@ARTICLE{TreeBASE2Ref27820, author = {Yoshihiro Takaki and Takuro Nunoura}, title = {A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile}, year = {2017}, keywords = {chemolithoautotrophic}, doi = {10.1126/science.aao3407}, url = {http://}, pmid = {}, journal = {Science}, volume = {359}, number = {}, pages = {559}, abstract = {Inorganic carbon fixation is essential to sustain life on Earth, and the reductive tricarboxylic acid (rTCA) cycle is one of the most ancient carbon fixation metabolisms. A combination of genomic, enzymatic and metabolomic analyses of a deeply-branching chemolithotrophic Thermosulfidibacter takaii ABI70S6T revealed an unprecedented reversible TCA cycle whose direction was controlled by the available carbon source(s). Under a chemolithoautotrophic condition, a rTCA cycle occurred with the reverse reaction of citrate synthase (CS) but not with the ATP-dependent citrate cleavage reactions that had been regarded essential for the conventional rTCA cycle. Phylometabolic evaluation suggests that the TCA cycle with reversible CS may represent an ancestral mode of the (r)TCA cycle and raises the possibilities of a chemolithomixotrophic origin of life. } }

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