@ARTICLE{TreeBASE2Ref20057,
author = {Daniel Paul Lawrence and Scott Kroken and Barry M. Pryor and A. Elizabeth Arnold},
title = {Interkingdom Gene Transfer of a Hybrid NPS/PKS from Bacteria to Filamentous Ascomycota},
year = {2011},
keywords = {Horizontal gene transfer, NRPS, PKS, secondary metabolites},
doi = {},
url = {http://},
pmid = {},
journal = {PLoS ONE},
volume = {},
number = {},
pages = {},
abstract = {Nonribosomal peptides (NRPs) and polyketides (PKs) are ecologically important secondary metabolites produced by bacteria and fungi using multidomain enzymes called nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs), respectively. Previous phylogenetic analyses of fungal NPSs and PKSs have suggested that some a few of these genes were acquired by fungi via horizontal gene transfer (HGT) from bacteria, including a hybrid NRPS/PKS found in Cochliobolus heterostrophus (Dothideomycetes, Ascomycota). Here, we identify this hybrid gene in fungi representing two additional classes of Ascomycota (Aspergillus spp., and Microsporum canis, Arthroderma spp., and Trichophyton spp., Eurotiomycetes; Chaetomium spp. and Metarhizium spp., Sordariomycetes) and use phylogenetic analyses of the most highly conserved domains from NRPSs (adenylation (A) domain) and PKSs (ketoacyl synthase (KS) domain) to examine the hypothesis that the hybrid NRPS7/PKS24 was acquired by fungi from bacteria via HGT relatively early in the evolution of the Pezizomycotina. Our results reveal the distinctiveness of the A domain and KS domain in the hybrid gene relative to known NRPSs and PKSs in fungi, provide strong evidence for HGT of the hybrid gene from a putative bacterial donor in the Burkholderiales, and suggest a HGT event early in the evolution of the filamentous Ascomycota.}
}
Go to search
Citation
Taxa
Matrices
Trees
Analyses
Citation title: "Interkingdom Gene Transfer of a Hybrid NPS/PKS from Bacteria to Filamentous Ascomycota".
