@ARTICLE{TreeBASE2Ref28535,
author = {Rahul Salunke and Tobias Mourier and Manidipa Banerjee and Arnab Pain and Dhanasekaran Shanmuga},
title = {Highly diverged novel subunit composition of apicomplexan F-type ATP synthase identified from Toxoplasma gondii},
year = {2018},
keywords = {},
doi = {},
url = {http://},
pmid = {},
journal = {PLoS Biology},
volume = {},
number = {},
pages = {},
abstract = {The mitochondrial F-type ATP synthase, a multi-subunit nanomotor, is critical for maintaining cellular ATP levels. In Toxoplasma gondii and other apicomplexan parasites, many subunit components, necessary for proper assembly and functioning of this enzyme, appear to be missing. Here, we report the identification of 20 novel subunits of T. gondii F-type ATP synthase from mass spectrometry analysis of partially purified monomer (~600 kDa) and dimer (>1 MDa) forms of the enzyme. Despite extreme sequence diversification, key FO subunits, a, b and d, can be identified from conserved structural features. Orthologs for many of these proteins are restricted to apicomplexan, chromerid and dinoflagellate species. Interestingly, their absence in ciliates indicates a major diversion, with respect to subunit composition of this enzyme, within the alveolate clade. Discovery of these highly diversified novel components of the apicomplexan F-type ATP synthase complex will facilitate the development of novel anti-parasitic agents. Structural and functional characterization of this unusual enzyme complex will advance our fundamental of energy metabolism in apicomplexan species}
}
Taxa for tree 112242 of Study 22877
Citation title:
"Highly diverged novel subunit composition of apicomplexan F-type ATP synthase identified from Toxoplasma gondii".
Study name:
"Highly diverged novel subunit composition of apicomplexan F-type ATP synthase identified from Toxoplasma gondii".
This study is part of submission 22877
(Status: Published).
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