@ARTICLE{TreeBASE2Ref29780, author = {Luis Emilio Cartuche and Ines Sifaoui and Dar?o Javier Cruz and Mar?a Reyes-Batlle and Atteneri L?pez-Arencibia and Jos? Javier Fern?ndez and Ana D?az-Marrero and Jos? Pi?ero and Jacob Lorenzo-Morales}, title = {Staurosporine from Streptomyces sanyensis activates Programmed Cell Death in Acanthamoeba via the mitochondrial pathway}, year = {2019}, keywords = {n/n}, doi = {}, url = {http://}, pmid = {}, journal = {Scientific Reports}, volume = {}, number = {}, pages = {}, abstract = {Recently, the search for novel therapeutic agents against Acanthamoeba species has been focused in the evaluation of natural resources. Among them, marine microorganisms have risen as a source of bioactive compounds with the advantage to be able to obtain unlimited and constant amounts of the compounds in contrast to other natural sources such as plants. Furthermore, marine actinomycetes have recently been reported as highly rich in bioactive agents including salinosporamides, xiamycines, indolocarbazoles, naphtyridines, phenols, dilactones such as antimycines, macrolides among others. In this study, Staurosporine (STS) was isolated from a strain of Streptomyces sanyensis and tested against both stages of Acanthamoeba sp. with the aim to develop STS therapeutic potential against this protozoan. Furthermore, and after establishing low toxicity, the mechanism of action of STS was evaluated. The obtained results concluded that STS is active against both stages of Acanthamoeba life cycle and also activates killing of the parasite by activation of Programmed Cell Death via the mitochondrial pathway.} }

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