@ARTICLE{TreeBASE2Ref25351, author = {Abdullah Mohammed Al-Hatmi}, title = {Fusarium ramigenum as a novel human opportunist in a patient with common variable immunodeficiency and cellular immune defects }, year = {2015}, keywords = {Key words: Fusarium ramigenum infection, immune deficiency, gamma-interferon, IL-17 deficiency}, doi = {}, url = {http://}, pmid = {}, journal = {BMC Infectious Diseases}, volume = {}, number = {}, pages = {}, abstract = {Background: Fusarium species are ubiquitous environmental fungi and can provoke serious invasive infections in immunocompromised hosts. Among Fusarium species, Fusarium ramigenum, belonging to fujikuroi complex, was never identified as a human pathogen. Here we describe the first case of invasive fusariosis caused by Fusarium ramigenum in human and also describe the immunological deficiencies most likely contributing to the invasiveness. Case presentation: A 32-year-old Caucasian male with an apparent insignificant medical history of mild respiratory illnesses during the previous two years, developed invasive pulmonary fusariosis. Detailed immunological assessment revealed the presence of common variable immunodeficiency, complicated by a severe impairment of the capacity of T-cells to produce both gamma-interferon and interleukin-17. In-depth microbiological assessment identified the novel human opportunistic pathogen Fusarium ramigenum as cause of the infection. Conclusion: This report demonstrated that an opportunistic invasive fungal infection usually indicates an underlying cellular immune impairment of the host. The unexpected invasive infection with Fusarium ramigenum in this case unmasked complex combined humoral and cellular immunological deficiencies. } }

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