@ARTICLE{TreeBASE2Ref20057,
author = {Daniel Paul Lawrence and Scott Kroken and Barry M. Pryor and A. Elizabeth Arnold},
title = {Interkingdom Gene Transfer of a Hybrid NPS/PKS from Bacteria to Filamentous Ascomycota},
year = {2011},
keywords = {Horizontal gene transfer, NRPS, PKS, secondary metabolites},
doi = {},
url = {http://},
pmid = {},
journal = {PLoS ONE},
volume = {},
number = {},
pages = {},
abstract = {Nonribosomal peptides (NRPs) and polyketides (PKs) are ecologically important secondary metabolites produced by bacteria and fungi using multidomain enzymes called nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs), respectively. Previous phylogenetic analyses of fungal NPSs and PKSs have suggested that some a few of these genes were acquired by fungi via horizontal gene transfer (HGT) from bacteria, including a hybrid NRPS/PKS found in Cochliobolus heterostrophus (Dothideomycetes, Ascomycota). Here, we identify this hybrid gene in fungi representing two additional classes of Ascomycota (Aspergillus spp., and Microsporum canis, Arthroderma spp., and Trichophyton spp., Eurotiomycetes; Chaetomium spp. and Metarhizium spp., Sordariomycetes) and use phylogenetic analyses of the most highly conserved domains from NRPSs (adenylation (A) domain) and PKSs (ketoacyl synthase (KS) domain) to examine the hypothesis that the hybrid NRPS7/PKS24 was acquired by fungi from bacteria via HGT relatively early in the evolution of the Pezizomycotina. Our results reveal the distinctiveness of the A domain and KS domain in the hybrid gene relative to known NRPSs and PKSs in fungi, provide strong evidence for HGT of the hybrid gene from a putative bacterial donor in the Burkholderiales, and suggest a HGT event early in the evolution of the filamentous Ascomycota.}
}
Citation for Study 11936
Citation title:
"Interkingdom Gene Transfer of a Hybrid NPS/PKS from Bacteria to Filamentous Ascomycota".
Study name:
"Interkingdom Gene Transfer of a Hybrid NPS/PKS from Bacteria to Filamentous Ascomycota".
This study is part of submission 11936
(Status: Published).
Citation
Lawrence D.P., Kroken S., Pryor B., & Arnold A. 2011. Interkingdom Gene Transfer of a Hybrid NPS/PKS from Bacteria to Filamentous Ascomycota. PLoS ONE, .
Authors
-
Lawrence D.P.
(submitter)
530-6752-6745
-
Kroken S.
-
Pryor B.
-
Arnold A.
Abstract
Nonribosomal peptides (NRPs) and polyketides (PKs) are ecologically important secondary metabolites produced by bacteria and fungi using multidomain enzymes called nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs), respectively. Previous phylogenetic analyses of fungal NPSs and PKSs have suggested that some a few of these genes were acquired by fungi via horizontal gene transfer (HGT) from bacteria, including a hybrid NRPS/PKS found in Cochliobolus heterostrophus (Dothideomycetes, Ascomycota). Here, we identify this hybrid gene in fungi representing two additional classes of Ascomycota (Aspergillus spp., and Microsporum canis, Arthroderma spp., and Trichophyton spp., Eurotiomycetes; Chaetomium spp. and Metarhizium spp., Sordariomycetes) and use phylogenetic analyses of the most highly conserved domains from NRPSs (adenylation (A) domain) and PKSs (ketoacyl synthase (KS) domain) to examine the hypothesis that the hybrid NRPS7/PKS24 was acquired by fungi from bacteria via HGT relatively early in the evolution of the Pezizomycotina. Our results reveal the distinctiveness of the A domain and KS domain in the hybrid gene relative to known NRPSs and PKSs in fungi, provide strong evidence for HGT of the hybrid gene from a putative bacterial donor in the Burkholderiales, and suggest a HGT event early in the evolution of the filamentous Ascomycota.
