@ARTICLE{TreeBASE2Ref22599,
author = {lihuan Cao},
title = {Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages},
year = {2014},
keywords = { Cell cycle; Evolution; Metazoan emergence; CDK; Cyclin},
doi = {},
url = {http://},
pmid = {},
journal = {BMC Evolutionary Biology},
volume = {14},
number = {},
pages = {10},
abstract = {Background
The molecular history of animal evolution from single-celled ancestors remains a major question in biology, and little is known regarding the evolution of cell cycle regulation during animal emergence. In this study, we conducted a comprehensive evolutionary analysis of CDK and cyclin proteins in metazoans and their unicellular relatives.
Results
Our analysis divided the CDK family into eight subfamilies. Seven subfamilies (CDK1/2/3, CDK5, CDK7, CDK 20, CDK8/19, CDK9, and CDK10/11) are conserved in metazoans and fungi, with the remaining subfamily, CDK4/6, found only in eumetazoans. With respect to cyclins, cyclin C, H, L, Y subfamilies, and cyclin K and T as a whole subfamily, are generally conserved in animal, fungi, and amoeba Dictyostelium discoideum.. In contrast, cyclin subfamilies B, A, E, and D, which are cell cycle-related, have distinct evolutionary histories. The cyclin B subfamily is generally conserved in D. discoideum, fungi, and animals, whereas cyclin A and E subfamilies are both present in animals and their unicellular relatives such as choanoflagellate Monosiga brevicollis and filasterean Capsaspora owczarzaki, but are absent in fungi and D. discoideum. Although absent in fungi and D. discoideum, cyclin D subfamily orthologs can be found in the early-emerging, non-opisthokont apusozoan Thecamonas trahens. Within opisthokonta, the cyclin D subfamily is conserved only in eumetazoans, and is absent in fungi, choanoflagellates, and the basal metazoan Amphimedon queenslandica.
Conclusions
Our data indicate that the CDK4/6 subfamily and eumetazoans emerged simultaneously, with the evolutionary conservation of the cyclin D subfamily also tightly linked with eumetazoan appearance. Establishment of the CDK4/6-cyclin D complex may have been the key step in the evolution of cell cycle control during eumetazoan emergence.
}
}
Taxa for tree 70726 of Study 14979
Citation title:
"Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages".
Study name:
"Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages".
This study is part of submission 14979
(Status: Published).
Taxa
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ID |
Taxon Label |
NCBI taxid |
uBIO namebankID |
1411056 |
Amphimedon queenslandica GI 340369567 |
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1411106 |
Amphimedon queenslandica GI 340370065 |
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1411024 |
Amphimedon queenslandica GI 340373128 |
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1411050 |
Amphimedon queenslandica GI 340373665 |
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1411071 |
Amphimedon queenslandica GI 340374274 |
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1411026 |
Amphimedon queenslandica GI 340376468 |
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1411100 |
Amphimedon queenslandica GI 340376480 |
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1411041 |
Amphimedon queenslandica GI 340377763 |
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1411080 |
Amphimedon queenslandica GI 340378990 |
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1411078 |
Amphimedon queenslandica GI 340379451 |
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1411070 |
Amphimedon queenslandica GI 340379787 |
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1411051 |
Amphimedon queenslandica GI 340380250 |
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1411087 |
Amphimedon queenslandica GI 340380414 |
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|
1411085 |
Homo sapiens CABLES1 |
9606
|
2481730
|
1411054 |
Homo sapiens CABLES2 |
9606
|
2481730
|
1411049 |
Homo sapiens CyclinA1 |
9606
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2481730
|
1411066 |
Homo sapiens CyclinA2 |
9606
|
2481730
|
1411063 |
Homo sapiens CyclinB1 |
9606
|
2481730
|
1411108 |
Homo sapiens CyclinB2 |
9606
|
2481730
|
1411110 |
Homo sapiens CyclinB3 |
9606
|
2481730
|
1411028 |
Homo sapiens CyclinC |
9606
|
2481730
|
1411095 |
Homo sapiens CyclinD1 |
9606
|
2481730
|
1411062 |
Homo sapiens CyclinD2 |
9606
|
2481730
|
1411042 |
Homo sapiens CyclinD3 |
9606
|
2481730
|
1411105 |
Homo sapiens CyclinE1 |
9606
|
2481730
|
1411075 |
Homo sapiens CyclinE2 |
9606
|
2481730
|
1411102 |
Homo sapiens CyclinF |
9606
|
2481730
|
1411083 |
Homo sapiens CyclinG1 |
9606
|
2481730
|
1411076 |
Homo sapiens CyclinG2 |
9606
|
2481730
|
1411111 |
Homo sapiens CyclinH |
9606
|
2481730
|
1411052 |
Homo sapiens CyclinI |
9606
|
2481730
|
1411038 |
Homo sapiens CyclinI2 |
9606
|
2481730
|
1411025 |
Homo sapiens CyclinJ |
9606
|
2481730
|
1411027 |
Homo sapiens CyclinJL |
9606
|
2481730
|
1411032 |
Homo sapiens CyclinK |
9606
|
2481730
|
1411084 |
Homo sapiens CyclinL1 |
