitin variant has a mosquito origin. In addition, its amino acid composition, animal-like secondary structure, as well as the fungal nature of flanking genes all further support this as a horizontal gene transfer event. The single-copy polyubiquitin gene from Z. culisetae has lower GC ratio compared to homologs of insect taxa, which implies homogenization of the gene since its putatively ancient transfer. The acquired polyubiquitin gene may have served to improve important functions within Z. culisetae, by perhaps exploiting the insect hosts? ubiquitin-proteasome systems in the gut environment. Preliminary comparisons among the four Harpellales genomes highlight the reduced genome size of Z. culisetae, which corroborates its distinguishable symbiotic lifestyle. This is the first record of a horizontally transferred ubiquitin gene from disease-bearing insects to the gut-dwelling fungal endobiont and should invite further exploration in an evolutionary context.

Keywords

comparative genomics, evolution, Kickxellomycotina, pathogen, ubiquitination

External links

• DOI: 10.1093/molbev/msw126
• PMID: 5026252
• Other URL: http://mbe.oxfordjournals.org/content/33/10/2544.full.pdf+html

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S19293
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref25884,
  	 author = {Yan  Wang and Merlin M. White and Sebastian  Kvist and Jean-Marc  Moncalvo},
  	 title = {Genome-wide survey of gut fungi (Harpellales) reveals the first horizontally transferred ubiquitin gene from a mosquito host},
  	 year = {2016},
  	 keywords = {comparative genomics, evolution, Kickxellomycotina, pathogen, ubiquitination},
  	 doi = {10.1093/molbev/msw126},
  	 url = {http://mbe.oxfordjournals.org/content/33/10/2544.full.pdf+html},
  	 pmid = {5026252},
  	 journal = {Molecular Biology and Evolution},
  	 volume = {33},
  	 number = {10},
  	 pages = {2544?2554},
  	 abstract = {Harpellales, an early-diverging fungal lineage, is associated with the digestive tracts of aquatic arthropod hosts. Concurrent with the production and annotation of the first four Harpellales genomes, we discovered that Zancudomyces culisetae, one of the most widely distributed Harpellales species, encodes an insect-like polyubiquitin chain. Ubiquitin and ubiquitin-like proteins are universally involved in protein degradation and regulation of immune response in eukaryotic organisms. Phylogenetic analyses inferred that this polyubiquitin variant has a mosquito origin. In addition, its amino acid composition, animal-like secondary structure, as well as the fungal nature of flanking genes all further support this as a horizontal gene transfer event. The single-copy polyubiquitin gene from Z. culisetae has lower GC ratio compared to homologs of insect taxa, which implies homogenization of the gene since its putatively ancient transfer. The acquired polyubiquitin gene may have served to improve important functions within Z. culisetae, by perhaps exploiting the insect hosts? ubiquitin-proteasome systems in the gut environment. Preliminary comparisons among the four Harpellales genomes highlight the reduced genome size of Z. culisetae, which corroborates its distinguishable symbiotic lifestyle. This is the first record of a horizontally transferred ubiquitin gene from disease-bearing insects to the gut-dwelling fungal endobiont and should invite further exploration in an evolutionary context.}
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 25884
  AU  - Wang,Yan 
  AU  - White,Merlin M.
  AU  - Kvist,Sebastian 
  AU  - Moncalvo,Jean-Marc 
  T1  - Genome-wide survey of gut fungi (Harpellales) reveals the first horizontally transferred ubiquitin gene from a mosquito host
  PY  - 2016
  KW  - comparative genomics
  KW  - evolution
  KW  - Kickxellomycotina
  KW  - pathogen
  KW  - ubiquitination
  UR  - http://mbe.oxfordjournals.org/content/33/10/2544.full.pdf+html
  N2  - Harpellales, an early-diverging fungal lineage, is associated with the digestive tracts of aquatic arthropod hosts. Concurrent with the production and annotation of the first four Harpellales genomes, we discovered that Zancudomyces culisetae, one of the most widely distributed Harpellales species, encodes an insect-like polyubiquitin chain. Ubiquitin and ubiquitin-like proteins are universally involved in protein degradation and regulation of immune response in eukaryotic organisms. Phylogenetic analyses inferred that this polyubiquitin variant has a mosquito origin. In addition, its amino acid composition, animal-like secondary structure, as well as the fungal nature of flanking genes all further support this as a horizontal gene transfer event. The single-copy polyubiquitin gene from Z. culisetae has lower GC ratio compared to homologs of insect taxa, which implies homogenization of the gene since its putatively ancient transfer. The acquired polyubiquitin gene may have served to improve important functions within Z. culisetae, by perhaps exploiting the insect hosts? ubiquitin-proteasome systems in the gut environment. Preliminary comparisons among the four Harpellales genomes highlight the reduced genome size of Z. culisetae, which corroborates its distinguishable symbiotic lifestyle. This is the first record of a horizontally transferred ubiquitin gene from disease-bearing insects to the gut-dwelling fungal endobiont and should invite further exploration in an evolutionary context.
  L3  - 10.1093/molbev/msw126
  JF  - Molecular Biology and Evolution
  VL  - 33
  IS  - 10
  ER  -