Keywords
Horizontal gene transfer, NRPS, PKS, secondary metabolites
External links
About this resource
- Canonical resource URI:
http://purl.org/phylo/treebase/phylows/study/TB2:S11936
- Other versions:
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- Show BibTeX reference
@ARTICLE{TreeBASE2Ref20057,
author = {Daniel Paul Lawrence and Scott Kroken and Barry M. Pryor and A. Elizabeth Arnold},
title = {Interkingdom Gene Transfer of a Hybrid NPS/PKS from Bacteria to Filamentous Ascomycota},
year = {2011},
keywords = {Horizontal gene transfer, NRPS, PKS, secondary metabolites},
doi = {},
url = {http://},
pmid = {},
journal = {PLoS ONE},
volume = {},
number = {},
pages = {},
abstract = {Nonribosomal peptides (NRPs) and polyketides (PKs) are ecologically important secondary metabolites produced by bacteria and fungi using multidomain enzymes called nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs), respectively. Previous phylogenetic analyses of fungal NPSs and PKSs have suggested that some a few of these genes were acquired by fungi via horizontal gene transfer (HGT) from bacteria, including a hybrid NRPS/PKS found in Cochliobolus heterostrophus (Dothideomycetes, Ascomycota). Here, we identify this hybrid gene in fungi representing two additional classes of Ascomycota (Aspergillus spp., and Microsporum canis, Arthroderma spp., and Trichophyton spp., Eurotiomycetes; Chaetomium spp. and Metarhizium spp., Sordariomycetes) and use phylogenetic analyses of the most highly conserved domains from NRPSs (adenylation (A) domain) and PKSs (ketoacyl synthase (KS) domain) to examine the hypothesis that the hybrid NRPS7/PKS24 was acquired by fungi from bacteria via HGT relatively early in the evolution of the Pezizomycotina. Our results reveal the distinctiveness of the A domain and KS domain in the hybrid gene relative to known NRPSs and PKSs in fungi, provide strong evidence for HGT of the hybrid gene from a putative bacterial donor in the Burkholderiales, and suggest a HGT event early in the evolution of the filamentous Ascomycota.}
}
- Show RIS reference
TY - JOUR
ID - 20057
AU - Lawrence,Daniel Paul
AU - Kroken,Scott
AU - Pryor,Barry M.
AU - Arnold,A. Elizabeth
T1 - Interkingdom Gene Transfer of a Hybrid NPS/PKS from Bacteria to Filamentous Ascomycota
PY - 2011
KW - Horizontal gene transfer
KW - NRPS
KW - PKS
KW - secondary metabolites
UR - http://dx.doi.org/
N2 - Nonribosomal peptides (NRPs) and polyketides (PKs) are ecologically important secondary metabolites produced by bacteria and fungi using multidomain enzymes called nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs), respectively. Previous phylogenetic analyses of fungal NPSs and PKSs have suggested that some a few of these genes were acquired by fungi via horizontal gene transfer (HGT) from bacteria, including a hybrid NRPS/PKS found in Cochliobolus heterostrophus (Dothideomycetes, Ascomycota). Here, we identify this hybrid gene in fungi representing two additional classes of Ascomycota (Aspergillus spp., and Microsporum canis, Arthroderma spp., and Trichophyton spp., Eurotiomycetes; Chaetomium spp. and Metarhizium spp., Sordariomycetes) and use phylogenetic analyses of the most highly conserved domains from NRPSs (adenylation (A) domain) and PKSs (ketoacyl synthase (KS) domain) to examine the hypothesis that the hybrid NRPS7/PKS24 was acquired by fungi from bacteria via HGT relatively early in the evolution of the Pezizomycotina. Our results reveal the distinctiveness of the A domain and KS domain in the hybrid gene relative to known NRPSs and PKSs in fungi, provide strong evidence for HGT of the hybrid gene from a putative bacterial donor in the Burkholderiales, and suggest a HGT event early in the evolution of the filamentous Ascomycota.
L3 -
JF - PLoS ONE
VL -
IS -
ER -
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