9606
|
2481730
|
1411030 |
Homo sapiens CyclinL2 |
9606
|
2481730
|
1411088 |
Homo sapiens CyclinO |
9606
|
2481730
|
1411067 |
Homo sapiens CyclinT1 |
9606
|
2481730
|
1411109 |
Homo sapiens CyclinT2 |
9606
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2481730
|
1411053 |
Homo sapiens CyclinY |
9606
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2481730
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1411058 |
Homo sapiens CyclinYL |
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1411046 |
Homo sapiens Fam58A |
9606
|
2481730
|
1411069 |
Homo sapiens Fam58B |
9606
|
2481730
|
1411037 |
Monosiga brevicollis GI 167517989 |
81824
|
3398671
|
1411103 |
Monosiga brevicollis GI 167522783 |
81824
|
3398671
|
1411039 |
Monosiga brevicollis GI 167523717 |
81824
|
3398671
|
1411089 |
Monosiga brevicollis GI 167524110 |
81824
|
3398671
|
1411101 |
Monosiga brevicollis GI 167526102 |
81824
|
3398671
|
1411035 |
Monosiga brevicollis GI 167526156 |
81824
|
3398671
|
1411068 |
Nematostella vectensis GI 156350442 |
45351
|
3866609
|
1411045 |
Nematostella vectensis GI 156359300 |
45351
|
3866609
|
1411040 |
Nematostella vectensis GI 156359932 |
45351
|
3866609
|
1411094 |
Nematostella vectensis GI 156363375 |
45351
|
3866609
|
1411065 |
Nematostella vectensis GI 156364707 |
45351
|
3866609
|
1411079 |
Nematostella vectensis GI 156365799 |
45351
|
3866609
|
1411093 |
Nematostella vectensis GI 156365937 |
45351
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3866609
|
1411099 |
Nematostella vectensis GI 156375154 |
45351
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3866609
|
1411082 |
Nematostella vectensis GI 156380901 |
45351
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3866609
|
1411034 |
Nematostella vectensis GI 156381346 |
45351
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3866609
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1411064 |
Nematostella vectensis GI 156389378 |
45351
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3866609
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1411077 |
Nematostella vectensis GI 156397054 |
45351
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3866609
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1411061 |
Nematostella vectensis GI 156405242 |
45351
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3866609
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1411033 |
Nematostella vectensis GI 156406586 |
45351
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3866609
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1411072 |
Nematostella vectensis GI 156407073 |
45351
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3866609
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1411092 |
Nematostella vectensis GI 156408249 |
45351
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3866609
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1411059 |
Salpingoeca rosetta GI 326426811 |
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1411031 |
Salpingoeca rosetta GI 326428978 |
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1411048 |
Salpingoeca rosetta GI 326429298 |
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1411098 |
Salpingoeca rosetta GI 326435281 |
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1411086 |
Salpingoeca rosetta GI 326437558 |
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1411074 |
Salpingoeca rosetta GI 326437566 |
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1411044 |
Salpingoeca rosetta GI 326437823 |
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1411096 |
Salpingoeca rosetta GI 326437989 |
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1411104 |
Thecamonas adhaerens GI 195998946 |
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1411043 |
Thecamonas adhaerens GI 195999522 |
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1411091 |
Thecamonas adhaerens GI 196000815 |
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1411036 |
Thecamonas adhaerens GI 196001479 |
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1411047 |
Thecamonas adhaerens GI 196002535 |
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1411097 |
Thecamonas adhaerens GI 196003236 |
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1411107 |
Thecamonas adhaerens GI 196003740 |
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1411060 |
Thecamonas adhaerens GI 196005765 |
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1411055 |
Thecamonas adhaerens GI 196007260 |
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1411029 |
Thecamonas adhaerens GI 196007480 |
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1411057 |
Thecamonas adhaerens GI 196011367 |
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1411090 |
Thecamonas adhaerens GI 196012973 |
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1411081 |
Thecamonas adhaerens GI 196013209 |
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1411073 |
Thecamonas adhaerens GI 196013340 |
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