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Citation for Study 12416

Citation title: "Evolutionary Diversity of the Mitochondrial Calcium Uniporter".

Study name: "Evolutionary Diversity of the Mitochondrial Calcium Uniporter".

This study is part of submission 12416 (Status: Published).

Citation

Bick A.G., Calvo S.E., & Mootha V.K. 2012. Evolutionary Diversity of the Mitochondrial Calcium Uniporter. Science, 336(6083): 886.

Authors

• Bick A.G.
• Calvo S.E.
• Mootha V.K.

Abstract

Calcium uptake into mitochondria occurs via a recently identified uniporter, which represents a new class of ion channels. Here we characterize the phylogenomic distribution of its membrane spanning pore (MCU) and regulatory partner (MICU1). Homologs of both components tend to co-occur in all major branches of eukaryotic life but both have been lost along certain protozoan and fungal lineages. Several bacterial genomes also contain putative MCU homologs that may represent prokaryotic calcium channels. The analyses indicate that the uniporter may have been an early feature of mitochondria.

Keywords

MCU MICU1 Calcium

External links

• PMID: 22605770

About this resource

• Canonical resource URI: http://purl.org/phylo/treebase/phylows/study/TB2:S12416
• Other versions: Nexus NeXML
• Show BibTeX reference

  		@ARTICLE{TreeBASE2Ref20471,
  	 author = {Alex G Bick and Sarah E Calvo and Vamsi K Mootha},
  	 title = {Evolutionary Diversity of the Mitochondrial Calcium Uniporter},
  	 year = {2012},
  	 keywords = {MCU MICU1 Calcium},
  	 doi = {},
  	 url = {http://},
  	 pmid = {22605770},
  	 journal = {Science},
  	 volume = {336},
  	 number = {6083},
  	 pages = {886},
  	 abstract = {Calcium uptake into mitochondria occurs via a recently identified uniporter, which represents a new class of ion channels.  Here we characterize the phylogenomic distribution of its membrane spanning pore (MCU) and regulatory partner (MICU1).  Homologs of both components tend to co-occur in all major branches of eukaryotic life but both have been lost along certain protozoan and fungal lineages.  Several bacterial genomes also contain putative MCU homologs that may represent prokaryotic calcium channels.  The analyses indicate that the uniporter may have been an early feature of mitochondria.}
  }
  		

• Show RIS reference

  		TY  - JOUR
  ID  - 20471
  AU  - Bick,Alex G
  AU  - Calvo,Sarah E
  AU  - Mootha,Vamsi K
  T1  - Evolutionary Diversity of the Mitochondrial Calcium Uniporter
  PY  - 2012
  KW  - MCU MICU1 Calcium
  UR  - http://dx.doi.org/
  N2  - Calcium uptake into mitochondria occurs via a recently identified uniporter, which represents a new class of ion channels.  Here we characterize the phylogenomic distribution of its membrane spanning pore (MCU) and regulatory partner (MICU1).  Homologs of both components tend to co-occur in all major branches of eukaryotic life but both have been lost along certain protozoan and fungal lineages.  Several bacterial genomes also contain putative MCU homologs that may represent prokaryotic calcium channels.  The analyses indicate that the uniporter may have been an early feature of mitochondria.
  L3  - 
  JF  - Science
  VL  - 336
  IS  - 6083
  ER  -